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3,539 results on '"González-Marcos, A."'

54. Measuring Computational Thinking -- Adapting a Performance Test and a Self-Assessment Instrument for German-Speaking Countries

Author

Guggemos, Josef, Seufert, Sabine, and Román-González, Marcos

Abstract

Far-reaching technological changes are shaping our society and the ways in which we work. A key 21st -century skill for taking advantage of those changes may be computational thinking (CT). CT aims at enabling humans to carry out more effective problem solving by utilizing concepts of computing and computer technology. For a successful integration of CT into curricula, however, it is important to take assessment into account. We review two instruments that capture CT: the Computational Thinking Test (CTt), a performance test, and the Computational Thinking Scales (CTS), that relies on self-assessment. We have adapted both instruments from English to German. Using a sample of 202 upper-secondary students from Switzerland, we provide further evidence on the validity of both instruments. To this end, we apply item response theory and confirmatory factor analysis. Furthermore, we evaluate the relationship between CTt and CTS. Both instruments show good properties and may be suitable for assessing CT in German-speaking countries at the secondary level. [For the complete proceedings, see ED608557.]

Published
2019

55. Is the PPG signal chaotic?

Author

de Pedro-Carracedo, Javier, Fuentes-Jimenez, David, Ugena, Ana M., and Gonzalez-Marcos, Ana P.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Physics - Medical Physics, I.5.4, J.3
Abstract

This paper shows how the dynamics of the PhotoPlethysmoGraphic (PPG) signal, an easily accessible biological signal from which valuable diagnostic information can be extracted, of young and healthy individuals performs at different timescales. On a small timescale, the dynamic behavior of the PPG signal is predominantly quasi-periodic. On a large timescale, a more complex dynamic diversity emerges, but never a chaotic behavior as earlier studies had reported. The procedure by which the dynamics of the PPG signal is determined consists of contrasting the dynamics of a PPG signal with well-known dynamics---named reference signals in this study---, mostly present in physical systems, such as periodic, quasi-periodic, aperiodic, chaotic or random dynamics. For this purpose, this paper provides two methods of analysis based on Deep Neural Network (DNN) architectures. The former uses a Convolutional Neural Network (CNN) architecture model. Upon training with reference signals, the CNN model identifies the dynamics present in the PPG signal at different timescales, assigning, according to a classification process, an occurrence probability to each of them. The latter uses a Recurrent Neural Network (RNN) based on a Long Short-Term Memory (LSTM) architecture. With each of the signals, whether reference signals or PPG signals, the RNN model infers an evolution function (nonlinear regression model) based on training data, and considers its predictive capability over a relatively short time horizon., Comment: 23 pages, 12 figures, 34 subfigures

Published
2020
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56. From Best Hits to Best Matches

Author

Stadler, Peter F., Geiß, Manuela, Schaller, David, Sánchez, Alitzel López, González, Marcos E., Valdivia, Dulce I., Hellmuth, Marc, and Rosales, Maribel Hernández

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Many of the commonly used methods for orthology detection start from mutually most similar pairs of genes (reciprocal best hits) as an approximation for evolutionary most closely related pairs of genes (reciprocal best matches). This approximation of best matches by best hits becomes exact for ultrametric dissimilarities, i.e., under the Molecular Clock Hypothesis. It fails, however, whenever there are large lineage specific rate variations among paralogous genes. In practice, this introduces a high level of noise into the input data for best-hit-based orthology detection methods. If additive distances between genes are known, then evolutionary most closely related pairs can be identified by considering certain quartets of genes provided that in each quartet the outgroup relative to the remaining three genes is known. \emph{A priori} knowledge of underlying species phylogeny greatly facilitates the identification of the required outgroup. Although the workflow remains a heuristic since the correct outgroup cannot be determined reliably in all cases, simulations with lineage specific biases and rate asymmetries show that nearly perfect results can be achieved. In a realistic setting, where distances data have to be estimated from sequence data and hence are noisy, it is still possible to obtain highly accurate sets of best matches. Improvements of tree-free orthology assessment methods can be expected from a combination of the accurate inference of best matches reported here and recent mathematical advances in the understanding of (reciprocal) best match graphs and orthology relations.

Published
2020

57. Mindchanger identification, analysis and recognition: youth perceptions

Author

Fermín Navaridas-Nalda, Ana González-Marcos, Esther Raya-Díez, and Ana María Vega-Gutiérrez

Subjects
Sustainability, youth participation, engagement, global awareness, active citizenship, Special aspects of education, LC8-6691, The family. Marriage. Woman, HQ1-2044
Abstract

ABSTRACTYouth participation and activism are considered key factors in making the world a fairer, more inclusive, and sustainable place. In line with this idea, in this work, we aim to understand how young people who actively participate in social organizations perceive the characteristics that define young ‘mindchangers.’ By this concept, we refer to a young citizen who is committed to social justice and willing to change society’s mindsets and catalyse active participation among their peers. In our research design, we adopted a quantitative methodological approach using a survey procedure. The results reveal a high level of agreement on the traits that define a Mindchanger. We conclude by emphasizing that the characteristics to which young respondents attribute the highest importance, such as ‘promoter of change’, ‘open-minded’, ‘interest in global issues’, ‘open to international solidarity’ and ‘empathy’, appear to have the greatest influence on the likelihood of becoming a Mindchanger.

Published
2023
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61. Phase space reconstruction from a biological time series. A PhotoPlethysmoGraphic signal a case study

Author

de Pedro-Carracedo, J., Ugena, A. M., and Gonzalez-Marcos, A. P.

Subjects
Quantitative Biology - Other Quantitative Biology, Electrical Engineering and Systems Science - Signal Processing, Nonlinear Sciences - Adaptation and Self-Organizing Systems, 37-02, 37E99
Abstract

In the analysis of biological time series, the state space comprises a framework for the study of systems with presumably deterministic properties. However, a physiological experiment typically captures an observable, or, in other words, a series of scalar measurements that characterize the temporal response of the physiological system under study; the dynamic variables that make up the state of the system at any time are not available. Therefore, only from the acquired observations should state vectors reconstructed to emulate the different states of the underlying system. It is what is known as the reconstruction of the state space, called phase space in real-world signals, for now only satisfactorily resolved using the method of delays. Each state vector consists of m components, extracted from successive observations delayed a time t. The morphology of the geometric structure described by the state vectors, as well as their properties, depends on the chosen parameters t and m. The real dynamics of the system under study is subject to the correct determination of the parameters t and m. Only in this way can be deduced characteristics with true physical meaning, revealing aspects that reliably identify the dynamic complexity of the physiological system. The biological signal presented in this work, as a case study, is the PhotoPlethysmoGraphic (PPG) signal. We find that m is five for all the subjects analyzed and that t depends on the time interval in which it evaluates. The H\'enon map and the Lorenz flow are used to facilitate a more intuitive understanding of applied techniques., Comment: 12 pages, 12 figures with 37 subfigures

Published
2019
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62. Dynamical analysis of biological signals with the 0-1 test

Author

de Pedro-Carracedo, J., Ugena, A. M., and Gonzalez-Marcos, A. P.

Subjects
Electrical Engineering and Systems Science - Signal Processing, Nonlinear Sciences - Chaotic Dynamics
Abstract

The 0-1 test distinguishes between regular and chaotic dynamics for a deterministic system using a time series. Here is presented how to use the test with biological signals. Between all the biological signals obtained as a times series, we present the results of applying the test and study with more details the photoplethysmogram (PPG) from different subjects; different biological signals of one subject are analyzed also with the test. PPG signal contains extensive physiological dynamics information; mainly used to heart rate monitoring and blood oxygen saturation. Based on its understandable statistics, several indices have been proposed and may apply to some clinical needs. However, continuous real-time monitoring, of the non-stationary biological signals, is frequently used on the modern intensive care unit. A deep understanding of the PPG signal will allow finding algorithms to evaluate other possible indices that give information about the dynamical system that constitutes the human body. We demonstrate that the PPG signal, as a time series, on a healthy individual, is a quasi-periodic signal. The parameters calculated for the analysis give some ideas of what the quasi-periodic properties mean. Results are on PPG signals from different healthy young people. The dynamical analysis of the PPG signal applying the 0-1 test allows distinguishing a regular dynamic, periodic o quasi-periodic, from a chaotic dynamics operating directly over the time series. The result obtained is compared with the results from well known time series that are random, chaotic, aperiodic, periodic, and quasi-periodic., Comment: 8 pages, 3 figures with 40 subfigures

Published
2019
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63. Best Match Graphs and Reconciliation of Gene Trees with Species Trees

Author

Geiß, Manuela, González, Marcos E., Sánchez, Alitzel López, Valdivia, Dulce I., Hellmuth, Marc, Rosales, Maribel Hernández, and Stadler, Peter F.

Subjects
Quantitative Biology - Populations and Evolution, Computer Science - Discrete Mathematics
Abstract

A wide variety of problems in computational biology, most notably the assessment of orthology, are solved with the help of reciprocal best matches. Using an evolutionary definition of best matches that captures the intuition behind the concept we clarify rigorously the relationships between reciprocal best matches, orthology, and evolutionary events under the assumption of duplication/loss scenarios. We show that the orthology graph is a subgraph of the reciprocal best match graph (RBMG). We furthermore give conditions under which an RBMG that is a cograph identifies the correct orthlogy relation. Using computer simulations we find that most false positive orthology assignments can be identified as so-called good quartets -- and thus corrected -- in the absence of horizontal transfer. Horizontal transfer, however, may introduce also false-negative orthology assignments.

Published
2019

67. Circularly symmetric nanopores in 3D femtosecond laser nanolithography with burst control and the role of energy dose

Author

Paz-Buclatin Franzette, Esquivel-González Marcos, Casasnovas-Melián Alfredo, de Varona Omar, Cairós Carlos, Trujillo-Sevilla Juan Manuel, Kamada Kei, Yoshikawa Akira, Rodríguez-Ramos Jose Manuel, Martin Leopoldo Luis, and Ródenas Airan

Subjects
3d laser writing, 3d nanofabrication, 3d nanolithography, 3d nanophotonics, laser nanostructuring, nanofabrication, Physics, QC1-999
Abstract

The fabrication of three-dimensional (3D) nanostructures within optical materials is currently a highly sought-after capability. Achieving nanoscale structuring of media within its inner volume in 3D and with free design flexibility, high accuracy and precision is a development yet to be demonstrated. In this work, a 3D laser nanolithography technique is developed which allows producing mm-long hollow nanopores inside solid-state laser crystals and with a high degree of control of pore cross-sectional aspect ratio and size. We report an in-depth study on the formation of pores both within the non-thermal regime at which temperature is fast dissipated after each laser pulse, and for a thermally controlled regime using pulse-bursts which facilitate the formation of pores with highly circular shapes down to 1.1. We demonstrate this process for a wide range of speeds, pulse repetition rates and pulse energies, thus opening the door to a much more useful nanofabrication technique for nanophotonics. Finally, we also report the change in index of refraction that is produced at the nanoscale obtaining a positive index contrast of ∼3%. The work therefore provides a promising path towards reliable 3D nanostructuring of solid-state laser media for the flexible fabrication of large and complex structures with features sizes from the nanoscale up to the mm-scale. Moreover, due to the embedded, seamless, and monolithic nature of this technology, and since YAG crystals can sustain temperatures of up to 1900 °C and are highly chemically inert and erosion resistant, we anticipate its direct application in harsh environments.

Published
2023
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73. Integrated flow cytometry and sequencing to reconstruct evolutionary patterns from dysplasia to acute myeloid leukemia

Author

Simoes, Catia, Chillon, Maria-Carmen, Martínez-Cuadrón, David, Calasanz, Maria-José, Vridiales, María-Belén, Vazquez, Iria, Hernández-Ruano, Montserrat, Ariceta, Beñat, Aguirre-Ruiz, Paula, Burgos, Leire, Alignani, Diego, Sarvide, Sarai, Villar, Sara, Pierola, Ana Alfonso, Prosper, Felipe, Ayala, Rosa, Martínez-López, Joaquin, Bergua Burgues, Juan Miguel, Vives, Susana, Perez-Simon, Jose A., Garcia-Fortes, Maria, Bernal del Castillo, Teresa, Colorado, Mercedes, Olave, Mayte, Rodríguez-Gutiérrez, Juan I., Labrador, Jorge, González, Marcos, San-Miguel, Jesús F., Sanz, Miguel Ángel, Montesinos, Pau, and Paiva, Bruno

Published
2023
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74. Wine corks decontamination using plasma activated water

Author

Sainz-García, Ana, González-Marcos, Ana, Múgica-Vidal, Rodolfo, Muro-Fraguas, Ignacio, Gallarta-González, Félix, González-Arenzana, Lucía, López-Alfaro, Isabel, Santamaría, Pilar, Escribano-Viana, Rocío, Sainz-García, Elisa, and Alba-Elías, Fernando

Published
2023
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79. Best Match Graphs

Author

Geiß, Manuela, Chavez, Edgar, Gonzalez, Marcos, Lopez, Alitzel, Stadler, Bärbel M. R., Valdivia, Dulce I., Hellmuth, Marc, Rosales, Maribel H., and Stadler, Peter F.

Subjects
Mathematics - Combinatorics
Abstract

THIS IS A CORRECTED VERSION INCLUDING AN APPENDED CORRIGENDUM. Best match graphs arise naturally as the first processing intermediate in algorithms for orthology detection. Let $T$ be a phylogenetic (gene) tree $T$ and $\sigma$ an assignment of leaves of $T$ to species. The best match graph $(G,\sigma)$ is a digraph that contains an arc from $x$ to $y$ if the genes $x$ and $y$ reside in different species and $y$ is one of possibly many (evolutionary) closest relatives of $x$ compared to all other genes contained in the species $\sigma(y)$. Here, we characterize best match graphs and show that it can be decided in cubic time and quadratic space whether $(G,\sigma)$ derived from a tree in this manner. If the answer is affirmative, there is a unique least resolved tree that explains $(G,\sigma)$, which can also be constructed in cubic time.

Published
2018
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83. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Author

Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, 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Quintana-Villamandos, Begoña, Tousidonis, Manuel, Marin, Florencio M, Garcia, Pablo Rodriguez, Freiria Eiras, Miguel A, Vallve-Bernal, Marc, Bleda, Silvia, De Haro, Joaquin, Troncoso, Paula, Martín del Olmo, Juan C, Gómez-López, Juan R, Domínguez, Melody García, Morales-Puebla, Jose M, López-García, Isabel, Escartin, Jorge, El-Abur, Issa Talal, Aguilera, David García, Martin-Sole, Oriol, Pérez-Bertólez, Sonia, de Haro Jorge, Irene, Corres, Oscar Izquierdo, Mora-Guzmán, Ismael, Oliver Guillen, Jose R, de-Fernandez, Alina Lopez, San-Jose, Beatriz Fernandez-Velilla, Bergkvist, David Julià, Ruiz-Villa, Laura, Marín, Eduardo González, Melero, Alba Vázquez, Varela, Lorena, Calvo, Mikel Prieto, Ateca, Ibabe Villalabeitia, Perfecto, Arkaitz, Carnicero, Patricia Alonso, Aranda, Elena, Martin-Playa, Patricia, Elizalde, Leire Aparicio, Galvañ, Yaiza, Plata-Bello, Julio, Fernández-Fernández, June, Rahy-Martín, Aida C, Rosas-Bermúdez, Clara, Pelloni, Maria, Di Martino, Marcello, Pendolero, Jorge Prada, Pérez, David Díaz, Losada, Manuel, García-Conde, María, Diéguez, Beatriz, Hernandez-Garcia, Miguel, Vidal, Francisco Ripoll, Zabaleta, Jon, Barrueco, Alvaro Sánchez, Beltran-Miranda, Pablo, Guevara-Martínez, Jenny, Arteaga Asensio, Pablo C, Saudí, Sef, Jariod-Ferrer, Ursula M, Duque-Mallén, Maria V, Dobon, Miguel A, Gracia-Roche, Carlos, Mendoza-Moreno, Fernando, Palacios, Nelson Morales, Diez-Alonso, Manuel, Matías-García, Belen, Diego, Lucía, Blázquez-Martin, Alma, Burgos-Blasco, Patricia, Ramos, Diego, Berna-Rico, Emilio, Ley, Luis, Sánchez-Fernández, Fátima, Río-Arroyo, Laura Del, Barberá, Rafael, Sánchez, Alberto Cabañero, Barranquero, Alberto G, Montes-Jovellar, Lourdes, Tejero-Pintor, Francisco J, Estévez, Javier Mata, Colás-Ruiz, Enrique, Gomez-Perez, Beatriz, Moya-Angeler, Joaquin, Delegido, Ana, Vázquez, Pedro José Gil, Alconchel, Felipe, León-Muñoz, Vicente J, López, Tatiana Nicolás, Pintor-Tortolero, Jose, Tallon-Aguilar, Luis, Dios-Barbeito, Sandra, Capitán, Luis C, 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Abdallah, Muneeb E, Shaar, Abdalkader, shaar, Mohamed Nafea, kora, Mohamad khaled, Muhmmed, Khadija Ala, Sarih, Monira Mohammed, Omer, Mohammed E A, Idris, Moyasar A, Osman, Osama S, Alawad, Elharith MA, Ebad, Mustafa Abdalla Bakhit, Ibrahim, Ahmed M, Abass, Khider Altayeb Bakheet, Nour, Alshareef Bakri Yousif Mohamed, Hamid, Hytham K S, Ahmed, Khabab Abbasher Hussien Mohamed, Ibrahim, Mohja Elsheikh Obeid, Yassin, Abubaker M, Abdelrahman, Salma Esam Mohamed Elhassan, Alnaser, Adnan Ayman, Taha, Tarig M, Adam, Mohammed E A E, AAhmed, Abdelkareem, Ebad, Mustafa Abdalla bakhit, Saadelnour, Mohammed Ahmed Idrees, Adlan, Ali Mohamed Ahmed, Ismail, Azzain, Alkhalifa, Elmustafa, Abdalaal, Ibrahim Ali Mohamed, Fadalla, Tarig, Ibrahim, Mohamed Yahia, Hamdoun Aziz, Elaf A, Mohammed, Muhsin Mohammed E A, Mohamed, Tasneem A, Alhag, Ali Alsaeed Ali, Mohamed, Rayan Ibrahim Hamid, Hamza, Salih Boushra, Ali, Mohamed Abdelazim Mohamed, Ahmed, Nidal Youseef A A, Alhag, Albrra Alhag Mohamed, Saleh, 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Takahji, Mohammad Eyad, Hasan, Zein Fouad, Abduljalil, Aalaa, MAlhalabi, Nawras, Al Jammal, Mohamad Basher A, Alia, Diana N, Homsi, Muhannad, Masri, Joseph, Masri, Ruqaya J, Toutounji, Tayf, Al Aliwy, Marwan, Kabbani, Nasrullah, Kadoura, Lama, Sultan, Dana, Kassem, Luma Haj, Al-Naeb, Houmam Mohamad, Al-Hajjaj, Maher M, Alkhaleel, Wael, Swed, Sarya, Naal, Mohammad Yusuf, Tfankji, Salim, Almohammed, Mohammad Husein Rajab, Nabhan, Mohammad Hassan, Al-Mouakeh, Ahmad, Najjar, Mahfoud M, Alhashash, Ahmad, Ghazal, Ahmad, Alchallah, Mhd Obai, Alolabi, Homam, ElHomsi, Muhammad Omar, Rayes, Omar, Naem, Antoine, Al-Houssami, Salma MHD Mazen, Gawrieh, Bardisan S, Hamdan, Alaa, Hassan, Naya Talal, Hammed, Ali M, Elias, Elias George, Ahmad, Aline Ali, Knifaty, Mohammed Amr, Moussa, Ahmed M, Yabasin, Iddrisu Baba, Roan, Jun-Neng, Shih, Chao-Jung, Chen, Po Chuan, Lohsiriwat, Varut, Phupong, Vorapong, Techapongsatorn, Suphakarn, Lalchan, Avery M, Charles, Shane, Rim, Bouchahda, Bouhani, Malek, Ghalleb, Montassar, Chamakhi, Amine, Sebai, Amine, dahman, Nesrine Ben hadj, Ammar, Houssem, Said, Mohamed Amine, Kechiche, Nahla, Aghayeva, Afag, Dülgeroğlu, Onur, Ozben, Volkan, Aytac, Erman, Atasoy, Deniz, Arikan, Akif Enes, Kara, Halil, Dogan, Nasuh U, Bostanci, Asli, Turhan, Murat, Ozkan, Ozlenen, Dumlu, Ersin G, Menekşe, Ebru, Oter, Volkan, Piskin, Erol, Hasirci, Ismail, Colakoglu, Muhammet Kadri, Bostanci, Erdal Birol, Ozgun, Yigit Mehmet, Girgin, Behic, Erel, Serap, Demirel, Sibel, Yanik, Özge, Gecim, Ibrahim Ethem, Koc, Mehmet Ali, Akyol, Cihangir, Güner, Volkan, Konca, Can, Batioğlu, Figen, Hakseven, Musluh, Toptas, Tayfun, Aydin, Yener, Ulas, Ali B, Ince, Ilker, Altinel, Yuksel, Demirgan, Serdar, Meric, Serhat, Sevdi, Mehmet Salih, Ercetin, Candas, Ferahman, Sina, Aydin, Husnu, Dural, Ahmet Cem, Sahbaz, Nuri A, Yalkin, Omer, Sen, Murat, Isik, Ozgen, Yilmazlar, Ahmet Tuncay, Bisgin, Tayfun, Yigit, Banu, bayhan, Hüseyin, Buldanli, Mehmet Z, Gultekin, Murat, Cennet, Omer, Unal, Ertekin U, Çakici, Mehmet Çağlar, Iplikci, Ayberk, Yildirim, Asif, Ozgur, Ilker, Sen, Comert, Dincer, Muserref B, Erginöz, Ergin, Sanli, Ahmet Necati, Turna, Akif, Askar, Ahmet, Uludağ, Server Sezgin, Guldogan, Cem E, Ozmen, Mehmet M, Bozkurt, Mehmet A, özcan, Adem, Kara, Yasin, Kocataş, Ali, Guner, Ali, Sari, Ramazan, Memisoglu, Ecem, Saracoglu, Kemal T, Tosun, Yasin, Çetin, Kenan, Kalafat, Erkan, Taskiran, Cagatay, Vatansever, Dogan, Giray, Burak, Tatar, Ozan C, Köksal, Hande, Özkent, Mehmet Serkan, Ulutaş, Mehmet E, Hamarat, Mustafa B, Coskun, Bora, Abbasov, Aykhan, Altinsoy, Ezgi, Uprak, Tevfik Kivilcim, Saracoglu, Ayten, Ugurlu, M Umit, Kose, Emin, Ozgen, Utku, Sungurtekin, Ugur, Gonullu, Emre, Bayhan, Zulfu, Akin, Emrah, Mantoglu, Baris, Colak, Elif, Kucuk, Gultekin Ozan, Yuksel, Cemil, Aydin, Ferit, Dogan, Lutfi, Culcu, Serdar, Tufan, Aydin Eray, Citgez, Bulent, Akpinar, Göksever, Köksoy, Ülkü C, Ulgur, Hanife Seyda, Kalin, Murat, Ozkan, Omer Faruk, Yildirak, Muhammed Kadir, Atici, Semra Demirli, Salimoğlu, Semra, Abud, Burcin, Calik, Bulent, Kamer, Erdinc, Kebabci, Eyup, Uylas, Ufuk, Teker, Kenan, Cakmak, Guldeniz Karadeniz, Gultekin, Fatma Ayca, Xaviour, Okedi Francis, Isaac, Otolia, Gaston, Turinawe, Asiimwe, Daniel, Vahwere, Bienfait Mumbere, Sikakulya, Franck Katembo, Lule, Herman, Lugobe, Henry Mark, Lekuya, Hervé Monka, Namugenyi, Christine, Kiweewa, Ronald, Bosco, Muhangi, Yovenko, Ihor, Kopetskyi, Viacheslav, Maksymenko, Bogdan, Khan, Sabina A, Padvi, Amit Vasantrao, Serour, Mohamed A, Beigh, Shamim Ahmad, Elsayed, Hisham M, Mohamed, Awadelkarim O, Basappanavar, Vikram Somashekhar, Al-Wandi, Amna S, Khalil, Kareem S, Younis, Muhammad Umar, Al Saadi, Hayder S Abdulhadi, Heidan, Ginan K, Trehan, Ravi K, Davies, Justin, Ashcroft, James, Georgiades, Fanourios, Durrani, Amer J, Price, Stephen J, Wong, Kai Yuen, Agrawal, Amit, Seah, Matthew KT, Saad, Marwa M E, Segaren, Nicholas, Ghobrial, Marios, Balakrishnan, Anita, Forouhi, Parto, Khan, Wasim S, Wheeler, James, Schache, Andrew G, Katsikostas, Dimitrios P, Angelou, Dimitrios, Fell, Adam J, Madani, Rana, Dindyal, Shiva, Seraj, Shaikh S, Sharavanan, Premalatha, Iqbal, Muhammad R, Wong, Nicholas J, Lo, William B, Soon, Wai C, Hammouche, Dalia, Lee, Jonathan DE, Pachl, Max J, Alexander, Dinesh, Ahmad, Shoaib, Morley, Hannah L, Selwyn, David, Wareing, Jonathan, Oktseloglou, Vlasios, Bobak, Peter, Rampersad, Lisa S, Mohamed, Mazin, Kaur, Mandeep, Athanasiou, Antonios, Martin, Benjamin P, Jichi, Tarik S, Batchelor, Tim JP, Rozwadowski, Sophie, Maniarasu, Sarveen, Seyed-Safi, Parisah K, Kutuzov, Vladislav, Shah, Hemina B, Noton, Toby M, Dela Cruz, Nina Jyne Minette, Trehan, Neev, Tokidis, Evripidis, Byrne, Matthew H V, Winter, Stuart C, Pinto-Lopes, Rui, Pavithran, Aswathy, Khalifa, Ahmad O, Eardley, Nicola J, Ashour, Rami, Steinke, Jacqueline D, Esmail, Husayn D, Bence, Matthew N, Walters, Samuel T, Akinyemi, Tosin O, Lakpriya, Sathya, Moawad, Nader N, Panahi, Pedram, Lau, Joshua, McAleer, Stephen, Laoye, Adeyinka, Hussain, Abdulzahra Abdulsamad, Zafar, Muneeb, Elsheikh, Mohammed H, Shaerf, Daniel A, Soggiu, Fiammetta, Massoumi, Abaris, Gareb, Fahed, Yao, Mark W, Qamar, Mubasher A, Fang, Clarissa E H, Greenhalgh, Michael S, Hunt, Alexander, Oladeji, Emmanuel O, Benjamin, Miles W, Beak, Philip, Rae, Fraser J, Aithie, Joanna M S, Clarke, Gareth W J, Veeramootoo, Darmarajah, Ashman, Alex J, Kahka, Ehab E, Rafe, Tanvir, PATEL, PANNA K, Albirnawi, Hatim, Katory, Mark, Fisher, Ann, Amonkar, Sunil J, Rao, Pawan Kumar Dhruva, Holroyd, David J, Gkikas, Andreas, Newton, Lydia S, Kirk, Alan J B, Khalid, Ayesha, Ferguson, David, Stanier, Paul B, Shah, Vinay, El-Boghdadly, Kariem, Schizas, Alexis M P, ilyas, Minahi, George, Mark L, Gawad, Mothana, Groom, William D, Al-Azzawi, Mohammed, Ahluwalia, Julian CJ, Punjabi, Prakash P, Cheung, Fang Yi, Wilson, Michael D, Mitrofan, Claudia Gabriela, Malam, Yogeshkumar, Townson, Adam, Loubani, Mahmoud, Yau, Jih Dar, Seebah, Kevin, Akowuah, Enoch F, Pushpoth, Sreekumari R, Viswanath, Yirupaiahgari KS, ElSanhoury, Kareem, Chew, Misha, Walker, Thomas E, Elhassan, Almutasim Billah Elbagir, Belcher, Elizabeth, Goricar, Matej, majd, Hooman Soleymani, Knight, Dominic, Ismail, Lamiese, McKinnon, Chris, Ganau, Mario, Prokopenko, Max, Doshi, Neel S, Gkorila, Aikaterina, Sheikh, Nomaan A, Helm, Jessica R, Low, Mei Ken, Ogunfusika, Oluseyi Harold, Bisheet, George, Alhammali, Tariq, Arnob, Ahmed Showki, Singh, Jatinder, Allde, Emma L, Sambhwani, Sharan H, Dube, Manas, Gemmill, Elizabeth H, John, Joby, Gerogiannis, Ioannis N, Abuelgasim, Mona A A, Crate, Georgina, Holme, Thomas J, Nguyen, Anh T V, Ho, Michael W, Wade, Ryckie G, Hussain, Azar, Andrzejowski, Paul, Omakobia, Eugene, Eltayeb, Momin, Galabov, Tsanko P, Lee, Chung Yan Vernon, Nazir, Anum, Siaw, Oliver L, Ashford, Robert U, Boddy, Alex P, Ashmore, Christopher D, Shah, Snehadhar M, Gowers, Benjamin T V, Thekkinkattil, Dinesh K, Worku, Dawit, Harky, Amer, Talwar, Rishi, Sagoo, Harkiran K, Jambulingam, Periyathambi S, Smart, Christopher J, Doherty, Daniel T, Mastoridis, Sotiris, Kumar, Sidharth, Mahmoud, Rana, Solari, Francesca, Egan, Richard J, Barry, Jonathan D, Morrison, Jo, Davoudi, Kaveh, Hollyman, Marianne, Kelly, Andrew, Badenoch, Thomas F, pandanaboyana, sanjay, Critchley, Rebecca J, Sarodaya, Varun R, Sinnerton, Robert J H, Manickavasagam, Jaiganesh, Lindsay, Elizabeth F, Arora, Ankita, Hasan, Raashad, Liew, Ignatius, Ozua, Joshua, Kouritas, Vasileios, Collins, Rachael V, Lafford, George H, Moret, Charlie, Chean, Chung Shen, Horgan, Liam F, Aujayeb, Avinash, Siddique, Muhammad Harris, Navaratne, Lalin, Kotecha, Sanjeev, Bellato, Vittoria, Lewis, Sophia E, Ali, Muhammad Usman, Marson, Ben A, Craxford, Simon, Gajjar, Ketankumar, Theophilidou, Elena, Aboelmagd, Tariq, Khatkar, Harman, Awadallah, Mahmoud A, Blanco, Jose A, Chituku, Tsitsi G, Dixon, Oliver GB, sarveswaran, Janahan, Jones, Imogen S, Hammouche, Salah, Vijay, Vardhini, Ooi, Rucira, Karmarkar, Rahi, Khaleeq, Tahir, Bhatia, Mohit, Al-Khazaali, Badr L, Daadipour, Audrina, Mattar, Ahmed, Singhal, Tarun, Mahmoud, Moustafa Ibrahim, Glasbey, James, Nankivell, Paul C, Kalkat, Maninder S, Nour, Shahd, Beggs, Andrew D, Yershov, Danylo Y, Chughtai, Shafiq Ahmad, Youssef, Hesham, Norrish, Alan R, Mohammed, Mohammed M, Gwozdz, Adam M, Charalambous, Michalis P, Knight, Stephen R, McCaul, James A, Bridgman, Elsie A, El Sheikh, Mustafa, Ogunbowale, Akinsola, Wright, Evan O, Ahmed, Usama, Younus, Hafsa, Tincknell, Laura G, Weixing-Ho, Ken, Demetriou, Charis, Hussei, Mohammed, Reilly, John-Joe, Hormis, Anil P, Moug, Susan J, Anazor, Fitzgerald C, Horwell, Edward A, Neal-Smith, Gregory, McNamara, John M, Baryeh, Kwaku W, Bhatti, Khalid M, McKay, Joseph E, Cannoletta, Maria G, Perkins, Clare J, Gopalswamy, Sivakumar, Sheldon, Anna F, John, Joseph B, Mantle, Mark, Toia, Bogdan, Phillips, Andrew J, Al-Khyatt, Waleed, Lund, Jonathan N, Ammar, Ahmed Y, Yim, Guang H, Huntley, Daniel A, Daniels, Ian R, Valverde, Joao, Lumley, Edward David John, Walton, Thomas J, Raptis, Dimitri A, Dimitrokallis, Nikolaos, Nathan, Arjun, Motallebzadeh, Reza, Chowdhury, Shihab, Ahmed, Rezwan F A, Mirnezami, Reza, Szakmany, Tamas, Knight, Dominic J, Al-Azzani, Waheeb, Davies, Huw R, Ooi, Setthasorn Zhi Yang, Oo, Khaing K, Cullis, Paul S, Peng, Ed, Demetriades, Andreas K, Tambyraja, Andrew L, Poon, Michael TC, Brennan, Paul M, Oikonomou, Dimitrios, Newman, Samuel E, Le Blevec, Louise, Otify, Mohamed, Szatmary, Peter, Devkaran, Bhavesh, Sochorova, Dana, Sohrabi, Catrin, Sivaprakasam, Rajesh, Goh, Mingzheng Aaron, Atkinson, Kate V, Soares, Delvene, Prce, Daniela, Cann, Johnathon P, Grobbelaar, Amy C, Bradley, Rebecca, Strauss, Helen J, Taha, Ahmed, Minicozzi, Annamaria, Thakur, Bhaskar, Hanoun, Abdullah, Goru, Poornanand, Baumber, Rachel M, Sobti, Anshul S, Cross, George WV, Havenhand, Tom, Antoniou, George A, Chauhan, Govind Singh, Vokshi, Ismail, Mahmud, Ayesha, Albanese, Erminia, Evans, Daisy, Madhuri, Thumuluru Kavitha, Horsnell, Jonathan D, Zalmay, Pardis, Davies, Angharad J, Aljanadi, Firas, Jeganathan, Reubendra, Jones, Mark, Kakos, Christos, vidya, Raghavan, El-Ghobashy, Alaa, Habib, Ahmed M, Reid, Jeremy P, Rajgor, Harshadkumar Dhirajlal, Ahmed, Omar, Branagan, Graham, Mohamedahmed, Ali Yasen Y, Al-Sabbagh, Ali, Chetty, Govind, Kelty, Clive J, EL-Wajeh, Yasin A M, Tomlinson, James E, Rominiyi, Ola, Sinha, Saurabh, Saad, Sanad, Sahu, Banchhita, Charalampakis, Vasileios, Enemosah, Ibrahim, Williams, Simon J, Yaqoob, Hassan N, Laurent, Edward P, Moreau, Joshua L, Frostick, Rhiannon, Parwaiz, Hammad, Aboelmagd, Karim, Pournaras, Dimitri J, Hristova, Kalina H, Iyengar, Karthikeyan P, Mohamed, Muyed, Artioukh, Dmitri Y, Anwar, Sibtain, Hussein, Mostafa K A, Omogbehin, Tomisin S, Herron, Jonathan B T, Labib, Amir, Patel, Preemal, Marsden, Samuel C, Mehdian, Roshana, Santhirakumaran, Gowthanan, Smelt, Jeremy, Agarwal, Ketan, Lancerotto, Luca, Sahnan, Kapil, Shalhoub, Joseph, Donnelly, Liam J, Erridge, Simon, Chidambaram, Swathikan, Luo, Xun, Bansal, Sujesh, Ryan, Neil AJ, Smith, Alexander C D, Flatman, Michael, Wafaie, Imad, Malik, Muhammad Isfandyar Khan, Thumbadoo, Ruben P, Hussain, Shoaib F, Henein, Christin, Hamad, Yousif T, Belgaumkar, Ajay P, Bosanquet, David C, Kolias, Angelos G, Choi, David, Marcus, Hani J, Horsfall, Hugo RM Layard, Khan, Danyal Z, Sahni, Arun, Millward, Christopher P, Render, Luke, Truss, Adam, Elmoslemany, Tarek, Parmar, Chetan, Hanger, Joseph, Sheen, Jonathon, Rait, Jaideep S, Foreman, Jennifer, Marzouqa, Natalie, Fontalis, Andreas, Voulalas, Grigorios, CHEONG, Ryan Chin Taw, Dindyal, Sanjay, Arumugam, Sathyaseelan, Ward, Thomas R W, Stephens, Alastair S, Douka, Eleftheria, Abou-Foul, Ahmad K, McKay, Siobhan C, Kitchen, Mark O, Rees-Stoner, Oliver DJ, Balasubramanya, Supriya, Akhtar, Muhammad Adeel, Warwick, Andrew J, Pawar, Shweta, Dubey, Vivek, Al-Yaseen, Mustafa W, Williams, Christopher YK, Laird, Alexander, Krishna, Kandaswamy, Anyaugo, Ngozi S, Wuraola, Obafemi K, Odejinmi, Funlayo, Craven, Joanna M, West, Charlotte L, Barter, Reece A, Navaratnam, Devaraj M, Malik, Shahbaz S, Mahendran, Vimaladhithan, Zilvetti, Miguel, Lovegrove, Richard E, Board, Tim N, Zeiton, Moez, Sarwar, Safdar A, Duff, Sarah E, Hsabo, Elmuiz A, Nugur, Ashwani Kumar, Morris, Richard M, Lala, Anil K, Kwan-Feinberg, Rita O, Ross, Samuel W, Dressler, Jeremy A, Evans, Faye M, Wason, Shaun E L, Vogel, Keianna R, Wang, Joanna C, Sulciner, Megan L, Hirji, Sameer, Raoof, Mustafa, Wolff, Christopher J, kent, Ilan, Turan, Alparslan, Teixeira, Pedro G, Olson, Kristofor A, Patel, Neil D, Krishnamoorthy, Vijay, Moris, Dimitrios, Rice, Henry E, Gabr, Hesham, Satoskar, Savni R, Castater, Christine A, Jmaileh, Manal, Payne, Rachel E, Kwon, David S, Aarabi, Shahram, Escobar, Pedro F, Kronenfeld, Joshua P, Dalton, Michael K, Etchill, Eric W, Haut, Elliott R, Vervoort, Dominique, Dehal, Ahmed, McKenney, Mark, Elkbuli, Adel, Gosain, Ankush, Abdelsattar, Zaid M, Naunheim, Matthew R, Burks, Ciersten A, Zhou, Allen S, Heng, Marilyn, Abohashem, Shady, Lozano-Calderón, Santiago A, Reisenauer, Janani S, Mouawad, Nicolas J, Diehl, Thomas M, Eriksson, Evert A, Marwaha, Jayson S, Schroeppel, Thomas J, LaRocca, Christopher J, Chang, Grace H, Hassan, Romana, Nosanov, Lauren B, Rickard, Jennifer L, Avraham, Jacob B, Petrone, Patrizio, Sferra, Joseph J, Hadaya, Joseph, Mead, Brittany S, Hauptman, Jason S, Ahmad, Maleeha, Meola, Antonio, Chang, Steven D, Ko, Ara, Specht, Katherine E, Choudhry, Asad, Encalada, Ronald Zerna, Poggio, Juan L, Xing, Hang, Glass, Nina E, Hooker, Robert, Martins, Paulo N, Scott, Erin M, Bankhead, Brittany K, Giorgakis, Emmanouil, Nigh, Joe, Osborn, Tamara, Tay Lasso, Erika L, Beswick, Daniel M, Berndtson, Allison E, Kaups, Krista L, Chen, Lee-lynn, Farrell, Michael S, Boeck, Marissa A, Vaysburg, Dennis M, Kassam, Al-Faraaz, Turner, Kevin M, Dyas, Adam R, Coleman, Julia R, Folsom, Megan, Lam, Christopher M, Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust

Published
2022
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86. Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Author

Nadeu, Ferran, Royo, Romina, Massoni-Badosa, Ramon, Playa-Albinyana, Heribert, Garcia-Torre, Beatriz, Duran-Ferrer, Martí, Dawson, Kevin J., Kulis, Marta, Diaz-Navarro, Ander, Villamor, Neus, Melero, Juan L., Chapaprieta, Vicente, Dueso-Barroso, Ana, Delgado, Julio, Moia, Riccardo, Ruiz-Gil, Sara, Marchese, Domenica, Giró, Ariadna, Verdaguer-Dot, Núria, Romo, Mónica, Clot, Guillem, Rozman, Maria, Frigola, Gerard, Rivas-Delgado, Alfredo, Baumann, Tycho, Alcoceba, Miguel, González, Marcos, Climent, Fina, Abrisqueta, Pau, Castellví, Josep, Bosch, Francesc, Aymerich, Marta, Enjuanes, Anna, Ruiz-Gaspà, Sílvia, López-Guillermo, Armando, Jares, Pedro, Beà, Sílvia, Capella-Gutierrez, Salvador, Gelpí, Josep Ll., López-Bigas, Núria, Torrents, David, Campbell, Peter J., Gut, Ivo, Rossi, Davide, Gaidano, Gianluca, Puente, Xose S., Garcia-Roves, Pablo M., Colomer, Dolors, Heyn, Holger, Maura, Francesco, Martín-Subero, José I., and Campo, Elías

Published
2022
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93. New model to predict survival in advanced pancreatic ductal adenocarcinoma patients by measuring GGT and LDH levels and monocyte count.

Author

del Campo-Pedrosa, Rocío, Martín-Carnicero, Alfonso, González-Marcos, Ana, and Martínez, Alfredo

Abstract

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a poor survival outcome. Predicting patient survival allows physicians to tailor treatments to specific individuals. Thus, a simple and cost-effective prognosis model is sorely needed. Methods: This retrospective study assesses the prognostic value of blood biomarkers in advanced and metastatic PDAC patients (n=96) from Spain. Cut-off points for hematological parameters were calculated and correlated with overall survival (OS) using Kaplan-Meier, log-rank test, robust Cox proportional hazards and logistic regressions. Results: In univariate analysis, individuals with low levels of GGT, LDH, ALP, leukocyte-, neutrophil- and monocyte counts showed significantly longer survival than patients with higher levels. In multivariate analysis, lower levels of GGT (HR (95%CI), 2.734 (1.223-6.111); p=0.014), LDH (HR (95%CI), 1.876 (1.035-3.400); p=0.038) and monocyte count (HR (95%CI), 1.657 (1.095-2.506); p = 0.017) remained significantly beneficial. In consequence, we propose a prognostic model based on logistic regression (AUC=0.741) of these three biomarkers as a pioneer tool to estimate OS in PDAC. Conclusion: This study has demonstrated that the joint use of GGT (<92.00), LDH (<220.00) and monocyte count (<800) are independent positive prognostic factors in PDAC that can predict one-year survival in a novel prognostic logistic model. [ABSTRACT FROM AUTHOR]

Published
2025
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95. Uso de aplicaciones móviles en contextos educativos de infantil y primaria.

Author

Basilotta-Gómez-Pablos, Verónica, Casillas-Martín, Sonia, Cabezas-González, Marcos, and García-Valcárcel-Muñoz-Repiso, Ana

Abstract

Copyright of RED - Revista de Educación a Distancia is the property of Universidad de Murcia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2025
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96. Gaia Data Release 1. Testing the parallaxes with local Cepheids and RR Lyrae stars

Author

Gaia Collaboration, Clementini, G., Eyer, L., Ripepi, V., Marconi, M., Muraveva, T., Garofalo, A., Sarro, L. M., Palmer, M., Luri, X., Molinaro, R., Rimoldini, L., Szabados, L., Musella, I., Anderson, R. I., Prusti, T., de Bruijne, J. H. J., Brown, A. G. A., Vallenari, A., Babusiaux, C., Bailer-Jones, C. A. L., Bastian, U., Biermann, M., Evans, D. W., Jansen, F., Jordi, C., Klioner, S. A., Lammers, U., Lindegren, L., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H. I., Soubiran, C., Valette, V., van Leeuwen, F., Walton, N. A., Aerts, C., Arenou, F., Cropper, M., Drimmel, R., Høg, E., Katz, D., Lattanzi, M. G., O'Mullane, W., Grebel, E. K., Holland, A. D., Huc, C., Passot, X., Perryman, M., Bramante, L., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Hernández, J., Jean-Azntoine-Piccolo, A., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Ordóñez-Blanco, D., Panuzzo, P., Portell, J., Richards, P. J., Riello, M., Seabroke, G. M., Tanga, P., Thévenin, F., Torra, J., Els, S. G., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Lock, T., Mercier, E., Altmann, M., Andrae, R., Astraatmadja, T. L., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Busso, G., Carry, B., Cellino, A., Cowell, S., Creevey, O., Cuypers, J., Davidson, M., De Ridder, J., de Torres, A., Delchambre, L., Dell'Oro, A., Ducourant, C., Frémat, Y., García-Torres, M., Gosset, E., Halbwachs, J. -L., Hambly, N. C., Harrison, D. L., Hauser, M., Hestroffer, D., Hodgkin, S. T., Huckle, H. E., Hutton, A., Jasniewicz, G., Jordan, S., Kontizas, M., Korn, A. J., Lanzafame, A. C., Manteiga, M., Moitinho, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J. -M., Recio-Blanco, A., Robin, A. C., Siopis, C., Smith, M., Smith, K. W., Sozzetti, A., Thuillot, W., van Reeven, W., Viala, Y., Abbas, U., Aramburu, A. Abreu, Accart, S., Aguado, J. J., Allan, P. M., Allasia, W., Altavilla, G., Álvarez, M. A., Alves, J., Andrei, A. H., Varela, E. Anglada, Antiche, E., Antoja, T., Antón, S., Arcay, B., Bach, N., Baker, S. G., Balaguer-Núñez, L., Barache, C., Barata, C., Barbier, A., Barblan, F., Navascués, D. Barrado y, Barros, M., Barstow, M. A., Becciani, U., Bellazzini, M., García, A. Bello, Belokurov, V., Bendjoya, P., Berihuete, A., Bianchi, L., Bienaymé, O., Billebaud, F., Blagorodnova, N., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Borrachero, R., Bouquillon, S., Bourda, G., Bouy, H., Bragaglia, A., Breddels, M. A., Brouillet, N., Brüsemeister, T., Bucciarelli, B., Burgess, P., Burgon, R., Burlacu, A., Busonero, D., Buzzi, R., Caffau, E., Cambras, J., Campbell, H., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J. M., Castellani, M., Charlot, P., Charnas, J., Chiavassa, A., Clotet, M., Cocozza, G., Collins, R. S., Costigan, G., Crifo, F., Cross, N. J. G., Crosta, M., Crowley, C., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., De Cat, P., de Felice, F., de Laverny, P., De Luise, F., De March, R., de Souza, R., Debosscher, J., del Pozo, E., Delbo, M., Delgado, A., Delgado, H. E., Di Matteo, P., Diakite, S., Distefano, E., Dolding, C., Anjos, S. Dos, Drazinos, P., Durán, J., Dzigan, Y., Edvardsson, B., Enke, H., Evans, N. W., Bontemps, G. Eynard, Fabre, C., Fabrizio, M., Faigler, S., Falcão, A. J., Casas, M. Farràs, Federici, L., Fedorets, G., Fernández-Hernánde, J., Fernique, P., Fienga, A., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fouesneau, M., Fraile, E., Fraser, M., Fuchs, J., Gai, M., Galleti, S., Galluccio, L., Garabato, D., García-Sedano, F., Garralda, N., Gavras, P., Gerssen, J., Geyer, R., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., González-Marcos, A., González-Núñez, J., González-Vidal, J. J., Granvik, M., Guerrier, A., Guillout, P., Guiraud, J., Gúrpide, A., Gutiérrez-Sánchez, R., Guy, L. P., Haigron, R., Hatzidimitriou, D., Haywood, M., Heiter, U., Helmi, A., Hobbs, D., Hofmann, W., Holl, B., Holland, G., Hunt, J. A. S., Hypki, A., Icardi, V., Irwin, M., de Fombelle, G. Jevardat, Jofré, P., Jonker, P. G., Jorissen, A., Julbe, F., Karampelas, A., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, E., Koposov, S. E., Kordopatis, G., Koubsky, P., Krone-Martins, A., Kudryashova, M., Kull, I., Bachchan, R. K., Lacoste-Seris, F., Lanza, A. F., Lavigne, J. -B., Poncin-Lafitte, C. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lemaitre, V., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Löffler, W., López, M., Lorenz, D., MacDonald, I., Fernandes, T. Magalhães, Managau, S., Mann, R. G., Mantelet, G., Marchal, O., Marchant, J. M., Marinoni, S., Marrese, P. M., Marschalkó, G., Marshall, D. J., Martín-Fleitas, J. M., Martino, M., Mary, N., Matijevič, G., Mazeh, T., McMillan, P. J., Messina, S., Michalik, D., Millar, N. R., Miranda, B. M. H., Molina, D., Molinaro, M., Molnár, L., Moniez, M., Montegriffo, P., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A. F., Narbonne, J., Nelemans, G., Nicastro, L., Noval, L., Ordénovic, C., Ordieres-Meré, J., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Parsons, P., Pecoraro, M., Pedrosa, R., Pentikäinen, H., Pichon, B., Piersimoni, A. M., Pineau, F. -X., Plachy, E., Plum, G., Poujoulet, E., Prša, A., Pulone, L., Ragaini, S., Rago, S., Rambaux, N., Ramos-Lerate, M., Ranalli, P., Rauw, G., Read, A., Regibo, S., Reylé, C., Ribeiro, R. A., Riva, A., Rixon, G., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sellés, T. Sagristà, Sahlmann, J., Salgado, J., Salguero, E., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Segransan, D., Shih, I-C., Smareglia, R., Smart, R. L., Solano, E., Solitro, F., Sordo, R., Nieto, S. Soria, Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Stoev, H., Suess, F. F., Süveges, M., Surdej, J., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M. B., Teixeira, R., Terrett, D., Tingley, B., Trager, S. C., Turon, C., Ulla, A., Utrilla, E., Valentini, G., van Elteren, A., Van Hemelryck, E., van Leeuwen, M., Varadi, M., Vecchiato, A., Veljanoski, J., Via, T., Vicente, D., Vogt, S., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Weingrill, K., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Žerjal, M., Zucker, S., Zurbach, C., Zwitter, T., Alecu, A., Allen, M., Prieto, C. Allende, Amorim, A., Anglada-Escudé, G., Arsenijevic, V., Azaz, S., Balm, P., Beck, M., Bernstein, H. -H., Bigot, L., Bijaoui, A., Blasco, C., Bonfigli, M., Bono, G., Boudreault, S., Bressan, A., Brown, S., Brunet, P. -M., Bunclark, P., Buonanno, R., Butkevich, A. G., Carret, C., Carrion, C., Chemin, L., Chéreau, F., Corcione, L., Darmigny, E., de Boer, K. S., de Teodoro, P., de Zeeuw, P. T., Luche, C. Delle, Domingues, C. D., Dubath, P., Fodor, F., Frézouls, B., Fries, A., Fustes, D., Fyfe, D., Gallardo, E., Gallegos, J., Gardiol, D., Gebran, M., Gomboc, A., Gómez, A., Grux, E., Gueguen, A., Heyrovsky, A., Hoar, J., Iannicola, G., Parache, Y. Isasi, Janotto, A. -M., Joliet, E., Jonckheere, A., Keil, R., Kim, D. -W., Klagyivik, P., Klar, J., Knude, J., Kochukhov, O., Kolka, I., Kos, J., Kutka, A., Lainey, V., LeBouquin, D., Liu, C., Loreggia, D., Makarov, V. V., Marseille, M. G., Martayan, C., Martinez-Rubi, O., Massart, B., Meynadier, F., Mignot, S., Munari, U., Nguyen, A. -T., Nordlander, T., O'Flaherty, K. S., Ocvirk, P., Sanz, A. Olias, Ortiz, P., Osorio, J., Oszkiewicz, D., Ouzounis, A., Park, P., Pasquato, E., Peltzer, C., Peralta, J., Péturaud, F., Pieniluoma, T., Pigozzi, E., Poels, J., Prat, G., Prod'homme, T., Raison, F., Rebordao, J. M., Risquez, D., Rocca-Volmerange, B., Rosen, S., Ruiz-Fuertes, M. I., Russo, F., Sembay, S., Vizcaino, I. Serraller, Short, A., Siebert, A., Silva, H., Sinachopoulos, D., Slezak, E., Soffel, M., Sosnowska, D., Straižys, V., ter Linden, M., Terrell, D., Theil, S., Tiede, C., Troisi, L., Tsalmantza, P., Tur, D., Vaccari, M., Vachier, F., Valles, P., Van Hamme, W., Veltz, L., Virtanen, J., Wallut, J. -M., Wichmann, R., Wilkinson, M. I., Ziaeepour, H., and Zschocke, S.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

Parallaxes for 331 classical Cepheids, 31 Type II Cepheids and 364 RR Lyrae stars in common between Gaia and the Hipparcos and Tycho-2 catalogues are published in Gaia Data Release 1 (DR1) as part of the Tycho-Gaia Astrometric Solution (TGAS). In order to test these first parallax measurements of the primary standard candles of the cosmological distance ladder, that involve astrometry collected by Gaia during the initial 14 months of science operation, we compared them with literature estimates and derived new period-luminosity ($PL$), period-Wesenheit ($PW$) relations for classical and Type II Cepheids and infrared $PL$, $PL$-metallicity ($PLZ$) and optical luminosity-metallicity ($M_V$-[Fe/H]) relations for the RR Lyrae stars, with zero points based on TGAS. The new relations were computed using multi-band ($V,I,J,K_{\mathrm{s}},W_{1}$) photometry and spectroscopic metal abundances available in the literature, and applying three alternative approaches: (i) by linear least squares fitting the absolute magnitudes inferred from direct transformation of the TGAS parallaxes, (ii) by adopting astrometric-based luminosities, and (iii) using a Bayesian fitting approach. TGAS parallaxes bring a significant added value to the previous Hipparcos estimates. The relations presented in this paper represent first Gaia-calibrated relations and form a "work-in-progress" milestone report in the wait for Gaia-only parallaxes of which a first solution will become available with Gaia's Data Release 2 (DR2) in 2018., Comment: 29 pages, 25 figures. Accepted for publication by A&A

Published
2017
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97. Gaia Data Release 1. Open cluster astrometry: performance, limitations, and future prospects

Author

Gaia Collaboration, van Leeuwen, F., Vallenari, A., Jordi, C., Lindegren, L., Bastian, U., Prusti, T., de Bruijne, J. H. J., Brown, A. G. A., Babusiaux, C., Bailer-Jones, C. A. L., Biermann, M., Evans, D. W., Eyer, L., Jansen, F., Klioner, S. A., Lammers, U., Luri, X., Mignard, F., Panem, C., Pourbaix, D., Randich, S., Sartoretti, P., Siddiqui, H. I., Soubiran, C., Valette, V., Walton, N. A., Aerts, C., Arenou, F., Cropper, M., Drimmel, R., Høg, E., Katz, D., Lattanzi, M. G., O'Mullane, W., Grebel, E. K., Holland, A. D., Huc, C., Passot, X., Perryman, M., Bramante, L., Cacciari, C., Castañeda, J., Chaoul, L., Cheek, N., De Angeli, F., Fabricius, C., Guerra, R., Hernández, J., Jean-Antoine-Piccolo, A., Masana, E., Messineo, R., Mowlavi, N., Nienartowicz, K., Ordóñez-Blanco, D., Panuzzo, P., Portell, J., Richards, P. J., Riello, M., Seabroke, G. M., Tanga, P., Thévenin, F., Torra, J., Els, S. G., Gracia-Abril, G., Comoretto, G., Garcia-Reinaldos, M., Lock, T., Mercier, E., Altmann, M., Andrae, R., Astraatmadja, T. L., Bellas-Velidis, I., Benson, K., Berthier, J., Blomme, R., Busso, G., Carry, B., Cellino, A., Clementini, G., Cowell, S., Creevey, O., Cuypers, J., Davidson, M., De Ridder, J., de Torres, A., Delchambre, L., Dell'Oro, A., Ducourant, C., Frémat, Y., García-Torres, M., Gosset, E., Halbwachs, J. -L., Hambly, N. C., Harrison, D. L., Hauser, M., Hestroffer, D., Hodgkin, S. T., Huckle, H. E., Hutton, A., Jasniewicz, G., Jordan, S., Kontizas, M., Korn, A. J., Lanzafame, A. C., Manteiga, M., Moitinho, A., Muinonen, K., Osinde, J., Pancino, E., Pauwels, T., Petit, J. -M., Recio-Blanco, A., Robin, A. C., Sarro, L. M., Siopis, C., Smith, M., Smith, K. W., Sozzetti, A., Thuillot, W., van Reeven, W., Viala, Y., Abbas, U., Aramburu, A. Abreu, Accart, S., Aguado, J. J., Allan, P. M., Allasia, W., Altavilla, G., Álvarez, M. A., Alves, J., Anderson, R. I., Andrei, A. H., Varela, E. Anglada, Antiche, E., Antoja, T., Antón, S., Arcay, B., Bach, N., Baker, S. G., Balaguer-Núñez, L., Barache, C., Barata, C., Barbier, A., Barblan, F., Navascués, D. Barrado y, Barros, M., Barstow, M. A., Becciani, U., Bellazzini, M., García, A. Bello, Belokurov, V., Bendjoya, P., Berihuete, A., Bianchi, L., Bienaymé, O., Billebaud, F., Blagorodnova, N., Blanco-Cuaresma, S., Boch, T., Bombrun, A., Borrachero, R., Bouquillon, S., Bourda, G., Bouy, H., Bragaglia, A., Breddels, M. A., Brouillet, N., Brüsemeister, T., Bucciarelli, B., Burgess, P., Burgon, R., Burlacu, A., Busonero, D., Buzzi, R., Caffau, E., Cambras, J., Campbell, H., Cancelliere, R., Cantat-Gaudin, T., Carlucci, T., Carrasco, J. M., Castellani, M., Charlot, P., Charnas, J., Chiavassa, A., Clotet, M., Cocozza, G., Collins, R. S., Costigan, G., Crifo, F., Cross, N. J. G., Crosta, M., Crowley, C., Dafonte, C., Damerdji, Y., Dapergolas, A., David, P., David, M., De Cat, P., de Felice, F., de Laverny, P., De Luise, F., De March, R., de Martino, D., de Souza, R., Debosscher, J., del Pozo, E., Delbo, M., Delgado, A., Delgado, H. E., Di Matteo, P., Diakite, S., Distefano, E., Dolding, C., Anjos, S. Dos, Drazinos, P., Durán, J., Dzigan, Y., Edvardsson, B., Enke, H., Evans, N. W., Bontemps, G. Eynard, Fabre, C., Fabrizio, M., Faigler, S., Falcão, A. J., Casas, M. Farràs, Federici, L., Fedorets, G., Fernández-Hernández, J., Fernique, P., Fienga, A., Figueras, F., Filippi, F., Findeisen, K., Fonti, A., Fouesneau, M., Fraile, E., Fraser, M., Fuchs, J., Gai, M., Galleti, S., Galluccio, L., Garabato, D., García-Sedano, F., Garofalo, A., Garralda, N., Gavras, P., Gerssen, J., Geyer, R., Gilmore, G., Girona, S., Giuffrida, G., Gomes, M., González-Marcos, A., González-Núñez, J., González-Vidal, J. J., Granvik, M., Guerrier, A., Guillout, P., Guiraud, J., Gúrpide, A., Gutiérrez-Sánchez, R., Guy, L. P., Haigron, R., Hatzidimitriou, D., Haywood, M., Heiter, U., Helmi, A., Hobbs, D., Hofmann, W., Holl, B., Holland, G., Hunt, J. A. S., Hypki, A., Icardi, V., Irwin, M., de Fombelle, G. Jevardat, Jofré, P., Jonker, P. G., Jorissen, A., Julbe, F., Karampelas, A., Kochoska, A., Kohley, R., Kolenberg, K., Kontizas, E., Koposov, S. E., Kordopatis, G., Koubsky, P., Krone-Martins, A., Kudryashova, M., Kull, I., Bachchan, R. K., Lacoste-Seris, F., Lanza, A. F., Lavigne, J. -B., Poncin-Lafitte, C. Le, Lebreton, Y., Lebzelter, T., Leccia, S., Leclerc, N., Lecoeur-Taibi, I., Lemaitre, V., Lenhardt, H., Leroux, F., Liao, S., Licata, E., Lindstrøm, H. E. P., Lister, T. A., Livanou, E., Lobel, A., Löffer, W., López, M., Lorenz, D., MacDonald, I., Fernandes, T. Magalhães, Managau, S., Mann, R. G., Mantelet, G., Marchal, O., Marchant, J. M., Marconi, M., Marinoni, S., Marrese, P. M., Marschalkó, G., Marshall, D. J., Martín-Fleitas, J. M., Martino, M., Mary, N., Matijevič, G., Mazeh, T., McMillan, P. J., Messina, S., Michalik, D., Millar, N. R., Miranda, B. M. H., Molina, D., Molinaro, R., Molinaro, M., Molnár, L., Moniez, M., Montegrio, P., Mor, R., Mora, A., Morbidelli, R., Morel, T., Morgenthaler, S., Morris, D., Mulone, A. F., Muraveva, T., Musella, I., Narbonne, J., Nelemans, G., Nicastro, L., Noval, L., Ordénovic, C., Ordieres-Meré, J., Osborne, P., Pagani, C., Pagano, I., Pailler, F., Palacin, H., Palaversa, L., Parsons, P., Pecoraro, M., Pedrosa, R., Pentikäinen, H., Pichon, B., Piersimoni, A. M., Pineau, F. -X., Plachy, E., Plum, G., Poujoulet, E., Prša, A., Pulone, L., Ragaini, S., Rago, S., Rambaux, N., Ramos-Lerate, M., Ranalli, P., Rauw, G., Read, A., Regibo, S., Reylé, C., Ribeiro, R. A., Rimoldini, L., Ripepi, V., Riva, A., Rixon, G., Roelens, M., Romero-Gómez, M., Rowell, N., Royer, F., Ruiz-Dern, L., Sadowski, G., Sellés, T. Sagristà, Sahlmann, J., Salgado, J., Salguero, E., Sarasso, M., Savietto, H., Schultheis, M., Sciacca, E., Segol, M., Segovia, J. C., Segransan, D., Shih, I-C., Smareglia, R., Smart, R. L., Solano, E., Solitro, F., Sordo, R., Nieto, S. Soria, Souchay, J., Spagna, A., Spoto, F., Stampa, U., Steele, I. A., Steidelmüller, H., Stephenson, C. A., Stoev, H., Suess, F. F., Süveges, M., Surdej, J., Szabados, L., Szegedi-Elek, E., Tapiador, D., Taris, F., Tauran, G., Taylor, M. B., Teixeira, R., Terrett, D., Tingley, B., Trager, S. C., Turon, C., Ulla, A., Utrilla, E., Valentini, G., van Elteren, A., Van Hemelryck, E., van Leeuwen, M., Varadi, M., Vecchiato, A., Veljanoski, J., Via, T., Vicente, D., Vogt, S., Voss, H., Votruba, V., Voutsinas, S., Walmsley, G., Weiler, M., Weingril, K., Wevers, T., Wyrzykowski, Ł., Yoldas, A., Žerjal, M., Zucker, S., Zurbach, C., Zwitter, T., Alecu, A., Allen, M., Prieto, C. Allende, Amorim, A., Anglada-Escudé, G., Arsenijevic, V., Azaz, S., Balm, P., Beck, M., Bernsteiny, H. -H., Bigot, L., Bijaoui, A., Blasco, C., Bonfigli, M., Bono, G., Boudreault, S., Bressan, A., Brown, S., Brunet, P. -M., Bunclarky, P., Buonanno, R., Butkevich, A. G., Carret, C., Carrion, C., Chemin, L., Chéreau, F., Corcione, L., Darmigny, E., de Boer, K. S., de Teodoro, P., de Zeeuw, P. T., Luche, C. Delle, Domingues, C. D., Dubath, P., Fodor, F., Frézouls, B., Fries, A., Fustes, D., Fyfe, D., Gallardo, E., Gallegos, J., Gardio, D., Gebran, M., Gomboc, A., Gómez, A., Grux, E., Gueguen, A., Heyrovsky, A., Hoar, J., Iannicola, G., Parache, Y. Isasi, Janotto, A. -M., Joliet, E., Jonckheere, A., Keil, R., Kim, D. -W., Klagyivik, P., Klar, J., Knude, J., Kochukhov, O., Kolka, I., Kos, J., Kutka, A., Lainey, V., LeBouquin, D., Liu, C., Loreggia, D., Makarov, V. V., Marseille, M. G., Martayan, C., Martinez-Rubi, O., Massart, B., Meynadier, F., Mignot, S., Munari, U., Nguyen, A. -T., Nordlander, T., O'Flaherty, K. S., Ocvirk, P., Sanz, A. Olias, Ortiz, P., Osorio, J., Oszkiewicz, D., Ouzounis, A., Palmer, M., Park, P., Pasquato, E., Peltzer, C., Peralta, J., Péturaud, F., Pieniluoma, T., Pigozzi, E., Poelsy, J., Prat, G., Prod'homme, T., Raison, F., Rebordao, J. M., Risquez, D., Rocca-Volmerange, B., Rosen, S., Ruiz-Fuertes, M. I., Russo, F., Sembay, S., Vizcaino, I. Serraller, Short, A., Siebert, A., Silva, H., Sinachopoulos, D., Slezak, E., Soffel, M., Sosnowska, D., Straižys, V., ter Linden, M., Terrell, D., Theil, S., Tiede, C., Troisi, L., Tsalmantza, P., Tur, D., Vaccari, M., Vachier, F., Valles, P., Van Hamme, W., Veltz, L., Virtanen, J., Wallut, J. -M., Wichmann, R., Wilkinson, M. I., Ziaeepour, H., and Zschocke, S.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Context. The first Gaia Data Release contains the Tycho-Gaia Astrometric Solution (TGAS). This is a subset of about 2 million stars for which, besides the position and photometry, the proper motion and parallax are calculated using Hipparcos and Tycho-2 positions in 1991.25 as prior information. Aims. We investigate the scientific potential and limitations of the TGAS component by means of the astrometric data for open clusters. Methods. Mean cluster parallax and proper motion values are derived taking into account the error correlations within the astrometric solutions for individual stars, an estimate of the internal velocity dispersion in the cluster, and, where relevant, the effects of the depth of the cluster along the line of sight. Internal consistency of the TGAS data is assessed. Results. Values given for standard uncertainties are still inaccurate and may lead to unrealistic unit-weight standard deviations of least squares solutions for cluster parameters. Reconstructed mean cluster parallax and proper motion values are generally in very good agreement with earlier Hipparcos-based determination, although the Gaia mean parallax for the Pleiades is a significant exception. We have no current explanation for that discrepancy. Most clusters are observed to extend to nearly 15 pc from the cluster centre, and it will be up to future Gaia releases to establish whether those potential cluster-member stars are still dynamically bound to the clusters. Conclusions. The Gaia DR1 provides the means to examine open clusters far beyond their more easily visible cores, and can provide membership assessments based on proper motions and parallaxes. A combined HR diagram shows the same features as observed before using the Hipparcos data, with clearly increased luminosities for older A and F dwarfs., Comment: Accepted for publication by A&A. 21 pages main text plus 46 pages appendices. 34 figures main text, 38 figures appendices. 8 table in main text, 19 tables in appendices

Published
2017
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98. Observaciones sobre los tricópteros (Insecta, Trichoptera) del suroeste de la península ibérica: Extremadura y Córdoba.

Author

MARTÍNEZ, JESÚS, MARTÍN, LUÍS, and GONZÁLEZ, MARCOS A.

Abstract

Copyright of Boletín de la Asociación Española de Entomología is the property of Asociacion Espanola de Entomologia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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99. Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study.

Author

Alvarado, Ysaías J., González-Paz, Lenin, Paz, José L., Loroño-González, Marcos A., Santiago Contreras, Julio, Lossada, Carla, Vivas, Alejandro, Marrero-Ponce, Yovani, Martinez-Rios, Felix, Rodriguez-Lugo, Patricia, Balladores, Yanpiero, and Vera-Villalobos, Joan

Subjects
LEWY body dementia, ALZHEIMER'S disease, ACTION potentials, NEURODEGENERATION, THERAPEUTICS, ACETYLCHOLINESTERASE
Abstract

Simple Summary: Acetylcholinesterase (AChE) is a key enzyme responsible for terminating nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has gained attention as a therapeutic strategy for neurological disorders including Lewy body dementia and Alzheimer's disease. This study investigated the effects of natural compounds on the intrinsic deformability of human AChE through computational biophysical analysis, utilizing methods such as classical dynamics, elastic networks, statistical potentials, energy frustration, and volumetric cavity analyses. The findings indicate that cyanidin significantly alters the flexibility and rigidity of AChE, particularly affecting the distribution and volume of its internal cavities, in contrast to model inhibitors like TZ2PA6. This distinct biophysical-molecular mechanism demonstrated by cyanidin highlights its potential as a target for future research and the development of new treatments for neurodegenerative diseases. The enzyme acetylcholinesterase (AChE) plays a crucial role in the termination of nerve impulses by hydrolyzing the neurotransmitter acetylcholine (ACh). The inhibition of AChE has emerged as a promising therapeutic approach for the management of neurological disorders such as Lewy body dementia and Alzheimer's disease. The potential of various compounds as AChE inhibitors was investigated. In this study, we evaluated the impact of natural compounds of interest on the intrinsic deformability of human AChE using computational biophysical analysis. Our approach incorporates classical dynamics, elastic networks (ENM and NMA), statistical potentials (CUPSAT and SWOTein), energy frustration (Frustratometer), and volumetric cavity analyses (MOLE and PockDrug). The results revealed that cyanidin induced significant changes in the flexibility and rigidity of AChE, especially in the distribution and volume of internal cavities, compared to model inhibitors such as TZ2PA6, and through a distinct biophysical-molecular mechanism from the other inhibitors considered. These findings suggest that cyanidin could offer potential mechanistic pathways for future research and applications in the development of new treatments for neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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100. Phosphine Catalyzed Michael-Type Additions: The Synthesis of Glutamic Acid Derivatives from Arylidene-α-amino Esters

Author

Lesly V. Rodríguez-Flórez, María González-Marcos, Eduardo García-Mingüens, María de Gracia Retamosa, Misa Kawase, Elisabet Selva, and José M. Sansano

Subjects
organocatalysis, phosphines, imino esters, Michael addition, glutamates, pyroglutamates, Organic chemistry, QD241-441
Abstract

The reaction of arylidene-α-amino esters with electrophilic alkenes to yield Michael-type addition compounds is optimized using several phosphines as organocatalysts. The transformation is very complicated due to the generation of several final compounds, including those derived from the 1,3-dipolar cycloadditions. For this reason, the selection of the reaction conditions is a very complex task and the slow addition of the acrylic system is very important to complete the process. The study of the variation in the structural components of the starting imino ester is performed as well as the expansion of other electron-poor alkenes. The crude products have a purity higher than 90% in most cases without any purification. A plausible mechanism is detailed based on the bibliography and the experimental results. The synthesis of pyroglutamate entities, after the reduction of the imino group and cyclization, is performed in high yields. In addition, the hydrolysis of the imino group, under acidic media, represents a direct access to glutamate surrogates.

Published
2024
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