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53. Genetic variants associated with longitudinal changes in brain structure across the lifespan

Author

Brouwer, Rachel M., Klein, Marieke, Grasby, Katrina L., Schnack, Hugo G., Jahanshad, Neda, Teeuw, Jalmar, Thomopoulos, Sophia I., Sprooten, Emma, Franz, Carol E., Gogtay, Nitin, Kremen, William S., Panizzon, Matthew S., Olde Loohuis, Loes M., Whelan, Christopher D., Aghajani, Moji, Alloza, Clara, Alnæs, Dag, Artiges, Eric, Ayesa-Arriola, Rosa, Barker, Gareth J., Bastin, Mark E., Blok, Elisabet, Bøen, Erlend, Breukelaar, Isabella A., Bright, Joanna K., Buimer, Elizabeth E. L., Bülow, Robin, Cannon, Dara M., Ciufolini, Simone, Crossley, Nicolas A., Damatac, Christienne G., Dazzan, Paola, de Mol, Casper L., de Zwarte, Sonja M. C., Desrivières, Sylvane, Díaz-Caneja, Covadonga M., Doan, Nhat Trung, Dohm, Katharina, Fröhner, Juliane H., Goltermann, Janik, Grigis, Antoine, Grotegerd, Dominik, Han, Laura K. M., Harris, Mathew A., Hartman, Catharina A., Heany, Sarah J., Heindel, Walter, Heslenfeld, Dirk J., Hohmann, Sarah, Ittermann, Bernd, Jansen, Philip R., Janssen, Joost, Jia, Tianye, Jiang, Jiyang, Jockwitz, Christiane, Karali, Temmuz, Keeser, Daniel, Koevoets, Martijn G. J. C., Lenroot, Rhoshel K., Malchow, Berend, Mandl, René C. W., Medel, Vicente, Meinert, Susanne, Morgan, Catherine A., Mühleisen, Thomas W., Nabulsi, Leila, Opel, Nils, de la Foz, Víctor Ortiz-García, Overs, Bronwyn J., Paillère Martinot, Marie-Laure, Redlich, Ronny, Marques, Tiago Reis, Repple, Jonathan, Roberts, Gloria, Roshchupkin, Gennady V., Setiaman, Nikita, Shumskaya, Elena, Stein, Frederike, Sudre, Gustavo, Takahashi, Shun, Thalamuthu, Anbupalam, Tordesillas-Gutiérrez, Diana, van der Lugt, Aad, van Haren, Neeltje E. M., Wardlaw, Joanna M., Wen, Wei, Westeneng, Henk-Jan, Wittfeld, Katharina, Zhu, Alyssa H., Zugman, Andre, Armstrong, Nicola J., Bonfiglio, Gaia, Bralten, Janita, Dalvie, Shareefa, Davies, Gail, Di Forti, Marta, Ding, Linda, Donohoe, Gary, Forstner, Andreas J., Gonzalez-Peñas, Javier, Guimaraes, Joao P. O. F. T., Homuth, Georg, Hottenga, Jouke-Jan, Knol, Maria J., Kwok, John B. J., Le Hellard, Stephanie, Mather, Karen A., Milaneschi, Yuri, Morris, Derek W., Nöthen, Markus M., Papiol, Sergi, Rietschel, Marcella, Santoro, Marcos L., Steen, Vidar M., Stein, Jason L., Streit, Fabian, Tankard, Rick M., Teumer, Alexander, van ‘t Ent, Dennis, van der Meer, Dennis, van Eijk, Kristel R., Vassos, Evangelos, Vázquez-Bourgon, Javier, Witt, Stephanie H., Adams, Hieab H. H., Agartz, Ingrid, Ames, David, Amunts, Katrin, Andreassen, Ole A., Arango, Celso, Banaschewski, Tobias, Baune, Bernhard T., Belangero, Sintia I., Bokde, Arun L. W., Boomsma, Dorret I., Bressan, Rodrigo A., Brodaty, Henry, Buitelaar, Jan K., Cahn, Wiepke, Caspers, Svenja, Cichon, Sven, Crespo-Facorro, Benedicto, Cox, Simon R., Dannlowski, Udo, Elvsåshagen, Torbjørn, Espeseth, Thomas, Falkai, Peter G., Fisher, Simon E., Flor, Herta, Fullerton, Janice M., Garavan, Hugh, Gowland, Penny A., Grabe, Hans J., Hahn, Tim, Heinz, Andreas, Hillegers, Manon, Hoare, Jacqueline, Hoekstra, Pieter J., Ikram, Mohammad A., Jackowski, Andrea P., Jansen, Andreas, Jönsson, Erik G., Kahn, Rene S., Kircher, Tilo, Korgaonkar, Mayuresh S., Krug, Axel, Lemaitre, Herve, Malt, Ulrik F., Martinot, Jean-Luc, McDonald, Colm, Mitchell, Philip B., Muetzel, Ryan L., Murray, Robin M., Nees, Frauke, Nenadić, Igor, Oosterlaan, Jaap, Ophoff, Roel A., Pan, Pedro M., Penninx, Brenda W. J. H., Poustka, Luise, Sachdev, Perminder S., Salum, Giovanni A., Schofield, Peter R., Schumann, Gunter, Shaw, Philip, Sim, Kang, Smolka, Michael N., Stein, Dan J., Trollor, Julian N., van den Berg, Leonard H., Veldink, Jan H., Walter, Henrik, Westlye, Lars T., Whelan, Robert, White, Tonya, Wright, Margaret J., Medland, Sarah E., Franke, Barbara, Thompson, Paul M., and Hulshoff Pol, Hilleke E.

Published
2022
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55. Interrogating the Genetic Determinants of Tourette’s Syndrome and Other Tic Disorders Through Genome-Wide Association Studies

Author

Yu, Dongmei, Sul, Jae Hoon, Tsetsos, Fotis, Nawaz, Muhammad S, Huang, Alden Y, Zelaya, Ivette, Illmann, Cornelia, Osiecki, Lisa, Darrow, Sabrina M, Hirschtritt, Matthew E, Greenberg, Erica, Muller-Vahl, Kirsten R, Stuhrmann, Manfred, Dion, Yves, Rouleau, Guy, Aschauer, Harald, Stamenkovic, Mara, Schlögelhofer, Monika, Sandor, Paul, Barr, Cathy L, Grados, Marco, Singer, Harvey S, Nöthen, Markus M, Hebebrand, Johannes, Hinney, Anke, King, Robert A, Fernandez, Thomas V, Barta, Csaba, Tarnok, Zsanett, Nagy, Peter, Depienne, Christel, Worbe, Yulia, Hartmann, Andreas, Budman, Cathy L, Rizzo, Renata, Lyon, Gholson J, McMahon, William M, Batterson, James R, Cath, Danielle C, Malaty, Irene A, Okun, Michael S, Berlin, Cheston, Woods, Douglas W, Lee, Paul C, Jankovic, Joseph, Robertson, Mary M, Gilbert, Donald L, Brown, Lawrence W, Coffey, Barbara J, Dietrich, Andrea, Hoekstra, Pieter J, Kuperman, Samuel, Zinner, Samuel H, Luðvigsson, Pétur, Sæmundsen, Evald, Thorarensen, Ólafur, Atzmon, Gil, Barzilai, Nir, Wagner, Michael, Moessner, Rainald, Ophoff, Roel, Pato, Carlos N, Pato, Michele T, Knowles, James A, Roffman, Joshua L, Smoller, Jordan W, Buckner, Randy L, Willsey, A Jeremy, Tischfield, Jay A, Heiman, Gary A, Stefansson, Hreinn, Stefansson, Kári, Posthuma, Danielle, Cox, Nancy J, Pauls, David L, Freimer, Nelson B, Neale, Benjamin M, Davis, Lea K, Paschou, Peristera, Coppola, Giovanni, Mathews, Carol A, and Scharf, Jeremiah M

Subjects
Mental Health, Prevention, Brain Disorders, Human Genome, Neurosciences, Neurodegenerative, Serious Mental Illness, Tourette Syndrome, Genetics, Aetiology, 2.1 Biological and endogenous factors, Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Risk Factors, Severity of Illness Index, Tic Disorders, fms-Like Tyrosine Kinase 3, Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group, Child Psychiatry, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

ObjectiveTourette's syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette's syndrome and other tic disorders. The authors conducted a GWAS meta-analysis and probed aggregated Tourette's syndrome polygenic risk to test whether Tourette's and related tic disorders have an underlying shared genetic etiology and whether Tourette's polygenic risk scores correlate with worst-ever tic severity and may represent a potential predictor of disease severity.MethodsGWAS meta-analysis, gene-based association, and genetic enrichment analyses were conducted in 4,819 Tourette's syndrome case subjects and 9,488 control subjects. Replication of top loci was conducted in an independent population-based sample (706 case subjects, 6,068 control subjects). Relationships between Tourette's polygenic risk scores (PRSs), other tic disorders, ascertainment, and tic severity were examined.ResultsGWAS and gene-based analyses identified one genome-wide significant locus within FLT3 on chromosome 13, rs2504235, although this association was not replicated in the population-based sample. Genetic variants spanning evolutionarily conserved regions significantly explained 92.4% of Tourette's syndrome heritability. Tourette's-associated genes were significantly preferentially expressed in dorsolateral prefrontal cortex. Tourette's PRS significantly predicted both Tourette's syndrome and tic spectrum disorders status in the population-based sample. Tourette's PRS also significantly correlated with worst-ever tic severity and was higher in case subjects with a family history of tics than in simplex case subjects.ConclusionsModulation of gene expression through noncoding variants, particularly within cortico-striatal circuits, is implicated as a fundamental mechanism in Tourette's syndrome pathogenesis. At a genetic level, tic disorders represent a continuous spectrum of disease, supporting the unification of Tourette's syndrome and other tic disorders in future diagnostic schemata. Tourette's PRSs derived from sufficiently large samples may be useful in the future for predicting conversion of transient tics to chronic tic disorders, as well as tic persistence and lifetime tic severity.

Published
2019

59. European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part III: pharmacological treatment

Author

Roessner, Veit, Eichele, Heike, Stern, Jeremy S., Skov, Liselotte, Rizzo, Renata, Debes, Nanette Mol, Nagy, Péter, Cavanna, Andrea E., Termine, Cristiano, Ganos, Christos, Münchau, Alexander, Szejko, Natalia, Cath, Danielle, Müller-Vahl, Kirsten R., Verdellen, Cara, Hartmann, Andreas, Rothenberger, Aribert, Hoekstra, Pieter J., and Plessen, Kerstin J.

Published
2022
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61. Subgrouping children and adolescents with disruptive behaviors: symptom profiles and the role of callous–unemotional traits

Author

Rosa-Justicia, Mireia, Saam, Melanie C., Flamarique, Itziar, Borràs, Roger, Naaijen, Jilly, Dietrich, Andrea, Hoekstra, Pieter J., Banaschewski, Tobias, Aggensteiner, Pascal, Craig, Michael C., Sethi, Arjun, Santosh, Paramala, Sagar-Ouriaghli, Ilyas, Arango, Celso, Penzol, María José, Brandeis, Daniel, Werhahn, Julia E., Glennon, Jeffrey C., Franke, Barbara, Zwiers, Marcel P., Buitelaar, Jan K., Schulze, Ulrike M. E., and Castro-Fornieles, Josefina

Published
2022
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62. Psychopharmacology in children and adolescents:unmet needs and opportunities

Author

Cortese, Samuele, Purper-Ouakil, Diane, Apter, Alan, Arango, Celso, Baeza, Inmaculada, Banaschewski, Tobias, Buitelaar, Jan, Castro-Fornieles, Josefina, Coghill, David, Cohen, David, Correll, Christoph U., Grünblatt, Edna, Hoekstra, Pieter J., James, Anthony, Jeppesen, Pia, Nagy, Péter, Pagsberg, Anne Katrine, Parellada, Mara, Persico, Antonio M., Roessner, Veit, Santosh, Paramala, Simonoff, Emily, Stevanovic, Dejan, Stringaris, Argyris, Vitiello, Benedetto, Walitza, Susanne, Weizman, Abraham, Wong, Ian C.K., Zalsman, Gil, Zuddas, Alessandro, Carucci, Sara, Butlen-Ducuing, Florence, Tome, Maria, Bea, Myriam, Getin, Christine, Hovén, Nina, Konradsson-Geuken, Asa, Lamirell, Daphne, Olisa, Nigel, Nafria Escalera, Begonya, Moreno, Carmen, Cortese, Samuele, Purper-Ouakil, Diane, Apter, Alan, Arango, Celso, Baeza, Inmaculada, Banaschewski, Tobias, Buitelaar, Jan, Castro-Fornieles, Josefina, Coghill, David, Cohen, David, Correll, Christoph U., Grünblatt, Edna, Hoekstra, Pieter J., James, Anthony, Jeppesen, Pia, Nagy, Péter, Pagsberg, Anne Katrine, Parellada, Mara, Persico, Antonio M., Roessner, Veit, Santosh, Paramala, Simonoff, Emily, Stevanovic, Dejan, Stringaris, Argyris, Vitiello, Benedetto, Walitza, Susanne, Weizman, Abraham, Wong, Ian C.K., Zalsman, Gil, Zuddas, Alessandro, Carucci, Sara, Butlen-Ducuing, Florence, Tome, Maria, Bea, Myriam, Getin, Christine, Hovén, Nina, Konradsson-Geuken, Asa, Lamirell, Daphne, Olisa, Nigel, Nafria Escalera, Begonya, and Moreno, Carmen

Abstract

Psychopharmacological treatment is an important component of the multimodal intervention approach to treating mental health conditions in children and adolescents. Currently, there are many unmet needs but also opportunities, alongside possible risks to consider, regarding the pharmacological treatment of mental health conditions in children and adolescents. In this Position Paper, we highlight and address these unmet needs and opportunities, including the perspectives of clinicians and researchers from the European College of Neuropsychopharmacology–Child and Adolescent Network, alongside those of experts by lived experience from national and international associations, via a survey involving 644 participants from 13 countries, and of regulators, through representation from the European Medicines Agency. We present and discuss the evidence base for medications currently used for mental disorders in children and adolescents, medications in the pipeline, opportunities in the development of novel medications, crucial priorities for the conduct of future clinical studies, challenges and opportunities in terms of the regulatory and legislative framework, and innovations in the way research is conducted, reported, and promoted.

Published
2024

64. An Individual Participant Data Meta-analysis: Behavioral Treatments for Children and Adolescents With Attention-Deficit/Hyperactivity Disorder

Author

Groenman, Annabeth P., Hornstra, Rianne, Hoekstra, Pieter J., Steenhuis, Laura, Aghebati, Asma, Boyer, Bianca E., Buitelaar, Jan K., Chronis-Tuscano, Andrea, Daley, David, Dehkordian, Parisa, Dvorsky, Melissa, Franke, Nike, DuPaul, George J., Gershy, Naama, Harvey, Elizabeth, Hennig, Timo, Herbert, Sharonne, Langberg, Joshua, Mautone, Jennifer A., Mikami, Amori Yee, Pfiffner, Linda J., Power, Thomas J., Reijneveld, Sijmen A., Schramm, Satyam Antonio, Schweitzer, Julie B., Sibley, Margaret H., Sonuga-Barke, Edmund, Thompson, Catharine, Thompson, Margaret, Webster-Stratton, Carolyn, Xie, Yuhuan, Luman, Marjolein, van der Oord, Saskia, and van den Hoofdakker, Barbara J.

Published
2022
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66. Optimizing and Predicting Antidepressant Efficacy in Patients with Major Depressive Disorder Using Multi-Omics Analysis and the Opade AI Prediction Tools.

Author

Corrivetti, Giulio, Monaco, Francesco, Vignapiano, Annarita, Marenna, Alessandra, Palm, Kaia, Fernández-Arroyo, Salvador, Frigola-Capell, Eva, Leen, Volker, Ibarrola, Oihane, Amil, Burak, Caruson, Mattia Marco, Chiariotti, Lorenzo, Palacios-Ariza, Maria Alejandra, Hoekstra, Pieter J., Chiang, Hsin-Yin, Floareș, Alexandru, Fagiolini, Andrea, and Fasano, Alessio

Subjects
MENTAL depression, PATIENT participation, CHATBOTS, ARTIFICIAL intelligence, GENETICS
Abstract

According to the World Health Organization (WHO), major depressive disorder (MDD) is the fourth leading cause of disability worldwide and the second most common disease after cardiovascular events. Approximately 280 million people live with MDD, with incidence varying by age and gender (female to male ratio of approximately 2:1). Although a variety of antidepressants are available for the different forms of MDD, there is still a high degree of individual variability in response and tolerability. Given the complexity and clinical heterogeneity of these disorders, a shift from "canonical treatment" to personalized medicine with improved patient stratification is needed. OPADE is a non-profit study that researches biomarkers in MDD to tailor personalized drug treatments, integrating genetics, epigenetics, microbiome, immune response, and clinical data for analysis. A total of 350 patients between 14 and 50 years will be recruited in 6 Countries (Italy, Colombia, Spain, The Netherlands, Turkey) for 24 months. Real-time electroencephalogram (EEG) and patient cognitive assessment will be correlated with biological sample analysis. A patient empowerment tool will be deployed to ensure patient commitment and to translate patient stories into data. The resulting data will be used to train the artificial intelligence/machine learning (AI/ML) predictive tool. [ABSTRACT FROM AUTHOR]

Published
2024
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69. Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach

Author

Abdulkadir, Mohamed, Londono, Douglas, Gordon, Derek, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, Elzerman, Lonneke, Fremer, Carolin, Fründt, Odette, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Jakubovski, Ewgeni, Kim, Young Key, Kim, Young Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Mir, Pablo, Morer, Astrid, Müller-Vahl, Kirsten, Münchau, Alexander, Murphy, Tara L, Plessen, Kerstin J, Roessner, Veit, Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, King, Robert A, Tischfield, Jay A, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Brain Disorders, Autism, Genetics, Pediatric, Mental Health, Intellectual and Developmental Disabilities (IDD), Tourette Syndrome, Neurodegenerative, Human Genome, 2.1 Biological and endogenous factors, Aetiology, Mental health, Adolescent, Adult, Child, Child, Preschool, Family Health, Female, Genome-Wide Association Study, Genotype, Humans, Linkage Disequilibrium, Male, Microtubule-Associated Proteins, Middle Aged, Polymorphism, Single Nucleotide, Severity of Illness Index, Tic Disorders, Tryptophan Hydroxylase, Young Adult, Attention-deficit/hyperactivity disorder, Candidate gene study, Obsessive-compulsive disorder, Tourette syndrome, Transmission Disequilibrium Test, Obsessive–compulsive disorder, Cognitive Sciences, Psychiatry, Clinical sciences, Biological psychology
Abstract

Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent-child trios; 117 additional SNPs in 211 trios; and 4 additional SNPs in 254 trios. We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case-control cohort. After quality control 71 SNPs were available in 371 trios; 112 SNPs in 179 trios; and 3 SNPs in 192 trios. 17 were candidate SNPs implicated in TS and 2 were implicated in obsessive-compulsive disorder (OCD) or autism spectrum disorder (ASD); 142 were tagging SNPs from eight monoamine neurotransmitter-related genes (including dopamine and serotonin); 10 were top SNPs from TS GWAS; and 13 top SNPs from attention-deficit/hyperactivity disorder, OCD, or ASD GWAS. None of the SNPs or genes reached significance after adjustment for multiple testing. We observed nominal significance for the candidate SNPs rs3744161 (TBCD) and rs4565946 (TPH2) and for five tagging SNPs; none of these showed significance in the independent cohort. Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM). We found no convincing support for previously implicated genetic polymorphisms. Targeted re-sequencing should fully appreciate the relevance of candidate genes.

Published
2018

70. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Author

Guadalupe, Tulio, Mathias, Samuel R, vanErp, Theo GM, Whelan, Christopher D, Zwiers, Marcel P, Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A, Arias-Vásquez, Alejandro, Aribisala, Benjamin S, Armstrong, Nicola J, Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G, Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E, Baune, Bernhard T, Blangero, John, Bokde, Arun LW, Boedhoe, Premika SW, Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D, Cannon, Dara M, Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J, Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I, de Zwarte, Sonja MC, Deary, Ian J, Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S, Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean-Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J, Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U, Heinz, Andreas, Hibar, Derrek P, Hoekstra, Pieter J, Hoogman, Martine, Howells, Fleur M, Hu, Hao, Hulshoff Pol, Hilleke E, Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G, Jurk, Sarah, Kahn, Rene S, Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus-Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Martinot, Jean-Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L, Medland, Sarah E, Menchón, José M, Morris, Derek W, Mothersill, Omar, Maniega, Susana Munoz, and Mwangi, Benson

Subjects
Brain, Humans, Magnetic Resonance Imaging, Organ Size, Aging, Sex Characteristics, Quantitative Trait, Heritable, Adolescent, Adult, Aged, Middle Aged, Female, Male, Functional Laterality, Meta-Analysis as Topic, Young Adult, Age, Enigma, Handedness, Heritability, Meta-analysis, Sex, Subcortical brain asymmetry, Quantitative Trait, Heritable, Medical and Health Sciences, Psychology and Cognitive Sciences, Experimental Psychology
Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

Published
2017

72. The Short- and Longer-Term Effects of Brief Behavioral Parent Training Versus Care as Usual in Children with Behavioral Difficulties: Study Protocol for a Randomized Controlled Trial

Author

Doornik, Roos S. van, primary, Oord, Saskia van der, additional, Luijckx, Joli, additional, Groenman, Annabeth P., additional, Leijten, Patty, additional, Luman, Marjolein, additional, Hoekstra, Pieter J., additional, Hoofdakker, Barbara J. van den, additional, and Dekkers, Tycho J., additional

Published
2024
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75. The World Federation of ADHD International Consensus Statement: 208 Evidence-based conclusions about the disorder

Author

Faraone, Stephen V., Banaschewski, Tobias, Coghill, David, Zheng, Yi, Biederman, Joseph, Bellgrove, Mark A., Newcorn, Jeffrey H., Gignac, Martin, Al Saud, Nouf M., Manor, Iris, Rohde, Luis Augusto, Yang, Li, Cortese, Samuele, Almagor, Doron, Stein, Mark A., Albatti, Turki H., Aljoudi, Haya F., Alqahtani, Mohammed M.J., Asherson, Philip, Atwoli, Lukoye, Bölte, Sven, Buitelaar, Jan K., Crunelle, Cleo L., Daley, David, Dalsgaard, Søren, Döpfner, Manfred, Espinet (on behalf of CADDRA), Stacey, Fitzgerald, Michael, Franke, Barbara, Gerlach, Manfred, Haavik, Jan, Hartman, Catharina A., Hartung, Cynthia M., Hinshaw, Stephen P., Hoekstra, Pieter J., Hollis, Chris, Kollins, Scott H., Sandra Kooij, J.J., Kuntsi, Jonna, Larsson, Henrik, Li, Tingyu, Liu, Jing, Merzon, Eugene, Mattingly, Gregory, Mattos, Paulo, McCarthy, Suzanne, Mikami, Amori Yee, Molina, Brooke S.G., Nigg, Joel T., Purper-Ouakil, Diane, Omigbodun, Olayinka O., Polanczyk, Guilherme V., Pollak, Yehuda, Poulton, Alison S., Rajkumar, Ravi Philip, Reding, Andrew, Reif, Andreas, Rubia, Katya, Rucklidge, Julia, Romanos, Marcel, Ramos-Quiroga, J. Antoni, Schellekens, Arnt, Scheres, Anouk, Schoeman, Renata, Schweitzer, Julie B., Shah, Henal, Solanto, Mary V., Sonuga-Barke, Edmund, Soutullo, César, Steinhausen, Hans-Christoph, Swanson, James M., Thapar, Anita, Tripp, Gail, van de Glind, Geurt, van den Brink, Wim, Van der Oord, Saskia, Venter, Andre, Vitiello, Benedetto, Walitza, Susanne, and Wang, Yufeng

Published
2021
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77. Aggression subtypes relate to distinct resting state functional connectivity in children and adolescents with disruptive behavior

Author

Werhahn, Julia E., Mohl, Susanna, Willinger, David, Smigielski, Lukasz, Roth, Alexander, Hofstetter, Christoph, Stämpfli, Philipp, Naaijen, Jilly, Mulder, Leandra M., Glennon, Jeffrey C., Hoekstra, Pieter J., Dietrich, Andrea, Kleine Deters, Renee, Aggensteiner, Pascal M., Holz, Nathalie E., Baumeister, Sarah, Banaschewski, Tobias, Saam, Melanie C., Schulze, Ulrike M. E., Lythgoe, David J., Sethi, Arjun, Craig, Michael C., Mastroianni, Mathilde, Sagar-Ouriaghli, Ilyas, Santosh, Paramala J., Rosa, Mireia, Bargallo, Nuria, Castro-Fornieles, Josefina, Arango, Celso, Penzol, Maria J., Zwiers, Marcel P., Franke, Barbara, Buitelaar, Jan K., Walitza, Susanne, and Brandeis, Daniel

Published
2021
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78. Reward and Punishment Sensitivity are Associated with Cross-disorder Traits

Author

Portengen, Christel M., Sprooten, Emma, Zwiers, Marcel P., Hoekstra, Pieter J., Dietrich, Andrea, Holz, Nathalie E., Aggensteiner, Pascal M., Banaschewski, Tobias, Schulze, Ulrike M.E., Saam, Melanie C., Craig, Michael C., Sethi, Arjun, Santosh, Paramala, Ouriaghli, Ilyas Sagar, Castro-Fornieles, Josefina, Rosa, Mireia, Arango, Celso, Penzol, María José, Werhahn, Julia E., Brandeis, Daniel, Walitza, Susanne, Oldehinkel, Marianne, Franke, Barbara, Buitelaar, Jan K., and Naaijen, Jilly

Published
2021
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79. Application of Latent Class Analysis to Identify Subgroups of Children with Autism Spectrum Disorders who Benefit from Social Skills Training

Author

Dekker, Vera, Nauta, Maaike H., Timmerman, Marieke E., Mulder, Erik J., Hoekstra, Pieter J., and de Bildt, Annelies

Subjects
Social skills in children -- Training, Autistic children -- Social aspects -- Training -- Identification and classification, Health
Abstract

With Latent Class Analysis applied on data of 98 children with autism spectrum disorder (ASD) (9-12 years; 17 girls) participating in social skills training (SST) in a randomized controlled trial (Dekker et al. 2019), four subgroups were detected, based on social-communicative skills before, and response patterns to training. Two subgroups improved after SST. Characterizing the subgroups based on participant and intervention characteristics showed that improvement was related to lower parent-reported perceived difficulty of social-communicative skills at start, higher verbal ability, younger age and milder symptoms of ASD and anxiety. The lowest performing non-improving subgroup participated more often in SST without parent/teacher involvement, compared to all other subgroups. Response to SST in ASD seems to vary depending on participant characteristics., Author(s): Vera Dekker [sup.1] [sup.2] , Maaike H. Nauta [sup.2] [sup.3] , Marieke E. Timmerman [sup.4] , Erik J. Mulder [sup.5] , Pieter J. Hoekstra [sup.1] [sup.2] , Annelies de [...]

Published
2021
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81. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis

Author

Hoogman, Martine, Bralten, Janita, Hibar, Derrek P, Mennes, Maarten, Zwiers, Marcel P, Schweren, Lizanne SJ, van Hulzen, Kimm JE, Medland, Sarah E, Shumskaya, Elena, Jahanshad, Neda, de Zeeuw, Patrick, Szekely, Eszter, Sudre, Gustavo, Wolfers, Thomas, Onnink, Alberdingk MH, Dammers, Janneke T, Mostert, Jeanette C, Vives-Gilabert, Yolanda, Kohls, Gregor, Oberwelland, Eileen, Seitz, Jochen, Schulte-Rüther, Martin, Ambrosino, Sara, Doyle, Alysa E, Høvik, Marie F, Dramsdahl, Margaretha, Tamm, Leanne, van Erp, Theo GM, Dale, Anders, Schork, Andrew, Conzelmann, Annette, Zierhut, Kathrin, Baur, Ramona, McCarthy, Hazel, Yoncheva, Yuliya N, Cubillo, Ana, Chantiluke, Kaylita, Mehta, Mitul A, Paloyelis, Yannis, Hohmann, Sarah, Baumeister, Sarah, Bramati, Ivanei, Mattos, Paulo, Tovar-Moll, Fernanda, Douglas, Pamela, Banaschewski, Tobias, Brandeis, Daniel, Kuntsi, Jonna, Asherson, Philip, Rubia, Katya, Kelly, Clare, Di Martino, Adriana, Milham, Michael P, Castellanos, Francisco X, Frodl, Thomas, Zentis, Mariam, Lesch, Klaus-Peter, Reif, Andreas, Pauli, Paul, Jernigan, Terry L, Haavik, Jan, Plessen, Kerstin J, Lundervold, Astri J, Hugdahl, Kenneth, Seidman, Larry J, Biederman, Joseph, Rommelse, Nanda, Heslenfeld, Dirk J, Hartman, Catharina A, Hoekstra, Pieter J, Oosterlaan, Jaap, von Polier, Georg, Konrad, Kerstin, Vilarroya, Oscar, Ramos-Quiroga, Josep Antoni, Soliva, Joan Carles, Durston, Sarah, Buitelaar, Jan K, Faraone, Stephen V, Shaw, Philip, Thompson, Paul M, and Franke, Barbara

Subjects
Brain Disorders, Neurosciences, Attention Deficit Hyperactivity Disorder (ADHD), Clinical Research, Mental Health, Pediatric, Biomedical Imaging, 2.1 Biological and endogenous factors, Aetiology, Mental health, Good Health and Well Being, Adolescent, Adult, Attention Deficit Disorder with Hyperactivity, Brain, Case-Control Studies, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Linear Models, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Young Adult, Clinical Sciences, Public Health and Health Services, Psychology
Abstract

BackgroundNeuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to investigate whether there are structural differences in children and adults with ADHD compared with those without this diagnosis.MethodsIn this cross-sectional mega-analysis, we used the data from the international ENIGMA Working Group collaboration, which in the present analysis was frozen at Feb 8, 2015. Individual sites analysed structural T1-weighted MRI brain scans with harmonised protocols of individuals with ADHD compared with those who do not have this diagnosis. Our primary outcome was to assess case-control differences in subcortical structures and intracranial volume through pooling of all individual data from all cohorts in this collaboration. For this analysis, p values were significant at the false discovery rate corrected threshold of p=0·0156.FindingsOur sample comprised 1713 participants with ADHD and 1529 controls from 23 sites with a median age of 14 years (range 4-63 years). The volumes of the accumbens (Cohen's d=-0·15), amygdala (d=-0·19), caudate (d=-0·11), hippocampus (d=-0·11), putamen (d=-0·14), and intracranial volume (d=-0·10) were smaller in individuals with ADHD compared with controls in the mega-analysis. There was no difference in volume size in the pallidum (p=0·95) and thalamus (p=0·39) between people with ADHD and controls. Exploratory lifespan modelling suggested a delay of maturation and a delay of degeneration, as effect sizes were highest in most subgroups of children (21 years): in the accumbens (Cohen's d=-0·19 vs -0·10), amygdala (d=-0·18 vs -0·14), caudate (d=-0·13 vs -0·07), hippocampus (d=-0·12 vs -0·06), putamen (d=-0·18 vs -0·08), and intracranial volume (d=-0·14 vs 0·01). There was no difference between children and adults for the pallidum (p=0·79) or thalamus (p=0·89). Case-control differences in adults were non-significant (all p>0·03). Psychostimulant medication use (all p>0·15) or symptom scores (all p>0·02) did not influence results, nor did the presence of comorbid psychiatric disorders (all p>0·5).InterpretationWith the largest dataset to date, we add new knowledge about bilateral amygdala, accumbens, and hippocampus reductions in ADHD. We extend the brain maturation delay theory for ADHD to include subcortical structures and refute medication effects on brain volume suggested by earlier meta-analyses. Lifespan analyses suggest that, in the absence of well powered longitudinal studies, the ENIGMA cross-sectional sample across six decades of ages provides a means to generate hypotheses about lifespan trajectories in brain phenotypes.FundingNational Institutes of Health.

Published
2017

82. Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group

Author

Gao, Yidian, Staginnus, Marlene, Gao, Yidian, Staginnus, Marlene, Townend, Sophie, Arango, Celso, Bajaj, Sahil, Banaschewski, Tobias, Barker, Edward D., Benegal, Vivek, Berluti, Kathryn, Bernhard, Anka, Blair, Robert J.R., Boateng, Charlotte P.S., Bokde, Arun L.W., Brandeis, Daniel, Buitelaar, Jan K., Burt, S. Alexandra, Cardinale, Elise M., Castro-Fornieles, Josefina, Chen, Hui, Chen, Xianliang, Chester, Sally C., Colins, Olivier F., Cornwell, Harriet, Craig, Michael, Cubillo, Ana I., Desrivieres, Sylvane, Díaz, Dana E., Dietrich, Andrea, Dong, Daifeng, Dykstra, Anouk H., Franke, Barbara, Freitag, Christine M., Glennon, Jeffrey C., Gonzalez-Madruga, Karen, Hagan, Cindy C., Hoekstra, Pieter J., Holla, Bharath, Hyde, Luke W., Ibrahim, Karim, Jabeen, Nimrah, Jackson, Rebecca L., Jiang, Yali, Kohls, Gregor, Konrad, Kerstin, Kypta-Vivanco, Alexandra, Lamers, Kim, Ma, Ren, Marsh, Abigail A., Martinelli, Anne, Martinot, Jean-Luc, Michalska, Kalina J., Ming, Qingsen, Minosse, Silvia, Mitchell, Colter, Monk, Christopher S., Murphy, Declan, Mycue, Leah E., Naaijen, Jilly, Oosterling, Maaike, Passamonti, Luca, Pauli, Ruth, Penzol Alonso, Maria Jose, Phillips, Harriet, Ploe, Montana L., Raschle, Nora M., Roberts, Ruth, Rogers, Jack C., Rosa-Justicia, Mireia, Sagar-Ouriaghli, Ilyas, Schulze, Ulrike M.E., Schumann, Gunter, Sethi, Arjun, Smaragdi, Areti, Sonuga-Barke, Edmund J.S., Stadler, Christina, Stevens, Michael C., Sukhodolsky, Denis G., Sully, Kate, Sun, Xiaoqiang, Toschi, Nicola, Townsend, Christopher D., van der Wee, Nic J.A., Vermeiren, Robert, Viding, Essi, Wang, Xiaoping, Westerman, Heidi B., Wu, Qiong, Yao, Shuqiao, Zhang, Jibiao, Zhou, Jiansong, Zhou, Jiawei, Jahanshad, Neda, Thomopoulos, Sophia I., Ching, Christopher R.K., Kang, Melody J.Y., Thompson, Paul M., Klapwijk, Eduard T., Pine, Daniel S., Baskin-Sommers, Arielle, Cecil, Charlotte A.M., Aghajani, Moji, Walton, Esther, Fairchild, Graeme, and De Brito, Stephane A.

Abstract

Conduct disorder is associated with the highest burden of any mental disorder in childhood, yet its neurobiology remains unclear. Inconsistent findings limit our understanding of the role of brain structure alterations in conduct disorder. This study aims to identify the most robust and replicable brain structural correlates of conduct disorder.

Published
2024
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83. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Author

Abdulkadir, Mohamed, Tischfield, Jay A, King, Robert A, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, de Bruijn, Sebastian FTM, Elzerman, Lonneke, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hagstrøm, Julie, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Lamerz, Andreas, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Messchendorp, Marieke D, Mir, Pablo, Morer, Astrid, Münchau, Alexander, Murphy, Tara L, Openneer, Thaïra JC, Plessen, Kerstin J, Rath, Judith JG, Roessner, Veit, Fründt, Odette, Shin, Eun-Young, Sival, Deborah A, Song, Dong-Ho, Song, Jungeun, Stolte, Anne-Marie, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, State, Matthew W, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea

Subjects
Clinical and Health Psychology, Biomedical and Clinical Sciences, Psychology, Mental Health, Tourette Syndrome, Neurosciences, Neurodegenerative, Pediatric, Clinical Research, Attention Deficit Hyperactivity Disorder (ADHD), Infant Mortality, Serious Mental Illness, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Child, Child, Preschool, Europe, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Parent-Child Relations, Pregnancy, Pregnancy Complications, Psychiatric Status Rating Scales, Republic of Korea, Retrospective Studies, Severity of Illness Index, Sex Factors, Tic Disorders, United States, Young Adult, Attention-deficit hyperactivity disorder, Delivery, Obsessive-compulsive disorder, Prenatal, Tourette syndrome, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Published
2016

84. An Open Label Discontinuation Trial of Long-Term Used Off-Label Antipsychotic Drugs in People with Intellectual Disability: The Influence of Staff-Related Factors

Author

Kuijper, Gerda M. and Hoekstra, Pieter J.

Abstract

Background: Results of discontinuation of antipsychotics in people with intellectual disability are variable and may depend on staff factors. Method: We attempted to taper off antipsychotics in 14 weeks after which participants were free to restart. We investigated the influence of support professionals' feelings towards challenging behaviour, their knowledge of psychotropic drugs and clinicians' judgements of participants' behavioural functioning on whether or not antipsychotics were completely discontinued after 16, 28 and 40 weeks. Results: Of the 129 participants, 61% achieved discontinuation at 16 weeks; at 28 and 40 weeks, 46% and 40% were completely discontinued. Staff's feelings of Depression/Anger towards their client's behaviour, less knowledge about psychotropic medication and clinicians' judgements of behavioural worsening were negatively associated with achievement of discontinuation. Conclusions: To enhance discontinuation off-label drug use, staff's feelings should be explored, their knowledge of psychotropic drugs improved and reasons for clinicians' judgements of participants' behavioural worsening investigated.

Published
2019
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85. Exploring Barriers and Facilitators in the Implementation and Use of Guideline Recommendations on Antipsychotic Drug Prescriptions for People with Intellectual Disability

Author

Ramerman, Lotte, Hoekstra, Pieter J., and de Kuijper, Gerda

Abstract

Background: It is unknown why professionals' adherence to guideline recommendations on antipsychotic drug prescription in the intellectual disabilities care is insufficient. This study aimed to explore barriers and facilitators in the implementation and use of these recommendations. Methods: In-depth interviews with four intellectual disability physicians, two psychiatrists and five behavioural scientists were used to explore the implementation and use of guideline recommendations. Results: Barriers in adhering to recommendations were lack of collaboration of different disciplines involved in the treatment of psychiatric and behavioural disorders and lack of enforcement of an appropriate monitoring of side- and treatment effects. When guideline recommendations were translated into organizational policies, clinicians were able to divide responsibilities and tasks, needed to appropriately implement guideline recommendations in daily clinical practice. Conclusions: To facilitate the use of guideline recommendations, organizations should translate recommendations into organization-specific policies, involving physicians and behavioural scientists in this process, while simultaneously creating more practical and technological support.

Published
2018
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87. Sustainable action is needed more than ever: the European Society for Child and Adolescent Psychiatry welcomes the efforts of the European Commission and the decisions of the European Parliament on mental health care for children, adolescents and young people and calls on the Member States to act quickly

Author

Drobnič Radobuljac, Maja, Fegert, Jörg M., Vermeiren, Robert, Anagnostopoulos, Dimitris, Çuhadaroglu, Füsun Çetin, Crommen, Sofie, Eliez, Stephan, Kaltiala, Riittakerttu, Kravic, Nermina, Kotsis, Konstantinos, Danese, Andrea, Hillegers, Manon, Hoekstra, Pieter J., Kiss, Enikő, Klauser, Paul, Råberg Christensen, Anne Marie, and Schröder, Carmen

Subjects
MENTAL health laws, HEALTH services accessibility, HEALTH literacy, PSYCHIATRY, MENTAL health services, PSYCHIATRIC treatment, ANXIETY, COVID-19 pandemic, MENTAL depression, WELL-being, CHILDREN, ADULTS
Abstract

The article focuses on addressing the mental health crisis among children, adolescents, and young people in Europe, exacerbated by events like the COVID-19 pandemic. It discusses the impact on mental health, including increased anxiety, depression, and other issues, and highlights the European Union's response with comprehensive approaches and funding initiatives to improve mental health care accessibility, quality, and integration into broader policy frameworks.

Published
2024
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90. Suicidality Treatment Occurring in Paediatrics (STOP) Medication Suicidality Side Effects Scale in young people in two cohorts across Europe

Author

Santosh, Paramala, primary, Sala, Regina, additional, Lievesley, Kate, additional, Singh, Jatinder, additional, Arango, Celso, additional, Buitelaar, Jan K, additional, Castro-Fornieles, Josefina, additional, Coghill, David, additional, Dittmann, Ralf W, additional, Flamarique, Itziar, additional, Hoekstra, Pieter J, additional, Llorente, Cloe, additional, Purper-Ouakil, Diane, additional, Schulze, Ulrike, additional, Zuddas, Alessandro, additional, Parnell, Nathan, additional, Mohan, Mohapradeep, additional, and Fiori, Federico, additional

Published
2023
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91. Psychopharmacology in children and adolescents: unmet needs and opportunities

Author

Cortese, Samuele, primary, Purper-Ouakil, Diane, additional, Apter, Alan, additional, Arango, Celso, additional, Baeza, Inmaculada, additional, Banaschewski, Tobias, additional, Buitelaar, Jan, additional, Castro-Fornieles, Josefina, additional, Coghill, David, additional, Cohen, David, additional, Correll, Christoph U, additional, Grünblatt, Edna, additional, Hoekstra, Pieter J, additional, James, Anthony, additional, Jeppesen, Pia, additional, Nagy, Péter, additional, Pagsberg, Anne Katrine, additional, Parellada, Mara, additional, Persico, Antonio M, additional, Roessner, Veit, additional, Santosh, Paramala, additional, Simonoff, Emily, additional, Stevanovic, Dejan, additional, Stringaris, Argyris, additional, Vitiello, Benedetto, additional, Walitza, Susanne, additional, Weizman, Abraham, additional, Wong, Ian C K, additional, Zalsman, Gil, additional, Zuddas, Alessandro, additional, Carucci, Sara, additional, Butlen-Ducuing, Florence, additional, Tome, Maria, additional, Bea, Myriam, additional, Getin, Christine, additional, Hovén, Nina, additional, Konradsson-Geuken, Asa, additional, Lamirell, Daphne, additional, Olisa, Nigel, additional, Nafria Escalera, Begonya, additional, and Moreno, Carmen, additional

Published
2023
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96. Distinct associations between fronto-striatal glutamate concentrations and callous-unemotional traits and proactive aggression in disruptive behavior

Author

Craig, Michael C., Mulder, Leandra M., Zwiers, Marcel P., Sethi, Arjun, Hoekstra, Pieter J., Dietrich, Andrea, Baumeister, Sarah, Aggensteiner, Pascal M., Banaschewski, Tobias, Brandeis, Daniel, Werhahn, Julia E., Walitza, Susanne, Castro-Fornieles, Josefina, Arango, Celso, Schulze, Ulrike M.E., Glennon, Jeffrey C., Franke, Barbara, Santosh, Paramala J., Mastroianni, Mathilde, van Asten, Jack J.A., Buitelaar, Jan K., Lythgoe, David J., and Naaijen, Jilly

Published
2019
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