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58. Early ribavirin treatment of respiratory syncytial viral infection in high-risk children

Author

Groothuis, Jessie R., Woodin, Kathleen A., Katz, Robert, Robertson, Alastair D., McBride, John T., Hall, Caroline B., McWilliams, Bennie C., and Lauer, Brian A.

Subjects
Respiratory syncytial virus -- Drug therapy, Ribavirin -- Health aspects, Chronically ill children -- Care and treatment, Health
Abstract

Respiratory syncytial virus (RSV), a major cause of acute respiratory disease in children, is especially frequent among infants who have bronchopulmonary dysplasia (BPD; abnormal growth of lung tissue) or congenital heart disease (CHD) with pulmonary hypertension (high pressure in lung blood vessels). RSV is a major cause of illness and death in these children. Ribavirin is a drug that can inhibit viruses such as RSV, and has been helpful in treating children with severe RSV. The effectiveness of ribavirin during the early stages of mild RSV infections was studied in 47 children (9 female) who were at high risk due to BPD or CHD. Twenty children received ribavirin, while 27 received inert substances (placebo). Children receiving ribavirin had a significantly better medical status and had significantly better lung function, in terms of saturation of blood with oxygen. More children receiving placebo tended to have treatment failure and required intervention with ribavirin and other therapy, but this was not significant. No adverse side effects of treatment were found. The study suggests that early medical intervention, including ribavirin treatment, can reduce illness due to RSV infection in children with BPD or CHD. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

63. The use of oral acyclovir in otherwise healthy children with varicella

Author

Hall, Caroline B., Granoff, Dan M., Gromisch, Donald S., Halsey, Neal A., Kohl, Steve, Marcuse, Edgar K., Marks, Melvin I., Nankervis, George A., Pickering, Larry K., Scott, Gwendolyn B., Steele, Russell W., Yogev, Ram, Peter, Georges, Bart, Kenneth J., Broome, Claire, Hardegree, M. Carolyn, Jacobs, Richard F., MacDonald, Noni E., Orenstein, Walter A., and Rabinovich, Gina

Subjects
Acyclovir -- Health aspects, Chickenpox -- Drug therapy
Abstract

Children with varicella, or chickenpox, who are at risk for developing complications from the disease may benefit from treatment with acyclovir. Acyclovir is not recommended routinely for treatment of chickenpox in children. However, children older than 12, children with lung disorders or chronic skin infections and children whose immune systems may be dysfunctional are candidates for treatment with acyclovir. Treatment with oral acyclovir should begin within the first 24 hours of a child developing the chickenpox rash. A 1991 study found that acyclovir reduced the number of lesions when compared to a placebo, or inactive substance. Only 5% of the treated group developed new lesions by the third day of treatment compared with 20% of the placebo group. The children receiving acyclovir were treated four times each day with 20 milligrams of acyclovir per kilogram of body weight. Side effects were infrequent.

Published
1993

65. Contributors

Author

Aaskov, John, Adachi, Kristina, Aebi, Christoph, Alexander, Kenneth A., Al-Rawahi, Ghada N., Al-Zubeidi, Duha, Anjum, Seher, Ardura, Monica I., Arnon, Stephen S., Arrington, Amy, Arvin, Ann M., Atmar, Robert L., Baker, Amira, Baker, Carol J., Baltimore, Robert S., Barenkamp, Stephen J., Barnett, Elizabeth D., Barton, Theresa, Benard, Gil, Bender, Jeffrey M., Berry, Gregory J., Bhatt, Amit, Bluestone, Charles D., Blumer, Jeffrey L., Bocchini, Claire, Boyer, Kenneth M., Bradley, John S., Brasil, Patricia, Britt, William J., Bronstein, David E., Bruckner, David A., Bryant, Kristina A., Buckingham, Steven C., Byington, Carrie L., Cabada, Miguel M., Cadilla, Adriana, Campbell, Judith R., Caron, Justin E., Carrillo-Marquez, Maria, Casey, Janet R., Castagnini, Luis A., Chacko, Mariam R., Chandramohan, Lakshmi, Chapman, Louisa E., Charrel, Remi N., Chea-Woo, Elsa, Cheifetz, Ira M., Chen, Tempe K., Cherry, James D., Chinen, Javier, Ching, Natascha, Chinn, Ivan K., Christenson, John C., Coffin, Susan E., Correa, Armando G., Cox, Elaine G., Crews, Jonathan D., Cruz, Andrea T., Davidovics, Zev, Dehority, Walter N., de Lamballerie, Xavier, Dennehy, Penelope H., Doan, Minh L., Dobson, Simon R., Drutz, Jan E., Dubray, Kara A., Duppenthaler, Andrea, Dvorak, Christopher C., Edelstein, Paul H., Edwards, Kathryn M., Edwards, Morven S., El-Kamary, Samer S., Englund, Janet A., Ericson, Jessica, Fan, Leland L., Federman, Myke, Fernando, Pedro, Fischer, Philip R., Fisher, Brian T., Fisher, Randall G., Fishman, Douglas S., Flores, Anthony R., Foster, Catherine, Friedman, Ellen M., Gabaglia, Claudia Raja, Garcia, Lynne S., Gauthier, Gregory M., Gershon, Anne A., Gigliotti, Francis, Gilger, Mark A., Gillespie, Susan L., Glaser, Carol A., Goldman, David L., Goldman, Jennifer L., Goldstein, Nira A., Gonzalez, Blanca E., Green, Michael D., Groll, Andreas, Grose, Charles, Gubler, Duane J., Guevara, Javier Nieto, Hall, Caroline B., Hall, Roy A., Halstead, Scott B., Hamano, Shinjiro, Hammerschlag, Margaret R., Hannemann, Nicole L., Hanson, I. Celine, Harik, Nada, Harriman, Kathleen H., Harrison, Gail J., Healy, C. Mary, Heininger, Ulrich, Hemming-Harlo, Maria, Henderson, Sheryl L., Heresi, Gloria P., Hiatt, Peter W., Hill, Harry R., Hilmers, David C., Hoffman, Jill A., Hotez, Peter J., Howard, Leigh M., Hulten, Kristina G., Humphries, Romney M., Hunstad, David A., Hunt, W. Garrett, Huskins, W. Charles, Hyun, David Y., Jackson, Mary Anne, Jacobs, Michael R., Jacobs, Richard F., Jhaveri, Ravi, Odom, Audrey R., Johnston, Samantha H., Julapalli, Meena R., Kaplan, Sheldon L., Kearns, Gregory L., Khouri, Jessica M., Kim, Kwang Sik, Kim, Yae-Jean, King, Katherine Y., Kirchhoff, Louis V., Kleiman, Martin B., Klein, Bruce S., Kohlhoff, Stephan A., Kollmann, Tobias R., Korpe, Poonum S., Kosek, Margaret, Koster, Michael P., Krause, Peter J., Krilov, Leonard R., Krogstad, Paul, Krysan, Damian J., Kuan, Edward, Kuhls, Thomas, Labuda, Sarah M., Lantos, Paul M., La Pine, Timothy R., Heinimäki, Suvi, Larkin, Jerome M., Laurens, Matthew B., Leach, Charles T., Leber, Amy, Leggiadro, Robert J., Lehman, Deborah, Lennon, Diana R., Leung, Daniel H., Levy, Moise L., Linam, W. Matthew, Logan, Latania K., Lotze, Timothy E., Lucero, Yalda C., Lugo, Debra J., Luk, Berkley, Maloney, Susan A., Mann, Michelle C., Marquez, Lucila, Martin, Kimberly C., Mascola, Laurene, Mason, Edward O., Jr, Maspons, Aldo, Mazade, Marc A., McBride, Holly E., McCullers, Jonathan A., McIntosh, Kenneth, McJunkin, James E., McKee, Kelly T., Jr, McKinney, Ross, Jr, McNeil, J. Chase, Mejia, Rojelio, Mejias, Asuncion, Mendes Giannini, Maria José Soares, Michaels, Marian G., Michelow, Ian C., Miller, Marjorie J., Mills, James N., Mithal, Leena B., Moffett, Kathryn S., Montes, Martin, Muller, Martha, Mungwira, Randy George, Murphy, James R., Nadipuram, Santhosh M., Nataro, James P., Needham, Heather, Nielsen-Saines, Karin, Nieves, Delma J., Oberhelman, Richard, Ochoa, Theresa J., Olivero, Rosemary M., O'Ryan, Miguel, Overturf, Gary D., Palazzi, Debra L., Pannaraj, Pia S., Patel, Janak A., Paul, Mary E., Pelton, Stephen I., Pence, Morgan A., Perfect, John R., Peters, C.J., Petri, William A., Jr, Pham, Yen H., Pinheiro, Francisco P., Pinsky, Benjamin A., Pong, Alice, Porsch, Eric A., Purcell, Joan S., Quanquin, Natalie M., Quinn, Kevin K., Abdel-Rahman, Susan M., Ramilo, Octavio, Ramraj, Ramya, Revell, Paula A., Rimoin, Anne W., Romero, José R., Ross, Lawrence, Rowley, Anne H., Rupprecht, Charles E., Saez-Llorens, Xavier, Sammons, Julia Shaklee, Sánchez, Pablo, Sande, Linette, Santisteban-Ponce, Javier, Sass, Laura A., Scholand, Stephen J., Schulte, Danica J., Schuster, Jennifer E., Schutze, Gordon E., Seed, Patrick C., Serpa, Jose A., Shah, Samir S., Shapiro, Eugene D., Shapiro, Nina L., Shearer, William T., Shimizu-Cohen, Robyn, Shulman, Stanford T., Shehab, Kareem W., Shehab, Ziad M., Simos, Constantine, Smit, Michael A., Smith, P. Brian, Soni, Priya R., Sood, Sunil K., Staat, Mary Allen, Stark, Damien, Starke, Jeffrey R., Statler, Victoria A., Stechenberg, Barbara W., Steinbach, William J., St. Geme, Joseph W., III, Suen, Jeffrey, Sung, Lillian, Swanson, Douglas S., Tan, Tina Q., Taylor, Ruston S., Tolle, Michael A., Toltzis, Philip, Tomko, Stuart R., Tosi, Michael F., Tovar Padua, Leidy J., Travassos da Rosa, Amelia P.A., Tsai, Theodore F., Vahabzadeh-Hagh, Andrew M., Velarde, Jorge J., Vallejo, Jesus G., Vanchiere, John A., Venick, Robert S., Verma, Sanjay, Versalovic, James, Vesikari, Timo, Wald, Ellen R., Walsh, Thomas J., Ward, Mark A., Wattier, Rachel L., Way, Sing Sing, Weatherhead, Jill, Weinberg, Michelle, Weinberg, Nicholas, Wellington, Melanie, Welliver, Robert C., Sr, Wheeler, J. Gary, White, A. Clinton, Jr, Whitworth, Suzanne, Wiedermann, Bernhard L., Williams, John V., Williams-Bouyer, Natalie M., Woods, Charles R., Jr, Wright, Terry W., Yeganeh, Nave, Young, Edward J., Zakhour, Ramia, and Zaoutis, Theoklis

Published
2019
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66. Recognizing infection-related arthritis

Author

Lee, Lucia H. and Hall, Caroline B.

Subjects
Diagnosis, Infectious arthritis -- Diagnosis, Arthritis, Infectious -- Diagnosis
Abstract

Arthritis can be caused by a range of viruses or other infectious agents, or develop in the wake of an enteric, genitourinary, or respiratory tract infection. Knowing the possible causes [...]

Published
2000

71. Cost-effectiveness of respiratory syncytial virus prophylaxis with palivizumab

Author

Mahadevia, Parthiv J., Malinoski, Frank J., Sorbero, Melony E.S., ElHassan, Nahed O., Hall, Caroline B., Stevens,Timothy P., and Dick, Andrew W.

Subjects
Respiratory syncytial virus -- Care and treatment, Cost benefit analysis -- Evaluation, Pediatric respiratory diseases -- Care and treatment, Cost benefit analysis, Health
Published
2007

73. The Burden of Influenza in Young Children, 2004–2009

Author

Poehling, Katherine A., primary, Edwards, Kathryn M., additional, Griffin, Marie R., additional, Szilagyi, Peter G., additional, Staat, Mary A., additional, Iwane, Marika K., additional, Snively, Beverly M., additional, Suerken, Cynthia K., additional, Hall, Caroline B., additional, Weinberg, Geoffrey A., additional, Chaves, Sandra S., additional, Zhu, Yuwei, additional, McNeal, Monica M., additional, and Bridges, Carolyn B., additional

Published
2013
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74. Adherence to Guidelines for Respiratory Syncytial Virus Immunoprophylaxis Among Infants With Prematurity or Chronic Lung Disease in Three United States Counties

Author

Carroll, Kecia N., primary, Griffin, Marie R., additional, Edwards, Kathryn M., additional, Ali, Asad, additional, Zhu, Yuwei, additional, Iwane, Marika K., additional, Szilagyi, Peter G., additional, Staat, Mary A., additional, Stevens, Timothy P., additional, Hall, Caroline B., additional, Williams, John V., additional, and Hartert, Tina V., additional

Published
2012
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75. Human Coronavirus in Young Children Hospitalized for Acute Respiratory Illness and Asymptomatic Controls

Author

Prill, Mila M., primary, Iwane, Marika K., additional, Edwards, Kathryn M., additional, Williams, John V., additional, Weinberg, Geoffrey A., additional, Staat, Mary A., additional, Willby, Melisa J., additional, Talbot, H. Keipp, additional, Hall, Caroline B., additional, Szilagyi, Peter G., additional, Griffin, Marie R., additional, Curns, Aaron T., additional, and Erdman, Dean D., additional

Published
2012
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76. Chromosomally integrated human herpesvirus 6: questions and answers

Author

Pellett, Philip E., primary, Ablashi, Dharam V., additional, Ambros, Peter F., additional, Agut, Henri, additional, Caserta, Mary T., additional, Descamps, Vincent, additional, Flamand, Louis, additional, Gautheret‐Dejean, Agnès, additional, Hall, Caroline B., additional, Kamble, Rammurti T., additional, Kuehl, Uwe, additional, Lassner, Dirk, additional, Lautenschlager, Irmeli, additional, Loomis, Kristin S., additional, Luppi, Mario, additional, Lusso, Paolo, additional, Medveczky, Peter G., additional, Montoya, Jose G., additional, Mori, Yasuko, additional, Ogata, Masao, additional, Pritchett, Joshua C., additional, Rogez, Sylvie, additional, Seto, Edward, additional, Ward, Katherine N., additional, Yoshikawa, Tetsushi, additional, and Razonable, Raymund R., additional

Published
2011
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77. Immunogenicity of Trivalent Influenza Vaccine in Extremely Low-birth-weight, Premature Versus Term Infants

Author

D'Angio, Carl T., primary, Heyne, Roy J., additional, Duara, Shahnaz, additional, Holmes, Lucy C., additional, O'Shea, T. Michael, additional, Wang, Hongyue, additional, Wang, Dongwen, additional, Sánchez, Pablo J., additional, Welliver, Robert C., additional, Ryan, Rita M., additional, Schnabel, Kenneth C., additional, and Hall, Caroline B., additional

Published
2011
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82. Corrected 2007 Rotavirus Hospitalization Rates

Author

Payne, Daniel C., primary, Szilagyi, Peter G., additional, Staat, Mary Allen, additional, Edwards, Kathryn M., additional, Gentsch, Jon R., additional, Weinberg, Geoffrey A., additional, Hall, Caroline B., additional, Curns, Aaron T., additional, Clayton, Haley, additional, Griffin, Marie R., additional, Fairbrother, Gerry, additional, and Parashar, Umesh D., additional

Published
2010
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84. Secular Variation in United States Rotavirus Disease Rates and Serotypes

Author

Payne, Daniel C., primary, Szilagyi, Peter G., additional, Staat, Mary Allen, additional, Edwards, Kathryn M., additional, Gentsch, Jon R., additional, Weinberg, Geoffrey A., additional, Hall, Caroline B., additional, Curns, Aaron T., additional, Clayton, Haley, additional, Griffin, Marie R., additional, Fairbrother, Gerry, additional, and Parashar, Umesh D., additional

Published
2009
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85. Epidemiology and laboratory diagnosis of infection with viral and bacterial pathogens in infants hospitalized for suspected sepsis

Author

Dagan, Ron, Hall, Caroline B., Powell, Keith R., and Menegus, Marilyn A.

Subjects
Virus diseases in children -- Diagnosis, Influenza -- Diagnosis, Bacteria, Pathogenic -- Diagnosis, Enteroviruses -- Diagnosis, Infants (Newborn) -- Hospital care, Health
Abstract

A study was conducted among 233 previously healthy infants less than three months of age to determine the frequency and distribution of bacteria and viruses in infants hospitalized with suspected sepsis. Among the 157 infants proven to be suffering from a viral infection, virus was detected in 33 percent of 138 infected infants within 24 hours, and in 64 percent within 72 hours. Acute illness in infants less than three months of age raises the question of serious bacterial infection. Very few infants hospitalized for suspected bacterial infections actually suffer from bacteremia (bacteria in the blood). Those who do not have bacterial infection are often thought to have a viral infection. In a study, the most common viruses responsible for these acute infections were respiratory syncytial virus (RSV), affecting striated muscle fibers, and influenza virus A during the winter and enteroviruses, affecting the gastrointestinal tract, during the summer and fall. The detection of virus does not rule out bacterial infections. Therefore, after cessation of antibiotic therapy is considered for an infant with virus-positive culture or test results, the clinical picture as well as the infant's general condition must be taken into consideration.

Published
1989

86. Influenza in children with cancer

Author

Kempe, Allison, Hall, Caroline B., MacDonald, Noni E., Foye, Howard R., Woodin, Kathleen A., Cohen, Harvey J., Lewis, Edward D., Gullace, Michelle, Gala, Christine L., and Dulberg, Corinne S.

Subjects
Influenza vaccines -- Evaluation, Cancer in children -- Complications, Vaccination of children -- Dosage and administration, Immunization -- Case studies, Cancer -- Physiological aspects, Chemotherapy -- Complications, Health
Abstract

The American Academy of Pediatrics recommends yearly immunization for children at risk for the influenza virus infection. A study was done over two influenza seasons of 73 patients under 19 years of age with any type of cancer who had been receiving chemotherapy. Children with cancer are two times more likely to get the virus, and they have longer infection periods. These children are forced to stop any chemotherapy treatments and may need extensive medical attention as a result of the infection. Vaccine schedules and doses for the normal population may not apply to children with cancer. Of the immunized children with cancer, 33 percent were infected with the virus, compared with 14 percent of their healthy siblings or matched community controls. The amount of the vaccine considered protective for the noncancerous subjects was unable to prevent the disease in 24 percent of the children with cancer. The normal recommended dose of influenza vaccine is not effective in children with cancer and should be adjusted to meet their needs.

Published
1989

87. Fighting viral infections: a survey of new agents

Author

Hall, Caroline B., Knight, Vernon, Mostow, Steven R., and Lamb, Carolyn

Subjects
Care and treatment, Innovations, Dosage and administration, Viral research -- Innovations, Antiviral agents -- Dosage and administration -- Innovations, Influenza -- Care and treatment, Virus diseases -- Care and treatment, Virus research -- Innovations
Abstract

Fighting viral infections: A survey of new agents The only available drug for the prophylaxis and treatment of influenza A is amantadine HCl (Symmetrel). While the first defense against influenza [...]

Published
1986

100. Communitywide Laboratory-Based Influenza Surveillance Focused On Older Persons, 1989–1992

Author

Barker, William H., primary, Menegus, Marilyn A., additional, Hall, Caroline B., additional, Betts, Robert F., additional, Freundlich, Charlene B., additional, Long, Christine E., additional, O'Brien, Diane H., additional, Weiner, Leonard B., additional, Cunningham, Coleen, additional, Bonville, Cynthia A., additional, Alger, Kathleen P., additional, and Waltz, Edward C., additional

Published
1995
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