51. A Comparison of Accuracy between IMMULITE2000® and GENEDIA® for Helicobacter pylori Infection
- Author
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Hyun Joo Song, Gwang Ho Baik, Seon Hee Lim, Hyun-Jin Kim, Kyung Sik Park, Sungeun Kim, Jeong Eun Shin, Suck Chei Choi, Dae Seong Myung, Nayoung Kim, and Ju Yup Lee
- Subjects
Helicobacter pylori infection ,lcsh:Internal medicine ,biology ,business.industry ,serology ,Helicobacter pylori ,biology.organism_classification ,Virology ,Serology ,03 medical and health sciences ,0302 clinical medicine ,immunoenzyme techniques ,030220 oncology & carcinogenesis ,Immunoenzyme techniques ,Medicine ,030211 gastroenterology & hepatology ,enzyme-linked immunosorbent assay ,business ,lcsh:RC31-1245 - Abstract
Background/Aims: In serological tests for Helicobacter pylori (H. pylori), an enzyme-linked immunosorbent assay (GENEDIA®) and a solid-phase, two-step chemiluminescent enzyme immunoassay (IMMULITE®), which are easy to perform, inexpensive, and widely available, are commonly used. However, local validation of the test performance of IMMULITE® is required. This study aimed to examine the performance of IMMULITE® in comparison with that of GENEDIA® in a Korean health checkup population.Materials and Methods: The sera of 300 subjects among those who underwent health checkup were analyzed using IMMULITE®, and results were compared with those of GENEDIA®. The two serological tests were compared for their ability to predict atrophic gastritis (AG) or intestinal metaplasia (IM) on endoscopy.Results: We found significant correlation (Pearson correlation coefficient=0.903, PP® and IMMULITE®. The area under the receiver operating characteristics curve (AUC) for AG using GENEDIA® and IMMULITE® were 0.590 and 0.604, respectively, and showed no statistically significant difference in predictive ability for AG (Z-statistics=-0.517, P=0.605). The AUC for IM by GENEDIA® and IMMULITE® were 0.578 and 0.593, respectively, with no statistically significant difference in predictive ability for IM between the two values (Z-statistics=-0.398, P=0.691).Conclusions: No statistically significant difference in diagnostic value for H. pylori infection was found between GENEDIA® and IMMULITE®.
- Published
- 2020