51. Impact de l’augmentation de la clairance rénale de la créatinine sur la guérison des infections bactériennes en réanimation
- Author
-
Bardon, Jean, Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), and Hervé Mentec
- Subjects
Antimicrobials ,Antibiotique ,MESH: Anti-Bacterial Agents ,Clairance rénale augmentée ,Augmented Renal clearance ,MESH: Resuscitation ,Réanimation ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Augmented renal clearance (ARC) is associated with lower plasma concentrations of antibiotics. The aim ofCLEAAR study was to assess the clinical course of patients with antimicrobial treatment for infection and ARC,defined as measured creatinine clearance = 130ml / min / 1.73m2.In this prospective bicentric study, patients hospitalized in intensive care unit (ICU) with sepsis requiring anantimicrobial therapy, not dialyzed, were included.Primary endpoint was failure of antimicrobial therapy defined as death related to sepsis, continuation ofantimicrobial treatment >48 hours beyond the expected duration, modification of antimicrobial therapy otherthan de-escalation or reintroduction of antimicrobials within 72 hours after end of treatment.Sixty three patients were included, 21% had ARC. Patients with ARC were significantly younger (53years (48-61.5) vs 67years (62.5-78), respectively, p48h au-delà de la durée prévue, la modification de l’antibiothérapie horsdésescalade thérapeutique ou la reprise d’une antibiothérapie dans les 72h suivant la fin du traitement.Parmi les 63 patients inclus, 21% présentaient une CRA. Les patients ayant une CRA étaient significativementplus jeunes (53ans (48-61,5) contre 67ans (62,5-78) respectivement, p
- Published
- 2017