54 results on '"Hyuk Jin Yun"'
Search Results
52. Patterns of Neuropsychological Profile and Cortical Thinning in Parkinson’s Disease with Punding
- Author
-
Young H. Sohn, Han Soo Yoo, Hyuk Jin Yun, Jongmin Lee, Seok Jong Chung, Phil Hyu Lee, and Mun Kyung Sunwoo
- Subjects
Male ,medicine.medical_specialty ,Parkinson's disease ,lcsh:Medicine ,Neuropsychological Tests ,Audiology ,Executive Function ,Punding ,Humans ,Medicine ,Prospective Studies ,lcsh:Science ,Prefrontal cortex ,Psychiatry ,Aged ,Cerebral Cortex ,Multidisciplinary ,business.industry ,lcsh:R ,Neuropsychology ,Parkinson Disease ,Middle Aged ,Executive functions ,medicine.disease ,Frontal lobe ,lcsh:Q ,Female ,Stereotyped Behavior ,Cognition Disorders ,business ,Neurocognitive ,Research Article ,Follow-Up Studies ,Stroop effect - Abstract
Background Punding, one of dopamine replacement treatment related complications, refers to aimless and stereotyped behaviors. To identify possible neural correlates of punding behavior in patients with Parkinson’s disease (PD), we investigated the patterns of cognitive profiles and cortical thinning. Methods Of the 186 subjects with PD screened during the study period, we prospectively enrolled 10 PD patients with punding and 43 without punding on the basis of a structured interview. We performed comprehensive neuropsychological tests and voxel-based and regions-of-interest (ROIs)-based cortical thickness analysis between PD patients with and without punding. Results The prevalence of punding in patients with PD was 5.4%. Punding behaviors were closely related to previous occupations or hobbies and showed a temporal relationship to changes of levodopa-equivalent dose (LED). Significant predisposing factors were a long duration of PD and intake of medications of PD, high total daily LED, dyskinesia, and impulse control disorder. Punding severity was correlated with LED (p = 0.029). The neurocognitive assessment revealed that PD patients with punding showed more severe cognitive deficits in the color Stroop task than did those without punding (p = 0.022). Voxel-based analysis showed that PD-punders had significant cortical thinning in the dorsolateral prefrontal area relative to controls. Additionally, ROI-based analysis revealed that cortical thinning in PD-punders relative to PD-nonpunders was localized in the prefrontal cortices, extending into orbitofrontal area. Conclusions We demonstrated that PD patients with punding performed poorly on cognitive tasks in frontal executive functions and showed severe cortical thinning in the dorsolateral prefrontal and orbitofrontal areas. These findings suggest that prefrontal modulation may be an essential component in the development of punding behavior in patients with PD.
- Published
- 2015
53. Comparison of regional brain atrophy and cognitive impairment between pure akinesia with gait freezing and Richardson's syndrome.
- Author
-
Jin Yong Hong, Hyuk Jin Yun, Mun Kyung Sunwoo, Jee Hyun Ham, Jong-Min Lee, Sohn, Young H., Hyu Lee, Phil, Madeo, Graziella, Tan, Uner, and Martorana, Alessandro
- Subjects
CEREBRAL atrophy ,MILD cognitive impairment ,GAIT disorders in old age ,PHENOTYPES ,PSEUDOBULBAR paralysis - Abstract
Pure akinesia with gait freezing (PAGF) is considered a clinical phenotype of progressive supranuclear palsy. The brain atrophy and cognitive deficits in PAGF are expected to be less prominent than in classical Richardson's syndrome (RS), but this hypothesis has not been explored yet. We reviewed the medical records of 28 patients with probable RS, 19 with PAGF, and 29 healthy controls, and compared cortical thickness, subcortical gray matter volume, and neuropsychological performance among the three groups. Patients with PAGF had thinner cortices in frontal, inferior parietal, and temporal areas compared with controls; however, areas of cortical thinning in PAGF patients were less extensive than those in RS patients. In PAGF patients, hippocampal, and thalamic volumes were also smaller than controls, whereas subcortical gray matter volumes in PAGF and RS patients were comparable. In a comparison of neuropsychological tests, PAGF patients had better cognitive performance in executive function, visual memory, and visuospatial function than RS patients had. These results demonstrate that cognitive impairment, cortical thinning, and subcortical gray matter atrophy in PAGF patients resemble to those in RS patients, though the severity of cortical thinning and cognitive dysfunction is milder. Our results suggest that, PAGF and RS may share same pathology but that it appears to affect a smaller proportion of the cortex in PAGF. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
54. Mesenchymal stem cells can modulate longitudinal changes in cortical thickness and its related cognitive decline in patients with multiple system atrophy.
- Author
-
Mun Kyung Sunwoo, Hyuk Jin Yun, Song, Sook K., Ji Hyun Ham, Jin Yong Hong, Lee, Ji E., Lee, Hye S., Sohn, Young H., Jong-Min Lee, and Phil Hyu Lee
- Subjects
BRAIN diseases ,ATROPHY ,PROGNOSIS ,NEURODEGENERATION ,COGNITION disorders ,MESENCHYMAL stem cells - Abstract
Multiple system atrophy (MSA) is an adult-onset, sporadic neurodegenerative disease. Because the prognosis of MSA is fatal, neuroprotective or regenerative strategies may be invaluable in MSA treatment. Previously, we obtained clinical and imaging evidence that mesenchymal stem cell (MSC) treatment could have a neuroprotective role in MSA patients. In the present study, we evaluated the effects of MSC therapy on longitudinal changes in subcortical deep gray matter volumes and cortical thickness and their association with cognitive performance. Clinical and imaging data were obtained from our previous randomized trial of autologous MSC in MSA patients. During 1-year follow-up, we assessed longitudinal differences in automatic segmentation-based subcortical deep gray matter volumes and vertex-wise cortical thickness between placebo (n = 15) and MSC groups (n = 11). Next, we performed correlation analysis between the changes in cortical thickness and changes in the Korean version of the Montreal Cognitive Assessment (MoCA) scores and cognitive performance of each cognitive subdomain using a multiple, comparison correction. There were no significant differences in age at baseline, age at disease onset, gender ratio, disease duration, clinical severity, MoCA score, or education level between the groups. The automated subcortical volumetric analysis revealed that the changes in subcortical deep gray matter volumes of the caudate, putamen, and thalamus did not differ significantly between the groups. The areas of cortical thinning over time in the placebo group were more extensive, including the frontal, temporal, and parietal areas, whereas these areas in the MSC group were less extensive. Correlation analysis indicated that declines in MoCA scores and phonemic fluency during the follow-up period were significantly correlated with cortical thinning of the frontal and posterior temporal areas and anterior temporal areas in MSA patients, respectively. In contrast, no significant correlations were observed in the MSC group. These results suggest that MSC treatment in patients with MSA may modulate cortical thinning over time and related cognitive performance, inferring a future therapeutic candidate for cognitive disorders. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.