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A well-organized construction of hybrid metal-organic frameworks (MOFs) with exquisite structures is vital due to their potential applications. Herein, a novel hybrid nanostructure of UiO-66-on-ZIF-67, denoted as MZU-Co

A series of new double perovskite La2–xEuxCaSnO6 (0 ≤ x ≤ 0.8) red phosphors was synthesized by traditional solid-state reaction. The phase, microstructure, photoluminescence (PL) properties, quantum efficiency, and thermal stability of the phosphors were investigated. La2CaSnO6 matrix has a monoclinic double perovskite structure with space group P21/n. Under near-ultraviolet (UV) light at 395 nm, La2–xEuxCaSnO6 phosphors exhibit the most typical red emission peak at 614 nm, which corresponds to 5D0→7F2 electric dipole transition of Eu3+. The optimum Eu3+ doping content is attained at x=0.5, and the La1.5Eu0.5CaSnO6 phosphor shows a moderate quantum efficiency (32.3%) and high color purity (92.2%). Besides, the temperature-dependent spectrum of the phosphor is studied. The emission intensity of Eu3+ at 423 K decreases to 70.94% of the initial intensity at 303 K, and the activation energy ΔE is estimated to be 0.232 eV, suggesting that the phosphors possess good thermal stability. The fabricated w–LED based on the phosphors have higher Ra (89), lower CCT (4539K), and better chromaticity coordinates (0.371, 0.428). These results prove that the Eu3+–doped La2CaSnO6 red phosphor has great potential applications in w–LEDs.

Background and Objectives: We aimed to investigate the role of Wnt2 expression in colorectal cancer (CRC) prognosis and evaluate its potential as a therapeutic target in BRAF-mutated CRC. Materials and Methods: Exactly 136 samples of formalin-fixed paraffin-embedded CRC tissue specimens were obtained from patients who underwent surgical resection for CRC. The gene mutation status of the samples was detected using fluorescence PCR. Wnt2 expression was detected using immunohistochemistry. Survival curves with high Wnt2 expression and BRAF mutations were compared using the Kaplan–Meier method. A nomogram was constructed to determine the estimated overall survival probability. We also predicted the 3-year and 5-year survival rates for patients with high Wnt2 expression and BRAF mutations. In total, 50 samples of BRAF-mutated CRC were collected and detected Wnt2 expression by immunohistochemistry. The Chi-squared test was used to analyze the association between Wnt2 expression and BRAF-mutated CRC. Results: High Wnt2 expression and BRAF mutations are associated with poor prognosis of CRC. Multivariate survival analyses indicated that high Wnt2 expression and BRAF mutations are significant independent predictors of CRC prognosis. Furthermore, high Wnt2 expression was significantly associated with BRAF-mutated CRC, and Wnt2 may be a potential therapeutic target for BRAF-mutated CRC. Conclusions: High Wnt2 expression confers poor prognosis in colorectal cancer and represents a novel therapeutic target in BRAF-mutated CRC.

Pathogens are capable of hijacking immune defense mechanisms, thereby creating a tolerogenic environment for hypermutated malignant cells that arise within the site of infection. Immune checkpoint–oriented immunotherapies have shown considerable promise. Equally important, the epigenetic reprogramming of an immune-evasive phenotype that activates the immune system in a synergistic manner can improve immunotherapy outcomes. These advances have led to combinations of epigenetic- and immune-based therapeutics. We previously demonstrated that Porphyromonas gingivalis isolated from esophageal squamous cell carcinoma (ESCC) lesions represents a major pathogen associated with this deadly disease. In this study, we examined the mechanisms associated with host immunity during P. gingivalis infection and demonstrated that experimentally infected ESCC responds by increasing the expression of B7-H4 and lysine demethylase 5B, which allowed subsequent in vivo analysis of the immunotherapeutic effects of anti–B7-H4 and histone demethylase inhibitors in models of chronic infection and immunity against xenografted human tumors. Using three different preclinical mouse models receiving combined therapy, we showed that mice mounted strong resistance against P. gingivalis infection and tumor challenge. This may have occurred via generation of a T cell–mediated response in the microenvironment and formation of immune memory. In ESCC subjects, coexpression of B7-H4 and KDM5B correlated more significantly with bacterial load than with the expression of either molecule alone. These results highlight the unique ability of P. gingivalis to evade immunity and define potential targets that can be exploited therapeutically to improve the control of P. gingivalis infection and the development of associated neoplasia.

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The comprehensive reform of agricultural water prices is an important policy for promoting the high-quality sustainable development of agriculture and ensuring national water security. In this study, based on farmer survey data from different water price policy implementation areas in the oasis–desert transition zone of the Heihe River Basin (HRB), crops are divided into high-water-consuming crops and low-water-consuming crops based on the average water consumption per hm2. The content of this study consists of two main parts: first, the study explores the response of farmers to different agricultural water price policies by comparing the impact of uniform water price and tiered water price policies on their planting structure. Second, it studies the areas where the tiered water price policy is implemented to verify the impact of price signals on farmers’ production decisions. The results show that, compared with the uniform water price policy, the implementation of the tiered water price policy will significantly reduce the proportion of high-water-consuming crops planted when other conditions remain unchanged. Under the tiered water price policy, the increase in water prices will reduce the proportion of farmers planting high-water-consuming crops, but the difference is not significant. This result reveals that when the opportunity cost of irrigation water increases, farmers will increase the proportion of low-water-consuming crops. The findings also indicate that a higher educational level, improved land inflow, the number of crop types, and satisfaction with the current subsidy policy will help increase the proportion of low-water-consuming crops. However, an increase in the family-cultivated land area will reduce the area of low-water-consuming crops.

New transmission techniques for short-reach optical transmission applications especially datacenter interconnections are highly expected to break current bandwidth bottleneck, among which mode division multiplexing (MDM) based on few-mode fiber (FMF) is promising by exploring different linearly-polarized (LP) modes or mode groups as spatial transmission channels. However, it has been a great challenge to deal with degenerate modes in FMFs. In this paper, a FMF design utilizing multiple ring perturbations in fiber core to suppress modal crosstalk during fiber transmission is firstly proposed and a 6-LP-mode double-ring-core (DRC) FMF is fabricated with a high minimum refractive index difference (min|neff|) of 1.4910-3 among all the modes. Secondly, a novel degenerate-mode-selective coupler (DMSC) converting each degenerate LPmn mode into the LP11 mode in a two-mode fiber is proposed. Then intensity-modulation/direct-detection (IM/DD) MDM transmission scheme without any digital signal processing (DSP) can be realized utilizing mode multiplexer/demultiplexer (MUX/DEMUX) consisting of cascaded mode-selective couplers (MSC) and DMSCs, in which each degenerate or non-degenerate LP mode is considered as an independent transmission channel. Then based on the proposed DRC-FMF and mode MUX/DEMUX, we demonstrate a 4-LP-mode prototype system using commercial single-mode 10 Gbps SFP + modules and 4K video transceivers without any hardware or software modifications. Finally, the intra-LP-mode dispersion (ILMD) effect in a weakly-coupled FMF is analyzed and a modified fixed-analyzer method is proposed for its measurement. Experimental results show that it may be one of the major impairments for IM/DD MDM transmission.

Low-cost non-noble metal catalyst for dehydrogenation of formic acid to hydrogen at near room temperature is considered as a key to promoting commercial technology for clean energy. We have constructed reduced graphene oxide (RGO) self-assembly bonded nickel particles for synthesis of graphene nanosheets embedded with nickel nanoparticles architecture Ni@xRGO. Nitrogen and oxygen co-doped graphene facilitates the adsorption of hydrogen protons from formic acid. Electron transfer ability of Ni@xRGO with active sites is enhanced via Ni–C bond in the interface between the RGO nanosheets and nickel particles, which promoted the C–H bond breaking for dehydrogenation of formic acid. The Ni@0.20RGO has excellent catalytic performance for hydrogen production from formic acid at near room temperature (the yield of hydrogen, 240.0 mL g−1 h−1 at 50 °C), comparable to the most active non-noble metal catalysts.

Ammonium dihydrogen phosphate (NH4H2PO4) was used as an activator and co-dopant to induce the synthesis of N, P co-doped porous carbon nanosheets (NPCNs) from pomelo peel for using as high-performance supercapacitors. Pomelo peel has a unique sponge-like structure in which NH4H2PO4 particles can be evenly embedded. The pore structure and heteroatomic doping amount of NPCNs were controlled by adjusting the pyrolysis temperature. As a result, the optimal sample exhibits high specific capacitance (314 ± 2.6 F g−1) and rate capability (82% of capacitance retention at 20 A g−1). NPCNs-750 was further employed in a symmetrical supercapacitor (NPCNs-750//NPCNs-750 SSC) with 2 M Li2SO4 electrolyte, and exhibits a high energy density of 36 ± 1.5 W h kg−1 at a power density of 1000 W kg−1, with excellent cycling stability with 99% retention after 10,000 cycles. A series of excellent results show that this pollution-free and cost-effective method can be used for the design and preparation of high-performance supercapacitor electrode materials.

In this work, a novel MXene-copolymeric molecularly imprinted hydrogel (FMMIH) with temperature/pH dual response and photothermal conversion performance for selective recognition of cis-diol compounds is successfully prepared. Functionalized MXene becomes an important part of the hydrogel’s skeleton by participating in the free radical polymerization reaction. Therefore, FMMIH exhibits improved mechanical properties and great photothermal conversion performance. Furthermore, based on the temperature/pH dual response, FMMIH can realize the controllable capture and release of ginsenoside Rb1 with cis diol structures through dual recognitions of functional groups and geometric space. Under the conditions of pH 8.5 and 25 °C, the adsorption capacity of FMMIH is 26.3 mg·g−1 and the imprinting factor is 16.4, showing a good imprinting effect. It is worth noting that the volume shrinkage caused by photothermal conversion of the hydrogel is conducive to the elution of template molecules and greatly saves the time of desorption (the desorption efficiency is as high as 89.4% under light conditions for 30 min, which is 3.7 times in dark conditions). These excellent properties make it possible to have broad prospects in many fields such as separation of cis-diol compounds, drug delivery systems, and biosensors.