55,788 results on '"Hong, Wei"'
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52. Long-range order enabled stability in quantum dot light-emitting diodes
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Wang, Ya-Kun, Wan, Haoyue, Teale, Sam, Grater, Luke, Zhao, Feng, Zhang, Zhongda, Duan, Hong-Wei, Imran, Muhammad, Wang, Sui-Dong, Hoogland, Sjoerd, and Liao, Liang-Sheng
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- 2024
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53. Short-Term Changes in Weight, Body Composition, and Metabolic Biomarkers After Laparoscopic Sleeve Gastrectomy in Patients with Obesity: A Comparative Prospective Study
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Hong, Wei, Tang, Wenjuan, Hao, Xiaojun, Tao, Chao, Yin, Pengzhan, Jin, Yan, and Zhou, Yunfeng
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- 2024
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54. Formation of free-surface vortex and vortex suppression by rotating stopper-rod at end of tundish casting
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Fang, Qing, Zhao, Peng, Zhang, Hua, Zhou, Wen-hao, Yu, Gang, Wang, Jia-hui, and Ni, Hong-wei
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- 2024
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55. Stein-Weiss inequality on non-compact symmetric spaces
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Kumar, Vishvesh, Ruzhansky, Michael, and Zhang, Hong-Wei
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Mathematics - Analysis of PDEs ,22E30, 43A85, 43A90 - Abstract
Let $\Delta$ be the Laplace-Beltrami operator on a non-compact symmetric space of any rank, and denote the bottom of its $L^2$-spectrum as $-|\rho|^{2}$. In this paper, we provide a comprehensive characterization of both the sufficient and necessary conditions ensuring the validity of the Stein-Weiss inequality for the entire family of operators $\lbrace{(-\Delta+b)^{-\frac{\sigma}{2}}}\rbrace_{\sigma\ge0,\,b\ge-|\rho|^{2}}$. As an application, some weighted functional inequalities, such as Heisenberg's uncertainty principle, Gagliardo-Nirenberg's interpolation inequality, Pitt's inequality, etc., become available in this context. In particular, their sets of admissible indices are larger than those in the Euclidean setting., Comment: The "fill opacity" feature in Tikz images was automatically disabled in v1. We enable it in this new version
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- 2023
56. Evaluating residual acceleration noise for TianQin with an empirical magnetic field model
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Su, Wei, Zhou, Ze-Bing, Wang, Yan, Zhou, Chen, Chen, P. F., Hong, Wei, Peng, J. H., Yang, Yun, and Ni, Y. W.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics ,General Relativity and Quantum Cosmology ,Physics - Space Physics - Abstract
TianQin (TQ) project plans to deploy three satellites in space around the Earth to measure the displacement change of test masses caused by gravitational waves via laser interferometry. The requirement of the acceleration noise of the test mass is on the order of $10^{-15}~\,{\rm m}\,{\rm s}^{-2}\,{\rm Hz}^{-1/2}$ in the sensitive frequency range of TQ, %the extremely precise acceleration measurement requirements make it necessary to investigate acceleration noise due to space magnetic fields. which is so stringent that the acceleration noise caused by the interaction of the space magnetic field with the test mass needs to be investigated. In this work, by using the Tsyganenko model, a data-based empirical space magnetic field model, we obtain the magnetic field distribution around TQ's orbit spanning two solar cycles in 23 years from 1998 to 2020. With the obtained space magnetic field, we derive the distribution and amplitude spectral densities (ASDs) of the acceleration noise of TQ in 23 years. Our results reveal that the average values of the ratio of the acceleration noise cauesd by the space magnetic field to the requirements of TQ at 1 mHz ($R_{\rm 1mHz}$) and 6 mHz ($R_{\rm 6mHz}$) are 0.123$\pm$0.052 and 0.027$\pm$0.013, respectively. The occurence probabilities of $R_{\rm 1mHz}>0.2$ and $>0.3$ are only 7.9\% and 1.2\%, respectively, and $R_{\rm 6mHz}$ never exceeds 0.2., Comment: 16 pages, 10 figures, Accepted by PRD
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- 2023
57. When Geoscience Meets Foundation Models: Towards General Geoscience Artificial Intelligence System
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Zhang, Hao, Xu, Jin-Jian, Cui, Hong-Wei, Li, Lin, Yang, Yaowen, Tang, Chao-Sheng, and Boers, Niklas
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Computer Science - Artificial Intelligence ,Physics - Geophysics - Abstract
Artificial intelligence (AI) has significantly advanced Earth sciences, yet its full potential in to comprehensively modeling Earth's complex dynamics remains unrealized. Geoscience foundation models (GFMs) emerge as a paradigm-shifting solution, integrating extensive cross-disciplinary data to enhance the simulation and understanding of Earth system dynamics. These data-centric AI models extract insights from petabytes of structured and unstructured data, effectively addressing the complexities of Earth systems that traditional models struggle to capture. The unique strengths of GFMs include flexible task specification, diverse input-output capabilities, and multi-modal knowledge representation, enabling analyses that surpass those of individual data sources or traditional AI methods. This review not only highlights the key advantages of GFMs, but also presents essential techniques for their construction, with a focus on transformers, pre-training, and adaptation strategies. Subsequently, we examine recent advancements in GFMs, including large language models, vision models, and vision-language models, particularly emphasizing the potential applications in remote sensing. Additionally, the review concludes with a comprehensive analysis of the challenges and future trends in GFMs, addressing five critical aspects: data integration, model complexity, uncertainty quantification, interdisciplinary collaboration, and concerns related to privacy, trust, and security. This review offers a comprehensive overview of emerging geoscientific research paradigms, emphasizing the untapped opportunities at the intersection of advanced AI techniques and geoscience. It examines major methodologies, showcases advances in large-scale models, and discusses the challenges and prospects that will shape the future landscape of GFMs., Comment: the manuscript is under review
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- 2023
58. Proton-Boron Fusion Yield Increased by Orders of Magnitude with Foam Targets
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Wei, Wen-Qing, Zhang, Shi-Zheng, Deng, Zhi-Gang, Qi, Wei, Xu, Hao, Liu, Li-Rong, Zhang, Jia-Lin, Li, Fang-Fang, Xu, Xing, Hu, Zhong-Min, Chen, Ben-Zheng, Ma, Bu-Bo, Li, Jian-Xing, Ren, Xue-Guang, Xu, Zhong-Feng, Hoffmann, Dieter H. H., Fan, Quan-Ping, Wang, Wei-Wu, Wang, Shao-Yi, Teng, Jian, Cui, Bo, Lu, Feng, Yang, Lei, Gu, Yu-Qiu, Zhao, Zong-Qing, Cheng, Rui, Wang, Zhao, Lei, Yu, Xiao, Guo-Qing, Zhao, Hong-Wei, Liu, Bing, Zhao, Guan-Chao, Liu, Min-Sheng, Xie, Hua-Sheng, Cao, Lei-Feng, Ren, Jie-Ru, Zhou, Wei-Min, and Zhao, Yong-Tao
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Physics - Plasma Physics - Abstract
A novel intense beam-driven scheme for high yield of the tri-alpha reaction 11B(p,{\alpha})2{\alpha} was investigated. We used a foam target made of cellulose triacetate (TAC, C_9H_{16}O_8) doped with boron. It was then heated volumetrically by soft X-ray radiation from a laser heated hohlraum and turned into a homogenous, and long living plasma. We employed a picosecond laser pulse to generate a high-intensity energetic proton beam via the well-known Target Normal Sheath Acceleration (TNSA) mechanism. We observed up to 10^{10}/sr {\alpha} particles per laser shot. This constitutes presently the highest yield value normalized to the laser energy on target. The measured fusion yield per proton exceeds the classical expectation of beam-target reactions by up to four orders of magnitude under high proton intensities. This enhancement is attributed to the strong electric fields and nonequilibrium thermonuclear fusion reactions as a result of the new method. Our approach shows opportunities to pursue ignition of aneutronic fusion.
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- 2023
59. Proprioceptive Learning with Soft Polyhedral Networks
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Liu, Xiaobo, Han, Xudong, Hong, Wei, Wan, Fang, and Song, Chaoyang
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Computer Science - Robotics ,Computer Science - Machine Learning - Abstract
Proprioception is the "sixth sense" that detects limb postures with motor neurons. It requires a natural integration between the musculoskeletal systems and sensory receptors, which is challenging among modern robots that aim for lightweight, adaptive, and sensitive designs at a low cost. Here, we present the Soft Polyhedral Network with an embedded vision for physical interactions, capable of adaptive kinesthesia and viscoelastic proprioception by learning kinetic features. This design enables passive adaptations to omni-directional interactions, visually captured by a miniature high-speed motion tracking system embedded inside for proprioceptive learning. The results show that the soft network can infer real-time 6D forces and torques with accuracies of 0.25/0.24/0.35 N and 0.025/0.034/0.006 Nm in dynamic interactions. We also incorporate viscoelasticity in proprioception during static adaptation by adding a creep and relaxation modifier to refine the predicted results. The proposed soft network combines simplicity in design, omni-adaptation, and proprioceptive sensing with high accuracy, making it a versatile solution for robotics at a low cost with more than 1 million use cycles for tasks such as sensitive and competitive grasping, and touch-based geometry reconstruction. This study offers new insights into vision-based proprioception for soft robots in adaptive grasping, soft manipulation, and human-robot interaction., Comment: 20 pages, 10 figures, 2 tables, Published in the International Journal of Robotics Research
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- 2023
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60. Study on the possible molecular states composed of $\Lambda_c\bar D^*$, $\Sigma_c\bar D^*$, $\Xi_c\bar D^*$ and $\Xi_c'\bar D^*$ in the Bethe-Salpeter frame based on the pentaquark states $P_c(4440)$, $P_c(4457)$ and $P_{cs}(4459)$
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Ke, Hong-Wei, Lu, Fang, Pang, Hai, Liu, Xiao-Hai, and Li, Xue-Qian
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment - Abstract
The measurements on a few pentaquarks states $P_c(4440)$, $P_c(4457)$ and $P_{cs}(4459)$ excite our new interests about their structures. Since the masses of $P_c(4440)$ and $P_c(4457)$ are close to the threshold of $\Sigma_c\bar D^*$, in the earlier works, they were regarded as molecular states of $\Sigma_c\bar D^*$ with quantum numbers $I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$ and $\frac{1}{2}(\frac{3}{2}^-)$, respectively. In a similar way $P_{cs}(4459)$ is naturally considered as a $\Xi_c\bar D^*$ bound state with $I=0$. Within the Bethe-Salpeter (B-S) framework we systematically study the possible bound states of $\Lambda_c\bar D^*$, $\Sigma_c\bar D^*$, $\Xi_c\bar D^*$ and $\Xi_c'\bar D^*$. Our results indicate that $\Sigma_c\bar D^*$ can form a bound state with $I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$, which corresponds to $P_c(4440)$. However for the $I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$ system the attraction between $\Sigma_c$ and $\bar D^*$ is too weak to constitute a molecule, so $P_{c}(4457)$ may not be a bound state of $\Sigma_c\bar D^*$ with $I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$. As $\Xi_c\bar D^*$ and $\Xi_c'\bar D^*$ systems we take into account of the mixing between $\Xi_c$ and $\Xi'_c$ and the eigenstets should include two normal bound states $\Xi_c\bar D^*$ and $\Xi_c'\bar D^*$ with $I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$ and a loosely bound state $\Xi_c\bar D^*$ with $I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$. The conclusion that two $\Xi_c\bar D^*$ bound states exist, supports the suggestion that the observed peak of $P_{cs}(4459)$ may hide two states $P_{cs}(4455)$ and $P_{cs}(4468)$. Based on the computations we predict a bound state $\Xi_c'\bar D^*$ with $I(J^P)=\frac{1}{2}(\frac{1}{2}^-)$ but not that with $I(J^P)=\frac{1}{2}(\frac{3}{2}^-)$. Further more accurate experiments will test our approach and results., Comment: 24 pages, 2 figures and 12 tables. arXiv admin note: text overlap with arXiv:1909.12509
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- 2023
61. A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma
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Everman, Jamie L, Sajuthi, Satria P, Liegeois, Maude A, Jackson, Nathan D, Collet, Erik H, Peters, Michael C, Chioccioli, Maurizio, Moore, Camille M, Patel, Bhavika B, Dyjack, Nathan, Powell, Roger, Rios, Cydney, Montgomery, Michael T, Eng, Celeste, Elhawary, Jennifer R, Mak, Angel CY, Hu, Donglei, Huntsman, Scott, Salazar, Sandra, Feriani, Luigi, Fairbanks-Mahnke, Ana, Zinnen, Gianna L, Michel, Cole R, Gomez, Joe, Zhang, Xing, Medina, Vivian, Chu, Hong Wei, Cicuta, Pietro, Gordon, Erin D, Zeitlin, Pamela, Ortega, Victor E, Reisdorph, Nichole, Dunican, Eleanor M, Tang, Monica, Elicker, Brett M, Henry, Travis S, Bleecker, Eugene R, Castro, Mario, Erzurum, Serpil C, Israel, Elliot, Levy, Bruce D, Mauger, David T, Meyers, Deborah A, Sumino, Kaharu, Gierada, David S, Hastie, Annette T, Moore, Wendy C, Denlinger, Loren C, Jarjour, Nizar N, Schiebler, Mark L, Wenzel, Sally E, Woodruff, Prescott G, Rodriguez-Santana, Jose, Pearson, Chad G, Burchard, Esteban G, Fahy, John V, and Seibold, Max A
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Biochemistry and Cell Biology ,Biomedical and Clinical Sciences ,Biological Sciences ,Asthma ,Lung ,Genetics ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Respiratory ,Child ,Humans ,Cytokines ,Epithelial Cells ,GPI-Linked Proteins ,Interleukin-13 ,Lectins ,Mucin 5AC ,Mucus ,Nasal Mucosa ,Polymorphism ,Genetic ,Respiratory Mucosa - Abstract
By incompletely understood mechanisms, type 2 (T2) inflammation present in the airways of severe asthmatics drives the formation of pathologic mucus which leads to airway mucus plugging. Here we investigate the molecular role and clinical significance of intelectin-1 (ITLN-1) in the development of pathologic airway mucus in asthma. Through analyses of human airway epithelial cells we find that ITLN1 gene expression is highly induced by interleukin-13 (IL-13) in a subset of metaplastic MUC5AC+ mucus secretory cells, and that ITLN-1 protein is a secreted component of IL-13-induced mucus. Additionally, we find ITLN-1 protein binds the C-terminus of the MUC5AC mucin and that its deletion in airway epithelial cells partially reverses IL-13-induced mucostasis. Through analysis of nasal airway epithelial brushings, we find that ITLN1 is highly expressed in T2-high asthmatics, when compared to T2-low children. Furthermore, we demonstrate that both ITLN-1 gene expression and protein levels are significantly reduced by a common genetic variant that is associated with protection from the formation of mucus plugs in T2-high asthma. This work identifies an important biomarker and targetable pathways for the treatment of mucus obstruction in asthma.
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- 2024
62. Interference mitigation and target detection for automotive FMCW radar with range-Doppler sparse regularization
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Huang, Yan, Wang, Yunxuan, Zhou, Xiao, Zhang, Hui, Mao, Yuan, Liao, Guisheng, and Hong, Wei
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- 2024
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63. Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease
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Li-Ming Chen, Min Kang, Jun-Yi Wang, San-Hua Xu, Cheng Chen, Hong Wei, Qian Ling, Liang-Qi He, Jie Zou, Yi-Xin Wang, Xu Chen, Ping Ying, Hui Huang, Yi Shao, and Rui Wu
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connective tissue desease-related interstitial lung disease ,optical coherence tomography angiography ,microvessel density ,ocular surface ,retina ,Ophthalmology ,RE1-994 - Abstract
AIM: To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease (CTD-ILD) and healthy controls (HCs) by optical coherence tomography angiography (OCTA) and to investigate the changes in microvascular density in abnormal eyes. METHODS: For a retrospective case-control study, a total of 16 patients (32 eyes) diagnosed with CTD-ILD were selected as the ILD group. The 16 healthy volunteers with 32 eyes, matched in terms of age and sex with the patients, were recruited as control group. The macular retina's superficial retinal layer (SRL) and deep retinal layer (DRL) were examined and scanned using OCTA in each individual eye. The densities of retinal microvascular (MIR), macrovascular (MAR), and total microvascular (TMI) were calculated and compared. Changes in retinal vascular density in the macular region were analyzed using three different segmentation methods: central annuli segmentation method (C1-C6), hemispheric segmentation method [uperior right (SR), superior left (SL), inferior left (IL), and inferior right (IR)], and Early Treatment Diabetic Retinopathy Study (ETDRS) methods [superior (S), inferior (I), left (L), and right (R)]. The data were analyzed using Version 9.0 of GraphPad prism and Pearson analysis. RESULTS: The OCTA data demonstrated a statistically significant difference (P
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- 2024
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64. Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
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Cheng Lian, Chunyi Zhang, Pan Tian, Qilong Tan, Yu Wei, Zixian Wang, Qin Zhang, Qixiang Zhang, Mengjie Zhong, Li-Quan Zhou, Xisong Ke, Huabing Zhang, Yao Zhu, Zhenfei Li, Jingdong Cheng, and Gong-Hong Wei
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Medicine ,Biology (General) ,QH301-705.5 - Abstract
Abstract Epigenetic readers frequently affect gene regulation, correlate with disease prognosis, and hold significant potential as therapeutic targets for cancer. Zinc finger MYND-type containing 11 (ZMYND11) is notably recognized for reading the epigenetic marker H3.3K36me3; however, its broader functions and mechanisms of action in cancer remain underexplored. Here, we report that ZMYND11 downregulation is prevalent across various cancers and profoundly correlates with poorer outcomes in prostate cancer patients. Depletion of ZMYND11 promotes tumor cell growth, migration, and invasion in vitro, as well as tumor formation and metastasis in vivo. Mechanistically, we discover that ZMYND11 exhibits tumor suppressive roles by recognizing arginine-194-methylated HNRNPA1 dependent on its MYND domain, thereby retaining HNRNPA1 in the nucleus and preventing the formation of stress granules in the cytoplasm. Furthermore, ZMYND11 counteracts the HNRNPA1-driven increase in the PKM2/PKM1 ratio, thus mitigating the aggressive tumor phenotype promoted by PKM2. Remarkably, ZMYND11 recognition of HNRNPA1 can be disrupted by pharmaceutical inhibition of the arginine methyltransferase PRMT5. Tumors with low ZMYND11 expression show sensitivity to PRMT5 inhibitors. Taken together, our findings uncover a previously unexplored noncanonical role of ZMYND11 as a nonhistone methylation reader and underscore the critical importance of arginine methylation in the ZMYND11-HNRNPA1 interaction for restraining tumor progression, thereby proposing novel therapeutic targets and potential biomarkers for cancer treatment.
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- 2024
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65. Altered spontaneous brain activity patterns in hypertensive retinopathy using fractional amplitude of low-frequency fluctuations: a functional magnetic resonance imaging study
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Xue-Lin Wang, Xu-Jun Zheng, Li-Juan Zhang, Jin-Yu Hu, Hong Wei, Qian Ling, Liang-Qi He, Cheng Chen, Yi-Xin Wang, Xu Chen, and Yi Shao
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hypertensive retinopathy ,fractional amplitude of low-frequency fluctuation ,brain region ,magnetic resonance imaging ,Ophthalmology ,RE1-994 - Abstract
AIM: To study functional brain abnormalities in patients with hypertensive retinopathy (HR) and to discuss the pathophysiological mechanisms of HR by fractional amplitude of low-frequency fluctuations (fALFFs) method. METHODS: Twenty HR patients and 20 healthy controls (HCs) were respectively recruited. The age, gender, and educational background characteristics of the two groups were similar. After functional magnetic resonance imaging (fMRI) scanning, the subjects' spontaneous brain activity was evaluated with the fALFF method. Receiver operating characteristic (ROC) curve analysis was used to classify the data. Further, we used Pearson's correlation analysis to explore the relationship between fALFF values in specific brain regions and clinical behaviors in patients with HR. RESULTS: The brain areas of the HR group with lower fALFF values than HCs were the right orbital part of the middle frontal gyrus (RO-MFG) and right lingual gyrus. In contrast, the values of fALFFs in the left middle temporal gyrus (MTG), left superior temporal pole (STP), left middle frontal gyrus (MFG), left superior marginal gyrus (SMG), left superior parietal lobule (SPL), and right supplementary motor area (SMA) were higher in the HR group. The results of a t-test showed that the average values of fALFFs were statistically significantly different in the HR group and HC group (P
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- 2024
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66. Investigation on the characteristics of porosity, melt pool in 316L stainless steel manufactured by laser powder bed fusion
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Cheng-song Liu, Xiao Xue, Yong Wang, Hua Zhang, Jie Li, Yuan-yuan Lu, Li Xiong, and Hong-wei Ni
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Laser powder bed fusion ,316L stainless steel ,Melting pool ,Pore characteristics ,Mining engineering. Metallurgy ,TN1-997 - Abstract
Pores are among the primary defects in 316L stainless steel when fabricated through laser powder bed fusion (L-PBF). To better understand and precisely control the formation behavior of pores in the L-PBF-manufactured 316L stainless steel, effects of L-PBF process parameters on the melt pool and pore characteristics have been investigated. A method utilized for extreme values statistics analysis was also applied to investigate and predict the sizes of pores. Relationships among the count of measurements, the laser energy density, the reduced variate, and the maximum pore size were revealed. The findings showed an overall increase in melt pool depth as the laser energy densities was raised, yet the magnitude of this growth weakened as the laser energy density continued to increase. Conversely, it was discovered that the connection between the width of the melt pool and the density of laser energy exhibited a markedly less distinct correlation. As laser energy density escalated, there was a shift in the melt pool mode from conduction-based to a transitional phase, and upon further elevation of the laser energy density, it transitioned to keyhole mode. To obtain a reliable statistical analysis of pores, at least 40 measurements should be acquired for the estimation of the pore sizes by taking comprehensive consideration of time cost. Beside, in all three melt pool modes, at a fixed observation area, the maximum size of pores generally decreased with the escalation in laser energy densities.
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- 2024
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67. Application of Seismic Signal Harmonic Frequency Enhancement Technology for Fine Identification of Braided River Sand Bodies
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Hong WEI, Qingyun BAI, Jialin SUN, Pengzhi ZHANG, and Yuntao MENG
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seismic signal ,harmonics ,braided river sand bodies ,resolution ,Geophysics. Cosmic physics ,QC801-809 ,Medicine (General) ,R5-920 - Abstract
Many oil fields in the Bohai Oilfield are currently in the stage of high water cut and low recovery. Thus, it is urgent to conduct in-depth research on the potential of these oil fields to maintain stable production. After 20 years of directional well development, Bohai B Oilfield has developed a set of layers with combined production and strong injection, resulting in severe interlayer interference and difficulties in tapping the potential of the remaining oil. Owing to the limited resolution of existing seismic data, it is not possible to identify the reservoir structure inside the braided river composite sand body, including the vertical and horizontal distribution of the interlayer and thin sand body. Therefore, directional well development is currently mainly used. Here, the seismic signal harmonic frequency enhancement technology is proposed, which directly uses the fundamental component of seismic data to predict harmonic and subharmonic information, and then adds it to the original seismic data to expand the high-frequency and low-frequency seismic information, achieving the purpose of frequency enhancement. This method overcomes the limitations of traditional convolutional models, eliminating the need of well information and to estimate seismic wavelets and assume sparse stratigraphic reflection coefficients, thereby reducing the human subjective factors. The research results, verified through dynamic and static information, showed that the seismic signal harmonic frequency enhancement technology can effectively and finely identify the internal structure of braided river sand bodies, help to transform directional wells into horizontal wells for development, avoid interlayer interference, and promote efficient extraction of the remaining oil.
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- 2024
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68. Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases
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Hang Zhou, Chunyan Zhu, Qing Zhao, Jinliang Ni, Haipeng Zhang, Guangcan Yang, Jianchao Ge, Chao Fang, Hong Wei, Xianli Zhou, and Kun Zhang
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Neutrophil extracellular traps ,Cancer-associated neurotransmitters ,Interpenetrating network hydrogels ,Postsurgical cancer relapse and metastases ,Immunosuppressive tumor microenvironment ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Tumor-promoting niche after incomplete surgery resection (SR) can lead to more aggressive local progression and distant metastasis with augmented angiogenesis-immunosuppressive tumor microenvironment (TME). Herein, elevated neutrophil extracellular traps (NETs) and cancer-associated neurotransmitters (CANTs, e.g., catecholamines) are firstly identified as two of the dominant inducements. Further, an injectable fibrin-alginate hydrogel with high tissue adhesion has been constructed to specifically co-deliver NETs inhibitor (DNase I)-encapsulated PLGA nanoparticles and an unselective β-adrenergic receptor blocker (propranolol). The two components (i.e., fibrin and alginate) can respond to two triggers (thrombin and Ca2+, respectively) in postoperative bleeding to gelate, shaping into an interpenetrating network (IPN) featuring high strength. The continuous release of DNase I and PR can wreck NETs and antagonize catecholamines to decrease microvessel density, blockade myeloid-derived suppressor cells, secrete various proinflammatory cytokines, potentiate natural killer cell function and hamper cytotoxic T cell exhaustion. The reprogrammed TME significantly suppress locally residual and distant tumors, induce strong immune memory effects and thus inhibit lung metastasis. Thus, targetedly degrading NETs and blocking CANTs enabled by this in-situ IPN-based hydrogel drug depot provides a simple and efficient approach against SR-induced cancer recurrence and metastasis.
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- 2024
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69. Innovative Thin PiG Plates Boost the Luminous Efficacy and Reliability of WLEDs for Vehicles
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Hong-Wei Huang, Chien-Wei Huang, Yi-Chian Chen, Wei-Chih Cheng, Chun-Nien Liu, and Chia-Chin Chiang
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phosphor-in-glass ,white LED ,thin plate ,Technology ,Chemical technology ,TP1-1185 - Abstract
In this study, we demonstrate the high luminous efficacy of 118 lm/W and the high reliability of white LEDs (WLEDs) through 450 °C thermal aging, utilizing four-inch YAG: Ce3+ phosphor-in-glass (PiG) plates designed for vehicle headlights. The sintering process of mixing glass and phosphor typically generates pores, which can scatter light and reduce the luminous efficacy of the fabricated PiG. In this study, we produced four-inch PiG plates under four different fabrication conditions to evaluate their luminous efficacy. Our results revealed that the PiG plate with a thin thickness of 0.08 mm exhibited a 16.83% increase in luminous efficacy compared to the 0.15 mm plate, attributed to reduced light interaction with the pores. Unlike silicone-based phosphor WLEDs, which offer high performance but lower reliability due to the silicone resin’s low transition temperature (150 °C), our novel thin PiG plate achieves high performance and reliability. This advancement suggests that the proposed thin PiG plate could replace traditional silicone-based phosphors, enabling the development of high-quality WLEDs for vehicle headlights in automotive applications.
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- 2024
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70. Giant retroperitoneal liposarcoma with multiple organ involvement: a case report and literature review
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Jia-Ning Sun, Rui Yang, Xiao-Lu Jiang, Feng Zhang, and Hong-Wei Zhao
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Retroperitoneal liposarcoma ,Giant size ,Diagnosis ,Combined organ resection ,Case report ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Retroperitoneal liposarcoma (RPLPS) is a relatively rare disease. Liposarcomas vary in size, but sizeable RPLPS larger than 30 cm in diameter are very rare, and their diagnosis and treatment present significant challenges. Case presentation We report a 58-year-old male patient who was admitted to the hospital with an increased abdominal circumference and was later diagnosed with a giant RPLPS. The liposarcoma was found to adhere to the right kidney and the entire ureter, invading the ascending colon. The patient underwent complete combined surgical resection. The tumor was removed intact, measured 55.0 cm × 30.0 cm × 18.0 cm, and weighed 19.8 kg. Histopathologic analysis revealed well-differentiated liposarcoma (WDLPS). The patient was successfully discharged from the hospital and followed up for 6 months with no signs of recurrence. Conclusion RPLPS is a rare tumor with atypical clinical presentation. Surgery remains the most effective method of treatment for retroperitoneal sarcomas, with complete removal if there is local invasion. Preoperative examination, including three-dimensional (3D) reconstruction, is essential for surgical success. The role of adjuvant radiotherapy or chemotherapy remains controversial. However, clinicians should not rule them out as viable options.
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- 2024
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71. Pterostilbene improves neurological dysfunction and neuroinflammation after ischaemic stroke via HDAC3/Nrf1-mediated microglial activation
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Yuhua Chen, Wei He, Junlin Qiu, Yangyang Luo, Chenlong Jiang, Feng Zhao, Hong Wei, Jiao Meng, Tianlin Long, Xin Zhang, Lingjian Yang, Quanhua Xu, Juning Wang, and Chi Zhang
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Ischaemic stroke ,PTS ,HDAC3 ,Nrf1 acetylation ,Neuroinflammation ,Cytology ,QH573-671 - Abstract
Abstract Background Stroke is a type of acute brain damage that can lead to a series of serious public health challenges. Demonstrating the molecular mechanism of stroke-related neural cell degeneration could help identify a more efficient treatment for stroke patients. Further elucidation of factors that regulate microglia and nuclear factor (erythroid-derived 2)-like 1 (Nrf1) may lead to a promising strategy for treating neuroinflammation after ischaemic stroke. In this study, we investigated the possible role of pterostilbene (PTS) in Nrf1 regulation in cell and animal models of ischaemia stroke. Methods We administered PTS, ITSA1 (an HDAC activator) and RGFP966 (a selective HDAC3 inhibitor) in a mouse model of middle cerebral artery occlusion–reperfusion (MCAO/R) and a model of microglial oxygen‒glucose deprivation/reperfusion (OGD/R). The brain infarct size, neuroinflammation and microglial availability were also determined. Dual-luciferase reporter, Nrf1 protein stability and co-immunoprecipitation assays were conducted to analyse histone deacetylase 3 (HDAC3)/Nrf1-regulated Nrf1 in an OGD/R-induced microglial injury model. Results We found that PTS decreased HDAC3 expression and activity, increased Nrf1 acetylation in the cell nucleus and inhibited the interaction of Nrf1 with p65 and p65 accumulation, which reduced infarct volume and neuroinflammation (iNOS/Arg1, TNF-α and IL-1β levels) after ischaemic stroke. Furthermore, the CSF1R inhibitor PLX5622 induced elimination of microglia and attenuated the therapeutic effect of PTS following MCAO/R. In the OGD/R model, PTS relieved OGD/R-induced microglial injury and TNF-α and IL-1β release, which were dependent on Nrf1 acetylation through the upregulation of HDAC3/Nrf1 signalling in microglia. However, the K105R or/and K139R mutants of Nrf1 counteracted the impact of PTS in the OGD/R-induced microglial injury model, which indicates that PTS treatment might be a promising strategy for ischaemia stroke therapy. Conclusion The HDAC3/Nrf1 pathway regulates the stability and function of Nrf1 in microglial activation and neuroinflammation, which may depend on the acetylation of the lysine 105 and 139 residues in Nrf1. This mechanism was first identified as a potential regulatory mechanism of PTS-based neuroprotection in our research, which may provide new insight into further translational applications of natural products such as PTS.
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- 2024
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72. Self-assembled superstructure alleviates air-water interface effect in cryo-EM
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Liming Zheng, Jie Xu, Weihua Wang, Xiaoyin Gao, Chao Zhao, Weijun Guo, Luzhao Sun, Hang Cheng, Fanhao Meng, Buhang Chen, Weiyu Sun, Xia Jia, Xiong Zhou, Kai Wu, Zhongfan Liu, Feng Ding, Nan Liu, Hong-Wei Wang, and Hailin Peng
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Science - Abstract
Abstract Cryo-electron microscopy (cryo-EM) has been widely used to reveal the structures of proteins at atomic resolution. One key challenge is that almost all proteins are predominantly adsorbed to the air-water interface during standard cryo-EM specimen preparation. The interaction of proteins with air-water interface will significantly impede the success of reconstruction and achievable resolution. Here, we highlight the critical role of impenetrable surfactant monolayers in passivating the air-water interface problems, and develop a robust effective method for high-resolution cryo-EM analysis, by using the superstructure GSAMs which comprises surfactant self-assembled monolayers (SAMs) and graphene membrane. The GSAMs works well in enriching the orientations and improving particle utilization ratio of multiple proteins, facilitating the 3.3-Å resolution reconstruction of a 100-kDa protein complex (ACE2-RBD), which shows strong preferential orientation using traditional specimen preparation protocol. Additionally, we demonstrate that GSAMs enables the successful determinations of small proteins (
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- 2024
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73. Basis-independent quantum coherence and its distribution under relativistic motion
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Ming-Ming Du, Hong-Wei Li, Zhen Tao, Shu-Ting Shen, Xiao-Jing Yan, Xi-Yun Li, Wei Zhong, Yu-Bo Sheng, and Lan Zhou
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Astrophysics ,QB460-466 ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
Abstract Recent studies have increasingly focused on the effect of relativistic motion on quantum coherence. Prior research predominantly examined the influence of relative motion on basis-dependent quantum coherence, underscoring its susceptibility to decoherence under accelerated conditions. Yet, the effect of relativistic motion on basis-independent quantum coherence, which is critical for understanding the intrinsic quantum features of a system, remains an interesting open question. This paper addresses this question by examining how total, collective, and localized coherence are affected by acceleration and coupling strength. Our analysis reveals that both total and collective coherence significantly decrease with increasing acceleration and coupling strength, ultimately vanishing at high levels of acceleration. This underscores the profound impact of Unruh thermal noise. Conversely, localized coherence exhibits relative stability, decreasing to zero only under the extreme condition of infinite acceleration. Moreover, we demonstrate that collective, localized, and basis-independent coherence collectively satisfy the triangle inequality. These findings are crucial for enhancing our understanding of quantum information dynamics in environments subjected to high acceleration and offer valuable insights on the behavior of quantum coherence under relativistic conditions.
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- 2024
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74. Reduction of eEF2 kinase alleviates the learning and memory impairment caused by acrylamide
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Xiao-Li Wang, Ru-Nan Zhang, Yu-Lin Pan, Zhi-Ming Li, Hong-Qiu Li, Ya-Ting Lei, Fang-Fang Zhao, Xiao-Xiao Hao, Wei-Wei Ma, Cui-Ping Yu, Hong-Wei Yao, Xin-Yu Wang, Jun-Jie Lv, Yong-Hui Wu, and Sheng-Yuan Wang
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Acrylamide ,Occupational exposure ,eEF2K ,Learning and memory ,Ether lipid metabolism ,Biotechnology ,TP248.13-248.65 ,Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Abstract
Abstract Background The impact of acrylamide (ACR) on learning and memory has garnered considerable attention. However, the targets and mechanisms are still unclear. Results Elongation factor 2 (eEF2) was significantly upregulated in the results of serum proteomics. Results from in vitro and in vivo experiments indicated a notable upregulation of Eukaryotic elongation factor 2 kinase (eEF2K), the sole kinase responsible for eEF2 phosphorylation, following exposure to ACR (P
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- 2024
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75. Retinal microvascular changes in patients with pancreatitis and their clinical significance
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Yun-Qing Luo, Zi-Song Xu, Jin-Yu Hu, Qian-Min Ge, Jie Zou, Hong Wei, Xian-Mei Zhou, Xuan Liao, Qian Ling, Liang-Qi He, Cheng Chen, Xiao-Yu Wang, Yan-Mei Zeng, and Yi Shao
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Pancreatitis ,Optical coherence tomography angiography ,Microvascular density ,Medicine ,Science - Abstract
Abstract Acute pancreatitis, a common exocrine inflammatory disease affecting the pancreas, is characterized by intense abdominal pain and multiple organ dysfunction. However, the alterations in retinal blood vessels among individuals with acute pancreatitis remain poorly understood. This study employed optical coherence tomography angiography (OCTA) to examine the superficial and deep retinal blood vessels in patients with pancreatitis. Sixteen patients diagnosed with pancreatitis (32 eyes) and 16 healthy controls (32 eyes) were recruited from the First Affiliated Hospital of Nanchang University for participation in the study. Various ophthalmic parameters, such as visual acuity, intraocular pressure, and OCTA image for retina consisting of the superficial retinal layer (SRL) and the deep retinal layer (DRL), were recorded for each eye. The study observed the superficial and deep retinal microvascular ring (MIR), macrovascular ring (MAR), and total microvessels (TMI) were observed. Changes in retinal vascular density in the macula through annular partitioning (C1–C6), hemispheric quadrant partitioning (SR, SL, IL, and IR), and early diabetic retinopathy treatment studies (ETDRS) partitioning methods (R, S, L, and I). Correlation analysis was employed to investigate the relationship between retinal capillary density and clinical indicators. Our study revealed that in the superficial retinal layer, the vascular density of TMI, MIR, MAR, SR, IR, S, C2, C3 regions were significantly decreased in patients group compared with the normal group. For the deep retinal layer, the vascular density of MIR, SR, S, C1, C2 regions also reduced in patient group. The ROC analysis demonstrated that OCTA possesses significant diagnostic performance for pancreatitis. In conclusion, patients with pancreatitis may have retinal microvascular dysfunction, and OCTA can be a valuable tool for detecting alterations in ocular microcirculation in pancreatitis patients in clinical practice.
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- 2024
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76. The interplay between metal ions and immune cells in glioma: pathways to immune escape
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Jin-wei Li, Yi-ming Mao, Shi-liang Chen, Rui Ye, Yi-ran Fei, Yue Li, Shi-yuan Tong, Hong-wei Yang, and Yi-bo He
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Glioma ,Metal ions ,Immune evasion ,Oxidative stress ,Angiogenesis ,Therapeutic strategies ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract This review explores the intricate roles of metal ions—iron, copper, zinc, and selenium—in glioma pathogenesis and immune evasion. Dysregulated metal ion metabolism significantly contributes to glioma progression by inducing oxidative stress, promoting angiogenesis, and modulating immune cell functions. Iron accumulation enhances oxidative DNA damage, copper activates hypoxia-inducible factors to stimulate angiogenesis, zinc influences cell proliferation and apoptosis, and selenium modulates the tumor microenvironment through its antioxidant properties. These metal ions also facilitate immune escape by upregulating immune checkpoints and secreting immunosuppressive cytokines. Targeting metal ion pathways with therapeutic strategies such as chelating agents and metalloproteinase inhibitors, particularly in combination with conventional treatments like chemotherapy and immunotherapy, shows promise in improving treatment efficacy and overcoming resistance. Future research should leverage advanced bioinformatics and integrative methodologies to deepen the understanding of metal ion-immune interactions, ultimately identifying novel biomarkers and therapeutic targets to enhance glioma management and patient outcomes.
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- 2024
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77. Prevalence and genotype distribution of human papillomavirus infection among 66000 women from 2014 to 2023 in the plateau region of Southwest China
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Jian-Peng Hu, Jun-Ling Wang, Yun Li, Yuan Feng, Can-Qiong Tian, Guo-Hui Zhang, Xue-Qin Chen, Hong-Xia Liu, Jin-Si Yang, Zhe-Wei Fang, Yao-Xing Li, Zong-Sheng Wu, Rui Zhu, Xiu-Ping Li, Qian Xiong, Lian-Hao Gao, Ting Ji, Jian-Dong Zhang, Jian-Mei Song, Qi Chen, Shu-Min Li, Fei He, Chun-Ju Yang, and Hong-Wei Li
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Human papillomavirus ,Genotypes ,Cervical cancer ,Prevalence ,Vaccine ,Plateau region of Southwest China ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Persistent infection with high-risk human papillomavirus (HR-HPV) plays a key role in the onset of cervical cancer. This study was designed to examine the epidemiological trends and genotype distribution of HPV from 2014 to 2023 in the plateau region of Southwest China. Methods The findings could offer valuable insights for clinical screening of cervical cancer and the formulation of HPV vaccination policies. This retrospective study analyzed 66,000 women who received HPV-DNA testing at the First People’s Hospital of Qujing, Yunnan, China, between 2014 and 2023. The cohort consisted of 33,512 outpatients, 3,816 inpatients, and 28,672 individuals undergoing health examinations. Cervical cells were collected for DNA extraction, and PCR amplification along with Luminex xMAP technology were used to detect 27 HPV genotypes. The data analysis was conducted using GraphPad Prism and IBM SPSS Statistics 27 software. Results The overall HPV infection rate at the First People’s Hospital of Qujing declined from 24.92% in 2014 to 16.29% in 2023, averaging 16.02%. Specific infection rates were 18.50% among outpatients, 12.97% among inpatients, and 13.53% for health examination attendees. The predominant high-risk HPV genotypes identified were HPV52 (2.61%), HPV16 (2.06%), HPV58 (1.81%), HPV53 (1.55%), and HPV39 (1.09%). Meanwhile, the most frequent low-risk HPV genotypes were HPV6 (1.30%), HPV61 (1.21%), and HPV11 (0.85%). In HPV-positive cases, the distribution of single, double, triple, and quadruple or more infections were 79.90%, 15.17%, 3.59%, and 1.33%, respectively. The proportions of pure LR-HPV, pure HR-HPV, and mixed infections were 22.16%, 67.82%, and 10.02%, respectively. Age-specific analysis revealed a bimodal distribution of HPV infection, with the infection rate rapidly decreasing from 44.02% in the ≤ 19 age group to 19.55% in the 20–29 age group and 13.84% in the 30–39 age group, followed by a gradual increase to 14.64% in the 40–49 age group, 16.65% in the 50–59 age group, and 22.98% in the ≥ 60 age group. The coverage rates of the three available vaccines are all below 50%. The results of this study indicated a declining trend in HPV prevalence in the plateau region of Southwest China over the period from 2014 to 2023, especially in the reduction of genotypes targeted by vaccines. Conclusion There were significant variations in the genotypes prevalent among different age groups, years, and patient sources within the same region. The underwhelming vaccination rates emphasize the critical need for developing either a multivalent vaccine or a personalized vaccine that targets the HPV genotypes common in the Chinese population. Furthermore, vaccinating adolescents to curb HPV infection and ensuring regular cervical cancer screenings for postmenopausal women are crucial steps.
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- 2024
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78. FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis
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Jing Lin, Hong-wei Lin, Yu-xing Wang, Yan Fang, Hui-mian Jiang, Ting Li, Jia Huang, Hua-dong Zhang, Da-zhi Chen, and Yong-ping Chen
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Fibroblast growth factor 4 ,Experimental autoimmune hepatitis ,M1 macrophage polarization ,PI3K/AKT signal pathway ,Medicine - Abstract
Abstract Background The global prevalence of autoimmune hepatitis (AIH) is increasing due in part to the lack of effective pharmacotherapies. Growing evidence suggests that fibroblast growth factor 4 (FGF4) is crucial for diverse aspects of liver pathophysiology. However, its role in AIH remains unknown. Therefore, we investigated whether FGF4 can regulate M1 macrophage and thereby help treat liver inflammation in AIH. Methods We obtained transcriptome-sequencing and clinical data for patients with AIH. Mice were injected with concanavalin A to induce experimental autoimmune hepatitis (EAH). The mechanism of action of FGF4 was examined using macrophage cell lines and bone marrow-derived macrophages. Results We observed higher expression of markers associated with M1 and M2 macrophages in patients with AIH than that in individuals without AIH. EAH mice showed greater M1-macrophage polarization than control mice. The expression of M1-macrophage markers correlated positively with FGF4 expression. The loss of hepatic Fgf4 aggravated hepatic inflammation by increasing the abundance of M1 macrophages. In contrast, the pharmacological administration of FGF4 mitigated hepatic inflammation by reducing M1-macrophage levels. The efficacy of FGF4 treatment was compromised following the in vivo clearance of macrophage populations. Mechanistically, FGF4 treatment activated the phosphatidylinositol 3-kinase (PI3K)–protein kinase B (AKT)-signal pathway in macrophages, which led to reduced M1 macrophages and hepatic inflammation. Conclusion We identified FGF4 as a novel M1/M2 macrophage-phenotype regulator that acts through the PI3K–AKT-signaling pathway, suggesting that FGF4 may represent a novel target for treating inflammation in patients with AIH.
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- 2024
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79. Wave equation on general noncompact symmetric spaces
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Anker, Jean-Philippe and Zhang, Hong-Wei
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- 2024
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80. NTIRE 2023 Quality Assessment of Video Enhancement Challenge
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Liu, Xiaohong, Min, Xiongkuo, Sun, Wei, Zhang, Yulun, Zhang, Kai, Timofte, Radu, Zhai, Guangtao, Gao, Yixuan, Cao, Yuqin, Kou, Tengchuan, Dong, Yunlong, Jia, Ziheng, Li, Yilin, Wu, Wei, Hu, Shuming, Deng, Sibin, Xiao, Pengxiang, Chen, Ying, Li, Kai, Zhao, Kai, Yuan, Kun, Sun, Ming, Cong, Heng, Wang, Hao, Fu, Lingzhi, Zhang, Yusheng, Zhang, Rongyu, Shi, Hang, Xu, Qihang, Xiao, Longan, Ma, Zhiliang, Agarla, Mirko, Celona, Luigi, Rota, Claudio, Schettini, Raimondo, Huang, Zhiwei, Li, Yanan, Wang, Xiaotao, Lei, Lei, Liu, Hongye, Hong, Wei, Chuang, Ironhead, Lin, Allen, Guan, Drake, Chen, Iris, Lou, Kae, Huang, Willy, Tasi, Yachun, Kao, Yvonne, Fan, Haotian, Kong, Fangyuan, Zhou, Shiqi, Liu, Hao, Lai, Yu, Chen, Shanshan, Wang, Wenqi, Wu, Haoning, Chen, Chaofeng, Zhu, Chunzheng, Guo, Zekun, Zhao, Shiling, Yin, Haibing, Wang, Hongkui, Meftah, Hanene Brachemi, Fezza, Sid Ahmed, Hamidouche, Wassim, Déforges, Olivier, Shi, Tengfei, Mansouri, Azadeh, Motamednia, Hossein, Bakhtiari, Amir Hossein, and Aznaveh, Ahmad Mahmoudi
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Multimedia ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
This paper reports on the NTIRE 2023 Quality Assessment of Video Enhancement Challenge, which will be held in conjunction with the New Trends in Image Restoration and Enhancement Workshop (NTIRE) at CVPR 2023. This challenge is to address a major challenge in the field of video processing, namely, video quality assessment (VQA) for enhanced videos. The challenge uses the VQA Dataset for Perceptual Video Enhancement (VDPVE), which has a total of 1211 enhanced videos, including 600 videos with color, brightness, and contrast enhancements, 310 videos with deblurring, and 301 deshaked videos. The challenge has a total of 167 registered participants. 61 participating teams submitted their prediction results during the development phase, with a total of 3168 submissions. A total of 176 submissions were submitted by 37 participating teams during the final testing phase. Finally, 19 participating teams submitted their models and fact sheets, and detailed the methods they used. Some methods have achieved better results than baseline methods, and the winning methods have demonstrated superior prediction performance.
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- 2023
81. McKean-Vlasov Stochastic Partial Differential Equations: Existence, Uniqueness and Propagation of Chaos
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Hong, Wei, Li, Shihu, and Liu, Wei
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Mathematics - Probability - Abstract
In this paper, we provide a general framework for investigating McKean-Vlasov stochastic partial differential equations. We first show the existence of weak solutions by combining the localizing approximation, Faedo-Galerkin technique, compactness method and the Jakubowski version of the Skorokhod representation theorem. Then under certain locally monotone condition we further investigate the existence and uniqueness of (probabilistically) strong solutions. The applications of the main results include a large class of McKean-Vlasov stochastic partial differential equations such as stochastic 2D/3D Navier-Stokes equations, stochastic Cahn-Hilliard equations and stochastic Kuramoto-Sivashinsky equations. Finally, we show a propagation of chaos result in Wasserstein distance for weakly interacting stochastic 2D Navier-Stokes systems with the interaction term being e.g. {\it{Stokes drag force}} that is proportional to the relative velocity of the particles., Comment: 58 pages
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- 2023
82. CIMulator: A Comprehensive Simulation Platform for Computing-In-Memory Circuit Macros with Low Bit-Width and Real Memory Materials
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Le, Hoang-Hiep, Baig, Md. Aftab, Hong, Wei-Chen, Tsai, Cheng-Hsien, Yeh, Cheng-Jui, Liang, Fu-Xiang, Huang, I-Ting, Tsai, Wei-Tzu, Cheng, Ting-Yin, De, Sourav, Chen, Nan-Yow, Lee, Wen-Jay, Lin, Ing-Chao, Chang, Da-Wei, and Lu, Darsen D.
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Computer Science - Neural and Evolutionary Computing - Abstract
This paper presents a simulation platform, namely CIMulator, for quantifying the efficacy of various synaptic devices in neuromorphic accelerators for different neural network architectures. Nonvolatile memory devices, such as resistive random-access memory, ferroelectric field-effect transistor, and volatile static random-access memory devices, can be selected as synaptic devices. A multilayer perceptron and convolutional neural networks (CNNs), such as LeNet-5, VGG-16, and a custom CNN named C4W-1, are simulated to evaluate the effects of these synaptic devices on the training and inference outcomes. The dataset used in the simulations are MNIST, CIFAR-10, and a white blood cell dataset. By applying batch normalization and appropriate optimizers in the training phase, neuromorphic systems with very low-bit-width or binary weights could achieve high pattern recognition rates that approach software-based CNN accuracy. We also introduce spiking neural networks with RRAM-based synaptic devices for the recognition of MNIST handwritten digits.
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- 2023
83. Multi-Scale McKean-Vlasov SDEs: Moderate Deviation Principle in Different Regimes
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Hong, Wei, Li, Ge, and Li, Shihu
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Mathematics - Probability - Abstract
The main aim of this paper is to study the moderate deviation principle for McKean-Vlasov stochastic differential equations with multiple scales. Specifically, we are interested in the asymptotic estimates of the deviation processes $\frac{X^{\delta}-\bar{X}}{\lambda(\delta)}$ as $\delta\to 0$ in different regimes (i.e. $\varepsilon=o(\delta)$ and $\varepsilon=O(\delta)$), where $\delta$ stands for the intensity of the noise and $\varepsilon:=\varepsilon(\delta)$ stands for the time scale separation. The rate functions in two regimes are different, in particular, we show that it is strongly affected by the noise of the fast component in latter regime, which is essentially different from the former one and the case of large deviations (cf. \cite{HLLS}). As a by-product, the explicit representation formulas of the rate functions in all of regimes are also given. The main techniques are based on the weak convergence approach and the functional occupation measure approach., Comment: 51 pages. To appear in Ann. Inst. Henri Poincar\'e Probab. Stat
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- 2023
84. Novel Cosmological Joint Constraints in Multidimensional Observables Space with Redshift-free Inferences
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Hong, Wei, Jiao, Kang, Wang, Yu-Chen, Zhang, Tingting, and Zhang, Tong-Jie
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Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology - Abstract
Cosmology constraints serve as a crucial criterion in discriminating cosmological models. The traditional combined method to constrain the cosmological parameters designates the corresponding theoretical value and observational data as functions of redshift, however, sometimes the redshift cannot be measured directly, or the measurement error is large, or the definition of redshift is controversial. In this paper, we propose a novel joint method to constrain parameters that eliminates the redshift $z$ and makes full use of the multiple observables $\left\lbrace \mathcal{F}_{1,\mathrm{obs}},\mathcal{F}_{2,\mathrm{obs}},\cdots,\mathcal{F}_{M,\mathrm{obs}}\right\rbrace$ spanning in $M$-dimensional joint observables space. Considering the generality of the mathematical form of the cosmological models and the guidance from low to high dimensions, we firstly validate our method in a three-dimensional joint observables space spanned by $H(z)$, $f\sigma_{8}(z)$ and $D_{A}(z)$, where the three coordinates can be considered redshift-free measurements of the same celestial body (or shared-redshift data reconstructed model independently). Our results are consistent with the traditional combined method but with lower errors, yielding $H_0=68.7\pm0.1\mathrm{~km} \mathrm{~s}^{-1}\mathrm{~Mpc}^{-1}$, $\Omega_{m0}=0.289\pm0.003$, $\sigma_{8}=0.82\pm0.01$ and showing alleviated parametric degeneracies to some extent. In principle, our joint constraint method allows an extended form keeping the redshift information as an independent coordinate and can also be readily degraded to the form of a traditional combined method to constrain parameters., Comment: 20 pages, 15 figures, 4 tables. Accepted for publication in ApJS. Corresponds to version published in ApJS. We propose a new approach to discriminate among concurring cosmological models by adopting classes of cosmological constraints that can maximize the use of the observable space and can allow to eliminate the redshift from the analysis
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- 2023
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85. Diagnosis of Fast Electron Transport by Coherent Transition Radiation
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Liu, Yangchun, Ning, Xiaochuan, Wu, Dong, Liang, Tianyi, Liu, Peng, Liu, Shujun, Liu, Xu, Sheng, Zhengmao, Hong, Wei, Gu, Yuqiu, and He, Xiantu
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Physics - Plasma Physics - Abstract
Transport of fast electron in overdense plasmas is of key importance in high energy density physics. However, it is challenging to diagnose the fast electron transport in experiments. In this article, we study coherent transition radiation (CTR) generated by fast electrons on the back surface of the target by using 2D and 3D first-principle particle-in-cell (PIC) simulations. In our simulations, aluminium target of 2.7 g/cc is simulated in two different situations by using a newly developed high order implicit PIC code. Comparing realistic simulations containing collision and ionization effects, artificial simulations without taking collision and ionization effects into account significantly underestimate the energy loss of electron beam when transporting in the target, which fail to describe the complete characteristics of CTR produced by electron beam on the back surface of the target. Realistic simulations indicate the diameter of CTR increases when the thickness of the target is increased. This is attributed to synergetic energy losses of high flux fast electrons due to Ohm heatings and colliding drags, which appear quite significant even when the thickness of the solid target only differs by micrometers. Especially, when the diagnosing position is fixed, we find that the intensity distribution of the CTR is also a function of time, with the diameter increased with time. As the diameter of CTR is related to the speed of electrons passing through the back surface of the target, our finding may be used as a new tool to diagnose the electron energy spectra near the surface of solid density plasmas., Comment: accepted by New Journal of Physics
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- 2023
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86. Uncommon presentation of acute type A aortic dissection: sleeve-severed and everted proximal right coronary artery intima without myocardial ischaemia
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Huang, Ling-chen, Feng, Zeng-bin, and Guo, Hong-wei
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- 2024
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87. The interaction of oxytocin and nicotine addiction on psychosocial stress: an fMRI study
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Ren, Jiecheng, Zhang, Yuting, Song, Hongwen, Gou, Huixing, Zhao, Qian, Hong, Wei, Piao, Yi, Chen, Yucan, Chen, Yijun, Wen, Shilin, Du, Zhangxin, Li, Chuanfu, Qiu, Bensheng, Ma, Yina, Zhang, Xiaochu, and Wei, Zhengde
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- 2024
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88. Giant retroperitoneal liposarcoma with multiple organ involvement: a case report and literature review
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Sun, Jia-Ning, Yang, Rui, Jiang, Xiao-Lu, Zhang, Feng, and Zhao, Hong-Wei
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- 2024
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89. Reduction of eEF2 kinase alleviates the learning and memory impairment caused by acrylamide
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Wang, Xiao-Li, Zhang, Ru-Nan, Pan, Yu-Lin, Li, Zhi-Ming, Li, Hong-Qiu, Lei, Ya-Ting, Zhao, Fang-Fang, Hao, Xiao-Xiao, Ma, Wei-Wei, Yu, Cui-Ping, Yao, Hong-Wei, Wang, Xin-Yu, Lv, Jun-Jie, Wu, Yong-Hui, and Wang, Sheng-Yuan
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- 2024
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90. Malaysian Medical Students’ Career Intention (MMSCI): a cross-sectional study
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Teng, Zhi Sean, Ser, Gerald Tze Zhen, Hong, Wei-Han, Teo, Chin Hai, Abdul Aziz, Yang Faridah, and Vadivelu, Jamunarani
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- 2024
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91. Targeting mitochondrial quality control: new therapeutic strategies for major diseases
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Hong, Wei-Long, Huang, He, Zeng, Xue, and Duan, Chen-Yang
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- 2024
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92. The interplay between metal ions and immune cells in glioma: pathways to immune escape
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Li, Jin-wei, Mao, Yi-ming, Chen, Shi-liang, Ye, Rui, Fei, Yi-ran, Li, Yue, Tong, Shi-yuan, Yang, Hong-wei, and He, Yi-bo
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- 2024
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93. Prevalence and genotype distribution of human papillomavirus infection among 66000 women from 2014 to 2023 in the plateau region of Southwest China
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Hu, Jian-Peng, Wang, Jun-Ling, Li, Yun, Feng, Yuan, Tian, Can-Qiong, Zhang, Guo-Hui, Chen, Xue-Qin, Liu, Hong-Xia, Yang, Jin-Si, Fang, Zhe-Wei, Li, Yao-Xing, Wu, Zong-Sheng, Zhu, Rui, Li, Xiu-Ping, Xiong, Qian, Gao, Lian-Hao, Ji, Ting, Zhang, Jian-Dong, Song, Jian-Mei, Chen, Qi, Li, Shu-Min, He, Fei, Yang, Chun-Ju, and Li, Hong-Wei
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- 2024
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94. FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis
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Lin, Jing, Lin, Hong-wei, Wang, Yu-xing, Fang, Yan, Jiang, Hui-mian, Li, Ting, Huang, Jia, Zhang, Hua-dong, Chen, Da-zhi, and Chen, Yong-ping
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- 2024
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95. Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis
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Chen, Qing, Yan, Miao, Hu, Annan, Liang, Bing, Lu, Hongwei, Zhou, Lei, Ma, Yiqun, Jia, Chao, Su, Dihan, Kong, Biao, Hong, Wei, Jiang, Libo, and Dong, Jian
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- 2024
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96. The plant-sucking insect selects assembly of the gut microbiota from environment to enhance host reproduction
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Shan, Hong-Wei, Xia, Xie-Jiang, Feng, Yi-Lu, Wu, Wei, Li, Hong-Jie, Sun, Zong-Tao, Li, Jun-Min, and Chen, Jian-Ping
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- 2024
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97. Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats
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Jiang, Qian, Yang, Qifeng, Zhang, Chenting, Hou, Chi, Hong, Wei, Du, Min, Shan, Xiaoqian, Li, Xuanyi, Zhou, Dansha, Wen, Dongmei, Xiong, Yuanhui, Yang, Kai, Lin, Ziying, Song, Jingjing, Mo, Zhanjie, Feng, Huazhuo, Xing, Yue, Fu, Xin, Liu, Chunli, Peng, Fang, Wu, Liling, Li, Bing, Lu, Wenju, Yuan, Jason X.-J., Wang, Jian, and Chen, Yuqin
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- 2024
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98. A multi-classifier system integrated by clinico-histology-genomic analysis for predicting recurrence of papillary renal cell carcinoma
- Author
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Huang, Kang-Bo, Gui, Cheng-Peng, Xu, Yun-Ze, Li, Xue-Song, Zhao, Hong-Wei, Cao, Jia-Zheng, Chen, Yu-Hang, Pan, Yi-Hui, Liao, Bing, Cao, Yun, Zhang, Xin-Ke, Han, Hui, Zhou, Fang-Jian, Liu, Ran-Yi, Chen, Wen-Fang, Jiang, Ze-Ying, Feng, Zi-Hao, Jiang, Fu-Neng, Yu, Yan-Fei, Xiong, Sheng-Wei, Han, Guan-Peng, Tang, Qi, Ouyang, Kui, Qu, Gui-Mei, Wu, Ji-Tao, Cao, Ming, Dong, Bai-Jun, Huang, Yi-Ran, Zhang, Jin, Li, Cai-Xia, Li, Pei-Xing, Chen, Wei, Zhong, Wei-De, Guo, Jian-Ping, Liu, Zhi-Ping, Hsieh, Jer-Tsong, Xie, Dan, Cai, Mu-Yan, Xue, Wei, Wei, Jin-Huan, and Luo, Jun-Hang
- Published
- 2024
- Full Text
- View/download PDF
99. SHR-A1811 (antibody-drug conjugate) in advanced HER2-mutant non-small cell lung cancer: a multicenter, open-label, phase 1/2 study
- Author
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Li, Ziming, Song, Zhengbo, Hong, Wei, Yang, Nong, Wang, Yongsheng, Jian, Hong, Liang, Zibin, Hu, Sheng, Peng, Min, Yu, Yan, Wang, Yan, Jiao, Zicong, Zhao, Kaijing, Song, Ke, Li, You, Shi, Wei, and Lu, Shun
- Published
- 2024
- Full Text
- View/download PDF
100. Investigation on the contaminate of hand washing activities on the surface of environmental objects in intensive care unit
- Author
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Tian, Fang-ying, Wang, Xue-yu, Meng, Hao-peng, Kang, Jian-bang, Zhao, Ming, and Wang, Hong-wei
- Published
- 2024
- Full Text
- View/download PDF
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