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334 results on '"Habermehl, D"'

51. The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Author

Klement, R. J., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., Andratschke, N., Klement, R. J., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., and Andratschke, N.

Published
2017

52. Patterns of care and outcome analysis of SBRT for colorectal lung and liver metastases in 388 patients with 500 metastases: an analysis of the DEGRO working group Stereotactic Radiotherapy

Author

Basler, L., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Klement, R. J., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., Andratschke, N., Basler, L., Adebahr, S., Alheit, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Heggemann, J., Brunner, T., Duma, M., Eble, M. J., Ernst, I, Gerum, S., Habermehl, D., Hass, P., Henkenberens, C., Hildebrandt, G., Imhoff, D., Kahl, H., Klass, N. D., Klement, R. J., Krempien, R., Lewitzki, V, Lohaus, F., Ostheimer, C., Petersen, C., Papachristofilou, A., Rieber, J., Schneider, T., Schrade, E., Semrau, R., Teichgraeber, U., Wachter, S., Wittig, A., Guckenberger, M., and Andratschke, N.

Published
2017

55. Optimization of carbon ion treatment plans by integrating tissue specific α/β-values for patients with non-resectable pancreatic cancer

Author

Dreher, C., Scholz, C., Pommer, M., Brons, S., Prokesch, H., Ecker, S., Debus, J., Jäkel, O., Combs, S.E., and Habermehl, D.

Abstract

Background: The aim of the thesis is to improve treatment plans of carbon ion irradiation by integrating the tissues' specific α/β-values for patients with locally advanced pancreatic cancer (LAPC). Material and Methods: Five patients with LAPC were included in this study. By the use of the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) treatment plans with carbon ion beams have been created. Dose calculation was based on α/β-values for both organs at risk (OAR) and the tumor. Twenty-five treatment plans and thirty-five forward calculations were created. With reference to the anatomy five field configurations were included. Single Beam Optimization (SBO) and Intensity Modulated Particle Therapy (IMPT) were used for optimization. The plans were analyzed with respect to both dose distributions and individual anatomy. The plans were evaluated using a customized index. Results: With regard to the target, a field setup with one single posterior field achieves the highest score in our index. Field setups made up of three fields achieve good results in OAR sparing. Nevertheless, the field setup with one field is superior in complex topographic conditions. But, allocating an α/β-value of 2 Gy to the spinal cord leads to critical high maximum doses in the spinal cord. The evaluation of dose profiles showed significant dose peaks at borders of the α/β-gradient, especially in case of a single posterior field. Conclusion: Optimization with specific α/β-values allows a more accurate view on dose distribution than previously. A field setup with one single posterior field achieves good results in case of difficult topographic conditions, but leads to high maximum doses to the spinal cord. So, field setups with multiple fields seem to be more adequate in case of LAPC, being surrounded by highly radiosensitive normal tissues.

Published
2016

56. Defining the role of palliative radiotherapy in bone metastasis from primary liver cancer: An analysis of survival and treatment efficacy

Author

Habermehl, D., Haase, K., Rieken, S., Debus, J., and Stephanie Combs

Subjects
Adult, Male, Cancer Research, Carcinoma, Hepatocellular, Bone Neoplasms, Hepatic Duct, Common, Kaplan-Meier Estimate, Medical Records, 030218 nuclear medicine & medical imaging, Cholangiocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, Liver Neoplasms, Palliative Care, General Medicine, Middle Aged, Prognosis, Treatment Outcome, Bile Duct Neoplasms, Oncology, 030220 oncology & carcinogenesis, Female, Dose Fractionation, Radiation, Klatskin Tumor
Abstract

Aims and background Primary liver cancer is the fourth leading cause of cancer-related death worldwide and is still associated with a poor prognosis. Hepatocellular carcinoma and cholangiocarcinoma are known to cause bone metastasis resulting in pain, neurologic impairment and risk of fracture. Palliative radiotherapy is the treatment of choice in symptomatic bone lesions and is usually performed as percutaneous fractionated radiotherapy. Methods and study design From June 1987 to December 2009, 41 patients (median age, 64 years) with bone metastasis received radiotherapy in our department. The analyzed patients were treated for 67 sites of bone lesions. We analyzed the applied fractionation schedules and the preferred sites of metastasis and symptoms, evaluated the therapeutic outcome in terms of symptomatic improvement, and described the prognosis of these patients. Results Main indication for palliative radiotherapy was pain in 94% of all cases. Most frequent radiation protocols were 10 × 3 Gy (20 patients) and 20 × 2 Gy (19 patients). Median applied overall dose was 39 Gy (range, 4–48 Gy) and median single dose was 2.5 Gy (range, 1.8–4 Gy). The median duration of the radiotherapeutic treatment was 15 days (range, 2–24 days) and in 12 cases treatment was discontinuated. The overall response rate to palliative radiotherapy in bone metastasis was 77%. Median overall survival in both cholangiocarcinoma and hepatocellular carcinoma patients was 4.2 months after initiation of radiotherapy (range, 0.2–38.9). Conclusions Considering the poor prognosis of patients with bone metastasis in hepatocellular carcinoma and cholangiocarcinoma, with a poor median survival of 3.7–5.0 months according to our study and existing literature, shorter radiotherapy schedules or even single-fraction irradiation can be considered.

Published
2011

59. OC-0523: SBRT for oligo-metastatic liver disease–effect of chemotherapy and histology on local tumor control

Author

Klement, R., primary, Guckenberger, M., additional, Alheid, H., additional, Allgaeuer, M., additional, Becker, G., additional, Blanck, O., additional, Boda-Hegemann, J., additional, Brunner, T., additional, Duma, M., additional, Gerum, S., additional, Habermehl, D., additional, Hildebrandt, G., additional, Lewitzki, V., additional, Ostheimer, C., additional, Papachristofilou, A., additional, Petersen, C., additional, Schneider, T., additional, Semrau, R., additional, Wachter, S., additional, and Andratschke, N., additional

Published
2017
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63. Patterns of care and outcome analysis of SBRT for liver metastases - a DEGRO database initiative

Author

Andratschke, N., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Hegemann, J., Brunner, T., Combs, S., Duma, M., Gerum, S., Guckenberger, M., Hildebrandt, G., Ostheimer, C., Panje, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., Habermehl, D., Andratschke, N., Alheid, H., Allgaeuer, M., Becker, G., Blanck, O., Boda-Hegemann, J., Brunner, T., Combs, S., Duma, M., Gerum, S., Guckenberger, M., Hildebrandt, G., Ostheimer, C., Panje, C., Papachristofilou, A., Petersen, C., Schneider, T., Semrau, R., Wachter, S., and Habermehl, D.

Published
2016

64. OC-0445: Patterns of care and outcome analysis of SBRT for liver metastases - a DEGRO database initiative

Author

Andratschke, N., primary, Alheid, H., additional, Allgäuer, M., additional, Becker, G., additional, Blanck, O., additional, Boda-Hegemann, J., additional, Brunner, T., additional, Combs, S., additional, Duma, M., additional, Gerum, S., additional, Guckenberger, M., additional, Hildebrandt, G., additional, Ostheimer, C., additional, Panje, C., additional, Papachristofilou, A., additional, Petersen, C., additional, Schneider, T., additional, Semrau, R., additional, Wachter, S., additional, and Habermehl, D., additional

Published
2016
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65. MRT-basierte Hochpräzisionsstrahlentherapie im orthotopen Pankreastumor-Mausmodell : Eine Bestrahlungsplanungsstudie.

Author

Dobiasch, S., Kampfer, S., Habermehl, D., Duma, M. N., Felix, K., Strauss, A., Schilling, D., Wilkens, J. J., and Combs, S. E.

Subjects
ANIMAL experimentation, CELL lines, COMPUTED tomography, MAGNETIC resonance imaging, COMPUTERS in medicine, MEDICAL research, MICE, PANCREATIC tumors, RADIOTHERAPY, RESEARCH funding, TUMORS
Abstract

Background and Purpose: Recently, imaging and high-precision irradiation devices for preclinical tumor models have been developed. Image-guided radiation therapy (IGRT) including innovative treatment planning techniques comparable to patient treatment can be achieved in a translational context. The study aims to evaluate magnetic resonance imaging/computed tomography (MRI/CT)-based treatment planning with different treatment techniques for high-precision radiation therapy (RT).Materials and Methods: In an orthotopic pancreatic cancer model, MRI/CT-based radiation treatment planning was established. Three irradiation techniques (rotational, 3D multifield, stereotactic) were performed with the SARRP system (Small Animal Radiation Research Platform, Xstrahl Ltd., Camberley, UK). Dose distributions in gross tumor volume (GTV) and organs at risk (OAR) were analyzed for each treatment setting.Results: MRI with high soft tissue contrast improved imaging of GTV and OARs. Therefore MRI-based treatment planning enables precise contouring of GTV and OARs, thus, providing a perfect basis for an improved dose distribution and coverage of the GTV for all advanced radiation techniques.Conclusion: An MRI/CT-based treatment planning for high-precision IGRT using different techniques was established in an orthotopic pancreatic tumor model. Advanced radiation techniques allow considering perfect coverage of GTV and sparing of OARs in the preclinical setting and reflect clinical treatment plans of pancreatic cancer patients. [ABSTRACT FROM AUTHOR]

Published
2018
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66. Strahlentherapie bei Weichteilsarkomen der Extremitäten.

Author

Habermehl, D.

Abstract

Hintergrund: Die funktionserhaltende Behandlung von Patienten mit Weichteilsarkomen (WTS) der Extremitäten ist eine interdisziplinäre Herausforderung.Fragestellung: Es erfolgte eine Analyse der Evidenzlage zu Stellenwert und Art der radiotherapeutischen Behandlung (RT) innerhalb multimodaler Konzepte.Material und Methode: Es erfolgten die Zusammenstellung aktueller Leitlinien zur multimodalen Behandlung, insbesondere zur Rolle der prä- oder postoperativen RT bei WTS der Extremitäten sowie Darstellung und Erläuterung der Rolle moderner strahlentherapeutischer Spezialtechniken.Ergebnisse: Sowohl die prä- als auch die postoperative RT sind empfohlene Indikationen bei WTS-Patienten in den Stadien II und III. Eine klare Empfehlung gibt es auch für die postoperative RT bei inkompletter Resektion. Der Einsatz sowohl der prä- als auch der postoperativen RT korreliert mit einer Verbesserung der lokalen Kontrolle, ein positiver Einfluss auf das Überleben bleibt am ehesten auf die Subgruppe mit High-grade-WTS beschränkt. Langfristig zeigt die präoperative RT weniger Spättoxizitäten, führt jedoch akut zu mehr Wundkomplikationen. Moderne Spezialtechniken wie die bildgeführte intensitätsmodulierte Radiotherapie (IG-IMRT), die intraoperative Radiotherapie (IORT) und die Brachytherapie (BT) können die Nebenwirkungen deutlich reduzieren.Schlussfolgerungen: Moderne strahlentherapeutische Techniken führen zu einer verbesserten lokalen Kontrolle bei Patienten mit WTS in den Stadien II und III [ABSTRACT FROM AUTHOR]

Published
2018
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68. Extra Cranial stereotactical Radiotherapy (ESRT) with primary and secondary Liver Tumors-first Results with > 650 Patients of the DEGRO AG Stereotaxy

Author

Ernst, I, Andratschke, N., Brunner, T., Blanck, O., Habermehl, D., Papachristofilou, A., Allgaeuer, M., Gauer, T., Petersen, C., Wachter, S., Semrau, R., Kornhuber, C., Ostheimer, C., Gerum, S., Seegenschmiedt, H., Schneider, T., Lubinski-de Lange, G., Alheit, H., Moustakis, C., Guckenberger, M., Ernst, I, Andratschke, N., Brunner, T., Blanck, O., Habermehl, D., Papachristofilou, A., Allgaeuer, M., Gauer, T., Petersen, C., Wachter, S., Semrau, R., Kornhuber, C., Ostheimer, C., Gerum, S., Seegenschmiedt, H., Schneider, T., Lubinski-de Lange, G., Alheit, H., Moustakis, C., and Guckenberger, M.

Published
2014

69. Der Einfluss einer Radio-Chemotherapie auf immuntherapeutisch relevante Zellen

Author

Schuler, P, Sorg, R, Börger, V, Habermehl, D, Bölke, E, Greve, J, Schipper, J, and Hoffmann, TK

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

In Vorbereitung auf eine geplante Radio-Chemo-Immuntherapie für Patienten mit fortgeschrittenen Plattenepithelkarzinomen des Kopf-Hals-Bereichs wurde in der vorliegenden Studie der Einfluss einer Radio-Chemotherapie (RCT – perkutan bis 64 Gy, 5-FU + Mitomycin / Cisplatin) auf immuntherapeutisch[for full text, please go to the a.m. URL], 80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie

Published
2009
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70. ein Tübinger Ansatz

Author

Habermehl, D, Kowalski, A, Zrenner, C, Schrauth, M, and Zipfel, S

Subjects
ddc: 610
Published
2007

73. Dendritic cell generation and CD4+CD25HIGHFOXP3+ Regulatory T cells in human head and neck carcinoma during Radio-chemotherapy

Author

Schuler, PJ, Börger, V, Bölke, E, Habermehl, D, Matuschek, C, Wild, CA, Greve, J, Bas, M, Schilling, B, Bergmann, C, Trellakis, S, Budach, W, Gauler, T, Brandau, S, Lang, S, Whiteside, TL, Sorg, RV, Hoffmann, TK, Schuler, PJ, Börger, V, Bölke, E, Habermehl, D, Matuschek, C, Wild, CA, Greve, J, Bas, M, Schilling, B, Bergmann, C, Trellakis, S, Budach, W, Gauler, T, Brandau, S, Lang, S, Whiteside, TL, Sorg, RV, and Hoffmann, TK

Published
2011

74. Diagnostik und Therapie des hepatozellulären Karzinoms

Author

Greten, T., additional, Malek, N., additional, Schmidt, S., additional, Arends, J., additional, Bartenstein, P., additional, Bechstein, W., additional, Bernatik, T., additional, Bitzer, M., additional, Chavan, A., additional, Dollinger, M., additional, Domagk, D., additional, Drognitz, O., additional, Düx, M., additional, Farkas, S., additional, Folprecht, G., additional, Galle, P., additional, Geißler, M., additional, Gerken, G., additional, Habermehl, D., additional, Helmberger, T., additional, Herfarth, K., additional, Hoffmann, R., additional, Holtmann, M., additional, Huppert, P., additional, Jakobs, T., additional, Keller, M., additional, Klempnauer, J., additional, Kolligs, F., additional, Körber, J., additional, Lang, H., additional, Lehner, F., additional, Lordick, F., additional, Lubienski, A., additional, Manns, M., additional, Mahnken, A., additional, Möhler, M., additional, Mönch, C., additional, Neuhaus, P., additional, Niederau, C., additional, Ocker, M., additional, Otto, G., additional, Pereira, P., additional, Pott, G., additional, Riemer, J., additional, Ringe, K., additional, Ritterbusch, U., additional, Rummeny, E., additional, Schirmacher, P., additional, Schlitt, H., additional, Schlottmann, K., additional, Schmitz, V., additional, Schuler, A., additional, Schulze-Bergkamen, H., additional, von Schweinitz, D., additional, Seehofer, D., additional, Sitter, H., additional, Straßburg, C., additional, Stroszczynski, C., additional, Strobel, D., additional, Tannapfel, A., additional, Trojan, J., additional, van Thiel, I., additional, Vogel, A., additional, Wacker, F., additional, Wedemeyer, H., additional, Wege, H., additional, Weinmann, A., additional, Wittekind, C., additional, Wörmann, B., additional, and Zech, C., additional

Published
2013
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80. 258 HYPOFRACTIONATED CARBON ION THERAPY DELIVERED WITH SCANNED ION BEAMS FOR PATIENTS WITH HEPATOCELLULAR CARCINOMA – FEASIBILITY AND CLINICAL RESPONSE

Author

Habermehl, D., primary, Debus, J., additional, Ganten, T., additional, Ganten, M.-K., additional, Bauer, J., additional, Brecht, I.C., additional, Stephan, B., additional, Haberer, T., additional, Härtig, M., additional, Jäkel, O., additional, Parodi, K., additional, Welzel, T., additional, and Combs, S.E., additional

Published
2013
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81. Hypofractionated Carbon Ion Therapy delivered with Scanned Ion Beams for Patients with Hepatocellular Carcinoma – Feasibility and Clinical Response

Author

Habermehl, D, primary, Debus, J, additional, Ganten, T, additional, Ganten, MK, additional, Haertig, M, additional, Brons, S, additional, Brecht, IC, additional, Herfarth, KK, additional, Bauer, J, additional, Parodi, K, additional, Jäkel, O, additional, Haberer, T, additional, and Combs, SE, additional

Published
2013
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92. Cover

Author

Habermehl, Diederick

Published
2013

95. Preface

Author

Habermehl, Diederick

Published
2013

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