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290 results on '"Huang, Lining"'

57. Pityriasis rotunda.

Author

Li, Guomin, Xu, Zhijun, Huang, Lining, and Xue, Ruzeng

Subjects
HAIR follicles, RINGWORM, PATIENT compliance, LITERATURE reviews, ANTIFUNGAL agents
Published
2023
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58. Both Age and Disease Duration are Associated with Clinical Phenotype of Hori’s Nevus in Chinese: A Retrospective Analysis of 497 Cases

Author

Zhong,Yiping, Huang,Lining, Yan,Tingting, Chen,Yongjun, Yang,Bin, Man,Mao-Qiang, Zhong,Yiping, Huang,Lining, Yan,Tingting, Chen,Yongjun, Yang,Bin, and Man,Mao-Qiang

Abstract

Yiping Zhong,* Lining Huang,* Tingting Yan, Yongjun Chen, Bin Yang, Mao-Qiang Man Aesthetic Department, Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510091, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mao-Qiang Man; Bin YangDermatology Hospital, Southern Medical University, Guangzhou 510091, People’s Republic of ChinaTel +86-20-87257353Email mqman@hotmail.com; yangbin101@hotmail.comBackground: Hori’s nevus is a common pigmented disorder on the face, preferentially in females. The clinical features have not been well characterized.Aim: To characterize the clinical features of Hori’s nevus in Chinese adults.Subjects and Methods: Data were collected from files of patients who visited our hospital from 2015 to 2018. Age- and disease duration-related characteristics were analyzed.Results: A total of 497 patients, including 486 females and 11 males, were included in this analysis. One fifth of the patients had a family history of Hori’s nevus. Over 70% of patients were aged 21– 30 years. Age at onset was comparable between males and females (20.64 ± 1.01 vs 18.99 ± 0.24). Out of 497 subjects, 218 subjects (44%) displayed yellow-brown lesions while blue-brown lesions wwere observed in 103 subjects (21%). The rest (176 cases, 35%) showed slate-grey lesions. Involvement in the zygomatic area was observed in 496/497 subjects. Involvement in a single area accounted for 74% of patients, while two areas were involved in 19% of patients. The number of involved areas correlated positively with disease duration. However, the proportion of subjects with yellow-brown lesions correlated negatively with disease duration, while the proportion of subjects with slate-grey lesions correlated positively with disease duration. The proportion of subjects with lesions involving the lower eyelids, the root of the nose, the temple and

Published
2021

60. A Circular RNA, Cholangiocarcinoma‐Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers

Author

Xu, Yi, primary, Leng, Kaiming, additional, Yao, Yue, additional, Kang, Pengcheng, additional, Liao, Guanqun, additional, Han, Yi, additional, Shi, Guangjun, additional, Ji, Daolin, additional, Huang, Peng, additional, Zheng, Wangyang, additional, Li, Zhenglong, additional, Li, Jinglin, additional, Huang, Lining, additional, Yu, Liang, additional, Zhou, Yongxu, additional, Jiang, Xingming, additional, Wang, Hao, additional, Li, Chunlong, additional, Su, Zhilei, additional, Tai, Sheng, additional, Zhong, Xiangyu, additional, Wang, Zhidong, additional, and Cui, Yunfu, additional

Published
2021
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71. NcRNAs and Cholangiocarcinoma

Author

Xu yi, Li Zhenglong, Ji Daolin, Jiang Xingming, Cui Yunfu, Zheng Wangyang, and Huang Lining

Subjects
0301 basic medicine, Poor prognosis, fungi, Cancer, RNA, Review, Computational biology, Biology, Non-coding RNA, medicine.disease, Cholangiocarcinoma, Biliary malignancy, 03 medical and health sciences, 030104 developmental biology, Oncology, microRNA, Therapeutic targets, Clinical value, medicine, Circular RNAs, Biomarkers, Non-noncoding RNAs
Abstract

Cholangiocarcinoma (CCA) is the most common primary biliary malignancy with poor prognosis. Less understanding of its etiology and pathogenesis makes the diagnosis and therapy difficult. Recently, accumulating evidences have demonstrated that deregulated expression of non-coding RNAs (ncRNAs) is closely associated with the etiopathogenesis of CCA. NcRNAs which lack open reading frame are a heterogeneous class of transcribed RNA molecules, including microRNAs, long non-coding RNAs and circular RNAs. Several studies have shown ncRNAs dysregulation is a common central event occurring in CCA and has the potential of being therapy targets. Moreover, ncRNAs can be easily detected in cancer tissues and biofluids, representing valuable tools for diagnosis. In this review, we illustrate the role of ncRNA in the CCA and discuss their potential clinical value.

Published
2018
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72. Additional file 3 of Linc00473 potentiates cholangiocarcinoma progression by modulation of DDX5 expression via miR-506 regulation

Author

Huang, Lining, Xingming Jiang, Zhenglong Li, Jinglin Li, Lin, Xuan, Zengtao Hu, and Yunfu Cui

Abstract

Additional file 3: Fig. S2. a Western blot assay examined DDX5 protein level after transfection with miRNA NC or miR-506 mimics. b Western blot detected DDX5 expression by linc00473 depletion. c Western blot analysis of DDX5 expressions under linc00473 overexpression.

Published
2020
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76. Multiple verruciform xanthomas following bone marrow transplant

Author

Xue, Ruzeng, Su, Wei, Pei, Xiaoping, Huang, Lining, Elbendary, Amira, and Chen, Zhiqiang

Subjects
Health
Abstract

Byline: Ruzeng. Xue, Wei. Su, Xiaoping. Pei, Lining. Huang, Amira. Elbendary, Zhiqiang. Chen Sir, Verruciform xanthoma is a rare benign mucocutaneous lesion which was first described by Shafer in 1971. [...]

Published
2016

77. Application of wetting agent in water injection of hydrophobic and difficult permeability coal seam

Author

Huang Lining

Subjects
Permeability (earth sciences), animal structures, Materials science, business.industry, Water injection (oil production), embryonic structures, otorhinolaryngologic diseases, Coal mining, Wetting, Composite material, business, complex mixtures, respiratory tract diseases
Abstract

On the basis of introducing the mechanism of increasing permeability of wetting agent, taking the comprehensive excavation face of hydrophobic and difficult to penetrate coal seam as the test object, through the test of capillary reverse osmosis in the laboratory, the economic and reasonable concentration of 0.6% wetting agent solution for coal seam water injection is determined. In the field, we use clear water and wetting agent solution to carry out the coal seam water injection test, and make a comparative analysis of the technical effect of coal seam water injection. Using clear water to carry out coal seam water injection, the coal seam wetting radius is less than 0.5m, using wetting agent solution to carry out coal seam water injection, the coal seam wetting radius can reach more than 1.5m. The efficiency of water injection with wetting agent solution is 43.06% higher than that with clean water.

Published
2021
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82. The protective effect of the Rho-kinase inhibitor hydroxyfasudil on propofol-induced hippocampal neuron apoptosis in neonatal rats

Author

Li, Xuze, Huang, Lining, Zhao, Zhifang, Bo, Lijun, Kang, Rongtian, Yang, Jiaojiao, and Dong, Zhenming

Subjects
Original Article
Abstract

Propofol is widely applied for anesthesia induction in pediatric patients. However, accumulating evidence has proved that propofol is neurotoxic to the immature or developing brain. In the present study, we found that hydroxyfasudil, a specific inhibitor of Rho kinase, alleviated the apoptotic neurodegeneration induced by propofol in the developing rat brain. A spatial probe test and Morris water maze test revealed that hydroxyfasudil showed a potential improvement of the tendency towards cognitive impairments induced by propofol. Mechanistically, hydroxyfasudil markedly ameliorated the activation of RhoA and the expression of Rock1, Rock2, Bak, Bax, and Bad induced by propofol and rescued the expression of Bcl2 suppressed by propofol. Our findings suggest that hydroxyfasudil may serve as an effective agent to reduce the propofol-induced neurotoxic effects in pediatric medical procedures.

Published
2018

88. The efficacy of intense pulsed light for Becker's nevus: A retrospective analysis of 45 cases.

Author

Zhong, Yiping, Huang, Lining, Chen, Yongjun, Yan, Tingting, Yang, Bin, and Man, Mao‐Qiang

Subjects
*NEVUS, *HYPERTROPHIC scars, *HYPERTRICHOSIS, *RETROSPECTIVE studies, *CASE studies, *ANIMAL coloration
Abstract

Background: Becker's nevus is a common skin disorder. Lasers and light instruments are the major modalities for the treatment of Becker's nevus, but the outcomes were mixed. Objective: To evaluate the efficacy of the intense pulsed light for Becker's nevus in a large Chinese cohort. Methods: We retrospectively analyzed the efficacy of the intense pulsed light for Becker's nevus in a single center. Results: A total of 45 patients, including 26 males and 19 females (male to female ratio = 1.4), aged 5‐42 years, were included in this analysis. Twenty‐seven patients (60%) were with hypertrichosis. Treatments with intense pulsed light resulted in over 75% improvements in pigmentation and hair density in 1 and 2 cases, respectively. One patient displayed 51%‐75% reductions in hair density. The rest displayed ≤50% improvements in pigmentation and hair density. Recurrence occurred in all cases within 6 months after the last treatment. Adverse reactions were temporary and mild hypopigmentation, hyperpigmentation, hypertrophic scar, pain, and erythema. Conclusion: Intense pulsed light does not exhibit long‐term benefits for Becker's nevus. Further studies in the large cohort are still required to validate the present results. Moreover, whether changes in the treatment parameters can improve the efficacy of intense pulsed light remains to be explored. [ABSTRACT FROM AUTHOR]

Published
2021
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98. Ketamine destabilizes growth of dendritic spines in developing hippocampal neurons in vitro via a Rho-dependent mechanism.

Author

Jiang, Sufang, Hao, Zimiao, Li, Xuze, Bo, Lijun, Zhang, Rui, Wang, Ying, Duan, Xiaofeng, Kang, Rongtian, and Huang, Lining

Subjects
KETAMINE abuse, DENDRITIC spines, HIPPOCAMPAL innervation, JAK-STAT pathway, NEURAL development
Abstract

The safety of anesthetics on the developing brain has caused concern. Ketamine, an N-methyl-D-aspartate receptor antagonist, is widely used as a general pediatric anesthetic. Recent studies suggested that ketamine alters the plasticity of dendritic spines in the developing brain and may be an important contributing factor to learning and cognitive impairment. However, the underlying molecular mechanism remains poorly understood. Therefore, the aim of the present study was to investigate the effect of ketamine on the plasticity of dendritic spines in cultured hippocampal neurons and the potential underlying mechanisms. After 5 days in vitro, rat hippocampal neurons were exposed to different concentrations (100, 300 and 500 µM) of ketamine for 6 h. Ketamine decreased the number and length of dendritic spines in a dose-dependent manner. Ketamine at a concentration of 300 µM caused an upregulation of transforming protein RhoA (RhoA) and Rho-associated kinase (ROCK) protein. These effects were inhibited by the ROCK inhibitor Y27632. These results suggested that ketamine induces loss and shortening of dendritic spines in hippocampal neurons via activation of the RhoA/ROCK signaling pathway. [ABSTRACT FROM AUTHOR]

Published
2018
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