483 results on '"Hsiao, Albert"'
Search Results
52. Molecular Imaging of the Transplanted Heart: A Mechanistic Approach to Graft Survival
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Stendardi, William, Kim, Paul, and Hsiao, Albert
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Bioengineering ,Organ Transplantation ,Transplantation ,Cardiovascular ,Biomedical Imaging ,Heart Disease ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Cardiac transplant ,Molecular imaging ,Acute cellular rejection ,Cardiac allograft vasculopathy ,Heart failure - Published
- 2017
53. Role of Pulse Pressure and Geometry of Primary Entry Tear in Acute Type B Dissection Propagation
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Peelukhana, Srikara V, Wang, Yanmin, Berwick, Zachary, Kratzberg, Jarin, Krieger, Joshua, Roeder, Blayne, Cloughs, Rachel E, Hsiao, Albert, Chambers, Sean, and Kassab, Ghassan S
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Fluid Mechanics and Thermal Engineering ,Engineering ,Animals ,Aorta ,Thoracic ,Aortic Rupture ,Blood Pressure ,Models ,Cardiovascular ,Pulse ,Swine ,Pulse pressure ,Circumferential dissection ,Axial dissection ,Depth of dissection ,Bench-models ,Medical and Health Sciences ,Biomedical Engineering ,Biomedical engineering - Abstract
The hemodynamic and geometric factors leading to propagation of acute Type B dissections are poorly understood. The objective is to elucidate whether geometric and hemodynamic parameters increase the predilection for aortic dissection propagation. A pulse duplicator set-up was used on porcine aorta with a single entry tear. Mean pressures of 100 and 180 mmHg were used, with pulse pressures ranging from 40 to 200 mmHg. The propagation for varying geometric conditions (%circumference of the entry tear: 15-65%, axial length: 0.5-3.2 cm) were tested for two flap thicknesses (1/3rd and 2/3rd of the thickness of vessel wall, respectively). To assess the effect of pulse and mean pressure on flap dynamics, the %true lumen (TL) cross-sectional area of the entry tear were compared. The % circumference for propagation of thin flap (47 ± 1%) was not significantly different (p = 0.14) from thick flap (44 ± 2%). On the contrary, the axial length of propagation for thin flap (2.57 ± 0.15 cm) was significantly different (p
- Published
- 2017
54. Multiplexed genome imaging and analysis
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Jia, Bojing Blair, Ren, Bing1, Hsiao, Albert, Jia, Bojing Blair, Jia, Bojing Blair, Ren, Bing1, Hsiao, Albert, and Jia, Bojing Blair
- Abstract
Chromatin encapsulates not only genomic sequence information but also its structural organization. Chromosome folding patterns may juxtapose distal functional elements of DNA in space and are thought to regulate gene expression. Directly visualizing chromosome architecture to study this grammar of chromosome folding has been but a longstanding ambition in the field of epigenetics. An emergent imaging technology called multiplexed DNA-FISH has made it possible to localize the positions of thousands of genomic loci with nanometer precision inside single cells. Given a cell’s ploidy, deriving chromatin conformations from this data initially assumed detecting a fixed number of bright signals and connecting them in sequential genomic order. But during cell cycle chromosomes copies are subject to change; it is also subject to copy number variations such as amplifications or deletions; it is subjected further still to technical noise such as false positives appearing as true signal, or signal dropout. In my thesis, I sought to develop a different framework that accounts for various sources of noise that have gone unappreciated in multiplexed DNA imaging, to show that by embracing the complexity of noise we can in fact uncover new biology previously unseen. First, I describe spatial genome alignment and its derivative polymer fiber karyotyping, methods for accurately resolving chromatin structures in a copy number agnostic fashion. We apply this method to multiplexed DNA-FISH data of mouse embryonic stem cells (mESC) and the mouse cortex. In dividing mESCs, we provide the first reconstructions of tightly intertwined sister chromatids decondensed in interphase – convoluted structures which previously could not be parsed by computer vision or by human eye. We go on to uncover unusual structures such as replicated homologs interacting in one single chromosome territory, suggestive of mitotic crossover. In the mouse cortex, we uncover tightly paired chromosomes in non-dividing
- Published
- 2024
55. What Accuracy Is Required for Automated CMR? A Comparison Between Automated and Operator Recognition of the Valve in a Short Axis Stack
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Gorodezky, Margarita, primary, Vinsky, Michael, additional, Ma, Junjie, additional, Nikbeh, Fara, additional, Thomas, Mary, additional, Solana, Ana Beatriz, additional, Wang, Haonan, additional, Wang, Pingni, additional, Quarterman, Patrick, additional, Ali, Eman, additional, Hoertemoeller, Martina, additional, Kaushik, Sandeep, additional, Rettmann, Dan, additional, Hsiao, Albert, additional, Janich, Martin, additional, and Delso, Gaspar, additional
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- 2024
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56. Utilization of 4D Flow Imaging to Create a 5 Foot Tall Heart for a Museum Exhibit
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Jockisch, Reid, primary, Davey, Connor, additional, Pieta, Sister M., additional, Conger, Bill, additional, Hsiao, Albert, additional, and Bramlet, Matthew, additional
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- 2024
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- View/download PDF
57. Qualitative grading of aortic regurgitation: a pilot study comparing CMR 4D flow and echocardiography
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Chelu, Raluca G, van den Bosch, Annemien E, van Kranenburg, Matthijs, Hsiao, Albert, van den Hoven, Allard T, Ouhlous, Mohamed, Budde, Ricardo PJ, Beniest, Kirsten M, Swart, Laurens E, Coenen, Adriaan, Lubbers, Marisa M, Wielopolski, Piotr A, Vasanawala, Shreyas S, Roos-Hesselink, Jolien W, and Nieman, Koen
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Clinical Research ,Cardiovascular ,Biomedical Imaging ,Heart Disease ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Adult ,Aortic Valve ,Aortic Valve Insufficiency ,Female ,Humans ,Imaging ,Three-Dimensional ,Magnetic Resonance Imaging ,Male ,Pilot Projects ,Reproducibility of Results ,Sensitivity and Specificity ,Severity of Illness Index ,Cardiac ,Phase contrast ,CMR 4D flow imaging ,Eddy currents correction ,Aortic regurgitation ,Flow visualization ,Cardiorespiratory Medicine and Haematology ,Nuclear Medicine & Medical Imaging ,Cardiovascular medicine and haematology - Abstract
Over the past 10 years there has been intense research in the development of volumetric visualization of intracardiac flow by cardiac magnetic resonance (CMR).This volumetric time resolved technique called CMR 4D flow imaging has several advantages over standard CMR. It offers anatomical, functional and flow information in a single free-breathing, ten-minute acquisition. However, the data obtained is large and its processing requires dedicated software. We evaluated a cloud-based application package that combines volumetric data correction and visualization of CMR 4D flow data, and assessed its accuracy for the detection and grading of aortic valve regurgitation using transthoracic echocardiography as reference. Between June 2014 and January 2015, patients planned for clinical CMR were consecutively approached to undergo the supplementary CMR 4D flow acquisition. Fifty four patients(median age 39 years, 32 males) were included. Detection and grading of the aortic valve regurgitation using CMR4D flow imaging were evaluated against transthoracic echocardiography. The agreement between 4D flow CMR and transthoracic echocardiography for grading of aortic valve regurgitation was good (j = 0.73). To identify relevant,more than mild aortic valve regurgitation, CMR 4D flow imaging had a sensitivity of 100 % and specificity of 98 %. Aortic regurgitation can be well visualized, in a similar manner as transthoracic echocardiography, when using CMR 4D flow imaging.
- Published
- 2016
58. Improved quantification and mapping of anomalous pulmonary venous flow with four‐dimensional phase‐contrast MRI and interactive streamline rendering
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Hsiao, Albert, Yousaf, Ufra, Alley, Marcus T, Lustig, Michael, Chan, Frandics Pak, Newman, Beverley, and Vasanawala, Shreyas S
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease ,Bioengineering ,Cardiovascular ,Biomedical Imaging ,Pediatric ,Clinical Research ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Adolescent ,Adult ,Algorithms ,Blood Flow Velocity ,Child ,Child ,Preschool ,Humans ,Image Enhancement ,Imaging ,Three-Dimensional ,Infant ,Magnetic Resonance Angiography ,Observer Variation ,Pulmonary Veins ,Reproducibility of Results ,Sensitivity and Specificity ,User-Computer Interface ,Young Adult ,flow ,pulmonary ,shunt ,structural ,veins ,Physical Sciences ,Engineering ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
BackgroundCardiac MRI is routinely performed for quantification of shunt flow in patients with anomalous pulmonary veins, but can be technically-challenging to perform. Four-dimensional phase-contrast (4D-PC) MRI has potential to simplify this exam. We sought to determine whether 4D-PC may be a viable clinical alternative to conventional 2D phase-contrast MR imaging.MethodsWith institutional review board approval and HIPAA-compliance, we retrospectively identified all patients with anomalous pulmonary veins who underwent cardiac MRI at either 1.5 Tesla (T) or 3T with parallel-imaging compressed-sensing (PI-CS) 4D-PC between April, 2011 and October, 2013. A total of 15 exams were included (10 male, 5 female). Algorithms for interactive streamline visualization were developed and integrated into in-house software. Blood flow was measured at the valves, pulmonary arteries and veins, cavae, and any associated shunts. Pulmonary veins were mapped to their receiving atrial chamber with streamlines. The intraobserver, interobserver, internal consistency of flow measurements, and consistency with conventional MRI were then evaluated with Pearson correlation and Bland-Altman analysis.ResultsTriplicate measurements of blood flow from 4D-PC were highly consistent, particularly at the aortic and pulmonary valves (cv 2-3%). Flow measurements were reproducible by a second observer (ρ = 0.986-0.999). Direct measurements of shunt volume from anomalous veins and intracardiac shunts matched indirect estimates from the outflow valves (ρ = 0.966). Measurements of shunt fraction using 4D-PC using any approach were more consistent with ventricular volumetric displacements than conventional 2D-PC (ρ = 0.972-0.991 versus 0.929).ConclusionShunt flow may be reliably quantified with 4D-PC MRI, either indirectly or with detailed delineation of flow from multiple shunts. The 4D-PC may be a more accurate alternative to conventional MRI.
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- 2015
59. Congenital heart disease assessment with 4D flow MRI
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Vasanawala, Shreyas S, Hanneman, Kate, Alley, Marcus T, and Hsiao, Albert
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Biomedical Imaging ,Pediatric Research Initiative ,Congenital Structural Anomalies ,Heart Disease ,Pediatric ,Cardiovascular ,Clinical Research ,Algorithms ,Cardiac-Gated Imaging Techniques ,Heart Defects ,Congenital ,Humans ,Image Enhancement ,Image Interpretation ,Computer-Assisted ,Imaging ,Three-Dimensional ,Magnetic Resonance Angiography ,Magnetic Resonance Imaging ,Cine ,Myocardial Perfusion Imaging ,Reproducibility of Results ,Sensitivity and Specificity ,4D flow ,cardiac ,congenital ,phase contrast ,time-resolved ,Physical Sciences ,Engineering ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
With improvements in surgical and medical management, patients with congenital heart disease (CHD) are often living well into adulthood. MRI provides critical data for diagnosis and monitoring of these patients, yielding information on cardiac anatomy, blood flow, and cardiac function. Though historically these exams have been complex and lengthy, four-dimensional (4D) flow is emerging as a single fast technique for comprehensive assessment of CHD. The 4D flow consists of a volumetric time-resolved acquisition that is gated to the cardiac cycle, providing a time-varying vector field of blood flow as well as registered anatomic images. In this article, we provide an overview of MRI evaluation of congenital heart disease by means of example of three relatively common representative conditions: tetralogy of Fallot, aortic coarctation, and anomalous pulmonary venous drainage. Then 4D flow data acquisition, data correction, and postprocessing techniques are reviewed. We conclude with several examples that highlight the comprehensive nature of the evaluation of congenital heart disease with 4D flow.
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- 2015
60. Clinical performance of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced pediatric abdominal MR angiography
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Zhang, Tao, Yousaf, Ufra, Hsiao, Albert, Cheng, Joseph Y, Alley, Marcus T, Lustig, Michael, Pauly, John M, and Vasanawala, Shreyas S
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Biomedical Imaging ,Pediatric ,Clinical Research ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Abdomen ,Adolescent ,Arteries ,Child ,Child ,Preschool ,Contrast Media ,Female ,Humans ,Image Enhancement ,Image Interpretation ,Computer-Assisted ,Imaging ,Three-Dimensional ,Infant ,Infant ,Newborn ,Magnetic Resonance Angiography ,Male ,Reproducibility of Results ,Respiratory Mechanics ,Sensitivity and Specificity ,Spatio-Temporal Analysis ,Children ,Compressed sensing ,Magnetic resonance angiography ,Parallel imaging ,Spatiotemporal acceleration ,Paediatrics and Reproductive Medicine ,Nuclear Medicine & Medical Imaging - Abstract
BackgroundPediatric contrast-enhanced MR angiography is often limited by respiration, other patient motion and compromised spatiotemporal resolution.ObjectiveTo determine the reliability of a free-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography method for depicting abdominal arterial anatomy in young children.Materials and methodsWith IRB approval and informed consent, we retrospectively identified 27 consecutive children (16 males and 11 females; mean age: 3.8 years, range: 14 days to 8.4 years) referred for contrast-enhanced MR angiography at our institution, who had undergone free-breathing spatiotemporally accelerated time-resolved contrast-enhanced MR angiography studies. A radio-frequency-spoiled gradient echo sequence with Cartesian variable density k-space sampling and radial view ordering, intrinsic motion navigation and intermittent fat suppression was developed. Images were reconstructed with soft-gated parallel imaging locally low-rank method to achieve both motion correction and high spatiotemporal resolution. Quality of delineation of 13 abdominal arteries in the reconstructed images was assessed independently by two radiologists on a five-point scale. Ninety-five percent confidence intervals of the proportion of diagnostically adequate cases were calculated. Interobserver agreements were also analyzed.ResultsEleven out of 13 arteries achieved acceptable image quality (mean score range: 3.9-5.0) for both readers. Fair to substantial interobserver agreement was reached on nine arteries.ConclusionFree-breathing spatiotemporally accelerated 3-D time-resolved contrast-enhanced MR angiography frequently yields diagnostic image quality for most abdominal arteries in young children.
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- 2015
61. Ferumoxytol as an off-label contrast agent in body 3T MR angiography: a pilot study in children
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Ruangwattanapaisarn, Nichanan, Hsiao, Albert, and Vasanawala, Shreyas S
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Pediatric ,Biomedical Imaging ,Clinical Research ,Cardiovascular ,Adolescent ,Cardiac-Gated Imaging Techniques ,Child ,Child ,Preschool ,Contrast Media ,Feasibility Studies ,Female ,Ferrosoferric Oxide ,Humans ,Infant ,Infant ,Newborn ,Magnetic Resonance Angiography ,Male ,Off-Label Use ,Pilot Projects ,Retrospective Studies ,Signal-To-Noise Ratio ,Paediatrics and Reproductive Medicine ,Nuclear Medicine & Medical Imaging ,Clinical sciences ,Paediatrics - Abstract
BackgroundFerumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle agent used to treat iron deficiency anemia in adults with chronic kidney disease.ObjectiveWe aim to determine the feasibility of using ferumoxytol for clinical pediatric cardiac and vascular imaging.Material and methodsWe retrospectively identified 23 consecutive children who underwent MRI with ferumoxytol (11 males; mean age: 7.4 years, range: 3 days-18 years), yielding 12 abdominal MR angiography and 15 cardiac MRI studies. Medical records were reviewed for the clinical indication, ferumoxytol dose, injection rate, sedation and any complication. A two-reader consensus scored the images on a five-point scale for overall image quality and delineation of various anatomical structures. Signal-to-background ratios for abdominal aorta and inferior vena cava for abdominal cases and blood pool-myocardium contrast ratios for cardiac cases were calculated. The confidence intervals for obtaining a score of three or above for each image parameter were calculated by using adjusted Wald method.ResultsFor abdominal MR angiography, average scores for overall image quality, as well as delineation of the hepatic artery, superior mesenteric artery, renal artery and veins were 4.5, 4.3, 4.3, 3.7 and 4.7, respectively. For cardiac exams, the average scores for overall image quality, systemic arteries, pulmonary arteries, pulmonary veins, valves and ventricles were 4.4, 4.6, 4.1, 4.8, 4.1 and 4.7, respectively. For all parameters, the lower bound for the proportion of cases to have a score of 3 or above was 65%. Signal-to-background ratios for aorta and abdominal veins averaged 86 +/- 74 and 86 +/- 77 for full-dose images, and 23 and 18 for half-dose images, respectively. Mean blood pool to myocardium contrast ratio was 3:3.ConclusionFerumoxytol can provide excellent image quality for pediatric body MR angiography/MR venography at a dose of 1.5 or 3 mg Fe/kg. Further investigation should be directed toward understanding the lowest dose that can be administered.
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- 2015
62. Inlet and outlet valve flow and regurgitant volume may be directly and reliably quantified with accelerated, volumetric phase‐contrast MRI
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Hsiao, Albert, Tariq, Umar, Alley, Marcus T, Lustig, Michael, and Vasanawala, Shreyas S
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Heart Disease ,Clinical Research ,Congenital Structural Anomalies ,Cardiovascular ,Pediatric ,Biomedical Imaging ,Adolescent ,Algorithms ,Child ,Child ,Preschool ,Feasibility Studies ,Female ,Heart Defects ,Congenital ,Heart Valve Diseases ,Humans ,Image Interpretation ,Computer-Assisted ,Infant ,Magnetic Resonance Angiography ,Male ,Retrospective Studies ,flow ,structural ,tricuspid ,mitral ,regurgitation ,Physical Sciences ,Engineering ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging ,Clinical sciences - Abstract
PurposeTo determine whether it is feasible to use solely an accelerated 4D phase-contrast magnetic resonance imaging (4D-PC MRI) acquisition to quantify net and regurgitant flow volume through each of the cardiac valves.Materials and methodsAccelerated, 4D-PC MRI examinations performed between March 2010 through June 2011 as part of routine MRI examinations for congenital, structural heart disease were retrospectively reviewed and analyzed using valve-tracking visualization and quantification algorithms developed in Java and OpenGL. Excluding patients with transposition or single ventricle physiology, a total of 34 consecutive pediatric patients (19 male, 15 female; mean age 6.9 years; age range 10 months to 15 years) were identified. 4D-PC flow measurements were compared at each valve and against routine measurements from conventional cardiac MRI using Bland-Altman and Pearson correlation analysis.ResultsInlet and outlet valve net flow were highly correlated between all valves (P = 0.940-0.985). The sum of forward flow at the outlet valve and regurgitant flow at the inlet valve were consistent with volumetric displacements in each ventricle (P = 0.939-0.948). These were also highly consistent with conventional planar MRI measurements with net flow (P = 0.923-0.935) and regurgitant fractions (P = 0.917-0.972) at the outlet valve and ventricular volumes (P = 0.925-0.965).ConclusionIt is possible to obtain consistent measurements of net and regurgitant blood flow across the inlet and outlet valves relying solely on accelerated 4D-PC. This may facilitate more efficient clinical quantification of valvular regurgitation.
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- 2015
63. Robust 4D flow denoising using divergence‐free wavelet transform
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Ong, Frank, Uecker, Martin, Tariq, Umar, Hsiao, Albert, Alley, Marcus T, Vasanawala, Shreyas S, and Lustig, Michael
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Communications Engineering ,Engineering ,Algorithms ,Artifacts ,Blood Flow Velocity ,Child ,Coronary Circulation ,Female ,Humans ,Image Enhancement ,Image Interpretation ,Computer-Assisted ,Magnetic Resonance Angiography ,Male ,Reproducibility of Results ,Sensitivity and Specificity ,Signal-To-Noise Ratio ,Wavelet Analysis ,four-dimensional flow ,wavelet denoising ,divergence-free ,Biomedical Engineering ,Nuclear Medicine & Medical Imaging ,Biomedical engineering - Abstract
PurposeTo investigate four-dimensional flow denoising using the divergence-free wavelet (DFW) transform and compare its performance with existing techniques.Theory and methodsDFW is a vector-wavelet that provides a sparse representation of flow in a generally divergence-free field and can be used to enforce "soft" divergence-free conditions when discretization and partial voluming result in numerical nondivergence-free components. Efficient denoising is achieved by appropriate shrinkage of divergence-free wavelet and nondivergence-free coefficients. SureShrink and cycle spinning are investigated to further improve denoising performance.ResultsDFW denoising was compared with existing methods on simulated and phantom data and was shown to yield better noise reduction overall while being robust to segmentation errors. The processing was applied to in vivo data and was demonstrated to improve visualization while preserving quantifications of flow data.ConclusionDFW denoising of four-dimensional flow data was shown to reduce noise levels in flow data both quantitatively and visually.
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- 2015
64. Artificial intelligence and machine learning in aortic disease
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Hahn, Lewis D., Baeumler, Kathrin, and Hsiao, Albert
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- 2021
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65. Evaluation of Valvular Insufficiency and Shunts with Parallel-imaging Compressed-sensing 4D Phase-contrast MR Imaging with Stereoscopic 3D Velocity-fusion Volume-rendered Visualization
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Hsiao, Albert, Lustig, Michael, Alley, Marcus T, Murphy, Mark J, and Vasanawala, Shreyas S
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Cardiovascular ,Biomedical Imaging ,Clinical Research ,Heart Disease ,Detection ,screening and diagnosis ,4.2 Evaluation of markers and technologies ,Adolescent ,Algorithms ,Child ,Child ,Preschool ,Contrast Media ,Data Compression ,Echocardiography ,Doppler ,Color ,Female ,Heart Defects ,Congenital ,Humans ,Image Enhancement ,Image Interpretation ,Computer-Assisted ,Imaging ,Three-Dimensional ,Infant ,Magnetic Resonance Imaging ,Male ,Retrospective Studies ,Sensitivity and Specificity ,Young Adult ,Medical and Health Sciences ,Nuclear Medicine & Medical Imaging - Abstract
PurposeTo assess the potential of compressed-sensing parallel-imaging four-dimensional (4D) phase-contrast magnetic resonance (MR) imaging and specialized imaging software in the evaluation of valvular insufficiency and intracardiac shunts in patients with congenital heart disease.Materials and methodsInstitutional review board approval was obtained for this HIPAA-compliant study. Thirty-four consecutive retrospectively identified patients in whom a compressed-sensing parallel-imaging 4D phase-contrast sequence was performed as part of routine clinical cardiac MR imaging between March 2010 and August 2011 and who had undergone echocardiography were included. Multiplanar, volume-rendered, and stereoscopic three-dimensional velocity-fusion visualization algorithms were developed and implemented in Java and OpenGL. Two radiologists independently reviewed 4D phase-contrast studies for each of 34 patients (mean age, 6 years; age range, 10 months to 21 years) and tabulated visible shunts and valvular regurgitation. These results were compared with color Doppler echocardiographic and cardiac MR imaging reports, which were generated without 4D phase-contrast visualization. Cohen κ statistics were computed to assess interobserver agreement and agreement with echocardiographic results.ResultsThe 4D phase-contrast acquisitions were performed, on average, in less than 10 minutes. Among 123 valves seen in 34 4D phase-contrast studies, 29 regurgitant valves were identified, with good agreement between observers (k=0.85). There was also good agreement with the presence of at least mild regurgitation at echocardiography (observer 1, κ=0.76; observer 2, κ=0.77) with high sensitivity (observer 1, 75%; observer 2, 82%) and specificity (observer 1, 97%; observer 2, 95%) relative to the reference standard. Eight intracardiac shunts were identified, four of which were not visible with conventional cardiac MR imaging but were detected with echocardiography. No intracardiac shunts were found with echocardiography alone.ConclusionWith velocity-fusion visualization, the compressed-sensing parallel-imaging 4D phase-contrast sequence can augment conventional cardiac MR imaging by improving sensitivity for and depiction of hemodynamically significant shunts and valvular regurgitation.
- Published
- 2012
66. Cardiac MRI Field Strength: Counterpoint—Image Quality Gains From Higher SNR Are Achievable at 3 T
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You, Sophie, primary and Hsiao, Albert, additional
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- 2023
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67. Deep Learning for Inference of Hepatic Proton-Density Fat Fraction From T1-Weighted In-Phase and Opposed-Phase MRI: Retrospective Analysis of Population-Based Trial Data
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Wang, Kang, primary, Cunha, Guilherme Moura, additional, Hasenstab, Kyle, additional, Henderson, Walter C., additional, Middleton, Michael S., additional, Cole, Shelley A., additional, Umans, Jason G., additional, Ali, Tauqeer, additional, Hsiao, Albert, additional, and Sirlin, Claude B., additional
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- 2023
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68. Bivariate microarray analysis: statistical interpretation of two-channel functional genomics data
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Hsiao, Albert and Subramaniam, Shankar
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Biological Sciences ,Bioinformatics and Computational Biology ,Genetics ,Human Genome ,Biotechnology ,2.5 Research design and methodologies (aetiology) ,Aetiology ,Bioinformatics - Abstract
Conventional statistical methods for interpreting microarray data require large numbers of replicates in order to provide sufficient levels of sensitivity. We recently described a method for identifying differentially-expressed genes in one-channel microarray data 1. Based on the idea that the variance structure of microarray data can itself be a reliable measure of noise, this method allows statistically sound interpretation of as few as two replicates per treatment condition. Unlike the one-channel array, the two-channel platform simultaneously compares gene expression in two RNA samples. This leads to covariation of the measured signals. Hence, by accounting for covariation in the variance model, we can significantly increase the power of the statistical test. We believe that this approach has the potential to overcome limitations of existing methods. We present here a novel approach for the analysis of microarray data that involves modeling the variance structure of paired expression data in the context of a Bayesian framework. We also describe a novel statistical test that can be used to identify differentially-expressed genes. This method, bivariate microarray analysis (BMA), demonstrates dramatically improved sensitivity over existing approaches. We show that with only two array replicates, it is possible to detect gene expression changes that are at best detected with six array replicates by other methods. Further, we show that combining results from BMA with Gene Ontology annotation yields biologically significant results in a ligand-treated macrophage cell system.
- Published
- 2008
69. Kiosk 5R-TC-02 - Utilization of 4D Flow Imaging to Create a 5 Foot Tall Heart for a Museum Exhibit
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Jockisch, Reid, Davey, Connor, Pieta, Sister M., Conger, Bill, Hsiao, Albert, and Bramlet, Matthew
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- 2024
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70. Kiosk 5R-FC-02 - What Accuracy Is Required for Automated CMR? A Comparison Between Automated and Operator Recognition of the Valve in a Short Axis Stack
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Gorodezky, Margarita, Vinsky, Michael, Ma, Junjie, Nikbeh, Fara, Thomas, Mary, Solana, Ana Beatriz, Wang, Haonan, Wang, Pingni, Quarterman, Patrick, Ali, Eman, Hoertemoeller, Martina, Kaushik, Sandeep, Rettmann, Dan, Hsiao, Albert, Janich, Martin, and Delso, Gaspar
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- 2024
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71. Chapter 4 - MRI Neurovascular Evaluation: Blood Flow, Perfusion, Diffusion, and Susceptibility
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Srinivas, Shanmukha, Bolar, Divya S., Ayub, Muhammad Abubakar, Soman, Salil, and Hsiao, Albert
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- 2024
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72. Case 13: Pulmonary Arteritis… The Great CTEPH Mimic
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Kerr, Kim M., primary, Hsiao, Albert, additional, and Auger, William R., additional
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- 2019
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73. Deep Learning Localization of Pneumonia: 2019 Coronavirus (COVID-19) Outbreak
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Hurt, Brian, Kligerman, Seth, and Hsiao, Albert
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- 2020
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74. Cardiac phase estimation using deep learning analysis of pulsed-mode projections: towards autonomous cardiac CT imaging
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Wu, Pengwei, primary, Pack, Jed D., additional, Haneda, Eri, additional, Heukensfeldt Jansen, Isabelle, additional, Claus, Bernhard, additional, Hsiao, Albert, additional, McVeigh, Elliot, additional, and De Man, Bruno, additional
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- 2023
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75. 4D Flow cardiovascular magnetic resonance consensus statement: 2023 update
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Bissell, Malenka M; https://orcid.org/0000-0002-1282-2859, Raimondi, Francesca, Ait Ali, Lamia, Allen, Bradley D, Barker, Alex J, Bolger, Ann, Burris, Nicholas, Carhäll, Carl-Johan, Collins, Jeremy D, Ebbers, Tino, Francois, Christopher J, Frydrychowicz, Alex, Garg, Pankaj, Geiger, Julia; https://orcid.org/0000-0003-3621-9955, Ha, Hojin, Hennemuth, Anja, Hope, Michael D, Hsiao, Albert, Johnson, Kevin, Kozerke, Sebastian, Ma, Liliana E, Markl, Michael, Martins, Duarte, Messina, Marci, Oechtering, Thekla H, van Ooij, Pim, Rigsby, Cynthia, Rodriguez-Palomares, Jose, Roest, Arno A W, Roldán-Alzate, Alejandro, et al, Bissell, Malenka M; https://orcid.org/0000-0002-1282-2859, Raimondi, Francesca, Ait Ali, Lamia, Allen, Bradley D, Barker, Alex J, Bolger, Ann, Burris, Nicholas, Carhäll, Carl-Johan, Collins, Jeremy D, Ebbers, Tino, Francois, Christopher J, Frydrychowicz, Alex, Garg, Pankaj, Geiger, Julia; https://orcid.org/0000-0003-3621-9955, Ha, Hojin, Hennemuth, Anja, Hope, Michael D, Hsiao, Albert, Johnson, Kevin, Kozerke, Sebastian, Ma, Liliana E, Markl, Michael, Martins, Duarte, Messina, Marci, Oechtering, Thekla H, van Ooij, Pim, Rigsby, Cynthia, Rodriguez-Palomares, Jose, Roest, Arno A W, Roldán-Alzate, Alejandro, and et al
- Abstract
Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 '4D Flow CMR Consensus Statement'. We elaborate on 4D Flow CMR sequence options and imaging considerations. The document aims to assist centers starting out with 4D Flow CMR of the heart and great vessels with advice on acquisition parameters, post-processing workflows and integration into clinical practice. Furthermore, we define minimum quality assurance and validation standards for clinical centers. We also address the challenges faced in quality assurance and validation in the research setting. We also include a checklist for recommended publication standards, specifically for 4D Flow CMR. Finally, we discuss the current limitations and the future of 4D Flow CMR. This updated consensus paper will further facilitate widespread adoption of 4D Flow CMR in the clinical workflow across the globe and aid consistently high-quality publication standards.
- Published
- 2023
76. Improving the Fontan: Pre-surgical planning using four dimensional (4D) flow, bio-mechanical modeling and three dimensional (3D) printing
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Hegde, Sanjeet and Hsiao, Albert
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- 2016
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77. Challenges and Opportunities in Medical Artificial Intelligence.
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Tsai, Chieh-Mei, Chao, Chieh-Ju, Chang, Yung-Chun, Jay Kuo, Chung-Chieh, Hsiao, Albert, and Shieh, Alexander
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ARTIFICIAL intelligence ,ROAD maps ,IMAGE processing ,INFORMATION professionals - Abstract
Artificial intelligence (AI) applications in medicine and healthcare have been growing rapidly in recent years. More clinician-scientists have been interested in engaging in the medical AI field. A road map that guides medical professionals and information technologies to enter the field is in demand. An online panel discussion on AI in Healthcare was organized and conducted on May 22nd, 2023. Four panelists with mixed backgrounds were invited to provide their opinions on this topic. They included clinicians in radiology and cardiology and information technologists specialized in image processing, computer vision, and natural language processing. This forum paper recorded the main discussion points. The write-up was also edited and expanded to make their messages more complete in their current form. The content was centered around challenges, opportunities, and future directions in the integration of AI and Healthcare. Besides providing a comprehensive account of different viewpoints, panelists offered practical advice to young clinician-scientists who desire to enter the emerging medical AI field. [ABSTRACT FROM AUTHOR]
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- 2023
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78. Feature Interpretation Using Generative Adversarial Networks (FIGAN): A Framework for Visualizing a CNN’s Learned Features
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Hasenstab, Kyle A., primary, Huynh, Justin, additional, Masoudi, Samira, additional, Cunha, Guilherme M., additional, Pazzani, Michael, additional, and Hsiao, Albert, additional
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- 2023
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79. Deep Learning Phase Error Correction for Cerebrovascular 4D Flow MRI
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Srinivas, Shanmukha, Masutani, Evan, Norbash, Alexander, and Hsiao, Albert
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Deep Learning ,Clinical Research ,Three-Dimensional ,Hemodynamics ,Neurosciences ,Humans ,Reproducibility of Results ,Magnetic Resonance Imaging ,Imaging ,Retrospective Studies - Abstract
Background and Purpose Background phase errors in 4D Flow MRI may negatively impact blood flow quantification. In this study, we assessed their impact on cerebrovascular flow volume measurements, evaluated the benefit of manual image-based correction, and assessed the potential of a convolutional neural network (CNN), a form of deep learning, to directly infer the correction vector field. Methods With IRB waiver of informed consent, we retrospectively identified 96 MRI exams from 48 patients who underwent cerebrovascular 4D Flow MRI from October 2015 to 2020. Flow measurements of the anterior, posterior, and venous circulation were performed to assess inflow-outflow error and the benefit of manual image-based phase error correction. A CNN was then trained to directly infer the phase-error correction field, without segmentation, from 4D Flow volumes to automate correction, reserving from 23 exams for testing. Statistical analyses included Spearman correlation, Bland-Altman, Wilcoxon-signed rank (WSR) and F-tests. Results Prior to correction, there was strong correlation between inflow and outflow (ρ = 0.833–0.947) measurements with the largest discrepancy in the venous circulation. Manual phase error correction improved inflow-outflow correlation (ρ = 0.945–0.981) and decreased variance (p F-test). Fully automated CNN correction was non-inferior to manual correction with no significant differences in correlation (ρ = 0.971 vs ρ = 0.982) or bias (p = 0.82, Wilcoxon-Signed Rank test) of inflow and outflow measurements. Conclusions Residual background phase error can impair inflow-outflow consistency of cerebrovascular flow volume measurements. A CNN can be used to directly infer the phase-error vector field to fully automate phase error correction.
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- 2022
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80. Deep Learning Phase Error Correction for Cerebrovascular 4D Flow MRI
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Srini, Shanmukha, primary, Masutani, Evan, additional, Norbash, Alexander, additional, and Hsiao, Albert, additional
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- 2022
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81. Deep Learning Subtraction Angiography: Improved Generalizability with Transfer Learning
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Crabb, Brendan T., primary, Hamrick, Forrest, additional, Richards, Tyler, additional, Eiswirth, Preston, additional, Noo, Frederic, additional, Hsiao, Albert, additional, and Fine, Gabriel C., additional
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- 2022
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82. Unsupervised Learning Identifies Computed Tomographic Measurements as Primary Drivers of Progression, Exacerbation, and Mortality in Chronic Obstructive Pulmonary Disease
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Yuan, Nancy F., primary, Hasenstab, Kyle, additional, Retson, Tara, additional, Conrad, Douglas J., additional, Lynch, David A., additional, and Hsiao, Albert, additional
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- 2022
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83. A five-dimensional cardiac CT model for generating virtual CT projections for user-defined bolus dynamics and ECG profiles
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Haneda, Eri, primary, Claus, Bernhard, additional, Pack, Jed, additional, Okerlund, Darin, additional, Hsiao, Albert, additional, McVeigh, Elliot, additional, and De Man, Bruno, additional
- Published
- 2022
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84. Estimation of contrast agent concentration from pulsed-mode projections to time contrast-enhanced CT scans
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Heukensfeldt Jansen, Isabelle, primary, Haneda, Eri, additional, Claus, Bernhard, additional, Pack, Jed, additional, Hsiao, Albert, additional, McVeigh, Elliot, additional, and De Man, Bruno, additional
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- 2022
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85. Computationally Efficient Cardiac Views Projection Using 3D Convolutional Neural Networks
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Le, Matthieu, primary, Lieman-Sifry, Jesse, additional, Lau, Felix, additional, Sall, Sean, additional, Hsiao, Albert, additional, and Golden, Daniel, additional
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- 2017
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86. Expert-Informed, User-Centric Explanations for Machine Learning
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Pazzani, Michael, primary, Soltani, Severine, additional, Kaufman, Robert, additional, Qian, Samson, additional, and Hsiao, Albert, additional
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- 2022
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87. Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers
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Mason, Stefanie E., primary, Moreta-Martinez, Rafael, additional, Labaki, Wassim W., additional, Strand, Matthew J., additional, Regan, Elizabeth A., additional, Bon, Jessica, additional, San Jose Estepar, Ruben, additional, Casaburi, Richard, additional, McDonald, Merry-Lynn, additional, Rossiter, Harry B., additional, Make, Barry, additional, Dransfield, Mark T., additional, Han, MeiLan K., additional, Young, Kendra, additional, Curtis, Jeffrey L., additional, Stringer, Kathleen, additional, Kinney, Greg, additional, Hokanson, John E., additional, San Jose Estepar, Raul, additional, Washko, George R., additional, Crapo, James D., additional, Silverman, Edwin K., additional, Cummings, Sara, additional, Madden, Kelley, additional, Make, Barry J., additional, Nabbosa, Juliet, additional, Port, Emily, additional, Rashdi, Serine, additional, Stepp, Lori, additional, Watts, Shandi, additional, Weaver, Michael, additional, Beaty, Terri, additional, Bowler, Russell P., additional, Lynch, David A., additional, Anderson, Gary, additional, Bleecker, Eugene R., additional, Coxson, Harvey O., additional, Crystal, Ronald G., additional, Hogg, James C., additional, Province, Michael A., additional, Rennard, Stephen I., additional, Croxton, Thomas, additional, Gan, Weiniu, additional, Postow, Lisa A., additional, Viviano, Lisa M., additional, Costa-Davis, Corinne, additional, Malanga, Elisha, additional, Prieto, Delia, additional, Tal-Singer, Ruth, additional, Farzadegan, Homayoon, additional, Hadji, Akila, additional, Sathe, Leena, additional, Baraghoshi, David, additional, Chen, Grace, additional, Crooks, James, additional, Knowles, Ruthie, additional, Pratte, Katherine, additional, Wilson, Carla, additional, Zelarney, Pearlanne T., additional, Kechris, Katerina J., additional, Leach, Sonia, additional, Austin, Erin E., additional, Czizik, Annika, additional, Kinney, Gregory, additional, Li, Yisha, additional, Lutz, Sharon M., additional, Ragland, Margaret F., additional, Richmond, Nicole, additional, Young, Kendra A., additional, Cho, Michael, additional, Castaldi, Peter J., additional, Glass, Kimberly, additional, Hersh, Craig, additional, Kim, Wonji, additional, Liu, Yang-Yu, additional, Hersh, Craig P., additional, Bidinger, Jacqueline, additional, Cho, Michael H., additional, Conrad, Douglas, additional, DeMeo, Dawn L., additional, El-Boueiz, Adel R., additional, Foreman, Marilyn G., additional, Ghosh, Auyon, additional, Hahn, Georg, additional, Hansel, Nadia N., additional, Hayden, Lystra P., additional, Hobbs, Brian, additional, Kim, Woori, additional, Lange, Christoph, additional, McDonald, Merry- Lynn, additional, McGeachie, Michael, additional, Moll, Matthew, additional, Morris, Melody, additional, Patsopoulos, Nikolaos A., additional, Qiao, Dandi, additional, Ruczinski, Ingo, additional, Wan, Emily S., additional, Dy, Jennifer G., additional, Fain, Sean B., additional, Ginsburg, Shoshana, additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Judy, Philip F., additional, Stefanie Mason, Alex Kluiber, additional, Oh, Andrea, additional, Poynton, Clare, additional, Reinhardt, Joseph M., additional, Ross, James, additional, Schroeder, Joyce D., additional, Sitek, Arkadiusz, additional, Steiner, Robert M., additional, van Beek, Edwin, additional, Ginneken, Bram van, additional, van Rikxoort, Eva, additional, Jensen, Robert, additional, John E. Hokanson, Co-Chair:, additional, Bhatt, Surya P., additional, Kim, Victor, additional, Putcha, Nirupama, additional, Han, MeiLan, additional, Diaz, Alejandro A., additional, Regan, Elizabeth, additional, Anzueto, Antonio, additional, Bailey, William C., additional, Criner, Gerard J., additional, Sprenger, Kim, additional, Benos, Takis, additional, Hanania, Nicola A., additional, Hoth, Karin F., additional, Lambert, Allison, additional, Lowe, Katherine, additional, Oates, Gabriela, additional, Parekh, Trisha, additional, Westney, Gloria, additional, Balasubramanian, Aparna, additional, Boriek, Aladin, additional, Fawzy, Ashraf, additional, Jacobson, Francine, additional, LaFon, David C., additional, MacIntyre, Neil, additional, Maselli-Caceres, Diego, additional, McCormack, Meredith C., additional, Sciurba, Frank, additional, Soler, Xavier, additional, Tejwani, Vickram, additional, van Beek, Edwin JR., additional, Wade, Raymond C., additional, Wells, Mike, additional, Wendt, Chris H., additional, Yun, Jeong H., additional, Zhang, Jingzhou, additional, Gillenwater, Lucas, additional, Lowe, Katherine E., additional, Pratte, Katherine A., additional, Ragland, Margaret, additional, Attaway, Amy, additional, Mason, Stefanie, additional, Saha, Punam Kumar, additional, Wilson, Ava, additional, Amaza, Hannatu, additional, Baldomero, Adrienne, additional, Mamary, A. James, additional, O’Brien, James, additional, Wise, Robert A., additional, Eakin, Michelle, additional, Fiedorowicz, Jess G., additional, Henkle, Ben, additional, Holm, Kristen, additional, Iyer, Anand, additional, Kunisaki, Ken M., additional, McEvoy, Charlene, additional, Mkorombindo, Takudzwa, additional, Shinozaki, Gen, additional, Yohannes, Abebaw, additional, Hobbs, Brian D., additional, Miller, Bruce E., additional, Retson, Tara, additional, McCloskey, Lisa, additional, Pernicano, Perry G., additional, Atik, Mustafa, additional, Bertrand, Laura, additional, Monaco, Thomas, additional, Narendra, Dharani, additional, Lenge de Rosen, Veronica V., additional, Badu-Danso, Kwame, additional, Jacobson, Francine L., additional, Kaufman, Laura, additional, Maguire, Cherie, additional, Struble, Sophie, additional, Wilson, Seth, additional, Barr, R. Graham, additional, Almonte, Casandra, additional, Austin, John H.M., additional, Gomez Blum, Maria Lorena, additional, D’Souza, Belinda M., additional, Florez, Emilay, additional, Martinez, Rodney, additional, Curry, Wendy, additional, McAdams, H. Page, additional, Reikofski, Charlotte V., additional, Washington, Lacey, additional, Brown, Robert, additional, Clare, Cheryl, additional, Daniel, Marie, additional, Horton, Karen, additional, Ting “Tony” Lin, Cheng, additional, Mirza, Tahira, additional, Scott, Meagan, additional, Shade, Becky, additional, Budoff, Matt, additional, Calmelat, Robert, additional, Cavanaugh, Deborah, additional, Dailing, Chris, additional, Diaz, Leticia, additional, Fischer, Hans, additional, Indelicato, Renee Love, additional, Porszasz, Janos, additional, Soriano, April, additional, Stringer, William, additional, Urrutia, Miriam, additional, Baldomero, Arianne, additional, Bell, Brian, additional, Deconcini, Miranda, additional, Loes, Linda, additional, Phelan, Jonathan, additional, Robichaux, Camille, additional, Sasse, Cheryl, additional, Tashjian, Joseph H., additional, Flenaugh, Eric L., additional, Abson, Kema, additional, Gebrekristos, Hirut, additional, Johnson, Priscilla, additional, Jordan, Jessica, additional, Ponce, Mario, additional, Terpenning, Silanath, additional, Wilson, Derrick, additional, Broadhurst, Grace, additional, Dyer, Debra, additional, Engel, Elena, additional, Finigan, Jay, additional, Hill, Andrew, additional, Jones, Alex, additional, Jones, Ryan, additional, Owen, Jordan, additional, Rosiello, Richard, additional, Andries, Nicole, additional, Charpentier, Mary, additional, Kirk, Diane, additional, Pace, David, additional, Ciccolella, David, additional, Cordova, Francis, additional, Dass, Chandra, additional, D’Alonzo, Gilbert, additional, Davis, Valena, additional, Desai, Parag, additional, Fehrle, Dee, additional, Grabianowski, Carla, additional, Jacobs, Michael, additional, Jameson, Laurie, additional, Jones, Gayle M., additional, Kelsen, Steven, additional, Marchetti, Nathaniel, additional, McGonagle, Francine, additional, Satti, Aditi, additional, Shenoy, Kartik, additional, Sheridan, Regina, additional, Vega-Sanchez, Maria, additional, Wallace, Samantha, additional, Akinseye-kolapo, Samuel, additional, Baker, Matthew, additional, Goggins, Arnissa, additional, McClain, Anny, additional, Nath, Hrudaya, additional, Singh, Satinder P., additional, Sonavane, Sushil K., additional, Westfall, Elizabeth, additional, Gil, Marissa, additional, El Hajjaoui, Tarek, additional, Hsiao, Albert, additional, Martineau, Amber, additional, Mielke, Jenna, additional, Perez, Karl, additional, Querido, Gabriel, additional, Reston, Tara, additional, Yen, Andrew, additional, Comellas, Alejandro, additional, Fortis, Spyridon, additional, Galizia, Mauricio, additional, Garcia, Eric, additional, Keating, Janet, additional, Laroia, Archana, additional, Lee, Changhyun, additional, Meyer, Amber, additional, Mullan, Brian, additional, Nagpal, Prashant, additional, Ofori, Oloigbe, additional, and Suiter, Sierra, additional
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- 2022
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88. Beyond the AJR: Potential of Deep Learning Image Classification for Chest Radiography
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Hsiao, Albert, primary
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- 2022
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89. Deep Learning Radiographic Assessment of Pulmonary Edema: Training with Serum Biomarkers
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Huynh, Justin, primary, Masoudi, Samira, additional, Noorbakhsh, Abraham, additional, Mahmoodi, Amin, additional, Kligerman, Seth, additional, Yen, Andrew, additional, Jacobs, Kathleen, additional, Hahn, Lewis, additional, Hasenstab, Kyle, additional, Pazzani, Michael, additional, and Hsiao, Albert, additional
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- 2022
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90. Erratum: CNN-based Deformable Registration Facilitates Fast and Accurate Air Trapping Measurements at Inspiratory and Expiratory CT
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Hasenstab, Kyle A., primary, Tabalon, Joseph, additional, Yuan, Nancy, additional, Retson, Tara, additional, and Hsiao, Albert, additional
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- 2022
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91. Contributors
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Ahmed, S. Uzair, Albuquerque, Felipe C., Amar, Arun Paul, Amllay, Abdelaziz, Antonios, Joseph P., Apuzzo, Michael L.J., Atalay, Yahya B., Ayub, Muhammad Abubakar, Aziz-Sultan, Mohammad A., Barros, Guilherme, Barrow, Daniel L., Bernardo, Antonio, Boddu, Srikanth, Bolar, Divya S., Caplan, Justin M., Carnevale, Joseph A., Carroll, Kate T., Catapano, Joshua S., Chen, Ching-Jen, Sander Connolly, E., Jr., David, Carlos A., Desai, Milli J., Dodd, William, Dornbos, David, III, Dowd, Richard S., Faramand, Andrew, Fejleh, Ashley, Flickinger, John C., Fraser, Justin F., Friedlander, Robert M., Garton, Andrew L.A., Ghannam, Moleca, Giantini-Larsen, Alexandra M., Goldberg, Jacob L., Goutnik, Michael, Gross, Bradley A., Hardigan, Trevor, Hoh, Brian L., Howard, Brian M., Hsiao, Albert, Huang, Judy, Jackson, Christopher M., Kano, Hideyuki, Karanjia, Navaz, Khalessi, Alexander A., Kim, Jennifer E., Kim, Louis J., Knopman, Jared, Kocharian, Gary, Lai, Pui Man Rosalind, Lam, Arthur M., Lamorie-Foote, Krista, Lang, Michael J., Laurent, Dimitri, Lawton, Michael T., Lee, Hubert, Lemkuil, Brian P., Levy, Elad I., Lucke-Wold, Brandon, Lunsford, L. Dade, Mack, William, Matouk, Charles C., McCarthy, David J., Meyer, R. Michael, Mocco, J, Mouchtouris, Nikolaos, Murthy, Santosh B., Niranjan, Ajay, Nistal, Dominic A., Norbash, Alexander, Ogilvy, Christopher S., Oh, S. Paul, Pannell, J. Scott, Patel, Aman B., Rahmani, Redi, Ramos, Alexander D., Regenhardt, Robert W., Renedo, Daniela, Rosenwasser, Robert H., Roytman, Michelle, Russin, Jonathan, Salem, Mohamed M., Scherschinski, Lea, Schwarz, Justin, Sekhar, Laligam N., Sen, Rajeev D., Sheehan, Jason P., Shenoy, Varadaraya S., Siddiqui, Adnan H., Sizdahkhani, Saman, Small, Coulter Nathan, Soman, Salil, Souweidane, Mark M., Spinazzi, Eleonora F., Srinivas, Shanmukha, Srinivasan, Visish M., Steinberg, Gary K., Stieg, Philip E., Sujijantarat, Nanthiya, Sweid, Ahmad, Tahir, Rizwan, Tamargo, Rafael J., Tjoumakaris, Stavropoula, Tsiouris, Apostolos John, Vranic, Justin E., Wali, Arvin R., Waqas, Muhammad, White, Halina, Xu, Risheng, Yachnis, Anthony T., Yaeger, Kurt, Yun, Jonathan J., and Zetchi, Akli
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- 2024
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92. Hemodynamic Assessment of Structural Heart Disease Using 4D Flow MRI: How We Do It
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Jacobs, Kathleen, primary, Hahn, Lewis, additional, Horowitz, Michael, additional, Kligerman, Seth, additional, Vasanawala, Shreyas, additional, and Hsiao, Albert, additional
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- 2021
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93. Prevalence of Venovenous Shunting and High-Output State Quantified with 4D Flow MRI in Patients with Fontan Circulation
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Raimondi, Francesca, primary, Martins, Duarte, additional, Coenen, Raluca, additional, Panaioli, Elena, additional, Khraiche, Diala, additional, Boddaert, Nathalie, additional, Bonnet, Damien, additional, Atkins, Melany, additional, El-Said, Howaida, additional, Alshawabkeh, Laith, additional, and Hsiao, Albert, additional
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- 2021
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94. Radiologist-supervised Transfer Learning
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Hurt, Brian, primary, Rubel, Meagan A., additional, Masutani, Evan M., additional, Jacobs, Kathleen, additional, Hahn, Lewis, additional, Horowitz, Michael, additional, Kligerman, Seth, additional, and Hsiao, Albert, additional
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- 2021
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95. Global left ventricular function quantification with CMR 4D Flow
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Saru, Raluca G, Wanambiro, Kevin, Hsiao, Albert, Boccalini, Sara, Coenen, Adriaan, Budde, Ricardo, Wielopolski, Piotr, Vasanawala, Shreyas, Roos-Hesselink, Jolien, and Nieman, Koen
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- 2016
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96. High-throughput Biology in the Postgenomic Era
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Hsiao, Albert and Kuo, Michael D.
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- 2009
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97. Aortic coarctation and interrupted aortic arch
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Hsiao, Albert, primary and Newman, Beverley, additional
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- 2014
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98. Advancing Cardiovascular MRI Acquisition Through Deep Convolutional Neural Network-Based Localization
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Blansit, Kevin, Hsiao, Albert AH1, Blansit, Kevin, Blansit, Kevin, Hsiao, Albert AH1, and Blansit, Kevin
- Abstract
Cardiac MRI is the gold standard for quantification of cardiac volumetry, function, and blood flow. Despite the wealth of information that may be gleamed from these acquisitions, its use has been limited primarily to academic and specialty clinics due to the need for specialty trained physicians and technologists required for planning of these scans.Recently, deep convolutional neural networks (DCNNs) have shown promise in automating various aspects of radiological workflows, such as landmark localization. However, a primary limitation to applying DCNNs to clinical practice include uncertainty of how well an algorithm will perform outside of the environment in which it was trained. Moreover, these systems are often seen as “black boxes”, which fail to provide an explanation of how an answer was achieved. Providing a way in which clinical end users may have confidence in these systems is therefore essential for clinical adoption of any medically focused DCNN system.With these concerns in mind, I explore the potential automating the planning of Cardiac MR imaging planes using DCNN. In the first chapter, I explore the potential of automating the prescription of long-axis and short axis imaging planes by localizing the landmarks. To preserve the iterability in the DCNN, I regress pseudoprobability heatmaps (termed heatmap regression) centered at the valve and apex landmarks. I demonstrate that this approach of heatmap regression not only accurately identifies the landmarks, it is additionally able to recreate imaging planes similar to those defined by the ground truth landmarks or those acquired by a technologist at the time of original acquisition.In my second chapter, I explore the potential to applying these DCNNs within a clinical setting. I first established the importance of our angulation metric for assessing the accuracy imaging plane. To assess the generalizability of this system to different clinical environments, I calculated the angulation error between grou
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- 2021
99. Improved cardiovascular flow quantification with time-resolved volumetric phase-contrast MRI
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Hsiao, Albert, Alley, Marcus T., Massaband, Payam, Herfkens, Robert J., Chan, Frandics P., and Vasanawala, Shreyas S.
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- 2011
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100. Improved visualization and quantification of 4D flow data using divergence-free wavelets
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Ong Frank, Uecker Martin, Tariq Umar, Hsiao Albert, Vasanawala Shreyas S, and Lustig Michael
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2013
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