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65. Supplementary_Information_JTE – Supplemental material for Osteogenic potential of poly(ethylene glycol)-amorphous calcium phosphate composites on human mesenchymal stem cells

Author

Chahal, Aman S, Schweikle, Manuel, Aina-Mari Lian, Reseland, Janne E, Haugen, Håvard J, and Tiainen, Hanna

Subjects
110599 Dentistry not elsewhere classified, FOS: Clinical medicine, FOS: Biological sciences, 69999 Biological Sciences not elsewhere classified
Abstract

Supplemental material, Supplementary_Information_JTE for Osteogenic potential of poly(ethylene glycol)-amorphous calcium phosphate composites on human mesenchymal stem cells by Aman S Chahal, Manuel Schweikle, Aina-Mari Lian, Janne E Reseland, Håvard J Haugen and Hanna Tiainen in Journal of Tissue Engineering

Published
2020
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69. Biomaterials and regenerative technologies used in bone regeneration in the craniomaxillofacial region: Consensus report of group 2 of the 15th European Workshop on Periodontology on Bone Regeneration

Author

Sanz, Mariano, primary, Dahlin, Christer, additional, Apatzidou, Danae, additional, Artzi, Zvi, additional, Bozic, Darko, additional, Calciolari, Elena, additional, De Bruyn, Hugo, additional, Dommisch, Henrik, additional, Donos, Nikos, additional, Eickholz, Peter, additional, Ellingsen, Jan E., additional, Haugen, Håvard J., additional, Herrera, David, additional, Lambert, France, additional, Layrolle, Pierre, additional, Montero, Eduardo, additional, Mustafa, Kamal, additional, Omar, Omar, additional, and Schliephake, Henning, additional

Published
2019
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70. Sodium alendronate loaded poly(l-lactide- co-glycolide) microparticles immobilized on ceramic scaffolds for local treatment of bone defects.

Author

Rumian, Łucja, Wolf-Brandstetter, Cornelia, Rößler, Sina, Reczyńska, Katarzyna, Tiainen, Hanna, Haugen, Håvard J, Scharnweber, Dieter, and Pamuła, Elżbieta

Subjects
ALENDRONATE, TITANIUM dioxide, BIOCOMPATIBILITY, OSTEOPOROSIS, BONE remodeling
Abstract

Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and healing. Sodium alendronate (Aln), a widely used anti-osteoporosis drug, exhibits strong inhibitory effect on bone resorption performed by osteoclasts. Thus, we propose a new approach for the treatment of bone defects in craniofacial region combining biocompatible titanium dioxide scaffolds and poly(l -lactide- co -glycolide) microparticles (MPs) loaded with Aln. The MPs were effectively attached to the surface of the scaffolds' pore walls by human recombinant collagen. Drug release from the scaffolds was characterized by initial burst (24 ± 6% of the drug released within first 24 h) followed by a sustained release phase (on average 5 µg of Aln released per day from Day 3 to Day 18). In vitro tests evidenced that Aln at concentrations of 5 and 2.5 µg/ml was not cytotoxic for MG-63 osteoblast-like cells (viability between 81 ± 6% and 98 ± 3% of control), but it prevented RANKL-induced formation of osteoclast-like cells from macrophages derived from peripheral blood mononuclear cells, as shown by reduced fusion capability and decreased tartrate-resistant acid phosphatase 5b activity (56 ± 5% reduction in comparison to control after 8 days of culture). Results show that it is feasible to design the scaffolds providing required doses of Aln inhibiting osteoclastogenesis, reducing osteoclast activity, but not affecting osteoblast functions, which may be beneficial in the treatment of critical-size bone tissue defects. [ABSTRACT FROM AUTHOR]

Published
2021
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78. The influence of sintering conditions on microstructure and mechanical properties of titanium dioxide scaffolds for the treatment of bone tissue defects

Author

Rumian, Łucja, Reczyńska, Katarzyna, Wrona, Małgorzata, Tiainen, Hanna, Haugen, Håvard J., and Pamuła, Elżbieta

Subjects
ceramic scaffolds, porosity, titanium dioxide, bone tissue engineering, mechanical properties, polymer sponge replication
Abstract

Acta of Bioengineering and Biomechanics; 01/2015; ISSN 1509-409X

Published
2015
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79. Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds

Author

Pullisaar, Helen, Verket, Anders, Szoke, Krisztina, Tiainen, Hanna, Haugen, Håvard J, Brinchmann, Jan E, Reseland, Janne E, and Østrup, Esben

Subjects
primary human osteoblasts, alginate hydrogel, TiO2 scaffold, human adipose tissue–derived mesenchymal stem cells, Original Article, Enamel matrix derivative
Abstract

The purpose of bone tissue engineering is to employ scaffolds, cells, and growth factors to facilitate healing of bone defects. The aim of this study was to assess the viability and osteogenic differentiation of primary human osteoblasts and adipose tissue-derived mesenchymal stem cells from various donors on titanium dioxide (TiO2) scaffolds coated with an alginate hydrogel enriched with enamel matrix derivative. Cells were harvested for quantitative reverse transcription polymerase chain reaction on days 14 and 21, and medium was collected on days 2, 14, and 21 for protein analyses. Neither coating with alginate hydrogel nor alginate hydrogel enriched with enamel matrix derivative induced a cytotoxic response. Enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative. The alginate hydrogel coating procedure may have potential for local delivery of enamel matrix derivative and other stimulatory factors for use in bone tissue engineering.

Published
2015

83. Development of an implant to treat gastro-oesophageal reflux disease

Author

Haugen, Håvard J., Wintermantel, Erich (Prof. Dr. Dr. habil.), Stichlmair, Johann (Prof. Dr. habil.), and Feussner, Hubertus A. E. J. (Prof. Dr. habil.)

Subjects
GÖRD, porös, Sterilization, gamma Sterilization, Spritzgussmaschine, Heisspresse, MDA, Abbau, enzymatischer Abbau, biokompatibilität, GORD, Implant, sterilisation, gamma sterilisation, enzymatic degradation, methyl dianiline, porous, foaming process, injection moulding, hot pressing, biocompatible, ddc:680, Fertigung von Produkten für bestimmte Verwendungszwecke, Medizin, ddc:610, ddc:620, Ingenieurswissenschaften
Abstract

This study introduces a new method for producing a ring shaped polymer implant, which is to be placed around the oesophagus and passively support the sphincter. This support should reduce the amount of gastric juices in the oesophagus for patients with reflux and hence heal the oesophagitis. Previously, such implants were applied, but failed due to migration along the oesophagus. The idea was to produce an implant with a porous structure, in which tissue could attach to and grow into. This would prevent implant migration. It has been proven that it was possible to produce the desired porous structure on two different industrial polymer production machine hot pressing and injection moulding, with the novel technique of using water as a foaming agent. The porous structure was adjustable upon the processing parameters. This method was utilized to produce a gastro-oesophageal reflux disease (GORD) implant with a defined pore size distribution. The biocompatible properties of the material were not greatly altered through the new processing method. Biocompatible tests and enzymatic degradation studies have proven that the injection moulded GORD samples performed better. Enzyme degradation products were found to lay within toxic levels for both machineries. By applying injection moulding process one is also capable of producing far more implants per unit time compared to hot pressing. Material analysis and cell toxicity tests revealed that the most desirable sterilisation method was γ-sterilisation with a minimum dose of 25 kGy. The biocompatibility of the implant was improved by increasing radiation dose, as residual monomers were bound back into the polymer chain. The concentration of methylene dianiline (MDA) was measured to be four times higher for steam sterilisation compared to gamma irradiation of 10 kGy. MDA was undetectable at higher irradiation doses. In dieser Studie wurde eine neue Methode zur Produktion von ringförmigen Implantaten entwickelt. Dieses Implantat soll Patienten, die an der gastroösophagealen Reflux-Krankheit der Speiseröhre leiden, in einem minimal-invasiven Eingriff um die Speiseröhre gelegt werden, um damit passiv den Speiseröhren-Schließmuskel zu unterstützen. Die Menge der Magensäfte in der Speiseröhre soll damit verringert werden und die Reflux-Krankheit könnte geheilt werden. Frühere Implantate, die ebenfalls um die Speiseröhre positioniert wurden, sind jedoch entlang der Speiseröhre verrutscht. Diese Dislokation könnte dadurch verhindert werden, dass Speiseröhrengewebe in das Implantat hineinwächst. Dafür ist eine poröse Innenschicht notwendig. Es ist gelungen, die gewünschte poröse Struktur und Prototypen des Implantates herzustellen. Dabei wurden eine Heißpresse bzw. eine Spritzgussmaschine verwendet. Die Porengröße und Porosität waren dabei mit den jeweiligen Prozess-Parametern einstellbar. Die biokompatiblen Eigenschaften des Materials wurden nicht entscheidend durch die neue Methode geändert. Das spritzgegossene Implantat zeigte höher Biokompatiblitätswerte und waren in einem enzymatischen Abbaustudium beständiger als die von der Heißpresse hergestellten Proben. Es konnten innerhalb der Toxitätsgrenze keine Abbauprodukte nachgewiesen werden. Verschiedene Sterilisations-verfahrens hatten keine messbaren Auswirkungen auf den Werkstoff, jedoch waren Abweichungen in der Zelltoxizität zu beobachten. Dampfsterilisierte Proben wiesen ein geringes Zellwachstum auf, während auf γ-sterilisierten Proben mit steigender Strahlungsdosis ein erhöhtes Zellwachstum nachgewiesen werden konnte. Generell konnten Fibroblasten an das Material adherieren und proliferieren.

Published
2007

84. Regulatory Loops Consisting of Transcription Factors and microRNA Species Determine the Mineralizing Characteristics of Cell Phenotypes — Implications for Bone Engineering and Prevention of Soft Tissue Mineralization

Author

Gordeladze, Jan O., Stakkestad, Øystein, Haugen, Sigrid, Reseland, Janne E., Syversen, Unni, Johnsen, Gaute F., Haugen, Håvard J., Lyngstadaas, Ståle P., Møller, Mona, Valtieri, Mauro, Gordeladze, Jan O., Stakkestad, Øystein, Haugen, Sigrid, Reseland, Janne E., Syversen, Unni, Johnsen, Gaute F., Haugen, Håvard J., Lyngstadaas, Ståle P., Møller, Mona, and Valtieri, Mauro

Published
2014
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88. Development of an implant to treat gastro-oesophageal reflux disease

Author

Wintermantel, Erich (Prof. Dr. Dr. habil.), Feussner, Hubertus A. E. J. (Prof. Dr. habil.), Stichlmair, Johann (Prof. Dr. habil.), Haugen, Håvard J., Wintermantel, Erich (Prof. Dr. Dr. habil.), Feussner, Hubertus A. E. J. (Prof. Dr. habil.), Stichlmair, Johann (Prof. Dr. habil.), and Haugen, Håvard J.

Abstract

This study introduces a new method for producing a ring shaped polymer implant, which is to be placed around the oesophagus and passively support the sphincter. This support should reduce the amount of gastric juices in the oesophagus for patients with reflux and hence heal the oesophagitis. Previously, such implants were applied, but failed due to migration along the oesophagus. The idea was to produce an implant with a porous structure, in which tissue could attach to and grow into. This would prevent implant migration. It has been proven that it was possible to produce the desired porous structure on two different industrial polymer production machine hot pressing and injection moulding, with the novel technique of using water as a foaming agent. The porous structure was adjustable upon the processing parameters. This method was utilized to produce a gastro-oesophageal reflux disease (GORD) implant with a defined pore size distribution. The biocompatible properties of the material were not greatly altered through the new processing method. Biocompatible tests and enzymatic degradation studies have proven that the injection moulded GORD samples performed better. Enzyme degradation products were found to lay within toxic levels for both machineries. By applying injection moulding process one is also capable of producing far more implants per unit time compared to hot pressing. Material analysis and cell toxicity tests revealed that the most desirable sterilisation method was γ-sterilisation with a minimum dose of 25 kGy. The biocompatibility of the implant was improved by increasing radiation dose, as residual monomers were bound back into the polymer chain. The concentration of methylene dianiline (MDA) was measured to be four times higher for steam sterilisation compared to gamma irradiation of 10 kGy. MDA was undetectable at higher irradiation doses., In dieser Studie wurde eine neue Methode zur Produktion von ringförmigen Implantaten entwickelt. Dieses Implantat soll Patienten, die an der gastroösophagealen Reflux-Krankheit der Speiseröhre leiden, in einem minimal-invasiven Eingriff um die Speiseröhre gelegt werden, um damit passiv den Speiseröhren-Schließmuskel zu unterstützen. Die Menge der Magensäfte in der Speiseröhre soll damit verringert werden und die Reflux-Krankheit könnte geheilt werden. Frühere Implantate, die ebenfalls um die Speiseröhre positioniert wurden, sind jedoch entlang der Speiseröhre verrutscht. Diese Dislokation könnte dadurch verhindert werden, dass Speiseröhrengewebe in das Implantat hineinwächst. Dafür ist eine poröse Innenschicht notwendig. Es ist gelungen, die gewünschte poröse Struktur und Prototypen des Implantates herzustellen. Dabei wurden eine Heißpresse bzw. eine Spritzgussmaschine verwendet. Die Porengröße und Porosität waren dabei mit den jeweiligen Prozess-Parametern einstellbar. Die biokompatiblen Eigenschaften des Materials wurden nicht entscheidend durch die neue Methode geändert. Das spritzgegossene Implantat zeigte höher Biokompatiblitätswerte und waren in einem enzymatischen Abbaustudium beständiger als die von der Heißpresse hergestellten Proben. Es konnten innerhalb der Toxitätsgrenze keine Abbauprodukte nachgewiesen werden. Verschiedene Sterilisations-verfahrens hatten keine messbaren Auswirkungen auf den Werkstoff, jedoch waren Abweichungen in der Zelltoxizität zu beobachten. Dampfsterilisierte Proben wiesen ein geringes Zellwachstum auf, während auf γ-sterilisierten Proben mit steigender Strahlungsdosis ein erhöhtes Zellwachstum nachgewiesen werden konnte. Generell konnten Fibroblasten an das Material adherieren und proliferieren.

Published
2007

93. Enzymatically induced mineralization of platelet‐rich fibrin

Author

Douglas, Timothy E. L., primary, Gassling, Volker, additional, Declercq, Heidi A., additional, Purcz, Nicolai, additional, Pamula, Elzbieta, additional, Haugen, Håvard J., additional, Chasan, Safak, additional, de Mulder, Eric L. W., additional, Jansen, John A., additional, and Leeuwenburgh, Sander C. G., additional

Published
2012
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100. CROSSLINKING DENSITY OF EXPERIMENTAL DENTAL COMPOSITES WITH COPPER-DOPED MESOPOROUS BIOACTIVE NANOSPHERES.

Author

Bota, Maria, Tarle, Frano, Par, Matej, Haugen, Håvard J., Kai Zheng, Boccaccini, Aldo R., and Marovic, Danijela

Subjects
DENTAL materials, DOPING agents (Chemistry), MECHANICAL behavior of materials, POLYMER networks, BIOACTIVE glasses
Abstract

Aim: Copper-doped mesoporous bioactive nanospheres (Cu-MBGN) were developed to prevent secondary caries by imparting antimicrobial and ion-releasing/remineralizing properties to experimental composites. The crosslinking density of the polymer network determines the material's mechanical properties, residual monomer release and durability. In this study, we aimed to investigate whether Cu-MBGN affects the crosslink density of the polymer network using the ethanol softening test. Materials and Methods: Seven experimental composites were prepared containing 1, 5, or 10 wt% Cu-MBGN and the corresponding inert controls (silica) and bioactive controls (bioactive glass 45S5). The resin matrix consisted of 35 wt% BisGMA/TEGDMA and 51-55 wt% barium glass microfillers. Cylindrical samples (n=5; h=2 mm, d=6 mm) were photopolymerized at 700 mW/cm2 for 2x20 s and dark stored at 37°C. After polishing, Vickers microhardness (HV; 100 g load, 15 s dwell time) was measured at 5 positions/sample and before and after storage in absolute ethanol for 7 days in the dark at 37°C. One-way analysis ANOVA and Tukey's post hoc test (p<0.05) were used for statistical analysis. Results: Composites containing Cu-MBGN had the highest HV both before and after ethanol storage (61.2-50.6 VHN), while bioactive controls containing 10 or 15 wt% 45S5 had the lowest HV (40.6-35.2 VHN). Ethanol storage decreased HV the most for the inert control materials (12.5% and 10.4% decrease), followed by the material containing 10% Cu-MBGN, which had 8% lower HV values. However, there was no statistically significant difference between the materials in the before/after ratio. Materials with 1 and 5 wt% Cu-MBGN had the lowest HV decrease (6.2 and 5.5%, respectively) and the highest absolute HV values before and after ethanol softening. Conclusion: Composite with 5 wt% Cu-MBGN in combination with nanosilica fillers exhibited the lowest ethanol softening, indicating the polymer's highest durability and crosslinking density. [ABSTRACT FROM AUTHOR]

Published
2022

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