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52. Selection of Patients in Ongoing Clinical Trials on Lung Cancer

Author

Schulkes, Karlijn J.G., Nguyen, Cindy, van den Bos, Frederiek, van Elden, Leontine J.R., and Hamaker, Marije E.

Subjects
Clinical trials -- Usage -- Research, Lung cancer -- Care and treatment -- Research, Health
Abstract

Background Lung cancer is predominantly a disease of the elderly: half of all newly diagnosed patients are over 70 years old. Older patients and those with comorbidities are underrepresented in clinical trials; scientific communities have addressed this issue since the end of the 20th century. We set out to determine the characteristics of the selection of patients in lung cancer trials that are currently recruiting. Methods We searched The United States National Institutes of Health (NIH) clinical trial registry (http://www.clinicaltrials.gov http://www.clinicaltrials.gov ) on April 23, 2015 for currently recruiting phase I, II, or III clinical trials in lung cancer. Trial characteristics and study objectives were extracted from the registry website. Results Of the 419 trails selected in this overview, 88 % explicitly or implicitly excluded elderly patients. Patients were excluded based on stringent organ selection in 76 % of the trials, based on performance status (57 %) and based on age (13 %). The median number of placed restrictions per trial was seven. In the 2 % of the trials that were exclusively designed for elderly patients only fit patients were included. Conclusion In this overview of current lung cancer trials registered in the NIH clinical trial registry, we found that elderly patients and those with comorbidities are often excluded from participation in clinical trials. Therefore, it is difficult for physicians and their frail patients to properly evaluate the efficacy and safety of current treatment options. More research that includes the elderly and those with comorbidities is urgently needed., Author(s): Karlijn J.G. Schulkes[sup.1] , Cindy Nguyen[sup.1] , Frederiek van den Bos[sup.2] , Leontine J.R. van Elden[sup.3] , Marije E. Hamaker[sup.4] Author Affiliations: (1) Department of Internal Medicine, Diakonessenhuis Utrecht, [...]

Published
2016
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53. Patient-Centered Outcome Measures in Lung Cancer Trials

Author

Schulkes, Karlijn J. G., Nguyen, Cindy, van den Bos, Frederiek, Hamaker, Marije E., and van Elden, Leontine J. R.

Subjects
Clinical trials -- Usage -- Research, Lung cancer -- Care and treatment -- Patient outcomes -- Research, Treatment outcome -- Research, Health
Abstract

Background Scientific communities focusing on cancer research have urged for the development of trials that address patient-centered outcome measures instead of solely focusing on cancer as a disease-centered process. This is important for a patient with lung cancer because of the rapid course of disease and generally poor prognosis. We set out to determine the characteristics and study objectives of the current clinical trials in pulmonary malignancies. Methods The United States National Institutes of Health clinical trial registry was searched on April 23rd 2015, for currently recruiting phase I, II, or III clinical trials in lung cancer. Trial characteristics and study objectives were extracted from the registry website. Results Of the 419 clinical trials included in this review, patient-centered outcome measures are investigated in a minority of the trials. Outcome measures as quality of life, functional capacity, and health care utilization are included in a small number of trials (20, 4, and 2 % respectively). Treatment completion is included in 1 % of the trials. Research goals are most frequently toxicity (78 %) and progression-free survival (76 %). Conclusion Patient-centered outcome measures are included in a minority of the currently recruiting clinical trials in pulmonary malignancies. If we do not investigate these outcome measures, it is not possible to increase our knowledge of the optimal treatment, as this should aim to optimize the patient's wellbeing as well as the course of disease. One option could be to incorporate combinations of patient- and disease-centered endpoints, for instance by using overall treatment utility or quality-adjusted outcome measures., Author(s): Karlijn J. G. Schulkes[sup.1] [sup.2] , Cindy Nguyen[sup.3] , Frederiek van den Bos[sup.4] , Marije E. Hamaker[sup.1] , Leontine J. R. van Elden[sup.2] Author Affiliations: (1) Department of Geriatric [...]

Published
2016
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61. The impact of surgery and adjuvant chemotherapy on health-related quality of life in patients with colon cancer: Changes at group level versus individual level

Author

Onderzoek Medische Oncologie, Cancer, MS Geriatrie, Circulatory Health, Scheepers, Ellen R M, Vink, Geraldine R, Schiphorst, Anandi H W, Emmelot-Vonk, Marielle H, van Huis-Tanja, Lieke H, Hamaker, Marije E, Onderzoek Medische Oncologie, Cancer, MS Geriatrie, Circulatory Health, Scheepers, Ellen R M, Vink, Geraldine R, Schiphorst, Anandi H W, Emmelot-Vonk, Marielle H, van Huis-Tanja, Lieke H, and Hamaker, Marije E

Published
2022

62. Frailty and health related quality of life three months after non-metastatic colorectal cancer diagnosis in older patients: A multi-centre prospective observational study

Author

Onderzoek, MS Radiotherapie, Cancer, Onderzoek Medische Oncologie, MS CGO, Infection & Immunity, van der Vlies, Ellen, Vernooij, Lisette M, Hamaker, Marije E, van der Velden, Ankie M T, Smits, Marianne, Intven, Martijn P W, van Dodewaard, Joyce M, Takkenberg, Marijn, Vink, Geraldine R, Smits, Anke B, Bos, Willem Jan W, van Dongen, Eric P A, Los, Maartje, Noordzij, Peter G, Onderzoek, MS Radiotherapie, Cancer, Onderzoek Medische Oncologie, MS CGO, Infection & Immunity, van der Vlies, Ellen, Vernooij, Lisette M, Hamaker, Marije E, van der Velden, Ankie M T, Smits, Marianne, Intven, Martijn P W, van Dodewaard, Joyce M, Takkenberg, Marijn, Vink, Geraldine R, Smits, Anke B, Bos, Willem Jan W, van Dongen, Eric P A, Los, Maartje, and Noordzij, Peter G

Published
2022

75. Amerikaanse richtlijn voor geriatrische oncologie

Author

Portielje, Johanneke E A, Hamaker, Marije E, Maas, Huub A A M, van Leeuwen, Barbara L, and van den Bos, Frederiek

Subjects
Journal Article, English Abstract
Abstract

American guideline for geriatric oncology; applicable to Dutch clinical practice? The American Society of Clinical Oncology (ASCO) has recently issued a guideline for geriatric oncology that provides guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. The recommendations are discussed and a practical framework for implementation in Dutch oncology practice is described.

Published
2019

76. Impact of Lung Cancer Treatment on Cognitive Functioning

Author

Unit Opleiding Geriatrie, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, van de Kamp, Henrieke J., Molder, Marthe te, Schulkes, Karlijn J.G., Stellingwerf, Margriet, van Elden, Leontine J.R., van Lindert, Anne S.R., Hamaker, Marije E., Unit Opleiding Geriatrie, Arts Assistenten Longziekten, Longziekten, Infection & Immunity, van de Kamp, Henrieke J., Molder, Marthe te, Schulkes, Karlijn J.G., Stellingwerf, Margriet, van Elden, Leontine J.R., van Lindert, Anne S.R., and Hamaker, Marije E.

Published
2020

77. Do age and comorbidity impair recovery during two years after treatment for endometrial cancer?

Author

MS Geriatrie, Circulatory Health, van Walree, Inez C, Hamaker, Marije E, de Rooij, Belle H, Boll, Dorry, van Huis-Tanja, Lieke H, Emmelot-Vonk, Marielle H, Ezendam, Nicole P M, MS Geriatrie, Circulatory Health, van Walree, Inez C, Hamaker, Marije E, de Rooij, Belle H, Boll, Dorry, van Huis-Tanja, Lieke H, Emmelot-Vonk, Marielle H, and Ezendam, Nicole P M

Published
2020

78. Clinical judgment versus geriatric assessment for frailty in older patients with cancer

Author

MS Geriatrie, Cancer, Circulatory Health, van Walree, Inez C, Scheepers, Ellen R M, van den Bos, Frederiek, van Huis-Tanja, Lieke H, Emmelot-Vonk, Marielle H, Hamaker, Marije E, MS Geriatrie, Cancer, Circulatory Health, van Walree, Inez C, Scheepers, Ellen R M, van den Bos, Frederiek, van Huis-Tanja, Lieke H, Emmelot-Vonk, Marielle H, and Hamaker, Marije E

Published
2020

80. Systematic comprehensive geriatric assessment in elderly patients on chronic dialysis: a cross-sectional comparative and feasibility study

Author

Parlevliet Juliette L, Buurman Bianca M, Pannekeet Marja M, Boeschoten Els M, ten Brinke Lucia, Hamaker Marije E, van Munster Barbara C, and de Rooij Sophia E

Subjects
Diseases of the genitourinary system. Urology, RC870-923
Abstract

Abstract Background Elderly dialysis patients are prone to disabilities and functional decline. This aggravates their last period of life. It would be valuable to be able to preserve daily function and quality of life. Identification of domains requiring additional attention is not common practice in standard care. Therefore, we performed a systematic Comprehensive Geriatric Assessment (CGA) to assess physical and psychosocial function and tested its feasibility in daily practice. The CGA is used more frequently in the assessment of elderly cancer patients, and we therefore compared the outcomes to this group. Methods A cross-sectional, multicenter study, between June 1st and September 31st, 2009, in four Dutch outpatient dialysis units. Fifty patients aged 65 years or above who received dialysis because of end-stage renal disease (ESRD) were randomly included. We assessed the CGA during a systematic interview with patients and their caregivers. The cancer patients had had a similar CGA in an earlier study. We compared prevalences between groups. Results In the dialysis population (68.0% 75 years or above, 76.6% on haemodialysis) caregivers often observed behavioral changes, such as deviant eating habits (34.0%) and irritability (27.7%). In 84.4%, caregivers felt overburdened by the situation of their family member. Somatic and psychosocial conditions were frequently found (polypharmacy (94.6%), depression (24.5%)) and prevalence of most geriatric conditions was comparable to those in elderly cancer patients. Conclusions Geriatric conditions were highly prevalent among elderly dialysis patients and prevalences were comparable in both populations. The CGA proved feasible for recognition of these conditions and of overburdened caregivers. This could prevent further functional decline and preserve quality of life.

Published
2012
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81. Association of Initiation of Maintenance Dialysis with Functional Status and Caregiver Burden

Author

Goto, Namiko A., primary, van Loon, Ismay N., additional, Boereboom, Franciscus T.J., additional, Emmelot-Vonk, Marielle H., additional, Willems, Hanna C., additional, Bots, Michiel L., additional, Gamadia, Laila E., additional, van Bommel, Eric F.H., additional, Van de Ven, Peter J.G., additional, Douma, Caroline E., additional, Vincent, Hieronymus H., additional, Schrama, Yvonne C., additional, Lips, Joy, additional, Hoogeveen, Ellen K., additional, Siezenga, Machiel A., additional, Abrahams, Alferso C., additional, Verhaar, Marianne C., additional, and Hamaker, Marije E., additional

Published
2019
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83. The impact of colorectal surgery on health-related quality of life in older functionally dependent patients with cancer - A longitudinal follow-up study

Author

Souwer, Esteban T D, Oerlemans, Simone, van de Poll-Franse, Lonneke V, van Erning, Felice N, van den Bos, Frederiek, Schuijtemaker, Johan S, van den Berkmortel, Franchette W P J, Ten Bokkel Huinink, Daan, Hamaker, Marije E, Dekker, Jan Willem T, Wientjes, Caroline A, Portielje, Johanna E A, Maas, Huub A A, Souwer, Esteban T D, Oerlemans, Simone, van de Poll-Franse, Lonneke V, van Erning, Felice N, van den Bos, Frederiek, Schuijtemaker, Johan S, van den Berkmortel, Franchette W P J, Ten Bokkel Huinink, Daan, Hamaker, Marije E, Dekker, Jan Willem T, Wientjes, Caroline A, Portielje, Johanna E A, and Maas, Huub A A

Published
2019

84. Association of initiation of maintenance dialysis with functional status and caregiver burden

Author

Goto, Namiko A., Van Loon, Ismay N., Boereboom, Franciscus T.J., Emmelot-Vonk, Marielle H., Willems, Hanna C., Bots, Michiel L., Gamadia, Laila E., Van Bommel, Eric F.H., Van De Ven, Peter J.G., Douma, Caroline E., Vincent, Hieronymus H., Schrama, Yvonne C., Lips, Joy, Hoogeveen, Ellen K., Siezenga, Machiel A., Abrahams, Alferso C., Verhaar, Marianne C., Hamaker, Marije E., Goto, Namiko A., Van Loon, Ismay N., Boereboom, Franciscus T.J., Emmelot-Vonk, Marielle H., Willems, Hanna C., Bots, Michiel L., Gamadia, Laila E., Van Bommel, Eric F.H., Van De Ven, Peter J.G., Douma, Caroline E., Vincent, Hieronymus H., Schrama, Yvonne C., Lips, Joy, Hoogeveen, Ellen K., Siezenga, Machiel A., Abrahams, Alferso C., Verhaar, Marianne C., and Hamaker, Marije E.

Published
2019

85. Geriatric Assessment and the Relation with Mortality and Hospitalizations in Older Patients Starting Dialysis

Author

van Loon, Ismay N, Goto, Namiko A, Boereboom, Franciscus T J, Bots, Michiel L, Hoogeveen, Ellen K, Gamadia, Laila, van Bommel, E F H, van de Ven, P J G, Douma, Caroline E, Vincent, H H, Schrama, Yvonne C, Lips, Joy, Siezenga, Machiel A, Abrahams, Alferso C, Verhaar, Marianne C, Hamaker, Marije E, van Loon, Ismay N, Goto, Namiko A, Boereboom, Franciscus T J, Bots, Michiel L, Hoogeveen, Ellen K, Gamadia, Laila, van Bommel, E F H, van de Ven, P J G, Douma, Caroline E, Vincent, H H, Schrama, Yvonne C, Lips, Joy, Siezenga, Machiel A, Abrahams, Alferso C, Verhaar, Marianne C, and Hamaker, Marije E

Published
2019

86. Geriatric assessment in elderly patients with end-stage kidney disease

Author

Goto, Namiko A., Van Loon, Ismay N., Morpey, Moira I., Verhaar, Marianne C., Willems, Hanna C., Emmelot-Vonk, Mariëlle H., Bots, Michiel L., Boereboom, Franciscus T.J., Hamaker, Marije E., Goto, Namiko A., Van Loon, Ismay N., Morpey, Moira I., Verhaar, Marianne C., Willems, Hanna C., Emmelot-Vonk, Mariëlle H., Bots, Michiel L., Boereboom, Franciscus T.J., and Hamaker, Marije E.

Published
2019

87. Medical decision making for older patients during multidisciplinary oncology team meetings

Author

Organisation Studies, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, Bolle, Sifra, Smets, Ellen M.A., Hamaker, Marije E., Loos, Eugène F., van Weert, Julia C.M., Organisation Studies, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, Bolle, Sifra, Smets, Ellen M.A., Hamaker, Marije E., Loos, Eugène F., and van Weert, Julia C.M.

Published
2019

88. Development of a self-reported version of the G8 screening tool

Author

MS Geriatrie, Circulatory Health, van Walree, Inez Charlotte, Vondeling, Ariel M., Vink, Geraldine R., van Huis-Tanja, Lieke H., Emmelot-Vonk, Marielle H., Bellera, Carine, Soubeyran, Pierre, Hamaker, Marije E., MS Geriatrie, Circulatory Health, van Walree, Inez Charlotte, Vondeling, Ariel M., Vink, Geraldine R., van Huis-Tanja, Lieke H., Emmelot-Vonk, Marielle H., Bellera, Carine, Soubeyran, Pierre, and Hamaker, Marije E.

Published
2019

89. Amerikaanse richtlijn voor geriatrische oncologie

Author

MS Geriatrie, Circulatory Health, Portielje, Johanneke E A, Hamaker, Marije E, Maas, Huub A A M, van Leeuwen, Barbara L, van den Bos, Frederiek, MS Geriatrie, Circulatory Health, Portielje, Johanneke E A, Hamaker, Marije E, Maas, Huub A A M, van Leeuwen, Barbara L, and van den Bos, Frederiek

Published
2019

90. Association of initiation of maintenance dialysis with functional status and caregiver burden

Author

Unit Opleiding Geriatrie, Unit Opleiding Aios, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Goto, Namiko A., Van Loon, Ismay N., Boereboom, Franciscus T.J., Emmelot-Vonk, Marielle H., Willems, Hanna C., Bots, Michiel L., Gamadia, Laila E., Van Bommel, Eric F.H., Van De Ven, Peter J.G., Douma, Caroline E., Vincent, Hieronymus H., Schrama, Yvonne C., Lips, Joy, Hoogeveen, Ellen K., Siezenga, Machiel A., Abrahams, Alferso C., Verhaar, Marianne C., Hamaker, Marije E., Unit Opleiding Geriatrie, Unit Opleiding Aios, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Goto, Namiko A., Van Loon, Ismay N., Boereboom, Franciscus T.J., Emmelot-Vonk, Marielle H., Willems, Hanna C., Bots, Michiel L., Gamadia, Laila E., Van Bommel, Eric F.H., Van De Ven, Peter J.G., Douma, Caroline E., Vincent, Hieronymus H., Schrama, Yvonne C., Lips, Joy, Hoogeveen, Ellen K., Siezenga, Machiel A., Abrahams, Alferso C., Verhaar, Marianne C., and Hamaker, Marije E.

Published
2019

91. The impact of colorectal surgery on health-related quality of life in older functionally dependent patients with cancer - A longitudinal follow-up study

Author

Circulatory Health, MS Geriatrie, Souwer, Esteban T D, Oerlemans, Simone, van de Poll-Franse, Lonneke V, van Erning, Felice N, van den Bos, Frederiek, Schuijtemaker, Johan S, van den Berkmortel, Franchette W P J, Ten Bokkel Huinink, Daan, Hamaker, Marije E, Dekker, Jan Willem T, Wientjes, Caroline A, Portielje, Johanna E A, Maas, Huub A A, Circulatory Health, MS Geriatrie, Souwer, Esteban T D, Oerlemans, Simone, van de Poll-Franse, Lonneke V, van Erning, Felice N, van den Bos, Frederiek, Schuijtemaker, Johan S, van den Berkmortel, Franchette W P J, Ten Bokkel Huinink, Daan, Hamaker, Marije E, Dekker, Jan Willem T, Wientjes, Caroline A, Portielje, Johanna E A, and Maas, Huub A A

Published
2019

92. Geriatric Assessment and the Relation with Mortality and Hospitalizations in Older Patients Starting Dialysis

Author

Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, van Loon, Ismay N, Goto, Namiko A, Boereboom, Franciscus T J, Bots, Michiel L, Hoogeveen, Ellen K, Gamadia, Laila, van Bommel, E F H, van de Ven, P J G, Douma, Caroline E, Vincent, H H, Schrama, Yvonne C, Lips, Joy, Siezenga, Machiel A, Abrahams, Alferso C, Verhaar, Marianne C, Hamaker, Marije E, Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, van Loon, Ismay N, Goto, Namiko A, Boereboom, Franciscus T J, Bots, Michiel L, Hoogeveen, Ellen K, Gamadia, Laila, van Bommel, E F H, van de Ven, P J G, Douma, Caroline E, Vincent, H H, Schrama, Yvonne C, Lips, Joy, Siezenga, Machiel A, Abrahams, Alferso C, Verhaar, Marianne C, and Hamaker, Marije E

Published
2019

93. Accidental falling in community-dwelling elderly with chronic kidney disease

Author

Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, Namiko A., Hamaker, Marije E., Willems, Hanna C., Verhaar, Marianne C., Emmelot-Vonk, Mariëlle H., Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, Namiko A., Hamaker, Marije E., Willems, Hanna C., Verhaar, Marianne C., and Emmelot-Vonk, Mariëlle H.

Published
2019

94. Geriatric assessment in elderly patients with end-stage kidney disease

Author

Unit Opleiding Geriatrie, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Goto, Namiko A., Van Loon, Ismay N., Morpey, Moira I., Verhaar, Marianne C., Willems, Hanna C., Emmelot-Vonk, Mariëlle H., Bots, Michiel L., Boereboom, Franciscus T.J., Hamaker, Marije E., Unit Opleiding Geriatrie, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Goto, Namiko A., Van Loon, Ismay N., Morpey, Moira I., Verhaar, Marianne C., Willems, Hanna C., Emmelot-Vonk, Mariëlle H., Bots, Michiel L., Boereboom, Franciscus T.J., and Hamaker, Marije E.

Published
2019

95. Corrigendum : A closer look at the trajectory of physical functioning in chronic hemodialysis [Age and Ageing (2017) 594-599] doi.org/10.1093/ageing/afx006

Author

Loon, Ismay Van, Hamaker, Marije E., Boereboom, Franciscus T.J., Grooteman, Muriel P.C., Blankestijn, Peter J., Van Den Dorpel, Rene M.A., Nubé, Menso J., Ter Wee, Piet M., Verhaar, Marianne C., and Bots, Michiel L.

Subjects
Ageing, Geriatrics and Gerontology
Abstract

The author would like to apologise for an error in the originally published paper. Reference 16 has been updated to appear as follows: Freak-Poli R, Kirkman M, De Castro Lima G, Direk N, Hofman A, Tiemeier H. Sexual Activity and Physical Tenderness in Older Adults: Prevalence and Associated Characteristics. Under peer review.

Published
2017

96. Geriatric Assessment and the Relation with Mortality and Hospitalizations in Older Patients Starting Dialysis

Author

van Loon, Ismay N., primary, Goto, Namiko A., additional, Boereboom, Franciscus T.J., additional, Bots, Michiel L., additional, Hoogeveen, Ellen K., additional, Gamadia, Laila, additional, van Bommel, E.F.H., additional, van de Ven, P.J.G., additional, Douma, Caroline E., additional, Vincent, H.H., additional, Schrama, Yvonne C., additional, Lips, Joy, additional, Siezenga, Machiel A., additional, Abrahams, Alferso C., additional, Verhaar, Marianne C., additional, and Hamaker, Marije E., additional

Published
2019
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97. The G8 frailty screening tool and the decision‐making process in older breast cancer patients.

Author

Scheepers, Ellen R. M., Molen, Loes F., Bos, Frederiek, Burgmans, Josephine P., Huis‐Tanja, Lieke H., and Hamaker, Marije E.

Subjects
BREAST cancer prognosis, BREAST tumor treatment, GERIATRIC assessment, BREAST tumors, CHI-squared test, STATISTICAL correlation, FRAIL elderly, MULTIVARIATE analysis, REGRESSION analysis, SURVIVAL analysis (Biometry), DECISION making in clinical medicine, PROPORTIONAL hazards models, RETROSPECTIVE studies, DATA analysis software, DESCRIPTIVE statistics, KAPLAN-Meier estimator, OLD age
Abstract

Objective: To assess the decision‐making process in fit and frail older breast cancer patients. Methods: Breast cancer patients aged ≥70 years who completed the G8 frailty screening tool (G8) were included in this retrospective study. Socio‐demographic and clinical characteristics were collected, as well as information from geriatric assessment (GA). Treatment decisions were compared with national guidelines. Results: Of 177 patients, 85 patients were considered fit by the G8 (G8‐fit) and 92 patients frail (G8‐frail). All G8‐fit and 53 G8‐frail were proposed for surgery. GA was performed in 34 patients (9 G8‐fit; 25 G8‐frail) of whom 16 (2 G8‐fit;14 G8‐frail) were considered frail (GA‐frail). 28 out of these 34 patients were considered fit for surgery (including 11 GA‐frail); their impairments were unlikely to interfere with surgery or life expectancy. Reasons for adjusting treatment were physical/cognitive condition and patient preference. Ultimately, 123 patients underwent surgery in accordance with guidelines (81 G8‐fit;42 G8‐frail, p < 0.001). Survival was reduced in G8‐frail compared to G8‐fit (p = 0.001), but G8 lost its association with mortality in multivariable survival analysis. Among patients undergoing surgery, no difference in mortality was seen between G8‐fit and G8‐frail (p = 0.996). Conclusion: The G8 is associated with treatment decisions and did not affect survival in patients undergoing surgery. In the decision‐making process, the G8 may help and estimates the need for adaptive care. [ABSTRACT FROM AUTHOR]

Published
2021
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