Search

Your search keyword '"Guillerm G"' showing total 302 results
Start Over Author "Guillerm G"
302 results on '"Guillerm G"'

51. Major Superiority of Melphalan - Prednisone (MP) + Thalidomide (THAL) over MP and Autologous Stem Cell Transplantation in the Treatment of Newly Diagnosed Elderly Patients with Multiple Myeloma.

Author

Facon, Thierry, primary, Mary, J.Y., primary, Hulin, C., primary, Benboubker, L., primary, Attal, M., primary, Renaud, M., primary, Harousseau, J.L., primary, Pegourie, B., primary, Guillerm, G., primary, Chaleteix, C., primary, Dib, M., primary, Voillat, L., primary, Maisonneuve, H., primary, Troncy, J., primary, Dorvaux, V., primary, Monconduit, M., primary, Martin, C., primary, Casassus, P., primary, Jaubert, J., primary, Jardel, H., primary, Kolb, B., primary, and Bauters, F., primary

Published
2005
Full Text
View/download PDF

52. A Multicenter Prospective Randomized Study Testing Non-Inferiority of Thalidomide 100 mg/day as Compared with 400 mg/day in Patients with Refractory/Relapsed Multiple Myeloma: First Results of the Final Analysis of the IFM 01-02 Study.

Author

Yakoub-Agha, Ibrahim, primary, Hulin, C., primary, Doyen, C., primary, Benboubker, L., primary, Voillat, L., primary, Bouabdallah, K., primary, Guillerm, G., primary, Moreau, P., primary, Maloisel, F., primary, Stoppa, A.M., primary, Pegourie, B., primary, Rodon, P., primary, Dib, M., primary, Casassus, P., primary, Slama, B., primary, Voog, E., primary, Jardel, H., primary, Collet, P., primary, Wettervald, M., primary, Peny, A.M., primary, Mineur, P., primary, Duguet, C., primary, Zerbib, R., primary, Facon, T., primary, and Mary, J.Y., primary

Published
2005
Full Text
View/download PDF

53. Blockade of p110delta Isoform Activity of Phosphoinositide 3-Kinase Inhibits Blast Cell Proliferation in Acute Myeloblastic Leukemia.

Author

Bouscary, D., primary, Bardet, V., primary, Sujobert, P., primary, Cornillet-Lefebvre, P., primary, Hayflick, J. S., primary, Prie, N., primary, Verdier, F., primary, Vanhaesebroeck, B., primary, Muller, O., primary, Pesce, F., primary, Ifrah, N., primary, Berger, M. Hunault, primary, Bertho, C., primary, Guillerm, G., primary, Villemagne, B., primary, Audhui, B., primary, Solary, E., primary, Witz, F., primary, Harousseau, J. L., primary, Himberlin, C., primary, Lamy, T., primary, Lioure, B., primary, Bene, M. C., primary, Cahn, J. Y., primary, Dreyfus, F., primary, Mayeux, P., primary, and Lacombe, C., primary

Published
2004
Full Text
View/download PDF

67. Non-Hodgkin's lymphoma.

Author

Yakoub-Agha, I., Fawaz, A., Folliot, O., Guillerm, G., Quesnel, B., Fenaux, P., Bauters, F., Jouet, J.P., and Morschhauser, F.

Subjects
BONE marrow transplantation, LYMPHOMAS, GRAFT versus host disease
Abstract

Provides information on allogeneic bone marrow transplantation in patients with follicular lymphoma. Graft-versus-lymphoma effect of the transplantation; Reason for the need to define indications and use of prospective protocols involving less toxic transplant procedure; Effect of myeloablative conditioning regimens on post-transplant morbidity and mortality.

Published
2002
Full Text
View/download PDF

68. INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE WITH FLUORINATED ANALOGS OF 2′- AND 3′-DEOXY-5′-METHYLTHIOADENOSINE.

Author

Guillerm, D., Guillerm, G., and Witkowski-Vandenplas, C.

Subjects
*ADENOSINES, *HYDROLASES, *MASS spectrometry, *ENZYMES
Abstract

Fluorinated analogs of 2′- and 3′-deoxy-5′-methylthioadenosine 1–4 caused irreversible inactivation of AdoHcy hydrolase. Based on the ESI-Mass spectra analysis of the inactivated enzyme with the fluorinated analog 1 a mechanism of inactivation is proposed. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

69. MECHANISM OF INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE BY 5′-DEOXY-5′-S-ALLENYLTHIOADENOSINE AND 5′-DEOXY-5′-S-PROPYNYLTHIOADENOSINE.

Author

Guillerm, G., Guillerm, D., and Witkowski-Vandenplas, C.

Subjects
*ADENOSINES, *HYDROLASES, *MASS spectrometry, *ENZYMES
Abstract

5′-Deoxy-5′-S-allenylthioadenosine 1 and 5′-deoxy-5′-S-propnylthioadenosine 2, derived from adenosine, were prepared. 1 and 2 caused irreversible inactivation of AdoHcy hydrolase. ESI mass spectra analysis of the inactivated enzyme demonstrated that 1 and 2 were type II “mechanism-based” inhibitors. [ABSTRACT FROM AUTHOR]

Published
2001
Full Text
View/download PDF

72. Synthesis, Mechanism of Action, and Antiviral Activity of a New Series of Covalent Mechanism-Based Inhibitors of S-Adenosyl-<SCP>l</SCP>-Homocysteine Hydrolase

Author

Guillerm, G., Guillerm, D., Vandenplas-Witkowki, C., Rogniaux, H., Carte, N., Leize, E., Dorsselaer, A. Van, Clercq, E. De, and Lambert, C.

Abstract

A direct method for the preparation of 5‘-S-alkynyl-5‘-thioadenosine and 5‘-S-allenyl-5‘-thioadenosine has been developed. Treatment of a protected 5‘-acetylthio-5‘-deoxyadenosine with sodium methoxide and propargyl bromide followed by deprotection gave the 5‘-S-propargyl-5‘-thioadenosine 4. Under controlled base-catalysis with sodium tert-butoxide in tert-butyl alcohol 4 was quantitatively converted into 5‘-S-allenyl-5‘-thioadenosine 5 or 5‘-S-propynyl-5‘-thioadenosine 6. Incubation of recombinant human placental AdoHcy hydrolase with 4, 5, or 6 resulted in time- and concentration-dependent inactivation of the enzyme (Ki: 45 ± 0.5, 16 ± 1, and 15 ± 1 μM, respectively). Compound 4 caused complete conversion of the enzyme from its E-NAD+ to E-NADH form during the inactivation process. This indicates that 4 is a substrate for the 3‘-oxidative activity of AdoHcy hydrolase (type I inhibitor). In contrast, the NAD+/NADH content of the enzyme was not affected during the inactivation process with 5 and 6, and their mechanism of inactivation was further investigated. Addition of enzyme-sequestered water on the S-allenylthio group of 5 or S-propynylthio group of 6 within the active site should lead to the formation of the corresponding thioester 7. This acylating-intermediate agent could then undergo nucleophilic attack by a protein residue, leading to a type II mechanism-based inactivation. ElectroSpray mass spectra analysis of the inactivated protein by 5 supports this mechanistic proposal. Further studies (MALDI-TOF and ESI/MSn experiments) of the trypsin and endo-Lys-C proteolytic cleavage of the fragments of inactivated AdoHcy hydrolase by 5 were carried out for localization of the labeling. The antiviral activity of 4, 5, and 6 against a large variety of viruses was determined. Significant activity (EC50: 1.9 μM) was noted with 5 against vaccinia virus.

Published
2001

77. The survival after allogeneic stem cell transplantation for blast crisis chronic myelogenous leukaemia relies on disease status prior to transplant and on the EBMT score, in the tyrosine kinase inhibitors era

Author

Labussiere, H., Milpied, N., Socie, G., Yakoub-Agha, I., Mohty, M., Fegueux, N., Tilly, H., Didier Blaise, Bordigoni, P., Bilger, K., Cordonnier, C., Dalle, J-H, Revel, T., Deconinck, E., Rio, B., Sirvent, A., Ifrah, N., Guillerm, G., Mialou, V., Buzyn, A., Huynh, A., Bay, J. O., Raus, N., Morisset, S., Michallet, M., and Nicolini, F.

78. Allogeneic Stem Cell Transplantation for Blast Crisis (BC) Chronic Myelogenous Leukemia (CML) In the Tyrosine Kinase Inhibitors (TKIs) Era. Analysis of Pre-Transplant Variables on Transplant Outcome. On Behalf of the Societe Francaise De Greffe De Moelle Et De Therapie Cellulaire and the French Group of CML

Author

Nicolini, F., Modolo, L., Raus, N., Milpied, N., Socie, G., Ibrahim Yakoub-Agha, Mohty, M., Fegueux, N., Tilly, H., Blaise, D., Bordigoni, P., Bilger, K., Cordonnier, C., Dalle, J. H., Revel, T., Deconninck, E., Rio, B., Sirvent, A., Ifrah, N., Guillerm, G., Mialou, V., Buzyn, A., Huynh, A., Bay, J. O., Morisset, S., and Michallet, M.

79. Allogeneic haematopoietic stem cell transplantation for Hodgkin's lymphoma: a retrospective study from the French Society of Bone Marrow Graft Transplantation and Cellular Therapy (SFGM-TC)

Author

Marcais, A., Bilger, K., Mohty, M., Didier Blaise, Michalet, M., Vigouroux, S., Bordigoni, P., Ceballos, P., Deconinck, E., Dehdin, N., Rio, B., Bay, J. O., Garban, F., Ifrah, N., Guillerm, G., Agha, I. Yakou, Contentin, N., Pautas, C., Bourhis, J. H., Bernard, M., Cornillon, J., Huynh, A., Sirvent, A., Fouillard, L., Milpied, N., and Buzyn, A.

80. CIoB2A2 Reduced-Intensity Conditioning (RIC) Regimen Prior to Allogeneic Stem Cell Transplantation Provides Significant Better Survival Compared to FB2A2 RIC Regimen in Adults with Acute Myeloid Leukemia (AML): A Study on Behalf of the SFGM-TC

Author

Chevallier, P., Labopin, M., La Tour, R. P., Lioure, B., Cahn, J. Y., Huynh, A., Blaise, D., Turlure, P., Deconinck, E., Maillard, N., Ibrahim Yakoub-Agha, Guillerm, G., Fegueux, N., Contentin, N., Bay, J. O., Beckerich, F., Bourhis, J. H., Detrait, M. Y., Vigouroux, S., Francois, S., Legrand, F., Raus, N., Guillaume, T., and Mohty, M.

81. Outcomes of hematopoietic stem cell transplant for extranodal natural killer/T-cell lymphoma, nasal type: A study from the Societe Francophone de Greffe de Moelle et de Therapie cellulaire

Author

Philippe, L., Jaccard, A., Puyraveau, M., Courone, L., Sandy, A., Bachy, E., Banos, A., Bergerat, J-P, Berthou, C., Didier Blaise, Bourhis, J-H, Bulabois, C-E, Cahn, J-Y, Sylvain, C., Chevalier, P., Cornillon, J., Devidas, A., Drenoub, B., Faucher, C., Feugier, P., Francois, S., Gyan, E., Glaisner, S., Guillerm, G., Guyotat, D., Haoun, C., Huynh, A., Bay, J-O, Malfuson, J-V, Labussiere-Wallet, H., Leblond, V., Lengay, S., Lioure, B., Michallet, M., Milpied, N., Mohty, M., Moreau, P., Nguyenquoc, S., Ojeda-Uribem, M., Plantier, I., Rousselot, P., Rubio, M-T, Fontbrune, F. Sicre, Sirvent, N., Socie, G., Tabrizi, R., Revel, T., Thieblemont, C., Turlure, P., Yakoubagha, I., La Tour, R. Peffault, and Hermine, O.

83. Allogeneic Stem Cell Transplantation Offers Similar Outcome After Myeloablative and Sequential Conditioning Regimen in Patients with Refractory or Relapsed Acute Myeloid Leukemia (AML): a study from the SFGM-TC

Author

Decroocq, J., Itzykson, R., Vigouroux, S., Michallet, M., Ibrahim Yakoub-Agha, Beckerich, F., Huynh, A., Suarez, F., Chevallier, P., Quoc, S. N., Lioure, B., Clement, L., Fegueux, N., Contentin, N., Guillerm, G., Cornillon, J., Carre, M., Maillard, N., Mercier, M., Mohty, M., Beguin, Y., Bourhis, J. H., Charbonnier, A., Jubert, C., Dauriac, C., Bay, J. O., Blaise, D., Deconinck, E., Raus, N., La Tour, R. P., and Dhedin, N.

84. Factorization of a 512 bit RSA modulus

Author

Cavallar, S., Dodson, B., Lenstra, Arjen K., Lioen, W., Montgomery, P. L., Murphy, B., te Riele, H., Aardal, K., Gilchrist, J., Guillerm, G., Leyland, P., Marchand, J., Morain, F., Muffett, A., Putnam, C., and Zimemrmann, P.

Subjects
cryptography, Hardware_ARITHMETICANDLOGICSTRUCTURES
Abstract

This paper reports on the factorization of the 512 bit number RSA-155 by the number field Sieve factoring method (NFS) and discusses the implications for RSA

85. Therapeutic management of patients relapsing after allogeneic haematopoietic stem cell transplantation for myelodysplastic syndrome: a large-scale study on behalf of the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC)

Author

Guieze, R., Damaj, G., Robin, M., Mohty, M., Michallet, M., Tabrizi, R., Beguin, Y., Didier Blaise, Roosweil, D., Bulabois, C. -E, Legrand, F., Huynh, A., Cornillon, J., Contentin, N., Suarez, F., Lioure, B., Maillard, N., Clement, L., Guillerm, G., Rubio, M. -T, Garnier, F., and Yakoub-Agha, I.

86. EFFECT OF IMMUNOMODULATION FOR PERIPHERAL T-CELL LYMPHOMA IN RELAPSE AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT: A SFGM-TC STUDY ON 64 PATIENTS

Author

Mamez, A. C., Levy, V., Chevallier, P., Vigouroux, S., Xhaard, A., Contentin, N., Mohty, M., Ibrahim Yakoub-Agha, Bulabois, C. E., Deconink, E., Lamy, T., Huynh, A., Fegueux, N., Turlure, P., Maury, S., Beguin, Y., Bourhis, J. H., Bilger, K., Bay, J. O., Guillerm, G., Suarez, F., Maillard, N., Rialland, F., Jubert, C., and Quoc, S. N.

Catalog

Books, media, physical & digital resources
See catalog results