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348 results on '"Holm, L.-E"'

56. A multi-disciplinary Danish research programme on rainbow trout (Oncorhynchus mykiss) farming

Author

Berg, P., primary, Eggum, B. O., additional, Møller, S. H., additional, Holm, L.-E., additional, Jørgensen, P. E. V., additional, Olesen, N. J., additional, Buchmann, K., additional, Larsen, J. L., additional, Dalsgaard, I., additional, Mellergaard, S., additional, From, J., additional, Frier, J.-O., additional, McLean, E., additional, Hørlyck, V., additional, Graver, C., additional, Kristensen, T. P., additional, Birk, E., additional, and Bovbjerg, P., additional

Published
1995
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59. Breast cancer

Author

Holm, L-E, primary, Nordevang, E, additional, Auer, G, additional, and Furst, C-J, additional

Published
1991
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60. Cancer Risk After Iodine-131 Therapy for Hyperthyroidism

Author

Holm, L.-E., primary, Hall, P., additional, Wiklund, K., additional, Lundell, G., additional, Berg, G., additional, Bjelkengren, G., additional, Cederquist, E., additional, Ericsson, U.-B., additional, Hallquist, A., additional, Larsson, L.-G., additional, Lidberg, M., additional, Lindberg, S., additional, Tennvall, J., additional, Wicklund, H., additional, and Boice, J. D., additional

Published
1991
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61. Cancer risks in thyroid cancer patients

Author

Hall, P, primary, Holm, L-E, additional, Lundell, G, additional, Bjelkengren, G, additional, Larsson, L-G, additional, Lindberg, S, additional, Tennvall, J, additional, Wicklund, H, additional, and Boice, JD, additional

Published
1991
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74. Combined preoperative radiotherapy and surgery in the treatment of carcinoma of the anterior two-thirds of the tongue.

Author

Holm, Lars-Erik, Lundquist, Per-Gotthard, Bengt-Inge Rudén, Silfverswärd, Claes, Sobin, Aron, Wersäll, Jan, Holm, L E, Lundquist, P G, Rudén, B I, Silfverswärd, C, Sobin, A, and Wersäll, J

Subjects
PREOPERATIVE care, RESEARCH, TONGUE tumors, RESEARCH methodology, METASTASIS, PROGNOSIS, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, RADIATION doses, SQUAMOUS cell carcinoma
Abstract

Sixty-three patients with squamous cell carcinoma of the anterior two-thirds of the tongue were treated with preoperative external radiotherapy (mean target dose 42.60 Gray or 4260 rad) and surgery. The expected 5-year survival, expressed as life table estimate of percent of survivors, was 77% for patients with Stage I tumors, 69% with Stage II, and 13% for patients with tumors in Stages III-IV (p less than 0.001). Fourteen patients experienced local recurrences, 7 had homolateral neck metastases, 4 had contralateral neck metastases and 3 had distant metastases. In 15 cases no cancer could be detected at review of the surgical specimens, but 2 of these died of their cancers. In 43 cases cancer was present in the specimens, and 26 of these died of their cancer (p less than 0.01). [ABSTRACT FROM AUTHOR]

Published
1983
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76. Genome-wide association study using high-density single nucleotide polymorphism arrays and whole-genome sequences for clinical mastitis traits in dairy cattle1

Author

Sahana, G., Guldbrandtsen, B., Thomsen, B., Holm, L-E., Panitz, F., Brøndum, R.F., Bendixen, C., and Lund, M.S.

Subjects
quantitative trait locus, NGS, dairy cattle, mastitis
Abstract

Mastitis is a mammary disease that frequently affects dairy cattle. Despite considerable research on the development of effective prevention and treatment strategies, mastitis continues to be a significant issue in bovine veterinary medicine. To identify major genes that affect mastitis in dairy cattle, 6 chromosomal regions on Bos taurus autosome (BTA) 6, 13, 16, 19, and 20 were selected from a genome scan for 9 mastitis phenotypes using imputed high-density single nucleotide polymorphism arrays. Association analyses using sequence-level variants for the 6 targeted regions were carried out to map causal variants using whole-genome sequence data from 3 breeds. The quantitative trait loci (QTL) discovery population comprised 4,992 progeny-tested Holstein bulls, and QTL were confirmed in 4,442 Nordic Red and 1,126 Jersey cattle. The targeted regions were imputed to the sequence level. The highest association signal for clinical mastitis was observed on BTA 6 at 88.97 Mb in Holstein cattle and was confirmed in Nordic Red cattle. The peak association region on BTA 6 contained 2 genes: vitamin D-binding protein precursor (GC) and neuropeptide FF receptor 2 (NPFFR2), which, based on known biological functions, are good candidates for affecting mastitis. However, strong linkage disequilibrium in this region prevented conclusive determination of the causal gene. A different QTL on BTA 6 located at 88.32 Mb in Holstein cattle affected mastitis. In addition, QTL on BTA 13 and 19 were confirmed to segregate in Nordic Red cattle and QTL on BTA 16 and 20 were confirmed in Jersey cattle. Although several candidate genes were identified in these targeted regions, it was not possible to identify a gene or polymorphism as the causal factor for any of these regions.

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78. Breast Hypoplasia Following Irradiation of the Female Breast in Infancy and Early Childhood

Author

Fürst, C. J., Lundell, M., Ahlbäck, S. O., and Holm, L. E.

Abstract

The occurrence and the degree of breast hypoplasia were studied in 129 women irradiated with ionizing radiation in infancy or childhood for hemangioma located in the breast region. the patients were born between 1934 and 1943 and were treated at Radiumhemmet before 4 years of age. Dosimetry was based on treatment data. the mean absorbed dose to the breast anlage was 2.3 Gy. Breast asymmetry was estimated by a mailed questionnaire to all patients and by a clinical examination of 53 patients living in Stockholm County. Breast hypoplasia on the treated side was reported by 57% of the patients and on the contralateral side by 8%. A breast hypoplasia exceeding 10% was found in 53 % of the clinically examined patients on the treated side and in 9% on the contralateral side. the frequency and the severity of impaired breast development increased with the absorbed dose. the possibility of a threshold dose for the occurrence of breast hypoplasia could neither be established nor ruled out.

Published
1989
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79. Cancer risks in Swedish Lapps who breed reindeer.

Author

Wiklund, K, Holm, L E, and Eklund, G

Abstract

Cancer risks during the period 1961-1984 were studied in a cohort of 2,034 Swedish reindeer-breeding Lapps, a unique group whose culture and life-style differ considerably from those in the rest of the Swedish population. A total of 100 cases of cancer were observed versus 163 expected. Statistically significantly decreased risks were found for cancers of the colon, respiratory organs, female breast, male genital organs, and kidneys, and for malignant lymphomas. The stomach was the only site with a significantly increased risk. Reindeer-breeding Lapps have ingested fallout products via the lichen-reindeer-man food chain since the 1950s. However, no increased risk was found for the cancer sites considered to be most sensitive to radiation.

Published
1990
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91. Response

Author

HOLM, L.-E., primary, WIKLUND, K., additional, and LUNDELL, G., additional

Published
1989
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96. Cancer Risk in Population Examined With Diagnostic Doses of 131I

Author

Holm, L.-E., primary, Wiklund, K. E., additional, Lundell, G. E., additional, Bergman, N. A., additional, Bjelkengren, G., additional, Ericsson, U.-B. C., additional, Cederquist, E. S., additional, Lindberg, R. S., additional, Wicklund, H. V., additional, Boice, J. D., additional, and Lidberg, M. E., additional

Published
1989
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