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1,444 results on '"Guan, Xin-Yuan"'

54. A neural‐related gene risk score for head and neck squamous cell carcinoma.

Author

Tao, Zhuo‐ying, Yang, Wei‐fa, Zhu, Wang‐yong, Wang, Lei‐lei, Li, Kar Yan, Guan, Xin‐yuan, and Su, Yu‐xiong

Subjects
STATISTICS, IMMUNE checkpoint inhibitors, PREDICTIVE tests, HEAD & neck cancer, REGRESSION analysis, RISK assessment, T-test (Statistics), GENE expression profiling, SURVIVAL analysis (Biometry), KAPLAN-Meier estimator, CHI-squared test, DESCRIPTIVE statistics, RESEARCH funding, DATA analysis, SQUAMOUS cell carcinoma, PROPORTIONAL hazards models, OVERALL survival, IMMUNOTHERAPY
Abstract

Objectives: This study aimed to establish a neural‐related gene risk score (NRGRS) for the prediction of head and neck squamous cell carcinoma prognosis and explore its predictive value on the benefit of immune checkpoint inhibitor therapy. Methods: Based on the transcriptome data of HNSCC patients (n = 546) from The Cancer Genome Atlas database, 37 neural‐related hub genes were identified by weighted gene co‐expression network analysis. Four genes (ITGA5, PYGM, GNG7 and ATP2A3) were identified to construct NRGRS using Lasso‐Cox regression method based on the derivation cohort and validated in the Gene Expression Omnibus cohort (n = 109). The survival analysis was performed to validate the prognostic value of NRGRS and immune characteristics in NRGRS‐defined subgroups were analyzed. Results: NRGRS‐high patients had a worse overall survival than NRGRS‐low patients. Tumors with high NRGRS were more likely to have high infiltration of naive CD4+ T cells, M0, M2 macrophages and resting mast cells, which illustrated suppressive immunity and less benefit from immunotherapy therapy. Conclusion: NRGRS strongly correlates with survival and is a promising biomarker to predict immunotherapy benefits for head and neck cancer patients. This study provides evidence for the potential correlation between neural‐related transcriptome alteration and immune activity. [ABSTRACT FROM AUTHOR]

Published
2024
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55. Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma

Author

Liu, Beilei, primary, Zhang, Baifeng, additional, Qi, Jiali, additional, Zhou, Hongyu, additional, Tan, Licheng, additional, Huang, Jinlin, additional, Huang, Jiao, additional, Fang, Xiaona, additional, Gong, Lanqi, additional, Luo, Jie, additional, Liu, Shan, additional, Fu, Li, additional, Ling, Fei, additional, Ma, Stephianie, additional, Lai-wan Kwong, Dora, additional, Wang, Xin, additional, and Guan, Xin-Yuan, additional

Published
2023
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59. APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production

Author

Wang, Feng-Wei, Cao, Chen-Hui, Han, Kai, Zhao, Yong-Xiang, Cai, Mu-Yan, Xiang, Zhi-Cheng, Zhang, Jia-Xing, Chen, Jie-Wei, Zhong, Li-Ping, Huang, Yong, Zhou, Su-Fang, Jin, Xiao-Han, Guan, Xin-Yuan, Xu, Rui-Hua, and Xie, Dan

Subjects
Cancer patients -- Health aspects, Colorectal cancer -- Care and treatment -- Genetic aspects -- Development and progression, Gene mutation -- Research, Endothelium, Familial polyposis, Antisense RNA, Tumors, Carcinoma, Messenger RNA, Cancer metastasis, Genes, RNA, Health care industry
Abstract

The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains a challenge for drug development. Long noncoding RNAs (lncRNAs) are invaluable in identifying cancer pathologies and providing therapeutic options for patients with cancer. Here, we identified a lncRNA (lncRNA-APC1) activated by APC through lncRNA microarray screening and examined its expression in a large cohort of CRC tissues. A decrease in lncRNAAPC1 expression was positively associated with lymph node and/or distant metastasis, a more advanced clinical stage, as well as a poor prognosis for patients with CRC. Additionally, APC could enhance lncRNA-APC1 expression by suppressing the enrichment of PPAR[alpha] on the lncRNA-APC1 promoter. Furthermore, enforced lncRNA-APC1 expression was sufficient to inhibit CRC cell growth, metastasis, and tumor angiogenesis by suppressing exosome production through the direct binding of Rab5b mRNA and a reduction of its stability. Importantly, exosomes derived from lncRNA-APC1-silenced CRC cells promoted angiogenesis by activating the MAPK pathway in endothelial cells, and, moreover, exosomal Wnt1 largely enhanced CRC cell proliferation and migration through noncanonicial Wnt signaling. Collectively, lncRNA-APC1 is a critical lncRNA regulated by APC in the pathogenesis of CRC. Our findings suggest that an APC-regulated lncRNA-APC1 program is an exploitable therapeutic approach for the treatment of patients with CRC., Introduction As one of the most common human malignancies, colorectal carcinoma (CRC) is a leading cause of cancer-related deaths worldwide. It is well established that the pathogenesis of CRC follows [...]

Published
2019
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70. Loss of ESRP2 Activates TAK1‐MAPK Signaling through the Fetal RNA‐Splicing Program to Promote Hepatocellular Carcinoma Progression.

Author

Yan, Qian, Fang, Xiaona, Liu, Xiaoxia, Guo, Sai, Chen, Siqi, Luo, Min, Lan, Ping, and Guan, Xin‐Yuan

Subjects
HEPATOCELLULAR carcinoma, ALTERNATIVE RNA splicing, RNA splicing, CARCINOEMBRYONIC antigen, IMMUNE checkpoint proteins, GENE expression
Abstract

Tumors usually display fetal‐like characteristics, and many oncofetal proteins have been identified. However, fetal‐like reprogramming of RNA splicing in hepatocellular carcinoma (HCC) is poorly understood. Here, it is demonstrated that the expression of epithelial splicing regulatory protein 2 (ESRP2), an RNA splicing factor, is suppressed in fetal hepatocytes and HCC, in parallel with tumor progression. By combining RNA‐Seq with splicing analysis, it is identified that ESRP2 controls the fetal‐to‐adult switch of multiple splice isoforms in HCC. Functionally, ESRP2 suppressed cell proliferation and migration by specifically switching the alternative splicing (AS) of the TAK1 gene and restraining the expression of the fetal and oncogenic isoform, TAK1_ΔE12. Notably, aberrant TAK1 splicing led to the activation of p38MAPK signaling and predicted poor prognosis in HCC patients. Further investigation revealed that TAK1_ΔE12 protein interacted closely with TAB3 and formed liquid condensation in HCC cells, resulting in p38MAPK activation, enhanced cell migration, and accelerated tumorigenesis. Loss of ESRP2 sensitized HCC cells to TAK1 kinase inhibitor (TAK1i), promoting pyroptotic cell death and CD8+ T cell infiltration. Combining TAK1i with immune checkpoint therapy achieved potent tumor regression in mice. Overall, the findings reveal a previously unexplored onco‐fetal reprogramming of RNA splicing and provide novel therapeutic avenues for HCC. [ABSTRACT FROM AUTHOR]

Published
2024
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72. Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma

Author

Loong, Jane H.C., Wong, Tin-Lok, Tong, Man, Sharma, Rakesh, Zhou, Lei, Ng, Kai-Yu, Yu, Hua-Jian, Li, Chi-Han, Man, Kwan, Lo, Chung-Mau, Guan, Xin-Yuan, Lee, Terence K., Yun, Jing-Ping, and Ma, Stephanie K.Y.

Subjects
Glycosylation -- Health aspects, Transferases -- Genetic aspects -- Physiological aspects -- Health aspects, Hepatoma -- Development and progression, Health care industry
Abstract

Rapidly growing tumors often experience hypoxia and nutrient (e.g., glucose) deficiency because of poor vascularization. Tumor cells respond to the cytotoxic effects of such stresses by inducing molecular adaptations that promote clonal selection of a more malignant tumor-initiating cell phenotype, especially in the innermost tumor regions. Here, we report a regulatory mechanism involving fucosylation by which glucose restriction promotes cancer stemness to drive drug resistance and tumor recurrence. Using hepatocellular carcinoma (HCC) as a model, we showed that restricted glucose availability enhanced the PERK/eIF2[alpha]/ATF4 signaling axis to drive fucosyltransferase 1 (FUT1) transcription via direct binding of ATF4 to the FUT1 promoter. FUT1 overexpression is a poor prognostic indicator for HCC. FUT1 inhibition could mitigate tumor initiation, self-renewal, and drug resistance. Mechanistically, we demonstrated that CD147, ICAM-1, EGFR, and EPHA2 are glycoprotein targets of FUT1, in which such fucosylation would consequently converge on deregulated AKT/mTOR/4EBP1 signaling to drive cancer stemness. Treatment with an [alpha]-(1,2)-fucosylation inhibitor sensitized HCC tumors to sorafenib, a first-line molecularly targeted drug used for advanced HCC patients, and reduced the tumor-initiating subset. FUT1 overexpression and/or CD147, ICAM-1, EGFR, and EPHA2 fucosylation may be good prognostic markers and therapeutic targets for cancer patients., Introduction Aberrant glycosylation is a hallmark of cancer and is not only a consequence but also a driver of malignant phenotypes, directly impacting key processes supporting tumor progression and metastasis, [...]

Published
2021
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75. Abstract 2441: Identification and characterization of the role of KRT17 in the stemness regulation of hepatocellular carcinoma

Author

Fang, Xiaona, primary, Liu, Shan, additional, Ban, Liuxian, additional, Huang, Jiao, additional, Luo, Jie, additional, Gong, Lanqi, additional, Zhang, Baifeng, additional, Liu, Beilei, additional, Huang, Jinlin, additional, Yang, Yuma, additional, Wong, Ching Ngar, additional, Yan, Qian, additional, and Guan, Xin-Yuan, additional

Published
2023
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80. Supplementary Video S3 from MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer

Author

Wang, Shiyan, primary, Huang, Junzhe, primary, Li, Chuangen, primary, Zhao, Liuyang, primary, Wong, Chi Chun, primary, Zhai, Jianning, primary, Zhou, Yunfei, primary, Deng, Wen, primary, Zeng, Yong, primary, Gao, Shanshan, primary, Zhang, Yanquan, primary, Wang, Guoping, primary, Guan, Xin Yuan, primary, Wei, Hong, primary, Wong, Sunny H., primary, He, Housheng H., primary, Shay, Jerry W., primary, and Yu, Jun, primary

Published
2023
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81. Supplemental Methods and Materials from The RARS–MAD1L1 Fusion Gene Induces Cancer Stem Cell–like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma

Author

Zhong, Qian, primary, Liu, Zhi-Hua, primary, Lin, Zhi-Rui, primary, Hu, Ze-Dong, primary, Yuan, Li, primary, Liu, Yan-min, primary, Zhou, Ai-Jun, primary, Xu, Li-Hua, primary, Hu, Li-Juan, primary, Wang, Zi-Feng, primary, Guan, Xin-Yuan, primary, Hao, Jia-Jie, primary, Lui, Vivian W.Y., primary, Guo, Ling, primary, Mai, Hai-Qiang, primary, Chen, Ming-Yuan, primary, Han, Fei, primary, Xia, Yun-Fei, primary, Grandis, Jennifer R., primary, Zhang, Xing, primary, and Zeng, Mu-Sheng, primary

Published
2023
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82. Supplementary Data from MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer

Author

Wang, Shiyan, primary, Huang, Junzhe, primary, Li, Chuangen, primary, Zhao, Liuyang, primary, Wong, Chi Chun, primary, Zhai, Jianning, primary, Zhou, Yunfei, primary, Deng, Wen, primary, Zeng, Yong, primary, Gao, Shanshan, primary, Zhang, Yanquan, primary, Wang, Guoping, primary, Guan, Xin Yuan, primary, Wei, Hong, primary, Wong, Sunny H., primary, He, Housheng H., primary, Shay, Jerry W., primary, and Yu, Jun, primary

Published
2023
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83. Suppl Figure 3 from FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

Author

Lau, Marco Chi-Chung, primary, Ng, Kai Yu, primary, Wong, Tin Lok, primary, Tong, Man, primary, Lee, Terence K., primary, Ming, Xiao-Yan, primary, Law, Simon, primary, Lee, Nikki P., primary, Cheung, Annie L., primary, Qin, Yan-Ru, primary, Chan, Kwok Wah, primary, Ning, Wen, primary, Guan, Xin-Yuan, primary, and Ma, Stephanie, primary

Published
2023
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84. Supplementary Table S6 from MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer

Author

Wang, Shiyan, primary, Huang, Junzhe, primary, Li, Chuangen, primary, Zhao, Liuyang, primary, Wong, Chi Chun, primary, Zhai, Jianning, primary, Zhou, Yunfei, primary, Deng, Wen, primary, Zeng, Yong, primary, Gao, Shanshan, primary, Zhang, Yanquan, primary, Wang, Guoping, primary, Guan, Xin Yuan, primary, Wei, Hong, primary, Wong, Sunny H., primary, He, Housheng H., primary, Shay, Jerry W., primary, and Yu, Jun, primary

Published
2023
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85. Suppl Figure 1 from FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

Author

Lau, Marco Chi-Chung, primary, Ng, Kai Yu, primary, Wong, Tin Lok, primary, Tong, Man, primary, Lee, Terence K., primary, Ming, Xiao-Yan, primary, Law, Simon, primary, Lee, Nikki P., primary, Cheung, Annie L., primary, Qin, Yan-Ru, primary, Chan, Kwok Wah, primary, Ning, Wen, primary, Guan, Xin-Yuan, primary, and Ma, Stephanie, primary

Published
2023
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86. Supplementary Data from CSTF2-Induced Shortening of the RAC1 3′UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder

Author

Chen, Xin, primary, Zhang, Jia-Xing, primary, Luo, Jun-Hang, primary, Wu, Song, primary, Yuan, Gang-Jun, primary, Ma, Ning-Fang, primary, Feng, Yong, primary, Cai, Mu-Yan, primary, Chen, Ri-Xin, primary, Lu, Jun, primary, Jiang, Li-Juan, primary, Chen, Jie-Wei, primary, Jin, Xiao-Han, primary, Liu, Hai-Liang, primary, Chen, Wei, primary, Guan, Xin-Yuan, primary, Kang, Tie-Bang, primary, Zhou, Fang-Jian, primary, and Xie, Dan, primary

Published
2023
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87. Supplementary Video 1 from ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Author

Wu, Shayi, primary, Chen, Miao, primary, Huang, Jiao, primary, Zhang, Feifei, primary, Lv, Zhaojie, primary, Jia, Yongxu, primary, Cui, Yu-Zhu, primary, Sun, Liang-Zhan, primary, Wang, Ying, primary, Tang, Ying, primary, Verhoeft, Krista R., primary, Li, Yan, primary, Qin, Yanru, primary, Lin, Xiang, primary, Guan, Xin-Yuan, primary, and Lam, Ka-On, primary

Published
2023
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88. Supplementary Video 3 from ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Author

Wu, Shayi, primary, Chen, Miao, primary, Huang, Jiao, primary, Zhang, Feifei, primary, Lv, Zhaojie, primary, Jia, Yongxu, primary, Cui, Yu-Zhu, primary, Sun, Liang-Zhan, primary, Wang, Ying, primary, Tang, Ying, primary, Verhoeft, Krista R., primary, Li, Yan, primary, Qin, Yanru, primary, Lin, Xiang, primary, Guan, Xin-Yuan, primary, and Lam, Ka-On, primary

Published
2023
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89. supplementary information-R from PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism

Author

Li, Yan, primary, Lin, Shuhai, primary, Li, Lei, primary, Tang, Zhi, primary, Hu, Yumin, primary, Ban, Xiaojiao, primary, Zeng, Tingting, primary, Zhou, Ying, primary, Zhu, Yinghui, primary, Gao, Song, primary, Deng, Wen, primary, Zhang, Xiaoshi, primary, Xie, Dan, primary, Yuan, Yunfei, primary, Huang, Peng, primary, Li, Jinjun, primary, Cai, Zongwei, primary, and Guan, Xin-Yuan, primary

Published
2023
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90. Supplementary Video 2 from ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Author

Wu, Shayi, primary, Chen, Miao, primary, Huang, Jiao, primary, Zhang, Feifei, primary, Lv, Zhaojie, primary, Jia, Yongxu, primary, Cui, Yu-Zhu, primary, Sun, Liang-Zhan, primary, Wang, Ying, primary, Tang, Ying, primary, Verhoeft, Krista R., primary, Li, Yan, primary, Qin, Yanru, primary, Lin, Xiang, primary, Guan, Xin-Yuan, primary, and Lam, Ka-On, primary

Published
2023
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91. supplemental data 1 from The RARS–MAD1L1 Fusion Gene Induces Cancer Stem Cell–like Properties and Therapeutic Resistance in Nasopharyngeal Carcinoma

Author

Zhong, Qian, primary, Liu, Zhi-Hua, primary, Lin, Zhi-Rui, primary, Hu, Ze-Dong, primary, Yuan, Li, primary, Liu, Yan-min, primary, Zhou, Ai-Jun, primary, Xu, Li-Hua, primary, Hu, Li-Juan, primary, Wang, Zi-Feng, primary, Guan, Xin-Yuan, primary, Hao, Jia-Jie, primary, Lui, Vivian W.Y., primary, Guo, Ling, primary, Mai, Hai-Qiang, primary, Chen, Ming-Yuan, primary, Han, Fei, primary, Xia, Yun-Fei, primary, Grandis, Jennifer R., primary, Zhang, Xing, primary, and Zeng, Mu-Sheng, primary

Published
2023
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94. Suppl Figure Legends and Tables from FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

Author

Lau, Marco Chi-Chung, primary, Ng, Kai Yu, primary, Wong, Tin Lok, primary, Tong, Man, primary, Lee, Terence K., primary, Ming, Xiao-Yan, primary, Law, Simon, primary, Lee, Nikki P., primary, Cheung, Annie L., primary, Qin, Yan-Ru, primary, Chan, Kwok Wah, primary, Ning, Wen, primary, Guan, Xin-Yuan, primary, and Ma, Stephanie, primary

Published
2023
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96. Supplementary Table and Figures from ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Author

Wu, Shayi, primary, Chen, Miao, primary, Huang, Jiao, primary, Zhang, Feifei, primary, Lv, Zhaojie, primary, Jia, Yongxu, primary, Cui, Yu-Zhu, primary, Sun, Liang-Zhan, primary, Wang, Ying, primary, Tang, Ying, primary, Verhoeft, Krista R., primary, Li, Yan, primary, Qin, Yanru, primary, Lin, Xiang, primary, Guan, Xin-Yuan, primary, and Lam, Ka-On, primary

Published
2023
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97. Supplementary Materials and Methods from ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly

Author

Wu, Shayi, primary, Chen, Miao, primary, Huang, Jiao, primary, Zhang, Feifei, primary, Lv, Zhaojie, primary, Jia, Yongxu, primary, Cui, Yu-Zhu, primary, Sun, Liang-Zhan, primary, Wang, Ying, primary, Tang, Ying, primary, Verhoeft, Krista R., primary, Li, Yan, primary, Qin, Yanru, primary, Lin, Xiang, primary, Guan, Xin-Yuan, primary, and Lam, Ka-On, primary

Published
2023
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98. Suppl Figure 5 from FSTL1 Promotes Metastasis and Chemoresistance in Esophageal Squamous Cell Carcinoma through NFκB–BMP Signaling Cross-talk

Author

Lau, Marco Chi-Chung, primary, Ng, Kai Yu, primary, Wong, Tin Lok, primary, Tong, Man, primary, Lee, Terence K., primary, Ming, Xiao-Yan, primary, Law, Simon, primary, Lee, Nikki P., primary, Cheung, Annie L., primary, Qin, Yan-Ru, primary, Chan, Kwok Wah, primary, Ning, Wen, primary, Guan, Xin-Yuan, primary, and Ma, Stephanie, primary

Published
2023
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99. Data from CSTF2-Induced Shortening of the RAC1 3′UTR Promotes the Pathogenesis of Urothelial Carcinoma of the Bladder

Author

Chen, Xin, primary, Zhang, Jia-Xing, primary, Luo, Jun-Hang, primary, Wu, Song, primary, Yuan, Gang-Jun, primary, Ma, Ning-Fang, primary, Feng, Yong, primary, Cai, Mu-Yan, primary, Chen, Ri-Xin, primary, Lu, Jun, primary, Jiang, Li-Juan, primary, Chen, Jie-Wei, primary, Jin, Xiao-Han, primary, Liu, Hai-Liang, primary, Chen, Wei, primary, Guan, Xin-Yuan, primary, Kang, Tie-Bang, primary, Zhou, Fang-Jian, primary, and Xie, Dan, primary

Published
2023
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