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51. Effect of Chronic Kidney Disease or Anemia or Both on Cardiovascular Mortality in a 25-Year Follow-Up Study of Japanese General Population (From NIPPON DATA90)

Author

Kubo, Kota, primary, Okamura, Tomonori, additional, Sugiyama, Daisuke, additional, Hisamatsu, Takashi, additional, Hirata, Aya, additional, Kadota, Aya, additional, Kondo, Keiko, additional, Hirata, Takumi, additional, Higashiyama, Aya, additional, Hayakawa, Takehito, additional, Miyamoto, Yoshihiro, additional, Okayama, Akira, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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53. Relationship between Kidney Function and Subclinical Atherosclerosis Progression Evaluated by Coronary Artery Calcification

Author

Ganbaatar, Namuun, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Araki, Shin-Ichi, additional, Kume, Shinji, additional, Fujiyoshi, Akira, additional, Kadowaki, Sayaka, additional, Torii, Sayuki, additional, Kondo, Keiko, additional, Segawa, Hiroyoshi, additional, Salman, Ebtehal, additional, Miyazawa, Itsuko, additional, Yamamoto, Takashi, additional, Nakagawa, Yoshihisa, additional, Maegawa, Hiroshi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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55. Association between proprotein convertase subtilisin/kexin type 9 and subclinical cerebrovascular disease in the community.

Author

Kunimura, Ayako, Yano, Yuichiro, Hisamatsu, Takashi, Torii, Sayuki, Kondo, Keiko, Kadota, Aya, Fujiyoshi, Akira, Okamura, Tomonori, Watanabe, Yoshiyuki, Shiino, Akihiko, Nozaki, Kazuhiko, Ueshima, Hirotsugu, and Miura, Katsuyuki

Subjects
CEREBRAL small vessel diseases, CEREBROVASCULAR disease, SUBTILISINS, LDL cholesterol, COMMUNITIES, LACUNAR stroke, ARTERIAL stenosis
Abstract

Background and purpose: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new target for reducing low‐density lipoprotein cholesterol and incident cardiovascular disease, including stroke. However, the clinical relevance of circulating PCSK9 levels has been poorly elucidated in the general population, particularly in association with subclinical cerebrovascular disease including cerebral small vessel disease (CSVD) and intracranial artery stenosis (ICAS). Methods: In community‐dwelling Japanese men (n = 526) aged 46–82 years without a history of cardiovascular disease, the associations of serum PCSK9 levels with the prevalence of CSVD and ICAS were assessed using magnetic resonance imaging. CSVD included lacunar infarction, deep and subcortical white matter hyperintensity, periventricular hyperintensity and cerebral microbleeds. Results: The median (interquartile range) age at baseline and serum PCSK9 levels were 69 (63–74) years and 240 (205–291) ng/ml, respectively. After adjusting for traditional cardiovascular risk factors including low‐density lipoprotein cholesterol, multivariable Poisson regression with robust error variance revealed a significant association between PCSK9 levels (per 1 SD) and ICAS (relative risks 1.18, 95% confidence interval 1.02–1.37). Multivariable ordinal logistic regression for ICAS, with stenosis graded as mild (<50%) or moderate–severe (≥50%), revealed a similar association (common odds ratio 1.31, 95% confidence interval 1.04–1.64). However, no significant association was observed between serum PCSK9 levels and CSVD. Conclusions: Higher circulating PCSK9 levels were independently associated with an ICAS prevalence but not with CSVD prevalence. The quantification of circulating PCSK9 levels may help to identify individuals at high risk for cerebrovascular disease in the general population. [ABSTRACT FROM AUTHOR]

Published
2023
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56. Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome.

Author

Aizawa, Takanori, Wada, Yuko, Hasegawa, Kanae, Huang, Hai, Imamura, Tomohiko, Gao, Jingshan, Kashiwa, Asami, Kohjitani, Hirohiko, Fukuyama, Megumi, Kato, Koichi, Kato, Eri Toda, Hisamatsu, Takashi, Ohno, Seiko, Makiyama, Takeru, Kimura, Takeshi, and Horie, Minoru

Abstract

Aims More than one-third of type 2 long QT syndrome (LQT2) patients carry KCNH2 non-missense variants that can result in haploinsufficiency (HI), leading to mechanistic loss-of-function. However, their clinical phenotypes have not been fully investigated. The remaining two-thirds of patients harbour missense variants, and past studies uncovered that most of these variants cause trafficking deficiency, resulting in different functional changes: either HI or dominant-negative (DN) effects. In this study, we examined the impact of altered molecular mechanisms on clinical outcomes in LQT2 patients. Methods and results We included 429 LQT2 patients (234 probands) carrying a rare KCNH2 variant from our patient cohort undergoing genetic testing. Non-missense variants showed shorter corrected QT (QTc) and less arrhythmic events (AEs) than missense variants. We found that 40% of missense variants in this study were previously reported as HI or DN. Non-missense and HI-groups had similar phenotypes, while both exhibited shorter QTc and less AEs than the DN-group. Based on previous work, we predicted the functional change of the unreported variants—whether they cause HI or DN via altered functional domains—and stratified them as predicted HI (pHI)- or pDN-group. The pHI-group including non-missense variants exhibited milder phenotypes compared to the pDN-group. Multivariable Cox model showed that the functional change was an independent risk of AEs (P = 0.005). Conclusion Stratification based on molecular biological studies enables us to better predict clinical outcomes in the patients with LQT2. [ABSTRACT FROM AUTHOR]

Published
2023
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59. Comparison of HOMA-IR, HOMA-β% and disposition index between US white men and Japanese men in Japan: the ERA JUMP study

Author

Ahuja, Vasudha, Kadowaki, Takashi, Evans, Rhobert W., Kadota, Aya, Okamura, Tomonori, El Khoudary, Samar R., Fujiyoshi, Akira, Barinas-Mitchell, Emma J. M., Hisamatsu, Takashi, Vishnu, Abhishek, Miura, Katsuyuki, Maegawa, Hiroshi, El-Saed, Aiman, Kashiwagi, Atsunori, Kuller, Lewis H., Ueshima, Hirotsugu, Sekikawa, Akira, and for the ERA JUMP Study Group

Published
2015
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60. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Sumi, Masaki, Hisamatsu, Takashi, Fujiyoshi , Akira, Kadota, Aya, Miyagawa, Naoko, Kondo, Keiko, Kadowaki, Sayaka, Suzuki , Sentaro, Torii, Sayuki, Zaid Maryam, Sato, Atsushi, Arima, Hisatomi, Terada, Tomohiro, Miura, Katsuyuki, Ueshima , Hirotsugu, Horie Minoru, Nakano Yasutaka, Yamamoto Takashi, Hayashi Hideki, Ogawa Emiko, Maegawa Hiroshi, Miyazawa Itsuko, Murata Kiyoshi, Mitsunami Kenichi, Nozaki Kazuhiko, Tooyama Ikuo, Shiino Akihiko, Tsuru Teruhiko, Ogita Hisakazu, Shimizu Akio, Miyamatsu Naomi, Kita Toru, Kimura Takeshi, Nishio Yoshihiko, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Edmundowicz Daniel, Ohkubo Takayoshi, Hozawa Atsushi, Murakami Yoshitaka, Okuda Nagako, Arima Hisatomi, Kita Yoshikuni, Hisamatsu Takashi, Higashiyama Aya, Nagasawa Shinya, Azuma Koichiro, Yanagita Masahiko, Abbott Robert D., Kadota Aya, Ohno Seiko, Fujiyoshi Akira, Takashima Naoyuki, Kadowaki Takashi, Kadowaki Sayaka, Miyagawa Naoko, Kondo Keiko, Torii Sayuki, Saito Yoshino, Suzuki Sentaro, Ito Takahiro, Satoh Atsushi, and Yamazoe Masahiro

Subjects
Adult, Male, medicine.medical_specialty, Alcohol Drinking, Epidemiology, alcohol consumption, Population, Adipose tissue, 030209 endocrinology & metabolism, Intra-Abdominal Fat, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, medicine, Humans, 030212 general & internal medicine, visceral adipose tissue, Adverse effect, education, Nutrition, Aged, lcsh:R5-920, education.field_of_study, Anthropometry, business.industry, anthropometric obesity indice, Confounding, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, fat deposition, Obesity, Subcutaneous Fat, Abdominal, Epidemiologic Studies, Cross-Sectional Studies, Population Surveillance, Original Article, lcsh:Medicine (General), Tomography, X-Ray Computed, business, Body mass index
Abstract

Background: Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods: From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results: We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend

Published
2019

61. Relationship of Four Blood Pressure Indexes to Subclinical Cerebrovascular Diseases Assessed by Brain MRI in General Japanese Men

Author

Salman, Ebtehal, primary, Kadota, Aya, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Torii, Sayuki, additional, Fujiyoshi, Akira, additional, Kondo, Keiko, additional, Watanabe, Yoshiyuki, additional, Arima, Hisatomi, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2022
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62. A Comparison of Segment-Specific and Composite Measures of Carotid Intima-Media Thickness and their Relationships with Coronary Calcium

Author

Zaid, Maryam, primary, Fujiyoshi, Akira, additional, Hisamatsu, Takashi, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Satoh, Atsushi, additional, Sekikawa, Akira, additional, Barinas-Mitchell, Emma, additional, Horie, Minoru, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2022
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64. Cross-Sectional Comparison of Coronary Artery Calcium Scores Between Caucasian Men in the United States and Japanese Men in Japan: The Multi-Ethnic Study of Atherosclerosis and the Shiga Epidemiological Study of Subclinical Atherosclerosis

Author

Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Kadowaki, Takashi, Kadowaki, Sayaka, Zaid, Maryam, Hisamatsu, Takashi, Sekikawa, Akira, Budoff, Matthew J., Liu, Kiang, Ueshima, Hirotsugu, Fujiyoshi, Akira, Miura, Katsuyuki, Ohkubo, Takayoshi, Kadowaki, Takashi, Kadowaki, Sayaka, Zaid, Maryam, Hisamatsu, Takashi, Ueshima, Hirotsugu, Miura, Katsuyuki, Hisamatsu, Takashi, Ueshima, Hirotsugu, Ohkubo, Takayoshi, Sekikawa, Akira, Budoff, Matthew J., and Liu, Kiang

Published
2014
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65. Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men.

Author

Kondo, Keiko, Arima, Hisatomi, Fujiyoshi, Akira, Sekikawa, Akira, Kadota, Aya, Hisamatsu, Takashi, Torii, Sayuki, Shiino, Akihiko, Morino, Katsutaro, Miyagawa, Naoko, Segawa, Hiroyoshi, Watanabe, Yoshiyuki, Maegawa, Hiroshi, Nozaki, Kazuhiko, Miura, Katsuyuki, and Ueshima, Hirotsugu

Subjects
OMEGA-3 fatty acids, UNSATURATED fatty acids, LACUNAR stroke, JAPANESE people, MAGNETIC resonance imaging, EICOSAPENTAENOIC acid
Abstract

Background: An association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men. Methods: Participants were community-dwelling men (40–79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs. Results: Of a total of 739 men, the numbers (crude prevalence in %) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67–0.97). There were no significant associations of n-3 PUFAs with the other types of lesions. Conclusions: n-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain. [ABSTRACT FROM AUTHOR]

Published
2022
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68. Prologue: Special Spotlight Issue on Japan

Author

Yano, Yuichiro, primary, Nishiyama, Akira, additional, Ishimitsu, Toshihiko, additional, Kashihara, Naoki, additional, Rakugi, Hiromi, additional, Tamura, Kouichi, additional, Itoh, Hiroshi, additional, Tsuchihashi, Takuya, additional, Sakima, Atsushi, additional, Arima, Hisatomi, additional, Matayoshi, Tetsutaro, additional, Imai, Yutaka, additional, Miura, Katsuyuki, additional, Hisamatsu, Takashi, additional, Asayama, Kei, additional, Ohkubo, Takayoshi, additional, Node, Kouihci, additional, and Kario, Kazuomi, additional

Published
2021
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69. Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men

Author

Kimani Cecilia, Kadota Aya, Miura Katsuyuki, Fujiyoshi Akira, Zaid Maryam, Kadowaki Sayaka, Hisamatsu Takashi, Arima Hisatomi, Horie Minoru, Ueshima Hirotsugu, Yamamoto Takashi, Maegawa Hiroshi, Murata Kiyoshi, Nozaki Kazuhiko, Shiino Akihiko, Toyama Ikuo, Tsuru Teruhiko, Ogita Hisakazu, Takashima Naoyuki, Kadowaki Takashi, Miyamatsu Naomi, Miyagawa Naoko, Torii Sayuki, Hayashi Hideki, Nakano Yasutaka, Ogawa Emiko, Miyazawa Itsuko, Shimizu Akio, Abbott Robert D., Kondo Keiko, Suzuki Sentaro, Ito Takahiro, Andoh Akira, Kunimura Ayako, Nishio Yoshihiko, Mitsunami Kenichi, Kita Toru, Kimura Takeshi, Tabara Yasuharu, Nakamura Yasuyuki, Okamura Tomonori, Sekikawa Akira, Barinas-Mitchell Emma J. M., Ohkubo Takayoshi, Kita Yoshikuni, Murakami Yoshitaka, Hozawa Atsushi, Okuda Nagako, Higashiyama Aya, Ohno Seiko, Nagasawa Shinya, Yamazo Masahiro, Saito Yoshino, Edmundowicz Daniel, Satoh Atsushi, Azuma Koichiro, Yanagita Masahiko, Sawamura Tatsuya, and Igase Michiya

Subjects
Adult, Male, medicine.medical_specialty, Aortic Diseases, Renal function, Blood lipids, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery, Logistic regression, Calcification, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Internal Medicine, Humans, Medicine, cardiovascular diseases, Vascular Calcification, Generalized estimating equation, Aorta, Aged, 2. Zero hunger, business.industry, Incidence, Biochemistry (medical), nutritional and metabolic diseases, Odds ratio, Middle Aged, Prognosis, medicine.disease, Coronary Vessels, Aortic artery, Cardiovascular diseases, Risk factors, 3. Good health, Blood pressure, Cardiology, Original Article, Cardiology and Cardiovascular Medicine, business, Body mass index, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

Aims: Calcification in the coronary and aortic arteries has been linked to cardiovascular morbidity and mortality. The pathophysiological influence of aortic artery calcification (AAC) differs from that of coronary artery calcification (CAC). We aimed to compare the relationships between CAC and AAC and cardiovascular disease (CVD) risk factors. Methods: We examined a random sample of 1035 Japanese men aged 40–79 years. CAC and AAC were measured by computed tomography and scored according to the Agatston method. Using a logistic regression, we calculated the odds ratio (OR) as being in the highest quintile (Q5) of the calcification score compared to the lower quintiles (Q1–Q4) per 1 standard deviation higher CVD risk factor. Models were simultaneously adjusted for age, body mass index (BMI), systolic blood pressure, smoking (pack-year), alcohol intake, hemoglobin A1c, uric acid, estimated glomerular filtration rate (eGFR), serum lipids, and C-reactive protein. Differences in ORs were investigated using a generalized estimating equation. We performed a multiple linear regression using log-transformed CAC and AAC values as dependent variables. Results: CAC and AAC were independently associated with age (OR, 95% CI: 2.30 [1.77–2.98] for CAC and 3.48 [2.57–4.73] for AAC), p for difference < 0.001), systolic blood pressure (1.29 [1.08–1.53] and 1.28 [1.07–1.54], p for difference = 0.270), and smoking (1.22, [1.04–1.43] and 1.34 [1.13–1.58]) p for difference = 0.071). Alcohol correlated with AAC only (1.17 [0.97–1.41] for CAC and 1.42 [1.16–1.73] for AAC, p for difference = 0.020). Conclusions: CAC and AAC were associated with similar CVD risk factors. The strength of association slightly differed between CAC and AAC.

Published
2019

71. Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis

Author

Hisamatsu, Takashi, primary, Ohkubo, Takayoshi, additional, Hozawa, Atsushi, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Kadota, Aya, additional, Takashima, Naoyuki, additional, Shitara, Satoshi, additional, Arima, Hisatomi, additional, Nakagawa, Yoshihisa, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2021
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72. Abstract P096: Association Of Accurately Measured Office, Self-measured Home, And Ambulatory Blood Pressure And Their Variability With Intracranial Arterial Stenosis

Author

Hisamatsu, Takashi, primary, Ohkubo, Takayoshi, additional, Fujiyoshi, Akira, additional, Torii, Sayuki, additional, Segawa, Hiroyoshi, additional, Kondo, Keiko, additional, Kadota, Aya, additional, Takashima, Naoyuki, additional, Shitara, Satoshi, additional, Arima, Hisatomi, additional, Nakagawa, Yoshihisa, additional, Watanabe, Yoshiyuki, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Ueshima, Hirotsugu, additional, and Miura, Katsuyuki, additional

Published
2021
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78. Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study

Author

Moniruzzaman, Mohammad, primary, Kadota, Aya, additional, Shiino, Akihiko, additional, Fujiyoshi, Akira, additional, Ito, Takahiro, additional, Haidar Syaifullah, Ali, additional, Miyagawa, Naoko, additional, Kondo, Keiko, additional, Hisamatsu, Takashi, additional, Segawa, Hiroyoshi, additional, Tooyama, Ikuo, additional, Ueshima, Hirotsugu, additional, Miura, Katsuyuki, additional, and _, _, additional

Published
2021
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79. Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men

Author

Syaifullah, Ali Haidar, primary, Shiino, Akihiko, additional, Fujiyoshi, Akira, additional, Kadota, Aya, additional, Kondo, Keiko, additional, Ito, Takahiro, additional, Segawa, Hiroyoshi, additional, Moniruzzaman, Mohammad, additional, Waki, Takashi, additional, Miyagawa, Naoko, additional, Tooyama, Ikuo, additional, Ueshima, Hirotsugu, additional, Miura, Katsuyuki, additional, Horie, Minoru, additional, Nakagawa, Yoshihisa, additional, Yamamoto, Takashi, additional, Nakano, Yasutaka, additional, Ogawa, Emiko, additional, Maegawa, Hiroshi, additional, Morino, Katsutaro, additional, Miyazawa, Itsuko, additional, Watanabe, Yoshiyuki, additional, Nozaki, Kazuhiko, additional, Andoh, Akira, additional, Tsuru, Teruhiko, additional, Ogita, Hisakazu, additional, Miyamatsu, Naomi, additional, Nakamura, Yasuyuki, additional, Torii, Sayuki, additional, Kadowaki, Takashi, additional, Kadowaki, Sayaka, additional, Suzuki, Sentaro, additional, Kunimura, Ayako, additional, Higashiyama, Aya, additional, Okamura, Tomonori, additional, Azuma, Koichiro, additional, Sawamura, Tatsuya, additional, Igase, Michiya, additional, Tabara, Yasuharu, additional, Sekikawa, Akira, additional, Barinas-Mitchell, Emma J.M., additional, Edmundowicz, Daniel, additional, Ohkubo, Takayoshi, additional, Hozawa, Atsushi, additional, Murakami, Yoshitaka, additional, Okuda, Nagako, additional, Arima, Hisatomi, additional, Satoh, Atsushi, additional, Kita, Yoshikuni, additional, Hisamatsu, Takashi, additional, Yanagita, Masahiko, additional, Abbott, Robert D., additional, Ohno, Seiko, additional, Takashima, Naoyuki, additional, Zaid, Maryam, additional, and Saito, Yoshino, additional

Published
2021
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81. Differences between home blood pressure and strictly measured office blood pressure and their determinants in Japanese men

Author

KADOWAKI, Sayaka, KADOWAKI, Takashi, HOZAWA, Atsushi, FUJIYOSHI, Akira, HISAMATSU, Takashi, SATOH, Atsushi, ARIMA, Hisatomi, Tanaka-Mizuno, Sachiko, TORII, Sayuki, KONDO, Keiko, KADOTA, Aya, Masaki, Kamal, OKAMURA, Tomonori, OHKUBO, Takayoshi, MIURA, Katsuyuki, UESHIMA, Hirotsugu, and Shiga, Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group

Subjects
Male, medicine.medical_specialty, Population level, Physiology, Office blood pressure, Population, Blood Pressure, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Linear regression, Internal Medicine, Medicine, Humans, 030212 general & internal medicine, education, Rest time, Antihypertensive Agents, education.field_of_study, business.industry, Home blood pressure, Blood Pressure Determination, General population, Blood Pressure Monitoring, Ambulatory, Individual level, Blood pressure, Hypertension, Cardiology and Cardiovascular Medicine, business
Abstract

Conventional office blood pressure (OBP) and home blood pressure (HBP) measurements are often inconsistent. The purpose of this research was (1) to test whether strictly measured OBP values with sufficient rest time before measurement (st-OBP) is comparable to HBP at the population level and (2) to ascertain whether there are particular determinants for the difference between HBP and st-OBP at the individual level. Data from a population-based group of 1056 men aged 40–79 years were analyzed. After a five-min rest, st-OBP was measured twice. HBP was measured after a 2-min rest every morning for seven consecutive days. To determine factors related to ΔSBP (HBP minus st-OBP measurements), multiple linear regression analyses and analyses of covariance were performed. While st-OBP and HBP were comparable (136.5 vs. 137.2 mmHg) at the population level, ΔSBP varied with a standard deviation of 13.5 mmHg. Smoking was associated with a larger ΔSBP regardless of antihypertensive usage, and BMI was associated with a larger ΔSBP in participants using antihypertensive drugs. The adjusted mean ΔSBP in the highest BMI tertile category was 4.6 mmHg in participants taking antihypertensive drugs. st-OBP and HBP measurements were comparable at the population level, although the distribution of ΔSBP was considerably broad. Smokers and obese men taking antihypertensive drugs had higher HBP than st-OBP, indicating that their blood pressure levels are at risk of being underestimated. Therefore, this group would benefit from the addition of HBP measurements.

Published
2020

82. Association between Psychological Factors and Evacuation Status and the Incidence of Cardiovascular Diseases after the Great East Japan Earthquake: A Prospective Study of the Fukushima Health Management Survey

Author

Sanoh, Toshiki, primary, Eguchi, Eri, additional, Ohira, Tetsuya, additional, Hayashi, Fumikazu, additional, Maeda, Masaharu, additional, Yasumura, Seiji, additional, Suzuki, Yuriko, additional, Yabe, Hirooki, additional, Takahashi, Atsushi, additional, Takase, Kanae, additional, Harigane, Mayumi, additional, Hisamatsu, Takashi, additional, Ogino, Keiki, additional, Kanda, Hideyuki, additional, and Kamiya, Kenji, additional

Published
2020
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83. Interaction between dietary marine-derived n-3 fatty acids intake and J-point elevation on the risk of cardiac death: a 24-year follow-up of Japanese men

Author

Hisamatsu, Takashi, Miura, Katsuyuki, Ohkubo, Takayoshi, Yamamoto, Takashi, Fujiyoshi, Akira, Miyagawa, Naoko, Kadota, Aya, Takashima, Naoyuki, Okuda, Nagako, Matsumura, Yasuhiro, Yoshita, Katsushi, Kita, Yoshikuni, Murakami, Yoshitaka, Nakamura, Yasuyuki, Okamura, Tomonori, Horie, Minoru, Okayama, Akira, and Ueshima, Hirotsugu

Published
2013
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87. Cardiac Conduction Disorders as Markers of Cardiac Events in Myotonic Dystrophy Type 1

Author

Itoh, Hideki, primary, Hisamatsu, Takashi, additional, Tamura, Takuhisa, additional, Segawa, Kazuhiko, additional, Takahashi, Toshiaki, additional, Takada, Hiroto, additional, Kuru, Satoshi, additional, Wada, Chizu, additional, Suzuki, Mikiya, additional, Suwazono, Shugo, additional, Sasaki, Shingo, additional, Okumura, Ken, additional, Horie, Minoru, additional, Takahashi, Masanori P., additional, and Matumura, Tsuyoshi, additional

Published
2020
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89. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated With Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study

Author

Fujiyoshi, Akira, primary, Miura, Katsuyuki, additional, Ohkubo, Takayoshi, additional, Miyagawa, Naoko, additional, Saito, Yoshino, additional, Miyazawa, Itsuko, additional, Shiino, Akihiko, additional, Kadota, Aya, additional, Kadowaki, Sayaka, additional, Hisamatsu, Takashi, additional, Torii, Sayuki, additional, Takashima, Naoyuki, additional, Tooyama, Ikuo, additional, and Ueshima, Hirotsugu, additional

Published
2020
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90. Elevated Fasting Blood Glucose Levels Are Associated With Lower Cognitive Function, With a Threshold in Non-Diabetic Individuals: A Population-Based Study

Author

Liu, Ziyi, primary, Zaid, Maryam, additional, Hisamatsu, Takashi, additional, Tanaka, Sachiko, additional, Fujiyoshi, Akira, additional, Miyagawa, Naoko, additional, Ito, Takahiro, additional, Kadota, Aya, additional, Tooyama, Ikuo, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2020
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93. Lipoprotein particles and coronary artery calcium in middle-aged US-White and Japanese men

Author

Mahajan, Hemant, primary, Zaid, Maryam, additional, Mackey, Rachel, additional, Kadota, Aya, additional, Vishnu, Abhishek, additional, Fujiyoshi, Akira, additional, Vasudha, Ahuja, additional, Hisamatsu, Takashi, additional, Evans, Rhobert, additional, Okamura, Tomonori, additional, Miura, Katsuyuki, additional, Kuller, Lewis, additional, Ueshima, Hirotsugu, additional, and Sekikawa, Akira, additional

Published
2019
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94. Coronary Artery Calcification for Prevention of Atherosclerotic Cardiovascular Disease

Author

Hisamatsu, Takashi

Subjects
primary prevention, nutritional and metabolic diseases, atherosclerotic cardiovascular disease, epidemiology, cardiovascular diseases, coronary artery calcification
Abstract

Atherosclerotic cardiovascular disease （ASCVD）,including coronary heart disease, remains a major cause of death and disability among developed countries. Coronary artery calcification （CAC）, which is detected by computed tomography scanning, is a well-known measure of subclinical atherosclerosis. CAC is considered to have important implications for understanding the long-term accumulated burden of cardiovascular risk factors and for the possibility of reclassification at the preclinical phase for preventing ASCVD. This review focuses on CAC and its usability in primary prevention of ASCVD. Numerous epidemiological studies, mainly in Western countries, have indicated that, among asymptomatic individuals, the CAC score is associated with future ASCVD. Additionally, the CAC score provides improved predictive values for estimating the risk of ASCVD beyond traditional cardiovascular risk factors. However, a lack of evidence for this score in other populations warrants further investigations. Clinical trials are also necessary to demonstrate the usefulness and safety of CAC screening for primary prevention of ASCVD.

Published
2017

95. Association of self-measured home, ambulatory, and strictly measured office blood pressure and their variability with intracranial arterial stenosis.

Author

Takashi Hisamatsu, Takayoshi Ohkubo, Atsushi Hozawa, Akira Fujiyoshi, Sayuki Torii, Hiroyoshi Segawa, Keiko Kondo, Aya Kadota, Naoyuki Takashima, Satoshi Shitara, Hisatomi Arima, Yoshihisa Nakagawa, Yoshiyuki Watanabe, Akihiko Shiino, Kazuhiko Nozaki, Hirotsugu Ueshima, Katsuyuki Miura, Hisamatsu, Takashi, Ohkubo, Takayoshi, and Hozawa, Atsushi

Published
2021
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98. Abstract P009: Association Between Intracranial Subclinical Vessel Diseases and Cognition in a Community-Based Sample of Japanese Men: Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

Author

Ito, Takahiro, primary, Fujiyoshi, Akira, additional, Ohkubo, Takayoshi, additional, Shiino, Akihiko, additional, Nozaki, Kazuhiko, additional, Miyagawa, Naoko, additional, Torii, Sayuki, additional, Hisamatsu, Takashi, additional, Miura, Katsuyuki, additional, and Ueshima, Hirotsugu, additional

Published
2019
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