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51. Kinetics of α-amylase secretion in <TOGGLE>Aspergillus oryzae</TOGGLE>

Author

Henriksen, Anne L. Santerre, Carlsen, Morten, Bang, Henriette de, and Nielsen, Jens

Abstract

Pulse and pulse-chase experiments have been performed to study L-[35S] methionine incorporation and protein secretion kinetics in Aspergillus oryzae. Pulse experiments confirmed the mechanism of methionine uptake reported previously for Penicillium chrysogenum (Benko et al., 1967). Pulse-chase experiments were carried out to investigate the α-amylase secretion kinetics in A. oryzae. No unglycosylated α-amylase was detected neither intracellularly nor extracellularly demonstrating that glycosylation was not the rate controlling step in the secretory pathway. The pulse chase experiments indicated that there are two pools of intracellular α-amylase: a fast secreted and a slow secreted. The secretion of those two pools were described with a kinetic model, which was fitted to the pulse chase experiments. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 65: 76–82, 1999.

Published
1999
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52. Serum Dioxin and Diabetes Mellitus in Veterans of Operation Ranch Hand

Author

Henriksen, Gary L., Ketchum, Norma S., Michalek, Joel E., and Swaby, James A.

Abstract

We studied diabetes mellitus and glucose and insulin levels in Air Force veterans exposed to Agent Orange and its contaminant, 2,3,7,8tetrachlorodibenzopdioxin dioxin, during the Vietnam War. The index subjects of the Air Force's ongoing 20year prospective epidemiologic study are veterans of Operation Ranch Hand N 989, the unit responsible for aerial herbicide spraying in Vietnam from 1962 to 1971. Other Air Force veterans who served in Southeast Asia during the same period but were not involved with spraying herbicides serve as Comparisons N 1,276. The median serum dioxin level in the Ranch Hand group was 12.2 parts per trillion ppt range 0–617.8 ppt, and the median dioxin level in the Comparison group was 4.0 ppt range 0–10 ppt. We found that glucose abnormalities relative risk 1.4 95 confidence limits CL 1.1, 1.8, diabetes prevalence relative risk 1.5 95 CL 1.2, 2.0, and the use of oral medications to control diabetes relative risk 2.3 95 CL 1.3, 3.9 increased, whereas timetodiabetesonset decreased with dioxin exposure. Serum insulin abnormalities relative risk 3.4 95 CL 1.9, 6.1 increased with dioxin exposure in nondiabetics. These results indicate an adverse relation between dioxin exposure and diabetes mellitus, glucose metabolism, and insulin production.

Published
1997

53. Serum Dioxin, Testosterone, and Gonadotropins in Veterans of Operation Ranch Hand

Author

Henriksen, Gary L., Michalek, Joel E., Swaby, James A., and Rahe, Alton J.

Abstract

We studied whether exposure to Agent Orange and its contaminant, 2,3,7,8tetrachlorodibenzopdioxin dioxin, during the Vietnam War is related to current testosterone, folliclestimulating hormone, luteinizing hormone, or testicular abnormalities, sperm count, sperm abnormalities, or testicular volume. The index subjects were veterans of Operation Ranch Hand, the unit responsible for aerial herbicide spraying in Vietnam from 1962 to 1971. The referent cohort comprises Air Force veterans who served in Southeast Asia during the same period but were not involved with spraying herbicides. Referents were matched to Ranch Hands on date of birth, race, and military occupation. We found no consistent or meaningful association between serum dioxin levels and any of these outcome variables. Epidemiology 19967352357

Published
1996

54. Vaccination with Protein‐Conjugated and Native Type 3 Capsular Polysaccharide in an Ethanol‐Fed Rat Model of Pneumococcal Pneumonia

Author

Henriksen, Jeffrey L., Preheim, Laurel C., and Gentry, Martha J.

Abstract

A chronic ethanol‐fed rat model was used to determine the effect of alcohol ingestion on production of antibody to type 3 pneumococcal capsular polysaccharide. Sprague‐Dawley rats were fed a liquid diet containing 36% of calories as ethanol (ethanol‐fed), an isocaloric diet containing dextrin‐maltose (pair‐fed) or standard rat chow (chow‐fed). After 7 days of feeding, the rats were vaccinated subcutaneously with placebo or with either 25 μg of type 3 pneumococcal capsular polysaccharide (SpnCP) or 5 μg of SpnCP linked to the protein carrier CRM197(SpnCP/CRM197). Rats given the conjugated vaccine received a booster injection 14 days later. Maximum antibody titers were observed six days postvaccination for rats given SpnCP alone and 21 days postvaccination for rats given SpnCP/CRM197. All rats were infected transtracheally with 2–3 times the expected lethal dose50for each feeding group of type 3 Streptococcus pneumoniaeon the day of peak antibody titers. Mortality was recorded for a 10‐day period. Vaccination with SpnCP increased survival of ethanol‐ and chow‐fed, but not pair‐fed rats. This protection was only statistically significant in the chow‐fed group (p< 0.01). Vaccination with SpnCP/CRM197moderately increased survival of rats in all three feeding groups, but this was not statistically significant in any of them.

Published
1997
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59. Conceptual Design of BabyIAXO, the intermediate stage towards the International Axion Observatory

Author

Abeln, A., Altenmüller, K., Arguedas Cuendis, S., Armengaud, E., Attié, D., Aune, S., Basso, S., Bergé, L., Biasuzzi, B., Borges De Sousa, P. T. C., Brun, P., Bykovskiy, N., Calvet, D., Carmona, J. M., Castel, J. F., Cebrián, S., Chernov, V., Christensen, F. E., Civitani, M. M., Cogollos, C., Dafní, T., Derbin, A., Desch, K., Díez, D., Dinter, M., Döbrich, B., Drachnev, I., Dudarev, A., Dumoulin, L., Ferreira, D. D. M., Ferrer-Ribas, E., Fleck, I., Galán, J., Gascón, D., Gastaldo, L., Giannotti, M., Giomataris, Y., Giuliani, A., Gninenko, S., Golm, J., Golubev, N., Hagge, L., Hahn, J., Hailey, C. J., Hengstler, D., Henriksen, P. L., Houdy, T., Iglesias-Marzoa, R., Iguaz-Gutierrez, F. J., Irastorza, I. G., Iñiguez, C., Jakovčić, K., Kaminski, J., Kanoute, B., Karstensen, S., Kravchuk, L., Lakić, B., Lasserre, T., Laurent, P., Limousin, O., Lindner, Axel, Loidl, M., Lomskaya, I., López-Alegre, G., Lubsandorzhiev, B., Ludwig, Kai, Luzón, G., Malbrunot, C., Margalejo, C., Marin-Franch, A., Marnieros, S., Marutzky, F., Mauricio, J., Menesguen, Y., Mentink, M., Mertens, S., Mescia, F., Miralda-Escudé, J., Mirallas, H., Mols, J. P., Muratova, V., Navick, X. F., Nones, C., Notari, A., Nozik, A., Obis, L., Oriol, C., Orsini, F., Ortiz De Solórzano, A., Oster, S., Pais Da Silva, H. P., Pantuev, V., Papaevangelou, T., Pareschi, G., Perez, K., Pérez, O., Picatoste, E., Pivovaroff, M. J., Poda, D. V., Redondo, J., Ringwald, A., Rodrigues, M., Rueda-Teruel, F., Rueda-Teruel, S., Ruiz-Choliz, E., Ruz, J., Saemann, E. O., Salvado, J., Schiffer, T., Schmidt, S., Schneekloth, U., Schott, M., Segui, L., Tavecchio, F., Ten Kate, H. H. J., Tkachev, I., Troitsky, S., Unger, D., Unzhakov, E., Ushakov, N., Vogel, J. K., Voronin, D., Weltman, A., Werthenbach, U., Wuensch, W., and Yanes-Díaz, A.

Subjects
7. Clean energy
Abstract

This article describes BabyIAXO, an intermediate experimental stage of the International Axion Observatory (IAXO), proposed to be sited at DESY. IAXO is a large-scale axion helioscope that will look for axions and axion-like particles (ALPs), produced in the Sun, with unprecedented sensitivity. BabyIAXO is conceived to test all IAXO subsystems (magnet, optics and detectors) at a relevant scale for the final system and thus serve as prototype for IAXO, but at the same time as a fully-fledged helioscope with relevant physics reach itself, and with potential for discovery. The BabyIAXO magnet will feature two 10 m long, 70 cm diameter bores, and will host two detection lines (optics and detector) of dimensions similar to the final ones foreseen for IAXO. BabyIAXO will detect or reject solar axions or ALPs with axion-photon couplings down to $g_{a\gamma} \sim 1.5 \times 10^{-11}$ GeV$^{-1}$, and masses up to $m_a\sim 0.25$ eV. BabyIAXO will offer additional opportunities for axion research in view of IAXO, like the development of precision x-ray detectors to identify particular spectral features in the solar axion spectrum, and the implementation of radiofrequency-cavity-based axion dark matter setups.

60. Axion search with BabyIAXO in view of IAXO

Author

Abeln, A., Altenmüller, K., Cuendis, S. Arguedas, Armengaud, E., Attié, D., Aune, S., Basso, S., Bergé, L., Biasuzzi, B., De Sousa, P. T. C. Borges, Brun, P., Bykovskiy, N., Calvet, D., Carmona, J. M., Castel, J. F., Cebrián, S., Chernov, V., Christensen, F. E., Civitani, M. M., Cogollos, C., Dafni, T., Derbin, A., Deschu, K., Díez, D., Dinter, M., Döbrich, B., Drachnev, I., Dudarev, A., Dumoulin, L., Ferreira, D. D. M., Ferrer-Ribas, E., Fleck, I., Galan, Javier, Gascón, D., Gastaldo, L., Giannotti, M., Giomataris, Y., Giuliani, A., Gninenko, S., Golm, J., Golubev, N., Hagge, L., Hahn, J., Hailey, J., Hengstler, D., Henriksen, P. L., Iglesias-Marzoa, R., Iguaz-Gutierrez, F. J., Irastorza, I. G., Iñiguez, C., Jakovcic, K., Kaminski, J., Kanoute, B., Karstensen, S., Kravchuk, L., Lakic, B., Lasserre, T., Laurent, P., Limousin, O., Lindner, A., Loidl, M., Lomskaya, I., López-Alegre, G., Lubsandorzhiev, B., Ludwig, K., Luzón, G., Malbrunot, C., Margalejo, C., Marin-Franch, A., Marnieros, S., Marutzky, F., Mauricio, J., Menesguen, Y., Mentink, M., Mescia, F., Miralda-Escudé, J., Mirallas, H., Mols, J. P., Muratova, V., Navick, X. F., Nones, C., Notari, A., Nozik, A., Obis, L., Oriol, C., Orsini, F., Ortiz De Solórzano, A., Oster, S., Pais Da Silva, H. P., Pantuev, V., Papaevangelou, T., Pareschi, G., Perez, K., Pérez, O., Picatoste, E., Pivovaroff, M. J., Poda, D. V., Redondo, J., Ringwald, A., Rodrigues, M., Rueda-Teruel, F., Rueda-Teruel, S., Ruiz-Choliz, E., Ruz, J., Saemann, E. O., Salvado, J., Schiffer, T., Schmidt, S., Schneekloth, U., Schott, M., Segui, L., Tavecchio, F., Ten Kate, H. H. J., Tkachev, I., Troitsky, S., Unger, D., Unzhakov, E., Ushakov, N., Vogel, J. K., Voronin, D., Weltman, A., Werthenbach, U., Wuensch, W., and Yanes-Díaz, A.

Subjects
experimental methods, axion: solar, IAXO, 7. Clean energy, activity report, detector: design
Abstract

Axions are a natural consequence of the Peccei-Quinn mechanism, the most compelling solution to the strong-CP problem. Similar axion-like particles (ALPs) also appear in a number of possible extensions of the Standard Model, notably in string theories. Both axions and ALPs are very well motivated candidates for Dark Matter, and in addition, they would be copiously produced at the sun's core. A relevant effort during the last decade has been the CAST experiment at CERN, the most sensitive axion helioscope to-date. The International Axion Observatory (IAXO) is a large-scale 4th generation helioscope. As its primary physics goal, IAXO will look for solar axions or ALPs with a signal to background ratio of about 5 orders of magnitude higher than CAST. Recently the IAXO collaboration has proposed and intermediate experimental stage, BabyIAXO, conceived to test all IAXO subsystems (magnet, optics, detectors and sun-tracking systems) at a relevant scale for the final system and thus serve as pathfinder for IAXO but at the same time as a fully-fledged helioscope with record and relevant physics reach in itself with potential for discovery. BabyIAXO was endorsed by the Physics Review committee of DESY last May 2019. Here we will review the status and prospects of BabyIAXO and its potential to probe the most physics motivated regions of the axion & ALPs parameter space.

61. Conceptual design of BabyIAXO, the intermediate stage towards the International Axion Observatory

Author

Abeln, A., Altenm��ller, K., Arguedas Cuendis, S., Armengaud, E., Atti��, D., Aune, S., Basso, S., Berg��, L., Biasuzzi, B., Borges De Sousa, P. T. C., Brun, P., Bykovskiy, N., Calvet, D., Carmona, J. M., Castel, J. F., Cebri��n, S., Chernov, V., Christensen, F. E., Civitani, M. M., Cogollos, C., Dafn��, T., Derbin, A., Desch, K., D��ez, D., Dinter, M., D��brich, B., Drachnev, I., Dudarev, A., Dumoulin, L., Ferreira, D. D. M., Ferrer-Ribas, E., Fleck, I., Gal��n, J., Gasc��n, D., Gastaldo, L., Giannotti, M., Giomataris, Y., Giuliani, A., Gninenko, S., Golm, J., Golubev, N., Hagge, L., Hahn, J., Hailey, C. J., Hengstler, D., Henriksen, P. L., Houdy, T., Iglesias-Marzoa, R., Iguaz, F. J., Irastorza, I. G., I��iguez, C., Jakov��i��, K., Kaminski, J., Kanoute, B., Karstensen, S., Kravchuk, L., Laki��, B., Lasserre, T., Laurent, P., Limousin, O., Lindner, A., Loidl, M., Lomskaya, I., L��pez-Alegre, G., Lubsandorzhiev, B., Ludwig, K., Luz��n, G., Malbrunot, C., Margalejo, C., Marin-Franch, A., Marnieros, S., Marutzky, F., Mauricio, J., Menesguen, Y., Mentink, M., Mertens, S., Mescia, F., Miralda-Escud��, J., Mirallas, H., Mols, J. P., Muratova, V., Navick, X. F., Nones, C., Notari, A., Nozik, A., Obis, L., Oriol, C., Orsini, F., Ortiz de Sol��rzano, A., Oster, S., Pais Da Silva, H. P., Pantuev, V., Papaevangelou, T., Pareschi, G., Perez, K., P��rez, O., Picatoste, E., Pivovaroff, M. J., Poda, D. V., Redondo, J., Ringwald, A., Rodrigues, M., Rueda-Teruel, F., Rueda-Teruel, S., Ruiz-Choliz, E., Ruz, J., Saemann, E. O., Salvado, J., Schiffer, T., Schmidt, S., Schneekloth, U., Schott, M., Segui, L., Tavecchio, F., ten Kate, H. H. J., Tkachev, I., Troitsky, S., Unger, D., Unzhakov, E., Ushakov, N., Vogel, J. K., Voronin, D., Weltman, A., Werthenbach, U., Wuensch, W., and Yanes-D��az, A.

Subjects
axion: dark matter, CP violation, Beyond Standard Model, Dark matter, axion-like particles, Other experiments, axion: solar, IAXO, sensitivity, 7. Clean energy, optics, detector: design
Abstract

Journal of high energy physics 05(5), 137 (2021). doi:10.1007/JHEP05(2021)137, This article describes BabyIAXO, an intermediate experimental stage of the International Axion Observatory (IAXO), proposed to be sited at DESY. IAXO is a large-scale axion helioscope that will look for axions and axion-like particles (ALPs), produced in the Sun, with unprecedented sensitivity. BabyIAXO is conceived to test all IAXO subsystems (magnet, optics and detectors) at a relevant scale for the final system and thus serve as prototype for IAXO, but at the same time as a fully-fledged helioscope with relevant physics reach itself, and with potential for discovery. The BabyIAXO magnet will feature two 10 m long, 70 cm diameter bores, and will host two detection lines (optics and detector) of dimensions similar to the final ones foreseen for IAXO. BabyIAXO will detect or reject solar axions or ALPs with axion-photon couplings down to g$_{a��}$ ��� 1.5 �� 10$^{���11}$ GeV$^{���1}$, and masses up to m$_{a}$ ��� 0.25 eV. BabyIAXO will offer additional opportunities for axion research in view of IAXO, like the development of precision x-ray detectors to identify particular spectral features in the solar axion spectrum, and the implementation of radiofrequency-cavity-based axion dark matter setups.[graphic not available: see fulltext], Published by SISSA, [Trieste]

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