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52. Challenges of controlling a large outbreak of OXA-48 carbapenemase-producing Klebsiella pneumoniae in a French university hospital

Author

Semin-Pelletier, B., primary, Cazet, L., additional, Bourigault, C., additional, Juvin, M.E., additional, Boutoille, D., additional, Raffi, F., additional, Hourmant, M., additional, Blancho, G., additional, Agard, C., additional, Connault, J., additional, Corvec, S., additional, Caillon, J., additional, Batard, E., additional, and Lepelletier, D., additional

Published
2015
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54. Difficulté de maîtrise de la diffusion épidémique d’entérobactéries productrices de carbapénèmases (EPC) OXA48 dans un service de néphrologie français

Author

Pouteau, L.M., primary, Touzot, M., additional, Vercel-Gourraud, C., additional, Couvrat-Desvergnes, G., additional, Le Fur, A., additional, Picard, M., additional, Chapal, M., additional, Bourigault, C., additional, Jallu, C., additional, Lepelletier, D., additional, and Hourmant, M., additional

Published
2014
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57. Caractéristiques démographiques et médicales des patients (pts) incidents pris en hémodialyse (HD) entre 2007–2012. Expérience du Centre de néphrologie-dialyse du Pôle Santé Sud du Mans. Comment optimiser la prise en charge en HD des octogénaires ?

Author

Laradi, A., primary, Cremault, A., additional, Babinet, F., additional, Lanoiselee, S., additional, Hureau, C., additional, Hourmant, M., additional, Hami, A., additional, Couchoud, C., additional, and Menoyo, V., additional

Published
2014
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58. Aspects cliniques et génétiques de la polykystose rénale autosomique dominante (PKAD) liée à une mutation du gène PKD2 : résultats de la cohorte Genkyst

Author

Cornec-Le Gall, E., primary, Renaudineau, E., additional, Kersalé, A., additional, Hourmant, M., additional, Morin, M.P., additional, Jousset, P., additional, Wehbe, B., additional, Charasse, C., additional, Michez, E., additional, Férec, C., additional, Audrézet, M.P., additional, and Le Meur, Y., additional

Published
2014
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60. SFP PC-73 – Données clinico-biologiques des patients homozygotes et hétérozygotes mutés pour CYP24A1

Author

Figueres, M., primary, Allain-Launay, E., additional, Roussey-Kesler, G., additional, Bienaimé, F., additional, Linglart, A., additional, Isidor, B., additional, Knebelman, B., additional, Kury, S., additional, Lambert, A., additional, Nathanson, S., additional, Prier, D., additional, Ryckwaert, A., additional, Souberbielle, J., additional, Kottler, M., additional, and Hourmant, M., additional

Published
2014
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61. Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome.

Author

Legendre, C.M., Licht, C., Muus, P., Greenbaum, L.A., Babu, S., Bedrosian, C., Bingham, C., Cohen, D.J., Delmas, Y., Douglas, K., Eitner, F., Feldkamp, T., Fouque, D., Furman, R.R., Gaber, O., Herthelius, M., Hourmant, M., Karpman, D., Lebranchu, Y., Mariat, C., Menne, J., Moulin, B., Nurnberger, J., Ogawa, M., Remuzzi, G., Richard, T., Sberro-Soussan, R., Severino, B., Sheerin, N.S., Trivelli, A., Zimmerhackl, L.B., Goodship, T., Loirat, C., Legendre, C.M., Licht, C., Muus, P., Greenbaum, L.A., Babu, S., Bedrosian, C., Bingham, C., Cohen, D.J., Delmas, Y., Douglas, K., Eitner, F., Feldkamp, T., Fouque, D., Furman, R.R., Gaber, O., Herthelius, M., Hourmant, M., Karpman, D., Lebranchu, Y., Mariat, C., Menne, J., Moulin, B., Nurnberger, J., Ogawa, M., Remuzzi, G., Richard, T., Sberro-Soussan, R., Severino, B., Sheerin, N.S., Trivelli, A., Zimmerhackl, L.B., Goodship, T., and Loirat, C.

Abstract

Item does not contain fulltext, BACKGROUND: Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic microangiopathy. Plasma exchange or infusion may transiently maintain normal levels of hematologic measures but does not treat the underlying systemic disease. METHODS: We conducted two prospective phase 2 trials in which patients with atypical hemolytic-uremic syndrome who were 12 years of age or older received eculizumab for 26 weeks and during long-term extension phases. Patients with low platelet counts and renal damage (in trial 1) and those with renal damage but no decrease in the platelet count of more than 25% for at least 8 weeks during plasma exchange or infusion (in trial 2) were recruited. The primary end points included a change in the platelet count (in trial 1) and thrombotic microangiopathy event-free status (no decrease in the platelet count of >25%, no plasma exchange or infusion, and no initiation of dialysis) (in trial 2). RESULTS: A total of 37 patients (17 in trial 1 and 20 in trial 2) received eculizumab for a median of 64 and 62 weeks, respectively. Eculizumab resulted in increases in the platelet count; in trial 1, the mean increase in the count from baseline to week 26 was 73x10(9) per liter (P<0.001). In trial 2, 80% of the patients had thrombotic microangiopathy event-free status. Eculizumab was associated with significant improvement in all secondary end points, with continuous, time-dependent increases in the estimated glomerular filtration rate (GFR). In trial 1, dialysis was discontinued in 4 of 5 patients. Earlier intervention with eculizumab was associated with significantly greater improvement in the estimated GFR. Eculizumab was also associated with improvement in health-related quality of life. No cumulative toxicity of therapy or serious infection-related adverse events, including meningococcal infections, were observed through the extension period. CONCLUSIONS: Eculizumab inhibited complement-mediated

Published
2013

62. What is the value of procurement biopsy lipid peroxidation lesions in the assessment of kidney graft function?

Author

M.N Peraldi, C. Hiesse, Valérie Paradis, Bernard Charpentier, Gérard Benoit, Hourmant M, Pascal Eschwege, Pierre Bedossa, M Amor, Bedrossian J, Kessler M, P.H Lang, L Joseph, Stéphane Droupy, J Robert, E Rondeau, and C. Antoine

Subjects
Pathology, medicine.medical_specialty, Arteriosclerosis, Biopsy, Kidney, Renal Artery Obstruction, Graft function, Lesion, Lipid peroxidation, chemistry.chemical_compound, Malondialdehyde, medicine, Cadaver, Humans, Transplantation, Aldehydes, medicine.diagnostic_test, business.industry, Glomerulosclerosis, Focal Segmental, Predictive value, Tissue Donors, medicine.anatomical_structure, chemistry, Tissue and Organ Harvesting, Surgery, Histopathology, Lipid Peroxidation, medicine.symptom, business, Biomarkers
Published
2001

65. Peut-on prédire l’âge de survenue de l’insuffisance rénale terminale dans la polykystose rénale autosomique dominante ? Construction d’un nouveau modèle pronostique

Author

Cornec-Le Gall, E., primary, Hourmant, M., additional, Morin, M.P., additional, Charasse, C., additional, Perrichot, R., additional, Renaudineau, E., additional, Treguer, L., additional, Whebe, B., additional, Jousset, P., additional, Audrezet, M.P., additional, Ferec, C., additional, and Le Meur, Y., additional

Published
2013
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68. Genetic diseases and molecular genetics

Author

Legendre, C., primary, Cohen, D., additional, Delmas, Y., additional, Feldkamp, T., additional, Fouque, D., additional, Furman, R., additional, Gaber, O., additional, Greenbaum, L., additional, Goodship, T., additional, Haller, H., additional, Herthelius, M., additional, Hourmant, M., additional, Licht, C., additional, Moulin, B., additional, Sheerin, N., additional, Trivelli, A., additional, Bedrosian, C. L., additional, Loirat, C., additional, Legendre, C., additional, Babu, S., additional, Jungraithmayr, T., additional, Lebranchu, Y., additional, Riedl, M., additional, Gaber, A. O., additional, Bedrosian, C., additional, Muus, P., additional, Douglas, K., additional, Remuzzi, G., additional, Kourouklaris, A., additional, Ioannou, K., additional, Athanasiou, I., additional, Demetriou, K., additional, Panagidou, A., additional, Zavros, M., additional, Rodriguez C, N. Y., additional, Blasco, M., additional, Arcal, C., additional, Quintana, L. F., additional, Rodriguez de Cordoba, S., additional, Campistol, J. M., additional, Bachmann, N., additional, Eisenberger, T., additional, Decker, C., additional, Bolz, H. J., additional, Bergmann, C., additional, Pesce, F., additional, Cox, S. N., additional, Serino, G., additional, De Palma, G., additional, Sallustio, F. P., additional, Schena, F., additional, Falchi, M., additional, Pieri, M., additional, Stefanou, C., additional, Zaravinos, A., additional, Erguler, K., additional, Lapathitis, G., additional, Dweep, H., additional, Sticht, C., additional, Anastasiadou, N., additional, Zouvani, I., additional, Voskarides, K., additional, Gretz, N., additional, Deltas, C. C., additional, Ruiz, A., additional, Bonny, O., additional, Sallustio, F., additional, Curci, C., additional, Cox, S., additional, Kemter, E., additional, Sklenak, S., additional, Aigner, B., additional, Wanke, R., additional, Kitzler, T. M., additional, Moskowitz, J. L., additional, Piret, S. E., additional, Lhotta, K., additional, Tashman, A., additional, Velez, E., additional, Thakker, R. V., additional, Kotanko, P., additional, Leierer, J., additional, Rudnicki, M., additional, Perco, P., additional, Koppelstaetter, C., additional, Mayer, G., additional, Sa, M. J. N., additional, Alves, S., additional, Storey, H., additional, Flinter, F., additional, Willems, P. J., additional, Carvalho, F., additional, Oliveira, J., additional, Arsali, M., additional, Papazachariou, L., additional, Demosthenous, P., additional, Lazarou, A., additional, Hadjigavriel, M., additional, Stavrou, C., additional, Yioukkas, L., additional, Deltas, C., additional, Pierides, A., additional, Kkolou, M., additional, Toka, H. R., additional, Dibartolo, S., additional, Lanske, B., additional, Brown, E. M., additional, Pollak, M. R., additional, Familiari, A., additional, Zavan, B., additional, Sanna Cherchi, S., additional, Fabris, A., additional, Cristofaro, R., additional, Gambaro, G., additional, D'Angelo, A., additional, Anglani, F., additional, Toka, H., additional, Mount, D., additional, Pollak, M., additional, Curhan, G., additional, Sengoge, G., additional, Bajari, T., additional, Kupczok, A., additional, von Haeseler, A., additional, Schuster, M., additional, Pfaller, W., additional, Jennings, P., additional, Weltermann, A., additional, Blake, S., additional, Sunder-Plassmann, G., additional, Kerti, A., additional, Csohany, R., additional, Wagner, L., additional, Javorszky, E., additional, Maka, E., additional, Tulassay, T., additional, Tory, K., additional, Kingswood, J., additional, Nikolskaya, N., additional, Mbundi, J., additional, Jozwiak, S., additional, Belousova, E., additional, Frost, M., additional, Kuperman, R., additional, Bebin, M., additional, Korf, B., additional, Flamini, R., additional, Kohrman, M., additional, Sparagana, S., additional, Wu, J., additional, Brechenmacher, T., additional, Stein, K., additional, Bissler, J., additional, Franz, D., additional, Zonnenberg, B., additional, Cheung, W., additional, Wang, J., additional, Lam, D., additional, Budde, K., additional, Ivanitskiy, L., additional, Sowershaewa, E., additional, Krasnova, T., additional, Samokhodskaya, L., additional, Safarikova, M., additional, Jana, R., additional, Jitka, S., additional, Obeidova, L., additional, Kohoutova, M., additional, Tesar, V., additional, Evrengul, H., additional, Ertan, P., additional, Serdaroglu, E., additional, Yuksel, S., additional, Mir, S., additional, Yang n Ergon, E., additional, Berdeli, A., additional, Zawada, A., additional, Rogacev, K., additional, Rotter, B., additional, Winter, P., additional, Fliser, D., additional, Heine, G., additional, Bataille, S., additional, Moal, V., additional, Berland, Y., additional, Daniel, L., additional, Rosado, C., additional, Bueno, E., additional, Fraile, P., additional, Lucas, C., additional, Garcoa-Cosmes, P., additional, Tabernero, J. M., additional, Gonzalez, R., additional, Garcia-Cosmes, P., additional, Silska-Dittmar, M., additional, Zaorska, K., additional, Malke, A., additional, Musielak, A., additional, Ostalska-Nowicka, D., additional, Zachwieja, J., additional, K d r, V., additional, Uz, E., additional, Yigit, A., additional, Altuntas, A., additional, Yigit, B., additional, Inal, S., additional, Sezer, M., additional, Yilmaz, R., additional, Visciano, B., additional, Porto, C., additional, Acampora, E., additional, Russo, R., additional, Riccio, E., additional, Capuano, I., additional, Parenti, G., additional, Pisani, A., additional, Feriozzi, S., additional, Perrin, A., additional, West, M., additional, Nicholls, K., additional, Torras, J., additional, Cybulla, M., additional, Conti, M., additional, Angioi, A., additional, Floris, M., additional, Melis, P., additional, Asunis, A. M., additional, Piras, D., additional, Pani, A., additional, Warnock, D., additional, Guasch, A., additional, Thomas, C., additional, Wanner, C., additional, Campbell, R., additional, Vujkovac, B., additional, Okur, I., additional, Biberoglu, G., additional, Ezgu, F., additional, Tumer, L., additional, Hasanoglu, A., additional, Bicik, Z., additional, Akin, Y., additional, Mumcuoglu, M., additional, Ecder, T., additional, Paliouras, C., additional, Mattas, G., additional, Papagiannis, N., additional, Ntetskas, G., additional, Lamprianou, F., additional, Karvouniaris, N., additional, and Alivanis, P., additional

Published
2013
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69. Transplantation: clinical studies - A

Author

Yildirim, T., primary, Yilmaz, R., additional, Altindal, M., additional, Turkmen, E., additional, Arici, M., additional, Altun, B., additional, Erdem, Y., additional, Guliyev, O., additional, Erkmen Uyar, M., additional, Tutal, E., additional, Bal, Z., additional, Sezer, S., additional, Bal, U., additional, Say n, B., additional, Erdemir, B., additional, O'Rourke-Potowki, A., additional, Gauge, N., additional, Penny, H., additional, Cronin, A., additional, Frame, S., additional, Goldsmith, D. J., additional, Yagan, J. A., additional, Chandraker, A., additional, Velickovic Radovanovic, R. M., additional, Catic Djordjevic, A., additional, Mitic, B., additional, Stefanovic, N., additional, Cvetkovic, T., additional, Serpieri, N., additional, Grosjean, F., additional, Sileno, G., additional, Torreggiani, M., additional, Esposito, V., additional, Mangione, F., additional, Abelli, M., additional, Castoldi, F., additional, Catucci, D., additional, Esposito, C., additional, Dal Canton, A., additional, Vatazin, A. V., additional, Zulkarnaev, A. B., additional, Borst, C., additional, Liu, Y., additional, Thoning, J., additional, Tepel, M., additional, Libetta, C., additional, Margiotta, E., additional, Borettaz, I., additional, Canevari, M., additional, Martinelli, C., additional, Lainu, E., additional, Meloni, F., additional, Sepe, V., additional, Miguel Costa, R., additional, Vasquez Martul, E., additional, Reboredo, J., additional, Rivera, C., additional, Simonato, F., additional, Tognarelli, G., additional, Daidola, G., additional, Gallo, E., additional, Burdese, M., additional, Cantaluppi, V., additional, Biancone, L., additional, Segoloni, G. P., additional, Priora, M., additional, Messina, M., additional, Tamagnone, M., additional, Linsalata, A., additional, Lavacca, A., additional, Segoloni, G., additional, Zuidema, W., additional, Erdman, R., additional, van de Wetering, J., additional, Dor, F., additional, Roodnat, J., additional, Massey, E., additional, Timmerman, L., additional, IJzermans, J., additional, Weimar, W., additional, Sibley-Allen, C., additional, Hilton, R., additional, Moghul, M., additional, Burnapp, L., additional, Blake, G., additional, Koo, T. Y., additional, Park, J.-S., additional, Park, H. C., additional, Kim, G.-H., additional, Lee, C. H., additional, Oh, I. H., additional, Kang, C. M., additional, Hwang, J. K., additional, Park, S. C., additional, Choi, B. S., additional, Chun, H. J., additional, Kim, J. I., additional, Yang, C. W., additional, Moon, I. S., additional, Van Laecke, S., additional, Van Biesen, W., additional, Nagler, E. V., additional, Taes, Y., additional, Peeters, P., additional, Vanholder, R., additional, Pruthi, R., additional, Ravanan, R., additional, Casula, A., additional, Harber, M., additional, Roderick, P., additional, Fogarty, D., additional, Cho, A., additional, Shin, J.-h., additional, Jang, H. R., additional, Lee, J. E., additional, Huh, W., additional, Kim, D. J. K., additional, Oh, H. Y., additional, Kim, Y.-G., additional, Sancho Calabuig, A., additional, Gavela Martinez, E., additional, Kanter Berga, J., additional, Beltran Catalan, S., additional, Avila Bernabeu, A. I., additional, Pallardo Mateu, L. M., additional, Gonzalez, E., additional, Polanco, N., additional, Molina, M., additional, Gutierrez, E., additional, Garcia Puente, L., additional, Sevillano, A., additional, Morales, E., additional, Praga, M., additional, Andres, A., additional, Banasik, M., additional, Boratynska, M., additional, Koscielska-Kasprzak, K., additional, Bartoszek, D., additional, Myszka, M., additional, Zmonarski, S., additional, Nowakowska, B., additional, Wawrzyniak, E., additional, Halon, A., additional, Chudoba, P., additional, Klinger, M., additional, Rojas-Rivera, J., additional, Morales, J. M., additional, Egido, J., additional, Kopecky, C. M., additional, Haidinger, M., additional, Kaltenecker, C., additional, Antlanger, M., additional, Marsche, G., additional, Holzer, M., additional, Kovarik, J., additional, Werzowa, J., additional, Hecking, M., additional, Saemann, M. D., additional, Kim, J. M., additional, Koh, E. S., additional, Chung, B. H., additional, Kim, Y. S., additional, Krajewska, M., additional, Mazanowska, O., additional, Kaminska, D., additional, Zabinska, M., additional, Malkiewicz, B., additional, Patrzalek, D., additional, Sulowicz, J., additional, Szostek, S., additional, Wojas-Pelc, A., additional, Ignacak, E., additional, Sulowicz, W., additional, Bellizzi, V., additional, Calella, P., additional, Cupisti, A., additional, Capitanini, A., additional, D'Alessandro, C., additional, Giannese, D., additional, Camocardi, A., additional, Conte, G., additional, Barsotti, M., additional, Bilancio, G., additional, Luciani, R., additional, Locsey, L., additional, Seres, I., additional, Kovacs, D., additional, Asztalos, L., additional, Paragh, G., additional, Wohlfahrtova, M., additional, Balaz, P., additional, Rokosny, S., additional, Wohlfahrt, P., additional, Bartonova, A., additional, Viklicky, O., additional, Kers, J., additional, Geskus, R. B., additional, Meijer, L. J., additional, Bemelman, F., additional, ten Berge, I. J. M., additional, Florquin, S., additional, Hwang, J.-C., additional, Jiang, M.-Y., additional, Lu, Y.-H., additional, Weng, S.-F., additional, Testa, A., additional, Porto, G., additional, Sanguedolce, M., additional, Spoto, B., additional, Parlongo, R., additional, Pisano, A., additional, Enia, G., additional, Tripepi, G., additional, Zoccali, C., additional, Mamode, N., additional, Lennerling, A., additional, Citterio, F., additional, Van Assche, K., additional, Sterckx, S., additional, Frunza, M., additional, Jung, H., additional, Pascalev, A., additional, Johnson, R., additional, Loven, C., additional, Soleymanian, T., additional, Keyvani, H., additional, Jazayeri, S. M., additional, Fazeli, Z., additional, Ghamari, S., additional, Mahabadi, M., additional, Chegeni, V., additional, Najafi, I., additional, Ganji, M. R., additional, Meys, K. M. E., additional, Groothoff, J. W., additional, Jager, K., additional, Schaefer, F., additional, Tonshoff, B., additional, Mota, C., additional, Cransberg, K., additional, van Stralen, K., additional, Gurluler, E., additional, Gures, N., additional, Alim, A., additional, Gurkan, A., additional, Cakir, U., additional, Berber, I., additional, Caluwe, R., additional, Nagler, E., additional, Van Vlem, B., additional, Betkowska-Prokop, A., additional, Kuzniewski, M., additional, Krzanowski, M., additional, Masson, I., additional, Flamant, M., additional, Maillard, N., additional, Cavalier, E., additional, Moranne, O., additional, Alamartine, E., additional, Mariat, C., additional, Delanaye, P., additional, Canas Sole, L. L., additional, Iglesias Alvarez, E., additional, Pastor, M. C. M. C., additional, Moreno Flores, F. F., additional, Abujder, V. V., additional, Graterol, F. F., additional, Bonet Sol, J. J., additional, Lauzurica Valdemoros, R. R., additional, Yoshikawa, M., additional, Kitamura, K., additional, Nakai, K., additional, Goto, S., additional, Fujii, H., additional, Ishimura, T., additional, Takeda, M., additional, Fujisawa, M., additional, Nishi, S., additional, Prasad, N., additional, Gurjer, D., additional, Bhadauria, D., additional, Gupta, A., additional, Sharma, R., additional, Kaul, A., additional, Cybulla, M., additional, West, M., additional, Nicholls, K., additional, Torras, J., additional, Sunder-Plassmann, G., additional, Feriozzi, S., additional, Lo, S., additional, Wong, P. Y. H., additional, Ip, D., additional, Wong, C. K., additional, Chow, V. C. C., additional, Mo, S. K. L., additional, Molnar, M., additional, Ujszaszi, A., additional, Czira, M. E., additional, Novak, M., additional, Mucsi, I., additional, Cruzado, J. M., additional, Coelho, S., additional, Porta, N., additional, Bestard, O., additional, Melilli, E., additional, Taco, O., additional, Rivas, I., additional, Grinyo, J., additional, Pouteau, L.-M., additional, N'Guyen, J.-M., additional, Hami, A., additional, Hourmant, M., additional, Ghahramani, N., additional, Karparvar, Z., additional, Shadrou, S., additional, Ghahramani, M., additional, Fauvel, J. P., additional, Hadj-Aissa, A., additional, Buron, F., additional, Morelon, E., additional, Ducher, M., additional, Heine, C., additional, Glander, P., additional, Neumayer, H.-H., additional, Budde, K., additional, Liefeldt, L., additional, Montero, N., additional, Webster, A. C., additional, Royuela, A., additional, Zamora, J., additional, Crespo, M., additional, Pascual, J., additional, Adema, A. Y., additional, van Dorp, W. T. H., additional, Mallat, M. J. K., additional, de Fijter, H. W., additional, Hong, Y. A., additional, Park, C. W., additional, Kim, Y.-S., additional, Suleymanlar, G., additional, Uzundurukan, Z., additional, Kapuagas , A., additional, Sencan, I., additional, Akdag, R., additional, Torio, A., additional, Mas, V., additional, Perez-Saez, M. J., additional, Mir, M., additional, Faura, A., additional, Montes-Ares, O., additional, Checa, M. D., additional, Sawinski, D., additional, Trofe-Clark, J., additional, Sparkes, T., additional, Patel, P., additional, Goral, S., additional, Bloom, R., additional, Kim, H. J., additional, Park, S. J., additional, Kim, T. H., additional, Kim, Y. W., additional, Kim, Y. H., additional, Kang, S. W., additional, Abdel Halim, M., additional, Gheith, O., additional, Al-Otaibi, T., additional, Mosaad, A., additional, Awadeen, W., additional, Said, T., additional, Nair, P., additional, and Nampoory, M. R. N., additional

Published
2013
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71. A dose-searching trial of an anti-LFA1 monoclonal antibody in first kidney transplant recipients

Author

Le Mauff B, Yannick Le Meur, Hourmant M, Debray M, Boeffard F, Alberici G, Jp, Soulillou, and Jm, Scherrmann

Subjects
Adult, Graft Rejection, Male, Adolescent, Dose-Response Relationship, Drug, Antibodies, Monoclonal, Humans, Female, Pilot Projects, Middle Aged, Kidney Transplantation, Lymphocyte Function-Associated Antigen-1
Abstract

25.3, a mouse IgG1 monoclonal antibody (MoAb), directed at the alpha chain of the LFA1 molecule (CD11a) has been used in prophylaxis of rejection in recipients of cadaveric kidney graft. Promising clinical results have been obtained for both tolerance and efficacy [1]. The aim of this trial was to determine the optimal dosage, base on a pharmacokinetic-pharmacodynamic analysis of the data obtained from the 15 patients included in this dose-searching study. Biological parameters, such as circulating levels and functional inhibition (as detected in an adhesion assay of patient lymphocytes), were measured during and after treatment. A Hill relation was calculated between the effect and the concentration measured and led us to select a 15 mg/day dose for further clinical trials, with a loading dose of 30 mg. An additional group receiving this protocol was submitted to the same calculation, and the results from this last group were in agreement with this previous analysis.

Published
1996

79. Pathophysiology and clinical studies in CKD 1-5.

Author

El Sharkawy, M., primary, Elsaeed, K., additional, Kamel, M., additional, Aziz, A., additional, Del Pozo, C., additional, Balk, A., additional, Castello-Banyuls, J., additional, Navarro, D., additional, Pere, B., additional, Faura, C. C., additional, Ballesta, J. J., additional, Rodig, N., additional, Vilalta, R., additional, Hernandez, J., additional, Camacho Diaz, J., additional, Lapeyraque, A.- L., additional, Sherwinter, J., additional, Gruppo, R., additional, Fremont, O., additional, Baudouin, V., additional, Langman, C., additional, Simonetti, G. D., additional, Loirat, C., additional, Muus, P., additional, Legendre, C., additional, Douglas, K., additional, Hourmant, M., additional, Delmas, Y., additional, Herthelius, M., additional, Trivelli, A., additional, Goodship, T., additional, Bedrosian, C., additional, Licht, C., additional, Schlesinger, N., additional, Lin, H.- Y., additional, De Meulemeester, M., additional, Rovensky, J., additional, Krammer, G., additional, Balfour, A., additional, So, A., additional, Carrero, J. J., additional, Sonmez, A., additional, Saglam, M., additional, Stenvinkel, P., additional, Yaman, H., additional, Quresi, A. R., additional, Yenicesu, M., additional, Yilmaz, M. I., additional, McQuarrie, E., additional, Freel, M., additional, Mark, P., additional, Patel, R., additional, Steedman, T., additional, Fraser, R., additional, Dargie, H., additional, Connell, J., additional, Jardine, A., additional, Oh, S. W., additional, Chin, H. J., additional, Na, K. Y., additional, Chae, D. W., additional, Alfieri, C., additional, Vettoretti, S., additional, Cafforio, C., additional, Floreani, R., additional, Bonanomi, C., additional, Danzi, G., additional, Messa, P., additional, Whelton, A., additional, MacDonald, P., additional, Hunt, B., additional, Gunawardhana, L., additional, Rusu, E., additional, Voiculescu, M., additional, Zilisteanu, D., additional, Ecobici, M., additional, Arsenescu, I., additional, Ismail, G., additional, Macarie, C., additional, Chan, D., additional, Irish, A., additional, Watts, G., additional, Dogra, G., additional, Krueger, T., additional, Schlieper, G., additional, Cozzolino, M., additional, Eckardt, K. U., additional, Jadoul, M., additional, Ketteler, M., additional, Leunissen, K., additional, Rump, L. C., additional, Wiecek, A., additional, Westenfeld, R., additional, Hilgers, R. D., additional, Mahnken, A. H., additional, Schurgers, L. J., additional, Floege, J., additional, Onuigbo, M., additional, Onuigbo, N., additional, Trevisani, F., additional, Sciarrone Alibrandi, M. T., additional, Bertini, R., additional, Montorsi, F., additional, Delli Carpini, S., additional, Camerota, T. C., additional, Antoniolli, S., additional, Citterio, L., additional, Querques, M., additional, Merlino, L., additional, Manunta, P., additional, Ebah, L., additional, Morgan, J., additional, Brenchley, P., additional, Mitra, S., additional, Krumme, B., additional, Boehler, J., additional, Mettang, T., additional, Strutz, F., additional, Georginova, O., additional, Rykova, S., additional, Gafarova, M., additional, Smyr, K., additional, Sokolova, I., additional, Krasnova, T., additional, and Kozlovskaya, L., additional

Published
2011
Full Text
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92. An open multicenter trial of conversion from sandimmun to neoral in stable kidney-transplant patients

Author

Hourmant, M., primary, Antoine, C., additional, Bayle, F., additional, Bedrossian, J., additional, Berthoux, F., additional, Cassuto, E., additional, Chalopin, J.M., additional, Charpentier, B., additional, Deteix, P., additional, Durand, D., additional, Hurault de Ligny, B., additional, Kessler, M., additional, Kreis, H., additional, Lang, P., additional, Lebranchu, Y., additional, Leroux-Robert, C., additional, Moulin, B., additional, Mourad, G., additional, Noël, C., additional, Olmer, M., additional, Potaux, L., additional, Pouteil-Noble, C., additional, Pruna, A., additional, Sraër, J.D., additional, Touchard, G., additional, Toupance, O., additional, Touraine, J.L., additional, Wolf, P., additional, Puget, S., additional, and Soulillou, J.P., additional

Published
1997
Full Text
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