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596 results on '"Gutiérrez, Norma C."'

54. Mexico : passage of NAFTA

Author

Gutiérrez, Norma C.

Subjects
North American Free Trade Agreement (1992 December 17)
Published
1997

55. Mexican duty-free laws.

Author

Gutiérrez, Norma C.

Subjects
Customs privileges -- Mexico., Duty-free importation -- Law and legislation -- Mexico.
Published
1997

65. Adoption in Guatemala

Author

Gutiérrez, Norma C.

Subjects
Adoption -- Law and legislation -- Guatemala., Adoption -- Law and legislation.
Published
1994

67. U.S. citizens and Mexican criminal law

Author

Gutiérrez, Norma C.

Subjects
Criminal law -- Mexico., Americans -- Legal status, laws, etc. -- Mexico., Americans -- Mexico.
Published
1994

68. Marriage between an uncle and a niece in Mexico

Author

Gutiérrez, Norma C.

Subjects
Domestic relations -- Mexico., Incest -- Law and legislation -- Mexico., Marriage law -- Mexico., Domestic relations., Incest -- Law and legislation.
Published
1994

70. Mexico: casino gambling

Author

Gutiérrez, Norma C.

Subjects
Casinos -- Mexico., Gambling -- Mexico., Casinos., Gambling.
Published
1994

73. Baby-selling in Costa Rica

Author

Gutiérrez, Norma C.

Subjects
Child trafficking -- Law and legislation -- Costa Rica.
Published
1993

81. Foreign internships in Mexico

Author

Gutiérrez, Norma C.

Subjects
Internship programs -- Mexico., Labor laws and legislation -- Mexico.
Published
1992

83. Mexico : mining law

Author

Gutiérrez, Norma C.

Subjects
Mining law -- Mexico.
Published
1992

85. Parentage in Honduras.

Author

Gutiérrez, Norma C.

Subjects
Children -- Legal status, laws, etc. -- Honduras., Illegitimacy -- Honduras.
Published
1992

86. NAFTA's debate in the Mexican Senate

Author

Gutiérrez, Norma C.

Subjects
North American Free Trade Agreement (1992 December 17), Legislative bodies -- Freedom of debate. -- Mexico, Treaties.
Published
1992

92. Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma

Author

Goicoechea, Ibai, Puig, Noemi, Cedena, Maria-Teresa, Burgos, Leire, Cordón, Lourdes, Vidriales, María-Belén, Flores-Montero, Juan, Gutierrez, Norma C., Calasanz, Maria-Jose, Ramos, Maria-Luisa Martin, Lara-Astiaso, David, Vilas-Zornoza, Amaia, Alignani, Diego, Rodriguez, Idoia, Sarvide, Sarai, Alameda, Daniel, Garcés, Juan José, Rodriguez, Sara, Fresquet, Vicente, Celay, Jon, Garcia-Sanz, Ramón, Martinez-Lopez, Joaquin, Oriol, Albert, Rios, Rafael, Martin-Sanchez, Jesus, Martinez-Martinez, Rafael, Sarra, Josep, Hernandez, Miguel-Teodoro, de la Rubia, Javier, Krsnik, Isabel, Moraleda, Jose-Maria, Palomera, Luis, Bargay, Joan, Martinez-Climent, Jose-Angel, Orfao, Alberto, Rosiñol, Laura, Mateos, Maria-Victoria, Lahuerta, Juan-José, Blade, Joan, San Miguel, Jesús, and Paiva, Bruno

Published
2021
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93. Molecular Characterization of Chronic Lymphocytic Leukemia Patients with a High Number of Losses in 13q14

Author

Rodríguez, Ana Eugenia, Hernández, Jose Ángel, Benito, Rocío, Gutiérrez, Norma C., García, Juan Luis, Hernández Sánchez, María, Risueño, Alberto, Sarasquete, M. Eugenia, Fermiñán, Encarna, Fisac, Rosa, García de Coca, Alfonso, Martín-Núñez, Guillermo, Heras, Natalia de las, Recio, Isabel, Gutiérrez, Oliver, Rivas, Javier De Las, González, Marcos, Hernández-Rivas, Jesús M., Rodríguez, Ana Eugenia, Hernández, Jose Ángel, Benito, Rocío, Gutiérrez, Norma C., García, Juan Luis, Hernández Sánchez, María, Risueño, Alberto, Sarasquete, M. Eugenia, Fermiñán, Encarna, Fisac, Rosa, García de Coca, Alfonso, Martín-Núñez, Guillermo, Heras, Natalia de las, Recio, Isabel, Gutiérrez, Oliver, Rivas, Javier De Las, González, Marcos, and Hernández-Rivas, Jesús M.

Abstract

Background Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy donors. Results Chronic lymphocytic leukemia patients with higher percentages of 13q- cells (>80%) showed a different level of gene expression as compared to patients with lower percentages (<80%, 13q-L). This deregulation affected genes involved in apoptosis and proliferation (BCR and NFkB signaling), leading to increased proliferation and decreased apoptosis in 13q-H patients. Deregulation of several microRNAs, such as miR-15a, miR-155, miR-29a and miR-223, was also observed in these patients. In addition, our study also suggests that the gene expression pattern of 13q-H cases could be similar to the patients with 11q- or 17p-. Conclusions This study provides new evidence regarding the heterogeneity of 13q deletion in chronic lymphocytic leukemia patients, showing that apoptosis, proliferation as well as miRNA regulation are involved in cases with higher percentages of 13q- cells., Spanish Fondo de Investigaciones Sanitarias, Caja de Burgos-Banca Cívica, Gerencia Regional de Salud de Castilla y León, Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation, Cancer Research Foundation of Salamanca University, Redes de Investigación, Depto. de Bioquímica y Biología Molecular, Fac. de Farmacia, TRUE, pub

Published
2024

94. Curative Strategy for High-Risk Smoldering Myeloma: Carfilzomib, Lenalidomide, and Dexamethasone (KRd) Followed by Transplant, KRd Consolidation, and Rd Maintenance.

Author

Mateos, María-Victoria, Martínez-López, Joaquin, Rodriguez Otero, Paula, González-Calle, Verónica, Gonzalez, Marta Sonia, Oriol, Albert, Gutiérrez, Norma C., Ríos-Tamayo, Rafael, Rosiñol, Laura, Alvarez Rivas, Miguel Angel, Bargay, Joan, Gonzalez-Rodriguez, Ana Pilar, Alegre, Adrián, Escalante, Fernando, Iñigo Rodríguez, María Belén, De La Rubia, Javier, Teruel, Ana Isabel, de Arriba, Felipe, Palomera, Luis, and Hernández, Miguel T.

Published
2024
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95. Liquid biopsy for molecular characterization of diffuse large B‐cell lymphoma and early assessment of minimal residual disease.

Author

Alcoceba, Miguel, Stewart, James P., García‐Álvarez, María, Díaz, Luis G., Jiménez, Cristina, Medina, Alejandro, Chillón, M. Carmen, Gazdova, Jana, Blanco, Oscar, Díaz, Francisco J., Peñarrubia, María J., Fernández, Silvia, Montes, Carlos, Cabero, Almudena, Caballero, María D., García‐Sanz, Ramón, González, Marcos, González, David, Tamayo, Pilar, and Gutiérrez, Norma C.

Subjects
DIFFUSE large B-cell lymphomas, POSITRON emission tomography computed tomography
Abstract

Summary: Circulating tumour DNA (ctDNA) allows genotyping and minimal residual disease (MRD) detection in lymphomas. Using a next‐generation sequencing (NGS) approach (EuroClonality‐NDC), we evaluated the clinical and prognostic value of ctDNA in a series of R‐CHOP‐treated diffuse large B‐cell lymphoma (DLBCL) patients at baseline (n = 68) and after two cycles (n = 59), monitored by metabolic imaging (positron emission tomography combined with computed tomography [PET/CT]). A molecular marker was identified in 61/68 (90%) ctDNA samples at diagnosis. Pretreatment high ctDNA levels significantly correlated with elevated lactate dehydrogenase, advanced stage, high‐risk International Prognostic Index and a trend to shorter 2‐year progression‐free survival (PFS). Valuable NGS data after two cycles of treatment were obtained in 44 cases, and 38 achieved major molecular response (MMR; 2.5‐log drop in ctDNA). PFS curves displayed statistically significant differences among those achieving MMR versus those not achieving MMR (2‐year PFS of 76% vs. 0%, p < 0.001). Similarly, more than 66% reduction in ΔSUVmax by PET/CT identified two subgroups with different prognosis (2‐year PFS of 83% vs. 38%; p < 0.001). Combining both approaches MMR and ΔSUVmax reduction, a better stratification was observed (2‐year PFS of 84% vs. 17% vs. 0%, p < 0.001). EuroClonality‐NDC panel allows the detection of a molecular marker in the ctDNA in 90% of DLBCL. ctDNA reduction at two cycles and its combination with interim PET results improve patient prognosis stratification. [ABSTRACT FROM AUTHOR]

Published
2024
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97. Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma

Author

Maia, Catarina, Puig, Noemi, Cedena, Maria-Teresa, Goicoechea, Ibai, Valdes-Mas, Rafael, Vazquez, Iria, Chillon, Maria-Carmen, Aguirre, Paula, Sarvide, Sarai, Gracia-Aznárez, Francisco Javier, Alkorta, Gorka, Calasanz, Maria-Jose, Garcia-Sanz, Ramon, Gonzalez, Marcos, Gutierrez, Norma C., Martinez-Lopez, Joaquin, Perez, José J., Merino, Juana, Moreno, Cristina, Burgos, Leire, Alignani, Diego, Botta, Cirino, Prosper, Felipe, Matarraz, Sergio, Orfao, Alberto, Oriol, Albert, Teruel, Ana-Isabel, de Paz, Raquel, de Arriba, Felipe, Hernandez, Miguel T., Palomera, Luis, Martinez, Rafael, Rosiñol, Laura, Mateos, Maria-Victoria, Lahuerta, Juan-Jose, Blade, Joan, San Miguel, Jesus F., and Paiva, Bruno

Published
2020
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98. A New Next-Generation Sequencing Strategy for the Simultaneous Analysis of Mutations and Chromosomal Rearrangements at DNA Level in Acute Myeloid Leukemia Patients

Author

Prieto-Conde, M. Isabel, Corchete, Luis A., García-Álvarez, María, Jiménez, Cristina, Medina, Alejandro, Balanzategui, Ana, Hernández-Ruano, Montserrat, Maldonado, Rebeca, Sarasquete, M. Eugenia, Alcoceba, Miguel, Puig, Noemí, González-Calle, Verónica, García-Sanz, Ramón, Gutiérrez, Norma C., González-Díaz, Marcos, and Chillón, M. Carmen

Published
2020
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