728 results on '"Hamann C"'
Search Results
52. Impact vaporization and Condensation: Laser Irradiation Experiments with Natural Planetary Materials
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Hamann, C, Hecht, L, Schäffer, S, Heunoske, D, Salge, T, Garbout, A, Osterholz, J, and Greshake, A
- Abstract
0000-0002-4414-4917
- Published
- 2018
53. Preparation and Electrical Properties of Plasma Polymer Metal Composite Films
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Heilmann, A., primary and Hamann, C., additional
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- 1992
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54. Role of mast cells in the pathogenesis of postburn inflammatory response: reactive oxygen species as mast cell stimulators
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Santos, F.X, Arroyo, C, Garcı́a, I, Blasco, R, Obispo, J.M, Hamann, C, and Espejo, L
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- 2000
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55. Poor agreement in questionnaire-based diagnostic criteria for adult atopic dermatitis is a challenge when examining cardiovascular comorbidity
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Andersen, Y. M. F., primary, Egeberg, A., additional, Hamann, C. R., additional, Skov, L., additional, Gislason, G. H., additional, Skaaby, T., additional, Linneberg, A., additional, and Thyssen, J. P., additional
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- 2017
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56. Laserlöten mit dem CO2- und Nd-Laser
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Hamann, C., Rosen, H.-G., Scherer, C., and Waidelich, Wilhelm, editor
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- 1987
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57. Einfluß der Nahtvorbereitung auf die Schweißqualität im Multi-kW-Bereich
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Hamann, C., Rosen, H.-G., and Waidelich, Wilhelm, editor
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- 1986
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58. The reaction of carbonates in contact with superheated silicate melts
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Hamann, C., Hecht, L., Schäffer, S., Deutsch, A., Lexow, B., and Publica
- Abstract
Introduction: Carbonates are present in about one third of the known impact structures on Earth [1]. In contrast to silicates, they are believed to decompose into CO2, CaO, and MgO upon impact (e.g., [2]). Recently, the formation of carbonate melts has been postulated on the basis of petrographic observations for several impact structures (e.g., [1,3,4]). The salient point of these studies is the presence of round blebs and globules of calcite disseminated in silicate impact melt. These textures have been interpreted as being formed by liquid immiscibility, seemingly proving the coexistence of carbonate and silicate melts. However, evidence from terrestrial craters has been discussed quite controversially, as exemplified by contrasting studies on Meteor Crater [4,5]. Moreover, results from shock experiments and numerical modeling (e.g., [6,7]) suggest that both processes can occur. Here, we discuss the results of four laser melting experiments involving carbonates in contact with silicates, performed in the Multidisciplinary Experimental and Modeling Impact Research Network (MEMIN). Methods: We used a ytterbium fiber laser (8 kW, 1070 nm wavelength, operated in continuous-wave mode) at Fraunhofer-Institut für Kurzzeitdynamik, Freiburg, Germany, to rapidly melt and partially vaporize targets made of a silicate layer (sandstone or basalt, 0.5-1 cm thickness) attached onto a carbonate layer (Carrara marble or Savonnières limestone, 2 cm thickness). The laser penetrated through the silicate layer into the carbonate layer below, and the laser-matter interaction zone was recorded with a video camera, an infrared camera, and a high-speed camera. The reaction products were investigated after the experiments using a combination of optical microscopy, SEM, EMPA, and Raman spectroscopy. Results: In the sandstone experiments, the laser formed a pool of siliceous melt that quenched within ~18 s from >2100 to 500 °C (dT/dt ≈ 89 °C) to a transparent to milky glass. The glass is mainly a mixture of SiO2 and CaO that generally shows increasing CaO contents towards a carbonate reaction zone that lies below the silicate melt pool. Locally, silicate emulsions formed as the melt passed through a miscibility gap in the system SiO2-CaO. Moreover, pseudowollastonite, CaSiO3, crystallized close to the carbonate reaction front in the siliceous melt. In the basalt experiments, the laser formed a pool of basaltic melt on top of a carbonate reaction front as well, but penetrated much further into the carbonate layer. The basaltic melt in the marble experiment quenched within ~36 s from 1900 to 500 °C (dT/dt ≈ 29 °C/s) to a brown glass, whereas the marble at the irradiation area cooled within ~12 s from >2100 to 500 °C (dT/dt ≈ 133 °C/s). The basaltic melt is thoroughly homogenized, mimicking the bulk composition of the original basalt. However, it is distinctly enriched in CaO towards the carbonate reaction zone. Moreover, at the contact between basaltic melt and carbonate reaction front exists an assemblage of quenched, Ca,Fe,Alrich silicate melt, equant, idiomorphic, Si,Al-bearing calcite crystallites, lath-shaped, Ca,Si-rich, volatile-bearing quench crystals, and MgO. This assemblage resembles quenched immiscible silicate and carbonatite liquids known from quenching experiments (e.g., [8,9]). Moreover, merwinite, Ca3Mg(SiO4)2, crystallized in the basaltic melt close to the carbonate reaction front. Discussion: The formation of CaO-enriched silicate glasses and crystalline phases such as pseudowollastonite and merwinite document high-temperature reactions between the silicate melts and the molten or decomposed carbonates. Similar reaction products are known from the Haughton [10] and Chicxulub [11] impact structures. However, some textures observed in the basalt experiments are reminiscent of emulsion textures in silicate-carbonatite quenching experiments [8,9], suggesting the action of an immiscible carbonate melt phase that precipitated upon quenching so far unidentified Ca,Si-rich, volatile-bearing crystallites and equant, idiomorphic calcite crystallites. References: [1] Osinski G. R. and Grieve R. A. F. 2008. GSA Special Paper 437:1-17. [2] Kieffer S. W. and Simonds C. H. 1980. Reviews of Geophysics 18:413-181. [3] Graup G. 1999. Meteoritics & Planetary Science 34:425-438. [4] Osinski G. R. et al. 2015. Earth and Planetary Science Letters 432:283-292. [5] Hörz F. et al. 2015. Meteoritics & Planetary Science 50:1050-1070. [6] Langenhorst F. et al. 2002. High Pressure Shock Compression in Solids V. Springer, pp. 1-27. [7] Ivanov B. A. and Deutsch A. 2002. Physics of the Earth and Planetary Interiors 129:131-143. [8] Lee W. and Wyllie P. J. 1997. Contributions to Mineralogy and Petrology 127:1-16. [9] Brooker R. A. and Kjarsgaard B. A. 2011. Journal of Petrology 52:1281-1305. [10] Martinez I. et al. 1994. Earth and Planetary Science Letters 121:559-574. [11] Deutsch A. and Langenhorst F. 2007. GFF 129:155-160.
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- 2016
59. Atopic dermatitis is associated with anxiety, depression, and suicidal ideation, but not with psychiatric hospitalization or suicide
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Thyssen, J. P., primary, Hamann, C. R., additional, Linneberg, A., additional, Dantoft, T. M., additional, Skov, L., additional, Gislason, G. H., additional, Wu, J. J., additional, and Egeberg, A., additional
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- 2017
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60. Laser‐induced melting experiments: Simulation of short‐term high‐temperature impact processes
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Ebert, M., primary, Hecht, L., additional, Hamann, C., additional, and Luther, R., additional
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- 2017
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61. On Focus Encoding in Adult and Child Hebrew
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Eitan, R., Schaeffer, J., Hamann, C., Ruigendijk, E., and ACLC (FGw)
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- 2015
62. Adults' on-line comprehension of object pronouns in discourse
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Hendriks, P., Banga, A., Rij, J. van, Cannizzaro, G., Hoeks, J., Grimm, A., Müller, A., Hamann, C., Ruigendijk, E., Grimm, A., Müller, A., Hamann, C., and Ruigendijk, E.
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Cross linguistic studies (project of Numerosity in Dutch and related languages) ,Grammar and Cognition - Abstract
Contains fulltext : 94228.pdf (author's version ) (Open Access)
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- 2011
63. An asymmetry in the acquisition of accusative clitics in child Romanian
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Coene, M.M.R., Avram, L., Grimm, A., Müller, A., Hamann, C., Ruigendijk, E., Language and Communication, LEARN!, Grimm, A., Müller, A., Hamann, C., and Ruigendijk, E.
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Romanian ,media_common.quotation_subject ,language ,Psychology ,Asymmetry ,language.human_language ,Linguistics ,media_common - Published
- 2011
64. Chronic areolar dermatitis due to methylisothiazolinone-containing bodywash
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Hamann, C. R., primary, Brankov, N., additional, Hamann, D., additional, and Hamann, C., additional
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- 2015
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65. Magnetization dynamics of magnetic domain wall imprinted magnetic films
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Hamann, C., Mattheis, R., Mönch, I., Fassbender, J., Schultz, L., and McCord, J.
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magnetic excitation ,micromagnetic objects ,magnetism ,ion irradiation ,dynamics ,domain wall ,magnetic thin films - Abstract
The influence of micromagnetic objects on the dynamic magnetic excitation in magnetic thin films is studied by imprinting periodic domain wall patterns through selective ion irradiation in exchange biased Ni81Fe 19/IrMn structures. For high domain wall densities an increased precessional frequency is achieved. The zero field resonance of the domain wall state hereby depends directly on the stripe period, showing a pronounced increase with decrease of domain wall spacing. With the abrupt annihilation of magnetic domain walls with an applied bias field a jump-like decrease in precessional frequency takes place. The experimental data and micromagnetic simulations prove that the characteristic collective dynamic mode for the domain wall configurations is attributed to strongly coupled tilted magnetization structure. This is evidenced by an overlapping N��el wall structure for the narrowly spaced imprinted antiparallel unidirectional anisotropy state. The controlled introduction of high density frozen-in micromagnetic objects is a novel way to control the dynamic magnetic properties of continuous magnetic thin films.
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- 2014
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66. Projectile-target interaction during cratering in nature and experiment
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Hecht, L., Ebert, M., Hamann, C., Deutsch, A., Kenkmann, T., and Wirth, R.
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- 2014
67. New Fragrance Mix I formulation in TRUE Test
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Hamann, C., primary
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- 2016
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68. Atopic dermatitis and alcohol use - a meta-analysis and systematic review.
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Halling-Overgaard, A. -S., Hamann, C. R., Holm, R. P., Linneberg, A., Silverberg, J. I., Egeberg, A., and Thyssen, J. P.
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ATOPIC dermatitis , *ALCOHOL use in pregnancy , *MENTAL illness , *MEDICAL databases , *T helper cells - Abstract
While several maternal exposures have been associated with an increased risk of atopic dermatitis (AD) in offspring, the effect of alcohol use during pregnancy on the risk of AD in offspring is unclear. Furthermore, it is unclear whether adults with AD have an increased alcohol use, although other poor health behaviours have been associated with AD including smoking and physical inactivity as well as psychiatric disease. In this systematic review and meta-analysis, the association between alcohol use and AD was investigated in two ways: 1) whether alcohol use (drinkers versus abstainers) during pregnancy is associated with AD in offspring and 2) whether AD is associated with increased alcohol use. The medical databases PubMed, EMBASE and Web of Science were searched, and data extraction was carried out by two independent reviewers. Eighteen studies were included in the qualitative analysis (comparing alcohol drinkers to abstainers), and 12 studies were included in the quantitative analysis. There was a positive association between alcohol use during pregnancy and development of AD in offspring (pooled odds ratio [OR] 1.16; 95% confidence interval [CI] 1.09-1.24). However, there was no consistent association between AD in adults and adolescents and alcohol use (pooled OR 1.06; 95% CI 0.92-1.23). There is a need for future well-designed prospective studies to firmly establish the association between alcohol use and AD. [ABSTRACT FROM AUTHOR]
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- 2018
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69. Poor agreement in questionnaire‐based diagnostic criteria for adult atopic dermatitis is a challenge when examining cardiovascular comorbidity.
- Author
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Andersen, Y. M. F., Egeberg, A., Hamann, C. R., Skov, L., Gislason, G. H., Skaaby, T., Linneberg, A., and Thyssen, J. P.
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ATOPIC dermatitis treatment ,CARDIOVASCULAR disease prevention ,CLINICAL immunology ,ALLERGY treatment ,COMORBIDITY - Abstract
Abstract: Background: The association between atopic dermatitis (AD) and cardio‐metabolic risk factors is not yet established. Furthermore, no validated questionnaire‐based method of identifying adults with AD is currently available. Objectives: To assess the cardio‐metabolic risk in adults with a history of AD using 3 different questionnaire‐based diagnostic criteria. Methods: We utilized data from a general population study including questionnaire data and objective measurements of 9656 Danish adults. To identify adults with a history of AD, we used a question regarding physician‐diagnosed AD and 2 versions of the UK Working Party Diagnostic Criteria. Associations between AD status and cardio‐metabolic endpoints were estimated using survey weighted logistic and linear regression analysis. Results: We identified 462 (4.8%) adults with self‐reported physician‐diagnosed AD, whereas 903 (9.4%) and 226 (2.3%) had AD according to the UK Working Party Criteria when at least 2 and 3of 4 minor criteria were fulfilled. The populations were not comparable in terms of occurrence of cardio‐metabolic risk factors. For example, the prevalence of obesity was lower in participants with physician‐diagnosed AD but overall higher in UK 2/4 and UK 3/4. Conclusion: Due to the heterogeneity in the captured study populations in terms of the studied outcomes and absence of a gold standard, no conclusions regarding the cardio‐metabolic risk in adults with AD in a general population could be made. This study serves as an example of the challenges that are often encountered in questionnaire‐based epidemiologic studies and highlights the need of better definitions for this patient group. [ABSTRACT FROM AUTHOR]
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- 2018
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70. Comprehension and production of subject pronouns in child Dutch
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Koster, C., Hoeks, J.C.J., Hendriks, P., Grimm, Angela, Muller, A., Hamann, C., Ruigendijk, E., and Discourse and Communication
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- 2011
71. Adult's comprehension of object pronouns in discourse: An eye-tracking study
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Hendriks, P., Banga, A., van Rij, Jacolien, Cannizzaro, C.L., Hoeks, J.C.J., Grimm, Angela, Müller, A., Hamann, C., Ruigendijk, E., and Discourse and Communication
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- 2011
72. Does sentence complexity interfere with intelligibility in noise? evaluation of the oldenburg linguistically and audiologically controlled sentence test (OLACS)
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Uslar, V. N., Brand, T., Hanke, M., Rebecca Carroll, Ruigendijk, E., Hamann, C., and Kollmeier, B.
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- 2010
73. Computer-aided transrectal ultrasound: does prostate HistoScanning™ improve detection performance of prostate cancer in repeat biopsies?
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Hamann, Moritz Franz, primary, Hamann, C., additional, Trettel, A., additional, Jünemann, K P, additional, and Naumann, C M, additional
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- 2015
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74. 219 Comparison of perineal HistoScanning™ targeted prostate biopsy with transrectal systematic prostate biopsy: Impact on cancer detection
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Hamann, M.F., primary, Hamann, C., additional, Naumann, C., additional, Olzem, D., additional, Trettel, A., additional, and Jünemann, K.P., additional
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- 2015
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75. The magneto-optical gradient effect in an exchange-biased thin film: Experimental evidence for classical diffraction theory
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Schäfer, R., Hamann, C., McCord, J., Schultz, L., and Kamberský, V.
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Perpendicular magnetization ,Ferromagnetic crystals ,Gradient effect ,Incidence of light ,In-plane ,Magnetostatic energy ,Physics::Optics ,Magneto-optical ,Experimental evidence ,Surface magnetizations ,Optical polarization ,Diffraction theory ,Kerr effects ,Very thin films ,Experimental confirmation - Abstract
The magneto-optical gradient effect decorates the boundaries of in-plane domains even at perpendicular incidence of light in an optical polarization microscope. For its explanation, the classical magneto-optical diffraction theory was previously used to derive the effect from the same gyrotropic interaction as the Kerr effect. In order to explain the symmetry of the experimentally observed contrast on bulk ferromagnetic crystals, planar as well as perpendicular subsurface gradients in the magnetization had to be assumed. This was particularly needed when the surface magnetizations in neighboring domains pointed head-on and a gradient contrast appeared also in conditions of vanishing gyrotropic interaction at the surface. The gradient contrast in such conditions should not appear in very thin films where perpendicular magnetization gradients are not enforced by reduction of magnetostatic energy. Here we present the first experimental confirmation of this expectation, thus closing an experimental gap in verifying the predictions of the diffraction theory.
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- 2010
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76. Tuning the static and dynamic magnetization properties of exchange bias modulated thin films
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Hamann, C., McCord, J., Fassbender, J., Mattheis, R., Kaltofen, R., Schäfer, R., and Schultz, L.
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Condensed Matter::Materials Science ,patterning ,magnetism ,exchange bias ,microscopy ,magnetization dynamics ,hybrid structures - Abstract
Aiming for new magnetic properties, the lateral combination of different magnetic properties into hybrid magnetic thin film structures are of increasing interest. We investigated exchange bias patterned thin NiFe/IrMn films to correlate the static and dynamic magnetization processes of the artificial hybrid material to the intrinsic material properties. Arrays of stripes with modulated exchange bias, i.e. exchange bias strength and direction, and a periodicity of a few micrometers were created. Inductive magnetometry revealed a distinct influence of geometry and orientation on the magnetization loop yielding either single-step shifted hysteresis loops or two-step loops with exchange spring effect. By means of high resolution Kerr microscopy, this could be attributed to either coherently or separately reversed stripe magnetization. As for the dynamics, the films exhibited either multiple resonance frequencies (as superposition of the input properties) or a single hybrid resonance frequency. The acquired frequencies at zero bias field as well as according damping parameters could be varied by a factor of about two. The different phenomena are discussed in terms of direct exchange coupling via the extended NiFe film as well as quasi-magnetostatic interactions at the stripe interfaces.
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- 2009
77. Systemische Mastozytose - Eine seltene Ursache für Berstungsfrakturen bei jungen Patienten
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Krüger, A, Hamann, C, and Ruchholz, S
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ddc: 610 - Published
- 2008
78. Characterization of hybrid amorphous-partially crystalline thin films
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Martin, N., Hamann, C., McCord, J., Fassbender, J., Quandt, E., Gerber, A., Bigall, N., Eychmüller, A., and Schultz, L.
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Condensed Matter::Materials Science ,Quantitative Biology::Tissues and Organs ,Condensed Matter::Superconductivity ,magnetism ,crystalization ,hybrid materials ,ion implantation ,magnetic microscopy ,equipment and supplies ,human activities - Abstract
Amorphous FeCoBSi thin films with uniaxial anisotropy have been laterally structured by Co ion implantation into stripe arrays. The resulting multiphase samples were investigated regarding the magnetic properties. Hysteresis measurements revealed a large increase in coercivity of the implanted areas. By means of TEM investigations this could be attributed to formed crystallites in the amorphous matrix. Magneto-optical imaging was used to correlate the domain structure to the magnetic hysteresis. It is demonstrated that stripe orientation with respect to the magnetic easy axis governs the coupling between implanted and non implanted areas.
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- 2008
79. Organic Material for Holography
- Author
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Hamann, C., primary, Libera, L., additional, Pogoretskii, P. P., additional, Riedel, G., additional, Salkova, E. N., additional, Savchuk, A. V., additional, and Soskin, M. S., additional
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- 1980
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80. Fractalic Growth in Metal-Cluster Polymer Composite Films
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Heilmann, A., primary, Hamann, C., additional, and Uan, Do Ngoc, additional
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- 1988
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81. Electric Field-Induced Disorder-Order Transition in Organic Polycrystalline Films of Quasi-One-Dimensional Lead-Phthalocyanine
- Author
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Frauenheim, Th., primary, Hamann, C., additional, and Muller, M., additional
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- 1984
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82. Solar Cells of Schottky Type with Ni-PbPc Interface
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Verzimacha, Ya. I., primary, Kovalchuk, A. V., additional, Kurik, M. V., additional, Hamann, C., additional, and Mrwa, A., additional
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- 1984
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83. Reflection Spectra of Single Crystals of Copper Phthalocyanine of the β -Modification
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Kurik, M. V., primary, Hamann, C., additional, Starke, M., additional, and Tsikora, L . I., additional
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- 1980
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84. A Model of the Electrical Transport Phenomena in Imperfect Crystals of Copper Phthalocyanine
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Lehmann, G., primary and Hamann, C., additional
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- 1974
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85. A Model of the Electrical Transport Phenomena in Imperfect Crystals of Copper Phthalocyanine II. Surface States of Phthalocyanine Single Crystals
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Hamann, C., primary and Lehmann, G., additional
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- 1973
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86. Peierls Transition and Fluctuation Conductivity in Thin Lead-Phthalocyanine (PbPc) Films
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Müller, M., primary, Frauenheim, Th., additional, and Hamann, C., additional
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- 1985
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87. Switching Effects on Poylcrystalline Films of Lead Phthalocyanine (PbPc)
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Hamann, C., primary, Höhne, H.-J., additional, Kersten, F., additional, Müller, M., additional, Przyborowski, F., additional, and Starke, M., additional
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- 1978
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88. The Influence of an Electric Field on the Mobility in Semiconductors
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Burghardt, H., primary, Frauenheim, T., additional, and Hamann, C., additional
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- 1986
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89. Organische Leiter, Halbleiter und Photoleiter
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Hamann, C., primary, Heim, J., additional, and Burghardt, H., additional
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- 1980
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90. Photocells with Organic Semiconducting Material
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Verzimakha, Ya. I., primary, Kovalchuk, A. V., additional, Hamann, C., additional, Kurik, M. V., additional, and Muller, M., additional
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- 1982
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91. Growth of Single-Crystalline Regions on Amorphous Insulating Substrates by Zone-Melting Recrystallization
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Scharff, W., primary, Erben, J.-W., additional, Wolf, A., additional, Heber, M., additional, Hamann, C., additional, Weissmantel, C., additional, Voelskov, M., additional, Matthai, J., additional, Kögler, R., additional, Klabes, R., additional, and Wieser, E., additional
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- 1984
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92. Precision electroweak measurements on the Z resonance
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Schael, S, Barate, R, Bruneliere, R, Buskulic, D, Bonis, De, Decamp, I, Ghez, D, Goy, P, Jezequel, C, Lees, S, Lucotte, Jp, Martin, A, Merle, F, Minard, E, Nief, Mn, Odier, Jy, Pietrzyk, P, Trocme, B, Bravo, B, Casado, S, Chmeissani, Mp, Comas, M, Crespo, P, Fernandez, Jm, E, Fernandez, Bosman, Garrido, M, Grauges, L, Juste, E, Martinez, A, Merino, M, Miquel, G, Mir, R, Orteu, Lm, Pacheco, S, Park, A, Perlas, Ic, Riu, J, Ruiz, I, Sanchez, H, Colaleo, F, Creanza, A, D, Filippis, De, N, Palma, De, Iaselli, M, Maggi, G, Nuzzo, M, Ranieri, S, Raso, A, Ruggieri, G, Selvaggi, F, Silvestris, G, Tempesta, L, Tricomi, P, Zito, A, Huang, G, Lin, X, Ouyang, J, Wang, Q, Xie, T, Xu, Y, Xue, R, Zhang, S, Zhang, J, Zhao, L, Abbaneo, W, Bazarko, D, Becker, A, Boix, U, Bird, G, Blucher, F, Bonvicini, E, B, Bright, Thomas, Barklow, P, Buchmuller, T, Cattaneo, O, Cerutti, M, Ciulli, F, Clerbaux, V, Drevermann, B, Forty, H, Frank, Rw, Greening, M, Hagelberg, Tc, Halley, R, Gianotti, Aw, Girone, F, Hansen, M, Harvey, Jb, Jacobsen, J, Hutchcroft, R, Janot, De, Jost, R, Knobloch, B, Kado, J, Lehraus, M, Lazeyras, I, Maley, P, Mato, R, May, P, Moutussi, J, A, Pepe, Altarelli, Ranjard, M, Rolandi, F, Schlatter, L, Schmitt, D, Schneider, B, Tejessy, O, Teubert, W, Tomalin, F, Tournefier, Ir, Veenhof, E, Valassi, R, Wiedenmann, A, Wright, W, Ajaltouni, Ae, Badaud, Z, Chazelle, F, Deschamps, G, Dessagne, O, Falvard, S, Ferdi, A, Fayolle, C, Gay, D, Guicheney, P, Henrard, C, Jousset, P, Michel, J, Monteil, B, Montret, S, Pallin, Jc, Pascolo, D, Perret, Jm, Podlyski, P, Bertelsen, F, Fernley, H, Hansen, T, Hansen, Jd, Hansen, Jr, Kraan, Ph, Lindahl, Ac, Mollerud, A, Nilsson, R, Rensch, Bs, Waananen, B, Daskalakis, A, Kyriakis, G, Markou, A, Simopoulou, C, Siotis, E, Vayaki, I, Zachariadou, A, Blondel, K, Bonneaud, A, Brient, G, Machefert, Jc, Rouge, E, Rumpf, A, Swynghedauw, M, Tanaka, M, Verderi, R, Videau, M, Focardi, H, Parrini, E, Corden, G, Georgiopoulos, M, Antonelli, C, Antonelli, A, Bencivenni, M, Bologna, G, Bossi, G, Campana, F, Capon, P, Chiarella, G, Felici, V, Laurelli, G, Mannocchi, P, Murtas, G, Passalacqua, Gp, Picchi, L, Colrain, P, P, Ten, Have, Hughes, I, Kennedy, Is, Knowles, J, Lynch, Ig, Morton, Jg, Negus, Wt, Oshea, P., Raine, V, Reeves, C, Scarr, P, Smith, Jm, Thompson, K., Turnbull, As, Wasserbaech, Rm, Cavanaugh, S, Dhamotharan, R, Geweniger, S, Hanke, C, Hansper, P, Hepp, G, Kluge, V, Putzer, Ee, Sommer, A, Stenzel, J, Tittel, H, Werner, K, Wunsch, W, Beuselinck, M, Binnie, R, Cameron, Dm, Davies, W, Dornan, G, Goodsir, Pj, Marinelli, S, Martin, N, Nash, Eb, Nowell, J, Rutherford, J, Sedgbeer, Sa, Thompson, Jk, White, Jc, Williams, R, Ghete, Md, Girtler, Vm, Kneringer, P, Kuhn, E, Rudolph, D, G, Bouhova, Thacker, Bowdery, E, Buck, Ck, Clarke, Pg, Ellis, Dp, Finch, G, Foster, Aj, Hughes, F, Jones, G, Rwl, Keemer, Pearson, Nr, Robertson, Mr, Sloan, Na, Smizanska, T, Snow, M, Williams, Sw, van der Aa, Delaere, O, Leibenguth, C, Lemaitre, G, 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Thaler, Fe, Thom, Jj, Trandafir, J, Turk, Ai, Usher, Jd, Vavra, T, Vella, J, Venuti, E, Verdier, Jp, Wagner, R, Waite, Sr, Walston, Ap, Wang, S, Watts, J, Weidemann, Sj, Weiss, Aw, Whitaker, Er, White, Js, Wickens, Sl, Williams, Fj, Williams, Da, Williams, Dc, Willocq, Sh, Wilson, S, Wisniewski, Rj, Wittlin, Wj, Woods, Jl, Word, M, Wright, Gb, Wyss, Tr, Yamamoto, J, Yang, Rk, Yashima, Xq, Yellin, J, Young, Sj, Yuta, Cc, Zapalac, H, Zdarko, G, Zeitlin, Rw, Zhou, C, Blondel, Alain, Schael, S, Barate, R, Bruneliere, R, Spagnolo, Stefania Antonia, S., Schael, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Napolitano, Marco, Patricelli, Sergio, Sciacca, Crisostomo, Lista, Luca, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALEPH, DELPHI, L3, OPAL, SLD, BARBIELLINI AMIDEI, Guido, Bosisio, Luciano, DELLA RICCA, Giuseppe, Giannini, Gianrossano, Gregorio, Anna, Lanceri, Livio, Poropat, Paolo, Vitale, Lorenzo, Buskulic, D, De Bonis, I, Decamp, D, Ghez, P, Goy, C, Jezequel, S, Lees, J, Lucotte, A, Martin, F, Merle, E, Minard, M, Nief, J, Odier, P, Pietrzyk, B, Trocme, B, Bravo, S, Casado, M, Chmeissani, M, Comas, P, Crespo, J, Fernandez, E, Fernandez Bosman, M, Garrido, L, Grauges, E, Juste, A, Martinez, M, Merino, G, Miquel, R, Mir, L, Orteu, S, Pacheco, A, Park, I, Perlas, J, Riu, I, Ruiz, H, Sanchez, F, Colaleo, A, Creanza, D, De Filippis, N, De Palma, M, Iaselli, G, Maggi, G, Maggi, M, Nuzzo, S, Ranieri, A, Raso, G, Ruggieri, F, Selvaggi, G, Silvestris, L, Tempesta, P, Tricomi, A, Zito, G, Huang, X, Lin, J, Ouyang, Q, Wang, T, Xie, Y, Xu, R, Xue, S, Zhang, J, Zhang, L, Zhao, W, Abbaneo, D, Bazarko, A, Becker, U, Boix, G, Bird, F, Blucher, E, Bonvicini, B, Bright Thomas, P, Barklow, T, Buchmuller, O, Cattaneo, M, Cerutti, F, Ciulli, V, Clerbaux, B, Drevermann, H, Forty, R, Frank, M, Greening, T, Hagelberg, R, Halley, A, Gianotti, F, Girone, M, Hansen, J, Harvey, J, Jacobsen, R, Hutchcroft, D, Janot, R, Jost, B, Knobloch, J, Kado, M, Lehraus, I, Lazeyras, P, Maley, R, Mato, P, May, J, Moutussi, A, Pepe Altarelli, M, Ranjard, F, Rolandi, L, Schlatter, D, Schmitt, B, Schneider, O, Tejessy, W, Teubert, F, Tomalin, I, Tournefier, E, Veenhof, R, Valassi, A, Wiedenmann, W, Wright, A, Ajaltouni, Z, Badaud, F, Chazelle, G, Deschamps, O, Dessagne, S, Falvard, A, Ferdi, C, Fayolle, D, Gay, P, Guicheney, C, Henrard, P, Jousset, J, Michel, B, Monteil, S, Montret, J, Pallin, D, Pascolo, J, Perret, P, Podlyski, F, Bertelsen, H, Fernley, T, Hansen, P, Kraan, A, Lindahl, A, Mollerud, R, Nilsson, B, Rensch, B, Waananen, A, Daskalakis, G, Kyriakis, A, Markou, C, Simopoulou, E, Siotis, I, Vayaki, A, Zachariadou, K, Blondel, A, Bonneaud, G, Brient, J, Machefert, E, Rouge, A, Rumpf, M, Swynghedauw, M, Tanaka, R, Verderi, M, Videau, H, Focardi, E, Parrini, G, Corden, M, Georgiopoulos, C, Antonelli, A, Antonelli, M, Bencivenni, G, Bologna, G, Bossi, F, Campana, P, Capon, G, Chiarella, V, Felici, G, Laurelli, P, Mannocchi, G, Murtas, G, Passalacqua, L, Picchi, P, Colrain, P, Ten Have, I, Hughes, I, Kennedy, J, Knowles, I, Lynch, J, Morton, W, Negus, P, 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Vandalen, Gj, Virtue, Cj, Vokurka, Eh, Vollmer, Cf, Wagner, Dl, Walker, Jp, Ward, Cp, Ward, Dr, Watkins, Pm, Watson, At, Watson, Nk, Whalley, Ma, Wilson, Ja, Wilson, Gw, Winterer, Vh, Wood, Nc, Wyatt, Tr, Zorn, Gt, Allen, Nj, Ash, Ww, Baird, Kg, Band, Hr, Barakat, Mb, Baranko, Gj, Barklow, Tl, Bashindzhagian, Gl, Bauer, Jm, Bazarko, Ao, Benvenuti, Ac, Bilei, Gm, Bower, Gr, Brau, Je, Bugg, Wm, Burnett, Th, Burrows, Pn, Caldwell, Do, Chadwick, Gb, Cohn, Ho, Coller, Ja, Convery, Mr, Cowan, Rf, Coyle, Pa, Coyne, Dg, Damerell, Cj, de Groot, N, de Sangro, R, Dervan, Pj, Dong, Dn, Du, Pyc, Eisenstein, Bi, Fernandez, Jp, Fero, Mj, Friedman, Ji, Garwin, El, Hallewell, Gd, Hart, El, Hitlin, Dg, Huffer, Me, Hughes, Ew, Izen, Jm, Jackson, Dj, Jaros, Ja, Jiang, Zy, Johnson, Jr, Johnson, Ra, Kamyshkov, Ya, Kang, Hj, Kelsey, Mh, Kendall, Hw, Kim, Yd, Krishna, Nm, Labs, Jf, Lauber, Ja, Leith, Dwg, Liu, Mx, Lynch, Hl, Markiewicz, Tw, Mcgowan, Jf, Mckemey, Ak, Meadows, Bt, Mockett, Pm, Moffeit, Kc, 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MCGOWAN, A.K. MCKEMEY, B.T. MEADOWS, R. MESSNER, P.M. MOCKETT, K.C. MOFFEIT, T.B. MOORE, M. MORII, B. MOURS, D. MULLER, G. MUELLER, V. MURZIN, T. NAGAMINE, S. NARITA, U. NAUENBERG, H. NEAL, G. NESOM, M. NUSSBAUM, Y. OHNISHI, N. OISHI, D. ONOPRIENKO, L.S. OSBORNE, R.S. PANVINI, C.H.PARK, H. PARK, T.J. PAVEL, I. PERUZZI, L. PESCARA, M. PICCOLO, L. PIEMONTESE, E. PIERONI, K.T. PITTS, R.J. PLANO, R. PREPOST, C.Y. PRESCOTT, G. PUNKAR, J. QUIGLEY, B.N. RATCLIFF, K. REEVES, T.W. REEVES, J. REIDY, P.L. REINERTSEN, P.E. RENSING, L.S. ROCHESTER, J.E. ROTHBERG, P.C. ROWSON, J.J. RUSSELL, O.H. SAXTON, T. SCHALK, R.H. SCHINDLER, U. SCHNEEKLOTH, B.A. SCHUMM, J. SCHWIENING, A. SEIDEN, S. SEN, V.V. SERBO, L. SERVOLI, M.H. SHAEVITZ, J.T. SHANK, G. SHAPIRO, D.J. SHERDEN, K.D. SHMAKOV, C. SIMOPOULOS, N.B. SINEV, S.R. SMITH, M.B. SMY, J.A. SNYDER, M.D. SOKOLOFF, H. STAENGLE, A. STAHL, P. STAMER, H. STEINER, R. STEINER, M.G. STRAUSS, D. SU, F. SUEKANE, A. SUGIYAMA, A. SUZUKI, S. SUZUKI, M. SWARTZ, A. SZUMILO, T. TAKAHASHI, F.E. TAYLOR, J.J. THALER, J. THOM, E. TORRENCE, A.I. TRANDAFIR, J.D. TURK, T. USHER, J. VA VRA, C. VANNINI, E. VELLA, J.P. VENUTI, R. VERDIER, P.G. VERDINI, D.L. WAGNER, S.R. WAGNER, A.P. WAITE, S. WALSTON, J. WANG, S.J. WATTS, A.W. WEIDEMANN, E.R. WEISS, J.S. WHITAKER, S.L. WHITE, F.J. WICKENS, D.A. WILLIAMS, D.C. WILLIAMS, S.H. WILLIAMS, S. WILLOCQ, R.J. WILSON, W.J. WISNIEWSKI, J.L. WITTLIN, M. WOODS, G.B. WORD, T.R. WRIGHT, J. WYSS, R.K. YAMAMOTO, J.M. YAMARTINO, X.Q. YANG, J. YASHIMA, S.J. YELLIN, C.C.YOUNG, H.YUTA, G. ZAPALAC, R.W. ZDARKO, C. ZEITLIN, J. ZHOU, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), GRUNEVALD M, NEWALD M, SCHAEL S, BARATE R, BRUNELIE, RE R, BUSKULIC D, DE BONIS I, DECAMP D, GHEZ P, GOY C, JE, ZE, QUEL S, LEES J, LUCOTTE A, MARTIN M, MERLE E, MINARD M, NIEF J, ODIER P, PIETRZYK B, TROCME, BRAVO S, CASADO MP, CHMEISSANI M, COMAS P, CRESPO JM, FERNANDEZ E, FERNANDEZ-BOSMAN M, GARRIDO L, GRAUGES E, JUSTE A, MARTINEZ M, MERINO G, MIQUEL R, MIR LM, ORTEU S, PACHECO A, PARK IC, PERLAS J, RIU I, RUIZ H, SANCHEZ F, COLALEO A, CREANZA D, DE FILIPPIS N, DE PALMA M, IASELLI G, MAGGI G, MAGGI M, NUZZO S, RANIERI, A, RASO, G, RUGGIERI F, SELVAGGI, G, SILVESTRIS L, TEMPESTA P, TRICOMI A, ZITO G, HUANG X, LIN J, OUYANG Q, WANG T, XIE Y, XU R, XUE S, ZHANG J, ZHANG L, ZHAO W, ABBANEO D, BAZARKO A, BECKER U, BOIX G, BIRD F, BLUCHER E, BONVICINI B, BRIGHT-THOMAS P, BARKLOW T, BUCHMU, LLER O, CATTANEO M, CERUTTI F, CIULLI V, CLERBAUX B, DREVERMANN H, FORTY RW, FRANK M, GREENING TC, HAGELBERG R, HALLEY AW, GIANOTTI F, GIRONE M, HANSEN JB, HARVEY J, JACOBSEN J, HUTCHCROFT DE, JANOT P, JOST B, KNOBLOCH J, KADO M, LEHRAUS I, LAZEYRAS P, and MALEY P
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Top quark ,FORWARD-BACKWARD ASYMMETRY ,PARTICLE PHYSICS ,LARGE ELECTRON POSITRON COLLIDER ,ALEPH ,DELPHI ,L3 ,OPAL ,General Physics and Astronomy ,01 natural sciences ,7. Clean energy ,High Energy Physics - Experiment ,Settore FIS/04 - Fisica Nucleare e Subnucleare ,High Energy Physics - Experiment (hep-ex) ,High Energy Physics - Phenomenology (hep-ph) ,electron-positron physics ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Electroweak interaction ,Physics ,Quantum chromodynamics ,Electron–positron physics ,Electroweak interactions ,Decays of heavy intermediate gauge bosons ,Fermion–antifermion production ,Precision measurements at the Z resonance ,Tests of the Standard Model ,Radiative corrections ,Effective coupling constants ,Neutral weak current ,Z boson ,W boson ,Higgs boson ,Particle physics - Experiment ,Settore FIS/01 - Fisica Sperimentale ,FERMION-PAIR PRODUCTION ,HADRONIC-Z-DECAYS ,TOP-QUARK MASS ,ANGLE BHABHA SCATTERING ,W-BOSON MASS ,CROSS-SECTION ASYMMETRY ,Z-LINE-SHAPE ,SEMILEPTONIC BRANCHING RATIOS ,CARLO EVENT GENERATOR ,decays of heavy intermediate gauge bosons ,effective coupling constants ,electroweak interactions ,fermion-antifermion production ,higgs boson ,neutral weak current ,precision measurements at the z resonance ,radiative corrections ,tests of the standard model ,top quark ,w boson ,z boson ,Radiative correction ,High Energy Physics - Phenomenology ,FIS/01 - FISICA SPERIMENTALE ,Física nuclear ,Neutrino ,Particle physics ,FOS: Physical sciences ,ddc:500.2 ,Elementary particle physics ,LEP ,electroweak ,Decays of heavy intermediate gauge boson ,Effective coupling constant ,Partícules (Física nuclear) ,Standard Model ,electroweak theory, Z boson, DELPHI, ALEPH, OPAL, L3 ,0103 physical sciences ,010306 general physics ,Coupling constant ,010308 nuclear & particles physics ,High Energy Physics::Phenomenology ,Fermion ,FORWARD-BACKWARD ASYMMETRY, FERMION-PAIR PRODUCTION, HADRONIC-Z-DECAYS, TOP-QUARK MASS, ANGLE BHABHA SCATTERING, W-BOSON MASS, CROSS-SECTION ASYMMETRY, Z-LINE-SHAPE, SEMILEPTONIC BRANCHING RATIOS, CARLO EVENT GENERATOR ,[PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph] ,Experimental High Energy Physics ,Electron–positron physic ,High Energy Physics::Experiment ,FIS/04 - FISICA NUCLEARE E SUBNUCLEARE - Abstract
We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $\MZ$ and $\GZ$, and its couplings to fermions, for example the $\rho$ parameter and the effective electroweak mixing angle, are precisely measured. The number of light neutrino species is determined to be 2.9840+/-0.0082. The results are compared to the predictions of the Standard Model. Electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its Standard Model expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the masses of the top quark and the W Boson are predicted. These indirect constraints are compared to the direct measurements, providing a stringent test of the Standard Model. Using in addition the direct measurements of $\Mt$ and $\MW$, the mass of the as yet unobserved Standard Model Higgs boson is predicted., Comment: 302 pages, v2: minor corrections and updates of references. Accepted for publication by Physics Reports, v3: further small corrections and journal version
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- 2006
93. CSF levels of total tau protein, phosphorylated tau epitopes 181, 199 and 231 as markers for early-onset Alzheimer's dementia
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Boban, M., Grbic, K., Hof, P. R., Hamann, C., Ackl, N., Bader, B., Danek, A., and Goran Šimić
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mental disorders ,Alzheimer's disease ,tau protein ,cerebrospinal fluid ,early-diagnosis ,biological markers - Abstract
Abnormal hyperphosphorylation of the microtubule-associated protein tau and its incorporation into neurofibrillary tangles are major hallmarks of the pathogenesis of Alzheimer's disease (AD). The cerebrospinal fluid (CSF) levels of phosphorylated tau proteins reflect the phosphorylation state of tau in the brain. Using monoclonal antibodies, different tau phosphoepitopes can be sensitively detected in CSF. To determine the diagnostic value of CSF total tau protein (t-tau), tau protein phosphorylated at threonine 181, 199 and 231 (p-tau-181, p-tau-199, p-tau-231) in early onset Alzheimer disease (AD) versus other primary causes of dementia (such as frontotemporal dementia (FTD)). Patients with clinical diagnosis of MCI (mild cognitive impairment), probable and possible AD, as well as FTD and nondemented controls were included in the study. CSF levels of t-tau, p-tau-181, p-tau-199, p-tau-231 were measured using commercially available ELISA kits (Invitrogen-Biosource, Camarillo, CA, USA). Mean CSF t-tau and CSF p-tau-181 levels were significantly elevated in AD patients compared to FTD patients and control subjects. Additionally, in differentiation between AD and FTD, CSF p-tau 181 showed best sensitivity and specificity. Our preliminary results in a rather small group of patients with AD and FTD confirmed earlier findings that p-tau-181 may be an useful, promising biological marker for distinguishing primary causes of dementia (e.g. AD from FTD).
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- 2006
94. CSF tau proteins in evaluation of patients with suspected dementia
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Goran Šimić, Boban, M., Sarac, H., Grbic, K., Hof, P. R., Hamann, C., Ackl, N., Bader, B., Danek, A., Weis, J, Hanin, Israel et al., Fisher, A, Hanin, I, Poewe W, and Windisch, M
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mental disorders ,Alzheimer's disease ,cerebrospinal fluid ,early diagnosis ,tau proteins ,frontotemporal dementia ,vascular dementia ,Lewy-body disease ,Creutzfeld-Jacob disease ,mild cognitive impairment ,ELISA ,CSF ,Tau proteins ,Dementia suspected patients ,AD - Abstract
The cerebrospinal fluid (CSF) levels of phosphorylated tau proteins reflect the phosphorylation state of tau in the brain. Using monoclonal an-tibodies, different tau phospho-epi-topes can be sensitively detected in CSF of dementia-suspected patients. Our objective was to determine the di-agnostic value of CSF total tau protein (t-tau) and tau protein phos-phorylated at threonine 181 and 199 (p-taul81 and p-taul99) in early-on-set Alzheimer's disease (AD) versus healthy controls (HC) and other primaj causes of dementia, such as frontotemporal dementia (FTD), vas-cular dementia (VaD) and diffuse Lewy-body disease (DLBD). The study included patients with a clinical diagnosis of suspected dementia, probable and possible AD (n = 11), as well as FTD (n = 5), VaD (n = 8), DLBD (n = 2) and HC (n - 12). CSF levels were measured using commer-cially available ELISA kits (t-tau and p-taul99 - BioSource, Camarillo, CA, USA and p- taul81 - Innogenet-ics, Ghent, Belgium). Mean CSF t-tau and CSFp-tau 181 levels were signifi-cantly elevated in AD patients com-pared to FTD, VaD and HC. In differ-entiating between AD versus FTD and VaD, CSF p-tau!81 showed best sensitivity and specificity (AD vs DLB: sens. 91%, spec. 94% ; AD vs VaD: sens. 91%, spec. 95%). P-taul99 showed much lower specificity. Total tau and p-tau 181 are useful biological markers for distinguishing AD from other primary causes of dementia, such as FTD and VaD. The time has come to include CSF examination of tau proteins as part of the routine di-agnostic workup for patients with suspected dementia in both clinical and neuropathological evaluation of a patient.
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- 2006
95. Organische Halbleiter
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Hamann, C., primary
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- 1965
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96. Electric and Photoelectric Investigations on Surfaces of Copper Phthalocyanine Single Crystals
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Hamann, C., primary
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- 1972
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97. Zur Textur von Aufdampfschichten des Kupferphthalocyanins
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Hamann, C, primary and Wagneb, H, additional
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- 1971
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98. Measurements of the Thermoelectric Power of Copper Phthalocyanine Single Crystals
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Hamann, C., primary
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- 1972
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99. Gleichrichtereigenschaften von Phthalooyaninen
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Hamann, C., primary
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- 1964
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100. Untersuchungen über die elektrischen und thermoelektrischen Eigenschaften der Modifikationen des metallfreien Phthalocyanins
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Hamann, C., primary and Starke, M., additional
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- 1964
- Full Text
- View/download PDF
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