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54. Results on mixing and CPV in charm decays at B-Factories

Author

Greenwald, Daniel

Subjects
High Energy Physics::Phenomenology, High Energy Physics::Experiment, Nuclear Experiment
Abstract

Recent results on mixing and CPV in charm decays at B factories. I will present a basic overview of analysis techniques at the B factories BaBar and Belle of importance to mixing and CP-violation measurements in charm. I will then summarize two recent measurements of mixing in D0 decay; and three recent searches for CP violation in charmed-meson decay.

Published
2019
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56. A Phase 1 Trial of Ruxolitinib, Lenalidomide and Methylprednisolone for Patients with Relapsed/Refractory Multiple Myeloma (MM)

Author

Berenson, James R., primary, To, Jennifer, additional, Spektor, Tanya M., additional, Martinez, Daisy, additional, Sanchez, Armando J., additional, Turner, Carley, additional, Swift, Regina, additional, Eades, Benjamin, additional, Schwartz, Gary, additional, Eshaghian, Shahrooz, additional, Stampleman, Laura V., additional, Moss, Robert A., additional, Nassir, Youram, additional, Patel, Ravindranath, additional, Bessudo, Alberto, additional, Greenwald, Daniel, additional, Boccia, Ralph V., additional, Lim, Stephen, additional, and Vescio, Robert, additional

Published
2019
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59. Free tissue transfer to extend the limits of limb salvage for lower extremity tissue loss

Author

Gooden, Michael A., Gentile, Andrew T., Mills, Joseph L., Berman, Scott S., Demas, Christopher P., Reinke, Kurt R., Hunter, Glenn C., Westerband, Alex, Greenwald, Daniel, Albo, Dominic, Jr., and Harris, Frank

Subjects
Skin-grafting -- Evaluation, Flaps (Surgery) -- Evaluation, Extremities, Lower -- Injuries, Health
Abstract

BACKGROUND: The extent of tissue loss amenable to primary healing after revascularization is unknown. Salvage of limbs with large soft-tissue defects with exposed tendon, joint, or bone lies beyond the limits of conventional techniques. We report our results using free tissue transfer as an adjunct to lower extremity vascular reconstruction in patients with complex ischemic or infected wounds. METHODS: Retrospective chart review of patient and wound characteristics. RESULTS: From January 1992 to June 1996, 585 procedures were performed in 544 patients, including 27 free flaps in 26 patients: 17 free flaps combined with distal bypass (7 staged, 10 simultaneous) and 10 isolated free flaps. Flap donor sites included radial forearm (8), latissimus dorsi (7), rectus abdominus (9), and scapula (3). Surgical indications included extensive ischemic/neurotrophic ulcers, and nonhealing vein graft harvest incision or transmetatarsal amputation site. Mean area of tissue loss was 70 [cm.sup.2], mean ulcer duration was 5 months, and 92% of patients had exposed tendon, joint, or bone. During a mean follow-up of 14 months, 2 patients died of cardiopulmonary disease and 3 flaps failed, resulting in below-knee amputation. Six flaps were revised for graft stenosis (1), venous thrombosis (1), or flap edge necrosis (4). Limb salvage rate was 70% at 24 months by life-table analysis. Functional ambulation was achieved in 21 of 24 (88%) patients, including 7 of 8 with diabetes, end-stage renal disease, and heel ulcers. CONCLUSION: In select ambulatory patients with large soft-tissue defects and exposed deep structures, functional limb salvage is obtainable in more than 80% of patients. For lesions not amenable to vascular reconstruction with conventional methods of wound coverage, free tissue transfer extends the limits of limb salvage and is a viable alternative to amputation. Am J Surg. 1997;174:644-649. [C] 1997 by Excerpta Medica, Inc.

Published
1997

62. Phase 2 study of idelalisib and entospletinib: pneumonitis limits combination therapy in relapsed refractory CLL and NHL

Author

Barr, Paul M., Saylors, Gene B., Spurgeon, Stephen E., Cheson, Bruce D., Greenwald, Daniel R., O'Brien, Susan M., Liem, Andre K.D., Mclntyre, Rosemary E., Joshi, Adarsh, Abella-Dominicis, Esteban, Hawkins, Michael J., Reddy, Anita, Di Paolo, Julie, Lee, Hank, He, Joyce, Hu, Jing, Dreiling, Lyndah K., and Friedberg, Jonathan W.

Published
2016
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63. Avadomide (CC-122), a Novel Cereblon Modulating Agent, Plus Rituximab in Patients with Relapsed or Refractory Follicular Lymphoma

Author

Nastoupil, Loretta J., primary, Bijou, Fontanet, additional, Ribrag, Vincent, additional, Chavez, Julio C., additional, Witzig, Thomas E., additional, Andorsky, David J., additional, Klein, Leonard M., additional, Greenwald, Daniel, additional, Santoro, Armando, additional, Corradini, Paolo, additional, Flinn, Ian W., additional, Sangha, Randeep, additional, Kenkre, Vaishalee P., additional, Uttamsingh, Shailaja, additional, Hagner, Patrick R., additional, Gandhi, Anita K., additional, Chen, Tianlei, additional, Hege, Kristen, additional, Pourdehnad, Michael, additional, and Kuruvilla, John, additional

Published
2018
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68. Ublituximab (TG-1101), a novel glycoengineered anti-CD20 antibody, in combination with ibrutinib is safe and highly active in patients with relapsed and/or refractory chronic lymphocytic leukaemia: results of a phase 2 trial

Author

Sharman, Jeff P., primary, Farber, Charles M., additional, Mahadevan, Daruka, additional, Schreeder, Marshall T., additional, Brooks, Heather D., additional, Kolibaba, Kathryn S., additional, Fanning, Suzanne, additional, Klein, Leonard, additional, Greenwald, Daniel R., additional, Sportelli, Peter, additional, Miskin, Hari P., additional, Weiss, Michael S., additional, and Burke, John M., additional

Published
2016
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72. Rare shocks, great recessions

Author

Cúrdia, Vasco, Del Negro, Marco, and Greenwald, Daniel L.

Subjects
DSGE models, fat tails, ddc:330, Bayesian analysis, Great Recession, stochastic volatility, C32, E32
Abstract

We estimate a DSGE model where rare large shocks can occur, but replace the commonly used Gaussian assumption with a Student's t-distribution. Results from the Smets and Wouters (2007) model estimated on the usual set of macroeconomic time series over the 1964-2011 period indicate that 1) the Student's t specification is strongly favored by the data, even when we allow for low-frequency variation in the volatility of the shocks, and 2) the estimated degrees of freedom are quite low for several shocks that drive U.S. business cycles, implying an important role for rare large shocks. This result holds even if we exclude the Great Recession from the sample. We also show that inference about low-frequency changes in volatility - and, in particular, inference about the magnitude of the Great Moderation - is different once we allow for fat tails.

Published
2012

73. Myon-Collider, Frictional Cooling und Universal-Extra-Dimensions

Author

Greenwald, Daniel, Caldwell, Allen (Prof., Ph.D.), and Paul, Stephan (Prof. Dr.)

Subjects
Physik, Muon Collider, Universal Extra Dimensions, Physics::Instrumentation and Detectors, Physics::Accelerator Physics, Myon-Collider, Universal-Extra-Dimensions, High Energy Physics::Experiment, ddc:530
Abstract

A muon collider combines the advantages of proton-proton and electron-positron colliders, sidestepping many of their disadvantages, and has the potential to make discoveries and precision measurements at high energies. However, muons bring their own technical challenges, largely relating to their instability. We present a summary of the motivations and R&D efforts for a muon collider. We detail a scheme for preparing high-luminosity muon beams on timescales shorter than the muon lifetime, and an experiment to demonstrate aspects of this scheme at the Max Planck Institute for Physics. We also investigate the potentials to discover physics beyond the standard model at a muon collider. Ein Myon-Collider vereint die Vorteile eines Proton-Proton- und Elektron-Positron-Colliders und umgeht deren wesentliche Nachteile. Er hat das Potenzial, neue Erkenntnisse auf dem Gebiet der Teilchenphysik zu ermöglichen und erlaubt Präzisionsmessungen bei hohen Energien. Allerdings birgt die Arbeit mit Myonen ihre eigenen technischen Herausforderungen, vor allem aufgrund der Instabilität der Myonen. Im Folgenden werden die Konzepte eines Myon-Colliders sowie die dafür notwendige Forschungs- und Entwicklungsarbeit zusammengefasst. Wir beschreiben detailliert ein System, das auf kleineren Zeitskalen als der Myonlebensdauer zur Gewinnung von Myonenstrahlen mit hoher Luminosität verwendet wird. Wir besprechen ein Experiment, das Aspekte dieses Systems am Max-Planck-Institut für Physik demonstrieren kann. Wir diskutieren auch die Möglichkeiten, Physik jenseits des Standardmodells an einem Myon-Collider zu entdecken.

Published
2011

77. Frictional Cooling for a Slow Muon Source

Author

Bao, Yu, Caldwell, Allen, Greenwald, Daniel, and Xia, Guoxing

Subjects
03 Linear Colliders, Lepton Accelerators and New Acceleration Techniques, A09 Muon Accelerators and Neutrino Factories, Physics::Instrumentation and Detectors, Physics::Accelerator Physics, High Energy Physics::Experiment, Physics::Atomic Physics, Accelerator Physics
Abstract

Low energy muon beams are useful for a wide range of physics experiments. High quality muon beams are also required for muon colliders and neutrino factories. The frictional cooling method holds promise for delivering slow muon beams with narrow energy spreads. With this technology, we consider the production of a cold muon beam from a surface muon source, such as that at the Paul Scherrer Institute. A cooling scheme based on frictional cooling is outlined. Simulation results show that the efficiency of slow muon production can be raised to 1%, which is significantly higher than current schemes., Proceedings of the 1st International Particle Accelerator Conference, IPAC2010, Kyoto, Japan

Published
2010
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78. Frictional Cooling Demonstration Experiment

Author

Greenwald, Daniel, Bao, Yu, and Caldwell, Allen

Subjects
Physics::Accelerator Physics, A14 Advanced Concepts, Accelerator Physics, 01 Circular Colliders
Abstract

Simulations of frictional cooling for a muon collider front end scheme show that it is a viable technique for quickly producing colliding beams. The Frictional Cooling Demonstration experiment at the Max Planck Institute for Physics, Munich, aims to demonstrate the working principle of frictional cooling on protons using a 10-cm-long cooling cell. The experiment is nearing the final data taking stages. The status of the experiment is presented along with recent data. Simulation of the experiment setup is also presented., Proceedings of the 1st International Particle Accelerator Conference, IPAC2010, Kyoto, Japan

Published
2010
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79. A Muon Collider Scheme Based on Frictional Cooling

Author

Greenwald, Daniel, Bao, Yu, and Caldwell, Allen

Subjects
Physics::Instrumentation and Detectors, Physics::Accelerator Physics, High Energy Physics::Experiment, A14 Advanced Concepts, Accelerator Physics, 01 Circular Colliders
Abstract

Muon colliders would open new frontiers of investigation in high energy particle physics, allowing precision measurements to be made at the TeV energy frontier. One of the greatest challenges to constructing a muon collider is the cooling of a beam of muons on a timescale comparable to the lifetime of the muon. Frictional cooling holds promise for use in a muon collider scheme. By balancing energy loss to a gas with energy gain from an electric field, a beam of muons is brought to an equilibrium energy in 100s of nanoseconds. A frictional cooling scheme for producing high-luminosity beams for a muon collider is presented., Proceedings of the 1st International Particle Accelerator Conference, IPAC2010, Kyoto, Japan

Published
2010
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80. Ublituximab (TG-1101), a Novel Glycoengineered Anti-CD20 Monoclonal Antibody, in Combination with Ibrutinib Is Highly Active in Patients with Relapsed and/or Refractory CLL and MCL; Results of a Phase II Trial

Author

Sharman, Jeff P., primary, Farber, Charles M., additional, Mahadevan, Daruka, additional, Schreeder, Marshall T., additional, Brooks, Heather D., additional, Kolibaba, Kathryn S., additional, Fanning, Suzanne R., additional, Klein, Leonard M., additional, Sportelli, Peter, additional, Miskin, Hari P., additional, Weiss, Michael S., additional, and Greenwald, Daniel R., additional

Published
2014
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83. An open-label phase II clinical trial of the RXR agonist IRX4204 in taxane-resistant, castration-resistant metastatic prostate cancer (CRPC).

Author

Kabbinavar, Fairooz F., primary, Zomorodian, Nazy, additional, Rettig, Matthew, additional, Khan, Faraz, additional, Greenwald, Daniel Reif, additional, Davidson, Sheldon J., additional, DiCarlo, Brian Anthony, additional, Patel, Ravi, additional, Pandit, Lalita, additional, Chandraratna, Rosh, additional, and Sanders, Martin, additional

Published
2014
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84. Phase 2 trial of GS-9973, a selective syk inhibitor, and idelalisib (idela) in chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL).

Author

Barr, Paul M., primary, Saylors, Gene Brian, additional, Spurgeon, Stephen Edward Forbes, additional, Cheson, Bruce D., additional, Greenwald, Daniel Reif, additional, O'Brien, Susan Mary, additional, Liem, Andre K. D., additional, McIntyre, Rosemary, additional, Abella-Dominicis, Esteban, additional, Hawkins, Michael J., additional, Reddy, Anita, additional, Di Paolo, Julie, additional, Wu, Meihua, additional, Melchor-Khan, Flordeliza, additional, Jin, Feng, additional, and Friedberg, Jonathan W., additional

Published
2014
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86. Muon Colliders, Frictional Cooling and Universal Extra Dimensions

Author

Paul, Stephan (Prof. Dr.), Caldwell, Allen (Prof., Ph.D.), Greenwald, Daniel, Paul, Stephan (Prof. Dr.), Caldwell, Allen (Prof., Ph.D.), and Greenwald, Daniel

Abstract

A muon collider combines the advantages of proton-proton and electron-positron colliders, sidestepping many of their disadvantages, and has the potential to make discoveries and precision measurements at high energies. However, muons bring their own technical challenges, largely relating to their instability. We present a summary of the motivations and R&D efforts for a muon collider. We detail a scheme for preparing high-luminosity muon beams on timescales shorter than the muon lifetime, and an experiment to demonstrate aspects of this scheme at the Max Planck Institute for Physics. We also investigate the potentials to discover physics beyond the standard model at a muon collider., Ein Myon-Collider vereint die Vorteile eines Proton-Proton- und Elektron-Positron-Colliders und umgeht deren wesentliche Nachteile. Er hat das Potenzial, neue Erkenntnisse auf dem Gebiet der Teilchenphysik zu ermöglichen und erlaubt Präzisionsmessungen bei hohen Energien. Allerdings birgt die Arbeit mit Myonen ihre eigenen technischen Herausforderungen, vor allem aufgrund der Instabilität der Myonen. Im Folgenden werden die Konzepte eines Myon-Colliders sowie die dafür notwendige Forschungs- und Entwicklungsarbeit zusammengefasst. Wir beschreiben detailliert ein System, das auf kleineren Zeitskalen als der Myonlebensdauer zur Gewinnung von Myonenstrahlen mit hoher Luminosität verwendet wird. Wir besprechen ein Experiment, das Aspekte dieses Systems am Max-Planck-Institut für Physik demonstrieren kann. Wir diskutieren auch die Möglichkeiten, Physik jenseits des Standardmodells an einem Myon-Collider zu entdecken.

Published
2011

87. Muon Colliders, Frictional Cooling and Universal Extra Dimensions

Author

Caldwell, Allen (Prof., Ph.D.), Paul, Stephan (Prof. Dr.);Caldwell, Allen (Prof., Ph.D.), Greenwald, Daniel, Caldwell, Allen (Prof., Ph.D.), Paul, Stephan (Prof. Dr.);Caldwell, Allen (Prof., Ph.D.), and Greenwald, Daniel

Abstract

A muon collider combines the advantages of proton-proton and electron-positron colliders, sidestepping many of their disadvantages, and has the potential to make discoveries and precision measurements at high energies. However, muons bring their own technical challenges, largely relating to their instability. We present a summary of the motivations and R&D efforts for a muon collider. We detail a scheme for preparing high-luminosity muon beams on timescales shorter than the muon lifetime, and an experiment to demonstrate aspects of this scheme at the Max Planck Institute for Physics. We also investigate the potentials to discover physics beyond the standard model at a muon collider., Ein Myon-Collider vereint die Vorteile eines Proton-Proton- und Elektron-Positron-Colliders und umgeht deren wesentliche Nachteile. Er hat das Potenzial, neue Erkenntnisse auf dem Gebiet der Teilchenphysik zu ermöglichen und erlaubt Präzisionsmessungen bei hohen Energien. Allerdings birgt die Arbeit mit Myonen ihre eigenen technischen Herausforderungen, vor allem aufgrund der Instabilität der Myonen. Im Folgenden werden die Konzepte eines Myon-Colliders sowie die dafür notwendige Forschungs- und Entwicklungsarbeit zusammengefasst. Wir beschreiben detailliert ein System, das auf kleineren Zeitskalen als der Myonlebensdauer zur Gewinnung von Myonenstrahlen mit hoher Luminosität verwendet wird. Wir besprechen ein Experiment, das Aspekte dieses Systems am Max-Planck-Institut für Physik demonstrieren kann. Wir diskutieren auch die Möglichkeiten, Physik jenseits des Standardmodells an einem Myon-Collider zu entdecken.

Published
2011

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