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Anomaly detection of sequences is a hot topic in data mining. Anomaly Detection using Piecewise Aggregate approximation in the Amplitude Domain (called ADPAAD) is one of the widely used methods in anomaly detection of sequences. The core step in the classical algorithm for performing ADPAAD is to construct an approximate representation of the subsequence, where the elements of each subsequence are divided into several subsections according to the amplitude domain and then the average of the subsections is computed. It is computationally expensive when processing large-scale sequences. In this paper, we propose a quantum algorithm for ADPAAD, which can divide the subsequence elements and compute the average in parallel. Our quantum algorithm can achieve polynomial speedups on the number of subsequences and the length of subsequences over its classical counterpart.

Nonlinear stiffening is a ubiquitous property of major types of biopolymers that make up the extracellular matrices (ECM) including collagen, fibrin and basement membrane. Within the ECM, many types of cells such as fibroblasts and cancer cells are known to mechanically stretch their surroundings that locally stiffens the matrix. Although the bulk nonlinear elastic behaviors of these biopolymer networks are well studied, their local mechanical responses remain poorly characterized. Here, to understand how a living cell feels the nonlinear mechanical resistance from the ECM, we mimic the cell-applied local force using optical tweezers; we report that the local stiffening responses in highly nonlinear ECM are significantly weaker than responses found in bulk rheology, across two orders of magnitude of the locally applied force since the onset of stiffening. With a minimal model, we show that a local point force application can induce a stiffened region in the matrix, which expands with increasing magnitude of the point force. Furthermore, we show that this stiffened region behaves as an effective probe upon local loading. The local nonlinear elastic response can be attributed to the nonlinear growth of this effective probe that linearly deforms an increasing portion of the matrix.

In a diversity of physiological contexts, eukaryotic cells adhere to an extracellular matrix (ECM), a disordered network with complex nonlinear mechanics. Such cells can perform mechanosensation: using local force probing they can measure and respond to their substrate's mechanical properties. It remains unclear, however, how the mechanical complexity of the ECM at the cellular scale impacts mechanosensation. Here, we investigate the physical limits of mechanosensation imposed by the inherent structural disorder and nonlinear elastic response of the ECM. Using a theoretical framework for disordered fiber networks, we find that the extreme mechanical heterogeneity that cells can locally sense with small probing forces is strongly reduced with increasing force. Specifically, we predict that the accuracy of mechanosensation dramatically improves with force, following a universal power law insensitive to constitutive details, which we quantitatively confirm using microrheology experiments in collagen and fibrin gels. We provide conceptual insights into this behavior by introducing a general model for nonlinear mechanosensation, based on the idea of an emergent nonlinear length-scale associated with fiber buckling. This force-dependent length-scale enhances the range over which local mechanical measurements are performed, thereby averaging the response of a disordered network over an enlarged region. We show with an example how a cell can use this nonlinear mechanosensation to infer the macroscopic mechanical properties of a disordered ECM using local measurements. Together, our results demonstrate that cells can take advantage of the inherent nonlinearity of fibrous networks to robustly sense, control, and respond to their mechanical environment.

Sea lice are a threat to the health of both wild and farmed salmon and an economic burden for salmon farms. With a free living larval stage, sea lice can disperse tens of kilometers in the ocean between salmon farms, leading to connected sea lice populations that are difficult to control in isolation. In this paper we develop a simple analytical model for the dispersal of sea lice between two salmon farms. From the model we calculate the arrival time distribution of sea lice dispersing between farms, as well as the level of cross-infection of sea lice. We also use numerical flows from a hydrodynamic model, coupled with a particle tracking model, to directly calculate the arrival time of sea lice dispersing between two farms in the Broughton Archipelago, BC, in order to fit our analytical model and find realistic parameter estimates. Using the parametrized analytical model we show that there is often an intermediate inter-farm spacing that maximizes the level of cross infection between farms, and that increased temperatures will lead to increased levels of cross infection., Comment: 32 pages, 5 figures

Many researches from both the theoretical and experimental sides have been performed to search for a new Higgs Boson lighter than the 125 $GeV$ Higgs boson which was discovered at the LHC in 2012. In this paper we explore the possibility of constraining a lighter neutral custodial fiveplet scalar $H_{5}^{0}$ in the Georgi-Machacek (GM) model by the latest results of the search for a lighter Higgs boson decaying into two photons from LHC data. The custodial-singlet mass eigenstate $h$ or $H$ is considered to be the LHC observed 125 $GeV$ Higgs boson. A new set of constrained parameters that is favoured by low-mass $H_{5}^{0}$, is proposed to generate events efficiently. The production of $H_{5}^{0}$ from the scan based on the constrained parameters is compared to the latest results of the search for a lighter Higgs boson decaying into two photons by CMS Collaboration, after the theoretical constraints from GM model and the constraints from all existing relevant experimental measurements including the recent results of the Higgs boson searches from the LHC. The numerical analyses of the surviving GM parameter space are performed. The tendencies and correlations of the GM input parameters from the phenomenological studies are summarized. In addition the discovery potential of other interesting decay channels of this low-mass neutral custodial fiveplet scalar are discussed., Comment: 8 pages, 5 figures, submitted to Chinese Physics C

Rapid and direct monitoring of dissolved gases in liquids under strong electromagnetic interference is very important. Electronic gas sensors that can be placed into liquids are difficult to work reliably under strong electromagnetic fields. The existing optical monitoring techniques for dissolved gases all require gas-liquid separation, and are conducted in gas phase, which have poor timeliness. In this paper, a dissolved gas monitoring probe without liquid-gas separation under strong electromagnetic interference is proposed. We take transformer oil-dissolved acetylene monitoring as an example, an oil-core photonic crystal fiber photothermal interferometry probe is proposed and demonstrates the feasibility of trace oil-dissolved acetylene directly monitoring without oil-gas separation. The minimum detection limit reaches 1.4 ppm, and the response time is about 70 minutes. Due to the good insulation performance and the compact size, the all-fiber probe provides applicability to be placed into transformer oil and perform on-line monitoring under strong electromagnetic interference., Comment: 21 pages, 7 figures

Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular dynamics are reminiscent of leader-follower coordination and epithelial-mesenchymal transitions (EMT) in tissue development, which may occur via dysregulation of associated molecular or physical mechanisms. However, it remains challenging to elucidate such phenotypic heterogeneity and plasticity without precision measurements of single cell behavior. The convergence of technological developments in live cell imaging, biophysical measurements, and 3D biomaterials are highly promising to reveal how tumor cells cooperate in aberrant microenvironments. Here, we highlight new results in collective migration from the perspective of cancer biology and bioengineering. First, we review the biology of collective cell migration. Next, we consider physics-inspired analyses based on order parameters and phase transitions. Further, we examine the interplay of metabolism and heterogeneity in collective migration. We then review the extracellular matrix, and new modalities for mechanical characterization of 3D biomaterials. We also explore epithelial-mesenchymal plasticity and implications for tumor progression. Finally, we speculate on future directions for integrating mechanobiology and cancer cell biology to elucidate collective migration.

The Jiangmen Underground Neutrino Observatory (JUNO) is a multi-purpose neutrino experiment. One of the main goals is to determine the neutrino mass ordering by precisely measuring the energy spectrum of reactor antineutrinos. For reactor antineutrino detection, cosmogenic backgrounds such as $^9$Li/$^8$He and fast neutrons induced by cosmic muons should be rejected carefully by applying muon veto cuts, which requires good muon track reconstruction. With a 20~kton liquid scintillator detector, simulation shows the proportion of muon bundles to be around 8\% in the JUNO, while its reconstruction is rarely discussed in previous experiments. According to the charge response of the PMT array, this paper proposes an efficient algorithm for muon bundle track reconstruction. This is the first reconstruction of muon bundles in a large volume liquid scintillator detector. Additionally, the algorithm shows good performance and potential in reconstruction for both single muon and double muons. The spatial resolution of single muon reconstruction is 20~cm and the angular resolution is $0.5^\circ$. As for double muon reconstruction, the spatial resolution and angular resolution could be 30~cm and $1.0^\circ$, respectively. Moreover, this paper has also discussed muon classification and veto strategy.