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56. Extensible and Configurable RISC-V Based Virtual Prototype

Author

Herdt, Vladimir, Große, Daniel, Le, Hoang M., Drechsler, Rolf, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Martin, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Kazmierski, Tom J., editor, Steinhorst, Sebastian, editor, and Große, Daniel, editor

Published
2020
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57. LLVM-based Hybrid Fuzzing with LibKluzzer (Competition Contribution)

Author

Le, Hoang M., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Wehrheim, Heike, editor, and Cabot, Jordi, editor

Published
2020
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58. Smooth Imitation Learning for Online Sequence Prediction

Author

Le, Hoang M., Kang, Andrew, Yue, Yisong, and Carr, Peter

Subjects
Computer Science - Learning
Abstract

We study the problem of smooth imitation learning for online sequence prediction, where the goal is to train a policy that can smoothly imitate demonstrated behavior in a dynamic and continuous environment in response to online, sequential context input. Since the mapping from context to behavior is often complex, we take a learning reduction approach to reduce smooth imitation learning to a regression problem using complex function classes that are regularized to ensure smoothness. We present a learning meta-algorithm that achieves fast and stable convergence to a good policy. Our approach enjoys several attractive properties, including being fully deterministic, employing an adaptive learning rate that can provably yield larger policy improvements compared to previous approaches, and the ability to ensure stable convergence. Our empirical results demonstrate significant performance gains over previous approaches., Comment: ICML 2016

Published
2016

59. Green tea polyphenols require the mitochondrial iron transporter, mitoferrin, for lifespan extension in Drosophila melanogaster

Author

Lopez, Terry E, Pham, Hoang M, Nguyen, Benjamin V, Tahmasian, Yerazik, Ramsden, Shannon, Coskun, Volkan, Schriner, Samuel E, and Jafari, Mahtab

Subjects
Biochemistry and Cell Biology, Biological Sciences, Aging, Complementary and Integrative Health, Nutrition, Generic health relevance, Animals, Antioxidants, Camellia sinensis, Drosophila Proteins, Drosophila melanogaster, Female, Fertility, Iron, Longevity, Male, Mitochondria, Polyphenols, Transferrin, fertility, green tea, iron, lifespan, mitoferrin, Zoology, Entomology
Abstract

Green tea has been found to increase the lifespan of various experimental animal models including the fruit fly, Drosophila melanogaster. High in polyphenolic content, green tea has been shown to reduce oxidative stress in part by its ability to bind free iron, a micronutrient that is both essential for and toxic to all living organisms. Due to green tea's iron-binding properties, we questioned whether green tea acts to increase the lifespan of the fruit fly by modulating iron regulators, specifically, mitoferrin, a mitochondrial iron transporter, and transferrin, found in the hemolymph of flies. Publicly available hypomorph mutants for these iron regulators were utilized to investigate the effect of green tea on lifespan and fertility. We identified that green tea could not increase the lifespan of mitoferrin mutants but did rescue the reduced male fertility phenotype. The effect of green tea on transferrin mutant lifespan and fertility were comparable to w1118 flies, as observed in our previous studies, in which green tea increased male fly lifespan and reduced male fertility. Expression levels in both w1118 flies and mutant flies, supplemented with green tea, showed an upregulation of mitoferrin but not transferrin. Total body and mitochondrial iron levels were significantly reduced by green tea supplementation in w1118 and mitoferrin mutants but not transferrin mutant flies. Our results demonstrate that green tea may act to increase the lifespan of Drosophila in part by the regulation of mitoferrin and reduction of mitochondrial iron.

Published
2016

68. Towards Early Validation of Firmware-Based Power Management Using Virtual Prototypes: A Constrained Random Approach

Author

Herdt, Vladimir, Le, Hoang M., Große, Daniel, Drechsler, Rolf, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Ruediger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Liang, Qilian, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zhang, Junjie James, Series Editor, Große, Daniel, editor, Vinco, Sara, editor, and Patel, Hiren, editor

Published
2019
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69. KLUZZER: Whitebox Fuzzing on Top of LLVM

Author

Le, Hoang M., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Chen, Yu-Fang, editor, Cheng, Chih-Hong, editor, and Esparza, Javier, editor

Published
2019
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70. Property-Driven Timestamps Encoding for Timeprints-Based Tracing and Monitoring

Author

Massoud, Rehab, Le, Hoang M., Drechsler, Rolf, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, André, Étienne, editor, and Stoelinga, Mariëlle, editor

Published
2019
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77. The impact of green tea polyphenols on development and reproduction in Drosophila melanogaster

Author

Lopez, Terry E, Pham, Hoang M, Barbour, Julia, Tran, Phillip, Van Nguyen, Benjamin, Hogan, Sean P, Homo, Richelle L, Coskun, Volkan, Schriner, Samuel E, and Jafari, Mahtab

Subjects
Agricultural, Veterinary and Food Sciences, Biomedical and Clinical Sciences, Food Sciences, Nutrition and Dietetics, Contraception/Reproduction, Behavioral and Social Science, Basic Behavioral and Social Science, Development, Drosophila, Green tea, Reproduction, Toxicity, development, green tea, reproduction, toxicity, Medical Physiology, Food sciences, Nutrition and dietetics
Abstract

Although, green tea has numerous health benefits, adverse effects with excessive consumption have been reported. Using Drosophila melanogaster, a decrease in male fertility with green tea was evidenced. Here, the extent of green tea toxicity on development and reproduction was investigated. Drosophila melanogaster embryos and larvae were exposed to various doses of green tea polyphenols (GTP). Larvae exposed to 10 mg/mL GTP were slower to develop, emerged smaller, and exhibited a dramatic decline in the number of emerged offspring. GTP protected flies against desiccation but sensitized them to starvation and heat stress. Female offspring exhibited a decline in reproductive output and decreased survival while males were unaffected. GTP had a negative impact on reproductive organs in both males and females (e.g., atrophic testes in males, absence of mature eggs in females). Collectively, the data show that high doses of GTP adversely affect development and reproduction of Drosophila melanogaster.

Published
2016

85. A Tool Using Ultrasonic Sensor for Measuring Breathing Rate

Author

Dang, Tin T., Nguyen Tran, Khai Q., Le, Hoang M., Tran, Khoa, Dinh, Anh, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Vo Van, Toi, editor, Nguyen Le, Thanh An, editor, and Nguyen Duc, Thang, editor

Published
2018
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87. On the Application of Formal Fault Localization to Automated RTL-to-TLM Fault Correspondence Analysis for Fast and Accurate VP-Based Error Effect Simulation: A Case Study

Author

Herdt, Vladimir, Le, Hoang M., Große, Daniel, Drechsler, Rolf, Angrisani, Leopoldo, Series editor, Arteaga, Marco, Series editor, Chakraborty, Samarjit, Series editor, Chen, Jiming, Series editor, Chen, Tan Kay, Series editor, Dillmann, Ruediger, Series editor, Duan, Haibin, Series editor, Ferrari, Gianluigi, Series editor, Ferre, Manuel, Series editor, Hirche, Sandra, Series editor, Jabbari, Faryar, Series editor, Kacprzyk, Janusz, Series editor, Khamis, Alaa, Series editor, Kroeger, Torsten, Series editor, Ming, Tan Cher, Series editor, Minker, Wolfgang, Series editor, Misra, Pradeep, Series editor, Möller, Sebastian, Series editor, Mukhopadhyay, Subhas Chandra, Series editor, Ning, Cun-Zheng, Series editor, Nishida, Toyoaki, Series editor, Panigrahi, Bijaya Ketan, Series editor, Pascucci, Federica, Series editor, Samad, Tariq, Series editor, Seng, Gan Woon, Series editor, Veiga, Germano, Series editor, Wu, Haitao, Series editor, Zhang, Junjie James, Series editor, Fummi, Franco, editor, and Wille, Robert, editor

Published
2018
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91. Static Mechanical Allodynia is a paradoxical painful touch-evoked tactile HYPO-aesthesia: A retrospective analysis of 86 patients with CRPS of the foot.

Author

de Andrade Melo Knaut, S., Hoang, M.-A., Bossard, E. K., Chiquito, V. R., Eduarda Mazepa, M., Portela, L. A., Zene, M. V., Packham, T. L., Dyer, J.-O., Mermet-Joret, N., Annoni, J.-M., and Spicher, C. J.

Subjects
*COMPLEX regional pain syndromes, *MCGILL Pain Questionnaire, *THRESHOLD (Perception), *NEURALGIA, *SYMPTOMS
Abstract

Objective: To determine the falsifiability of the proposed etiology of static mechanical allodynia (SMA) as a paradoxical painful touch-evoked slight tactile HYPO-aesthesia caused by Aβ axonal lesions in patients treated for Complex Regional Pain Syndrome (CRPS) of the foot. Methods: This is a retrospective analysis of prospectively collected clinical data of patients with CRPS of the foot. Patients who achieved resolution of their SMA following the assessment and treatment of the method of Somatosensory Pain Rehabilitation (SPR) were included in the study. The shift from SMA to an underlying tactile HYPO-aesthesia supported the recommendation of somatosensory re-learning of the method of SPR. Allodynography and Rainbow Pain Scale were two clinical examination signs used pre-treatment to quantify the allodynic territory. The quality and intensity of pain were assessed using the McGill Pain Questionnaire (MPQ). Then, the underlying tactile HYPO-aesthesia was assessed with the 2-Point Discrimination Test (2PDT) and Pressure Perception Threshold (PPT). Results: Eighty-six patients with a CRPS of the foot were included. On admission, 43 patients had a discrete, 26 a consequential and 17 a serious SMA. After disappearance of SMA, patients had a slight and partial underlying HYPO-aesthetic territory confirmed with a PTT mean of 2.8 g. Significant improvements were noted for the MPQ, PPT and 2PDT (p < 0.001) with a large effect size. Conclusion: This study confirms that SMA is a paradoxical painful touch-evoked tactile HYPO-aesthesia in patients with CRPS. Moreover, results support the effi- cacy of the method of SPR to improve neuropathic pain within this population. [ABSTRACT FROM AUTHOR]

Published
2024
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