539 results on '"Gram, Inger T."'
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52. Prospective seroepidemiologic study on the role of Human Papillomavirus and other infections in cervical carcinogenesis: Evidence from the EPIC cohort
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Castellsagué, Xavier, Pawlita, Michael, Roura, Esther, Margall, Núria, Waterboer, Tim, Bosch, Xavier F., de Sanjosé, Silvia, Gonzalez, Carlos Alberto, Dillner, Joakim, Gram, Inger T., Tjønneland, Anne, Munk, Christian, Pala, Valeria, Palli, Domenico, Khaw, Kay-Tee, Barnabas, Ruanne V., Overvad, Kim, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Fagherazzi, Guy, Kaaks, Rudolf, Lukanova, Annekatrin, Steffen, Annika, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Klinaki, Eleni, Tumino, Rosario, Sacerdote, Carlotta, Mattiello, Amalia, Bueno-de-Mesquita, H. B(as), Peeters, Petra H., Lund, Eiliv, Weiderpass, Elisabete, Quirós, Ramón J., Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Larrañaga, Nerea, Ekström, Johanna, Hortlund, Maria, Lindquist, David, Wareham, Nick, Travis, Ruth C., Rinaldi, Sabina, Tommasino, Massimo, Franceschi, Silvia, and Riboli, Elio
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- 2014
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53. Active and passive cigarette smoking and breast cancer risk: Results from the EPIC cohort
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Dossus, Laure, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Gram, Inger T., Vilier, Alice, Fervers, Béatrice, Manjer, Jonas, Tjonneland, Anne, Olsen, Anja, Overvad, Kim, Chang-Claude, Jenny, Boeing, Heiner, Steffen, Annika, Trichopoulou, Antonia, Lagiou, Pagona, Sarantopoulou, Maria, Palli, Domenico, Berrino, Franco, Tumino, Rosario, Vineis, Paolo, Mattiello, Amalia, Bueno-de-Mesquita, Bas H., van Duijnhoven, Franzel J.B., Bakker, Marieke F., Peeters, Petra HM, Weiderpass, Elisabete, Bjerkaas, Eivind, Braaten, Tonje, Menéndez, Virginia, Agudo, Antonio, Sanchez, Maria-Jose, Amiano, Pilar, Tormo, Maria-Jose, Barricarte, Aurelio, Butt, Salma, Khaw, Kay-Tee, Wareham, Nicholas, Key, Tim J., Travis, Ruth C., Rinaldi, Sabina, McCormack, Valerie, Romieu, Isabelle, Cox, David G., Norat, Teresa, Riboli, Elio, and Clavel-Chapelon, Françoise
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- 2014
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54. Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study
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Dimou, Niki, primary, Yarmolinsky, James, additional, Bouras, Emmanouil, additional, Tsilidis, Konstantinos K., additional, Martin, Richard M., additional, Lewis, Sarah J., additional, Gram, Inger T., additional, Bakker, Marije F., additional, Brenner, Hermann, additional, Figueiredo, Jane C., additional, Fortner, Renée T., additional, Gruber, Stephen B., additional, van Guelpen, Bethany, additional, Hsu, Li, additional, Kaaks, Rudolf, additional, Kweon, Sun-Seog, additional, Lin, Yi, additional, Lindor, Noralane M., additional, Newcomb, Polly A., additional, Sánchez, Maria-Jose, additional, Severi, Gianluca, additional, Tindle, Hilary A., additional, Tumino, Rosario, additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, and Murphy, Neil, additional
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- 2021
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55. Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study
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Singleton, Rosie K., primary, Heath, Alicia K., additional, Clasen, Joanna L., additional, Scelo, Ghislaine, additional, Johansson, Mattias, additional, Calvez-Kelm, Florence Le, additional, Weiderpass, Elisabete, additional, Liedberg, Fredrik, additional, Ljungberg, Börje, additional, Harbs, Justin, additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Dahm, Christina C., additional, Kaaks, Rudolf, additional, Fortner, Renée T., additional, Panico, Salvatore, additional, Tagliabue, Giovanna, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Gram, Inger T., additional, Santiuste, Carmen, additional, Bonet, Catalina, additional, Rodriguez-Barranco, Miguel, additional, Schulze, Mattias B., additional, Bergmann, Manuela M., additional, Travis, Ruth C., additional, Tzoulaki, Ioanna, additional, Riboli, Elio, additional, and Muller, David C., additional
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- 2021
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56. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk : A Prospective Study in the EPIC Cohort
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Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjonneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, Duell, Eric J., Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjonneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Häggström, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, and Duell, Eric J.
- Abstract
Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. Methods: Weused an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR= 5vs1 = 0.48; 0.25-0.90; Ptrend in parous women = 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR = 1.27; 1.03-1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non-muscleinvasive urothelial carcinoma risk was observed. Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.
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- 2020
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57. Adult weight change and premenopausal breast cancer risk : A prospective pooled analysis of data from 628,463 women
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Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., Swerdlow, Anthony J., Schoemaker, Minouk J., Nichols, Hazel B., Wright, Lauren B., Brook, Mark N., Jones, Michael E., O'Brien, Katie M., Adami, Hans-Olov, Baglietto, Laura, Bernstein, Leslie, Bertrand, Kimberly A., Boutron-Ruault, Marie-Christine, Chen, Yu, Connor, Avonne E., Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Kaaks, Rudolf, Key, Timothy J., Kirsh, Victoria A., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Ma, Huiyan, Milne, Roger L., Ozasa, Kotaro, Palmer, Julie R., Riboli, Elio, Rohan, Thomas E., Sacerdote, Carlotta, Sadakane, Atsuko, Sund, Malin, Tamimi, Rulla M., Trichopoulou, Antonia, Ursin, Giske, Visvanathan, Kala, Weiderpass, Elisabete, Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Sandler, Dale P., and Swerdlow, Anthony J.
- Abstract
Early-adulthood body size is strongly inversely associated with risk of premenopausal breast cancer. It is unclear whether subsequent changes in weight affect risk. We pooled individual-level data from 17 prospective studies to investigate the association of weight change with premenopausal breast cancer risk, considering strata of initial weight, timing of weight change, other breast cancer risk factors and breast cancer subtype. Hazard ratios (HR) and 95% confidence intervals (CI) were obtained using Cox regression. Among 628,463 women, 10,886 were diagnosed with breast cancer before menopause. Models adjusted for initial weight at ages 18-24 years and other breast cancer risk factors showed that weight gain from ages 18-24 to 35-44 or to 45-54 years was inversely associated with breast cancer overall (e.g., HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.95-0.98) and with oestrogen-receptor(ER)-positive breast cancer (HR per 5 kg to ages 45-54: 0.96, 95% CI: 0.94-0.98). Weight gain from ages 25-34 was inversely associated with ER-positive breast cancer only and weight gain from ages 35-44 was not associated with risk. None of these weight gains were associated with ER-negative breast cancer. Weight loss was not consistently associated with overall or ER-specific risk after adjusting for initial weight. Weight increase from early-adulthood to ages 45-54 years is associated with a reduced premenopausal breast cancer risk independently of early-adulthood weight. Biological explanations are needed to account for these two separate factors.
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- 2020
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58. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site : The Ovarian Cancer Cohort Consortium
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Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, V, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Håkansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.
- Abstract
Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites. Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests. Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases. Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site. Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.
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- 2020
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59. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles : An Analysis from the Ovarian Cancer Cohort Consortium (OC3)
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Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Trabert, Britton, Tworoger, Shelley S., O'Brien, Katie M., Townsend, Mary K., Fortner, Renee T., Iversen, Edwin S., Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A., Bernstein, Leslie, Brinton, Louise A., Buring, Julie E., Dossus, Laure, Fraser, Gary E., Gaudet, Mia M., Giles, Graham G., Gram, Inger T., Harris, Holly R., Bolton, Judith Hoffman, Idahl, Annika, Jones, Michael E., Kaaks, Rudolf, Kirsh, Victoria A., Knutsen, Synnove F., Kvaskoff, Marina, Lacey, James, V, Lee, I-Min, Milne, Roger L., Onland-Moret, N. Charlotte, Overvad, Kim, Patel, Alpa, V, Peters, Ulrike, Poynter, Jenny N., Riboli, Elio, Robien, Kim, Rohan, Thomas E., Sandler, Dale P., Schairer, Catherine, Schouten, Leo J., Setiawan, Veronica W., Swerdlow, Anthony J., Travis, Ruth C., Trichopoulou, Antonia, van den Brandt, Piet A., Visvanathan, Kala, Wilkens, Lynne R., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
- Abstract
Repeated exposure to the acute proinflammatory environment that follows ovulation at the ovarian surface and distal fallopian tube over a woman's reproductive years may increase ovarian cancer risk. To address this, analyses included individual-level data from 558,709 naturally menopausal women across 20 prospective cohorts, among whom 3,246 developed invasive epithelial ovarian cancer (2,045 serous, 319 endometrioid, 184 mucinous, 121 clear cell, 577 other/unknown). Cox models were used to estimate multivariable-adjusted HRs between lifetime ovulatory cycles (LOC) and its components and ovarian cancer risk overall and by histotype. Women in the 90th percentile of LOC (>514 cycles) were almost twice as likely to be diagnosed with ovarian cancer than women in the 10th percentile (<294) [HR (95% confidence interval): 1.92 (1.60-2.30)]. Risk increased 14% per 5-year increase in LOC (60 cycles) [(1.10-1.17)]; this association remained after adjustment for LOC components: number of pregnancies and oral contraceptive use [1.08 (1.04-1.12)]. The association varied by histotype, with increased risk of serous [1.13 (1.09-1.17)], endometrioid [1.20 (1.10-1.32)], and clear cell [1.37 (1.18-1.58)], but not mucinous [0.99 (0.88-1.10), P-heterogeneity = 0.01] tumors. Heterogeneity across histotypes was reduced [P-heterogeneity = 0.15] with adjustment for LOC components [1.08 serous, 1.11 endometrioid, 1.26 clear cell, 0.94 mucinous]. Although the 10-year absolute risk of ovarian cancer is small, it roughly doubles as the number of LOC rises from approximately 300 to 500. The consistency and linearity of effects strongly support the hypothesis that each ovulation leads to small increases in the risk of most ovarian cancers, a risk that cumulates through life, suggesting this as an important area for identifying intervention strategies.
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- 2020
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60. Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk : Results from the EPIC cohort
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Idahl, Annika, Le Cornet, Charlotte, Gonzalez Maldonado, Sandra, Waterboer, Tim, Bender, Noemi, Tjonneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fournier, Agnes, Kvaskoff, Marina, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Onland-Moret, N. Charlotte, Gram, Inger T., Weiderpass, Elisabete, Quiros, Jose R., Duell, Eric J., Sanchez, Maria-Jose, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Gil, Leire, Brandstedt, Jenny, Riesbeck, Kristian, Lundin, Eva, Khaw, Kay-Tee, Perez-Cornago, Aurora, Gunter, Marc J., Dossus, Laure, Kaaks, Rudolf, Fortner, Renee T., Idahl, Annika, Le Cornet, Charlotte, Gonzalez Maldonado, Sandra, Waterboer, Tim, Bender, Noemi, Tjonneland, Anne, Hansen, Louise, Boutron-Ruault, Marie-Christine, Fournier, Agnes, Kvaskoff, Marina, Boeing, Heiner, Trichopoulou, Antonia, Valanou, Elisavet, Peppa, Eleni, Palli, Domenico, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, Onland-Moret, N. Charlotte, Gram, Inger T., Weiderpass, Elisabete, Quiros, Jose R., Duell, Eric J., Sanchez, Maria-Jose, Chirlaque, Maria-Dolores, Barricarte, Aurelio, Gil, Leire, Brandstedt, Jenny, Riesbeck, Kristian, Lundin, Eva, Khaw, Kay-Tee, Perez-Cornago, Aurora, Gunter, Marc J., Dossus, Laure, Kaaks, Rudolf, and Fortner, Renee T.
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A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation after sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case‐control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV‐2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead‐based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR = 2.30 [95% CI = 1.22‐4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60‐1) was associated with higher risk of EOC overall (1.36 [1.13‐1.64]) and with the serous subtype (1.44 [1.12‐1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV‐2 was associated with higher risk of endometrioid EOC (2.35 [1.24‐4.43]). The findings of our study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV‐2 might promote the development of endometrioid disease.
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- 2020
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61. Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D‐binding protein isoforms
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Gibbs, David Corley, Bostick, Roberd M., McCullough, Marjorie L., Um, Caroline Y., Flanders, W. Dana, Jenab, Mazda, Weiderpass, Elisabete, Gylling, Björn, Gram, Inger T., Heath, Alicia K., Colorado-Yohar, Sandra, Dahm, Christina C., Bueno-de-Mesquita, Bas, Perez-Cornago, Aurora, Trichopoulou, Antonia, Tumino, Rosario, Kühn, Tilman, Fedirko, Veronika, Gibbs, David Corley, Bostick, Roberd M., McCullough, Marjorie L., Um, Caroline Y., Flanders, W. Dana, Jenab, Mazda, Weiderpass, Elisabete, Gylling, Björn, Gram, Inger T., Heath, Alicia K., Colorado-Yohar, Sandra, Dahm, Christina C., Bueno-de-Mesquita, Bas, Perez-Cornago, Aurora, Trichopoulou, Antonia, Tumino, Rosario, Kühn, Tilman, and Fedirko, Veronika
- Abstract
Lower prediagnostic circulating 25‐hydroxyvitamin D (25[OH]D)—considered the best marker of total vitamin D exposure—is associated with higher mortality risk among colorectal cancer (CRC) patients. However, it is unknown whether this association differs by the vitamin D‐binding protein (GC) isoform Gc2 (encoded by GC rs4588*C>A, Thr436Lys), which may substantially affect vitamin D metabolism and modify associations of 25(OH)D with colorectal neoplasm risk. Prediagnostic 25(OH)D‐mortality associations according to Gc2 isoform were estimated using multivariable Cox proportional hazards regression among 1281 CRC cases (635 deaths, 483 from CRC) from two large prospective cohorts conducted in the United States (Cancer Prevention Study‐II) and Europe (European Prospective Investigation into Cancer and Nutrition). 25(OH)D measurements were calibrated to a single assay, season standardized, and categorized using Institute of Medicine recommendations (deficient [<30], insufficient [30 ‐ <50], sufficient [≥50 nmol/L]). In the pooled analysis, multivariable‐adjusted hazard ratios (HRs) for CRC‐specific mortality associated with deficient relative to sufficient 25(OH)D concentrations were 2.24 (95% CI 1.44‐3.49) among cases with the Gc2 isoform, and 0.94 (95% CI 0.68‐1.22) among cases without Gc2 (P interaction = .0002). The corresponding HRs for all‐cause mortality were 1.80 (95% CI 1.24‐2.60) among those with Gc2, and 1.12 (95% CI 0.84‐1.51) among those without Gc2 (P interaction = .004). Our findings suggest that the association of prediagnostic vitamin D status with mortality among CRC patients may differ by functional GC isoforms, and patients who inherit the Gc2 isoform (GC rs4588*A) may particularly benefit from higher circulating 25(OH)D for improved CRC prognosis.
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- 2020
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62. Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition
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Yammine, Sahar, Huybrechts, Inge, Biessy, Carine, Dossus, Laure, Aglago, Elom K., Naudin, Sabine, Ferrari, Pietro, Weiderpass, Elisabete, Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Mancini, Francesca R., Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Fortner, Renee T., Kaaks, Rudolf, Schulze, Matthias B., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Benetou, Vassiliki, Masala, Giovanna, Krogh, Vittorio, Mattiello, Amalia, Macciotta, Alessandra, Gram, Inger T., Skeie, Guri, Quiros, Jose R., Agudo, Antonio, Sanchez, Maria-Jose, Chirlaque, Maria-Dolores, Ardanaz, Eva, Gil, Leire, Sartor, Hanna, Drake, Isabel, Idahl, Annika, Lundin, Eva, Aune, Dagfinn, Ward, Heather, Merritt, Melissa A., Allen, Naomi E., Gunter, Marc J., Chajes, Veronique, Yammine, Sahar, Huybrechts, Inge, Biessy, Carine, Dossus, Laure, Aglago, Elom K., Naudin, Sabine, Ferrari, Pietro, Weiderpass, Elisabete, Tjonneland, Anne, Hansen, Louise, Overvad, Kim, Mancini, Francesca R., Boutron-Ruault, Marie-Christine, Kvaskoff, Marina, Fortner, Renee T., Kaaks, Rudolf, Schulze, Matthias B., Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Benetou, Vassiliki, Masala, Giovanna, Krogh, Vittorio, Mattiello, Amalia, Macciotta, Alessandra, Gram, Inger T., Skeie, Guri, Quiros, Jose R., Agudo, Antonio, Sanchez, Maria-Jose, Chirlaque, Maria-Dolores, Ardanaz, Eva, Gil, Leire, Sartor, Hanna, Drake, Isabel, Idahl, Annika, Lundin, Eva, Aune, Dagfinn, Ward, Heather, Merritt, Melissa A., Allen, Naomi E., Gunter, Marc J., and Chajes, Veronique
- Abstract
Background: Fatty acids impact obesity, estrogens, and inflammation, which are risk factors for ovarian cancer. Few epidemiologic studies have investigated the association of fatty acids with ovarian cancer. Methods: Within the European Prospective Investigation into Cancer and Nutrition (EPIC), 1,486 incident ovarian cancer cases were identified. Cox proportional hazard models with adjustment for ovarian cancer risk factors were used to estimate HRs of ovarian cancer across quintiles of intake of fatty acids. False discovery rate was computed to control for multiple testing. Multivariable conditional logistic regression models were used to estimate ORs of ovarian cancer across tertiles of plasma fatty acids among 633 cases and two matched controls in a nested case-control analysis. Results: Apositive association was found between ovarian cancer and intake of industrial trans elaidic acid [HR comparing fifth with first quintile(Q5-Q1) = 1.29; 95% confidence interval (CI) = 1.03-1.62; P-trend = 0.02, q-value = 0.06]. Dietary intakes of n-6 linoleic acid (HRQ5-Q1 = 1.10; 95% CI = 1.01-1.21; P-trend = 0.03) and n-3 alpha-linolenic acid (HRQ5-Q1 = 1.18; 95% CI = 1.05-1.34; P-trend = 0.007) from deep-frying fats were also positively associated with ovarian cancer. Suggestive associations were reported for circulating elaidic (OR comparing third with first tertile(T3-T1) = 1.39; 95% CI = 0.99-1.94; P-trend = 0.06) anda-linolenic acids (ORT3-T1 = 1.30; 95% CI = 0.98-1.72; P-trend = 0.06). Conclusions: Our results suggest that higher intakes and circulating levels of industrial trans elaidic acid, and higher intakes of linoleic acid and alpha-linolenic acid from deep-frying fat, may be associated with greater risk of ovarian cancer. Impact: If causal, eliminating industrial trans-fatty acids could offer a straightforward public health action for reducing ovarian cancer risk.
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- 2020
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63. Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort
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Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, Hughes, David J., Butt, Julia, Jenab, Mazda, Pawlita, Michael, Tjonneland, Anne, Kyro, Cecilie, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Dong, Catherine, Kaaks, Rudolf, Kuhn, Tilman, Boeing, Heiner, Schulze, Matthias B., Trichopoulou, Antonia, Karakatsani, Anna, La Vecchia, Carlo, Palli, Domenico, Agnoli, Claudia, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Bueno-de-Mesquita, Bas, Vermeulen, Roel, Gram, Inger T., Weiderpass, Elisabete, Borch, Kristin Benjaminsen, Quiros, Jose Ramon, Agudo, Antonio, Rodriguez-Barranco, Miguel, Santiuste, Carmen, Ardanaz, Eva, van Guelpen, Bethany, Harlid, Sophia, Imaz, Liher, Perez-Cornago, Aurora, Gunter, Marc J., Zouiouich, Semi, Park, Jin Young, Riboli, Elio, Cross, Amanda J., Heath, Alicia K., Waterboer, Tim, and Hughes, David J.
- Abstract
Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99-1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence.
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- 2020
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64. The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3)
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Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Wentzensen, Nicolas, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Trabert, Britton, Tworoger, Shelley S, O'Brien, Katie M, Townsend, Mary K, Fortner, Renée T, Iversen, Edwin S, Hartge, Patricia, White, Emily, Amiano, Pilar, Arslan, Alan A, Bernstein, Leslie, Brinton, Louise A, Buring, Julie E, Dossus, Laure, Fraser, Gary E, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Harris, Holly R, Hoffman Bolton, Judith, Idahl, Annika, Jones, Michael E, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove F, Kvaskoff, Marina, Lacey, James V, Lee, I-Min, Milne, Roger L, Onland-Moret, N Charlotte, Overvad, Kim, Patel, Alpa V, Peters, Ulrike, Poynter, Jenny N, Riboli, Elio, Robien, Kim, Rohan, Thomas E, Sandler, Dale P, Schairer, Catherine, Schouten, Leo J, Setiawan, Veronica Wendy, Swerdlow, Anthony J, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Visvanathan, Kala, Wilkens, Lynne R, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Wentzensen, Nicolas
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- 2020
65. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site:The Ovarian Cancer Cohort Consortium
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Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Hakansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., Schouten, Leo J., Fortner, Renee T., Rice, Megan S., Knutsen, Synnove F., Orlich, Michael J., Visvanathan, Kala, Patel, Alpa, Gaudet, Mia M., Tjønneland, Anne, Kvaskoff, Marina, Kaaks, Rudolf, Trichopolou, Antonia, Pala, Valeria, Onland-Moret, N. Charlotte, Gram, Inger T., Amiano, Pilar, Idahl, Annika, Allen, Naomi E., Weiderpass, Elisabete, Poynter, Jenny N., Robien, Kim, Giles, Graham G., Milne, Roger L., Setiawan, Veronica W., Merritt, Melissa A., van den Brandt, Piet A., Zeleniuch-Jacquotte, Anne, Arslan, Alan A., O'Brien, Katie M., Sandler, Dale P., Wolk, Alicja, Hakansson, Niclas, Harris, Holly R., Trabert, Britton, Wentzensen, Nicolas, Tworoger, Shelley S., and Schouten, Leo J.
- Abstract
Background: Epithelial ovarian, fallopian tube, and primary peritoneal cancers have shared developmental pathways. Few studies have prospectively examined heterogeneity in risk factor associations across these three anatomic sites.Methods: We identified 3,738 ovarian, 337 peritoneal, and 176 fallopian tube incident cancer cases in 891,731 women from 15 prospective cohorts in the Ovarian Cancer Cohort Consortium. Associations between 18 putative risk factors and risk of ovarian, peritoneal, and fallopian tube cancer, overall and for serous and high-grade serous tumors, were evaluated using competing risks Cox proportional hazards regression. Heterogeneity was assessed by likelihood ratio tests.Results: Most associations did not vary by tumor site (P-het = 0.05). Associations between first pregnancy (P-het = 0.04), tubal ligation (P-het = 0.01), and early-adult (age 18-21 years) body mass index (BMI; P-het = 0.02) and risk differed between ovarian and peritoneal cancers. The association between early-adult BMI and risk further differed between peritoneal and fallopian tube cancer (P-het = 0.03). First pregnancy and tubal ligation were inversely associated with ovarian, but not peritoneal, cancer. Higher early-adult BMI was associated with higher risk of peritoneal, but not ovarian or fallopian tube, cancer. Patterns were generally similar when restricted to serous and high-grade serous cases.Conclusions: Ovarian, fallopian tube, and primary peritoneal cancers appear to have both shared and distinct etiologic pathways, although most risk factors appear to have similar associations by anatomic site.Impact: Further studies on the mechanisms underlying the differences in risk profiles may provide insights regarding the developmental origins of tumors arising in the peritoneal cavity and inform prevention efforts.
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- 2020
66. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk:A Prospective Study in the EPIC Cohort
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Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjønneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Haeggstroem, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, Duell, Eric J., Lujan-Barroso, Leila, Botteri, Edoardo, Caini, Saverio, Ljungberg, Boerje, Roswall, Nina, Tjønneland, Anne, Bueno-de-Mesquita, Bas, Gram, Inger T., Tumino, Rosario, Kiemeney, Lambertus A., Liedberg, Fredrik, Stocks, Tanja, Gunter, Marc J., Murphy, Neil, Cervenka, Iris, Fournier, Agnes, Kvaskoff, Marina, Haeggstroem, Christel, Overvad, Kim, Lund, Eiliv, Waaseth, Marit, Turzanski Fortner, Renee, Kuhn, Tilman, Menendez, Virginia, Sanchez, Maria-Jose, Santiuste, Carmen, Perez-Cornago, Aurora, Zamora-Ros, Raul, Cross, Amanda J., Trichopoulou, Antonia, Karakatsani, Anna, Peppa, Eleni, Palli, Domenico, Krogh, Vittorio, Sciannameo, Veronica, Mattiello, Amalia, Panico, Salvatore, van Gils, Carla H., Onland-Moret, N. Charlotte, Barricarte, Aurelio, Amiano, Pilar, Khaw, Kay-Tee, Boeing, Heiner, Weiderpass, Elisabete, and Duell, Eric J.
- Abstract
Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk.Methods: Weused an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non-muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models.Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR= 5vs1 = 0.48; 0.25-0.90; Ptrend in parous women = 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR = 1.27; 1.03-1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non-muscleinvasive urothelial carcinoma risk was observed.Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk.Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells.
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- 2020
67. Red Blood Cell Fatty Acids and Risk of Colorectal Cancer in The European Prospective Investigation into Cancer and Nutrition (EPIC)
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Linseisen, Jakob, primary, Grundmann, Nina, additional, Zoller, Dorothee, additional, Kühn, Tilman, additional, Jansen, Eugène H.J.M., additional, Chajès, Veronique, additional, Fedirko, Veronika, additional, Weiderpass, Elisabete, additional, Dahm, Christina C., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Aleksandrova, Krasimira, additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Masala, Giovanna, additional, De Marco, Laura, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel, additional, Gram, Inger T., additional, Skeie, Guri, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Agudo, Antonio, additional, Sánchez, Maria-José, additional, Amiano, Pilar, additional, Wennberg, Maria, additional, Bodén, Stina, additional, Perez-Cornago, Aurora, additional, Aglago, Elom K., additional, Gunter, Marc J., additional, Jenab, Mazda, additional, Heath, Alicia K., additional, and Nieters, Alexandra, additional
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- 2021
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68. Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort
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Aglago, Elom K., primary, Rinaldi, Sabina, additional, Freisling, Heinz, additional, Jiao, Li, additional, Hughes, David J., additional, Fedirko, Veronika, additional, Schalkwijk, Casper G., additional, Weiderpass, Elisabete, additional, Dahm, Christina C., additional, Overvad, Kim, additional, Eriksen, Anne Kirstine, additional, Kyrø, Cecilie, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Katzke, Verena, additional, Kühn, Tilman, additional, Schulze, Matthias B., additional, Aleksandrova, Krasimira, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Bueno-de-Mesquita, Bas, additional, van Gils, Carla H., additional, Sandanger, Torkjel M., additional, Gram, Inger T., additional, Skeie, Guri, additional, Quirós, J. Ramón, additional, Jakszyn, Paula, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Johansson, Ingegerd, additional, Harlid, Sophia, additional, Perez-Cornago, Aurora, additional, Mayén, Ana-Lucia, additional, Cordova, Reynalda, additional, Gunter, Marc J., additional, Vineis, Paolo, additional, Cross, Amanda J., additional, Riboli, Elio, additional, and Jenab, Mazda, additional
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- 2021
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69. Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study
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Gram, Inger T., Lukanova, Annekatrin, Brill, Ilene, Braaten, Tonje, Lund, Eiliv, Lundin, Eva, Overvad, Kim, Tjnneland, Anne, Clavel-Chapelon, Francoise, Chabbert-Buffet, Nathalie, Bamia, Christina, Trichopoulou, Antonia, Zylis, Dimosthenis, Masala, Giovanna, Berrino, Franco, Galasso, Rocco, Tumino, Rosario, Sacerdote, Carlotta, Gavrilyuk, Oxana, Kristiansen, Steinar, Rodríguez, Laudina, Bonet, Catalina, Huerta, José María, Barricarte, Aurelio, Sánchez, Maria-José, Dorronsoro, Miren, Jirström, Karin, Almquist, Martin, Idahl, Annika, Bueno-de-Mesquita, Bas H., Braem, Marie, Onland-Moret, Charlotte, Tsilidis, Konstantinos K., Allen, Naomi E., Fedirko, Veronika, Riboli, E., and Kaaks, Rudolf
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- 2012
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70. N-Acetyltransferase 2 Polymorphisms, Tobacco Smoking, and Breast Cancer Risk in the Breast and Prostate Cancer Cohort Consortium
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Cox, David G., Dostal, Lucie, Hunter, David J., Le Marchand, Loïc, Hoover, Robert, Ziegler, Regina G., Thun, Michael J., Diver, W. Ryan, Stevens, Victoria L., Amiano, Pilar, Boutron-Rualt, Marie-Christine, Campa, Daniele, van Duijnhoven, Fränzel J. B., Gram, Inger T., Kaaks, Rudolf, Khaw, Kay-Tee, Riboli, Elio, Sund, Malin, Trichopoulos, Demitrios, Tumino, Rosario, Vogel, Ulla, Kraft, Peter, Buring, Julie E., Hankinson, Susan E., Lee, I-Min, Zhang, Shumin M., Lindstrom, Sara, Berg, Christine D., Chanock, Stephen, Isaacs, Claudine, McCarty, Catherine, Haiman, Christopher A., and Henderson, Brian E.
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- 2011
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71. Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
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Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Tjønneland, Anne, Roswall, Nina, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Naska, Ada, Benetou, Vicky, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, van Duijnhoven, Fränzel J.B., Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Sánchez, Maria-José, Jakszyn, Paula, Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy, Hallmans, Göran, Ljungberg, Börje, Key, Tim J., Allen, Naomi E., Khaw, Kay-Tee, Wareham, Nicholas, Slimani, Nadia, Jenab, Mazda, Boffetta, Paolo, Kiemeney, Lambertus A.L.M, and Riboli, Elio
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- 2011
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72. Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Ros, Martine M., Bas Bueno-de-Mesquita, H. B., Büchner, Frederike L., Aben, Katja K.H., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Kaaks, Rudolf, Chang-Claude, Jenny, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Orfanos, Philippos, Stasinopulou, Georgia, Saieva, Calogero, Krogh, Vittorio, Vineis, Paolo, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H.M., van Duijnhoven, Fränzel J.B., Lund, Eiliv, Gram, Inger T, Chirlaque, Maria D, Barricarte, Aurelio, Rodríguez, Laudina, Molina, Esther, Gonzalez, Carlos, Dorronsoro, Miren, Manjer, Jonas, Ehrnström, Roy, Ljungberg, Börje, Allen, Naomi E., Roddam, Andrew W., Khaw, Kay-Tee, Wareham, Nick, Boffetta, Paolo, Slimani, Nadia, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio
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- 2011
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73. Ovarian Cancer Risk Factor Associations by Primary Anatomic Site: The Ovarian Cancer Cohort Consortium
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Fortner, Renée T., primary, Rice, Megan S., additional, Knutsen, Synnove F., additional, Orlich, Michael J., additional, Visvanathan, Kala, additional, Patel, Alpa V., additional, Gaudet, Mia M., additional, Tjønneland, Anne, additional, Kvaskoff, Marina, additional, Kaaks, Rudolf, additional, Trichopolou, Antonia, additional, Pala, Valeria, additional, Onland-Moret, N. Charlotte, additional, Gram, Inger T., additional, Amiano, Pilar, additional, Idahl, Annika, additional, Allen, Naomi E., additional, Weiderpass, Elisabete, additional, Poynter, Jenny N., additional, Robien, Kim, additional, Giles, Graham G., additional, Milne, Roger L., additional, Setiawan, Veronica W., additional, Merritt, Melissa A., additional, van den Brandt, Piet A., additional, Zeleniuch-Jacquotte, Anne, additional, Arslan, Alan A., additional, O'Brien, Katie M., additional, Sandler, Dale P., additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Harris, Holly R., additional, Trabert, Britton, additional, Wentzensen, Nicolas, additional, Tworoger, Shelley S., additional, and Schouten, Leo J., additional
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- 2020
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74. Dietary and Circulating Fatty Acids and Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition
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Yammine, Sahar, primary, Huybrechts, Inge, additional, Biessy, Carine, additional, Dossus, Laure, additional, Aglago, Elom K., additional, Naudin, Sabine, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Overvad, Kim, additional, Mancini, Francesca R., additional, Boutron-Ruault, Marie-Christine, additional, Kvaskoff, Marina, additional, Fortner, Renée T., additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Benetou, Vassiliki, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Mattiello, Amalia, additional, Macciotta, Alessandra, additional, Gram, Inger T., additional, Skeie, Guri, additional, Quirós, Jose R., additional, Agudo, Antonio, additional, Sánchez, Maria-José, additional, Chirlaque, Maria-Dolores, additional, Ardanaz, Eva, additional, Gil, Leire, additional, Sartor, Hanna, additional, Drake, Isabel, additional, Idahl, Annika, additional, Lundin, Eva, additional, Aune, Dagfinn, additional, Ward, Heather, additional, Merritt, Melissa A., additional, Allen, Naomi E., additional, Gunter, Marc J., additional, and Chajès, Véronique, additional
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- 2020
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75. Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort
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Lujan-Barroso, Leila, primary, Botteri, Edoardo, additional, Caini, Saverio, additional, Ljungberg, Börje, additional, Roswall, Nina, additional, Tjønneland, Anne, additional, Bueno-de-Mesquita, Bas, additional, Gram, Inger T., additional, Tumino, Rosario, additional, Kiemeney, Lambertus A., additional, Liedberg, Fredrik, additional, Stocks, Tanja, additional, Gunter, Marc J., additional, Murphy, Neil, additional, Cervenka, Iris, additional, Fournier, Agnès, additional, Kvaskoff, Marina, additional, Häggström, Christel, additional, Overvad, Kim, additional, Lund, Eiliv, additional, Waaseth, Marit, additional, Fortner, Renée Turzanski, additional, Kühn, Tilman, additional, Menéndez, Virginia, additional, Sánchez, Maria-Jose, additional, Santiuste, Carmen, additional, Perez-Cornago, Aurora, additional, Zamora-Ros, Raul, additional, Cross, Amanda J., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Sciannameo, Veronica, additional, Mattiello, Amalia, additional, Panico, Salvatore, additional, van Gils, Carla H., additional, Onland-Moret, N. Charlotte, additional, Barricarte, Aurelio, additional, Amiano, Pilar, additional, Khaw, Kay-Tee, additional, Boeing, Heiner, additional, Weiderpass, Elisabete, additional, and Duell, Eric J., additional
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- 2020
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76. Antibody Responses to Helicobacter pylori and Risk of Developing Colorectal Cancer in a European Cohort
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Butt, Julia, primary, Jenab, Mazda, additional, Pawlita, Michael, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Boutron-Ruault, Marie-Christine, additional, Carbonnel, Franck, additional, Dong, Catherine, additional, Kaaks, Rudolf, additional, Kühn, Tilman, additional, Boeing, Heiner, additional, Schulze, Matthias B., additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, La Vecchia, Carlo, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, Borch, Kristin Benjaminsen, additional, Quirós, Jose Ramón, additional, Agudo, Antonio, additional, Rodríguez-Barranco, Miguel, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Van Guelpen, Bethany, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Perez-Cornago, Aurora, additional, Gunter, Marc J., additional, Zouiouich, Semi, additional, Park, Jin Young, additional, Riboli, Elio, additional, Cross, Amanda J., additional, Heath, Alicia K., additional, Waterboer, Tim, additional, and Hughes, David J., additional
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- 2020
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77. Association of prediagnostic vitamin D status with mortality among colorectal cancer patients differs by common, inherited vitamin D‐binding protein isoforms
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Gibbs, David Corley, primary, Bostick, Roberd M., additional, McCullough, Marjorie L., additional, Um, Caroline Y., additional, Flanders, W. Dana, additional, Jenab, Mazda, additional, Weiderpass, Elisabete, additional, Gylling, Björn, additional, Gram, Inger T., additional, Heath, Alicia K., additional, Colorado‐Yohar, Sandra, additional, Dahm, Christina C., additional, Bueno‐de‐Mesquita, Bas, additional, Perez‐Cornago, Aurora, additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, Kühn, Tilman, additional, and Fedirko, Veronika, additional
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- 2020
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78. Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort
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Idahl, Annika, primary, Le Cornet, Charlotte, additional, González Maldonado, Sandra, additional, Waterboer, Tim, additional, Bender, Noemi, additional, Tjønneland, Anne, additional, Hansen, Louise, additional, Boutron‐Ruault, Marie‐Christine, additional, Fournier, Agnès, additional, Kvaskoff, Marina, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Valanou, Elisavet, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Mattiello, Amalia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Onland‐Moret, N. Charlotte, additional, Gram, Inger T., additional, Weiderpass, Elisabete, additional, Quirós, Jose R., additional, Duell, Eric J., additional, Sánchez, Maria‐Jose, additional, Chirlaque, Maria‐Dolores, additional, Barricarte, Aurelio, additional, Gil, Leire, additional, Brändstedt, Jenny, additional, Riesbeck, Kristian, additional, Lundin, Eva, additional, Khaw, Kay‐Tee, additional, Perez‐Cornago, Aurora, additional, Gunter, Marc J., additional, Dossus, Laure, additional, Kaaks, Rudolf, additional, and Fortner, Renée T., additional
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- 2020
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79. The Risk of Ovarian Cancer Increases with an Increase in the Lifetime Number of Ovulatory Cycles: An Analysis from the Ovarian Cancer Cohort Consortium (OC3)
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Trabert, Britton, primary, Tworoger, Shelley S., additional, O'Brien, Katie M., additional, Townsend, Mary K., additional, Fortner, Renée T., additional, Iversen, Edwin S., additional, Hartge, Patricia, additional, White, Emily, additional, Amiano, Pilar, additional, Arslan, Alan A., additional, Bernstein, Leslie, additional, Brinton, Louise A., additional, Buring, Julie E., additional, Dossus, Laure, additional, Fraser, Gary E., additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Gram, Inger T., additional, Harris, Holly R., additional, Bolton, Judith Hoffman, additional, Idahl, Annika, additional, Jones, Michael E., additional, Kaaks, Rudolf, additional, Kirsh, Victoria A., additional, Knutsen, Synnove F., additional, Kvaskoff, Marina, additional, Lacey, James V., additional, Lee, I-Min, additional, Milne, Roger L., additional, Onland-Moret, N. Charlotte, additional, Overvad, Kim, additional, Patel, Alpa V., additional, Peters, Ulrike, additional, Poynter, Jenny N., additional, Riboli, Elio, additional, Robien, Kim, additional, Rohan, Thomas E., additional, Sandler, Dale P., additional, Schairer, Catherine, additional, Schouten, Leo J., additional, Setiawan, Veronica W., additional, Swerdlow, Anthony J., additional, Travis, Ruth C., additional, Trichopoulou, Antonia, additional, van den Brandt, Piet A., additional, Visvanathan, Kala, additional, Wilkens, Lynne R., additional, Wolk, Alicja, additional, Zeleniuch-Jacquotte, Anne, additional, and Wentzensen, Nicolas, additional
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- 2020
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80. Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women
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Schoemaker, Minouk J., primary, Nichols, Hazel B., additional, Wright, Lauren B., additional, Brook, Mark N., additional, Jones, Michael E., additional, O'Brien, Katie M., additional, Adami, Hans‐Olov, additional, Baglietto, Laura, additional, Bernstein, Leslie, additional, Bertrand, Kimberly A., additional, Boutron‐Ruault, Marie‐Christine, additional, Chen, Yu, additional, Connor, Avonne E., additional, Dossus, Laure, additional, Eliassen, A. Heather, additional, Giles, Graham G., additional, Gram, Inger T., additional, Hankinson, Susan E., additional, Kaaks, Rudolf, additional, Key, Timothy J., additional, Kirsh, Victoria A., additional, Kitahara, Cari M., additional, Larsson, Susanna C., additional, Linet, Martha, additional, Ma, Huiyan, additional, Milne, Roger L., additional, Ozasa, Kotaro, additional, Palmer, Julie R., additional, Riboli, Elio, additional, Rohan, Thomas E., additional, Sacerdote, Carlotta, additional, Sadakane, Atsuko, additional, Sund, Malin, additional, Tamimi, Rulla M., additional, Trichopoulou, Antonia, additional, Ursin, Giske, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, Willett, Walter C., additional, Wolk, Alicja, additional, Zeleniuch‐Jacquotte, Anne, additional, Sandler, Dale P., additional, and Swerdlow, Anthony J., additional
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- 2020
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81. Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex
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Gram, Inger T, primary, Park, Song-Yi, additional, Wilkens, Lynne R, additional, Haiman, Christopher A, additional, and Le Marchand, Loïc, additional
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- 2020
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82. Cigarette smoking, environmental tobacco smoke exposure and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition
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Vrieling, Alina, Bueno-de-Mesquita, Bas H., Boshuizen, Hendriek C., Michaud, Dominique S., Severinsen, Marianne T., Overvad, Kim, Olsen, Anja, Tjnneland, Anne, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Rohrmann, Sabine, Boeing, Heiner, Nöthlings, Ute, Trichopoulou, Antonia, Moutsiou, Eftihia, Dilis, Vardis, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Vineis, Paolo, van Gils, Carla H., Peeters, Petra H.M., Lund, Eiliv, Gram, Inger T., Rodríguez, Laudina, Agudo, Antonio, Larrañaga, Nerea, Sánchez, María-José, Navarro, Carmen, Barricarte, Aurelio, Manjer, Jonas, Lindkvist, Björn, Sund, Malin, Ye, Weimin, Bingham, Sheila, Khaw, Kay-Tee, Roddam, Andrew, Key, Tim, Boffetta, Paolo, Duell, Eric J., Jenab, Mazda, Gallo, Valentina, and Riboli, Elio
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- 2010
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83. Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
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Büchner, Frederike L., Bueno-de-Mesquita, Bas H., Ros, Martine M., Kampman, Ellen, Egevad, Lars, Overvad, Kim, Raaschou-Nielsen, Ole, Tjnneland, Anne, Roswall, Nina, Clavel-Chapelon, Francoise, Boutron-Ruault, Marie-Christine, Touillaud, Marina, Chang-Claude, Jenny, Kaaks, Rudolf, Boeing, Heiner, Weikert, Steffen, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Vineis, Paolo, Tumino, Rosario, Panico, Salvatore, Vrieling, Alina, Peeters, Petra H.M., van Gils, Carla H., Lund, Eiliv, Gram, Inger T., Engeset, Dagrun, Martinez, Carmen, Gonzalez, Carlos A., Larrañaga, Nerea, Ardanaz, Eva, Navarro, Carmen, Rodríguez, Laudina, Manjer, Jonas, Ehrnström, Roy A., Hallmans, Goran, Ljungberg, Borje, Allen, Naomi E., Roddam, Andrew W., Bingham, Sheila, Khaw, Kay-Tee, Slimani, Nadia, Boffetta, Paolo, Jenab, Mazda, Mouw, Traci, Michaud, Dominique S., Kiemeney, Lambertus A.L.M., and Riboli, Elio
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- 2009
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84. The Role of Smoking and Diet in Explaining Educational Inequalities in Lung Cancer Incidence
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Menvielle, Gwenn, Boshuizen, Hendriek, Kunst, Anton E., Dalton, Susanne O., Vineis, Paolo, Bergmann, Manuela M., Hermann, Silke, Ferrari, Pietro, Raaschou-Nielsen, Ole, Tjønneland, Anne, Kaaks, Rudolf, Linseisen, Jakob, Kosti, Maria, Trichopoulou, Antonia, Dilis, Vardis, Palli, Domenico, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Büchner, Frederike L., van Gils, Carla H., Peeters, Petra H. M., Braaten, Tonje, Gram, Inger T., Lund, Eiliv, Rodriguez, Laudina, Agudo, Antonio, Sánchez, Maria-José, Tormo, Maria-José, Ardanaz, Eva, Manjer, Jonas, Wirfält, Elisabet, Hallmans, Göran, Rasmuson, Torgny, Bingham, Sheila, Khaw, Kay-Tee, Allen, Naomi, Key, Tim, Boffetta, Paolo, Duell, Eric J., Slimani, Nadia, Gallo, Valentina, Riboli, Elio, and Bueno-de-Mesquita, H. Bas
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- 2009
85. Cigarette smoking and risk of borderline and invasive epithelial ovarian cancer
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Gram, Inger T., Braaten, Tonje, Adami, Hans-Olov, Lund, Eiliv, and Weiderpass, Elisabete
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- 2008
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86. Ovarian cancer risk factors by tumor aggressiveness: An analysis from the Ovarian Cancer Cohort Consortium
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Fortner, Renee T. Poole, Elizabeth M. Wentzensen, Nicolas A. and Trabert, Britton White, Emily Arslan, Alan A. Patel, V, Alpa and Setiawan, V. Wendy Visvanathan, Kala Weiderpass, Elisabete and Adami, Hans-Olov Black, Amanda Bernstein, Leslie and Brinton, Louise A. Buring, Julie Clendenen, V, Tess and Fournier, Agnes Fraser, Gary Gapstur, Susan M. Gaudet, Mia M. Giles, Graham G. Gram, Inger T. Hartge, Patricia and Hoffman-Bolton, Judith Idahl, Annika Kaaks, Rudolf Kirsh, Victoria A. Knutsen, Synnove Koh, Woon-Puay Lacey, Jr., James V. Lee, I-Min Lundin, Eva Merritt, Melissa A. and Milne, Roger L. Onland-Moret, N. Charlotte Peters, Ulrike and Poynter, Jenny N. Rinaldi, Sabina Robien, Kim Rohan, Thomas and Sanchez, Maria-Jose Schairer, Catherine Schouten, Leo J. and Tjonneland, Anne Townsend, Mary K. Travis, Ruth C. and Trichopoulou, Antonia van den Brandt, Piet A. Vineis, Paolo and Wilkens, Lynne Wolk, Alicja Yang, Hannah P. and Zeleniuch-Jacquotte, Anne Tworoger, Shelley S.
- Abstract
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in = 35 vs. 20 to < 25 kg/m(2), 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
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- 2019
87. Endogenous sex hormones, prolactin and mammographic density in postmenopausal Norwegian women
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Bremnes, Yngve, Ursin, Giske, Bjurstam, Nils, Rinaldi, Sabina, Kaaks, Rudolf, and Gram, Inger T.
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- 2007
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88. Fruit and vegetable consumption and lung cancer risk: Updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Linseisen, Jakob, Rohrmann, Sabine, Miller, Anthony B., Bueno-de-Mesquita, Bas H., Büchner, Frederike L., Vineis, Paolo, Agudo, Antonio, Gram, Inger T., Janson, Lars, Krogh, Vittorio, Overvad, Kim, Rasmuson, Torgny, Schulz, Mandy, Pischon, Tobias, Kaaks, Rudolf, Nieters, Alexandra, Allen, Naomi E., Key, Timothy J., Bingham, Sheila, Khaw, Kay-Tee, Amiano, Pilar, Barricarte, Aurelio, Martinez, Carmen, Navarro, Carmen, Quirós, Ramón, Clavel-Chapelon, Françoise, Boutron-Ruault, Marie-Christine, Touvier, Mathilde, Peeters, Petra H.M., Berglund, Göran, Hallmans, Göran, Lund, Eiliv, Palli, Domenico, Panico, Salvatore, Tumino, Rosario, Tjnneland, Anne, Olsen, Anja, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Autier, Philippe, Boffetta, Paolo, Slimani, Nadia, and Riboli, Elio
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- 2007
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89. Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer: A HuGE–GSEC Review
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Paracchini, Valentina, Raimondi, Sara, Gram, Inger T., Kang, Daehee, Kocabas, Neslihan A., Kristensen, Vessela N., Li, Donghui, Parl, Fritz F., Rylander-Rudqvist, Tove, Soucek, Pavel, Zheng, Wei, Wedren, Sara, and Taioli, Emanuela
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- 2007
90. Breast Cancer Risk After Recent Childbirth : A Pooled Analysis of 15 Prospective Studies
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Nichols, Hazel B, Schoemaker, Minouk J, Cai, Jianwen, Xu, Jiawei, Wright, Lauren B, Brook, Mark N, Jones, Michael E, Adami, Hans-Olov, Baglietto, Laura, Bertrand, Kimberly A, Blot, William J, Boutron-Ruault, Marie-Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Gram, Inger T, Hankinson, Susan E, Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J, Kitahara, Cari M, Larsson, Susanna C., Linet, Martha, Merritt, Melissa A, Milne, Roger L, Pala, Valeria, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Sund, Malin, Tamimi, Rulla M, Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R, Swerdlow, Anthony J, Sandler, Dale P, Nichols, Hazel B, Schoemaker, Minouk J, Cai, Jianwen, Xu, Jiawei, Wright, Lauren B, Brook, Mark N, Jones, Michael E, Adami, Hans-Olov, Baglietto, Laura, Bertrand, Kimberly A, Blot, William J, Boutron-Ruault, Marie-Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A Heather, Giles, Graham G, Gram, Inger T, Hankinson, Susan E, Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J, Kitahara, Cari M, Larsson, Susanna C., Linet, Martha, Merritt, Melissa A, Milne, Roger L, Pala, Valeria, Palmer, Julie R, Peeters, Petra H, Riboli, Elio, Sund, Malin, Tamimi, Rulla M, Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R, Swerdlow, Anthony J, and Sandler, Dale P
- Abstract
Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or specific tumor subtype has rarely been evaluated. Objective: To characterize breast cancer risk in relation to recent childbirth. Design: Pooled analysis of individual-level data from 15 prospective cohort studies. Setting: The international Premenopausal Breast Cancer Collaborative Group. Participants: Women younger than 55 years. Measurements: During 9.6 million person-years of follow-up, 18 826 incident cases of breast cancer were diagnosed. Hazard ratios (HRs) and 95% CIs for breast cancer were calculated using Cox proportional hazards regression. Results: Compared with nulliparous women, parous women had an HR for breast cancer that peaked about 5 years after birth (HR, 1.80 [95% CI, 1.63 to 1.99]) before decreasing to 0.77 (CI, 0.67 to 0.88) after 34 years. The association crossed over from positive to negative about 24 years after birth. The overall pattern was driven by estrogen receptor (ER)-positive breast cancer; no crossover was seen for ER-negative cancer. Increases in breast cancer risk after childbirth were pronounced when combined with a family history of breast cancer and were greater for women who were older at first birth or who had more births. Breastfeeding did not modify overall risk patterns. Limitations: Breast cancer diagnoses during pregnancy were not uniformly distinguishable from early postpartum diagnoses. Data on human epidermal growth factor receptor 2 (HER2) oncogene overexpression were limited. Conclusion: Compared with nulliparous women, parous women have an increased risk for breast cancer for more than 20 years after childbirth. Health care providers should consider recent childbirth a risk factor for breast cancer in young women. Primary Funding Source: The Avon Foundation, the National Institute of Environmental
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- 2019
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91. Ovarian cancer risk factors by tumor aggressiveness : An analysis from the Ovarian Cancer Cohort Consortium.
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Fortner, Renée T, Poole, Elizabeth M, Wentzensen, Nicolas A, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Clendenen, Tess V, Fournier, Agnès, Fraser, Gary, Gapstur, Susan M, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Milne, Roger L, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J, Tjonneland, Anne, Townsend, Mary K, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Fortner, Renée T, Poole, Elizabeth M, Wentzensen, Nicolas A, Trabert, Britton, White, Emily, Arslan, Alan A, Patel, Alpa V, Setiawan, V Wendy, Visvanathan, Kala, Weiderpass, Elisabete, Adami, Hans-Olov, Black, Amanda, Bernstein, Leslie, Brinton, Louise A, Buring, Julie, Clendenen, Tess V, Fournier, Agnès, Fraser, Gary, Gapstur, Susan M, Gaudet, Mia M, Giles, Graham G, Gram, Inger T, Hartge, Patricia, Hoffman-Bolton, Judith, Idahl, Annika, Kaaks, Rudolf, Kirsh, Victoria A, Knutsen, Synnove, Koh, Woon-Puay, Lacey, James V, Lee, I-Min, Lundin, Eva, Merritt, Melissa A, Milne, Roger L, Onland-Moret, N Charlotte, Peters, Ulrike, Poynter, Jenny N, Rinaldi, Sabina, Robien, Kim, Rohan, Thomas, Sánchez, Maria-José, Schairer, Catherine, Schouten, Leo J, Tjonneland, Anne, Townsend, Mary K, Travis, Ruth C, Trichopoulou, Antonia, van den Brandt, Piet A, Vineis, Paolo, Wilkens, Lynne, Wolk, Alicja, Yang, Hannah P, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
- Abstract
Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death in <1 year, n = 864), very aggressive (death in 1 to < 3 years, n = 1,390), moderately aggressive (death in 3 to < 5 years, n = 639), and less aggressive (lived 5+ years, n = 1,691). Using competing risks Cox proportional hazards regression, we assessed heterogeneity of associations by tumor aggressiveness for all cases and among serous and endometrioid/clear cell tumors. Associations between parity (phet = 0.01), family history of ovarian cancer (phet = 0.02), body mass index (BMI; phet ≤ 0.04) and smoking (phet < 0.01) and ovarian cancer risk differed by aggressiveness. A first/single pregnancy, relative to nulliparity, was inversely associated with highly aggressive disease (HR: 0.72; 95% CI [0.58-0.88]), no association was observed for subsequent pregnancies (per pregnancy, 0.97 [0.92-1.02]). In contrast, first and subsequent pregnancies were similarly associated with less aggressive disease (0.87 for both). Family history of ovarian cancer was only associated with risk of less aggressive disease (1.94 [1.47-2.55]). High BMI (≥35 vs. 20 to < 25 kg/m2 , 1.93 [1.46-2.56] and current smoking (vs. never, 1.30 [1.07-1.57]) were associated with increased risk of highly aggressive disease. Results were similar within histotypes. Ovarian cancer risk factors may be directly associated with subtypes defined by tumor aggressiveness, rather than through differential effects on histology. Studies to assess biological pathways are warranted.
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- 2019
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92. High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer : Results from the Ovarian Cancer Cohort Consortium
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Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S., Peres, Lauren C., Mallen, Adrianne R., Townsend, Mary K., Poole, Elizabeth M., Trabert, Britton, Allen, Naomi E., Arslan, Alan A., Dossus, Laure, Fortner, Renee T., Gram, Inger T., Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magliocco, Anthony M., Merritt, Melissa A., Quiros, J. Ramon, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla H., Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S.
- Abstract
Growing epidemiologic evidence supports chronic inflammation as a mechanism of ovarian carcinogenesis. An association between a circulating marker of inflammation, C-reactive protein (CRP), and ovarian cancer risk has been consistently observed, yet, potential heterogeneity of this association by tumor and patient characteristics has not been adequately explored. In this study, we pooled data from case-control studies nested within six cohorts in the Ovarian Cancer Cohort Consortium (OC3) to examine the association between CRP and epithelial ovarian cancer risk overall, by histologic subtype and by participant characteristics. CRP concentrations were measured from prediagnosis serum or plasma in 1,091 cases and 1,951 controls. Multivariable conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI). When CRP was evaluated using tertiles, no associations with ovarian cancer risk were observed. A 67% increased ovarian cancer risk was found for women with CRP concentrations >10 mg/L compared with <1 mg/L (OR = 1.67; 95% CI = 1.12-2.48). A CRP concentration >10 mg/L was positively associated with risk of mucinous (OR = 9.67; 95% CI = 1.10-84.80) and endometrioid carcinoma (OR = 3.41; 95% CI = 1.07-10.92), and suggestively positive, although not statistically significant, for serous (OR = 1.43; 95% CI = 0.82-2.49) and clear cell carcinoma (OR = 2.05; 95% CI = 0.36-11.57; P-heterogeneity = 0.20). Heterogeneity was observed with oral contraceptive use (P-interaction = 0.03), where the increased risk was present only among ever users (OR = 3.24; 95% CI = 1.62-6.47). This study adds to the existing evidence that CRP plays a role in ovarian carcinogenesis and suggests that inflammation may be particularly implicated in the etiology of endometrioid and mucinous carcinoma. Significance: C-reactive protein is involved in ovarian carcinogenesis, and chronic inflammation may be particularly implicated in the etiology of mucinous and endomet
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- 2019
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93. High levels of C-reactive protein are associated with an increased risk of ovarian cancer : Results from the Ovarian Cancer Cohort Consortium
- Author
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Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
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- 2019
94. Reproductive and lifestyle factors and circulating sRANKL and OPG concentrations in women : Results from the EPIC cohort
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Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, Fortner, Renée T, Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, and Fortner, Renée T
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- 2019
95. Development and validation of circulating CA125 prediction models in postmenopausal women
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Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A, Fortner, Renée T, Vitonis, Allison F, Yamamoto, Hidemi, Fichorova, Raina N, Titus, Linda J, Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N Charlotte, Weiderpass, Elisabete, Gram, Inger T, Quirós, J Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J, Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W, Tworoger, Shelley S, Terry, Kathryn L, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Sasamoto, Naoko, Babic, Ana, Rosner, Bernard A, Fortner, Renée T, Vitonis, Allison F, Yamamoto, Hidemi, Fichorova, Raina N, Titus, Linda J, Tjønneland, Anne, Hansen, Louise, Kvaskoff, Marina, Fournier, Agnès, Mancini, Francesca Romana, Boeing, Heiner, Trichopoulou, Antonia, Peppa, Eleni, Karakatsani, Anna, Palli, Domenico, Grioni, Sara, Mattiello, Amalia, Tumino, Rosario, Fiano, Valentina, Onland-Moret, N Charlotte, Weiderpass, Elisabete, Gram, Inger T, Quirós, J Ramón, Lujan-Barroso, Leila, Sánchez, Maria-Jose, Colorado-Yohar, Sandra, Barricarte, Aurelio, Amiano, Pilar, Idahl, Annika, Lundin, Eva, Sartor, Hanna, Khaw, Kay-Tee, Key, Timothy J, Muller, David, Riboli, Elio, Gunter, Marc, Dossus, Laure, Trabert, Britton, Wentzensen, Nicolas, Kaaks, Rudolf, Cramer, Daniel W, Tworoger, Shelley S, and Terry, Kathryn L
- Published
- 2019
96. High levels of C-reactive protein are associated with an increased risk of ovarian cancer: Results from the Ovarian Cancer Cohort Consortium
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Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, Tworoger, Shelley S, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Peres, Lauren C, Mallen, Adrianne R, Townsend, Mary K, Poole, Elizabeth M, Trabert, Britton, Allen, Naomi E, Arslan, Alan A, Dossus, Laure, Fortner, Renée T, Gram, Inger T, Hartge, Patricia, Idahl, Annika, Kaaks, Rudolf, Kvaskoff, Marina, Magiocco, Anthony, Merritt, Melissa A, Quirós, J Ramón, Tjonneland, Anne, Trichopoulou, Antonia, Tumino, Rosario, van Gils, Carla, Visvanathan, Kala, Wentzensen, Nicolas, Zeleniuch-Jacquotte, Anne, and Tworoger, Shelley S
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- 2019
97. Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies
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UMC Utrecht Academie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Nichols, Hazel B., Schoemaker, Minouk J., Cai, Jianwen, Xu, Jiawei, Wright, Lauren B., Brook, Mark N., Jones, Michael E., Adami, Hans Olov, Baglietto, Laura, Bertrand, Kimberly A., Blot, William J., Boutron-Ruault, Marie Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Merritt, Melissa A., Milne, Roger L., Pala, Valeria, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Sund, Malin, Tamimi, Rulla M., Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R., Swerdlow, Anthony J., Sandler, Dale P., UMC Utrecht Academie, Epi Kanker Team 1, Cancer, JC onderzoeksprogramma Kanker, Nichols, Hazel B., Schoemaker, Minouk J., Cai, Jianwen, Xu, Jiawei, Wright, Lauren B., Brook, Mark N., Jones, Michael E., Adami, Hans Olov, Baglietto, Laura, Bertrand, Kimberly A., Blot, William J., Boutron-Ruault, Marie Christine, Dorronsoro, Miren, Dossus, Laure, Eliassen, A. Heather, Giles, Graham G., Gram, Inger T., Hankinson, Susan E., Hoffman-Bolton, Judy, Kaaks, Rudolf, Key, Timothy J., Kitahara, Cari M., Larsson, Susanna C., Linet, Martha, Merritt, Melissa A., Milne, Roger L., Pala, Valeria, Palmer, Julie R., Peeters, Petra H., Riboli, Elio, Sund, Malin, Tamimi, Rulla M., Tjønneland, Anne, Trichopoulou, Antonia, Ursin, Giske, Vatten, Lars, Visvanathan, Kala, Weiderpass, Elisabete, Wolk, Alicja, Zheng, Wei, Weinberg, Clarice R., Swerdlow, Anthony J., and Sandler, Dale P.
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- 2019
98. Reproductive and lifestyle factors and circulating sRANKL and OPG concentrations in women: Results from the EPIC cohort
- Author
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Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, Fortner, Renée T, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Sarink, Danja, Yang, Jiaxi, Johnson, Theron, Chang-Claude, Jenny, Overvad, Kim, Olsen, Anja, Tjonneland, Anne, Fournier, Agnes, Kvaskoff, Marina, Romana Mancini, Francesca, Boeing, Heiner, Trichopoulou, Antonia, Karakatsani, Anna, Valanou, Elissavet, Agnoli, Claudia, Sacerdote, Carlotta, Masala, Giovanna, Mattiello, Amalia, Tunino, Rosario, van Gils, Carla H, Skeie, Guri, Gram, Inger T, Weiderpass, Elisabete, Lujan-Barroso, Leila, Petrova, Dafina, Santiuste, Carmen, Quirós, J Ramón, Barricarte, Aurelio, Amiano, Pilar, Travis, Ruth C, Gunter, Marc J, Dossus, Laure, Christakoudi, Sofia, Kaaks, Rudolf, and Fortner, Renée T
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- 2019
99. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension: a population-based intervention trial from the Tromso Study
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Bonaa, Kaare H., Bjerve, Kristian S., Straume, Bjorn, Gram, Inger T., and Thelle, Dag
- Subjects
Fatty acids -- Measurement ,Hypertension -- Care and treatment - Abstract
Polyunsaturated fatty acids, which occur in fish oil and other foods, have been claimed to be beneficial for people with hypertension (high blood pressure). Eskimos have a high concentration of polyunsaturated fatty acid in their diet and they also have a low incidence of death from coronary heart disease, a disease of the coronary arteries, which supply blood to the heart itself. However, reports on blood pressure among Eskimos have been contradictory. Fish oil has appeared to lower blood pressure in some studies, but not in all. A carefully designed and controlled study was carried out on 156 mildly hypertensive residents of Tromsa, Norway, to observe the effects of diet on their blood pressure. They had undergone physical examinations, laboratory tests, and electrocardiographic exams. After an initial six-month observation period during which their dietary habits were monitored, subjects were randomly assigned to receive either fish oil components (eicosapentaenoic and docosahexaenoic acids, metabolic products of arachidonic acid breakdown) or corn oil (linoleic acid) in capsule form as supplements to their regular diet. Participants were examined after five weeks and again after 10 weeks. Complete dietary information was collected and evaluated for each subject. Changes in blood pressure, extent of fish consumption, and concentration of fatty acids in blood samples were recorded. Results showed that the subjects receiving fish oil had a significant reduction in systolic (4.6mm Hg), diastolic(3.0mm Hg), and average (3.5mm Hg) blood pressure values, while those taking corn oil had no changes. The subjects in both groups with a high fish intake had lower average blood pressure than those with low fish intake. The effect of fish oil on blood pressure was not significant, however, for subjects who ate the largest amount of fish, and for these subjects, too, their diet was found to account for two-thirds of the changes in blood levels of saturated and monounsaturated fatty acids. The component of fish oil that produced blood pressure reduction is not known, although eicosapentaenoic and docosahexaenoic acids worked for this group, and the effect on blood pressure was correlated with blood levels of eicosapentaenoic but not docosahexaenoic acid. It therefore seems likely that this was the effective component. Not all subjects receiving fish oil experienced lowered blood pressure (32 percent did not). The fattiness of the fish consumed in the diet was found to be a factor here; people who did lower their blood pressure ate less fatty fish. The results demonstrate that fish oil can lower blood pressure in people with mild hypertension. (Consumer Summary produced by Reliance Medical Information).
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- 1990
100. High Levels of C-Reactive Protein Are Associated with an Increased Risk of Ovarian Cancer: Results from the Ovarian Cancer Cohort Consortium
- Author
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Peres, Lauren C., primary, Mallen, Adrianne R., additional, Townsend, Mary K., additional, Poole, Elizabeth M., additional, Trabert, Britton, additional, Allen, Naomi E., additional, Arslan, Alan A., additional, Dossus, Laure, additional, Fortner, Renée T., additional, Gram, Inger T., additional, Hartge, Patricia, additional, Idahl, Annika, additional, Kaaks, Rudolf, additional, Kvaskoff, Marina, additional, Magliocco, Anthony M., additional, Merritt, Melissa A., additional, Quirós, J. Ramón, additional, Tjonneland, Anne, additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, van Gils, Carla H., additional, Visvanathan, Kala, additional, Wentzensen, Nicolas, additional, Zeleniuch-Jacquotte, Anne, additional, and Tworoger, Shelley S., additional
- Published
- 2019
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