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RESEARCH QUESTION Can a reliable measure of precise harm levels for the 100 most harmful and frequently occurring offences be developed in Western Australia (WA) based on analysis of actual court penalties for first-time offenders? DATA Criminal and traffic court sentences in 2.2 million records over 6.5 years were analysed to extract the number of days of imprisonment actually imposed in sentencing decisions for approximately 52,000 first-time offenders (see House 2017). METHODS Sentences for all first offenders in a sample of the 102 most common offence categories were analysed to compute for the median number of days of imprisonment to which each first offender was sentenced in each of the categories. Monetary penalties and conditional community sentences were converted to equivalent ‘prison days’ and added to the computation of the median of days of imprisonment per offence category. The number of reported offences in WA in the study period for each of the 102 categories was then multiplied by the median prison days sentenced per category. The sum of the products of median prison days times offence count was then tallied across all offence categories to form a weighted index of crime harm, which we define as the Western Australian Crime Harm Index (WACHI). Applying a minimum requirement of at least five separate court cases for each crime category, a total of 88 offence categories survived the reliability threshold for inclusion in the index. FINDINGS The 88 offence categories in the WACHI contain both high-harm and highvolume offences, permitting 95% of all offences reported for over 5 years to be assessed for WACHI scores. The counts for these offences moved in different directions from the WACHI total in two of the four year-to-year comparisons. Changes in WACHI were shown to have been highly sensitive to increased reporting of historical sex crimes, isolated in one district each of both Metropolitan Perth and one Regional centre. CONCLUSIONS Carefully implemented use of the West Australian CHI could improve both public safety and policing by adding precision to resource allocation decisions, assessments of priorities and evaluations of policing initiatives. The WACHI would be even more reflective of the changing level of harm to victims if all crime trends were to be based on crimes that occurred in the year under analysis, with separate reporting of crimes that happened many years ago. With that key adjustment, police professionals, department of justice officials, citizens and local governments can use a WACHI to make better decisions about how to prioritise policing in a wide range of contexts.

Factor-Xa inhibitors like edoxaban have been shown to have comparable or superior rates of stroke and systemic embolization prevention to warfarin while exhibiting lower clinically significant bleeding rates. The authors report a case of a man who presented with delayed, recurrent intracranial hemorrhage months after successful deep brain stimulator placement for Parkinson disease while on edoxaban for atrial fibrillation. Further reports on the use of novel anticoagulants after intracranial surgery are acutely needed to help assess the true relative risk they pose.

BACKGROUND AND PURPOSE: The brain perivascular spaces (PVSs) are pial-lined, interstitial fluid-filled structures that accompany penetrating arteries. When enlarged, they may cause mass effect and can be mistaken for more ominous pathologic processes. The purpose of this study was to delineate the broad clinical and imaging spectrum of this unusual condition. METHODS: Thirty-seven cases of giant PVSs were identified from 1988 to 2004 and were retrospectively reviewed. Clinical data collected included patient demographics, presenting symptoms, and follow-up. Histopathologic data were reviewed when available. Images were evaluated for size and location of the giant PVSs, associated mass effect, hydrocephalus, adjacent white matter changes, and contrast enhancement. RESULTS: There were 24 men and 13 women with an age range of 6–86 years, (mean 46 years). The most common presenting feature was headache (15 patients). Thirty-two cases had multilocular clusters of variably sized cysts. Five lesions were unilocular. All lesions had signal intensity comparable to CSF and did not enhance. The most common location for the giant PVSs was the mesencephalothalamic region (21/36). Fourteen were located in the cerebral white matter; two were in the dentate nuclei. Nine giant mesencephalothalamic PVSs had associated hydrocephalus, which required surgical intervention. CONCLUSION: Giant tumefactive PVSs most often appear as clusters of variably sized cysts that are isointense relative to CSF and do not enhance. They are most common in the mesencephalothalamic region and may cause hydrocephalus. Although they may have striking mass effect, giant PVSs should not be mistaken for neoplasm or other diseases.

Ofrece los contenidos del currículo oficial de biología y geología del cuarto curso de la ESO en inglés. El propósito principal de este manual del profesor, es proporcionar apoyo en las aulas, desde un punto de vista científico y claro. El material que ha sido desarrollado desde una perspectiva científica, facilita la integración de los conocimientos y fomenta el desarrollo del razonamiento. Permite cumplir los objetivos curriculares tanto en España como en el Reino Unido. SC Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel. +34917748000; biblioteca@mecd.es ESP

Ofrece los contenidos del currículo oficial de biología y geología de tercero de la ESO en inglés. El propósito principal de este manual del profesor, es proporcionar apoyo en las aulas, desde un punto de vista científico y claro. El material que ha sido desarrollado desde una perspectiva científica, facilita la integración de los conocimientos y fomenta el desarrollo del razonamiento. Permite cumplir los objetivos curriculares tanto en España como en el Reino Unido. SC Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 planta; 28014 Madrid; Tel. +34917748000; biblioteca@mecd.es ESP