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51. Transoral endoscopic thyroidectomy by a vestibular approach: cadaver simulation experience and ethicolegal issues

Author

Oliva, A, Grassi, S, Minelli, N, Zedda, Massimo, Arena, Vincenzo, Romaniello, N, Dionigi, G, Makay, Ö, De Crea, Carmela, Celik, S, Spagnolo, A Gioacchino, Bellantone, Rocco Domenico Alfonso, Raffaelli, Marco, Zedda, M, Arena, V (ORCID:0000-0002-7562-223X), De Crea, C (ORCID:0000-0002-7303-9657), Bellantone, R (ORCID:0000-0002-0844-3469), Raffaelli, M (ORCID:0000-0002-1259-2491), Oliva, A, Grassi, S, Minelli, N, Zedda, Massimo, Arena, Vincenzo, Romaniello, N, Dionigi, G, Makay, Ö, De Crea, Carmela, Celik, S, Spagnolo, A Gioacchino, Bellantone, Rocco Domenico Alfonso, Raffaelli, Marco, Zedda, M, Arena, V (ORCID:0000-0002-7562-223X), De Crea, C (ORCID:0000-0002-7303-9657), Bellantone, R (ORCID:0000-0002-0844-3469), and Raffaelli, M (ORCID:0000-0002-1259-2491)

Abstract

This article describes the use of transoral endoscopic thyroidectomy by a vestibular approach on cadavers to improve the technical and non-technical skills of surgeons.

Published
2021

52. Claimed medical malpractice in fatal SARS-CoV-2 infections: the importance of combining ante- and post-mortem radiological data and autopsy findings for correct forensic analysis

Author

Filograna, Laura, Manenti, G., Arena, Vincenzo, Dell'Aquila, Marco, Pascali, Vincenzo Lorenzo, Natale, Luigi, Colosimo, Cesare, Grassi, Simone, Floris, R., Oliva, Antonio, Filograna L., Arena V. (ORCID:0000-0002-7562-223X), Dell'Aquila M., Pascali V. L. (ORCID:0000-0001-6520-5224), Natale L. (ORCID:0000-0002-7949-5119), Colosimo C. (ORCID:0000-0003-3800-3648), Grassi S., Oliva A. (ORCID:0000-0001-7120-616X), Filograna, Laura, Manenti, G., Arena, Vincenzo, Dell'Aquila, Marco, Pascali, Vincenzo Lorenzo, Natale, Luigi, Colosimo, Cesare, Grassi, Simone, Floris, R., Oliva, Antonio, Filograna L., Arena V. (ORCID:0000-0002-7562-223X), Dell'Aquila M., Pascali V. L. (ORCID:0000-0001-6520-5224), Natale L. (ORCID:0000-0002-7949-5119), Colosimo C. (ORCID:0000-0003-3800-3648), Grassi S., and Oliva A. (ORCID:0000-0001-7120-616X)

Abstract

We present the case of an elderly woman who died from COVID-19 during the first wave of the pandemic. The physicians in charge of the patient were later accused of medical malpractice resulting in the death of the patient. The article reviews the comprehensive medico-legal investigations into this case that included an analysis of the medical history, clinical imaging, post-mortem imaging, autopsy, histopathology, and microbiology as well as an assessment of the medical knowledge regarding transmission of the SARS-CoV-2 virus and the management of COVID-19 at the time of the patient's death. The investigation resulted in a verdict of not guilty. This case highlights the value of clinical and post-mortem imaging as well as various challenges of medico-legal investigations of COVID-19 related deaths.

Published
2021

53. Future medico-legal implications on obstetrics and gynaecology practice in the SARS-CoV-2 pandemic

Author

Oliva, Antonio, Lazzaro, M. C., Vetrugno, Giuseppe, Foti, F., Grassi, Stefano, Siodambro, C., Pascali, Vincenzo Lorenzo, Scambia, Giovanni, Arduini, Daniela, Oliva A. (ORCID:0000-0001-7120-616X), Vetrugno G. (ORCID:0000-0003-0181-2855), Grassi S., Pascali V. L. (ORCID:0000-0001-6520-5224), Scambia G. (ORCID:0000-0003-2758-1063), Arduini D., Oliva, Antonio, Lazzaro, M. C., Vetrugno, Giuseppe, Foti, F., Grassi, Stefano, Siodambro, C., Pascali, Vincenzo Lorenzo, Scambia, Giovanni, Arduini, Daniela, Oliva A. (ORCID:0000-0001-7120-616X), Vetrugno G. (ORCID:0000-0003-0181-2855), Grassi S., Pascali V. L. (ORCID:0000-0001-6520-5224), Scambia G. (ORCID:0000-0003-2758-1063), and Arduini D.

Abstract

Since February 2020, the Italian National Healthcare System had to mitigate the possibility of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission to vulnerable patients. Healthcare professionals rapidly reviewed their workflow to maintain a safe and high standard treatment, but weak scientific evidences and organizational limits resulted in the adoption of heterogeneous measures. Adherence to screening protocols and follow-up programs pregnant women and oncological patients has not been always guaranteed: this scenario could evolve in an enormous number of medico-legal actions. This context, showing the weakness of the Italian law No. 24/2017, imposes an urgent reorganization of the legal framework to homogenize the judgements to “protect” healthcare professionals involved in this epochal emergency.

Published
2021

54. Transoral endoscopic thyroidectomy by a vestibular approach: Cadaver simulation experience and ethicolegal issues

Author

Oliva, Antonio, Grassi, Simone, Minelli, N., Zedda, Massimo, Arena, Vincenzo, Romaniello, N., Dionigi, G., Makay, O., De Crea, Carmela, Celik, S., Spagnolo, Antonio Gioacchino, Bellantone, Rocco Domenico Alfonso, Raffaelli, Marco, Oliva A. (ORCID:0000-0001-7120-616X), Grassi S., Zedda M., Arena V. (ORCID:0000-0002-7562-223X), De Crea C. (ORCID:0000-0002-7303-9657), Spagnolo A. G. (ORCID:0000-0002-5762-2164), Bellantone R. (ORCID:0000-0002-0844-3469), Raffaelli M. (ORCID:0000-0002-1259-2491), Oliva, Antonio, Grassi, Simone, Minelli, N., Zedda, Massimo, Arena, Vincenzo, Romaniello, N., Dionigi, G., Makay, O., De Crea, Carmela, Celik, S., Spagnolo, Antonio Gioacchino, Bellantone, Rocco Domenico Alfonso, Raffaelli, Marco, Oliva A. (ORCID:0000-0001-7120-616X), Grassi S., Zedda M., Arena V. (ORCID:0000-0002-7562-223X), De Crea C. (ORCID:0000-0002-7303-9657), Spagnolo A. G. (ORCID:0000-0002-5762-2164), Bellantone R. (ORCID:0000-0002-0844-3469), and Raffaelli M. (ORCID:0000-0002-1259-2491)

Abstract

This article describes the use of transoral endoscopic thyroidectomy by a vestibular approach on cadavers to improve the technical and non-technical skills of surgeons.

Published
2021

55. Forensic value of genetic variants associated with anti‐social behavior

Author

Oliva, Antonio, Grassi, S., Zedda, Massimo, Molinari, M., Ferracuti, S., Oliva A. (ORCID:0000-0001-7120-616X), Zedda M., Oliva, Antonio, Grassi, S., Zedda, Massimo, Molinari, M., Ferracuti, S., Oliva A. (ORCID:0000-0001-7120-616X), and Zedda M.

Abstract

Insanity defense is sometimes invoked in criminal cases, and its demonstration is usually based on a multifactorial contribution of behavioural, clinical, and neurological elements. Neuro-radiological evidence of structural alterations in cerebral areas that involve decision‐making and moral reasoning is often accepted as a useful tool in these evaluations. On the other hand, the genetic predisposition to anti‐social behavior is still controversial. In this paper, we describe two cases of violent crimes committed by young carriers of genetic variants associated with personality disorder; both the defendants claimed to be insane at the time of the crime. We discuss these cases and review the scientific literature regarding the relationship between legal incapaci-ty/predisposition to criminal behavior and genetic mutations. In conclusion, despite some genetic variants being able to influence several cognitive processes (like moral judgement and impulse control), there is currently no evidence that carriers of these mutations are, per se, incapable of intentionally committing crimes.

Published
2021

56. Rare variants associated with arrhythmogenic cardiomyopathy: Reclassification five years later

Author

Vallverdu-Prats, M., Alcalde, M., Sarquella-Brugada, G., Cesar, S., Arbelo, E., Fernandez-Falgueras, A., Coll, M., Perez-Serra, A., Puigmule, M., Iglesias, A., Fiol, V., Ferrer-Costa, C., Olmo, B., Pico, F., Lopez, L., Jorda, P., Garcia-alvarez, A., Llano, C. T., Toro, R., Grassi, S., Oliva, Antonio, Brugada, J., Brugada, R., Campuzano, O., Oliva A. (ORCID:0000-0001-7120-616X), Vallverdu-Prats, M., Alcalde, M., Sarquella-Brugada, G., Cesar, S., Arbelo, E., Fernandez-Falgueras, A., Coll, M., Perez-Serra, A., Puigmule, M., Iglesias, A., Fiol, V., Ferrer-Costa, C., Olmo, B., Pico, F., Lopez, L., Jorda, P., Garcia-alvarez, A., Llano, C. T., Toro, R., Grassi, S., Oliva, Antonio, Brugada, J., Brugada, R., Campuzano, O., and Oliva A. (ORCID:0000-0001-7120-616X)

Abstract

Genetic interpretation of rare variants associated with arrhythmogenic cardiomyopathy (ACM) is essential due to their diagnostic implications. New data may relabel previous variant classifications, but how often reanalysis is necessary remains undefined. Five years ago, 39 rare ACM-related variants were identified in patients with features of cardiomyopathy. These variants were classified following the American College of Medical Genetics and Genomics’ guidelines. In the present study, we reevaluated these rare variants including novel available data. All cases carried one rare variant classified as being of ambiguous significance (82.05%) or likely pathogenic (17.95%) in 2016. In our comprehensive reanalysis, the classification of 30.77% of these variants changed, mainly due to updated global frequencies. As in 2016, nowadays most variants were classified as having an uncertain role (64.1%), but the proportion of variants with an uncertain role was significantly decreased (17.95%). The percentage of rare variants classified as potentially del-eterious increased from 17.95% to 23.07%. Moreover, 83.33% of reclassified variants gained cer-tainty. We propose that periodic genetic reanalysis of all rare variants associated with arrhythmo-genic cardiomyopathy should be undertaken at least once every five years. Defining the roles of rare variants may help clinicians obtain a definite diagnosis.

Published
2021

57. Household disinfectant exposure during the COVID-19 pandemic: A retrospective study of the data from an italian poison control center

Author

Soave, P. M., Grassi, S., Oliva, A., Romano, B., Stasio, E. D. I., Dominici, L., Pascali, V., Antonelli, M., Soave P. M., Oliva A. (ORCID:0000-0001-7120-616X), Romano B., Pascali V. (ORCID:0000-0001-6520-5224), Antonelli M. (ORCID:0000-0003-3007-1670), Soave, P. M., Grassi, S., Oliva, A., Romano, B., Stasio, E. D. I., Dominici, L., Pascali, V., Antonelli, M., Soave P. M., Oliva A. (ORCID:0000-0001-7120-616X), Romano B., Pascali V. (ORCID:0000-0001-6520-5224), and Antonelli M. (ORCID:0000-0003-3007-1670)

Abstract

OBJECTIVE: Since the beginning of the COVID-19 pandemic it has been recommended that chemical disinfectants are used to protect surfaces. This study aimed to determine whether the number of exposure calls related to household disinfectants (HD) received between January 30, 2020 to May 18, 2020 varied from the same time period in the previous year. MATERIALS AND METHODS: A retrospective review of the poison control center database from the Fondazione Universitario Policlinico Agostino Gemelli IRCCS, Rome, Italy, was conducted. Calls from Italian citizens, hospitals, and general practitioners received during the same time period in 2019 and 2020 were compared. RESULTS: The center received 1972 exposure calls during the study period. A 5% increase in calls regarding exposure to HDs was noted from 2019 to 2020 (9.8% to 15.2%, p<0.001). The majority of enquiries regarded bleach-containing products, hand sanitizers, ethanol, and hydrogen peroxide. Most calls were received from patients in their homes (n, 259; prevalence, 86%; increase, 107%) and concerned accidental exposure (n, 280; prevalence, 93%; increase, 76%), while cases of intentional exposure decreased (n, 14; prevalence, 5%; decrease, 33%). The main route of exposure was ingestion (n, 170; prevalence, 57%; increase, 45%), but the highest increase was observed in inhalation cases (n, 82; prevalence, 27%; increase, 122%). CONCLUSIONS: As the incidence of enquiries regarding products that can represent an important health hazard, when improperly used, increased in 2020 suggests that the COVID-19 public health messaging on the proper use of HDs should be improved.

Published
2021

58. Postmortem CT and autopsy findings in nine victims of terrorist attack

Author

Oliva, Antonio, Grassi, S., Grassi, V. M., Pinchi, V., Floris, R., Manenti, G., Colosimo, Cesare, Filograna, Laura, Pascali, Vincenzo Lorenzo, Oliva A. (ORCID:0000-0001-7120-616X), Colosimo C. (ORCID:0000-0003-3800-3648), Filograna L., Pascali V. L. (ORCID:0000-0001-6520-5224), Oliva, Antonio, Grassi, S., Grassi, V. M., Pinchi, V., Floris, R., Manenti, G., Colosimo, Cesare, Filograna, Laura, Pascali, Vincenzo Lorenzo, Oliva A. (ORCID:0000-0001-7120-616X), Colosimo C. (ORCID:0000-0003-3800-3648), Filograna L., and Pascali V. L. (ORCID:0000-0001-6520-5224)

Abstract

In a foreign country, a religious terrorist group raided a restaurant, using pipe bombs, sharp-edged weapons, and various types of firearms (handguns, submachine guns, and AK-47 assault rifles) loaded with normal and prohibited bullets to kill foreigner customers, some of whom were Italian tourists. Local pathologists performed forensic autopsies on the bodies, but we were asked to perform additional external examinations, postmortem computed tomography (PMCT) scans, and then a second round of complete autopsies on nine victims (5 females and 4 males). Four victims had slash wounds inflicted by sharp-edged weapons, mostly localized in the head and neck. All but two victims had gunshot wounds. Finally, three casualties had injuries caused by the explosion of improvised explosive devices. In all cases, PMCT was a reliable source of information and provided strategic guide during autopsies, helping identify and describe the injuries and thus reconstruct the events. Therefore, in these cases, we suggest integrating the autopsy findings with the postmortem radiological data.

Published
2021

59. Outsiders sessuali. Le forme collettive della devianza sessuale

Author

Rinaldi C, Grassi S, Rinaldi C, and Grassi S

Subjects
devianze sessuali, copioni sessuali, sessualità, sexual deviation, sexuality
Abstract

Traduzione di : Sexuelle Aussenseiter. Kollektive Formen sexueller Abweichungen collana “rororo sexologie”, Rowohlt, Hamburg

Published
2019

60. IMMAGINARE GLI ITALO-AMERICANI: DALLA SCUOLA DI CHICAGO IN POI. INTRODUZIONE ALLA SEZIONE «CLASSICS»

Author

Rinaldi, C, Grassi, S, Rinaldi, C, and Grassi, S

Subjects
Chicago School, Itan-Americanness, Settore SPS/07 - Sociologia Generale, stereotyper
Abstract

This piece introduces Chiara Mazzucchelli, Anthony Julian Tamburri, and Sabrina Vellucci’s essays on Italian-Americanness, and extracts from Irving L. Child and Harvey Warren Zorbaugh’s sociological studies on marginality and «vice» areas in the US of the early XX century. It frames these distinctive and insightful pieces within the context of identitarian, linguistic, and cultural struggles that make up the archives of Italian migrant communities in the US.In conversation with the five pieces, this introduction aims to inquire into the practices of stigmatisation and reproduction of violence by dominant epistemological and ontological frameworks travelling beyond borders.

Published
2019

63. Are errors in otorhinolaryngology always a sign of medical malpractice? Review of the literature and new perspectives in the sars-cov-2 (covid-19) era

Author

Voultsos, P., Oliva, Antonio, Grassi, S., Palmiero, Debora, Spagnolo, Antonio Gioacchino, Oliva A. (ORCID:0000-0001-7120-616X), Palmiero D., Spagnolo A. G. (ORCID:0000-0002-5762-2164), Voultsos, P., Oliva, Antonio, Grassi, S., Palmiero, Debora, Spagnolo, Antonio Gioacchino, Oliva A. (ORCID:0000-0001-7120-616X), Palmiero D., and Spagnolo A. G. (ORCID:0000-0002-5762-2164)

Abstract

In medical practice, during certain procedures that usually are not regarded highly demand-ing, some skill-based errors, that might not be considered as medical malpractice, may occur. In fact, such errors can be caused by factors beyond the physician’s control.A review of Greek case law regarding medical malpractice in otorhinolaryngology was performed to identify cases of lawsuits that concerned medical errors during routine procedures. The analysis of the cases showed that some medical errors may cause serious complications, even if deviation from the standard of medical care is minimal. Thus, in some cases it may be difficult to make a distinction between preventable and unpreventable complications. Certain medical errors from routine medical procedures might be considered unpreventable and, therefore, classified as almost no-fault errors. A brief commentary regarding opportu-nities to further improve the medical liability system after the SARS-CoV-2 emergency is also given.

Published
2020

64. Liability of Health Care Professionals and Institutions During COVID-19 Pandemic in Italy: Symposium Proceedings and Position Statement

Author

Oliva, Antonio, Caputo, Matteo, Grassi, Simone, Vetrugno, Giuseppe, Marazza, Marco, Ponzanelli, Giulio, Cauda, Roberto, Scambia, Giovanni, Forti, Gabrio, Bellantone, Rocco Domenico Alfonso, Pascali, Vincenzo Lorenzo, Oliva A. (ORCID:0000-0001-7120-616X), Caputo M. (ORCID:0000-0001-6792-9349), Grassi S., Vetrugno G. (ORCID:0000-0003-0181-2855), Marazza M. (ORCID:0000-0002-0765-4774), Ponzanelli G. (ORCID:0000-0002-9970-4301), Cauda R. (ORCID:0000-0002-1498-4229), Scambia G. (ORCID:0000-0003-2758-1063), Forti G. (ORCID:0000-0002-5438-4404), Bellantone R. (ORCID:0000-0002-0844-3469), Pascali V. L. (ORCID:0000-0001-6520-5224), Oliva, Antonio, Caputo, Matteo, Grassi, Simone, Vetrugno, Giuseppe, Marazza, Marco, Ponzanelli, Giulio, Cauda, Roberto, Scambia, Giovanni, Forti, Gabrio, Bellantone, Rocco Domenico Alfonso, Pascali, Vincenzo Lorenzo, Oliva A. (ORCID:0000-0001-7120-616X), Caputo M. (ORCID:0000-0001-6792-9349), Grassi S., Vetrugno G. (ORCID:0000-0003-0181-2855), Marazza M. (ORCID:0000-0002-0765-4774), Ponzanelli G. (ORCID:0000-0002-9970-4301), Cauda R. (ORCID:0000-0002-1498-4229), Scambia G. (ORCID:0000-0003-2758-1063), Forti G. (ORCID:0000-0002-5438-4404), Bellantone R. (ORCID:0000-0002-0844-3469), and Pascali V. L. (ORCID:0000-0001-6520-5224)

Abstract

BACKGROUND: On May 12, 2020, a symposium titled "Liability of healthcare professionals and institutions during COVID-19 pandemic" was held in Italy with the participation of national experts in malpractice law, hospital management, legal medicine, and clinical risk management. The symposium's rationale was the highly likely inflation of criminal and civil proceedings concerning alleged errors committed by health care professionals and decision makers during the COVID-19 pandemic. Its aim was to identify and discuss the main issues of legal and medicolegal interest and thus to find solid solutions in the spirit of preparedness planning. METHODS: There were 5 main points of discussion: (A) how to judge errors committed during the pandemic because of the application of protocols and therapies based on no or weak evidence of efficacy, (B) whether hospital managers can be considered liable for infected health care professionals who were not given adequate personal protective equipment, (C) whether health care professionals and institutions can be considered liable for cases of infected inpatients who claim that the infection was transmitted in a hospital setting, (D) whether health care institutions and hospital managers can be considered liable for the hotspots in long-term care facilities/care homes, and (E) whether health care institutions and hospital managers can be considered liable for the worsening of chronic diseases. RESULTS AND CONCLUSION: Limitation of the liability to the cases of gross negligence (with an explicit definition of this term), a no-fault system with statal indemnities for infected cases, and a rigorous methodology for the expert witnesses were proposed as key interventions for successfully facing future proceedings.

Published
2020

65. Understanding Factors Associated With Psychomotor Subtypes of Delirium in Older Inpatients With Dementia

Author

Morandi, A., Zambon, A., Di Santo, S. G., Mazzone, A., Cherubini, A., Mossello, E., Bo, M., Marengoni, A., Bellelli, G., Rispoli, V., Malara, A., Spadea, F., Di Cello, S., Ceravolo, F., Fabiano, F., Chiaradia, G., Gabriele, A., Lenino, P., Andrea, T., Settembrini, V., Capomolla, D., Citrino, A., Scriva, A., Bruno, I., Secchi, R., De Martino, E., Muccinelli, R., Lupi, G., Paonessa, P., Fabbri, A., Passuti, M. T., Castellari, S., Po, A., Gaggioli, G., Varesi, M., Moneti, P., Capurso, S., Latini, V., Ghidotti, S., Riccardelli, F., Macchi, M., Rigo, R., Claudio, P., Angelo, B., Flavio, C., Benedetta, B., Boffelli, S., Cassinadri, A., Franzoni, S., Spazzini, E., Andretto, D., Tonini, G., Andreani, L., Coralli, M., Balotta, A., Cancelliere, R., Ballardini, G., Simoncelli, M., Mancini, A., Strazzacapa, M., Fabio, S., De Filippi, F., Giudice, C., Dentizzi, C., Azzini, M., Cazzadori, M., Mastroeni, V., Bertassello, P., Claudia Benati, H. S., Nesta, E., Tobaldini, C., Guerini, F., Elena, T., Mombelloni, P., Fontanini, F., Gabriella, L., Pizzorni, C., Oliverio, M., Del Grosso, L. L., Giavedoni, C., Bidoli, G., Mazzei, B., Corsonello, A., Fusco, S., Vena, S., De Vuono, T., Maiuri, G., Luca, F. F., Andrea, A., Giovanni, S., Rossella, N., Castegnaro, E., De Rosa, S., Sechi, R. B., Benvenuti, E., Del Lungo, I., Giardini, S., Giulietti, C., Mauro, D. B., Eleonora, B., Martina, P., Irene, F., Riccardo, B., Federica, S., Ilaria, D. L., Bertoletti, E., D'Amico, F., Caronzolo, F., Grippa, A., Lombardo, G., Pipicella, T., Antonino, S., Francesco, C., Valeria, P. G., Daniela, L., Domenico, C., Giorgio, B., March, A., Nitti, M. T., Felici, A., Pavan, S., Piazzani, F., Lunelli, A., Dimori, S., Margotta, A., Soglia, T., Postacchini, D., Brunelli, R., Santini, S., Francavilla, M., Macchiati, I., Sorvillo, F., Giuli, C., Mecocci, P., Longo, A., Perticone, F., Addesi, D., Rosa, P. C., Bencardino, G., Falbo, T., Grillo, N., Marco, F., Mirella, F., Fanto, F., Isaia, G., Pezzilli, S., Bergamo, D., Furno, E., Rrodhe, S., Lucarini, S., Dijk, B., Dall'Acqua, F., Cappelletto, F., Calvani, D., Becheri, D., Giuseppe, M., Costanza, M., Vito, A., Francesca, B., Magherini, L., Novella, M., Franca, B., Lucia Gambardella, P. M., Valente, C., Ilaria, B., Alice, F., Porrino, P., Ceci, G., Giuliana, B., Michela, T., Eleonora, C., Ettore, E., Camellini, C., Servello, A., Grassi, A., Rozzini, R., Tironi, S., Grassi, M. G., Troisi, E., Carlo, C., Simona Gabriella, D. S., Flaminia, F., Federica, R., Beatrice, P., Sofia, T., Gabutto, A., Quazzo, L., Rosatello, A., Suraci, D., Tagliabue, B., Perrone, C., Ferrara, L., Castagna, A., Tremolada, M. L., Giuseppe, C., Stefano, B., Davide, O., Piano, S., Serviddio, G., Lo Buglio, A., Gurrera, T., Merlo, V., Rovai, C., Cotroneo, A. M., Carlucci, R., Abbaldo, A., Monzani, F., Qasem, A. A., Bini, G., Tafuto, S., Galli, G., Bruni, A. C., Mancuso, G., Calipari, D., Giuseppe Massimiliano, D. L., Bernardini, B., Corsini, C., Michele, C., Sara, D. F., Cagnin, A., Fragiacomo, F., Pompanin, S., Piero, A., Marco, C., Zurlo, A., Guerra, G., Pala, M., Menozzi, L., Gatti, C. D., Magon, S., Roberto, M., Alfredo, D. G., Fabio, F., Ruana, T., Elisa, M., Christian, M., Marco, P., Massimo, G., Di Francesco, V., Faccioli, S., Pellizzari, L., Giorgia, F., Barbagallo, G., Lunardelli, M. L., Martini, E., Ferrari, E., Macchiarulo, M., Corneli, M., Bacci, M., Battaglia, G., Anastasio, L., Lo Storto, M. S., Seresin, C., Simonato, M., Loreggian, M., Cestonaro, F., Durando, M., Latella, R., Mazzoleni, M., Russo, G., Ponte, M., Valchera, A., Salustri, G., Petritola, D., Costa, A., Sinforiani, E., Cotta, M. R., Pizio, R. N., Cester, A., Formilan, M., Pietro, B., Carbone, P., Cazzaniga, I., Appollonio, I., Cereda, D., Stabile, A., Xhani, R., Acampora, R., Tremolizzo, L., Federico, P., Antonio, C., Valerio, P., Cesare, B., Zhirajr, M., Giovanni, V., Maria, A., Mariaelena, S., Bottacchi, E., Bucciantini, E., Di Giovanni, M., Franchi, F., Lucchetti, L., Mariani, C., Grande, G., Rapazzini, P., Marco, M., Romanelli, G., Franco, N., Alessio, M., Nicola, L., Laura, P., Nazario, P., Chiara, G., Soccorso, P., Andrea, S., Luca, B., Francesca, S., Roberto, A., Anna, C., Fugazza, L., Guerrini, C., De Paduanis, G., Iallonardo, L., Palumbo, P., Zuliani, G., Ortolani, B., Capatti, E., Soavi, C., Bianchi, L., Francesconi, D., Miselli, A., Gloria, B., Tommaso, R., Chiara, P., Agata, M. M., Marco, D. A., Luca, M., Gianluca, G., Suardi, T., Zaccarini, C., Manuela, R., Mirra, G., Muti, E., Bottura, R., Gianpaolo, M., Secreto, P., Bisio, E., Cecchettani, M., Naldi, T., Pallavicino, A., Pugliese, M., Iozzo, R. C., Grassi, G., Michele, B., Raffaella, D. O., Fosca, Q. T., Giorgio, G. C., Giovanni, P., Ernesto, C., Mannironi, A., Giorli, E., Oberti, S., Fierro, B., Piccoli, T., Giacalone, F., Mandas, A., Serchisu, L., Costaggiu, D., Pinna, E., Orru, F., Mannai, M., Cordioli, Z., Pelizzari, L., Turcato, E., Arduini, P., Cacace, C., Chiloiro, R., Cimino, R., Ruberto, C., Giovanni, R., Pietro, G., Laura, G., Alberto, C., Carmen, R., Santo, P. D., Andriolli, A., Burattin, G., Rossi, L., Andreolli Antonino, C. G., Tezza, F., Maddalena, P., Laura, S., Crippa, P., Aloisio, P., Di Monda, T., Malighetti, A., Galbassini, G., Salutis, D., Ivaldi, C., Russo, A. M., Bennati, E., Pino, E., Zavarise, G., Pesci, A., Suigo, G., Faverio, P., Andrea, G., Sabrina, P., Zanasi, M., Moniello, G., Rostagno, C., Cartei, A., Polidori, G., Ungar, A., Melis, M. R., Martellini, E., Enrico, M., Monica, T., Antonella, G., Giovanna, L., Migliorini, M., Caramelli, F., Battiston, B., Berardino, M., Cavallo, S., Alessandro, M., Anna, S., Lombardi, B., D'Ippolito, P., Furini, A., Villani, D., Clara, R., Guarneri, M., Paolucci, S., Bassi, A., Coiro, P., De Angelis, D., Morone, G., Venturiero, V., Palleschi, L., Raganato, P., Di Niro, G., Rosa, C. A., Loredana, B., Imoscopi, A., Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, A., Provenzano, G., Mari, D., Romano, F. Y., Rosini, F., Mansi, M., Rossi, S., Geriatria, A. R., Inzaghi, L., Bonini, G., Rossi, P., Potena, A., Lichii, M., Candiani, T., Grimaldi, W., Bertani, E., Alessandra, P., Calogero, P., Pinto, D., Bernardi, R., Nicolino, F., Galetti, C., Gianstefani, A., Giulia, C., Lorenzo, M., Odetti, P., Monacelli, F., Prefumo, M., Fiammetta, M., Canepa, M., Minaglia, C., Paolisso, G., Rizzo, M. R., Prestano, R., Dalise, A. M., Barra, D., Bosco, L. D., Asprinio, V., Dallape, L., Perina, E., Incalzi, R. A., Bartoli, I. R., Pluderi, A., Maina, A., Pecoraro, E., Sciarra, M., Prudente, A., Paola, M., Francesca, M., Manuel, V., Luisella, C., Maria, P. L., Tina, S., Benini, L., Levato, F., Mhiuta, V., Alius, F., Davidoaia, D., Giardini, V., Garancini, M., Bellamoli, C., Terranova, L., Bozzini, C., Tosoni, P., Provoli, E., Cascone, L., Dioli, A., Ferrarin, G., Bucci, A., Bua, G., Fenu, S., Bianchi, G., Casella, S., Romano, V., Maurizio, P., Mascherona, I., Belotti, G., Cavaliere, S., Cuni, E., Merciuc, N., Oberti, R., Veneziani, S., Capoferri, E., De Bernardi, E., Colombo, K., Bravi, M., Nicoletta, N., D'Arcangelo, P., Montenegro, N., Montanari, R., Lamanna, P., Gasperini, B., Isabella, M., Stefania, D., Gaia, A., Filippo, C., Palama, C., Di Emidio, C., Scarpini, E., Arighi, A., Fumagalli, G., Basilico, P., De Amicis Margherita, M., Marta, M., Diletta, M., Granata, A., Ranalli, C., Cammilli, A., Cavallini, M. C., Tricca, M., Natella, D., Gabbani, L., Tesi, F., Martella, L., Imbrici, R., Guerrini, G., Scotuzzi, A. M., Sozzi, F., Valenti, L., Chiarello, A., Monia, M., Pilotto, A., Prete, C., Senesi, B., Meta, A. C., Pendenza, E., Pasqualetti, G., Polini, A., Tognini, S., Ballino, E., Dell'Aquila, G., Gasparrini, P. M., Marotti, E., Migale, M., Scrimieri, A., Falsetti, L., Salvi, A., Toigo, G., Ceschia, G., Rosso, A., Tongiorgi, C., Scarpa, C., De Dominicis, L., Pucci, E., Renzi, S., Cartechini, E., Tomassini, P. F., Del Gobbo, M., Ugenti, F., Romeo, P., Nardelli, A., Lauretani, F., Visioli, S., Montanari, I., Ermini, F., Giordano, A., Pigato, G., Simeone, E., Barbujani, M., Giampieri, M., Amoruso, R., Piccinini, M., Ferrari, C., Gambetti, C., Sfrappini, M., Semeraro, L., Striuli, R., Pelliccioni, G., Marinelli, D., Fabi, K., Rossi, T., Pesallaccia, M., Sabbatini, D., Gobbi, B., Cerqua, R., Tagliani, G., Schlauser, E., Caser, L., Caramello, E., Sandigliano, F., Rosso, G., Ferrari, A., Bendini, C., Luisa, D. M., Casella, M., Prampolini, R., Scevola, M., Vitale, E., Roberto, B., Carlo, F., Sergio, F., Alberto, S., Daniela, Z., Giulia, B., Serena, G., Maugeri, D., Sorace, R., Anzaldi, M., De Gesu, R., Morrone, G., Davolio, F., Fabbo, A., Palmieri, M., Zoli, M., Forti, P., Pirazzoli, L., Fabbri, E., Terenzi, L., Bergolari, F., Wenter, C., Ruffini, I., Insam, M., Abraham, E., Kirchlechner, C., Cucinotta, D., Antonino, L., Basile, G., Grazia, A. M., Parise, P., Boccali, A., Amici, S., Gambacorta, M., Lasagni, A., Lovati, R., Giovinazzo, F., Kimak, E., Zappa, P., Medici, F., Lo Castro, M., Mauro, F., De Luca, A., Sancesario, G., Martorana, A., Scaricamazza, B., Toniolo, S., Di Lorenzo, F., Liguori, C., Lasco, A., Vita, N., Giomi, M., Forte, F., Padovani, A., Rozzini, L., Ceraso, A., Salvatore, C., Cottino, M., Vitali, S., Marelli, E., Tripi, G., Miceli, S., Urso, G., Grioni, G., Vezzadini, G., Misaggi, G., Forlani, C., Avanzi, S., Serena, S., Claudia, C., Marilena, V., Alberto, L., Diego, G., Alessandro, G., Iemolo, F., Sanzaro, E., D'Asta, G., Proietto, M., Carnemolla, A., Razza, G., Spadaro, D., Bertolotti, M., Mussi, C., Neviani, F., Roberto, C., Valentina, G., Linda, M., Francesca, V., Tarozzi, A., Balestri, F., Mannarino, G., Bigolari, M., Natale, A., Grassi, S., Bottaro, C., Stefanelli, S., Bovone, U., Tortorolo, U., Quadri, R., Leone, G., Ponzetto, M., Frasson, P., Annoni, G., Bruni, A., Confalonieri, R., Corsi, M., Moretti, D., Teruzzi, F., Umidi, S., Mazzola, P., Perego, S., Persico, I., Olivieri, G., Bonfanti, A., Hajnalka, S., Galeazzi, M., Massariello, F., Anzuini, A., Caffarra, P., Barocco, F., Spallazzi, M., Paolo, C. G., Simonetta, M., Chioatto, P., Bortolamei, S., Soattin, L., Ruotolo, G., Beneamino, B., Giuseppe, B., Bertazzoli, M., Rota, E., Adobati, A., Scarpa, A., Granziera, S., Zuccher, P., Fabbro, A. D., Zara, D., Lo Nigro, A., Franchetti, L., Toniolo, M., Marcuzzo, C., Rollone, M., Guerriero, F., Sgarlata, C., Masse, A., Zatti, G., Piatti, M., Graci, J., Benati, G., Boschi, F., Biondi, M., Fiumi, N., Erika, T., Locatelli, S. M., Mauri, S., Beretta, M., Margheritis, L., Desideri, G., Liberatore, E., Carucci, A. C., Bonino, P., Caput, M., Antonietti, M. P., Polistena, G., De la Pierre, F., Mari, M., Massignani, P., Tombesi, F., Selvaggio, F., Verbo, B., Bodoni, P., Marchionni, N., Sabatini, T., Mussio, E., Magni, Eugenio, Bianchetti, A., Crucitti, Antonio, Titoldini, G., Cossu, B., Fascendini, S., Licini, C., Tomasoni, A., Calderazzo, M., Daniela, T., Valentina, L., Melotti, R. M., Lilli, A., Buda, S., Adversi, M., Noro, G., Turco, R., Ubezio, M. C., Mantovani, A. R., Viola, M. C., Serrati, C., Pretta, S., Infante, M., Gentile, S., D'Ambrosio, V., Mazzanti, P., Brambilla, C., Sportelli, S., Platto, C., Faraci, B., Quattrocchi, D., Pernigotti, L. M., Pisu, C., Sicuro, F., Zagnoni, P., Ghiglia, S., Mosca, M., Corazzin, I., Deola, M., Biagini, C. A., Bencini, F., Cantini, C., Tonon, E., Pierinelli, S., Onofrj, M., Thomas, A., Filomena, B., Bonanni, L., Gabriella, C., Comi, G., Magnani, G., Santangelo, R., Mazzeo, S., Francesca, C., Giordano, C., Roberto, S. A., Barbieri, C., Giroldi, L., Bandini, F., Masina, M., Malservisi, S., Cicognani, A., Ricca, L., Piccininni, M., Tassinari, T., Brogi, D., Sugo, A., Alessandra, F., Sonia, M., Valerio, V., Andrea, U. C., Enrico, C., Vera, R. F., Assunta, S., Gianmaria, Z., Mauro, P., Barone, A., Razzano, M., Giuseppe, I., Angela, B., Francesco, S., Valeria, D. A., Federico, G., Lucia, P., Antonella, V., Elisabetta, D. C., Cristina, R., Nadia, C., Maria, S., Luciano, A., Chiara, C., Bini, P., Pignata, M., Enrico, B., Maria, V., Giovanni, C., Giorgio, C., Piera, R., Alberto, Z., Ceccon, A., Magrin, L., Marin, S., Barbara, S., Matteo, M., Caterina, P. M., Carla, R., Federica, G., Clara, T., Melania, C., Giampaolo, B., Stefano, G., Valeria, G., Lucia, M., Giovambattista, D., Ester, L., Cecilia, C. A., Maurizio, T., Nadia, B., Grillo, A., Arenare, F., Tonino, M., David, K., Giorgio, V. P., Ubaldo, B., Vincenzo, S., Stefano, M., Marino, F., Busonera Flavio, M. T., Paolo, A., Monica, M., Francesco, B., Roberto, F., Paolo, B., Durantemangoni, E., Testoni, M., Fabio, D. S., Loredana, S., Valeria, S., Fabiano, M., Annabella, D. G., Salvatore, D. C., Greco, A., Grazia, D. O., Daniele, S., Gianluca, R., Renzo, G., Sergio, M., Morena, B., Vitali, M., Marina, P., Paolo, D. C., Cristina, S., Orlandini, F., La Regina, M., Desiree, A., Mario, B., Paola, P., Padulo, F., Cristina, M., Dario, R., Giancarla, M., Guido, R., Elena, M., Marileda, N., Igor, B., Nicole, B., Elena, R., Paolillo, C., Riccardi, A., Claudia, B., Barbara, R., Silvia, V., Oliver, B., Mauro, C., Eleonora, M., Giuseppe, P., Rosaria, T., Maria, C., Davide, D. A., Stefania, C., Massimo, P., Luca, S., Martina, D. F., Paola, V., Lia, S., Sandro, C., Valentina, D. S., Erminia, B., Paola, C., Romina, R., Minisola, S., Luciano, C., Pasquale, A., Ilaria, L., Guglielmo, S., Marco, E., Sara, R., Paola, A., Claudio, A., Francesco, R., Alessandro, C., Simona, M., Lara, F., Paola, R., Simonetta, C., Antonella, C., Generoso, U., Fernando, G., Giuliano, C., Emanuela, S., Mariolina, S., Alessandro, D., Giulia, L., Famularo, S., Sandini, M., Pinotti, E., Gianotti, L., Antonella, B., Giulia, P., Sante, G., Rossi, A., Rubele, S., Sant, S., Marco, V., Danila, C., Fabio, R., Bandirali, M. P., Nicoletta, C., Laura, B., Paolo, T., Luciano, T., Leonello, A., Margherita, S., Stefania, D. N., Pierluigi, D. S., Laura, R., Fabiana, T., Giovanna, C., Antonino, A., Felice, C., Danilo, F., Giovanna, D. B., Francesco, L., Salini, S., Angela, B. M., Giorgetta, C., Giovanni, G., Gerardo, B., Silvio, R., Letizia, S., Davide, B., Rosaria, R. M., Maria, D. A., Raffaele, P., Palmieri, V. O., Palasciano, G., Belfiore, A., Portincasa, P., Carlo, S., Alessia, D., Valiani, V., Carolina, B., Tiziana, C., Paola, T., Ugo, P., Giacomo, P., Castellano, M., Anna, G., Elisa, C., Federica, C., Antonietta, C. M., Luigi, M., Fabio, L., Salvatore, B., Gelosa, G., Viviana, A. T., Piras, V., Andrea, C., Alessandra, B., Coen, D., Magliola, R., Milanesio, D., Muzzulini, C. L., Paolo, F., Marinella, T., Sofia, C. M., Marta, B., Siano, P., Capo, G., Napoletano, R., Cecilia, P., Mancini, C., Del Buono, C., De Bartolomeo, G., Addolorata, M., Carmen, C., Giovanni, V. A., Moschettini, G., Franco, M., Daniela, R., D'Amico, G., Mirella, P., Endrizzi, C., Trotta, L., Ciarambino, T., Orazio, Z., Emanuela, T., Marta, S., Thomas, F., Giacomo, T., Ignazio, D. F., Andrea, B., Giuseppe, O., Emanuela, F., Serena, A., Elena, D. I., Serena, B., Erika, N., Roberto, S., Elena, S., Manuela, P., Francesca, A., Angelo, T., Magni E. (ORCID:0000-0002-2235-2280), Crucitti A. (ORCID:0000-0003-3496-4185), Morandi, A., Zambon, A., Di Santo, S. G., Mazzone, A., Cherubini, A., Mossello, E., Bo, M., Marengoni, A., Bellelli, G., Rispoli, V., Malara, A., Spadea, F., Di Cello, S., Ceravolo, F., Fabiano, F., Chiaradia, G., Gabriele, A., Lenino, P., Andrea, T., Settembrini, V., Capomolla, D., Citrino, A., Scriva, A., Bruno, I., Secchi, R., De Martino, E., Muccinelli, R., Lupi, G., Paonessa, P., Fabbri, A., Passuti, M. T., Castellari, S., Po, A., Gaggioli, G., Varesi, M., Moneti, P., Capurso, S., Latini, V., Ghidotti, S., Riccardelli, F., Macchi, M., Rigo, R., Claudio, P., Angelo, B., Flavio, C., Benedetta, B., Boffelli, S., Cassinadri, A., Franzoni, S., Spazzini, E., Andretto, D., Tonini, G., Andreani, L., Coralli, M., Balotta, A., Cancelliere, R., Ballardini, G., Simoncelli, M., Mancini, A., Strazzacapa, M., Fabio, S., De Filippi, F., Giudice, C., Dentizzi, C., Azzini, M., Cazzadori, M., Mastroeni, V., Bertassello, P., Claudia Benati, H. S., Nesta, E., Tobaldini, C., Guerini, F., Elena, T., Mombelloni, P., Fontanini, F., Gabriella, L., Pizzorni, C., Oliverio, M., Del Grosso, L. L., Giavedoni, C., Bidoli, G., Mazzei, B., Corsonello, A., Fusco, S., Vena, S., De Vuono, T., Maiuri, G., Luca, F. F., Andrea, A., Giovanni, S., Rossella, N., Castegnaro, E., De Rosa, S., Sechi, R. B., Benvenuti, E., Del Lungo, I., Giardini, S., Giulietti, C., Mauro, D. B., Eleonora, B., Martina, P., Irene, F., Riccardo, B., Federica, S., Ilaria, D. L., Bertoletti, E., D'Amico, F., Caronzolo, F., Grippa, A., Lombardo, G., Pipicella, T., Antonino, S., Francesco, C., Valeria, P. G., Daniela, L., Domenico, C., Giorgio, B., March, A., Nitti, M. T., Felici, A., Pavan, S., Piazzani, F., Lunelli, A., Dimori, S., Margotta, A., Soglia, T., Postacchini, D., Brunelli, R., Santini, S., Francavilla, M., Macchiati, I., Sorvillo, F., Giuli, C., Mecocci, P., Longo, A., Perticone, F., Addesi, D., Rosa, P. C., Bencardino, G., Falbo, T., Grillo, N., Marco, F., Mirella, F., Fanto, F., Isaia, G., Pezzilli, S., Bergamo, D., Furno, E., Rrodhe, S., Lucarini, S., Dijk, B., Dall'Acqua, F., Cappelletto, F., Calvani, D., Becheri, D., Giuseppe, M., Costanza, M., Vito, A., Francesca, B., Magherini, L., Novella, M., Franca, B., Lucia Gambardella, P. M., Valente, C., Ilaria, B., Alice, F., Porrino, P., Ceci, G., Giuliana, B., Michela, T., Eleonora, C., Ettore, E., Camellini, C., Servello, A., Grassi, A., Rozzini, R., Tironi, S., Grassi, M. G., Troisi, E., Carlo, C., Simona Gabriella, D. S., Flaminia, F., Federica, R., Beatrice, P., Sofia, T., Gabutto, A., Quazzo, L., Rosatello, A., Suraci, D., Tagliabue, B., Perrone, C., Ferrara, L., Castagna, A., Tremolada, M. L., Giuseppe, C., Stefano, B., Davide, O., Piano, S., Serviddio, G., Lo Buglio, A., Gurrera, T., Merlo, V., Rovai, C., Cotroneo, A. M., Carlucci, R., Abbaldo, A., Monzani, F., Qasem, A. A., Bini, G., Tafuto, S., Galli, G., Bruni, A. C., Mancuso, G., Calipari, D., Giuseppe Massimiliano, D. L., Bernardini, B., Corsini, C., Michele, C., Sara, D. F., Cagnin, A., Fragiacomo, F., Pompanin, S., Piero, A., Marco, C., Zurlo, A., Guerra, G., Pala, M., Menozzi, L., Gatti, C. D., Magon, S., Roberto, M., Alfredo, D. G., Fabio, F., Ruana, T., Elisa, M., Christian, M., Marco, P., Massimo, G., Di Francesco, V., Faccioli, S., Pellizzari, L., Giorgia, F., Barbagallo, G., Lunardelli, M. L., Martini, E., Ferrari, E., Macchiarulo, M., Corneli, M., Bacci, M., Battaglia, G., Anastasio, L., Lo Storto, M. S., Seresin, C., Simonato, M., Loreggian, M., Cestonaro, F., Durando, M., Latella, R., Mazzoleni, M., Russo, G., Ponte, M., Valchera, A., Salustri, G., Petritola, D., Costa, A., Sinforiani, E., Cotta, M. R., Pizio, R. N., Cester, A., Formilan, M., Pietro, B., Carbone, P., Cazzaniga, I., Appollonio, I., Cereda, D., Stabile, A., Xhani, R., Acampora, R., Tremolizzo, L., Federico, P., Antonio, C., Valerio, P., Cesare, B., Zhirajr, M., Giovanni, V., Maria, A., Mariaelena, S., Bottacchi, E., Bucciantini, E., Di Giovanni, M., Franchi, F., Lucchetti, L., Mariani, C., Grande, G., Rapazzini, P., Marco, M., Romanelli, G., Franco, N., Alessio, M., Nicola, L., Laura, P., Nazario, P., Chiara, G., Soccorso, P., Andrea, S., Luca, B., Francesca, S., Roberto, A., Anna, C., Fugazza, L., Guerrini, C., De Paduanis, G., Iallonardo, L., Palumbo, P., Zuliani, G., Ortolani, B., Capatti, E., Soavi, C., Bianchi, L., Francesconi, D., Miselli, A., Gloria, B., Tommaso, R., Chiara, P., Agata, M. M., Marco, D. A., Luca, M., Gianluca, G., Suardi, T., Zaccarini, C., Manuela, R., Mirra, G., Muti, E., Bottura, R., Gianpaolo, M., Secreto, P., Bisio, E., Cecchettani, M., Naldi, T., Pallavicino, A., Pugliese, M., Iozzo, R. C., Grassi, G., Michele, B., Raffaella, D. O., Fosca, Q. T., Giorgio, G. C., Giovanni, P., Ernesto, C., Mannironi, A., Giorli, E., Oberti, S., Fierro, B., Piccoli, T., Giacalone, F., Mandas, A., Serchisu, L., Costaggiu, D., Pinna, E., Orru, F., Mannai, M., Cordioli, Z., Pelizzari, L., Turcato, E., Arduini, P., Cacace, C., Chiloiro, R., Cimino, R., Ruberto, C., Giovanni, R., Pietro, G., Laura, G., Alberto, C., Carmen, R., Santo, P. D., Andriolli, A., Burattin, G., Rossi, L., Andreolli Antonino, C. G., Tezza, F., Maddalena, P., Laura, S., Crippa, P., Aloisio, P., Di Monda, T., Malighetti, A., Galbassini, G., Salutis, D., Ivaldi, C., Russo, A. M., Bennati, E., Pino, E., Zavarise, G., Pesci, A., Suigo, G., Faverio, P., Andrea, G., Sabrina, P., Zanasi, M., Moniello, G., Rostagno, C., Cartei, A., Polidori, G., Ungar, A., Melis, M. R., Martellini, E., Enrico, M., Monica, T., Antonella, G., Giovanna, L., Migliorini, M., Caramelli, F., Battiston, B., Berardino, M., Cavallo, S., Alessandro, M., Anna, S., Lombardi, B., D'Ippolito, P., Furini, A., Villani, D., Clara, R., Guarneri, M., Paolucci, S., Bassi, A., Coiro, P., De Angelis, D., Morone, G., Venturiero, V., Palleschi, L., Raganato, P., Di Niro, G., Rosa, C. A., Loredana, B., Imoscopi, A., Tibaldi, V., Bottignole G, G., Calvi, E., Clementi, C., Zanocchi, M., Agosta, L., Nortarelli, A., Provenzano, G., Mari, D., Romano, F. Y., Rosini, F., Mansi, M., Rossi, S., Geriatria, A. R., Inzaghi, L., Bonini, G., Rossi, P., Potena, A., Lichii, M., Candiani, T., Grimaldi, W., Bertani, E., Alessandra, P., Calogero, P., Pinto, D., Bernardi, R., Nicolino, F., Galetti, C., Gianstefani, A., Giulia, C., Lorenzo, M., Odetti, P., Monacelli, F., Prefumo, M., Fiammetta, M., Canepa, M., Minaglia, C., Paolisso, G., Rizzo, M. R., Prestano, R., Dalise, A. M., Barra, D., Bosco, L. D., Asprinio, V., Dallape, L., Perina, E., Incalzi, R. A., Bartoli, I. R., Pluderi, A., Maina, A., Pecoraro, E., Sciarra, M., Prudente, A., Paola, M., Francesca, M., Manuel, V., Luisella, C., Maria, P. L., Tina, S., Benini, L., Levato, F., Mhiuta, V., Alius, F., Davidoaia, D., Giardini, V., Garancini, M., Bellamoli, C., Terranova, L., Bozzini, C., Tosoni, P., Provoli, E., Cascone, L., Dioli, A., Ferrarin, G., Bucci, A., Bua, G., Fenu, S., Bianchi, G., Casella, S., Romano, V., Maurizio, P., Mascherona, I., Belotti, G., Cavaliere, S., Cuni, E., Merciuc, N., Oberti, R., Veneziani, S., Capoferri, E., De Bernardi, E., Colombo, K., Bravi, M., Nicoletta, N., D'Arcangelo, P., Montenegro, N., Montanari, R., Lamanna, P., Gasperini, B., Isabella, M., Stefania, D., Gaia, A., Filippo, C., Palama, C., Di Emidio, C., Scarpini, E., Arighi, A., Fumagalli, G., Basilico, P., De Amicis Margherita, M., Marta, M., Diletta, M., Granata, A., Ranalli, C., Cammilli, A., Cavallini, M. C., Tricca, M., Natella, D., Gabbani, L., Tesi, F., Martella, L., Imbrici, R., Guerrini, G., Scotuzzi, A. M., Sozzi, F., Valenti, L., Chiarello, A., Monia, M., Pilotto, A., Prete, C., Senesi, B., Meta, A. C., Pendenza, E., Pasqualetti, G., Polini, A., Tognini, S., Ballino, E., Dell'Aquila, G., Gasparrini, P. M., Marotti, E., Migale, M., Scrimieri, A., Falsetti, L., Salvi, A., Toigo, G., Ceschia, G., Rosso, A., Tongiorgi, C., Scarpa, C., De Dominicis, L., Pucci, E., Renzi, S., Cartechini, E., Tomassini, P. F., Del Gobbo, M., Ugenti, F., Romeo, P., Nardelli, A., Lauretani, F., Visioli, S., Montanari, I., Ermini, F., Giordano, A., Pigato, G., Simeone, E., Barbujani, M., Giampieri, M., Amoruso, R., Piccinini, M., Ferrari, C., Gambetti, C., Sfrappini, M., Semeraro, L., Striuli, R., Pelliccioni, G., Marinelli, D., Fabi, K., Rossi, T., Pesallaccia, M., Sabbatini, D., Gobbi, B., Cerqua, R., Tagliani, G., Schlauser, E., Caser, L., Caramello, E., Sandigliano, F., Rosso, G., Ferrari, A., Bendini, C., Luisa, D. M., Casella, M., Prampolini, R., Scevola, M., Vitale, E., Roberto, B., Carlo, F., Sergio, F., Alberto, S., Daniela, Z., Giulia, B., Serena, G., Maugeri, D., Sorace, R., Anzaldi, M., De Gesu, R., Morrone, G., Davolio, F., Fabbo, A., Palmieri, M., Zoli, M., Forti, P., Pirazzoli, L., Fabbri, E., Terenzi, L., Bergolari, F., Wenter, C., Ruffini, I., Insam, M., Abraham, E., Kirchlechner, C., Cucinotta, D., Antonino, L., Basile, G., Grazia, A. M., Parise, P., Boccali, A., Amici, S., Gambacorta, M., Lasagni, A., Lovati, R., Giovinazzo, F., Kimak, E., Zappa, P., Medici, F., Lo Castro, M., Mauro, F., De Luca, A., Sancesario, G., Martorana, A., Scaricamazza, B., Toniolo, S., Di Lorenzo, F., Liguori, C., Lasco, A., Vita, N., Giomi, M., Forte, F., Padovani, A., Rozzini, L., Ceraso, A., Salvatore, C., Cottino, M., Vitali, S., Marelli, E., Tripi, G., Miceli, S., Urso, G., Grioni, G., Vezzadini, G., Misaggi, G., Forlani, C., Avanzi, S., Serena, S., Claudia, C., Marilena, V., Alberto, L., Diego, G., Alessandro, G., Iemolo, F., Sanzaro, E., D'Asta, G., Proietto, M., Carnemolla, A., Razza, G., Spadaro, D., Bertolotti, M., Mussi, C., Neviani, F., Roberto, C., Valentina, G., Linda, M., Francesca, V., Tarozzi, A., Balestri, F., Mannarino, G., Bigolari, M., Natale, A., Grassi, S., Bottaro, C., Stefanelli, S., Bovone, U., Tortorolo, U., Quadri, R., Leone, G., Ponzetto, M., Frasson, P., Annoni, G., Bruni, A., Confalonieri, R., Corsi, M., Moretti, D., Teruzzi, F., Umidi, S., Mazzola, P., Perego, S., Persico, I., Olivieri, G., Bonfanti, A., Hajnalka, S., Galeazzi, M., Massariello, F., Anzuini, A., Caffarra, P., Barocco, F., Spallazzi, M., Paolo, C. G., Simonetta, M., Chioatto, P., Bortolamei, S., Soattin, L., Ruotolo, G., Beneamino, B., Giuseppe, B., Bertazzoli, M., Rota, E., Adobati, A., Scarpa, A., Granziera, S., Zuccher, P., Fabbro, A. D., Zara, D., Lo Nigro, A., Franchetti, L., Toniolo, M., Marcuzzo, C., Rollone, M., Guerriero, F., Sgarlata, C., Masse, A., Zatti, G., Piatti, M., Graci, J., Benati, G., Boschi, F., Biondi, M., Fiumi, N., Erika, T., Locatelli, S. M., Mauri, S., Beretta, M., Margheritis, L., Desideri, G., Liberatore, E., Carucci, A. C., Bonino, P., Caput, M., Antonietti, M. P., Polistena, G., De la Pierre, F., Mari, M., Massignani, P., Tombesi, F., Selvaggio, F., Verbo, B., Bodoni, P., Marchionni, N., Sabatini, T., Mussio, E., Magni, Eugenio, Bianchetti, A., Crucitti, Antonio, Titoldini, G., Cossu, B., Fascendini, S., Licini, C., Tomasoni, A., Calderazzo, M., Daniela, T., Valentina, L., Melotti, R. M., Lilli, A., Buda, S., Adversi, M., Noro, G., Turco, R., Ubezio, M. C., Mantovani, A. R., Viola, M. C., Serrati, C., Pretta, S., Infante, M., Gentile, S., D'Ambrosio, V., Mazzanti, P., Brambilla, C., Sportelli, S., Platto, C., Faraci, B., Quattrocchi, D., Pernigotti, L. M., Pisu, C., Sicuro, F., Zagnoni, P., Ghiglia, S., Mosca, M., Corazzin, I., Deola, M., Biagini, C. A., Bencini, F., Cantini, C., Tonon, E., Pierinelli, S., Onofrj, M., Thomas, A., Filomena, B., Bonanni, L., Gabriella, C., Comi, G., Magnani, G., Santangelo, R., Mazzeo, S., Francesca, C., Giordano, C., Roberto, S. A., Barbieri, C., Giroldi, L., Bandini, F., Masina, M., Malservisi, S., Cicognani, A., Ricca, L., Piccininni, M., Tassinari, T., Brogi, D., Sugo, A., Alessandra, F., Sonia, M., Valerio, V., Andrea, U. C., Enrico, C., Vera, R. F., Assunta, S., Gianmaria, Z., Mauro, P., Barone, A., Razzano, M., Giuseppe, I., Angela, B., Francesco, S., Valeria, D. A., Federico, G., Lucia, P., Antonella, V., Elisabetta, D. C., Cristina, R., Nadia, C., Maria, S., Luciano, A., Chiara, C., Bini, P., Pignata, M., Enrico, B., Maria, V., Giovanni, C., Giorgio, C., Piera, R., Alberto, Z., Ceccon, A., Magrin, L., Marin, S., Barbara, S., Matteo, M., Caterina, P. M., Carla, R., Federica, G., Clara, T., Melania, C., Giampaolo, B., Stefano, G., Valeria, G., Lucia, M., Giovambattista, D., Ester, L., Cecilia, C. A., Maurizio, T., Nadia, B., Grillo, A., Arenare, F., Tonino, M., David, K., Giorgio, V. P., Ubaldo, B., Vincenzo, S., Stefano, M., Marino, F., Busonera Flavio, M. T., Paolo, A., Monica, M., Francesco, B., Roberto, F., Paolo, B., Durantemangoni, E., Testoni, M., Fabio, D. S., Loredana, S., Valeria, S., Fabiano, M., Annabella, D. G., Salvatore, D. C., Greco, A., Grazia, D. O., Daniele, S., Gianluca, R., Renzo, G., Sergio, M., Morena, B., Vitali, M., Marina, P., Paolo, D. C., Cristina, S., Orlandini, F., La Regina, M., Desiree, A., Mario, B., Paola, P., Padulo, F., Cristina, M., Dario, R., Giancarla, M., Guido, R., Elena, M., Marileda, N., Igor, B., Nicole, B., Elena, R., Paolillo, C., Riccardi, A., Claudia, B., Barbara, R., Silvia, V., Oliver, B., Mauro, C., Eleonora, M., Giuseppe, P., Rosaria, T., Maria, C., Davide, D. A., Stefania, C., Massimo, P., Luca, S., Martina, D. F., Paola, V., Lia, S., Sandro, C., Valentina, D. S., Erminia, B., Paola, C., Romina, R., Minisola, S., Luciano, C., Pasquale, A., Ilaria, L., Guglielmo, S., Marco, E., Sara, R., Paola, A., Claudio, A., Francesco, R., Alessandro, C., Simona, M., Lara, F., Paola, R., Simonetta, C., Antonella, C., Generoso, U., Fernando, G., Giuliano, C., Emanuela, S., Mariolina, S., Alessandro, D., Giulia, L., Famularo, S., Sandini, M., Pinotti, E., Gianotti, L., Antonella, B., Giulia, P., Sante, G., Rossi, A., Rubele, S., Sant, S., Marco, V., Danila, C., Fabio, R., Bandirali, M. P., Nicoletta, C., Laura, B., Paolo, T., Luciano, T., Leonello, A., Margherita, S., Stefania, D. N., Pierluigi, D. S., Laura, R., Fabiana, T., Giovanna, C., Antonino, A., Felice, C., Danilo, F., Giovanna, D. B., Francesco, L., Salini, S., Angela, B. M., Giorgetta, C., Giovanni, G., Gerardo, B., Silvio, R., Letizia, S., Davide, B., Rosaria, R. M., Maria, D. A., Raffaele, P., Palmieri, V. O., Palasciano, G., Belfiore, A., Portincasa, P., Carlo, S., Alessia, D., Valiani, V., Carolina, B., Tiziana, C., Paola, T., Ugo, P., Giacomo, P., Castellano, M., Anna, G., Elisa, C., Federica, C., Antonietta, C. M., Luigi, M., Fabio, L., Salvatore, B., Gelosa, G., Viviana, A. T., Piras, V., Andrea, C., Alessandra, B., Coen, D., Magliola, R., Milanesio, D., Muzzulini, C. L., Paolo, F., Marinella, T., Sofia, C. M., Marta, B., Siano, P., Capo, G., Napoletano, R., Cecilia, P., Mancini, C., Del Buono, C., De Bartolomeo, G., Addolorata, M., Carmen, C., Giovanni, V. A., Moschettini, G., Franco, M., Daniela, R., D'Amico, G., Mirella, P., Endrizzi, C., Trotta, L., Ciarambino, T., Orazio, Z., Emanuela, T., Marta, S., Thomas, F., Giacomo, T., Ignazio, D. F., Andrea, B., Giuseppe, O., Emanuela, F., Serena, A., Elena, D. I., Serena, B., Erika, N., Roberto, S., Elena, S., Manuela, P., Francesca, A., Angelo, T., Magni E. (ORCID:0000-0002-2235-2280), and Crucitti A. (ORCID:0000-0003-3496-4185)

Abstract

Objectives: Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments. Design: This is a cross-sectional study nested in the “Delirium Day” study, a nationwide Italian point-prevalence study. Setting and Participants: Older patients admitted to 205 acute and 92 rehabilitation hospital wards. Measures: Delirium was evaluated with the 4-AT and the motor subtypes with the Delirium Motor Subtype Scale. Dementia was defined by the presence of a documented diagnosis in the medical records and/or prescription of acetylcholinesterase inhibitors or memantine prior to admission. Results: Of the 1057 patients with dementia, 35% had delirium, with 25.6% hyperactive, 33.1% hypoactive, 34.5% mixed, and 6.7% nonmotor subtype. There were higher odds of having venous catheters in the hypoactive (OR 1.82, 95% CI 1.18-2.81) and mixed type of delirium (OR 2.23, CI 1.43-3.46), whereas higher odds of urinary catheters in the hypoactive (OR 2.91, CI 1.92-4.39), hyperactive (OR 1.99, CI 1.23-3.21), and mixed types of delirium (OR 2.05, CI 1.36-3.07). We found higher odds of antipsychotics both in the hyperactive (OR 2.87, CI 1.81-4.54) and mixed subtype (OR 1.84, CI 1.24-2.75), whereas higher odds of antibiotics was present only in the mixed subtype (OR 1.91, CI 1.26-2.87). Conclusions and Implications: In patients with dementia, the mixed delirium subtype is the most prevalent followed by the hypoactive, hyperactive, and nonmotor subtype. Motor subtypes of delirium may be triggered by clinical factors, including the use of venous and urinary catheters, and the use of antipsychotics. Future studies are necessary to provide further insights on the possible pathophysiology of delirium in patients with dementia and to address the optimization of the management of potential risk factors.

Published
2020

66. Sudden Cardiac Death and Copy Number Variants: What Do We Know after 10 Years of Genetic Analysis?

Author

Mates, J., Mademont-Soler, I., Fernandez-Falgueras, A., Sarquella-Brugada, G., Cesar, S., Arbelo, E., Garcia-Alvarez, A., Jorda, P., Toro, R., Coll, M., Fiol, V., Iglesias, A., Perez-Serra, A., Olmo, B. D., Alcalde, M., Puigmule, M., Pico, F., Lopez, L., Ferrer, C., Tiron, C., Grassi, S., Oliva, Antonio, Brugada, J., Brugada, R., Campuzano, O., Oliva A. (ORCID:0000-0001-7120-616X), Mates, J., Mademont-Soler, I., Fernandez-Falgueras, A., Sarquella-Brugada, G., Cesar, S., Arbelo, E., Garcia-Alvarez, A., Jorda, P., Toro, R., Coll, M., Fiol, V., Iglesias, A., Perez-Serra, A., Olmo, B. D., Alcalde, M., Puigmule, M., Pico, F., Lopez, L., Ferrer, C., Tiron, C., Grassi, S., Oliva, Antonio, Brugada, J., Brugada, R., Campuzano, O., and Oliva A. (ORCID:0000-0001-7120-616X)

Abstract

Over the last ten years, analysis of copy number variants has increasingly been applied to the study of arrhythmogenic pathologies associated with sudden death, mainly due to significant advances in the field of massive genetic sequencing. Nevertheless, few published reports have focused on the prevalence of copy number variants associated with sudden cardiac death. As a result, the frequency of these genetic alterations in arrhythmogenic diseases as well as their genetic interpretation and clinical translation has not been established. This review summarizes the current available data concerning copy number variants in sudden cardiac death-related diseases.

Published
2020

67. Reanalysis and reclassification of rare genetic variants associated with inherited arrhythmogenic syndromes

Author

Campuzano, O., Sarquella-Brugada, G., Fernandez-Falgueras, A., Coll, M., Iglesias, A., Ferrer-Costa, C., Cesar, S., Arbelo, E., Garcia-Alvarez, A., Jorda, P., Toro, R., Tiron de Llano, C., Grassi, S., Oliva, Antonio, Brugada, J., Brugada, R., Oliva A. (ORCID:0000-0001-7120-616X), Campuzano, O., Sarquella-Brugada, G., Fernandez-Falgueras, A., Coll, M., Iglesias, A., Ferrer-Costa, C., Cesar, S., Arbelo, E., Garcia-Alvarez, A., Jorda, P., Toro, R., Tiron de Llano, C., Grassi, S., Oliva, Antonio, Brugada, J., Brugada, R., and Oliva A. (ORCID:0000-0001-7120-616X)

Abstract

Background: Accurate interpretation of rare genetic variants is a challenge for clinical translation. Updates in recommendations for rare variant classification require the reanalysis and reclassification. We aim to perform an exhaustive re-analysis of rare variants associated with inherited arrhythmogenic syndromes, which were classified ten years ago, to determine whether their classification aligns with current standards and research findings. Methods: In 2010, the rare variants identified through genetic analysis were classified following recommendations available at that time. Nowadays, the same variants have been reclassified following current American College of Medical Genetics and Genomics recommendations. Findings: Our cohort included 104 cases diagnosed with inherited arrhythmogenic syndromes and 17 post-mortem cases in which inherited arrhythmogenic syndromes was cause of death. 71.87% of variants change their classification. While 65.62% of variants were classified as likely pathogenic in 2010, after reanalysis, only 17.96% remain as likely pathogenic. In 2010, 18.75% of variants were classified as uncertain role but nowadays 60.15% of variants are classified of unknown significance. Interpretation: Reclassification occurred in more than 70% of rare variants associated with inherited arrhythmogenic syndromes. Our results support the periodical reclassification and personalized clinical translation of rare variants to improve diagnosis and adjust treatment. Funding: Obra Social "La Caixa Foundation" (ID 100010434, LCF/PR/GN16/50290001 and LCF/PR/GN19/50320002), Fondo Investigacion Sanitaria (FIS PI16/01203 and FIS, PI17/01690), Sociedad Española de Cardiología, and “Fundacio Privada Daniel Bravo Andreu”.

Published
2020

80. Update on the genetic basis of sudden unexpected death in epilepsy

Author

Coll, M., Oliva, Antonio, Grassi, S., Brugada, R., Campuzano, O., Oliva A. (ORCID:0000-0001-7120-616X), Coll, M., Oliva, Antonio, Grassi, S., Brugada, R., Campuzano, O., and Oliva A. (ORCID:0000-0001-7120-616X)

Abstract

Epilepsy is a common neurological disorder associated with increased morbidity and mortality. Sudden unexpected death in epilepsy, also known as SUDEP, is the main cause of death in patients with epilepsy. SUDEP has an incidence of 1.2 per 1000 person-years in adults and 0.2 per 1000 person-years in children. SUDEP accounts for 8–17% of deaths in patients with epilepsy. It is commonly associated with a history of generalized tonic-clonic seizures, and its risk may be increased by other factors such as postictal electroencephalographic suppression, prone sleeping position, altered heart rate variability, conduction abnormalities, gender, or antiepileptic medications. Recently, electrocardiograms, electroencephalograms, and imaging markers have helped clinicians stratify SUDEP risk and identify patients in need of close monitoring. However, the pathophysiology of SUDEP is likely multifactorial and still unknown. Improving the knowledge of SUDEP incidence, risk factors, and biomarkers can help design and implement effective prevention strategies.

Published
2019

82. An enigmatic case of cardiac death in an 18-years old girl.

Author

LANZA, G. A., COLL, M., GRASSI, S., ARENA, V., CAMPUZANO, O., CALÒ, L., RUVO, E. DE, BRUGADA, R., and OLIVA, A.

Abstract

We report a case of unusual and unexplained cardiac death in an 18-years old female patient with congenital neurosensorial deafness. The fatal event was characterized by an initial syncopal episode, associated with a wide QRS tachycardia (around 110 bpm) but stable hemodynamic conditions. The patient, however, subsequently developed severe hypotension and progressive bradyarrhythmias until asystole and lack of cardiac response to resuscitation maneuvers and ventricular pacing. [ABSTRACT FROM AUTHOR]

Published
2021

85. MINIMAL RESIDUAL DISEASE (MRD) EVALUATION IN LYMPHOMAS WITHIN THE FIL (FONDAZIONE ITALIANA LINFOMI) MRD NETWORK: INTER-LABORATORY REPRODUCIBILITY ON BORDERLINE SAMPLES

Author

Della Starza, I, Cavalli, M, De Novi, LA, Genuardi, E, Mantoan, B, Drandi, D, Monitillo, L, Ciabatti, E, Grassi, S, Gazzola, A, Mannu, C, Agostinelli, C, Piccaluga, PP, Galimberti, S, Guarini, A, Foa, R, Ladetto, M, Ferrero, S, Del Giudice, I, Della Starza, I, Cavalli, M, De Novi, LA, Genuardi, E, Mantoan, B, Drandi, D, Monitillo, L, Ciabatti, E, Grassi, S, Gazzola, A, Mannu, C, Agostinelli, C, Piccaluga, PP, Galimberti, S, Guarini, A, Foa, R, Ladetto, M, Ferrero, S, and Del Giudice, I

Subjects
MINIMAL RESIDUAL DISEASE (MRD), LYMPHOMAS
Published
2017

88. PANTOPRAZOLE IN ERADICATION OF PEPTIC ULCER H PYLORI (H PYLORI) POSITIVE PATIENTS: A MULTICENTRE RANDOMISED PROSPECTIVE STUDY BY GISU (INTERDISCIPLINARY ULCER STUDY GROUP)

Author

Di Mario, F., Dal Bo', N., Battaglia, G., Benedetti, E., Bottona, E., Caroli, A., Chilovi, F., Costan, F., De Bastiani, R., De Berardinis, F., De Pretis, G., De Bernardin, M., Fedrizzi, F., Franceshi, M., Germanà, B., Grassi, S. A., Magalini, M., Marcon, V., Marin, R., Meggiato, T., Melina, V., Monica, F., Orzes, N., Piazzi, L., Pilotto, A., Ronzani, G., Salandin, S., Saggioro, A., Tafner, G., Vianello, F., and Vecchiati, U.

Published
1999

94. Forecast Density Combinations of Dynamic Models and Data Driven Portfolio Strategies

Author

Basturk, N., Borowska, A., Grassi, S., Lennart Hoogerheide, Herman (H.K.) van Dijk, Econometrics and Operations Research, Tinbergen Institute, and Econometrics and Data Science

Subjects
momentum strategy, Samfunnsvitenskap: 200::Økonomi: 210::Samfunnsøkonomi: 212 [VDP], Bayes estimates, forecast combination, ddc:330, C15, C10, C11, filtering methods
Abstract

A dynamic asset-allocation model is specified in probabilistic terms as a combination of return distributions resulting from multiple pairs of dynamic models and portfolio strategies based on momentum patterns in US industry returns. The nonlinear state space representation of the model allows efficient and robust simulation-based Bayesian inference using a novel non-linear filter. Combination weights can be cross-correlated and correlated over time using feedback mechanisms. Diagnostic analysis gives insight into model and strategy misspecification. Empirical results show that a smaller flexible model-strategy combination performs better in terms of expected return and risk than a larger basic model-strategy combination. Dynamic patterns in combination weights and diagnostic learning provide useful signals for improved modelling and policy, in particular, from a risk-management perspective.

Published
2018

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