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443 results on '"Herpin D"'

56. Assessment of antihypertensive effect by blood pressure monitoring: applications to bisoprolol and lisinopril in a double-blind study

Author

Poggi L, Prost Pl, Lyon A, Battistella P, Honore P, Bernard Vaisse, Conte D, Faiez Zannad, Contard S, Denis J, J. M. Mallion, S Boutelant, Herpin D, and Roland Asmar

Subjects
Male, medicine.medical_specialty, Ambulatory blood pressure, Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, Placebo, Essential hypertension, Double-Blind Method, Lisinopril, Internal medicine, Medicine, Bisoprolol, Humans, Antihypertensive Agents, Pharmacology, business.industry, Blood Pressure Monitoring, Ambulatory, Middle Aged, medicine.disease, Endocrinology, Blood pressure, ACE inhibitor, Ambulatory, Hypertension, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, circulatory and respiratory physiology, medicine.drug
Abstract

The aim of this study was to evaluate the antihypertensive effect of drugs according to the initial ambulatory blood pressure (BP) level. After a 15-day placebo run-in period, 105 patients with moderate essential hypertension (mean age, 52 years) underwent 24-h BP monitoring (spacelabs: 1 measure/15 min). Patients were subdivided into two groups: the "High" group, with 24-h mean values of systolic BP (SBP) > 137 or diastolic BP (DBP) > 87 mm Hg, and the "Low" group, with SBP < or = 137 and DBP < or = 87 mm Hg. All patients received, in a random and double-blind design, either bisoprolol (10 mg q.d.) or lisinopril (20 mg q.d.) for 8 weeks. At the end of this active treatment period, office and ambulatory BP measurements were performed. Casual measurements revealed similar BP decreases in all subgroups receiving bisoprolol and lisinopril; BP monitoring showed that the antihypertensive effect depended on the baseline mean 24-h value; -15/-12 mm Hg for bisoprolol and -18/-13 mm Hg for lisinopril in the High group; -7/-6 mm Hg for bisoprolol and -6/-6 mm Hg for lisinopril in the Low group. This study shows that the antihypertensive effect depended on initial ambulatory BP values, with a lower BP decrease in the Low group. Assessment of the antihypertensive effect on ambulatory BP is useful in clinical trials.

Published
1997

61. Non-invasive ambulatory blood pressure variability and cardiac baroreflec sensitivity

Author

Siche, J.P., Herpin, D., Asmar, R.G., Poncelet, P., Chamontin, B., Comparat, V., Gressin, V., Boutelant, S., Mallion, J.M., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph]
Published
1995

75. [Comparative effects of angiotensin converting enzyme inhibitors and calcium inhibitors related to baseline ambulatory blood pressure. A French multicenter study]

Author

Herpin D, Vaïsse B, Raud-Raynier P, Boijoux C, Pitiot M, Asmar R, Contard S, philippe gosse, de Gaudemaris R, and Zannad F

Subjects
Adult, Male, Hypertension, Ambulatory Care, Humans, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, Female, France, Middle Aged, Calcium Channel Blockers, Retrospective Studies
Abstract

This multicenter study was aimed at determining whether the baseline ambulatory blood pressure (BP) level does influence the efficacy of angiotensin-converting enzyme inhibitors (CEI) and that of calcium antagonists (CA) to the same degree.The BP recordings of 236 patients with mild to moderate hypertension were reviewed: these subjects previously entered clinical trials comprising a mean 2-week placebo period and a mean 6-week active treatment phase (CEI = 115, CA = 121). The 24-hour baseline ambulatory BP was considered as high when greater than 139/87 mmHg, according to Staessen's meta-analysis.In the patients with an high baseline ambulatory BP, CEI and CA have had roughly a similar effect (reduction in systolic = 9.5 +/- 7.8% vs 7.7 +/- 6.3%, NS; reduction in diastolic = 9.8 +/- 8.6% vs 8.3 +/- 5.8%, NS). Conversely, the patients with a baseline ambulatory BP level lower than or equal to 139/87 mmHg experienced a greater reduction in ambulatory BP with CEI than with CA (systolic = 7.9 +/- 7.0% vs 0.6 +/- 6.7%, p = 0.0001; diastolic: 5.0 +/- 7.4% vs 1.9 +/- 7.6%, p = 0.040). Finally, further analysis found the threshold of drug efficacy to be 120/80 and 135/85 mmHg in CEI and CA patients respectively.1) CEI are more effective than CA in patients with a low ambulatory BP only. 2) The risk of a visceral hypoperfusion seems however to be limited, since CEI do not reduce diastolic ambulatory BP further, when its baseline level is lower than 80 mmHg.

Published
1992

98. HOT study

Author

Herpin, D, primary, Mallion, J-M, additional, Dahan, R, additional, Benkritly, A, additional, Boutelant, S, additional, Baguet, J-P, additional, and Noirclerc, M, additional

Published
1997
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