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This article describes a required capstone course for students in the Global Supply Chain Management (GSCM) Program at Bryant University, designed to prepare students for a career in supply chain management. Student teams work on semester-long projects for locally and regionally based companies. The projects are supported by all GSCM faculty who teach in the Information Systems and Analytics, Management, and Marketing departments. Since the inception of this capstone course in the fall of 2010, a total of 83 projects for 42 companies have been completed. Hence this article discusses an extensive number of projects over an extended period of time, and our insights should be of interest to supply chain faculty who currently have, or plan to include, empirical projects as a key component of their course or supply chain program. We present a brief literature review on teaching supply chain management, and then describe the practicum capstone course, Empirical Applications in Global Supply Chain Management. We provide company and project descriptions and discuss project outcomes. Students have estimated savings/earnings impact of $109.5 million from 35 projects completed over a 4-year period. Although not without challenges, the practicum capstone course provides students with an integrative, multidisciplinary experience that better prepares them for their careers.

Since the beginning of 2020, parallel to the sanitary confinement by Covid, links have circulated in social networks to download titles belonging to the collection of the Libros del Rincón, which nourish the libraries of Mexican public schools from the basic education level. The aleatory review and descriptive analysis of 100 of these literary works has led us to corroborate that digitalization is not only a process of mechanical conversion from analog to digital, but an operation that involves interpretations, decisions, and material interventions that may alter both the presentation of a work and the construction of its meaning. In addition, the interventions that teachers make when digitalizing literary works broaden the reflections on the notions of literature and children’s edition, and generate spaces to rethink the open access. = Desde inicios del 2020, en paralelo al confinamiento sanitario por Covid, en redes sociales han circulado vínculos para descargar títulos pertenecientes a la colección de los Libros del Rincón, los cuales nutren las bibliotecas de las escuelas públicas mexicanas de nivel básico. La revisión aleatoria y el análisis descriptivo de 100 de estas obras nos ha llevado a corroborar que la digitalización no solo se trata de un proceso de conversión mecánica de lo análogo a lo digital, sino de una operación que involucra interpretaciones, decisiones, e intervenciones materiales que pueden alterar tanto la presentación de una obra como la construcción de su significado. Además, las intervenciones que docentes hacen al digitalizar obras literarias amplían las reflexiones en torno a las nociones de literatura y edición infantil, y generan espacios para repensar el acceso abierto.

Abstract Mutations in the Cystic Fibrosis Transmembrane Conductance Regulator gene (CFTR) are responsible for Cystic Fibrosis (CF). The most common CF-causing mutation is the deletion of the 508th amino-acid of CFTR (F508del), leading to dysregulation of the epithelial fluid transport in the airway’s epithelium and the production of a thickened mucus favoring chronic bacterial colonization, sustained inflammation and ultimately respiratory failure. c407 is a bis-phosphinic acid derivative which corrects CFTR dysfunction in epithelial cells carrying the F508del mutation. This study aimed to investigate c407 in vivo activity in the F508del Cftr tm1Eur murine model of CF. Using nasal potential difference measurement, we showed that in vivo administration of c407 by topical, short-term intraperitoneal and long-term subcutaneous route significantly increased the CFTR dependent chloride (Cl−) conductance in F508del Cftr tm1Eur mice. This functional improvement was correlated with a relocalization of F508del-cftr to the apical membrane in nasal epithelial cells. Importantly, c407 long-term administration was well tolerated and in vitro ADME toxicologic studies did not evidence any obvious issue. Our data provide the first in vivo preclinical evidence of c407 efficacy and absence of toxicity after systemic administration for the treatment of Cystic Fibrosis.

Historical photographs are commonly available in landscape archaeology; however, they are rarely used systematically for the maximum benefit in terms of spatial and temporal information. In the framework of the al-ʿŪla Cultural Oasis Project (funded and steered by the French Agency for AlUla Development on behalf of the Royal Commission for AlUla), photographs taken at ground level by the Dominican Fathers Antonin Jaussen and Raphaël Savignac in the early 20th century a.d. were geolocated by identifying mountain peaks in the background and comparing distance ratios (on the photos) with angle ratios (on GIS). These locations were then visited in the field to re-take the photographs. This work demonstrates the value of recontextualized ground-level photographs to improve our knowledge of archaeological landscapes when cross-referenced with data from a systematic archaeological survey. We also propose a reproducible methodology for geolocating historical photographs in similar or other contexts. [ABSTRACT FROM AUTHOR]

Abstract Background Women make up 5% of the European prison population on average. Almost invisible in prison and health research, and suffering the stigma associated with female offending, incarcerated women are often forgotten, and their specific healthcare needs remain much ignored. Combining face-to-face survey interviews and medical chart data, we aim to assess the health status, healthcare needs, and access to preventive medicine of women incarcerated in Switzerland. Results Sixty incarcerated adult women participated in a cross-sectional study to assess their life and incarceration histories, physical and mental health problems, medication, and use of medical services. Eligibility criteria were (a) an incarceration of at least four weeks and (b) the ability to provide written informed consent. Exclusion criteria were psychiatric instability and insufficient language competence. Women’s average age was 34.3 years old (SD = 9.8); 45.0% of them were born in Switzerland, 33.3% in Europe and 15.0% on the African continent. Overall, 61.7% of women self-reported physical or mental health problems and 13.3% indicated they were once diagnosed with a sexually transmitted infection. Further, 78.3% of women were active cigarette smokers; more than one in three women reported alcohol use problems and almost one in two women had used at least one illicit drug in the year before incarceration. Depression and perceived stress scores were above clinical cut-off points for more than half of interviewed women. When asked how they rated their health, 68.3% of women felt it had worsened since incarceration. All but four women had accessed prison medical services; however, our study does not indicate whether women’s use of healthcare was indeed adequate to their needs. Conclusions This study demonstrated incarcerated women’s poor health and health-risk behaviours. Structural changes and gender-responsive health promotion interventions have the potential to improve the health of incarcerated women and help them return to the community in better health.

Context. Off-label, compassionate use of potential drugs against SARS-CoV-2 acute infection could modify their safety profiles. Aims. To evaluate the prevalence and type of adverse drug reactions (ADRs), together with associated risk factors, among Cuban COVID-19 patients treated with chloroquine (CQ), lopinavir/ritonavir (LPV/r), or interferon α2b (IFN α2b), according to the Cuban protocol. Materials and Methods. A prospective descriptive analysis of ADRs was performed on 200 COVID-19 patients who were admitted consecutively to three hospitals in Havana and Pinar del Río from April to July 2020. Information on demographics, ADRs, outcomes, behavioral, and health-related factors was collected using a validated questionnaire and clinical records. Each potential ADR case was assessed for causality based on the WHO-UMC algorithm, concomitant drug influences, and the presence of any drug-drug interactions (DDI). Results. The total frequency of ADRs was 55%, with predominantly gastrointestinal disorders and general symptoms (23% vs 20%). 95.1% of ADRs occurred within 10 days after treatment and 42 potential DDI in 55.5% of patients (61/110) were observed. The prevalence of ADRs was: 44%, 30.4%, and 26.4% for IFN α2b, LPV/r, and CQ, respectively. Sex (odds ratio (OR): 0.40 (95% confidence interval (CI): 0.211–0.742), age (OR: 2.36 (95% CI: 1.02–5.44)), and underlying diseases (OR: 0.12 (95% CI: 0.06–0.23)) were independently associated factors for ADRs (P37 years old, and female sex were associated with ADRs.

In the context of temperature gradient-driven, collisionless trapped-ion modes in magnetic confinement fusion, we perform and analyse numerical simulations to explore the turbulent transport of density and heat, with a focus on the velocity dimension (without compromising the details in the real space). We adopt the bounce-averaged gyrokinetic code TERESA, which focuses on trapped particles dynamics and allows one to study low frequency phenomena at a reduced computational cost. We focus on a time in the simulation where the trapped-ion modes have just saturated in amplitude. We present the structure in velocity space of the fluxes. Both density and heat fluxes present a narrow (temperature-normalized energy width ΔE/T ≈ 0.15) resonance peak with an amplitude high enough for resonant particles to contribute for 90% of the heat flux. We then compare these results obtained from a nonlinear simulation to the prediction from the quasi-linear theory and we find a qualitative agreement throughout the whole energy dimension: from thermal particles to high-energy particles. Quasi-linear theory over-predicts the fluxes by about 15%; however, this reasonable agreement is the result of a compensation between two larger errors of about 50%, both at the resonant energy and at the thermal energy.

UMR 7041 ArScAn supports the establishment of “collective projects” in order to promote cross-fertilization of approaches among its own teams. The collective project “Archéologie du Fait Urbain” (AFU) is one of them. Created in 2018 to provide a place for methodological discussions on urban archaeology projects, its audience now extends well beyond the UMR. AFU organizes one or two study days per year on topics that correspond to problems frequently and increasingly faced by archaeologists working in urban contexts (data recovery from old excavations, surveys of structures in urban contexts, etc.). Since 2020, these topics are deeper explored during “Matinales”: a shorter, but more frequent moment of discussions. The success of these free discussion sessions (without any formal issues or judgments), as evidenced by the institutional as well as the geographical expansion of their audience, shows how much the opportunities for exchange on these questions are sorely lacking, particularly since the disappearance of the “Centre national d’archéologie urbaine de Tours” in 2014. The vitality of the AFU collective project reminds us, on its humble scale, of the urgent need to re-establish an inter-institutional structure to support urban archaeologists in their daily archaeological practice.

We report here the feasibility study of anti-counterfeiting low-cost nanostructured flexible security tags for the tracking of large-scale fabrication products, such as pharmaceuticals or original equipment manufacturers. The fabrication process makes use of the mature nanotechnology called Template Synthesis to shape thin track-etched polymer film into covert laser readable tags, combining random self-organized structures with organized patterns. Techniques are developed to drastically limit the number of fabrication steps and keep fabrication costs low, while opening to numerous adjustment parameters. A dedicated, simple optical setup is presented, to capture speckle images of such tags lightened up by light emitting diodes or laser beams. Speckle images are analyzed in terms of encoding parameters, found here quite numerous to ensure a large coding range of large-scale production batches. We particularly highlight ultra-dark areas in speckle images, where nanowire structures completely inhibit speckle patterns. This unique, high-contrast optical feature addresses these low-cost nanostructured thin films to provide a very promising solution for large-scale security tags.

Se ha hecho común la utilización de los sistemas de gestión del aprendizaje (en inglés Learning Management System) o también llamados plataformas de teleformación. Este entorno como vía para proporcionar conocimientos no sólo es utilizado en Universidades, sino que su uso se ha extendido a otras instituciones como lo es el actual Centro de Formación Ramal para la Informática de DESOFT perteneciente al Ministerio de la Informática y las Comunicaciones (MINCOM). La construcción de conocimientos a lo largo de la vida y el intercambio de experiencias entre personas que realizan trabajos similares requieren de nuevas estrategias docentes. ¿Será suficiente con solo emplear las posibilidades de un sistema de gestión del aprendizaje?, ¿qué sucede cuando concluye la edición de un curso? Este trabajo tiene como objetivo exponer los criterios que al respecto tiene la autora del mismo, quien defiende la vinculación de un sistema de gestión del aprendizaje y una red social como solución a las interrogantes antes formuladas.

Endocrowns are designed to restore endodontically treated teeth with root canal treatment (Rct). Recently, endocrowns were proposed for teeth treated with full pulpotomy (FP). No data exist on in vitro evaluations for this combination. This study aimed to evaluate the mechanical behavior of pulpotomy-treated teeth with endocrowns according to different protocols for preparation design and materials and to assess whether 3D-printed resin simulators could be a reliable alternative for human teeth during in vitro strength tests. One hundred and ten extracted natural molars were randomized into 11 groups according to the type of endodontic treatment, the material used, and the design of peripheric preparation. One hundred and ten resin simulators were separated similarly. The samples were embedded in epoxy resin blocks before being subjected to oblique compressive load until failure. For natural teeth, the variance analysis separated two homogeneous groups, one regrouping the endodontically treated or pulpotomy-treated teeth without coronal restoration and the other one regrouping all the other samples, i.e., the untreated teeth (positive controls) and the treated and restored teeth. The strength resistance was lower for the resin simulators than for natural teeth in all groups. Within the limit of this study, strength resistance is not the most important criterion for choosing the type of material, preparation, or endodontic treatment for endocrowns. Resin simulators are not efficient for in vitro strength studies.

The University of California (UC), Santa Cruz University Library partnered with the campus Writing Program and Office of Institutional Research, Assessment, and Policy Studies to participate in the 2015/16 Association of College and Research Libraries (ACRL) Assessment in Action Program in order to assess the effectiveness of an online library research tutorial for conveying relevant Information Literacy skills to Composition 2 students completing a research assignment. This case study will give an overview of the project outcomes and describe the library’s strategy for using project data and design artifacts to support campus goals for defining Information Literacy learning outcomes across the curriculum.

Presentation at the Third Annual UCSC Assessment Symposium, Santa Cruz, CA. 01/27/2017.

Trapped ion resonance-driven turbulence is investigated in the presence of electron dissipation in a simplified tokamak geometry. A reduced gyrokinetic bounce-averaged model for trapped ions is adopted. Electron dissipation is modeled by a simple phase-shift δ between density and electric potential perturbations. The linear eigenfunction features a peak at the resonant energy, which becomes stronger with increasing electron dissipation. Accurately resolving this narrow peak in numerical simulation of the initial-value problem yields a stringent lower bound on the number of grid points in the energy space. Further, the radial particle flux is investigated in the presence of electron dissipation, including kinetic effects. When the density gradient is higher than the temperature gradient, and the phase-shift is finite but moderate (δ≈0.02), the particle flux peaks at an order-of-magnitude above the gyro-Bohm estimate. Slight particle pinch is observed for δ

Secondary bacterial pneumonia infection is frequent in COVID-19 patients. Nocardia are responsible for opportunistic pulmonary infections especially after steroid treatment. We describe a case of pulmonary nocardiosis following critical COVID-19 pneumonia in an 83-year-old male. Two weeks after initiation of dexamethasone 6 mg/L, the patient developed a new episode of acute dyspnea. The sputum cultures identified Nocardia cyriacigeorgica. In spite of intravenous imipenem and cotrimoxazole treatment the patient died. Physicians should be aware of the possibility of nocardiosis in case of deterioration of respiratory status of severe COVID-19 inpatients and perform Nocardia evaluation. This evaluation requires prolonged culture.

Abstract Background This study investigates the prisoner and prison-level factors associated with healthcare utilization (HCU) and the dynamic effects of previous HCU and health events. We analyze administrative data collected on annual adult prisoner-stay HCU (n = 10,136) including physical and mental chronic disease diagnoses, acute health events, penal circumstances and prison-level factors between 2013 and 2017 in 4 prisons of Canton of Vaud, Switzerland. Utilization of four types of health services: primary, nursing, mental and emergency care; are assessed using multivariate and multi-level negative binomial regressions with fixed/random effects and dynamic models conditional on prior HCU and lagged health events. Results In a prison setting with health screening on detention, removal of financial barriers to care and a nurse-led gatekeeping system, we find that health status, socio-demographic characteristics, penal history, and the prison environment are associated with HCU overtime. After controlling for chronic and past acute illnesses, female prisoners have higher HCU, younger adults more emergencies, and prisoners from Africa, Eastern Europe, and the Americas lower HCU. New prisoners, pretrial detainees or repeat offenders utilize more all types of care. Overcrowding increases primary care but reduces utilization of mental and emergency services. Higher expenditure on medical staff resources is associated with more primary care visits and less emergency visits. The dynamics of HCU across types of care shows persistence over time related to emergency use, previous somatic acute illnesses, and acting out events. There is also evidence of substitution between psychiatric and primary care. Conclusions The prison healthcare system provides an opportunity to diagnose and treat unmet health needs for a marginalized population. Access to psychiatric and chronic disease management during incarceration and prevention of emergency or acute events can reduce future demand for care. Prioritization of high-risk patients and continuity of care inside and outside of prisons may reduce public health pressures in the criminal system. The prison environment and prisoners’ penal circumstances impacts healthcare utilization, suggesting better coordination between the criminal justice and prison health systems is required.

One-shot relation retrieval is the knowledge extraction task that consists in searching in a textual dataset for all occurrences of a relation of interest, named the source relation, characterized by a single example—a relation being a link between a pair of entities in an utterance. Performing this task on large datasets requires an intelligent system to automate the process, for instance when exploring news archives for press review or business intelligence. We propose a framework that leverages the representation learning capabilities of N-way K-shot models for few-shot relation Classification and extends these models to enable one-shot retrieval with a rejection class. At evaluation time, one-shot relation retrieval is performed in a N-way K-shot setting where 1 of the N ways (or relations) is the source relation and the N-1 others are distractors, i.e., relations modeling a rejection class. We benchmark this framework and investigate the influence of the number and the choice of distractors on the standard TACREV and FewRel datasets. Experimental results demonstrate the effectiveness of our approach to address this highly challenging task, however with high variability primarily induced by the type of the source relation. Experiments also highlight a sound strategy for the choice of distractors—a large number of distractors at an intermediate distance from the embedding of the source relation in the latent space learned by the model—, which provides a competing trade-of between recall and precision. This strategy is globally optimal but can however be surpassed on certain source relations by others, depending on the characteristics of the source relation, paving the way for future work. We finally show the substantial benefit of two-shot retrieval over one-shot retrieval, which sheds light on the design of actual intelligent applications leveraging one- or few-shot relation retrieval. [ABSTRACT FROM AUTHOR]

Abstract Background Few studies have evaluated muscle strength in COVID-19 ICU survivors. We aimed to report the incidence of limb and respiratory muscle weakness in COVID-19 ICU survivors. Method We performed a cross sectional study in two ICU tertiary Hospital Settings. COVID-19 ICU survivors were screened and respiratory and limb muscle strength were measured at the time of extubation. An ICU mobility scale was performed at ICU discharge and walking capacity was self-evaluated by patients 30 days after weaning from mechanical ventilation. Results Twenty-three patients were included. Sixteen (69%) had limb muscle weakness and 6 (26%) had overlap limb and respiratory muscle weakness. Amount of physiotherapy was not associated with muscle strength. 44% of patients with limb weakness were unable to walk 100 m 30 days after weaning. Conclusion The large majority of COVID-19 ICU survivors developed ICU acquired limb muscle weakness. 44% of patients with limb weakness still had severely limited function one-month post weaning.

El estudio de los especímenes tipográficos, también conocidos como muestras de letras o catálogos de tipos, permite una clase de investigación de fuentes primarias que combina las facetas histórica, tecnológica, artística y visual y, por extensión, arroja luz sobre otros aspectos de la cultura impresa. Si bien esas fuentes ofrecen una aproximación material al conocimiento del patrimonio gráfico regional, en América Latina se ha investigado poco sobre ellas. El objetivo principal de este trabajo es describir y analizar la estructura y el contenido de dos muestras tipográficas colombianas que fueron elaboradas durante la primera mitad del siglo XX, en el contexto de la enseñanza de artes y oficios en los colegios de los salesianos. El estudio de ambos documentos y su comparación con otras muestras (norteamericanas, europeas, y de dos países de América Latina), así como la revisión de bibliografía especializada, permitirá establecer el origen de algunas de las fundiciones tipográficas utilizadas en Colombia y visualizar una parte de las relaciones de la cultura gráfica colombiana con otras tradiciones tipográficas que a la fecha no se han planteado.

Abstract C407 is a compound that corrects the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein carrying the p.Phe508del (F508del) mutation. We investigated the corrector effect of c407 and its derivatives on F508del-CFTR protein. Molecular docking and dynamics simulations combined with site-directed mutagenesis suggested that c407 stabilizes the F508del-Nucleotide Binding Domain 1 (NBD1) during the co-translational folding process by occupying the position of the p.Phe1068 side chain located at the fourth intracellular loop (ICL4). After CFTR domains assembly, c407 occupies the position of the missing p.Phe508 side chain. C407 alone or in combination with the F508del-CFTR corrector VX-809, increased CFTR activity in cell lines but not in primary respiratory cells carrying the F508del mutation. A structure-based approach resulted in the synthesis of an extended c407 analog G1, designed to improve the interaction with ICL4. G1 significantly increased CFTR activity and response to VX-809 in primary nasal cells of F508del homozygous patients. Our data demonstrate that in-silico optimized c407 derivative G1 acts by a mechanism different from the reference VX-809 corrector and provide insights into its possible molecular mode of action. These results pave the way for novel strategies aiming to optimize the flawed ICL4–NBD1 interface.

Abstract Background Little interest has been paid to expiratory muscle strength, and the impact of expiratory muscle weakness on critical outcomes is not known. Very few studies assessed the relationship between maximal expiratory pressure (MEP) and critical outcomes. The aim of this study was to investigate the relationship between MEP and critical outcomes. Methods This work was a secondary analysis of a prospective, observational study of adult patients who required mechanical ventilation for ≥ 24 h in an 18-bed ICU. MEP was assessed before extubation after a successful, spontaneous breathing trial. The relationships between MEP and extubation failure, and short-term (30 days) mortality, were investigated. Univariate logistic regressions were computed to investigate the relationship between MEP values and critical outcomes. Two multivariate analyses, with and without maximal inspiratory pressure (MIP), both adjusted using principal component analysis, were undertaken. Unadjusted and adjusted ROC curves were computed to compare the respective ability of MEP, MIP and the combination of both measures to discriminate patients with and without extubation failure or premature death. Results One hundred and twenty-four patients were included. Median age was 66 years (IQR 18) and median mechanical ventilation duration was 7 days (IQR 6). Extubation failure rate was 15% (18/124 patients) and the rate for 30-day mortality was 11% (14/124 patient). Higher MEP values were significantly associated with a lower risk of extubation failure in the univariate analysis [OR 0.96 95% CI (0.93–0.98)], but not with short-term mortality. MEP was independently linked with extubation failure when MIP was not included in the multivariate model, but not when it was included, despite limited collinearity between these variables. This study was not able to differentiate the respective abilities of MEP, MIP, and their combination to discriminate patients with extubation failure or premature death (adjusted AUC for the combination of MEP and MIP: 0.825 and 0.650 for extubation failure and premature death, respectively). Conclusions MEP is related to extubation failure. But, the results did not support its use as a substitute for MIP, since the relationship between MEP and critical outcomes was no longer significant when MIP was included. The use of MIP and MEP measurements combined did not reach higher discriminative capacities for critical outcomes that MEP or MIP alone. Trial Registration This study was retrospectively registered at https://clinicaltrials.gov/ct2/show/NCT02363231?cond=NCT02363231&draw=2&rank=1 (NCT02363231) in 13 February 2015

This ACRL Assessment in Action Program project applied an ACRL Information Literacy Standards-based rubric to student research process coversheets and bibliographies. We measured seven Information Literacy outcomes for students who took an online research skills tutorial in lieu of an in-person instruction session.

What is the role of expertise when architectural additions are ad hoc, opportunistic and predicated on what sits below? When development is piecemeal and reliant on the existing built environment for material and form? How do architects negotiate a newfound sense of nostalgia prompted by impending landscape change?

Background Peak oxygen uptake (V˙O2peak) measured by a cardiopulmonary exercise test (CPX) is the gold‐standard for predicting surgical risk in patients with non‐small cell lung cancer (NSCLC). The 3‐minute chair rise test (3CRT) is a simple test requiring minimal resources. This study aimed to determine the ability of 3CRT to predict V˙O2peak in patients with NSCLC. Methods Retrospective data from CPX and 3CRT carried out in 36 patients with NSCLC between March 2018 and February 2019 were included. A multivariate analysis was undertaken to derive a predictive V˙O2peak equation based on performance on the 3CRT. In addition, sensitivity‐specificity analysis was carried out to estimate a threshold 3CRT value for the prediction of V˙O2peak ≥ 15 mL/kg/minute. Results The following equation was obtained: V˙O2peak predicted = (0.04765 × FEV1) ‐ (0.207 59 × BMI) ‐ (0.115 89 × age) + (0.386 09 × vertical distance) + 16.628 69; r2 = 0.75, P