88 results on '"Harford, E"'
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52. Overview of JET results for optimising ITER operation
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J. Mailloux, N. Abid, K. Abraham, P. Abreu, O. Adabonyan, P. Adrich, V. Afanasev, M. Afzal, T. Ahlgren, L. Aho-Mantila, N. Aiba, M. Airila, M. Akhtar, R. Albanese, M. Alderson-Martin, D. Alegre, S. Aleiferis, A. Aleksa, A.G. Alekseev, E. Alessi, P. Aleynikov, J. Algualcil, M. Ali, M. Allinson, B. Alper, E. Alves, G. Ambrosino, R. Ambrosino, V. Amosov, E.Andersson Sundén, P. Andrew, B.M. Angelini, C. Angioni, I. Antoniou, L.C. Appel, C. Appelbee, S. Aria, M. Ariola, G. Artaserse, W. Arter, V. Artigues, N. Asakura, A. Ash, N. Ashikawa, V. Aslanyan, M. Astrain, O. Asztalos, D. Auld, F. Auriemma, Y. Austin, L. Avotina, E. Aymerich, A. Baciero, F. Bairaktaris, J. Balbin, L. Balbinot, I. Balboa, M. Balden, C. Balshaw, N. Balshaw, V.K. Bandaru, J. Banks, Yu.F. Baranov, C. Barcellona, A. Barnard, M. Barnard, R. Barnsley, A. Barth, M. Baruzzo, S. Barwell, M. Bassan, A. Batista, P. Batistoni, L. Baumane, B. Bauvir, L. Baylor, P.S. Beaumont, D. Beckett, A. Begolli, M. Beidler, N. Bekris, M. Beldishevski, E. Belli, F. Belli, É. Belonohy, M. Ben Yaala, J. Benayas, J. Bentley, H. Bergsåker, J. Bernardo, M. Bernert, M. Berry, L. Bertalot, H. Betar, M. Beurskens, S. Bickerton, B. Bieg, J. Bielecki, A. Bierwage, T. Biewer, R. Bilato, P. Bílková, G. Birkenmeier, H. Bishop, J.P.S. Bizarro, J. Blackburn, P. Blanchard, P. Blatchford, V. Bobkov, A. Boboc, P. Bohm, T. Bohm, I. Bolshakova, T. Bolzonella, N. Bonanomi, D. Bonfiglio, X. Bonnin, P. Bonofiglo, S. Boocock, A. Booth, J. Booth, D. Borba, D. Borodin, I. Borodkina, C. Boulbe, C. Bourdelle, M. Bowden, K. Boyd, I.Božičević Mihalić, S.C. Bradnam, V. Braic, L. Brandt, R. Bravanec, B. Breizman, A. Brett, S. Brezinsek, M. Brix, K. Bromley, B. Brown, D. Brunetti, R. Buckingham, M. Buckley, R. Budny, J. Buermans, H. Bufferand, P. Buratti, A. Burgess, A. Buscarino, A. Busse, D. Butcher, E.de la Cal, G. Calabrò, L. Calacci, R. Calado, Y. Camenen, G. Canal, B. Cannas, M. Cappelli, S. Carcangiu, P. Card, A. Cardinali, P. Carman, D. Carnevale, M. Carr, D. Carralero, L. Carraro, I.S. Carvalho, P. Carvalho, I. Casiraghi, F.J. Casson, C. Castaldo, J.P. Catalan, N. Catarino, F. Causa, M. Cavedon, M. Cecconello, C.D. Challis, B. Chamberlain, C.S. Chang, A. Chankin, B. Chapman, M. Chernyshova, A. Chiariello, P. Chmielewski, A. Chomiczewska, L. Chone, G. Ciraolo, D. Ciric, J. Citrin, Ł. Ciupinski, M. Clark, R. Clarkson, C. Clements, M. Cleverly, J.P. Coad, P. Coates, A. Cobalt, V. Coccorese, R. Coelho, J.W. Coenen, I.H. Coffey, A. Colangeli, L. Colas, C. Collins, J. Collins, S. Collins, D. Conka, S. Conroy, B. Conway, N.J. Conway, D. Coombs, P. Cooper, S. Cooper, C. Corradino, G. Corrigan, D. Coster, P. Cox, T. Craciunescu, S. Cramp, C. Crapper, D. Craven, R. Craven, M.Crialesi Esposito, G. Croci, D. Croft, A. Croitoru, K. Crombé, T. Cronin, N. Cruz, C. Crystal, G. Cseh, A. Cufar, A. Cullen, M. Curuia, T. Czarski, H. Dabirikhah, A.Dal Molin, E. Dale, P. Dalgliesh, S. Dalley, J. Dankowski, P. David, A. Davies, S. Davies, G. Davis, K. Dawson, S. Dawson, I.E. Day, M. De Bock, G. De Temmerman, G. De Tommasi, K. Deakin, J. Deane, R. Dejarnac, D. Del Sarto, E. Delabie, D. Del-Castillo-Negrete, A. Dempsey, R.O. Dendy, P. Devynck, A. Di Siena, C. Di Troia, T. Dickson, P. Dinca, T. Dittmar, J. Dobrashian, R.P. Doerner, A.J.H. Donné, S. Dorling, S. Dormido-Canto, D. Douai, S. Dowson, R. Doyle, M. Dreval, P. Drewelow, P. Drews, G. Drummond, Ph. Duckworth, H. Dudding, R. Dumont, P. Dumortier, D. Dunai, T. Dunatov, M. Dunne, I. Ďuran, F. Durodié, R. Dux, A. Dvornova, R. Eastham, J. Edwards, Th. Eich, A. Eichorn, N. Eidietis, A. Eksaeva, H. El Haroun, G. Ellwood, C. Elsmore, O. Embreus, S. Emery, G. Ericsson, B. Eriksson, F. Eriksson, J. Eriksson, L.G. Eriksson, S. Ertmer, S. Esquembri, A.L. Esquisabel, T. Estrada, G. Evans, S. Evans, E. Fable, D. Fagan, M. Faitsch, M. Falessi, A. Fanni, A. Farahani, I. Farquhar, A. Fasoli, B. Faugeras, S. Fazinić, F. Felici, R. Felton, A. Fernandes, H. Fernandes, J. Ferrand, D.R. Ferreira, J. Ferreira, G. Ferrò, J. Fessey, O. Ficker, A.R. Field, A. Figueiredo, J. Figueiredo, A. Fil, N. Fil, P. Finburg, D. Fiorucci, U. Fischer, G. Fishpool, L. Fittill, M. Fitzgerald, D. Flammini, J. Flanagan, K. Flinders, S. Foley, N. Fonnesu, M. Fontana, J.M. Fontdecaba, S. Forbes, A. Formisano, T. Fornal, L. Fortuna, E. Fortuna-Zalesna, M. Fortune, C. Fowler, E. Fransson, L. Frassinetti, M. Freisinger, R. Fresa, R. Fridström, D. Frigione, T. Fülöp, M. Furseman, V. Fusco, S. Futatani, D. Gadariya, K. Gál, D. Galassi, K. Gałązka, S. Galeani, D. Gallart, R. Galvão, Y. Gao, J. Garcia, M. García-Muñoz, M. Gardener, L. Garzotti, J. Gaspar, R. Gatto, P. Gaudio, D. Gear, T. Gebhart, S. Gee, M. Gelfusa, R. George, S.N. Gerasimov, G. Gervasini, M. Gethins, Z. Ghani, M. Gherendi, F. Ghezzi, J.C. Giacalone, L. Giacomelli, G. Giacometti, C. Gibson, K.J. Gibson, L. Gil, A. Gillgren, D. Gin, E. Giovannozzi, C. Giroud, R. Glen, S. Glöggler, J. Goff, P. Gohil, V. Goloborodko, R. Gomes, B. Gonçalves, M. Goniche, A. Goodyear, S. Gore, G. Gorini, T. Görler, N. Gotts, R. Goulding, E. Gow, B. Graham, J.P. Graves, H. Greuner, B. Grierson, J. Griffiths, S. Griph, D. Grist, W. Gromelski, M. Groth, R. Grove, M. Gruca, D. Guard, N. Gupta, C. Gurl, A. Gusarov, L. Hackett, S. Hacquin, R. Hager, L. Hägg, A. Hakola, M. Halitovs, S. Hall, S.A. Hall, S. Hallworth-Cook, C.J. Ham, D. Hamaguchi, M. Hamed, C. Hamlyn-Harris, K. Hammond, E. Harford, J.R. Harrison, D. Harting, Y. Hatano, D.R. Hatch, T. Haupt, J. Hawes, N.C. Hawkes, J. Hawkins, T. Hayashi, S. Hazael, S. Hazel, P. Heesterman, B. Heidbrink, W. Helou, O. Hemming, S.S. Henderson, R.B. Henriques, D. Hepple, J. Herfindal, G. Hermon, J. Hill, J.C. Hillesheim, K. Hizanidis, A. Hjalmarsson, A. Ho, J. Hobirk, O. Hoenen, C. Hogben, A. Hollingsworth, S. Hollis, E. Hollmann, M. Hölzl, B. Homan, M. Hook, D. Hopley, J. Horáček, D. Horsley, N. Horsten, A. Horton, L.D. Horton, L. Horvath, S. Hotchin, R. Howell, Z. Hu, A. Huber, V. Huber, T. Huddleston, G.T.A. Huijsmans, P. Huynh, A. Hynes, M. Iliasova, D. Imrie, M. Imríšek, J. Ingleby, P. Innocente, K. Insulander Björk, N. Isernia, I. Ivanova-Stanik, E. Ivings, S. Jablonski, S. Jachmich, T. Jackson, P. Jacquet, H. Järleblad, F. Jaulmes, J.Jenaro Rodriguez, I. Jepu, E. Joffrin, R. Johnson, T. Johnson, J. Johnston, C. Jones, G. Jones, L. Jones, N. Jones, T. Jones, A. Joyce, R. Juarez, M. Juvonen, P. Kalniņa, T. Kaltiaisenaho, J. Kaniewski, A. Kantor, A. Kappatou, J. Karhunen, D. Karkinsky, Yu Kashchuk, M. Kaufman, G. Kaveney, Ye.O. Kazakov, V. Kazantzidis, D.L. Keeling, R. Kelly, M. Kempenaars, C. Kennedy, D. Kennedy, J. Kent, K. Khan, E. Khilkevich, C. Kiefer, J. Kilpeläinen, C. Kim, Hyun-Tae Kim, S.H. Kim, D.B. King, R. King, D. Kinna, V.G. Kiptily, A. Kirjasuo, K.K. Kirov, A. Kirschner, T. kiviniemi, G. Kizane, M. Klas, C. Klepper, A. Klix, G. Kneale, M. Knight, P. Knight, R. Knights, S. Knipe, M. Knolker, S. Knott, M. Kocan, F. Köchl, I. Kodeli, Y. Kolesnichenko, Y. Kominis, M. Kong, V. Korovin, B. Kos, D. Kos, H.R. Koslowski, M. Kotschenreuther, M. Koubiti, E. Kowalska-Strzęciwilk, K. Koziol, A. Krasilnikov, V. Krasilnikov, M. Kresina, K. Krieger, N. Krishnan, A. Krivska, U. Kruezi, I. Książek, A.B. Kukushkin, H. Kumpulainen, T. Kurki-Suonio, H. Kurotaki, S. Kwak, O.J. Kwon, L. Laguardia, E. Lagzdina, A. Lahtinen, A. Laing, N. Lam, H.T. Lambertz, B. Lane, C. Lane, E.Lascas Neto, E. Łaszyńska, K.D. Lawson, A. Lazaros, E. Lazzaro, G. Learoyd, Chanyoung Lee, S.E. Lee, S. Leerink, T. Leeson, X. Lefebvre, H.J. Leggate, J. Lehmann, M. Lehnen, D. Leichtle, F. Leipold, I. Lengar, M. Lennholm, E. Leon Gutierrez, B. Lepiavko, J. Leppänen, E. Lerche, A. Lescinskis, J. Lewis, W. Leysen, L. Li, Y. Li, J. Likonen, Ch. Linsmeier, B. Lipschultz, X. Litaudon, E. Litherland-Smith, F. Liu, T. Loarer, A. Loarte, R. Lobel, B. Lomanowski, P.J. Lomas, J.M. López, R. Lorenzini, S. Loreti, U. Losada, V.P. Loschiavo, M. Loughlin, Z. Louka, J. Lovell, T. Lowe, C. Lowry, S. Lubbad, T. Luce, R. Lucock, A. Lukin, C. Luna, E.de la Luna, M. Lungaroni, C.P. Lungu, T. Lunt, V. Lutsenko, B. Lyons, A. Lyssoivan, M. Machielsen, E. Macusova, R. Mäenpää, C.F. Maggi, R. Maggiora, M. Magness, S. Mahesan, H. Maier, R. Maingi, K. Malinowski, P. Manas, P. Mantica, M.J. Mantsinen, J. Manyer, A. Manzanares, Ph. Maquet, G. Marceca, N. Marcenko, C. Marchetto, O. Marchuk, A. Mariani, G. Mariano, M. Marin, M. Marinelli, T. Markovič, D. Marocco, L. Marot, S. Marsden, J. Marsh, R. Marshall, L. Martellucci, A. Martin, A.J. Martin, R. Martone, S. Maruyama, M. Maslov, S. Masuzaki, S. Matejcik, M. Mattei, G.F. Matthews, D. Matveev, E. Matveeva, A. Mauriya, F. Maviglia, M. Mayer, M.-L. Mayoral, S. Mazzi, C. Mazzotta, R. McAdams, P.J. McCarthy, K.G. McClements, J. McClenaghan, P. McCullen, D.C. McDonald, D. McGuckin, D. McHugh, G. McIntyre, R. McKean, J. McKehon, B. McMillan, L. McNamee, A. McShee, A. Meakins, S. Medley, C.J. Meekes, K. Meghani, A.G. Meigs, G. Meisl, S. Meitner, S. Menmuir, K. Mergia, S. Merriman, Ph. Mertens, S. Meshchaninov, A. Messiaen, R. Michling, P. Middleton, D. Middleton-Gear, J. Mietelski, D. Milanesio, E. Milani, F. Militello, A.Militello Asp, J. Milnes, A. Milocco, G. Miloshevsky, C. Minghao, S. Minucci, I. Miron, M. Miyamoto, J. Mlynář, V. Moiseenko, P. Monaghan, I. Monakhov, T. Moody, S. Moon, R. Mooney, S. Moradi, J. Morales, R.B. Morales, S. Mordijck, L. Moreira, L. Morgan, F. Moro, J. Morris, K.-M. Morrison, L. Msero, D. Moulton, T. Mrowetz, T. Mundy, M. Muraglia, A. Murari, A. Muraro, N. Muthusonai, B. N’Konga, Yong-Su Na, F. Nabais, M. Naden, J. Naish, R. Naish, F. Napoli, E. Nardon, V. Naulin, M.F.F. Nave, I. Nedzelskiy, G. Nemtsev, V. Nesenevich, I. Nestoras, R. Neu, V.S. Neverov, S. Ng, M. Nicassio, A.H. Nielsen, D. Nina, D. Nishijima, C. Noble, C.R. Nobs, M. Nocente, D. Nodwell, K. Nordlund, H. Nordman, R. Normanton, J.M. Noterdaeme, S. Nowak, E. Nunn, H. Nyström, M. Oberparleiter, B. Obryk, J. O'Callaghan, T. Odupitan, H.J.C. Oliver, R. Olney, M. O’Mullane, J. Ongena, E. Organ, F. Orsitto, J. Orszagh, T. Osborne, R. Otin, T. Otsuka, A. Owen, Y. Oya, M. Oyaizu, R. Paccagnella, N. Pace, L.W. Packer, S. Paige, E. Pajuste, D. Palade, S.J.P. Pamela, N. Panadero, E. Panontin, A. Papadopoulos, G. Papp, P. Papp, V.V. Parail, C. Pardanaud, J. Parisi, F.Parra Diaz, A. Parsloe, M. Parsons, N. Parsons, M. Passeri, A. Patel, A. Pau, G. Pautasso, R. Pavlichenko, A. Pavone, E. Pawelec, C.Paz Soldan, A. Peacock, M. Pearce, E. Peluso, C. Penot, K. Pepperell, R. Pereira, T. Pereira, E.Perelli Cippo, P. Pereslavtsev, C. Perez von Thun, V. Pericoli, D. Perry, M. Peterka, P. Petersson, G. Petravich, N. Petrella, M. Peyman, M. Pillon, S. Pinches, G. Pintsuk, W. Pires de Sá, A. Pires dos Reis, C. Piron, L. Pionr, A. Pironti, R. Pitts, K.L. van de Plassche, N. Platt, V. Plyusnin, M. Podesta, G. Pokol, F.M. Poli, O.G. Pompilian, S. Popovichev, M. Poradziński, M.T. Porfiri, M. Porkolab, C. Porosnicu, M. Porton, G. Poulipoulis, I. Predebon, G. Prestopino, C. Price, D. Price, M. Price, D. Primetzhofer, P. Prior, G. Provatas, G. Pucella, P. Puglia, K. Purahoo, I. Pusztai, O. Putignano, T. Pütterich, A. Quercia, E. Rachlew, G. Radulescu, V. Radulovic, M. Rainford, P. Raj, G. Ralph, G. Ramogida, D. Rasmussen, J.J. Rasmussen, G. Rattá, S. Ratynskaia, M. Rebai, D. Réfy, R. Reichle, M. Reinke, D. Reiser, C. Reux, S. Reynolds, M.L. Richiusa, S. Richyal, D. Rigamonti, F.G. Rimini, J. Risner, M. Riva, J. Rivero-Rodriguez, C.M. Roach, R. Robins, S. Robinson, D. Robson, R. Rodionov, P. Rodrigues, M.Rodriguez Ramos, P. Rodriguez-Fernandez, F. Romanelli, M. Romanelli, S. Romanelli, J. Romazanov, R. Rossi, S. Rowe, D. Rowlands, M. Rubel, G. Rubinacci, G. Rubino, L. Ruchko, M. Ruiz, J.Ruiz Ruiz, C. Ruset, J. Rzadkiewicz, S. Saarelma, E. Safi, A. Sahlberg, M. Salewski, A. Salmi, R. Salmon, F. Salzedas, I. Sanders, D. Sandiford, B. Santos, A. Santucci, K. Särkimäki, R. Sarwar, I. Sarychev, O. Sauter, P. Sauwan, N. Scapin, F. Schluck, K. Schmid, S. Schmuck, M. Schneider, P.A. Schneider, D. Schwörer, G. Scott, M. Scott, D. Scraggs, S. Scully, M. Segato, Jaemin Seo, G. Sergienko, M. Sertoli, S.E. Sharapov, A. Shaw, H. Sheikh, U. Sheikh, A. Shepherd, A. Shevelev, P. Shigin, K. Shinohara, S. Shiraiwa, D. Shiraki, M. Short, G. Sias, S.A. Silburn, A. Silva, C. Silva, J. Silva, D. Silvagni, D. Simfukwe, J. Simpson, D. Sinclair, S.K. Sipilä, A.C.C. Sips, P. Sirén, A. Sirinelli, H. Sjöstrand, N. Skinner, J. Slater, N. Smith, P. Smith, J. Snell, G. Snoep, L. Snoj, P. Snyder, S. Soare, E.R. Solano, V. Solokha, A. Somers, C. Sommariva, K. Soni, E. Sorokovoy, M. Sos, J. Sousa, C. Sozzi, S. Spagnolo, T. Spelzini, F. Spineanu, D. Spong, D. Sprada, S. Sridhar, C. Srinivasan, G. Stables, G. Staebler, I. Stamatelatos, Z. Stancar, P. Staniec, G. Stankūnas, M. Stead, E. Stefanikova, A. Stephen, J. Stephens, P. Stevenson, M. Stojanov, P. Strand, H.R. Strauss, S. Strikwerda, P. Ström, C.I. Stuart, W. Studholme, M. Subramani, E. Suchkov, S. Sumida, H.J. Sun, T.E. Susts, J. Svensson, J. Svoboda, R. Sweeney, D. Sytnykov, T. Szabolics, G. Szepesi, B. Tabia, T. Tadić, B. Tál, T. Tala, A. Tallargio, P. Tamain, H. Tan, K. Tanaka, W. Tang, M. Tardocchi, D. Taylor, A.S. Teimane, G. Telesca, N. Teplova, A. Teplukhina, D. Terentyev, A. Terra, D. Terranova, N. Terranova, D. Testa, E. Tholerus, J. Thomas, E. Thoren, A. Thorman, W. Tierens, R.A. Tinguely, A. Tipton, H. Todd, M. Tokitani, P. Tolias, M. Tomeš, A. Tookey, Y. Torikai, U. von Toussaint, P. Tsavalas, D. Tskhakaya, I. Turner, M. Turner, M.M. Turner, M. Turnyanskiy, G. Tvalashvili, S. Tyrrell, M. Tyshchenko, A. Uccello, V. Udintsev, G. Urbanczyk, A. Vadgama, D. Valcarcel, M. Valisa, P.Vallejos Olivares, O. Vallhagen, M. Valovič, D. Van Eester, J. Varje, S. Vartanian, T. Vasilopoulou, G. Vayakis, M. Vecsei, J. Vega, S. Ventre, G. Verdoolaege, C. Verona, G.Verona Rinati, E. Veshchev, N. Vianello, E. Viezzer, L. Vignitchouk, R. Vila, R. Villari, F. Villone, P. Vincenzi, I. Vinyar, B. Viola, A.J. Virtanen, A. Vitins, Z. Vizvary, G. Vlad, M. Vlad, P. Vondráček, P.de Vries, B. Wakeling, N.R. Walkden, M. Walker, R. Walker, M. Walsh, E. Wang, N. Wang, S. Warder, R. Warren, J. Waterhouse, C. Watts, T. Wauters, A. Weckmann, H.Wedderburn Maxwell, M. Weiland, H. Weisen, M. Weiszflog, P. Welch, N. Wendler, A. West, M. Wheatley, S. Wheeler, A. Whitehead, D. Whittaker, A. Widdowson, S. Wiesen, J. Wilkinson, J.C. Williams, D. Willoughby, I. Wilson, J. Wilson, T. Wilson, M. Wischmeier, P. Wise, G. Withenshaw, A. Withycombe, D. Witts, A. Wojcik-Gargula, E. Wolfrum, R. Wood, C. Woodley, R. Woodley, B. Woods, J. Wright, J.C. Wright, T. Xu, D. Yadikin, M. Yajima, Y. Yakovenko, Y. Yang, W. Yanling, V. Yanovskiy, I. Young, R. Young, R.J. Zabolockis, J. Zacks, R. Zagorski, F.S. Zaitsev, L. Zakharov, A. Zarins, D. Zarzoso Fernandez, K.-D. Zastrow, Y. Zayachuk, M. Zerbini, W. Zhang, Y. Zhou, M. Zlobinski, A. Zocco, A. Zohar, V. Zoita, S. Zoletnik, V.K. Zotta, I. Zoulias, W. Zwingmann, I. Zychor, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, Uppsala University, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max-Planck-Institut für Plasmaphysik, KTH Royal Institute of Technology, Aalto-yliopisto, Aalto University, JET Contributor, Mailloux, Joelle, Chiariello, Andrea, Martone, Raffaele, Formisano, Alessandro, Mattei, Massimiliano, Faculdade de Engenharia, Universitat Politècnica de Catalunya. Departament de Mecànica de Fluids, Barcelona Supercomputing Center, Albanese, Raffaele, Ambrosino, Giuseppe, Ambrosino, Roberto, Coccorese, Vincenzo, De Tommasi, Gianmaria, Fresa, Raffaele, Pironti, Alfredo, Quercia, Antonio, Rubinacci, Guglielmo, Et, Al, Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, Begolli, A, Beidler, M, Bekris, N, Beldishevski, M, Belli, E, Belli, F, Belonohy, E, Ben Yaala, M, Benayas, J, Bentley, J, Bergsaker, H, Bernardo, J, Bernert, M, Berry, M, Bertalot, L, Betar, H, Beurskens, M, Bickerton, S, Bieg, B, Bielecki, J, Bierwage, A, Biewer, T, Bilato, R, Bilkova, P, Birkenmeier, G, Bishop, H, Bizarro, J, Blackburn, J, Blanchard, P, Blatchford, P, Bobkov, V, Boboc, A, Bohm, P, Bohm, T, Bolshakova, I, Bolzonella, T, Bonanomi, N, Bonfiglio, D, Bonnin, X, Bonofiglo, P, Boocock, S, Booth, A, Booth, J, Borba, D, Borodin, D, Borodkina, I, Boulbe, C, Bourdelle, C, Bowden, M, Boyd, K, Mihalic, I, Bradnam, S, Braic, V, Brandt, L, Bravanec, R, Breizman, B, Brett, A, Brezinsek, S, Brix, M, Bromley, K, Brown, B, Brunetti, D, Buckingham, R, Buckley, M, Budny, R, Buermans, J, Bufferand, H, Buratti, P, Burgess, A, Buscarino, A, Busse, A, Butcher, D, de la Cal, E, Calabro, G, Calacci, L, Calado, R, Camenen, Y, Canal, G, Cannas, B, Cappelli, M, Carcangiu, S, Card, P, Cardinali, A, Carman, P, Carnevale, D, Carr, M, Carralero, D, Carraro, L, Carvalho, I, Carvalho, P, Casiraghi, I, Casson, F, Castaldo, C, Catalan, J, Catarino, N, Causa, F, Cavedon, M, Cecconello, M, Challis, C, Chamberlain, B, Chang, C, Chankin, A, Chapman, B, Chernyshova, M, Chiariello, A, Chmielewski, P, Chomiczewska, A, Chone, L, Ciraolo, G, Ciric, D, Clark, M, Clarkson, R, Clements, C, Cleverly, M, Coad, J, Coates, P, Cobalt, A, Coccorese, V, Coelho, R, Coenen, J, Coffey, I, Colangeli, A, Colas, L, Collins, C, Collins, J, Collins, S, Conka, D, Conroy, S, Conway, B, Conway, N, Coombs, D, Cooper, P, Cooper, S, Corradino, C, Corrigan, G, Coster, D, Cox, P, Craciunescu, T, Cramp, S, Crapper, C, Craven, D, Craven, R, Esposito, M, Croci, G, Croft, D, Croitoru, A, Crombe, K, Cronin, T, Cruz, N, Crystal, C, Cseh, G, Cufar, A, Cullen, A, Curuia, M, Czarski, T, Dabirikhah, H, Dal Molin, A, Dale, E, Dalgliesh, P, Dalley, S, Dankowski, J, David, P, Davies, A, Davies, S, Davis, G, Dawson, K, Dawson, S, Day, I, De Bock, M, De Temmerman, G, De Tommasi, G, Deakin, K, Deane, J, Dejarnac, R, Del Sarto, D, Delabie, E, Del-Castillo-Negrete, D, Dempsey, A, Dendy, R, Devynck, P, Di Siena, A, Di Troia, C, Dickson, T, Dinca, P, Dittmar, T, Dobrashian, J, Doerner, R, Donne, A, Dorling, S, Dormido-Canto, S, Douai, D, Dowson, S, Doyle, R, Dreval, M, Drewelow, P, Drews, P, Drummond, G, Duckworth, P, Dudding, H, Dumont, R, Dumortier, P, Dunai, D, Dunatov, T, Dunne, M, Durodie, F, Dux, R, Dvornova, A, Eastham, R, Edwards, J, Eich, T, Eichorn, A, Eidietis, N, Eksaeva, A, El Haroun, H, Ellwood, G, Elsmore, C, Embreus, O, Emery, S, Ericsson, G, Eriksson, B, Eriksson, F, Eriksson, J, Eriksson, L, Ertmer, S, Esquembri, S, Esquisabel, A, Estrada, T, Evans, G, Evans, S, Fable, E, Fagan, D, Faitsch, M, Falessi, M, Fanni, A, Farahani, A, Farquhar, I, Fasoli, A, Faugeras, B, Fazinic, S, Felici, F, Felton, R, Fernandes, A, Fernandes, H, Ferrand, J, Ferreira, D, Ferreira, J, Ferro, G, Fessey, J, Ficker, O, Field, A, Figueiredo, A, Figueiredo, J, Fil, A, Fil, N, Finburg, P, Fiorucci, D, Fischer, U, Fishpool, G, Fittill, L, Fitzgerald, M, Flammini, D, Flanagan, J, Flinders, K, Foley, S, Fonnesu, N, Fontana, M, Fontdecaba, J, Forbes, S, Formisano, A, Fornal, T, Fortuna, L, Fortuna-Zalesna, E, Fortune, M, Fowler, C, Fransson, E, Frassinetti, L, Freisinger, M, Fresa, R, Fridstrom, R, Frigione, D, Fulop, T, Furseman, M, Fusco, V, Futatani, S, Gadariya, D, Gal, K, Galassi, D, Galazka, K, Galeani, S, Gallart, D, Galvao, R, Gao, Y, Garcia, J, Garcia-Munoz, M, Gardener, M, Garzotti, L, Gaspar, J, Gatto, R, Gaudio, P, Gear, D, Gebhart, T, Gee, S, Gelfusa, M, George, R, Gerasimov, S, Gervasini, G, Gethins, M, Ghani, Z, Gherendi, M, Ghezzi, F, Giacalone, J, Giacomelli, L, Giacometti, G, Gibson, C, Gibson, K, Gil, L, Gillgren, A, Gin, D, Giovannozzi, E, Giroud, C, Glen, R, Gloggler, S, Goff, J, Gohil, P, Goloborodko, V, Gomes, R, Goncalves, B, Goniche, M, Goodyear, A, Gore, S, Gorini, G, Gorler, T, Gotts, N, Goulding, R, Gow, E, Graham, B, Graves, J, Greuner, H, Grierson, B, Griffiths, J, Griph, S, Grist, D, Gromelski, W, Groth, M, Grove, R, Gruca, M, Guard, D, Gupta, N, Gurl, C, Gusarov, A, Hackett, L, Hacquin, S, Hager, R, Hagg, L, Hakola, A, Halitovs, M, Hall, S, Hallworth-Cook, S, Ham, C, Hamaguchi, D, Hamed, M, Hamlyn-Harris, C, Hammond, K, Harford, E, Harrison, J, Harting, D, Hatano, Y, Hatch, D, Haupt, T, Hawes, J, Hawkes, N, Hawkins, J, Hayashi, T, Hazael, S, Hazel, S, Heesterman, P, Heidbrink, B, Helou, W, Hemming, O, Henderson, S, Henriques, R, Hepple, D, Herfindal, J, Hermon, G, Hill, J, Hillesheim, J, Hizanidis, K, Hjalmarsson, A, Ho, A, Hobirk, J, Hoenen, O, Hogben, C, Hollingsworth, A, Hollis, S, Hollmann, E, Holzl, M, Homan, B, Hook, M, Hopley, D, Horsley, D, Horsten, N, Horton, A, Horton, L, Horvath, L, Hotchin, S, Howell, R, Hu, Z, Huber, A, Huber, V, Huddleston, T, Huijsmans, G, Huynh, P, Hynes, A, Iliasova, M, Imrie, D, Imrisek, M, Ingleby, J, Innocente, P, Bjork, K, Isernia, N, Ivanova-Stanik, I, Ivings, E, Jablonski, S, Jachmich, S, Jackson, T, Jacquet, P, Jarleblad, H, Jaulmes, F, Rodriguez, J, Jepu, I, Joffrin, E, Johnson, R, Johnson, T, Johnston, J, Jones, C, Jones, G, Jones, L, Jones, N, Jones, T, Joyce, A, Juarez, R, Juvonen, M, Kaltiaisenaho, T, Kaniewski, J, Kantor, A, Kappatou, A, Karhunen, J, Karkinsky, D, Kashchuk, Y, Kaufman, M, Kaveney, G, Kazakov, Y, Kazantzidis, V, Keeling, D, Kelly, R, Kempenaars, M, Kennedy, C, Kennedy, D, Kent, J, Khan, K, Khilkevich, E, Kiefer, C, Kilpelainen, J, Kim, C, Kim, H, Kim, S, King, D, King, R, Kinna, D, Kiptily, V, Kirjasuo, A, Kirov, K, Kirschner, A, Kiviniemi, T, Kizane, G, Klas, M, Klepper, C, Klix, A, Kneale, G, Knight, M, Knight, P, Knights, R, Knipe, S, Knolker, M, Knott, S, Kocan, M, Kochl, F, Kodeli, I, Kolesnichenko, Y, Kominis, Y, Kong, M, Korovin, V, Kos, B, Kos, D, Koslowski, H, Kotschenreuther, M, Koubiti, M, Koziol, K, Krasilnikov, A, Krasilnikov, V, Kresina, M, Krieger, K, Krishnan, N, Krivska, A, Kruezi, U, Kukushkin, A, Kumpulainen, H, Kurki-Suonio, T, Kurotaki, H, Kwak, S, Kwon, O, Laguardia, L, Lagzdina, E, Lahtinen, A, Laing, A, Lam, N, Lambertz, H, Lane, B, Lane, C, Neto, E, Lawson, K, Lazaros, A, Lazzaro, E, Learoyd, G, Lee, C, Lee, S, Leerink, S, Leeson, T, Lefebvre, X, Leggate, H, Lehmann, J, Lehnen, M, Leichtle, D, Leipold, F, Lengar, I, Lennholm, M, Gutierrez, E, Lepiavko, B, Leppanen, J, Lerche, E, Lescinskis, A, Lewis, J, Leysen, W, Li, L, Li, Y, Likonen, J, Linsmeier, C, Lipschultz, B, Litaudon, X, Litherland-Smith, E, Liu, F, Loarer, T, Loarte, A, Lobel, R, Lomanowski, B, Lomas, P, Lopez, J, Lorenzini, R, Loreti, S, Losada, U, Loschiavo, V, Loughlin, M, Louka, Z, Lovell, J, Lowe, T, Lowry, C, Lubbad, S, Luce, T, Lucock, R, Lukin, A, Luna, C, de la Luna, E, Lungaroni, M, Lungu, C, Lunt, T, Lutsenko, V, Lyons, B, Lyssoivan, A, Machielsen, M, Macusova, E, Maenpaa, R, Maggi, C, Maggiora, R, Magness, M, Mahesan, S, Maier, H, Maingi, R, Malinowski, K, Manas, P, Mantica, P, Mantsinen, M, Manyer, J, Manzanares, A, Maquet, P, Marceca, G, Marcenko, N, Marchetto, C, Marchuk, O, Mariani, A, Mariano, G, Marin, M, Marinelli, M, Markovic, T, Marocco, D, Marot, L, Marsden, S, Marsh, J, Marshall, R, Martellucci, L, Martin, A, Martone, R, Maruyama, S, Maslov, M, Masuzaki, S, Matejcik, S, Mattei, M, Matthews, G, Matveev, D, Matveeva, E, Mauriya, A, Maviglia, F, Mayer, M, Mayoral, M, Mazzi, S, Mazzotta, C, Mcadams, R, Mccarthy, P, Mcclements, K, Mcclenaghan, J, Mccullen, P, Mcdonald, D, Mcguckin, D, Mchugh, D, Mcintyre, G, Mckean, R, Mckehon, J, Mcmillan, B, Mcnamee, L, Mcshee, A, Meakins, A, Medley, S, Meekes, C, Meghani, K, Meigs, A, Meisl, G, Meitner, S, Menmuir, S, Mergia, K, Merriman, S, Mertens, P, Meshchaninov, S, Messiaen, A, Michling, R, Middleton, P, Middleton-Gear, D, Mietelski, J, Milanesio, D, Milani, E, Militello, F, Asp, A, Milnes, J, Milocco, A, Miloshevsky, G, Minghao, C, Minucci, S, Miron, I, Miyamoto, M, Mlynar, J, Moiseenko, V, Monaghan, P, Monakhov, I, Moody, T, Moon, S, Mooney, R, Moradi, S, Morales, J, Morales, R, Mordijck, S, Moreira, L, Morgan, L, Moro, F, Morris, J, Morrison, K, Msero, L, Moulton, D, Mrowetz, T, Mundy, T, Muraglia, M, Murari, A, Muraro, A, Muthusonai, N, Na, Y, Nabais, F, Naden, M, Naish, J, Naish, R, Napoli, F, Nardon, E, Naulin, V, Nave, M, Nedzelskiy, I, Nemtsev, G, Nesenevich, V, Nestoras, I, Neu, R, Neverov, V, Ng, S, Nicassio, M, Nielsen, A, Nina, D, Nishijima, D, Noble, C, Nobs, C, Nocente, M, Nodwell, D, Nordlund, K, Nordman, H, Normanton, R, Noterdaeme, J, Nowak, S, Nunn, E, Nystrom, H, Oberparleiter, M, Obryk, B, O'Callaghan, J, Odupitan, T, Oliver, H, Olney, R, O'Mullane, M, Ongena, J, Organ, E, Orsitto, F, Orszagh, J, Osborne, T, Otin, R, Otsuka, T, Owen, A, Oya, Y, Oyaizu, M, Paccagnella, R, Pace, N, Packer, L, Paige, S, Pajuste, E, Palade, D, Pamela, S, Panadero, N, Panontin, E, Papadopoulos, A, Papp, G, Papp, P, Parail, V, Pardanaud, C, Parisi, J, Diaz, F, Parsloe, A, Parsons, M, Parsons, N, Passeri, M, Patel, A, Pau, A, Pautasso, G, Pavlichenko, R, Pavone, A, Pawelec, E, Soldan, C, Peacock, A, Pearce, M, Peluso, E, Penot, C, Pepperell, K, Pereira, R, Pereira, T, Cippo, E, Pereslavtsev, P, von Thun, C, Pericoli, V, Perry, D, Peterka, M, Petersson, P, Petravich, G, Petrella, N, Peyman, M, Pillon, M, Pinches, S, Pintsuk, G, de Sa, W, dos Reis, A, Piron, C, Pionr, L, Pironti, A, Pitts, R, van de Plassche, K, Platt, N, Plyusnin, V, Podesta, M, Pokol, G, Poli, F, Pompilian, O, Popovichev, S, Poradzinski, M, Porfiri, M, Porkolab, M, Porosnicu, C, Porton, M, Poulipoulis, G, Predebon, I, Prestopino, G, Price, C, Price, D, Price, M, Primetzhofer, D, Prior, P, Provatas, G, Pucella, G, Puglia, P, Purahoo, K, Pusztai, I, Putignano, O, Putterich, T, Quercia, A, Rachlew, E, Radulescu, G, Radulovic, V, Rainford, M, Raj, P, Ralph, G, Ramogida, G, Rasmussen, D, Rasmussen, J, Ratta, G, Ratynskaia, S, Rebai, M, Refy, D, Reichle, R, Reinke, M, Reiser, D, Reux, C, Reynolds, S, Richiusa, M, Richyal, S, Rigamonti, D, Rimini, F, Risner, J, Riva, M, Rivero-Rodriguez, J, Roach, C, Robins, R, Robinson, S, Robson, D, Rodionov, R, Rodrigues, P, Ramos, M, Rodriguez-Fernandez, P, Romanelli, F, Romanelli, M, Romanelli, S, Romazanov, J, Rossi, R, Rowe, S, Rowlands, D, Rubel, M, Rubinacci, G, Rubino, G, Ruchko, L, Ruiz, M, Ruiz, J, Ruset, C, Rzadkiewicz, J, Saarelma, S, Safi, E, Sahlberg, A, Salewski, M, Salmi, A, Salmon, R, Salzedas, F, Sanders, I, Sandiford, D, Santos, B, Santucci, A, Sarkimaki, K, Sarwar, R, Sarychev, I, Sauter, O, Sauwan, P, Scapin, N, Schluck, F, Schmid, K, Schmuck, S, Schneider, M, Schneider, P, Schworer, D, Scott, G, Scott, M, Scraggs, D, Scully, S, Segato, M, Seo, J, Sergienko, G, Sertoli, M, Sharapov, S, Shaw, A, Sheikh, H, 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M, Taylor, D, Teimane, A, Telesca, G, Teplova, N, Teplukhina, A, Terentyev, D, Terra, A, Terranova, D, Terranova, N, Testa, D, Tholerus, E, Thomas, J, Thoren, E, Thorman, A, Tierens, W, Tinguely, R, Tipton, A, Todd, H, Tokitani, M, Tolias, P, Tomes, M, Tookey, A, Torikai, Y, von Toussaint, U, Tsavalas, P, Tskhakaya, D, Turner, I, Turner, M, Turnyanskiy, M, Tvalashvili, G, Tyrrell, S, Tyshchenko, M, Uccello, A, Udintsev, V, Urbanczyk, G, Vadgama, A, Valcarcel, D, Valisa, M, Olivares, P, Vallhagen, O, Van Eester, D, Varje, J, Vartanian, S, Vasilopoulou, T, Vayakis, G, Vecsei, M, Vega, J, Ventre, S, Verdoolaege, G, Verona, C, Rinati, G, Veshchev, E, Vianello, N, Viezzer, E, Vignitchouk, L, Vila, R, Villari, R, Villone, F, Vincenzi, P, Vinyar, I, Viola, B, Virtanen, A, Vitins, A, Vizvary, Z, Vlad, G, Vlad, M, Vondracek, P, de Vries, P, Wakeling, B, Walkden, N, Walker, M, Walker, R, Walsh, M, Wang, E, Wang, N, Warder, S, Warren, R, Waterhouse, J, Watts, C, Wauters, T, Weckmann, A, Maxwell, H, Weiland, M, Weisen, H, Weiszflog, M, Welch, P, Wendler, N, West, A, Wheatley, M, Wheeler, S, Whitehead, A, Whittaker, D, Widdowson, A, Wiesen, S, Wilkinson, J, Williams, J, Willoughby, D, Wilson, I, Wilson, J, Wilson, T, Wischmeier, M, Wise, P, Withenshaw, G, Withycombe, A, Witts, D, Wojcik-Gargula, A, Wolfrum, E, Wood, R, Woodley, C, Woodley, R, Woods, B, Wright, J, Xu, T, Yadikin, D, Yajima, M, Yakovenko, Y, Yang, Y, Yanling, W, Yanovskiy, V, Young, I, Young, R, Zabolockis, R, Zacks, J, Zagorski, R, Zaitsev, F, Zakharov, L, Zarins, A, Fernandez, D, Zastrow, K, Zayachuk, Y, Zerbini, M, Zhang, W, Zhou, Y, Zlobinski, M, Zocco, A, Zohar, A, Zoita, V, Zoletnik, S, Zotta, V, Zoulias, I, Zwingmann, W, and Zychor, I
- Subjects
Technology ,TOKAMAKS ,PLASMAS ,overview ,CONFINEMENT ,plasma facing components (PFC) ,ILW ,tritium operations ,d-t preparation ,deuterium ,D–T preparation ,nuclear technology ,JET with ITER-like wall ,isotope ,Física::Física de fluids::Física de plasmes [Àrees temàtiques de la UPC] ,Settore FIS/01 ,GAS HANDLING-SYSTEM ,JET ,Overview ,ITER-like wall (ILW) ,D-T preparation ,energetic particles ,scenario development ,Shattered Pellet Injection (SPI) ,plasma-wall interactions (PWI) ,tritium ,Physics ,Settore ING-IND/18 - Fisica dei Reattori Nucleari ,shutdown dose-rate ,gas handling-system ,Condensed Matter Physics ,simulation ,Fusion, Plasma and Space Physics ,ilw ,confinement ,Physical Sciences ,SIMULATION ,JET with ITER-like wallisotope ,ddc:620 ,performance ,plasma facing components (pfc) ,Nuclear and High Energy Physics ,DEUTERIUM ,jet with iter-like wall ,Fusion, plasma och rymdfysik ,Physics, Fluids & Plasmas ,BERYLLIUM ,divertor ,TRITIUM ,Science & Technology ,Reactors de fusió ,tritium operation ,Nuclear energy ,PERFORMANCE ,beryllium ,SHUTDOWN DOSE-RATE ,Fusion reactors ,Physics and Astronomy ,JET programme ,Energia nuclear ,DIVERTOR ,ddc:600 - Abstract
The JET 2019–2020 scientific and technological programme exploited the results of years of concerted scientific and engineering work, including the ITER-like wall (ILW: Be wall and W divertor) installed in 2010, improved diagnostic capabilities now fully available, a major neutral beam injection upgrade providing record power in 2019–2020, and tested the technical and procedural preparation for safe operation with tritium. Research along three complementary axes yielded a wealth of new results. Firstly, the JET plasma programme delivered scenarios suitable for high fusion power and alpha particle (a) physics in the coming D–T campaign (DTE2), with record sustained neutron rates, as well as plasmas for clarifying the impact of isotope mass on plasma core, edge and plasma-wall interactions, and for ITER pre-fusion power operation. The efficacy of the newly installed shattered pellet injector for mitigating disruption forces and runaway electrons was demonstrated. Secondly, research on the consequences of long-term exposure to JET-ILW plasma was completed, with emphasis on wall damage and fuel retention, and with analyses of wall materials and dust particles that will help validate assumptions and codes for design and operation of ITER and DEMO. Thirdly, the nuclear technology programme aiming to deliver maximum technological return from operations in D, T and D–T benefited from the highest D–D neutron yield in years, securing results for validating radiation transport and activation codes, and nuclear data for ITER. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under Grant Agreement No. 633053. Peer Reviewed Article signat per 1223 autors/autores: J. Mailloux1, N. Abid1, K. Abraham1, P. Abreu2, O. Adabonyan1, P. Adrich3, V. Afanasev4, M. Afzal1, T. Ahlgren5, L. Aho-Mantila6, N. Aiba7, M. Airila6, M. Akhtar1, R. Albanese8, M. Alderson-Martin1, D. Alegre9, S. Aleiferis10, A. Aleksa1, A.G. Alekseev11, E. Alessi12, P. Aleynikov13, J. Algualcil14, M. Ali1, M. Allinson1, B. Alper1, E. Alves2, G. Ambrosino8, R. Ambrosino8, V. Amosov15, E.Andersson Sunden16, P. Andrew13, B.M. Angelini17, C. Angioni18, I. Antoniou1, L.C. Appel1, C. Appelbee1, S. Aria1, M. Ariola8, G. Artaserse17, W. Arter1, V. Artigues18, N. Asakura7, A. Ash1, N. Ashikawa19, V. Aslanyan20, M. Astrain21, O. Asztalos22, D. Auld1, F. Auriemma23, Y. Austin1, L. Avotina24, E. Aymerich25, A. Baciero9, F. Bairaktaris26, J. Balbin27, L. Balbinot23, I. Balboa1, M. Balden18, C. Balshaw1, N. Balshaw1, V.K. Bandaru18, J. Banks1, Yu.F. Baranov1, C. Barcellona28, A. Barnard1, M. Barnard1, R. Barnsley13, A. Barth1, M. Baruzzo17, S. Barwell1, M. Bassan13, A. Batista2, P. Batistoni17, L. Baumane24, B. Bauvir13, L. Baylor29, P.S. Beaumont1, D. Beckett1, A. Begolli1, M. Beidler29, N. Bekris30,31, M. Beldishevski1, E. Belli32, F. Belli17, É. Belonohy1, M. Ben Yaala33, J. Benayas1, J. Bentley1, H. Bergsåker34, J. Bernardo2, M. Bernert18, M. Berry1, L. Bertalot13, H. Betar35, M. Beurskens36, S. Bickerton1, B. Bieg37, J. Bielecki38, A. Bierwage7, T. Biewer29, R. Bilato18, P. Bílková39, G. Birkenmeier18, H. Bishop1, J.P.S. Bizarro2, J. Blackburn1, P. Blanchard40, P. Blatchford1, V. Bobkov18, A. Boboc1, P. Bohm39, T. Bohm41, I. Bolshakova42, T. Bolzonella23, N. Bonanomi18, D. Bonfiglio23, X. Bonnin13, P. Bonofiglo43, S. Boocock1, A. Booth1, J. Booth1, D. Borba2,30, D. Borodin44, I. Borodkina39,44, C. Boulbe45, C. Bourdelle27, M. Bowden1, K. Boyd1, I.Bozicevic Mihalic46, S.C. Bradnam1, V. Braic47, L. Brandt48, R. Bravanec49, B. Breizman50, A. Brett1, S. Brezinsek44, M. Brix1, K. Bromley1, B. Brown1, D. Brunetti1,12, R. Buckingham1, M. Buckley1, R. Budny, J. Buermans51, H. Bufferand27, P. Buratti17, A. Burgess1, A. Buscarino28, A. Busse1, D. Butcher1, E.de la Cal9, G. Calabrò52, L. Calacci53, R. Calado2, Y. Camenen54, G. Canal55, B. Cannas25, M. Cappelli17, S. Carcangiu25, P. Card1, A. Cardinali17, P. Carman1, D. Carnevale53, M. Carr1, D. Carralero9, L. Carraro23, I.S. Carvalho2, P. Carvalho2, I. Casiraghi56, F.J. Casson1, C. Castaldo17, J.P. Catalan14, N. Catarino2, F. Causa12, M. Cavedon18, M. Cecconello16, C.D. Challis1, B. Chamberlain1, C.S. Chang43, A. Chankin18, B. Chapman1,57, M. Chernyshova58, A. Chiariello8, P. Chmielewski58, A. Chomiczewska58, L. Chone59, G. Ciraolo27, D. Ciric1, J. Citrin60, Ł. Ciupinski61, M. Clark1, R. Clarkson1, C. Clements1, M. Cleverly1, J.P. Coad1, P. Coates1, A. Cobalt1, V. Coccorese8, R. Coelho2, J.W. Coenen44, I.H. Coffey62, A. Colangeli17, L. Colas27, C. Collins29, J. Collins1, S. Collins1, D. Conka24, S. Conroy16, B. Conway1, N.J. Conway1, D. Coombs1, P. Cooper1, S. Cooper1, C. Corradino28, G. Corrigan1, D. Coster18, P. Cox1, T. Craciunescu63, S. Cramp1, C. Crapper1, D. Craven1, R. Craven1, M.Crialesi Esposito48, G. Croci56, D. Croft1, A. Croitoru63, K. Crombe51,64, T. Cronin1, N. Cruz2, C. Crystal32, G. Cseh22, A. Cufar65, A. Cullen1, M. Curuia66, T. Czarski58, H. Dabirikhah1, A.Dal Molin56, E. Dale1, P. Dalgliesh1, S. Dalley1, J. Dankowski38, P. David18, A. Davies1, S. Davies1, G. Davis1, K. Dawson1, S. Dawson1, I.E. Day1, M. De Bock13, G. De Temmerman13, G. De Tommasi8, K. Deakin1, J. Deane1, R. Dejarnac39, D. Del Sarto35, E. Delabie29, D. Del-Castillo-Negrete29, A. Dempsey67, R.O. Dendy1,57, P. Devynck27, A. Di Siena18, C. Di Troia17, T. Dickson1, P. Dinca63, T. Dittmar44, J. Dobrashian1, R.P. Doerner68, A.J.H. Donne´69, S. Dorling1, S. Dormido-Canto70, D. Douai27, S. Dowson1, R. Doyle67, M. Dreval71, P. Drewelow36, P. Drews44, G. Drummond1, Ph. Duckworth13, H. Dudding1,72, R. Dumont27, P. Dumortier51, D. Dunai22, T. Dunatov46, M. Dunne18, I. Duran39, F. Durodie51, R. Dux18, A. Dvornova27, R. Eastham1, J. Edwards1, Th. Eich18, A. Eichorn1, N. Eidietis32, A. Eksaeva44, H. El Haroun1, G. Ellwood13, C. Elsmore1, O. Embreus73, S. 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Hammond1, E. Harford1, J.R. Harrison1, D. Harting1, Y. Hatano84, D.R. Hatch50, T. Haupt1, J. Hawes1, N.C. Hawkes1, J. Hawkins1, T. Hayashi7, S. Hazael1, S. Hazel1, P. Heesterman1, B. Heidbrink85, W. Helou13, O. Hemming1, S.S. Henderson1, R.B. Henriques2, D. Hepple1, J. Herfindal29, G. Hermon1, J. Hill1, J.C. Hillesheim1, K. Hizanidis26, A. Hjalmarsson16, A. Ho60, J. Hobirk18, O. Hoenen13, C. Hogben1, A. Hollingsworth1, S. Hollis1, E. Hollmann68, M. Hölzl18, B. Homan45, M. Hook1, D. Hopley1, J. Horácek39, D. Horsley1, N. Horsten59, A. Horton1, L.D. Horton30,40, L. Horvath1,72, S. Hotchin1, R. Howell1, Z. Hu56, A. Huber44, V. Huber44, T. Huddleston1, G.T.A. Huijsmans13, P. Huynh27, A. Hynes1, M. Iliasova4, D. Imrie1, M. Imrísek39, J. Ingleby1, P. Innocente23, K. Insulander Björk73, N. Isernia8, I. Ivanova-Stanik58, E. Ivings1, S. Jablonski58, S. Jachmich13,30,51, T. Jackson1, P. Jacquet1, H. Järleblad86, F. Jaulmes39, J.Jenaro Rodriguez1, I. Jepu63, E. Joffrin27, R. Johnson1, T. 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Teplukhina43, D. Terentyev83, A. Terra44, D. Terranova23, N. Terranova17, D. Testa40, E. Tholerus1,34, J. Thomas1, E. Thoren113, A. Thorman1, W. Tierens18, R.A. Tinguely20, A. Tipton1, H. Todd1, M. Tokitani19, P. Tolias113, M. Tomes39, A. Tookey1, Y. Torikai118, U. von Toussaint18, P. Tsavalas10, D. Tskhakaya39,119, I. Turner1, M. Turner1, M.M. Turner67, M. Turnyanskiy1,69, G. Tvalashvili1, S. Tyrrell1, M. Tyshchenko82, A. Uccello12, V. Udintsev13, G. Urbanczyk27, A. Vadgama1, D. Valcarcel1, M. Valisa23, P.Vallejos Olivares34, O. Vallhagen73, M. Valovicˇ1, D. Van Eester51, J. Varje59, S. Vartanian27, T. Vasilopoulou10, G. Vayakis13, M. Vecsei22, J. Vega9, S. Ventre8, G. Verdoolaege64, C. Verona53, G.Verona Rinati53, E. Veshchev13, N. Vianello23, E. Viezzer79, L. Vignitchouk113, R. Vila9, R. Villari17, F. Villone8, P. Vincenzi23, I. Vinyar94, B. Viola17, A.J. Virtanen59, A. Vitins24, Z. Vizvary1, G. Vlad17, M. Vlad63, P. Vondrácek39, P.de Vries13, B. Wakeling1, N.R. Walkden1, M. 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Zychor3 // 1 United Kingdom Atomic Energy Authority, Culham Science Centre, Abingdon, Oxon, OX14 3DB, United Kingdom of Great Britain and Northern Ireland 2 Instituto de Plasmas e Fusao Nuclear, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal 3 National Centre for Nuclear Research (NCBJ), 05-400 Otwock-Swierk, Poland 4 Ioffe Physico-Technical Institute, 26 Politekhnicheskaya, St Petersburg 194021, Russia 5 University of Helsinki, PO Box 43, FI-00014 University of Helsinki, Finland 6 VTT Technical Research Centre of Finland, PO Box 1000, FIN-02044 VTT, Finland 7 National Institutes for Quantum and Radiological Science and Technology, Naka, Ibaraki 311-0193, Japan 8 Consorzio CREATE, Via Claudio 21, 80125 Napoli, Italy 9 Laboratorio Nacional de Fusión, CIEMAT, Madrid, Spain 10 NCSR ‘Demokritos’ 153 10, Agia Paraskevi Attikis, Greece 11 NRC Kurchatov Institute, 1 Kurchatov Square, Moscow 123182, Russia 12 Institute for Plasma Science and Technology, CNR, via R. Cozzi 53, 20125 Milano, Italy 13 ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 Saint Paul Lez Durance Cedex, France 14 Universidad Nacional de Educacion a Distancia, Dept Ingn Energet, Calle Juan del Rosal 12, E-28040 Madrid, Spain 15 Troitsk Insitute of Innovating and Thermonuclear Research (TRINITI), Troitsk 142190, Moscow Region, Russia 16 Department of Physics and Astronomy, Uppsala University, SE-75120 Uppsala, Sweden 17 Dip.to Fusione e Tecnologie per la Sicurezza Nucleare, ENEA C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma), Italy 18 Max-Planck-Institut für Plasmaphysik, D-85748 Garching, Germany 19 National Institute for Fusion Science, Oroshi, Toki, Gifu 509-5292, Japan 20 MIT Plasma Science and Fusion Center, Cambridge, MA 02139, United States of America 21 Universidad Politécnica de Madrid, Grupo I2A2, Madrid, Spain 22 Centre for Energy Research, POB 49, H-1525 Budapest, Hungary 23 Consorzio RFX, Corso Stati Uniti 4, 35127 Padova, Italy 24 University of Latvia, 19 Raina Blvd., Riga, LV 1586, Latvia 25 Department of Electrical and Electronic Engineering, University of Cagliari, Piazza d’Armi 09123 Cagliari, Italy 26 National Technical University of Athens, Iroon Politechniou 9, 157 73 Zografou, Athens, Greece 27 CEA, IRFM, F-13108 Saint Paul Lez Durance, France 28 Dipartimento di Ingegneria Elettrica Elettronica e Informatica, Università degli Studi di Catania, 95125 Catania, Italy 29 Oak Ridge National Laboratory, Oak Ridge, TN 37831, TN, United States of America 30 EUROfusion Programme Management Unit, Culham Science Centre, Culham, OX14 3DB, United Kingdom of Great Britain and Northern Ireland 31 Karlsruhe Institute of Technology, PO Box 3640, D-76021 Karlsruhe, Germany 32 General Atomics, PO Box 85608, San Diego, CA 92186-5608, United States of America 33 Department of Physics, University of Basel, Switzerland 34 Fusion Plasma Physics, EECS, KTH Royal Institute of Technology, SE-10044 Stockholm, Sweden 35 Institut Jean Lamour, UMR 7198, CNRS-Université de Lorraine, 54500 Vandoeuvre-lès-Nancy, France 36 Max-Planck-Institut für Plasmaphysik, Teilinsitut Greifswald, D-17491 Greifswald, Germany 37 Maritime University of Szczecin Faculty of Marine Engineering, Waly Chrobrego 1-2, 70-500 Szczecin, Poland 38 Institute of Nuclear Physics, Radzikowskiego 152, 31-342 Kraków, Poland 39 Institute of Plasma Physics of the CAS, Za Slovankou 1782/3, 182 00 Praha 8, Czech Republic 40 Ecole Polytechnique Fédérale de Lausanne (EPFL), Swiss Plasma Center (SPC), CH-1015 Lausanne, Switzerland 41 University of Wisconsin-Madison, Madison, WI 53706, United States of America 42 Magnetic Sensor Laboratory, Lviv Polytechnic National University, Lviv, Ukraine 43 Princeton Plasma Physics Laboratory, James Forrestal Campus, Princeton, NJ 08543, NJ, United States of America 44 Forschungszentrum Jülich GmbH, Institut für Energie- und Klimaforschung, Plasmaphysik, 52425 Jülich, Germany 45 Université Cote d’Azur, CNRS, Inria, LJAD, Parc Valrose, 06108 Nice Cedex 02, France 46 Ruder Boskovic Institute, Bijenicka 54, 10000 Zagreb, Croatia 47 The National Institute for Optoelectronics, Magurele-Bucharest, Romania 48 Mechanics, SCI, KTH SE-100 44 Stockholm, Sweden 49 Fourth State Research, 503 Lockhart Dr, Austin, TX, United States of America 50 University of Texas at Austin, Institute for Fusion Studies, Austin, TX 78712, United States of America 51 Laboratory for Plasma Physics LPP-ERM/KMS, B-1000 Brussels, Belgium 52 University of Tuscia, DEIM, Via del Paradiso 47, 01100 Viterbo, Italy 53 Università di Roma Tor Vergata, Via del Politecnico 1, Roma, Italy 54 Aix-Marseille University, CNRS, PIIM, UMR 7345, 13013 Marseille, France 55 Instituto de Física, Universidade de Sao Paulo, Rua do Mat˜ao Travessa R Nr.187, CEP 05508-090 Cidade Universitária, Sao Paulo, Brasil 56 University of Milano-Bicocca, Piazza della Scienza 3, 20126 Milano, Italy 57 Centre for Fusion, Space and Astrophysics, University of Warwick, Coventry, CV4 7AL, United Kingdom of Great Britain and Northern Ireland 58 Institute of Plasma Physics and Laser Microfusion, Hery 23, 01-497 Warsaw, Poland 59 Aalto University, PO Box 14100, FIN-00076 Aalto, Finland 60 FOM Institute DIFFER, Eindhoven, The Netherlands 61 Warsaw University of Technology, 02-507 Warsaw, Poland 62 Astrophysics Research Centre, School of Mathematics and Physics, Queen’s University, Belfast, BT7 1NN, United Kingdom of Great Britain and Northern Ireland 63 The National Institute for Laser, Plasma and Radiation Physics, Magurele-Bucharest, Romania 64 Department of Applied Physics, Ghent University, 9000 Ghent, Belgium 65 Slovenian Fusion Association (SFA), Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia 66 The National Institute for Cryogenics and Isotopic Technology, Ramnicu Valcea, Romania 67 Dublin City University (DCU), Dublin, Ireland 68 University of California at San Diego, La Jolla, CA 92093, United States of America 69 EUROfusion Programme Management Unit, Boltzmannstr. 2, 85748 Garching, Germany 70 UNED, Dpto. Informática y Automática, Madrid, Spain 71 National Science Center ‘Kharkov Institute of Physics and Technology’, Akademichna 1, Kharkiv 61108, Ukraine 72 York Plasma Institute, Department of Physics, University of York, York, YO10 5DD, United Kingdom of Great Britain and Northern Ireland 73 Department of Physics, Chalmers University of Technology, SE-41296 Gothenburg, Sweden 74 Department of Space, Earth and Environment, Chalmers University of Technology, SE-41296 Gothenburg, Sweden 75 European Commission, B-1049 Brussels, Belgium 76 University of Tennessee, Knoxville, TN 37996, TN, United States of America 77 Universitat Politècnica de Catalunya, Barcelona, Spain 78 Barcelona Supercomputing Center, Barcelona, Spain 79 Universidad de Sevilla, Sevilla, Spain 80 Aix-Marseille University, CNRS, IUSTI, UMR 7343, 13013 Marseille, France 81 Dipartimento di Ingegneria Astronautica, Elettrica ed Energetica, SAPIENZA Università di Roma, Via Eudossiana 18, 00184 Roma, Italy 82 Institute for Nuclear Research, Prospekt Nauky 47, Kyiv 03680, Ukraine 83 Studiecentrum voor Kernenergie—Centre d’Etude de l’Energie Nucléaire, Boeretang 200, 2400 Mol, Belgium 84 University of Toyama, Toyama, 930-8555, Japan 85 University of California, Irvine, Irvine, California 92697, United States of America 86 Department of Physics, Technical University of Denmark, Bldg 309, DK-2800 Kgs Lyngby, Denmark 87 Institution ‘Project Center ITER’, Moscow, 123182, Russia 88 Faculty of Mathematics, Department of Experimental Physics, Physics and Informatics Comenius University Mlynska dolina F2, 84248 Bratislava, Slovakia 89 University College Cork (UCC), Cork, Ireland 90 Institute of Physics, Opole University, Oleska 48, 45-052 Opole, Poland 91 Daegu University, Jillyang, Gyeongsan, Gyeongbuk 712-174, Republic of Korea 92 Department of Nuclear Engineering, Seoul National University, Seoul, Republic of Korea 93 Fusion for Energy Joint Undertaking, Josep Pl. 2, Torres Diagonal Litoral B3, 08019, Barcelona, Spain 94 PELIN LLC, 27a, Gzhatskaya Ulitsa, Saint Petersburg, 195220, Russia 95 Arizona State University, Tempe, AZ, United States of America 96 Politecnico di Torino, Corso Duca degli Abruzzi 24, I-10129 Torino, Italy 97 ICREA and Barcelona Supercomputing Center, Barcelona, Spain 98 Universidad Complutense de Madrid, Madrid, Spain 99 Istituto dei Sistemi Complessi—CNR and Dipartimento di Energia—Politecnico di Torino, C.so Duca degli Abruzzi 24, 10129 Torino, Italy 100 Eindhoven University of Technology, The Netherlands 101 Purdue University, 610 Purdue Mall, West Lafayette, IN 47907, United States of America 102 Department of Material Science, Shimane University, 1060 Nishikawatsu, Matsue, 690-8504, Japan 103 Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague, Brehová 78/7, 115 19 Praha 1, Czech Republic 104 College of William and Mary, Williamsburg, VA 23185, United States of America 105 University of California, 1111 Franklin St., Oakland, CA 94607, United States of America 106 University of Strathclyde, Glasgow, G4 0NG, United Kingdom of Great Britain and Northern Ireland 107 Kindai University, Higashi-Osaka, 577-8502, Japan 108 Shizuoka University, Shizuoka, 422-8529, Japan 109 Rudolf Peierls Centre for Theoretical Physics, University of Oxford, Oxford OX1 3PU, United Kingdom of Great Britain and Northern Ireland 110 Columbia University, New York, NY 10027, United States of America 111 Dipartimento di Fisica ‘G. Galilei’, Universita’ degli Studi di Padova, Padova, Italy 112 Space and Plasma Physics, EECS, KTH SE-100 44 Stockholm, Sweden 113 University of Ioannina, Panepistimioupoli Ioanninon, PO Box 1186, 45110 Ioannina, Greece 114 Universidade do Porto, Faculdade de Engenharia, 4200-465 Porto, Portugal 115 The University of Tokyo, Kashiwa, Chiba, 277-0882, Japan 116 Lithuanian Energy Institute, Breslaujos g. 3, LT-44403, Kaunas, Lithuania 117 HRS Fusion, West Orange, NJ, United States of America 118 Ibaraki University Graduate School of Science and Engineering, Mito, Ibaraki 310-8512, Japan 119 Technische Universität Wien, Fusion@ÖAW Österreichische Akademie der Wissenschaften (ÖAW), Austria
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53. Comparison of magnetic resonance-guided laser interstitial thermal therapy corpus callosum ablation to open microsurgical corpus callosotomy: A single-center retrospective cohort study.
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Phillips HW, Hect JL, Harford E, Pan E, and Abel TJ
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- Humans, Retrospective Studies, Treatment Outcome, Seizures, Magnetic Resonance Spectroscopy, Lasers, Corpus Callosum surgery, Laser Therapy
- Abstract
Objective: Corpus callosotomy (CC) is an important treatment for atonic seizures in patients with generalized or multifocal drug-resistant epilepsy (DRE). Traditionally, CC is performed via an open microsurgical approach, but more recently, MR-guided stereotactic laser interstitial thermal therapy (LITT) corpus callosum ablation (CCA) has been developed to leverage the safety and minimally invasive nature of LITT. Given the recent adoption of CCA at select centers, how CCA compares to CC is unknown. We aim to compare the clinical seizure outcomes of CCA and CC after extended follow-up., Methods: We performed a retrospective cohort study to compare the effectiveness and safety of CC to CCA from 1994 to 2022. The primary outcome was a 50% reduction in target seizure. Secondary outcome measures were postoperative length of stay, adverse events, and other effectiveness metrics. Comparative statistics were executed using Stata. Normality for continuous variables was assessed, and parametric statistics were utilized as needed. Frequency was compared with chi-squared or Fischer's exact tests, when applicable., Results: Data from 47 operations performed on 36 patients were included in this study, of which 13 (36%) patients underwent 17 CCA. Patients who received CCA had similar rates of meaningful reduction (>50%) of atonic seizures as their CC counterparts (55% vs 70% P = 0.15). Patients undergoing CCA had significantly shorter hospitalizations than those receiving CC (2.5 vs 6.0 days P < 0.001). There was no significant difference in rates of postoperative complications between the groups, although the magnitude of the complication rates was lower in the CCA cohort (12% vs 28%)., Significance: This early experience suggests CCA has similar outcomes to traditional CC, albeit with a shorter hospital stay. However, future studies are necessary to investigate the noninferiority between these two approaches. Large multicenter studies are necessary to investigate differences in adverse events and whether these findings generalize across other centers., (© 2023 The Authors. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
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- 2024
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54. Clinical outcomes of MR-guided laser interstitial thermal therapy corpus callosum ablation in drug-resistant epilepsy: a systematic review and meta-analysis.
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Hect JL, Harford E, Maroufi SF, Klem ML, Mansouri A, and Abel TJ
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- Adult, Child, Humans, Case-Control Studies, Corpus Callosum diagnostic imaging, Corpus Callosum surgery, Hemorrhage surgery, Lasers, Magnetic Resonance Imaging methods, Retrospective Studies, Treatment Outcome, Drug Resistant Epilepsy surgery, Epilepsy, Generalized surgery, Laser Therapy methods
- Abstract
Objective: The goal of this systematic review and meta-analysis was to provide an updated analysis of studies investigating outcomes, morbidity, and mortality associated with MR-guided laser interstitial thermal therapy (MRgLITT) corpus callosum ablation (CCA)., Methods: Study inclusion criteria for screening required that studies report on human subjects only, including patients aged 1-52 years diagnosed with drug-resistant epilepsy who underwent CCA. Sixteen articles published between 2016 and 2023 were included for the systematic review and analysis, including 4 case reports, 11 case series, and 1 case-control study. Altogether, 85 pediatric and adult patients undergoing CCA were included in the systematic review (46 patients younger and 39 patients older than 21 years). The main outcome of seizure freedom was measured using the decrease in the frequency of atonic seizures following surgery, percentage of atonic seizure freedom following surgery, and percentage of overall seizure freedom following surgery. These measurements were made using data from the last follow-up for patients with at least 6 months of follow-up post-CCA., Results: The extent of CCA differed across the pooled cohorts, including anterior two-thirds CCA (38.89%, n = 35) and posterior one-third CCA for completion of a prior partial CCA (22.22%, n = 20), complete CCA (27.78%, n = 25), or CCA of residual white matter in the case of subtotal initial ablation (5.56%, n = 5). Overall, 12.94% of the patients undergoing CCA experienced operational complications. The most common operative complications across 90 CCA operations were probe malpositioning (n = 6), hemorrhage (n = 5), off-target extension of splenium ablation to the thalamus (n = 1), infection (n = 1), and postoperative CSF leak (n = 1). Neurological deficits following CCA were reported as transient in 18.82% and permanent in 4.71% of patients across all studies. The most common neurological deficits were disconnection syndrome (n = 4) or transient hemiplegia (supplementary motor area-like syndrome; n = 4). The 6-month overall seizure freedom rate was 18.87% of 53 patients, and the atonic seizure freedom rate was 46.28% of 52 patients postoperatively. CCA resulted in an average decrease in atonic seizure rate from 8.30 to 1.65 atonic seizures per day (average decrease 80.12%)., Conclusions: CCA is associated with an acceptable complication profile, and most patients experience a meaningful reduction in target seizure semiologies. Accurate MRgLITT probe placement is likely important for maximizing CCA while avoiding collateral damage. Avoidable complications of CCA include off-target ablation (and associated deficits), hemorrhage, and future surgery for residual CCA to palliate continued seizures.
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- 2023
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55. Functional outcomes of pediatric hemispherotomy: Impairment, activity, and medical service utilization.
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Harford E, Houtrow A, Al-Ramadhani R, Sinha A, and Abel T
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- Child, Humans, Retrospective Studies, Treatment Outcome, Seizures surgery, Epilepsy surgery, Hemispherectomy methods
- Abstract
Objective: The purpose of this study was to describe the functional outcomes of hemispherotomy in a pediatric cohort, including impairments, activity limitations, utilization of therapies and medical specialist services, and subsequent surgical intervention., Methods: We conducted a retrospective review of patients who underwent hemispherotomy at UPMC Children's Hospital of Pittsburgh from 2001 to 2021. Data on impairments, activity limitations in mobility, self-care, and communication, and use of re/habilitative therapies and medical specialist services were collected pre-operatively and at 1, 5, 10, and 15 years postoperatively. Seizure outcomes were reported via Engel classification at the longest follow-up interval and subsequent surgical procedures were documented through the latest follow-up interval., Results: A total of 28 patients who underwent hemispherotomy were assessed prior to surgery, 26 at 1 year post-op, 13 at 5 years, 9 at 10 years, and 5 at 15 years. Seizure outcomes at the longest follow-up interval showed that 84.6% of patients were seizure-free. Assessment of impairments to body structure & function from baseline to 1-year post-op revealed increased impairment in 73% of patients, while most patients saw no change in impairment at 5 years (69%), 10 years (100%), and 15 years (100%) post-op compared to the previous time point. Muscle tone abnormalities (100%), hemiparesis (92%), and visual field deficits (85%) were the most frequently observed impairments in the first year following surgery. Most patients saw no change in developmental or cognitive-affective impairments at 1 (65%), 5 (85%), 10 (89%), and 15 years (80%) post-op compared to the previous time point. The only qualitative reports of decreased ability occurred in 2/26 patients whose medical records indicated decreased mobility at the 1-year mark. All further qualitative reports of ability in mobility, self-care, and communication domains indicated increases or no change in ability for all patients at each of the subsequent follow-up intervals. Exploration of the utilization of re/habilitative therapy services shows that 84% of patients received at least one therapy service at baseline, 100% at1 year, 92% at 5 years, 100% at 10 years, and 80% at 15 years post-op. Patients were followed, on average (m), by multiple medical specialist services at baseline (m = 2.58) as well as the 1- (m = 1.70), 5- (m = 2.15), 10- (m = 3.00) and 15-year (m = 3.40) follow-up intervals. Following hemispherotomy, 15 (53.6%) patients required an average of 2.21 additional surgeries. Most often required was orthopedic surgical intervention (n = 16 procedures), followed by shunt placement (n = 7) and revision (n = 14) targeting hydrocephalus., Significance: This retrospective study demonstrates expected increases in impairments such as hemiparesis and visual field deficits (i.e., homonymous hemianopia) in the context of increased activity and favorable seizure outcomes for 28 pediatric patients who underwent hemispherotomy for drug-resistant epilepsy. Most patients required rehabilitative therapies prior to surgery and continued to require these services post-operatively. Reported baseline functional status, the persistence of impairments following surgery, and comorbidities among this cohort underscore the medical complexity of this patient population and the importance of multidisciplinary care both pre-and post-operatively., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Inc. All rights reserved.)
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- 2023
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56. Electrocorticography reveals the dynamics of famous voice responses in human fusiform gyrus.
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Rhone AE, Rupp K, Hect JL, Harford E, Tranel D, Howard MA 3rd, and Abel TJ
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- Adult, Humans, Brain physiology, Temporal Lobe physiology, Recognition, Psychology physiology, Magnetic Resonance Imaging methods, Electrocorticography, Voice physiology
- Abstract
Voice and face processing occur through convergent neural systems that facilitate speaker recognition. Neuroimaging studies suggest that familiar voice processing engages early visual cortex, including the bilateral fusiform gyrus (FG) on the basal temporal lobe. However, what role the FG plays in voice processing and whether it is driven by bottom-up or top-down mechanisms is unresolved. In this study we directly examined neural responses to famous voices and faces in human FG with direct cortical surface recordings (electrocorticography) in epilepsy surgery patients. We tested the hypothesis that neural populations in human FG respond to famous voices and investigated the temporal properties of voice responses in FG. Recordings were acquired from five adult participants during a person identification task using visual and auditory stimuli from famous speakers (U.S. Presidents Barack Obama, George W. Bush, and Bill Clinton). Patients were presented with images of presidents or clips of their voices and asked to identify the portrait/speaker. Our results demonstrate that a subset of face-responsive sites in and near FG also exhibit voice responses that are both lower in magnitude and delayed (300-600 ms) compared with visual responses. The dynamics of voice processing revealed by direct cortical recordings suggests a top-down feedback-mediated response to famous voices in FG that may facilitate speaker identification. NEW & NOTEWORTHY Interactions between auditory and visual cortices play an important role in person identification, but the dynamics of these interactions remain poorly understood. We performed direct brain recordings of fusiform face cortex in human epilepsy patients performing a famous voice naming task, revealing the dynamics of famous voice processing in human fusiform face cortex. The findings support a model of top-down interactions from auditory to visual cortex to facilitate famous voice recognition.
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- 2023
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57. Responsive neurostimulation for pediatric patients with drug-resistant epilepsy: a case series and review of the literature.
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Curtis K, Hect JL, Harford E, Welch WP, and Abel TJ
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- Adolescent, Adult, Child, Electrodes, Implanted adverse effects, Humans, Multicenter Studies as Topic, Retrospective Studies, Seizures etiology, Treatment Outcome, Young Adult, Drug Resistant Epilepsy etiology, Drug Resistant Epilepsy surgery, Epilepsy therapy
- Abstract
Objective: Responsive neurostimulation (RNS) is a promising treatment for pediatric patients with drug-resistant epilepsy for whom resective surgery is not an option. The relative indications and risk for pediatric patients undergoing RNS therapy require further investigation. Here, the authors report their experience with RNS implantation and therapy in pediatric patients., Methods: The authors performed a retrospective chart review to identify patients implanted with RNS depth or strip electrodes for the treatment of drug-resistant epilepsy at their institution between 2020 and 2022. Patient demographics, surgical variables, and patient seizure outcomes (Engel class and International League Against Epilepsy [ILAE] reporting) were evaluated., Results: The authors identified 20 pediatric patients ranging in age from 8 to 21 years (mean 15 [SD 4] years), who underwent RNS implantation, including depth electrodes (n = 15), strip electrodes (n = 2), or both (n = 3). Patient seizure semiology, onset, and implantation strategy were heterogeneous, including bilateral centromedian nucleus (n = 5), mesial temporal lobe (n = 4), motor cortex or supplementary motor area (n = 7), or within an extratemporal epileptogenic zone (n = 4). There were no acute complications of RNS implantation (hemorrhage or stroke) or device malfunctions. One patient required rehospitalization for postoperative infection. At the longest follow-up (mean 10 [SD 7] months), 13% patients had Engel class IIB, 38% had Engel class IIIA, 6% had Engel class IIIB, 19% had Engel class IVA, 19% had Engel class IVB, and 6% had Engel class IVC outcomes. Using ILAE metrics, 6% were ILAE class 3, 25% were ILAE class 4, and 69% were ILAE class 5., Conclusions: This case series supports current literature suggesting that RNS is a safe and potentially effective surgical intervention for pediatric patients with drug-resistant epilepsy. The authors report comparable rates of serious adverse events to current RNS literature in pediatric and adult populations. Seizure outcomes may continue to improve with follow-up as stimulation strategy is refined and the chronic neuromodulatory effect evolves, as previously described in patients with RNS. Further large-scale, multicenter case series of RNS in pediatric patients with drug-resistant epilepsy are required to determine long-term pediatric safety and effectiveness.
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- 2022
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58. Subdural electrodes versus stereoelectroencephalography for pediatric epileptogenic zone localization: a retrospective cohort study.
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Remick M, Akwayena E, Harford E, Chilukuri A, White GE, and Abel TJ
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- Child, Electrodes, Implanted, Humans, Prospective Studies, Retrospective Studies, Stereotaxic Techniques, Treatment Outcome, Drug Resistant Epilepsy diagnosis, Drug Resistant Epilepsy surgery, Electroencephalography
- Abstract
Objective: The objective of this study was to compare the relative safety and effectiveness of invasive monitoring with subdural electrodes (SDEs) and stereoelectroencephalography (sEEG) in pediatric patients with drug-resistant epilepsy., Methods: A retrospective cohort study was performed in 176 patients who underwent invasive monitoring evaluations at UPMC Children's Hospital of Pittsburgh between January 2000 and September 2021. To examine differences between SDE and sEEG groups, independent-samples t-tests for continuous variables and Pearson chi-square tests for categorical variables were performed. A p value < 0.1 was considered statistically significant., Results: There were 134 patients (76%) in the SDE group and 42 (24%) in the sEEG group. There was a difference in the proportion with complications (17.9% in the SDE group vs 7.1% in the sEEG group, p = 0.09) and resection (75.4% SDE vs 21.4% sEEG, p < 0.01) between SDE and sEEG patients. However, there was no observable difference in the rates of postresection seizure freedom at 1-year clinical follow-up (60.2% SDE vs 75.0% sEEG, p = 0.55)., Conclusions: These findings reveal a difference in rates of surgical complications and resection between SDEs and sEEG. Larger prospective, multi-institutional pediatric comparative effectiveness studies may further explore these associations.
- Published
- 2022
- Full Text
- View/download PDF
59. Choroidal melanoma with synchronous Fuchs' adenoma and novel ATRX mutation.
- Author
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Harford E, Palmer JM, Glasson WJ, Warrier SK, Whitehead KJ, Brooks KM, Johansson PA, Hayward NK, and McGrath LA
- Abstract
Background: To report a case of Fuchs' adenoma occurring in an eye with a large choroidal melanoma. We have reviewed the literature to describe the clinical presentation, ultrasound characteristics and pathological features of these entities., Case Presentation: A 69-year-old Caucasian man presented with vision loss from a large choroidal melanoma. Enucleation showed an incidental Fuchs' adenoma in the same eye. Whole-exome sequence analysis was also performed on the patient's blood and melanoma, which showed a rarely-reported ATRX mutation., Conclusions: Fuchs' adenoma is an under-diagnosed benign age-related hyperplasia of the non-pigmented ciliary epithelium (NPCE). Given its location and characteristics, it can be mistaken for choroidal melanoma and clinicians are reminded how to differentiate between these pathologies and that they may co-exist., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
60. Children with persistent otitis media. Audiometric and tympanometric findings.
- Author
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McDermott JC, Giebink GS, Le CT, Harford ER, and Paparella MM
- Subjects
- Air, Auditory Threshold, Bone Conduction, Child, Humans, Acoustic Impedance Tests, Audiometry, Audiometry, Pure-Tone, Otitis Media physiopathology
- Abstract
Audiometric and tympanometric findings were compared among 129 patients with clinically manifest persistent otitis media (OM) with effusion. Ears with thick effusion (mucoid OM) had significantly larger air-bone gaps and higher prevalence of flat tympanograms than either of the thin effusion types (purulent [POM] or serous OM [SOM]) or ears with no effusion (dry). Ears with thin effusion (POM and SOM) had similar air-bone gaps, thresholds for air and bone conduction, and prevalences of flat and underpressure tympanograms. Ears with no effusion had significantly smaller air-bone gaps, slightly poorer bone conduction thresholds, and lower prevalence of flat tympanograms than ears with effusion (MOM, POM and SOM). Ears with clinically manifest OM and no effusion at tympanocentesis appear to represent patients with a spontaneously resolved episode of OM with thin effusion (POM or SOM) or with ears that evacuated during anesthesia prior to tympanostomy.
- Published
- 1983
- Full Text
- View/download PDF
61. The pediatric audiologist: from magician to clinician.
- Author
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Lidén G and Harford ER
- Subjects
- Audiometry methods, Auditory Threshold, Child, Child, Preschool, Combined Modality Therapy, Education, Special, Hearing Aids, Hearing Disorders therapy, Humans, Infant, Audiology trends, Hearing Disorders diagnosis
- Abstract
The tremendous progress of pediatric-audiology during the past 30 years is reviewed. Early identification of infants with impaired hearing is based on a high-risk register, screening behaviorally and/or brain stem audiometry. Since many hearing losses have a late onset, it is important to cooperate closely with pediatricians and well-baby clinics. To stimulate their interest in detection, use of a calibrated 3000 Hz warble tone instrument is suggested. Diagnostic tests for infants involve respiration, behavioral patterns, middle ear impedance, and brain stem audiometry. For young children, tangible reinforcement operant conditioning audiometry (TROCA) visual reinforcement audiometry (VRA), and play audiometry are the methods of choice. Due to medical progress, many of the high-risk factors have been ameliorated. Assessment of amplification for hearing impaired children is as sophisticated as for adults. The advantage of basing fitting procedures on functional gain is emphasized. Future goals in pediatric audiology are touched upon. Today, pediatric audiology has emerged from a mysterious beginning to a systematic clinical specialization.
- Published
- 1985
- Full Text
- View/download PDF
62. A new clinical technique for verification of hearing aid response.
- Author
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Harford ER
- Subjects
- Acoustics, Audiology instrumentation, Hearing Loss, Sensorineural rehabilitation, Humans, Audiology methods, Hearing Aids
- Abstract
A new miniature wide-range electret microphone with a flat frequency response is available to the audiology clinic to measure sound pressure in the patient's ear canal. This article describes the clinical application of this new microphone for the selection and monitoring of hearing aid response. Preliminary results of the relationship between ear canal measurements and functional gain are also provided. This new clinical technique can provide the audiologist with quick objective data on the response of a hearing aid while it is being worn by the patient.
- Published
- 1981
- Full Text
- View/download PDF
63. The acoustic reflex in eighth nerve disorders.
- Author
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Jerger J, Harford E, Clemis J, and Alford B
- Subjects
- Audiometry instrumentation, Auditory Threshold, Hearing Disorders diagnosis, Hearing Tests, Humans, Neural Conduction, Neurilemmoma diagnosis, Refractory Period, Electrophysiological, Cerebellopontine Angle, Neurilemmoma physiopathology, Reflex, Vestibulocochlear Nerve physiopathology
- Published
- 1974
- Full Text
- View/download PDF
64. Tympanometry.
- Author
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Giebink GS and Harford ER
- Subjects
- Child, Humans, Otitis Media with Effusion diagnosis, Acoustic Impedance Tests
- Published
- 1983
- Full Text
- View/download PDF
65. Automatic tympanometry in clinical practice.
- Author
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Lidén G, Harford E, and Hallén O
- Subjects
- Adult, Ear Diseases diagnosis, Ear Diseases physiopathology, Ear Ossicles, Electronics, Medical, Humans, Manometry, Muscles physiopathology, Otosclerosis diagnosis, Reflex, Audiometry, Ear, Middle physiopathology, Labyrinth Diseases diagnosis, Tympanic Membrane
- Published
- 1974
- Full Text
- View/download PDF
66. Guidelines for hearing problems: substituting management for myth.
- Author
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Harford ER
- Subjects
- Aged, Hearing Loss rehabilitation, Hearing Loss, Sensorineural rehabilitation, Humans, Hearing Aids, Hearing Loss therapy
- Published
- 1979
67. Versions of the CROS hearing aid.
- Author
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Harford E and Dodds E
- Subjects
- Amplifiers, Electronic, Functional Laterality, Humans, Terminology as Topic, Hearing Aids instrumentation
- Published
- 1974
- Full Text
- View/download PDF
68. The use of high-pass amplification for broad-frequency sensorineural hearing loss.
- Author
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Harford ER and Fox J
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Perceptual Masking, Speech, Deafness rehabilitation, Hearing Aids
- Abstract
Recent research suggests that persons with sensorineural hearing impairment should derive extra benefit from amplification that eliminates or greatly reduces low frequencies, i.e. frequencies below 1 500 or 2 000 Hz. Such amplification seems to reduce the detrimental effects of the upward spread of masking on speech intelligibility, especially when listening in noisy environments. Also, current research indicates that extended high-frequency amplification, between 4 000 and 6 500 Hz is especially beneficial for optimal speech intelligibility. 9 patients with a relatively flat, moderate to severe sensorineural hearing loss were evaluated in the clinic and for daily listening situations while wearing conventional broad-frequency hearing aids with an upper range of about 4 500 Hz. They were also evaluated under these same circumstances with a hearing aid that reduces low frequencies and extends the high frequencies to nearly 6 500 Hz. Results indicate that these patients performed better and perferred the hearing aid that extends the high and reduces the low frequencies, particularly in noisy places. As a group, they did not prefer this type of amplification in quite listening situations.
- Published
- 1978
69. Tympanometric configurations and middle ear findings in experimental otitis media.
- Author
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Giebink GS, Heller KA, and Harford ER
- Subjects
- Animals, Chinchilla, Disease Models, Animal, Pressure, Tympanic Membrane physiopathology, Acoustic Impedance Tests, Ear, Middle physiopathology, Otitis Media physiopathology
- Abstract
Relationships between ventilation of the middle ear (ME) system and pathogenic bacteria in the upper respiratory tract were explored in an animal model to better understand the etiopathogenesis of otitis media. Otitis media developed in 12 of 18 chinchillas inoculated intranasally with Streptococcus pneumoniae followed by bilateral ME deflation (negative pressure). Otitis media with effusion developed in 19 of 36 ears examined ten days after inoculation. The development of purulent effusion after ten days was highly correlated with persistent negative ME pressure for at least 48 hours after deflation, while most ears that developed serous effusion after ten days had normal ME pressure 48 hours after deflation. Tympanometric validation of the presence of absence of effusion and type of effusion was obtained ten days after inoculation. A low compliance tympanogram detected 90% of the purulent effusions and was 100% specific for this type of effusion. In contrast. three of four serous effusions were associated with normal pressure/normal compliance tracings suggesting that the physical characteristics or volume of ME effusion and/or the histopathology of the ME cleft are reflected i the tympanometric configuration.
- Published
- 1982
- Full Text
- View/download PDF
70. Modified earpieces and cros for high frequency hearing losses.
- Author
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Dodds E and Harford E
- Subjects
- Adolescent, Adult, Aged, Female, Hearing Tests, Humans, Male, Middle Aged, Hearing Aids
- Published
- 1968
- Full Text
- View/download PDF
71. Application of a lipreading test in a hearing aid evaluation.
- Author
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Dodds E and Harford E
- Subjects
- Aged, Audiometry, Female, Humans, Male, Middle Aged, Hearing Aids, Hearing Tests, Lipreading
- Published
- 1968
- Full Text
- View/download PDF
72. A special case of auditory localization. CROS for blind persons with unilateral hearing loss.
- Author
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Rintelmann W, Harford E, and Burchfield S
- Subjects
- Adult, Audiometry, Deafness complications, Environment, Female, Humans, Male, Blindness complications, Deafness rehabilitation, Hearing Aids standards
- Published
- 1970
- Full Text
- View/download PDF
73. The clinical diagnosis of Paget's disease of the temporal bone.
- Author
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Clemis JD, Boyles J, Harford ER, and Petasnick JP
- Subjects
- Adult, Aged, Audiometry, Deafness, Diagnosis, Differential, Facial Nerve physiopathology, Humans, Middle Aged, Radiography, Skull diagnostic imaging, Tomography, Vertigo, Osteitis Deformans diagnosis, Otosclerosis diagnosis, Temporal Bone
- Published
- 1967
- Full Text
- View/download PDF
74. On the detection of extremely small changes in sound intensity.
- Author
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JERGER J, SHEDD JL, and HARFORD E
- Subjects
- Humans, Hearing Tests, Sound
- Published
- 1959
- Full Text
- View/download PDF
75. Follow-up report on modified earpieces and CROS for high-frequency hearing losses.
- Author
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Dodds E and Harford E
- Subjects
- Follow-Up Studies, Humans, Deafness rehabilitation, Hearing Aids
- Published
- 1970
- Full Text
- View/download PDF
76. An analysis of patient attitudes and reactions to a clinical hearing aid selection program.
- Author
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Rassi J and Harford E
- Subjects
- Adolescent, Adult, Aged, Attitude, Consumer Behavior, Female, Humans, Male, Middle Aged, Counseling, Hearing Aids
- Published
- 1968
77. Alternate and simultaneous binaural balancing of pure tones.
- Author
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JERGER JF and HARFORD ER
- Subjects
- Humans, Hearing Tests
- Published
- 1960
- Full Text
- View/download PDF
78. A comparison of acoustic reflex and loudness growth in normal and pathological ears.
- Author
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Beedle RK and Harford ER
- Subjects
- Adult, Audiometry, Auditory Threshold, Ear, Middle physiology, Female, Humans, Male, Middle Aged, Pressure, Sound, Auditory Perception, Deafness, Ear, Middle physiopathology, Meniere Disease physiopathology, Reflex
- Published
- 1973
- Full Text
- View/download PDF
79. BINAURAL HEARING WITH ONE HEARING AID.
- Author
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HARFORD E and MUSKET CH
- Subjects
- Humans, Audiometry, Hearing, Hearing Aids, Otosclerosis, Stapes Surgery
- Published
- 1964
- Full Text
- View/download PDF
80. Tympanometry for the diagnosis of ossicular disruption.
- Author
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Lidén G, Harford E, and Hallén O
- Subjects
- Acoustic Stimulation, Adolescent, Adult, Bone Conduction, Ear Diseases physiopathology, Female, Humans, Male, Methods, Middle Aged, Audiometry, Ear Diseases diagnosis, Ear Ossicles physiopathology, Tympanic Membrane physiopathology
- Published
- 1974
- Full Text
- View/download PDF
81. Simultaneous recording of changes in relative impedance and air pressure during acoustic and non-acoustic elicitation of the middle-ear reflexes.
- Author
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Lidén G, Peterson JL, and Harford ER
- Subjects
- Ear, Middle physiopathology, Humans, Muscles, Pressure, Sound, Ear, Middle physiology, Otosclerosis physiopathology, Reflex
- Published
- 1969
- Full Text
- View/download PDF
82. The detection and assessment of pseudohypoacusis among school-age children.
- Author
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RINTELMANN W and HARFORD E
- Subjects
- Child, Humans, Hearing Disorders, Hearing Tests
- Published
- 1963
- Full Text
- View/download PDF
83. Tympanometry for Eustachian tube evaluation.
- Author
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Harford ER
- Subjects
- Cadaver, Child, Child, Preschool, Ear Diseases diagnosis, Electronics, Medical, Humans, Male, Manometry, Mass Screening, Middle Aged, Motion, Ear, Middle, Eustachian Tube, Tympanic Membrane physiology
- Published
- 1973
- Full Text
- View/download PDF
84. The clinical application of CROS. A hearing aid for unilateral deafness.
- Author
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Harford E and Dodds E
- Subjects
- Adult, Aged, Female, Humans, Male, Middle Aged, Deafness therapy, Hearing Aids
- Published
- 1966
- Full Text
- View/download PDF
85. Bilateral cros. Two sided listening with one hearing aid.
- Author
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Harford E
- Subjects
- Humans, Hearing Aids
- Published
- 1966
- Full Text
- View/download PDF
86. Hearing loss of sudden onset.
- Author
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JERGER J, ALLEN G, ROBERTSON D, and HARFORD E
- Subjects
- Humans, Deafness etiology, Hearing Loss
- Published
- 1961
- Full Text
- View/download PDF
87. A REHABILITATIVE APPROACH TO THE PROBLEM OF UNILATERAL HEARING IMPAIRMENT: THE CONTRALATERAL ROUTING OF SIGNALS CROS.
- Author
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HARFORD E and BARRY J
- Subjects
- Humans, Deafness, Hearing Aids, Hearing Loss, Hearing Loss, Unilateral, Rehabilitation
- Published
- 1965
- Full Text
- View/download PDF
88. Type V Bekesy pattern: interpretation and clinical utility.
- Author
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Rintelmann WF and Harford ER
- Subjects
- Adolescent, Adult, Child, Female, Humans, Male, Middle Aged, Audiometry classification, Hearing Disorders diagnosis, Pitch Discrimination
- Published
- 1967
- Full Text
- View/download PDF
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