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458 results on '"He, Lifeng"'

62. Dynamic deformation evolution of the adiabatic shear bands in zirconium alloy formed at a strain rate of about 2300 s-1

Author

Zou Dongli, Xiao Dawu, Lu Chao, He Lifeng, and Zhao Yawen

Subjects
Physics, QC1-999
Abstract

Deformed microstructure of the adiabatic shear bands in zirconium alloy impacted by split Hopkinson pressure bar at a strain rate of about 2300 s-1 was characterized systemically. Four different strains of zirconium alloy subjected to impact loading at same strain rate were designed by means of strain stopper rings. At a strain of 0.30, the transformed bands were distinguished at the tip of crack. The transformed bands mainly composed of the ultrafine and equiaxed grains with the mean diameter of about 100~300 nm were found by a dual beam FIB/TEM system. Besides ultrafine grains in the transformed bands, nanometer fine grain was observed and confirmed by HRTEM. Thus, the transformed bands mainly composed of the mixed microstructure including nanometer and ultrafine grains were confirmed, and n phase transformation and amorphization in transformed bands take place.

Published
2018
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63. Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma

Author

Fan, Xiaoxiao, Jin, Shengxi, Li, Yirun, Khadaroo, Parikshit Asutosh, Dai, Yili, He, Lifeng, Zhou, Daizhan, and Lin, Hui

Subjects
genetic alterations, epigenetic alterations, E-cadherin, Review, HCC
Abstract

E-cadherin is well known as a growth and invasion suppressor and belongs to the large cadherin family. Loss of E-cadherin is widely known as the hallmark of epithelial-to-mesenchymal transition (EMT) with the involvement of transcription factors such as Snail, Slug, Twist and Zeb1/2. Tumor cells undergoing EMT could migrate to distant sites and become metastases. Recently, numerous studies have revealed how the expression of E-cadherin is regulated by different kinds of genetic and epigenetic alteration, which are implicated in several crucial transcription factors and pathways. E-cadherin signaling plays an important role in hepatocellular carcinoma (HCC) initiation and progression considering the highly mutated frequency of CTNNB1 (27%). Combining the data from The Cancer Genome Atlas (TCGA) database and previous studies, we have summarized the roles of gene mutations, chromosome instability, DNA methylation, histone modifications and non-coding RNA in E-cadherin in HCC. In this review, we discuss the current understanding of the relationship between these modifications and HCC. Perspectives on E-cadherin-related research in HCC are provided.

Published
2019

72. Central Asian countries

Author

Xu Shaoshi, Jing Chaoyang, Wang Xiaotao, Hu Qiaoye, Ao Wanzhong, He Lifeng, and Ning Jizhe

Subjects
Development economics, Asian country, Psychology
Published
2020
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76. South Asian countries

Author

He Lifeng, Jing Chaoyang, Hu Qiaoye, Ao Wanzhong, Wang Xiaotao, Ning Jizhe, and Xu Shaoshi

Subjects
South asia, Economics, Socioeconomics
Published
2020
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79. Northeast Asian countries

Author

Ning Jizhe, Ao Wanzhong, Xu Shaoshi, Jing Chaoyang, Hu Qiaoye, He Lifeng, and Wang Xiaotao

Subjects
Geography, Asian country, Socioeconomics
Published
2020
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80. Southeast Asian countries

Author

Ao Wanzhong, Hu Qiaoye, Ning Jizhe, Jing Chaoyang, Xu Shaoshi, He Lifeng, and Wang Xiaotao

Subjects
Business, Socioeconomics, Southeast asian
Published
2020
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81. Other countries

Author

Xu Shaoshi, He Lifeng, Ning Jizhe, Wang Xiaotao, Jing Chaoyang, Ao Wanzhong, and Hu Qiaoye

Published
2020
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