Search

Your search keyword '"Guilhot, Christophe"' showing total 329 results
Start Over Author "Guilhot, Christophe"
329 results on '"Guilhot, Christophe"'

52. CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy

Author

Doz-Deblauwe, Emilie, Carreras, Florence, Arbues, Ainhoa, Remot, Aude, Epardaud, Mathieu, Malaga, Wladimir, Mayau, Véronique, Prandi, Jacques, Astarie-Dequeker, Catherine, Guilhot, Christophe, Demangel, Caroline, Winter, Nathalie, ISP, Infectiologie et Santé Publique, INRA, Université de Tours, Nouzilly, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Immunobiologie de l'Infection - Immunobiology of Infection, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris], ANR-2011-BSV3-0001 PGLECT, Région Centre Val de Loire (No. 32000584 Inflammation et Infection), bourse du programme France Futur Elevage, ANR-11-BSV3-0001,PGLECT,Interaction PGL/lectines et modulation de la réponse immunitaire par les mycobactéries pathogènes(2011), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
Male, lcsh:Immunologic diseases. Allergy, NFAT, Neutrophils, dendritic cell, Immunology, Macrophage-1 Antigen, phenol glycolipid-1, chemical and pharmacologic phenomena, macrophage, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Mice, Phagocytosis, Leprosy, Animals, Syk Kinase, Syk, ComputingMilieux_MISCELLANEOUS, Original Research, CR3, Mice, Knockout, Antigens, Bacterial, NFATC Transcription Factors, Calcineurin, neutrophil, hemic and immune systems, Dendritic Cells, Immunity, Innate, Mycobacterium leprae, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Cytokines, [SDV.IMM]Life Sciences [q-bio]/Immunology, Glycolipids, lcsh:RC581-607, Signal Transduction
Abstract

International audience; Mycobacterium leprae, the causative agent of leprosy, is unique amongst human pathogens in its capacity to produce the virulence factor phenolic glycolipid (PGL)-I. In addition to mediating bacterial tropism for neurons, PGL-I interacts with Complement Receptor (CR)3 on macrophages (MPs) to promote infection. We demonstrate here that PGL-I binding to CR3 also enhances bacterial invasion of both polymorphonuclear neutrophils (PMNs) and dendritic cells (DCs). Moreover, in all cell types CR3 engagement by PGL-I activates the Syk tyrosine kinase, inducing calcineurin-dependent nuclear translocation of the transcription factor NFATc. This selectively augments the production of IL-2 by DCs, IL-10 by PMNs and IL-1β by MPs. In intranasally-infected mice PGL-I binding to CR3 heightens mycobacterial phagocytosis by lung PMNs and MPs, and stimulates NFATc-controlled production of Syk-dependent cytokines. Our study thus identifies the CR3-Syk-NFATc axis as a novel signaling pathway activated by PGL-I in innate immune cells, rewiring host cytokine responses to M. leprae.

Published
2019
Full Text
View/download PDF

56. The Mycobacterium tuberculosis purine biosynthetic pathway: isolation and characterization of the purC and purL genes

Author

Jackson, Mary, Berthelet, Francois-Xavier, Otal, Isabel, Rauzier, Jean, Martin, Carlos, Gicquel, Brigitte, and Guilhot, Christophe

Subjects
Mycobacterium tuberculosis -- Genetic aspects, Complementation (Genetics) -- Research, Purines -- Research, Biosynthesis -- Research, Biological sciences
Abstract

Genes from the Mycobacterium tuberculosis purine biosynthetic pathway were determined by utilizing purine auxotrophic mutants of Mycobacterium smegmatis. Two methods were used in parallel. In the first method, the M. smegmatics purine auxotrophs were complemented utilizing a M. tuberculosis H37Rv shuttle cosmid library. In the second method, specific probes corresponding to the regions next to the insertion sites of Tn611 in the M. smegmatis genome were employed to screen homologous DNA fragments. Findings indicated high similarities with purC and purL genes form other bacterial and fungal sources.

Published
1996

57. Insertion sequence IS 1137, a new IS3 family element from Mycobacterium smegmatis

Author

Garcia, Maria J., Guilhot, Christophe, Lathigra, Raju, Menendez, M. Carmen, Domenech, Pilar, Moreno, Carlos, Gicquel, Brigitte, and Martin, Carlos

Subjects
Mycobacterium -- Research, Insertion elements, DNA -- Analysis, Biological sciences
Abstract

Analysis of a 1361 bp long new insertion sequence (IS) isolated from Mycobacterium smegmatis reveals that it has characteristics of IS3 family elements. It has 32 bp imperfect inverted repeats and 3bp direct repeats due to a transposition event. Two of the three major open reading frames (ORFs) in this IS, IS1137, exhibit homologies both at organization level and at amino acid sequence level with ORFs encoding the transposases of the IS3 family elements. IS1137 exhibits a narrow host range and its absence in M. tuberculosis complex strains suggests this element as a new candidate for transposon mutagenesis in mycobacteria.

Published
1994

58. Efficient transposition in Mycobacteria: construction of Mycobacterium smegmatis insertional mutant libraries

Author

Guilhot, Christophe, Otal, Isabel, Rompaey, Ingrid van, Martin, Carlos, and Gicquel, Brigitte

Subjects
Mycobacterium -- Research, Transposons -- Analysis, Mutation (Biology) -- Observations, Biological sciences
Abstract

Plasmid, pCG79, obtained from Tn611 transposon insertion into pCG63, a temperature-sensitive plasmid isolated from an Escherichia coli mycobacterial shuttle vector with pAL5000 and pUC18 replicons, provided several insertional mutations in Mycobacterium smegmatis. This is the first time when straightforward transposition into a mycobacterium was utilized to build mycobacterial insertional mutant libraries. Preferential insertion regions were not identified.

Published
1994

64. Mycobacterium leprae pgl1 expression by BCG increases CR3 mediated entry into mouse myeloid cells and induces Syk/NFAT cytokine production

Author

Doz-Deblauwe, Emilie, Carreras, Florence, Remot, Aude, Epardaud, Mathieu, Demangel, Caroline, Guilhot, Christophe, Winter, Nathalie, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Institut Pasteur [Paris], Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut National de la Recherche Agronomique (INRA)-Université de Tours, Institut Pasteur [Paris] (IP), Université Toulouse III - Paul Sabatier (UT3), and Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)

Subjects
NFAT, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, mycobactéries, ComputingMilieux_MISCELLANEOUS, complement receptor 3
Abstract

Posters Session 1 : Dialogues agresseurs-hôtes, adaptations réciproques; National audience

Published
2018

70. Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response

Author

Alonso, Henar, Parra, Julien, Malaga, Wladimir, Payros, Delphine, Liu, Chia-Fang, Berrone, Céline, Robert, Camille, Meunier, Etienne, Burlet-Schiltz, Odile, Rivière, Michel, Guilhot, Christophe, Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Laboratoire Arts et Métiers ParisTech d'Angers (LAMPA), École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Polarisation des Macrophages et Récepteurs Nucléaires dans les Pathologies Inflammatoires et Infectieuses, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR50, Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Laboratoire Angevin de Mécanique, Procédés et InnovAtion (LAMPA), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Arts et Métiers Sciences et Technologies, IFR50-Université Toulouse III - Paul Sabatier (UT3), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)-Arts et Métiers Sciences et Technologies, and HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Université de Bordeaux (UB)

Subjects
Inflammation, Lipopolysaccharides, Mice, Inbred BALB C, Glycosylation, Virulence Factors, Science, Mycobacterium smegmatis, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, Mycobacterium tuberculosis, bacterial infections and mycoses, Toll-Like Receptor 2, Article, carbohydrates (lipids), Bacterial Proteins, hemic and lymphatic diseases, Medicine, Animals, Female, lipids (amino acids, peptides, and proteins), Mannose, Gene Deletion, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Protein O-mannosylation is crucial for the biology of Mycobacterium tuberculosis but the key mannosylated protein(s) involved and its(their) underlying function(s) remain unknown. Here, we demonstrated that the M. tuberculosis mutant (Δpmt) deficient for protein O-mannosylation exhibits enhanced release of lipoarabinomannan (LAM) in a complex with LprG, a lipoprotein required for LAM translocation to the cell surface. We determined that LprG is O-mannosylated at a unique threonine position by mass spectrometry analyses of the purified protein. However, although replacement of this amino acid by an alanine residue completely abolished LprG O-mannosylation, the increased release of the LAM/LprG complex was preserved. We found that the increased secretion of this complex is due to enhanced LAM production in the Δpmt M. tuberculosis and M. smegmatis mutants relative to their wildtype counterparts. This abnormal release of LAM/LprG has functional consequences on the induction of inflammatory responses and provides a possible explanation for the reduced virulence of the M. tuberculosis Δpmt mutant.

Published
2017
Full Text
View/download PDF

71. TBVAC2020 : advancing tuberculosis vaccines from discovery to clinical development

Author

Kaufmann, Stefan H. E., Dockrell, Hazel M., Drager, Nick, Ho, Mei Mei, McShane, Helen, Neyrolles, Olivier, Ottenhoff, Tom H. M., Patel, Brij, Roordink, Danielle, Spertini, François, Stenger, Steffen, Thole, Jelle, Verreck, Frank A. W., Williams, Ann, Britton, Warwick, Triccas, Jamie, Counoupas, Claudio, Grooten, Johan, Marie-Ange Demoitie, Demoitie, Romano, Marta, Huygen, Kris, Tima, Hermann Giresse, Mascart, Francoise, Andersen, Peter, Aagaard, Claus, Christensen, Dennis, Ruhwald, Morten, Lindenstrom, Thomas, Charneau, Pierre, Guilhot, Christophe, Peixoto, Antonio, Gilleron, Martine, Vergne, Isabelle, Locht, Camille, Brosch, Roland, Inchauspe, Genevieve, Theung Long, Stephane Leung, Weiner, January, Maertzdorf, Jeroen, Nieuwenhuizen, Natalie, Bastian, Max, Kallert, Stephanie, Gordon, Stephen, Caccamo, Nadia, Goletti, Delia, Nisini, Roberto, Shin, Sung Jae, Cho, Sang Nae, Lee, Hyejon, Perrie, Yvonne, and TBVAC2020 Consortium

Subjects
QR180
Abstract

TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early clinical assessment. The project builds on previous collaborations from 1998 onwards funded through the EC framework programs FP5, FP6, and FP7. It has succeeded in attracting new partners from outstanding laboratories from all over the world, now totaling 40 institutions. Next to the development of novel vaccines, TB biomarker development is also considered an important asset to facilitate rational vaccine selection and development. In addition, TBVAC2020 offers portfolio management that provides selection criteria for entry, gating, and priority settings of novel vaccines at an early developmental stage. The TBVAC2020 consortium coordinated by TBVI facilitates collaboration and early data sharing between partners with the common aim of working toward the development of an effective TB vaccine. Close links with funders and other consortia with shared interests further contribute to this goal.

Published
2017

72. PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves

Author

Díaz Acosta, Chyntia Carolina, primary, Dias, André Alves, additional, Rosa, Thabatta Leal Silveira Andrezo, additional, Batista-Silva, Leonardo Ribeiro, additional, Rosa, Patricia Sammarco, additional, Toledo-Pinto, Thiago Gomes, additional, Costa, Fabrício da Mota Ramalho, additional, Lara, Flávio Alves, additional, Rodrigues, Luciana Silva, additional, Mattos, Katherine Antunes, additional, Sarno, Euzenir Nunes, additional, Bozza, Patrícia Torres, additional, Guilhot, Christophe, additional, de Berrêdo-Pinho, Márcia, additional, and Pessolani, Maria Cristina Vidal, additional

Published
2018
Full Text
View/download PDF

74. ESX-1 and phthiocerol dimycocerosates ofMycobacterium tuberculosisact in concert to cause phagosomal rupture and host cell apoptosis

Author

Augenstreich, Jacques, primary, Arbues, Ainhoa, additional, Simeone, Roxane, additional, Haanappel, Evert, additional, Wegener, Alice, additional, Sayes, Fadel, additional, Le Chevalier, Fabien, additional, Chalut, Christian, additional, Malaga, Wladimir, additional, Guilhot, Christophe, additional, Brosch, Roland, additional, and Astarie-Dequeker, Catherine, additional

Published
2017
Full Text
View/download PDF

75. Les bacilles de la tuberculose bovine

Author

Brosch, Roland, Guilhot, Christophe, Pathogénomique mycobactérienne intégrée, Institut Pasteur [Paris] (IP), Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris], Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2015
Full Text
View/download PDF

76. Multiple deletions in the polyketide synthase gene repertoire of Mycobacterium tuberculosis reveal functional overlap of cell envelope lipids in host-pathogen interactions

Author

Passemar, Charlotte, Arbués, Ainhoa, Malaga, Wladimir, Mercier, Ingrid, Moreau, Flavie, Lepourry, Laurence, Neyrolles, Olivier, Guilhot, Christophe, Astarie-Dequeker, Catherine, Institut de pharmacologie et de biologie structurale (IPBS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Dynamique Musculaire et Métabolisme (DMEM), Université de Montpellier (UM)-Institut National de la Recherche Agronomique (INRA), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
Virulence, Macrophages, [SDV]Life Sciences [q-bio], Mycobacterium tuberculosis, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Lipid Metabolism, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Disease Models, Animal, Mice, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Host-Pathogen Interactions, Animals, Humans, Tuberculosis, [SDV.IMM]Life Sciences [q-bio]/Immunology, Lung, Polyketide Synthases, Cells, Cultured, Gene Deletion, Spleen, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Several specific lipids of the cell envelope are implicated in the pathogenesis of M. tuberculosis (Mtb), including phthiocerol dimycocerosates (DIM) that have clearly been identified as virulence factors. Others, such as trehalose-derived lipids, sulfolipids (SL), diacyltrehaloses (DAT) and polyacyltrehaloses (PAT), are believed to be essential for Mtb virulence, but the details of their role remain unclear. We therefore investigated the respective contribution of DIM, DAT/PAT and SL to tuberculosis by studying a collection of mutants, each with impaired production of one or several lipids. We confirmed that among those with a single lipid deficiency, only strains lacking DIM were affected in their replication in lungs and spleen of mice in comparison to the WT Mtb strain. We found also that the additional loss of DAT/PAT, and to a lesser extent of SL, increased the attenuated phenotype of the DIM-less mutant. Importantly, the loss of DAT/PAT and SL in a DIM-less background also affected Mtb growth in human monocyte-derived macrophages (hMDMs). Fluorescence microscopy revealed that mutants lacking DIM or DAT/PAT were localized in an acid compartment and that bafilomycin A1, an inhibitor of phagosome acidification, rescued the growth defect of these mutants. These findings provide evidence for DIM being dominant virulence factors that mask the functions of lipids of other families, notably DAT/PAT and to a lesser extent of SL, which we showed for the first time to contribute to Mtb virulence.

Published
2014
Full Text
View/download PDF

79. pks5-recombination-mediated surface remodelling in Mycobacterium tuberculosis emergence

Author

Boritsch, Eva C., primary, Frigui, Wafa, additional, Cascioferro, Alessandro, additional, Malaga, Wladimir, additional, Etienne, Gilles, additional, Laval, Françoise, additional, Pawlik, Alexandre, additional, Le Chevalier, Fabien, additional, Orgeur, Mickael, additional, Ma, Laurence, additional, Bouchier, Christiane, additional, Stinear, Timothy P., additional, Supply, Philip, additional, Majlessi, Laleh, additional, Daffé, Mamadou, additional, Guilhot, Christophe, additional, and Brosch, Roland, additional

Published
2016
Full Text
View/download PDF

80. Mycobacterium leprae PG-1 production by BCG favors CR3 mediated entry into mouse myeloid cells and incrases SYK-controlled cytokine production

Author

Doz, Emilie, Carreras, Florence, Guilhot, Christophe, Winter, Nathalie, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, and Institut National de la Recherche Agronomique (INRA)-Université de Tours

Subjects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2013

81. Mycobacterium leprae PGL1 expression by BCG increases CR3 mediated entry into different myeloid cells

Author

Doz, Emilie, Carreras, Florence, Guilhot, Christophe, Winter, Nathalie, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Centre National de la Recherche Scientifique (CNRS). FRA., and Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)

Subjects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2013

82. ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis.

Author

Augenstreich, Jacques, Arbues, Ainhoa, Simeone, Roxane, Haanappel, Evert, Wegener, Alice, Sayes, Fadel, Le Chevalier, Fabien, Chalut, Christian, Malaga, Wladimir, Guilhot, Christophe, Brosch, Roland, and Astarie‐Dequeker, Catherine

Subjects
MYCOBACTERIUM tuberculosis, APOPTOSIS, PATHOGENIC microorganisms, MICROBIAL virulence, PROTEINS, ANTIGENS
Abstract

Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their mechanism of action. Localized in the outer membrane of mycobacterial pathogens, DIM are predicted to interact with host cell membranes. Interaction with eukaryotic membranes is a property shared with another virulence factor of Mtb, the early secretory antigenic target EsxA (also known as ESAT-6). This small protein, which is secreted by the type VII secretion system ESX-1 (T7SS/ESX-1), is involved in phagosomal rupture and cell death induced by virulent mycobacteria inside host phagocytes. In this work, by the use of several knock-out or knock-in mutants of Mtb or Mycobacterium bovis BCG strains and different cell biological assays, we present conclusive evidence that ESX-1 and DIM act in concert to induce phagosomal membrane damage and rupture in infected macrophages, ultimately leading to host cell apoptosis. These results identify an as yet unknown function for DIM in the infection process and open up a new research field for the study of the interaction of lipid and protein virulence factors of Mtb. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

88. Multiple deletions in the polyketide synthase gene repertoire ofMycobacterium tuberculosisreveal functional overlap of cell envelope lipids in host-pathogen interactions

Author

Passemar, Charlotte, primary, Arbués, Ainhoa, additional, Malaga, Wladimir, additional, Mercier, Ingrid, additional, Moreau, Flavie, additional, Lepourry, Laurence, additional, Neyrolles, Olivier, additional, Guilhot, Christophe, additional, and Astarie-Dequeker, Catherine, additional

Published
2013
Full Text
View/download PDF

92. Mycobacterium tuberculosis Lineage Influences Innate Immune Response and Virulence and Is Associated with Distinct Cell Envelope Lipid Profiles

Author

Krishnan, Nitya, primary, Malaga, Wladimir, additional, Constant, Patricia, additional, Caws, Maxine, additional, Thi Hoang Chau, Tran, additional, Salmons, Jenifer, additional, Thi Ngoc Lan, Nguyen, additional, Bang, Nguyen Duc, additional, Daffé, Mamadou, additional, Young, Douglas B., additional, Robertson, Brian D., additional, Guilhot, Christophe, additional, and Thwaites, Guy E., additional

Published
2011
Full Text
View/download PDF

94. Mycobacterium leprae Phenolglycolipid-1 Expressed by Engineered M. bovis BCG Modulates Early Interaction with Human Phagocytes

Author

Tabouret, Guillaume, primary, Astarie-Dequeker, Catherine, additional, Demangel, Caroline, additional, Malaga, Wladimir, additional, Constant, Patricia, additional, Ray, Aurélie, additional, Honoré, Nadine, additional, Bello, Nana Fatimath, additional, Perez, Esther, additional, Daffé, Mamadou, additional, and Guilhot, Christophe, additional

Published
2010
Full Text
View/download PDF

96. The Phenolic Glycolipid ofMycobacterium tuberculosisDifferentially Modulates the Early Host Cytokine Response but Does Not in Itself Confer Hypervirulence

Author

Sinsimer, Daniel, primary, Huet, Gaelle, additional, Manca, Claudia, additional, Tsenova, Liana, additional, Koo, Mi-Sun, additional, Kurepina, Natalia, additional, Kana, Bavesh, additional, Mathema, Barun, additional, Marras, Salvatore A. E., additional, Kreiswirth, Barry N., additional, Guilhot, Christophe, additional, and Kaplan, Gilla, additional

Published
2008
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results