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466 results on '"Glasspool, Rosalind"'

51. Supplementary methods and legends from The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma

Author

Cooke, Susanna L., primary, Ennis, Darren, primary, Evers, Lisa, primary, Dowson, Suzanne, primary, Chan, Mei Yen, primary, Paul, James, primary, Hirschowitz, Lynn, primary, Glasspool, Rosalind M., primary, Singh, Naveena, primary, Bell, Sarah, primary, Day, Elizabeth, primary, Kochman, Agata, primary, Wilkinson, Nafisa, primary, Beer, Philip, primary, Martin, Sancha, primary, Millan, David, primary, Biankin, Andrew V., primary, and McNeish, Iain A., primary

Published
2023
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52. Data from Genome-wide Analysis Identifies Novel Loci Associated with Ovarian Cancer Outcomes: Findings from the Ovarian Cancer Association Consortium

Author

Johnatty, Sharon E., primary, Tyrer, Jonathan P., primary, Kar, Siddhartha, primary, Beesley, Jonathan, primary, Lu, Yi, primary, Gao, Bo, primary, Fasching, Peter A., primary, Hein, Alexander, primary, Ekici, Arif B., primary, Beckmann, Matthias W., primary, Lambrechts, Diether, primary, Van Nieuwenhuysen, Els, primary, Vergote, Ignace, primary, Lambrechts, Sandrina, primary, Rossing, Mary Anne, primary, Doherty, Jennifer A., primary, Chang-Claude, Jenny, primary, Modugno, Francesmary, primary, Ness, Roberta B., primary, Moysich, Kirsten B., primary, Levine, Douglas A., primary, Kiemeney, Lambertus A., primary, Massuger, Leon F.A.G., primary, Gronwald, Jacek, primary, Lubiński, Jan, primary, Jakubowska, Anna, primary, Cybulski, Cezary, primary, Brinton, Louise, primary, Lissowska, Jolanta, primary, Wentzensen, Nicolas, primary, Song, Honglin, primary, Rhenius, Valerie, primary, Campbell, Ian, primary, Eccles, Diana, primary, Sieh, Weiva, primary, Whittemore, Alice S., primary, McGuire, Valerie, primary, Rothstein, Joseph H., primary, Sutphen, Rebecca, primary, Anton-Culver, Hoda, primary, Ziogas, Argyrios, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Ramus, Susan J., primary, Pearce, Celeste L., primary, Pike, Malcolm C., primary, Stram, Daniel O., primary, Wu, Anna H., primary, Kupryjanczyk, Jolanta, primary, Dansonka-Mieszkowska, Agnieszka, primary, Rzepecka, Iwona K., primary, Spiewankiewicz, Beata, primary, Goodman, Marc T., primary, Wilkens, Lynne R., primary, Carney, Michael E., primary, Thompson, Pamela J., primary, Heitz, Florian, primary, du Bois, Andreas, primary, Schwaab, Ira, primary, Harter, Philipp, primary, Pisterer, Jacobus, primary, Hillemanns, Peter, primary, Karlan, Beth Y., primary, Walsh, Christine, primary, Lester, Jenny, primary, Orsulic, Sandra, primary, Winham, Stacey J., primary, Earp, Madalene, primary, Larson, Melissa C., primary, Fogarty, Zachary C., primary, Høgdall, Estrid, primary, Jensen, Allan, primary, Kjaer, Susanne Kruger, primary, Fridley, Brooke L., primary, Cunningham, Julie M., primary, Vierkant, Robert A., primary, Schildkraut, Joellen M., primary, Iversen, Edwin S., primary, Terry, Kathryn L., primary, Cramer, Daniel W., primary, Bandera, Elisa V., primary, Orlow, Irene, primary, Pejovic, Tanja, primary, Bean, Yukie, primary, Høgdall, Claus, primary, Lundvall, Lene, primary, McNeish, Ian, primary, Paul, James, primary, Carty, Karen, primary, Siddiqui, Nadeem, primary, Glasspool, Rosalind, primary, Sellers, Thomas, primary, Kennedy, Catherine, primary, Chiew, Yoke-Eng, primary, Berchuck, Andrew, primary, MacGregor, Stuart, primary, Pharoah, Paul D.P., primary, Goode, Ellen L., primary, deFazio, Anna, primary, Webb, Penelope M., primary, and Chenevix-Trench, Georgia, primary

Published
2023
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53. CA-125 Early Dynamics to Predict Overall Survival in Women with Newly Diagnosed Advanced Ovarian Cancer Based on Meta-Analysis Data

Author

Karamouza, Eleni, primary, Glasspool, Rosalind M., additional, Kelly, Caroline, additional, Lewsley, Liz-Anne, additional, Carty, Karen, additional, Kristensen, Gunnar B., additional, Ethier, Josee-Lyne, additional, Kagimura, Tatsuo, additional, Yanaihara, Nozomu, additional, Cecere, Sabrina Chiara, additional, You, Benoit, additional, Boere, Ingrid A., additional, Pujade-Lauraine, Eric, additional, Ray-Coquard, Isabelle, additional, Proust-Lima, Cécile, additional, and Paoletti, Xavier, additional

Published
2023
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54. CA-125 Early Dynamics to Predict Overall Survival in Women with Newly Diagnosed Advanced Ovarian Cancer Based on Meta-Analysis Data

Author

Karamouza, Eleni, Glasspool, Rosalind M., Kelly, Caroline, Lewsley, Liz Anne, Carty, Karen, Kristensen, Gunnar B., Ethier, Josee Lyne, Kagimura, Tatsuo, Yanaihara, Nozomu, Cecere, Sabrina Chiara, You, Benoit, Boere, Ingrid A., Pujade-Lauraine, Eric, Ray-Coquard, Isabelle, Proust-Lima, Cécile, Paoletti, Xavier, Karamouza, Eleni, Glasspool, Rosalind M., Kelly, Caroline, Lewsley, Liz Anne, Carty, Karen, Kristensen, Gunnar B., Ethier, Josee Lyne, Kagimura, Tatsuo, Yanaihara, Nozomu, Cecere, Sabrina Chiara, You, Benoit, Boere, Ingrid A., Pujade-Lauraine, Eric, Ray-Coquard, Isabelle, Proust-Lima, Cécile, and Paoletti, Xavier

Abstract

(1) Background: Cancer antigen 125 (CA-125) is a protein produced by ovarian cancer cells that is used for patients’ monitoring. However, the best ways to analyze its decline and prognostic role are poorly quantified. (2) Methods: We leveraged individual patient data from the Gynecologic Cancer Intergroup (GCIG) meta-analysis (N = 5573) to compare different approaches summarizing the early trajectory of CA-125 before the prediction time (called the landmark time) at 3 or 6 months after treatment initiation in order to predict overall survival. These summaries included observed and estimated measures obtained by a linear mixed model (LMM). Their performances were evaluated by 10-fold cross-validation with the Brier score and the area under the ROC (AUC). (3) Results: The estimated value and the last observed value at 3 months were the best measures used to predict overall survival, with an AUC of 0.75 CI 95% [0.70; 0.80] at 24 and 36 months and 0.74 [0.69; 0.80] and 0.75 [0.69; 0.80] at 48 months, respectively, considering that CA-125 over 6 months did not improve the AUC, with 0.74 [0.68; 0.78] at 24 months and 0.71 [0.65; 0.76] at 36 and 48 months. (4) Conclusions: A 3-month surveillance provided reliable individual information on overall survival until 48 months for patients receiving first-line chemotherapy.

Published
2023

55. No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer

Author

Hollestelle, Antoinette, van der Baan, Frederieke H., Berchuck, Andrew, Johnatty, Sharon E., Aben, Katja K., Agnarsson, Bjarni A., Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia N., Antoniou, Antonis C., Apicella, Carmel, Arndt, Volker, Arnold, Norbert, Arun, Banu K., Arver, Brita, Ashworth, Alan, Baglietto, Laura, Balleine, Rosemary, Bandera, Elisa V., Barrowdale, Daniel, Bean, Yukie T., Beckmann, Lars, Beckmann, Matthias W., Benitez, Javier, Berger, Andreas, Berger, Raanan, Beuselinck, Benoit, Bisogna, Maria, Bjorge, Line, Blomqvist, Carl, Bogdanova, Natalia V., Bojesen, Anders, Bojesen, Stig E., Bolla, Manjeet K., Bonanni, Bernardo, Brand, Judith S., Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Brüning, Thomas, Budzilowska, Agnieszka, Bunker, Clareann H., Burwinkel, Barbara, Butzow, Ralf, Buys, Saundra S., Caligo, Maria A., Campbell, Ian, Carter, Jonathan, Chang-Claude, Jenny, Chanock, Stephen J., Claes, Kathleen B.M., Collée, J. Margriet, Cook, Linda S., Couch, Fergus J., Cox, Angela, Cramer, Daniel, Cross, Simon S., Cunningham, Julie M., Cybulski, Cezary, Czene, Kamila, Damiola, Francesca, Dansonka-Mieszkowska, Agnieszka, Darabi, Hatef, de la Hoya, Miguel, deFazio, Anna, Dennis, Joseph, Devilee, Peter, Dicks, Ed M., Diez, Orland, Doherty, Jennifer A., Domchek, Susan M., Dorfling, Cecilia M., Dörk, Thilo, Silva, Isabel Dos Santos, du Bois, Andreas, Dumont, Martine, Dunning, Alison M., Duran, Mercedes, Easton, Douglas F., Eccles, Diana, Edwards, Robert P., Ehrencrona, Hans, Ejlertsen, Bent, Ekici, Arif B., Ellis, Steve D., Engel, Christoph, Eriksson, Mikael, Fasching, Peter A., Feliubadalo, Lidia, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Fontaine, Annette, Fortuzzi, Stefano, Fostira, Florentia, Fridley, Brooke L., Friebel, Tara, Friedman, Eitan, Friel, Grace, Frost, Debra, Garber, Judy, García-Closas, Montserrat, Gayther, Simon A., Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K., Goodman, Marc T., Gore, Martin, Greene, Mark H., Grip, Mervi, Gronwald, Jacek, Gschwantler Kaulich, Daphne, Guénel, Pascal, Guzman, Starr R., Haeberle, Lothar, Haiman, Christopher A., Hall, Per, Halverson, Sandra L., Hamann, Ute, Hansen, Thomas V.O., Harter, Philipp, Hartikainen, Jaana M., Healey, Sue, Hein, Alexander, Heitz, Florian, Henderson, Brian E., Herzog, Josef, T Hildebrandt, Michelle A., Høgdall, Claus K., Høgdall, Estrid, Hogervorst, Frans B.L., Hopper, John L., Humphreys, Keith, Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Jakubowska, Anna, Janavicius, Ramunas, Jaworska, Katarzyna, Jensen, Allan, Jensen, Uffe Birk, Johnson, Nichola, Jukkola-Vuorinen, Arja, Kabisch, Maria, Karlan, Beth Y., Kataja, Vesa, Kauff, Noah, Kelemen, Linda E., Kerin, Michael J., Kiemeney, Lambertus A., Kjaer, Susanne K., Knight, Julia A., Knol-Bout, Jacoba P., Konstantopoulou, Irene, Kosma, Veli-Matti, Krakstad, Camilla, Kristensen, Vessela, Kuchenbaecker, Karoline B., Kupryjanczyk, Jolanta, Laitman, Yael, Lambrechts, Diether, Lambrechts, Sandrina, Larson, Melissa C., Lasa, Adriana, Laurent-Puig, Pierre, Lazaro, Conxi, Le, Nhu D., Le Marchand, Loic, Leminen, Arto, Lester, Jenny, Levine, Douglas A., Li, Jingmei, Liang, Dong, Lindblom, Annika, Lindor, Noralane, Lissowska, Jolanta, Long, Jirong, Lu, Karen H., Lubinski, Jan, Lundvall, Lene, Lurie, Galina, Mai, Phuong L., Mannermaa, Arto, Margolin, Sara, Mariette, Frederique, Marme, Frederik, Martens, John W.M., Massuger, Leon F.A.G., Maugard, Christine, Mazoyer, Sylvie, McGuffog, Lesley, McGuire, Valerie, McLean, Catriona, McNeish, Iain, Meindl, Alfons, Menegaux, Florence, Menéndez, Primitiva, Menkiszak, Janusz, Menon, Usha, Mensenkamp, Arjen R., Miller, Nicola, Milne, Roger L., Modugno, Francesmary, Montagna, Marco, Moysich, Kirsten B., Müller, Heiko, Mulligan, Anna Marie, Muranen, Taru A., Narod, Steven A., Nathanson, Katherine L., Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Neven, Patrick, Nielsen, Finn C., Nielsen, Sune F., Nordestgaard, Børge G., Nussbaum, Robert L., Odunsi, Kunle, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I., Olson, Janet E., Olson, Sara H., Oosterwijk, Jan C., Orlow, Irene, Orr, Nick, Orsulic, Sandra, Osorio, Ana, Ottini, Laura, Paul, James, Pearce, Celeste L., Pedersen, Inge Sokilde, Peissel, Bernard, Pejovic, Tanja, Pelttari, Liisa M., Perkins, Jo, Permuth-Wey, Jenny, Peterlongo, Paolo, Peto, Julian, Phelan, Catherine M., Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C., Platte, Radka, Plisiecka-Halasa, Joanna, Poole, Elizabeth M., Poppe, Bruce, Pylkäs, Katri, Radice, Paolo, Ramus, Susan J., Rebbeck, Timothy R., Reed, Malcolm W.R., Rennert, Gad, Risch, Harvey A., Robson, Mark, Rodriguez, Gustavo C., Romero, Atocha, Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo, Salani, Ritu, Salvesen, Helga B., Sawyer, Elinor J., Schildkraut, Joellen M., Schmidt, Marjanka K., Schmutzler, Rita K., Schneeweiss, Andreas, Schoemaker, Minouk J., Schrauder, Michael G., Schumacher, Fredrick, Schwaab, Ira, Scuvera, Giulietta, Sellers, Thomas A., Severi, Gianluca, Seynaeve, Caroline M., Shah, Mitul, Shrubsole, Martha, Siddiqui, Nadeem, Sieh, Weiva, Simard, Jacques, Singer, Christian F., Sinilnikova, Olga M., Smeets, Dominiek, Sohn, Christof, Soller, Maria, Song, Honglin, Soucy, Penny, Southey, Melissa C., Stegmaier, Christa, Stoppa-Lyonnet, Dominique, Sucheston, Lara, Swerdlow, Anthony, Tangen, Ingvild L., Tea, Muy-Kheng, Teixeira, Manuel R., Terry, Kathryn L., Terry, Mary Beth, Thomassen, Mads, Thompson, Pamela J., Tihomirova, Laima, Tischkowitz, Marc, Toland, Amanda Ewart, Tollenaar, Rob A.E.M., Tomlinson, Ian, Torres, Diana, Truong, Thérèse, Tsimiklis, Helen, Tung, Nadine, Tworoger, Shelley S., Tyrer, Jonathan P., Vachon, Celine M., Van 't Veer, Laura J., van Altena, Anne M., Van Asperen, C.J., van den Berg, David, van den Ouweland, Ans M.W., van Doorn, Helena C., Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J., Vergote, Ignace, Verhoef, Senno, Vierkant, Robert A., Vijai, Joseph, Vitonis, Allison F., von Wachenfeldt, Anna, Walsh, Christine, Wang, Qin, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Weischer, Maren, Weitzel, Jeffrey N., Weltens, Caroline, Wentzensen, Nicolas, Whittemore, Alice S., Wilkens, Lynne R., Winqvist, Robert, Wu, Anna H., Wu, Xifeng, Yang, Hannah P., Zaffaroni, Daniela, Pilar Zamora, M., Zheng, Wei, Ziogas, Argyrios, Chenevix-Trench, Georgia, Pharoah, Paul D.P., Rookus, Matti A., Hooning, Maartje J., and Goode, Ellen L.

Published
2016
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56. British Gynaecological Cancer Society Recommendations for Evidence Based, Population Data Derived Quality Performance Indicators for Ovarian Cancer

Author

Sundar, Sudha, primary, Nordin, Andy, additional, Morrison, Jo, additional, Wood, Nick, additional, Ghaem-Maghami, Sadaf, additional, Nieto, Jo, additional, Phillips, Andrew, additional, Butler, John, additional, Burton, Kevin, additional, Gornall, Rob, additional, Dobbs, Stephen, additional, Glasspool, Rosalind, additional, Peevor, Richard, additional, Ledermann, Jonathan, additional, McNeish, Iain, additional, Ratnavelu, Nithya, additional, Duncan, Tim, additional, Frost, Jonathan, additional, Lim, Kenneth, additional, Michael, Agnieszka, additional, Brockbank, Elly, additional, Gajjar, Ketankumar, additional, Taylor, Alexandra, additional, Bowen, Rebecca, additional, Andreou, Adrian, additional, Ganesan, Raji, additional, Nicum, Shibani, additional, Edmondson, Richard, additional, Clayton, Richard, additional, Balega, Janos, additional, Rolland, Phil, additional, Maxwell, Hilary, additional, and Fotopoulou, Christina, additional

Published
2023
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57. Evaluating the ovarian cancer gonadotropin hypothesis: A candidate gene study

Author

Lee, Alice W., Tyrer, Jonathan P., Doherty, Jennifer A., Stram, Douglas A., Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Plisiecka-Halasa, Joanna, Spiewankiewicz, Beata, Myers, Emily J., Chenevix-Trench, Georgia, Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hein, Alexander, Vergote, Ignace, Van Nieuwenhuysen, Els, Lambrechts, Diether, Wicklund, Kristine G., Eilber, Ursula, Wang-Gohrke, Shan, Chang-Claude, Jenny, Rudolph, Anja, Sucheston-Campbell, Lara, Odunsi, Kunle, Moysich, Kirsten B., Shvetsov, Yurii B., Thompson, Pamela J., Goodman, Marc T., Wilkens, Lynne R., Dörk, Thilo, Hillemanns, Peter, Dürst, Matthias, Runnebaum, Ingo B., Bogdanova, Natalia, Pelttari, Liisa M., Nevanlinna, Heli, Leminen, Arto, Edwards, Robert P., Kelley, Joseph L., Harter, Philipp, Schwaab, Ira, Heitz, Florian, du Bois, Andreas, Orsulic, Sandra, Lester, Jenny, Walsh, Christine, Karlan, Beth Y., Hogdall, Estrid, Kjaer, Susanne K., Jensen, Allan, Vierkant, Robert A., Cunningham, Julie M., Goode, Ellen L., Fridley, Brooke L., Southey, Melissa C., Giles, Graham G., Bruinsma, Fiona, Wu, Xifeng, Hildebrandt, Michelle A.T., Lu, Karen, Liang, Dong, Bisogna, Maria, Levine, Douglas A., Weber, Rachel Palmieri, Schildkraut, Joellen M., Iversen, Edwin S., Berchuck, Andrew, Terry, Kathryn L., Cramer, Daniel W., Tworoger, Shelley S., Poole, Elizabeth M., Olson, Sara H., Orlow, Irene, Bandera, Elisa V., Bjorge, Line, Tangen, Ingvild L., Salvesen, Helga B., Krakstad, Camilla, Massuger, Leon F.A.G., Kiemeney, Lambertus A., Aben, Katja K.H., van Altena, Anne M., Bean, Yukie, Pejovic, Tanja, Kellar, Melissa, Le, Nhu D., Cook, Linda S., Kelemen, Linda E., Brooks-Wilson, Angela, Lubinski, Jan, Gronwald, Jacek, Cybulski, Cezary, Jakubowska, Anna, Wentzensen, Nicolas, Brinton, Louise A., Lissowska, Jolanta, Yang, Hannah, Nedergaard, Lotte, Lundvall, Lene, Hogdall, Claus, Song, Honglin, Campbell, Ian G., Eccles, Diana, Glasspool, Rosalind, Siddiqui, Nadeem, Carty, Karen, Paul, James, McNeish, Iain A., Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H., Whittemore, Alice S., McLaughlin, John R., Risch, Harvey A., Phelan, Catherine M., Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Ramus, Susan J., Gentry-Maharaj, Aleksandra, Harrington, Patricia, Pike, Malcolm C., Modugno, Francesmary, Rossing, Mary Anne, Ness, Roberta B., Pharoah, Paul D.P., Stram, Daniel O., Wu, Anna H., and Pearce, Celeste Leigh

Published
2015
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58. Efficacy and safety of rucaparib treatment in patients with BRCA-mutated, relapsed ovarian cancer: final results from Study 10

Author

Kristeleit, Rebecca S., primary, Drew, Yvette, additional, Oza, Amit M., additional, Domchek, Susan M., additional, Banerjee, Susana, additional, Glasspool, Rosalind M., additional, Balmaña, Judith, additional, Chen, Lee-may, additional, Patel, Manish R., additional, Burris, Howard A., additional, Safra, Tamar, additional, Borrow, Jennifer, additional, Lin, Kevin K., additional, Goble, Sandra, additional, Maloney, Lara, additional, and Shapira-Frommer, Ronnie, additional

Published
2022
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59. O025/#522 Maintenance olaparib rechallenge in patients with ovarian cancer previously treated with a parp inhibitor: patient-reported outcomes from the phase IIIB OReO/engot-ov38 trial

Author

Redondo, Andrés, primary, Follana, Philippe, additional, Scambia, Giovanni, additional, Asselain, Bernard, additional, Marmé, Frederik, additional, Mirza, Mansoor, additional, Laudani, Maria Elena, additional, Mądry, Radosław, additional, Glasspool, Rosalind, additional, You, Benoit, additional, Rubio-Perez, María Jesús, additional, Zamagni, Claudio, additional, El-Balat, Ahmed, additional, Hardy-Bessard, Anne Claire, additional, Oaknin, Ana, additional, Ronzino, Graziana, additional, Shaw, Bob, additional, Nakamura, Hitomi, additional, Berton, Dominique, additional, and Pujade-Lauraine, Eric, additional

Published
2022
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61. EP336/#1095 Developing a central database and virtual biobank for rare gynaecological cancers in the UK: rango (rare neoplasms of gynaecological origin)

Author

Hall, Marcia, primary, Mcgrane, John, additional, Glasspool, Rosalind, additional, Jeyneethi, Jeyarooban, additional, Herbertson, Rebecca, additional, Bowen, Rebecca, additional, Saravi, Sayeh, additional, Rolland, Phillip, additional, Millar, Joanne, additional, Mcdonald, Thirza, additional, and Karteris, Emmanouil, additional

Published
2022
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62. TP030/#1426 EPIK-O/ENGOT-OV61: a phase 3, randomized study of alpelisib + olaparib in patients with no germline BRCA mutation detected, platinum-resistant or -refractory, high-grade serous ovarian cancer

Author

Konstantinopoulos, Panagiotis, primary, Gonzalez-Martin, Antonio, additional, Cruz, Felipe, additional, Friedlander, Michael, additional, Glasspool, Rosalind, additional, Lorusso, Domenica, additional, Marth, Christian, additional, Monk, Bradley, additional, Kim, Jae-Weon, additional, Ajipa, Olga, additional, Su, Faye, additional, Han, Yu, additional, and Matulonis, Ursula, additional

Published
2022
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63. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Author

Phelan, Catherine M, Kuchenbaecker, Karoline B, Tyrer, Jonathan P, Kar, Siddhartha P, Lawrenson, Kate, Winham, Stacey J, Dennis, Joe, Pirie, Ailith, Riggan, Marjorie J, Chornokur, Ganna, Earp, Madalene A, Lyra, Jr, Paulo C, Lee, Janet M, Coetzee, Simon, Beesley, Jonathan, McGuffog, Lesley, Soucy, Penny, Dicks, Ed, Lee, Andrew, Barrowdale, Daniel, Lecarpentier, Julie, Leslie, Goska, Aalfs, Cora M, Aben, Katja K H, Adams, Marcia, Adlard, Julian, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia, Aravantinos, Gerasimos, Arnold, Norbert, Arun, Banu K, Arver, Brita, Azzollini, Jacopo, Balmaña, Judith, Banerjee, Susana N, Barjhoux, Laure, Barkardottir, Rosa B, Bean, Yukie, Beckmann, Matthias W, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q, Birrer, Michael J, Bjorge, Line, Black, Amanda, Blankstein, Kenneth, Blok, Marinus J, Bodelon, Clara, Bogdanova, Natalia, Bojesen, Anders, Bonanni, Bernardo, Borg, Åke, Bradbury, Angela R, Brenton, James D, Brewer, Carole, Brinton, Louise, Broberg, Per, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Buecher, Bruno, Butzow, Ralf, Buys, Saundra S, Caldes, Trinidad, Caligo, Maria A, Campbell, Ian, Cannioto, Rikki, Carney, Michael E, Cescon, Terence, Chan, Salina B, Chang-Claude, Jenny, Chanock, Stephen, Chen, Xiao Qing, Chiew, Yoke-Eng, Chiquette, Jocelyne, Chung, Wendy K, Claes, Kathleen B M, Conner, Thomas, Cook, Linda S, Cook, Jackie, Cramer, Daniel W, Cunningham, Julie M, D'Aloisio, Aimee A, Daly, Mary B, Damiola, Francesca, Damirovna, Sakaeva Dina, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Davidson, Rosemarie, DeFazio, Anna, Delnatte, Capucine, Doheny, Kimberly F, Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer Anne, Domchek, Susan M, Dorfling, Cecilia M, Dörk, Thilo, Dossus, Laure, Duran, Mercedes, Dürst, Matthias, Dworniczak, Bernd, Eccles, Diana, Edwards, Todd, Eeles, Ros, Eilber, Ursula, Ejlertsen, Bent, Ekici, Arif B, Ellis, Steve, Elvira, Mingajeva, Eng, Kevin H, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Ferguson, Sarah, Ferrer, Sandra Fert, Flanagan, James M, Fogarty, Zachary C, Fortner, Renée T, Fostira, Florentia, Foulkes, William D, Fountzilas, George, Fridley, Brooke L, Friebel, Tara M, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, García, María J, Garcia-Barberan, Vanesa, Gehrig, Andrea, Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G, Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K, Goldgar, David E, Goranova, Teodora, Gore, Martin, Greene, Mark H, Gronwald, Jacek, Gruber, Stephen, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hamann, Ute, Hansen, Thomas V O, Harrington, Patricia A, Harris, Holly R, Hauke, Jan, Hein, Alexander, Henderson, Alex, Hildebrandt, Michelle A T, Hillemanns, Peter, Hodgson, Shirley, Høgdall, Claus K, Høgdall, Estrid, Hogervorst, Frans B L, Holland, Helene, Hooning, Maartje J, Hosking, Karen, Huang, Ruea-Yea, Hulick, Peter J, Hung, Jillian, Hunter, David J, Huntsman, David G, Huzarski, Tomasz, Imyanitov, Evgeny N, Isaacs, Claudine, Iversen, Edwin S, Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jernetz, Mats, Jensen, Allan, Jensen, Uffe Birk, John, Esther M, Johnatty, Sharon, Jones, Michael E, Kannisto, Päivi, Karlan, Beth Y, Karnezis, Anthony, Kast, Karin, Kennedy, Catherine J, Khusnutdinova, Elza, Kiemeney, Lambertus A, Kiiski, Johanna I, Kim, Sung-Won, Kjaer, Susanne K, Köbel, Martin, Kopperud, Reidun K, Kruse, Torben A, Kupryjanczyk, Jolanta, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Larrañaga, Nerea, Larson, Melissa C, Lazaro, Conxi, Le, Nhu D, Le Marchand, Loic, Lee, Jong Won, Lele, Shashikant B, Leminen, Arto, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A, Liang, Dong, Liebrich, Clemens, Lilyquist, Jenna, Lipworth, Loren, Lissowska, Jolanta, Lu, Karen H, Lubinński, Jan, Luccarini, Craig, Lundvall, Lene, Mai, Phuong L, Mendoza-Fandiño, Gustavo, Manoukian, Siranoush, Massuger, Leon F A G, May, Taymaa, Mazoyer, Sylvie, McAlpine, Jessica N, McGuire, Valerie, McLaughlin, John R, McNeish, Iain, Meijers-Heijboer, Hanne, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R, Merritt, Melissa A, Milne, Roger L, Mitchell, Gillian, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moffitt, Melissa, Montagna, Marco, Moysich, Kirsten B, Mulligan, Anna Marie, Musinsky, Jacob, Nathanson, Katherine L, Nedergaard, Lotte, Ness, Roberta B, Neuhausen, Susan L, Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L, Odunsi, Kunle, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Olswold, Curtis, O'Malley, David M, Ong, Kai-ren, Onland-Moret, N Charlotte, Orr, Nicholas, Orsulic, Sandra, Osorio, Ana, Palli, Domenico, Papi, Laura, Park-Simon, Tjoung-Won, Paul, James, Pearce, Celeste L, Pedersen, Inge Søkilde, Peeters, Petra H M, Peissel, Bernard, Peixoto, Ana, Pejovic, Tanja, Pelttari, Liisa M, Permuth, Jennifer B, Peterlongo, Paolo, Pezzani, Lidia, Pfeiler, Georg, Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C, Piskorz, Anna M, Poblete, Samantha R, Pocza, Timea, Poole, Elizabeth M, Poppe, Bruce, Porteous, Mary E, Prieur, Fabienne, Prokofyeva, Darya, Pugh, Elizabeth, Pujana, Miquel Angel, Pujol, Pascal, Radice, Paolo, Rantala, Johanna, Rappaport-Fuerhauser, Christine, Rennert, Gad, Rhiem, Kerstin, Rice, Patricia, Richardson, Andrea, Robson, Mark, Rodriguez, Gustavo C, Rodríguez-Antona, Cristina, Romm, Jane, Rookus, Matti A, Rossing, Mary Anne, Rothstein, Joseph H, Rudolph, Anja, Runnebaum, Ingo B, Salvesen, Helga B, Sandler, Dale P, Schoemaker, Minouk J, Senter, Leigha, Setiawan, V Wendy, Severi, Gianluca, Sharma, Priyanka, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E, Sieh, Weiva, Singer, Christian F, Sobol, Hagay, Song, Honglin, Southey, Melissa C, Spurdle, Amanda B, Stadler, Zsofia, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sucheston-Campbell, Lara E, Sukiennicki, Grzegorz, Sutphen, Rebecca, Sutter, Christian, Swerdlow, Anthony J, Szabo, Csilla I, Szafron, Lukasz, Tan, Yen Y, Taylor, Jack A, Tea, Muy-Kheng, Teixeira, Manuel R, Teo, Soo-Hwang, Terry, Kathryn L, Thompson, Pamela J, Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L, Tihomirova, Laima, Tinker, Anna V, Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda Ewart, Tone, Alicia, Trabert, Britton, Travis, Ruth C, Trichopoulou, Antonia, Tung, Nadine, Tworoger, Shelley S, van Altena, Anne M, Van Den Berg, David, van der Hout, Annemarie H, van der Luijt, Rob B, Van Heetvelde, Mattias, Van Nieuwenhuysen, Els, van Rensburg, Elizabeth J, Vanderstichele, Adriaan, Varon-Mateeva, Raymonda, Vega, Ana, Edwards, Digna Velez, Vergote, Ignace, Vierkant, Robert A, Vijai, Joseph, Vratimos, Athanassios, Walker, Lisa, Walsh, Christine, Wand, Dorothea, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Webb, Penelope M, Weinberg, Clarice R, Weitzel, Jeffrey N, Wentzensen, Nicolas, Whittemore, Alice S, Wijnen, Juul T, Wilkens, Lynne R, Wolk, Alicja, Woo, Michelle, Wu, Xifeng, Wu, Anna H, Yang, Hannah, Yannoukakos, Drakoulis, Ziogas, Argyrios, Zorn, Kristin K, Narod, Steven A, Easton, Douglas F, Amos, Christopher I, Schildkraut, Joellen M, Ramus, Susan J, Ottini, Laura, Goodman, Marc T, Park, Sue K, Kelemen, Linda E, Risch, Harvey A, Thomassen, Mads, Offit, Kenneth, Simard, Jacques, Schmutzler, Rita Katharina, Hazelett, Dennis, Monteiro, Alvaro N, Couch, Fergus J, Berchuck, Andrew, Chenevix-Trench, Georgia, Goode, Ellen L, Sellers, Thomas A, Gayther, Simon A, Antoniou, Antonis C, and Pharoah, Paul D P

Published
2017
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64. EPIK-O/ENGOT-OV61: alpelisib plus olaparib vs cytotoxic chemotherapy in high-grade serous ovarian cancer (phase III study)

Author

Konstantinopoulos, Panagiotis A, primary, Gonzalez-Martin, Antonio, additional, Cruz, Felipe Melo, additional, Friedlander, Michael, additional, Glasspool, Rosalind, additional, Lorusso, Domenica, additional, Marth, Christian, additional, Monk, Bradley J, additional, Kim, Jae-Weon, additional, Hinson, Patsy, additional, Ajipa, Olga, additional, Pretre, Vincent, additional, Han, Yu, additional, and Matulonis, Ursula A, additional

Published
2022
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65. Investigating the Impact of Ultra-Radical Surgery on Survival in Advanced Ovarian Cancer Using Population-Based Data in a Multicentre UK Study

Author

Cummins, Carole, primary, Kumar, Satyam, additional, Long, Joanna, additional, Balega, Janos, additional, Broadhead, Tim, additional, Duncan, Timothy, additional, Edmondson, Richard J., additional, Fotopoulou, Christina, additional, Glasspool, Rosalind M., additional, Kolomainen, Desiree, additional, Leeson, Simon, additional, Manchanda, Ranjit, additional, Morrison, Jo, additional, Naik, Raj, additional, Tidy, John A., additional, Wood, Nick, additional, and Sundar, Sudha, additional

Published
2022
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66. Maintenance olaparib in patients (pts) with platinum-sensitive relapsed ovarian cancer (PSROC) by somatic (s) or germline (g) BRCA and other homologous recombination repair (HRR) gene mutation status: Overall survival (OS) results from the ORZORA study.

Author

Pignata, Sandro, primary, Oza, Amit M., additional, Hall, Geoff, additional, Pardo, Beatriz, additional, Madry, Radoslaw, additional, Cibula, David, additional, Klat, Jaroslav, additional, Montes, Ana, additional, Glasspool, Rosalind, additional, Colombo, Nicoletta, additional, Pete, Imre, additional, Herrero, Ana, additional, Romeo, Marga, additional, Ilieva, Rumyana Nedyalkova, additional, Timcheva, Constanta, additional, Di Maio, Massimo, additional, Barnicle, Alan, additional, Taylor, Rosemary, additional, Bashir, Zahid, additional, and Clamp, Andrew R., additional

Published
2022
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67. OReO/ENGOT Ov-38 trial: Impact of maintenance olaparib rechallenge according to ovarian cancer patient prognosis—An exploratory joint analysis of the BRCA and non-BRCA cohorts.

Author

Selle, Frederic, primary, Asselain, Bernard, additional, Montestruc, François, additional, Bazan, Fernando, additional, Pardo, Beatriz, additional, Salutari, Vanda, additional, Marmé, Frederik, additional, Ør Knudsen, Anja, additional, Bologna, Alessandra, additional, Madry, Radoslaw, additional, Glasspool, Rosalind, additional, Henry, Stéphanie, additional, Korach, Jacob, additional, Lheureux, Stephanie, additional, Shaw, Bob, additional, Santaballa, Ana, additional, Cioffi, Raffaella, additional, Canzler, Ulrich, additional, Lortholary, Alain, additional, and Pujade-Lauraine, Eric, additional

Published
2022
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68. A Randomised, Multi-centre Phase II Trial of Weekly Paclitaxel and Vistusertib in Platinum-Resistant Ovarian High-Grade Serous Carcinoma: OCTOPUS Arm 1

Author

Banerjee, Susana, primary, Giannone, Gaia, additional, Clamp, Andrew, additional, Glasspool, Rosalind M., additional, Herbertson, Rebecca, additional, Krell, Jonathan, additional, Riisnaes, Ruth, additional, Ennis, Darren P, additional, Mirza, Hasan B, additional, Cheng, Zhao, additional, McDermott, Jacqueline, additional, Green, Clare, additional, Kristeleit, Rebecca, additional, George, Angela, additional, Gourley, Charlie, additional, Lewsley, Liz-Anne, additional, Rai, Debbie, additional, Banerji, Udai, additional, Hinsley, Samantha, additional, and McNeish, Iain A, additional

Published
2022
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69. BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers

Author

Meeks, Huong D., Song, Honglin, Michailidou, Kyriaki, Bolla, Manjeet K., Dennis, Joe, Wang, Qin, Barrowdale, Daniel, Frost, Debra, McGuffog, Lesley, Ellis, Steve, Feng, Bingjian, Buys, Saundra S., Hopper, John L., Southey, Melissa C., Tesoriero, Andrea, James, Paul A., Bruinsma, Fiona, Campbell, Ian G., Broeks, Annegien, Schmidt, Marjanka K., Hogervorst, Frans B. L., Beckman, Matthias W., Fasching, Peter A., Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor J., Riboli, Elio, Banerjee, Susana, Menon, Usha, Tomlinson, Ian, Burwinkel, Barbara, Hamann, Ute, Marme, Frederik, Rudolph, Anja, Janavicius, Ramunas, Tihomirova, Laima, Tung, Nadine, Garber, Judy, Cramer, Daniel, Terry, Kathryn L., Poole, Elizabeth M., Tworoger, Shelley S., Dorfling, Cecilia M., van Rensburg, Elizabeth J., Godwin, Andrew K., Guénel, Pascal, Truong, Thérèse, Stoppa-Lyonnet, Dominique, Damiola, Francesca, Mazoyer, Sylvie, Sinilnikova, Olga M., Isaacs, Claudine, Maugard, Christine, Bojesen, Stig E., Flyger, Henrik, Gerdes, Anne-Marie, Hansen, Thomas V. O., Jensen, Allen, Kjaer, Susanne K., Hogdall, Claus, Hogdall, Estrid, Pedersen, Inge Sokilde, Thomassen, Mads, Benitez, Javier, González-Neira, Anna, Osorio, Ana, Hoya, Miguel de la, Segura, Pedro Perez, Diez, Orland, Lazaro, Conxi, Brunet, Joan, Anton-Culver, Hoda, Eunjung, Lee, John, Esther M., Neuhausen, Susan L., Ding, Yuan Chun, Castillo, Danielle, Weitzel, Jeffrey N., Ganz, Patricia A., Nussbaum, Robert L., Chan, Salina B., Karlan, Beth Y., Lester, Jenny, Wu, Anna, Gayther, Simon, Ramus, Susan J., Sieh, Weiva, Whittermore, Alice S., Monteiro, Alvaro N. A., Phelan, Catherine M., Terry, Mary Beth, Piedmonte, Marion, Offit, Kenneth, Robson, Mark, Levine, Douglas, Moysich, Kirsten B., Cannioto, Rikki, Olson, Sara H., Daly, Mary B., Nathanson, Katherine L., Domchek, Susan M., Lu, Karen H., Liang, Dong, Hildebrant, Michelle A. T., Ness, Roberta, Modugno, Francesmary, Pearce, Leigh, Goodman, Marc T., Thompson, Pamela J., Brenner, Hermann, Butterbach, Katja, Meindl, Alfons, Hahnen, Eric, Wappenschmidt, Barbara, Brauch, Hiltrud, Brüning, Thomas, Blomqvist, Carl, Khan, Sofia, Nevanlinna, Heli, Pelttari, Liisa M., Aittomäki, Kristiina, Butzow, Ralf, Bogdanova, Natalia V., Dörk, Thilo, Lindblom, Annika, Margolin, Sara, Rantala, Johanna, Kosma, Veli-Matti, Mannermaa, Arto, Lambrechts, Diether, Neven, Patrick, Claes, Kathleen B. M., Maerken, Tom Van, Chang-Claude, Jenny, Flesch-Janys, Dieter, Heitz, Florian, Varon-Mateeva, Raymonda, Peterlongo, Paolo, Radice, Paolo, Viel, Alessandra, Barile, Monica, Peissel, Bernard, Manoukian, Siranoush, Montagna, Marco, Oliani, Cristina, Peixoto, Ana, Teixeira, Manuel R., Collavoli, Anita, Hallberg, Emily, Olson, Janet E., Goode, Ellen L., Hart, Steven N., Shimelis, Hermela, Cunningham, Julie M., Giles, Graham G., Milne, Roger L., Healey, Sue, Tucker, Kathy, Haiman, Christopher A., Henderson, Brian E., Goldberg, Mark S., Tischkowitz, Marc, Simard, Jacques, Soucy, Penny, Eccles, Diana M., Le, Nhu, Borresen-Dale, Anne-Lise, Kristensen, Vessela, Salvesen, Helga B., Bjorge, Line, Bandera, Elisa V., Risch, Harvey, Zheng, Wei, Beeghly-Fadiel, Alicia, Cai, Hui, Pylkäs, Katri, Tollenaar, Robert A. E. M., Ouweland, Ans M. W. van der, Andrulis, Irene L., Knight, Julia A., Narod, Steven, Devilee, Peter, Winqvist, Robert, Figueroa, Jonine, Greene, Mark H., Mai, Phuong L., Loud, Jennifer T., García-Closas, Montserrat, Schoemaker, Minouk J., Czene, Kamila, Darabi, Hatef, McNeish, Iain, Siddiquil, Nadeem, Glasspool, Rosalind, Kwong, Ava, Park, Sue K., Teo, Soo Hwang, Yoon, Sook-Yee, Matsuo, Keitaro, Hosono, Satoyo, Woo, Yin Ling, Gao, Yu-Tang, Foretova, Lenka, Singer, Christian F., Rappaport-Feurhauser, Christine, Friedman, Eitan, Laitman, Yael, Rennert, Gad, Imyanitov, Evgeny N., Hulick, Peter J., Olopade, Olufunmilayo I., Senter, Leigha, Olah, Edith, Doherty, Jennifer A., Schildkraut, Joellen, Koppert, Linetta B., Kiemeney, Lambertus A., Massuger, Leon F. A. G., Cook, Linda S., Pejovic, Tanja, Li, Jingmei, Borg, Ake, Öfverholm, Anna, Rossing, Mary Anne, Wentzensen, Nicolas, Henriksson, Karin, Cox, Angela, Cross, Simon S., Pasini, Barbara J., Shah, Mitul, Kabisch, Maria, Torres, Diana, Jakubowska, Anna, Lubinski, Jan, Gronwald, Jacek, Agnarsson, Bjarni A., Kupryjanczyk, Jolanta, Moes-Sosnowska, Joanna, Fostira, Florentia, Konstantopoulou, Irene, Slager, Susan, Jones, Michael, Antoniou, Antonis C., Berchuck, Andrew, Swerdlow, Anthony, Chenevix-Trench, Georgia, Dunning, Alison M., Pharoah, Paul D. P., Hall, Per, Easton, Douglas F., Couch, Fergus J., Spurdle, Amanda B., and Goldgar, David E.

Published
2016
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70. Modifiable pre-treatment factors are associated with quality of life in women with gynaecological cancers at diagnosis and one year later: Results from the HORIZONS UK national cohort study

Author

Glasspool, Rosalind, primary, Wheelwright, Sally, additional, Bolton, Victoria, additional, Calman, Lynn, additional, Cummings, Amanda, additional, Elledge, Beryl, additional, Foster, Rebecca, additional, Frankland, Jane, additional, Smith, Peter, additional, Stannard, Sebastian, additional, Turner, Joshua, additional, Wright, David, additional, and Foster, Claire, additional

Published
2022
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72. Survival Prognostic and Surrogate Values of the Early Modeled Ca-125 Kelim Score in First-Line Treatment of Ovarian Cancer: Results from The Gcig Individual Patient Data Meta-Analysis

Author

Corbaux, Pauline, primary, You, Benoit, additional, Glasspool, Rosalind M., additional, Yanaihara, Nozomu, additional, Tinker, Anna V., additional, Lindemann, Kristina, additional, Ray-Coquard, Isabelle-Laure, additional, Mirza, Mansoor Raza, additional, Subtil, Fabien, additional, Colomban, Olivier, additional, Péron, Julien, additional, Karamouza, Eleni, additional, McNeish, Iain, additional, Hinsley, Samantha, additional, Kagimura, Tatsuo, additional, Welch, Stephen, additional, Lewsley, Liz-Anne, additional, Paoletti, Xavier, additional, and Cook, Adrian, additional

Published
2022
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74. ORZORA: Maintenance olaparib in patients with platinum-sensitive relapsed ovarian cancer: outcomes by somatic and germline BRCA and other homologous recombination repair gene mutation status

Author

Pignata, Sandro, primary, Oza, Amit, additional, Hall, Geoff, additional, Pardo, Beatriz, additional, Madry, Radoslaw, additional, Cibula, David, additional, Klat, Jaroslav, additional, Montes, Ana, additional, Glasspool, Rosalind, additional, Colombo, Nicoletta, additional, Pete, Imre, additional, Herrero, Ana, additional, Marin, Margarita Romeo, additional, Ilieva, Rumyana, additional, Timcheva, Constanta, additional, Blakeley, Christopher, additional, Taylor, Rosie, additional, Barnicle, Alan, additional, and Clamp, Andrew, additional

Published
2021
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76. Identification of a Locus Near ULK1 Associated With Progression-Free Survival in Ovarian Cancer

Author

Quinn, Michael C. J., McCue, Karen, Shi, Wei, Johnatty, Sharon E., Beesley, Jonathan, Civitarese, Andrew, O'Mara, Tracy A., Glubb, Dylan M., Tyrer, Jonathan P., Armasu, Sebastian M., Ong, Jue-Sheng, Gharahkhani, Puya, Gao, Bo, Patch, Ann-Marie, Fasching, Peter A., Beckmann, Matthias W., Lambrechts, Diether, Vergote, Ignace, Edwards, Digna R. Velez, Beeghly-Fadiel, Alicia, Benitez, Javier, Garcia, Maria J., Goodman, Marc T., Doerk, Thilo, Duerst, Matthias, Modugno, Francesmary, Moysich, Kirsten, du Bois, Andreas, Pfisterer, Jacobus, Bauman, Klaus, Karlan, Beth Y., Lester, Jenny, Cunningham, Julie M., Larson, Melissa C., McCauley, Bryan M., Kjaer, Susanne K., Jensen, Allan, Hogdall, Claus K., Hogdall, Estrid, Schildkraut, Joellen M., Riggan, Marjorie J., Berchuck, Andrew, Cramer, Daniel W., Terry, Kathryn L., Bjorge, Line, Webb, Penelope M., Friedlander, Michael, Pejovic, Tanja, Moffitt, Melissa, Glasspool, Rosalind, Quinn, Michael C. J., McCue, Karen, Shi, Wei, Johnatty, Sharon E., Beesley, Jonathan, Civitarese, Andrew, O'Mara, Tracy A., Glubb, Dylan M., Tyrer, Jonathan P., Armasu, Sebastian M., Ong, Jue-Sheng, Gharahkhani, Puya, Gao, Bo, Patch, Ann-Marie, Fasching, Peter A., Beckmann, Matthias W., Lambrechts, Diether, Vergote, Ignace, Edwards, Digna R. Velez, Beeghly-Fadiel, Alicia, Benitez, Javier, Garcia, Maria J., Goodman, Marc T., Doerk, Thilo, Duerst, Matthias, Modugno, Francesmary, Moysich, Kirsten, du Bois, Andreas, Pfisterer, Jacobus, Bauman, Klaus, Karlan, Beth Y., Lester, Jenny, Cunningham, Julie M., Larson, Melissa C., McCauley, Bryan M., Kjaer, Susanne K., Jensen, Allan, Hogdall, Claus K., Hogdall, Estrid, Schildkraut, Joellen M., Riggan, Marjorie J., Berchuck, Andrew, Cramer, Daniel W., Terry, Kathryn L., Bjorge, Line, Webb, Penelope M., Friedlander, Michael, Pejovic, Tanja, Moffitt, Melissa, and Glasspool, Rosalind

Abstract

Background: Many loci have been found to be associated with risk of epithelial ovarian cancer (EOC). However, although there is considerable variation in progression-free survival (PFS), no loci have been found to be associated with outcome at genome-wide levels of significance.Methods: We carried out a genome-wide association study (GWAS) of PFS in 2,352 women with EOC who had undergone cytoreductive surgery and standard carboplatin/paclitaxel chemotherapy.Results: We found seven SNPs at 12q24.33 associated with PFS (P < 5 x 10(-8)), the top SNP being rs10794418 (HR = 1.24; 95% CI, 1.15-1.34; P = 1.47 x 10(-8)). High expression of a nearby gene, ULK1, is associated with shorter PFS in EOC, and with poor prognosis in other cancers. SNP rs10794418 is also associated with expression of ULK1 in ovarian tumors, with the allele associated with shorter PFS being associated with higher expression, and chromatin interactions were detected between the ULK1 promoter and associated SNPs in serous and endometrioid EOC cell lines. ULK1 knockout ovarian cancer cell lines showed significantly increased sensitivity to carboplatin in vitro.Conclusions: The locus at 12q24.33 represents one of the first genome-wide significant loci for survival for any cancer. ULK1 is a plausible candidate for the target of this association.Impact: This finding provides insight into genetic markers associated with EOC outcome and potential treatment options.

Published
2021

77. Corrigendum to “Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data” Gynecol. Oncol. 154 (2019) 441–448

Author

Cohen, Paul A., primary, Powell, Aime, additional, Böhm, Steffen, additional, Gilks, C. Blake, additional, Stewart, Colin J.R., additional, Meniawy, Tarek M., additional, Bulsara, Max, additional, Avril, Stefanie, additional, Brockbank, Eleanor C., additional, Bosse, Tjalling, additional, de Azevedo Focchi, Gustavo Rubino, additional, Ganesan, Raji, additional, Glasspool, Rosalind M., additional, Howitt, Brooke E., additional, Kim, Hyun-Soo, additional, Lee, Jung-Yun, additional, Le, Nhu D., additional, Lockley, Michelle, additional, Manchanda, Ranjit, additional, Mandalia, Trupti, additional, McCluggage, W. Glenn, additional, McNeish, Iain, additional, Midha, Divya, additional, Srinivasan, Radhika, additional, Tan, Yun Yi, additional, van der Griend, Rachael, additional, Yunokawa, Mayu, additional, Zannoni, Gian F., additional, and Singh, Naveena, additional

Published
2021
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78. Assessment of progression-free survival as a surrogate end point of overall survival in first-line treatment of ovarian cancer

Author

Paoletti, Xavier, Lewsley, Liz-Anne, Daniele, Gennaro, Cook, Adrian, Yanaihara, Nozomu, Tinker, Anna, Kristensen, Gunnar, Ottevanger, Petronella B., Aravantinos, Gerasimos, Miller, Austin, Boere, Ingrid A., Fruscio, Robert, Reyners, Anna K. L., Pujade-Lauraine, Eric, Harkin, Andrea, Pignata, Sandro, Kagimura, Tatsuo, Welch, Stephen, Paul, James, Karamouza, Eleni, and Glasspool, Rosalind M.

Abstract

Importance: The Gynecologic Cancer InterGroup (GCIG) recommended that progression-free survival (PFS) can serve as a primary end point instead of overall survival (OS) in advanced ovarian cancer. Evidence is lacking for the validity of PFS as a surrogate marker of OS in the modern era of different treatment types.\ud \ud Objective: To evaluate whether PFS is a surrogate end point for OS in patients with advanced ovarian cancer.\ud \ud Data Sources: In September 2016, a comprehensive search of publications in MEDLINE was conducted for randomized clinical trials of systematic treatment in patients with newly diagnosed ovarian, fallopian tube, or primary peritoneal cancer. The GCIG groups were also queried for potentially completed but unpublished trials.\ud \ud Study Selection: Studies with a minimum sample size of 60 patients published since 2001 with PFS and OS rates available were eligible. Investigational treatments considered included initial, maintenance, and intensification therapy consisting of agents delivered at a higher dose and/or frequency compared with that in the control arm.\ud \ud Data Extraction and Synthesis: Using the meta-analytic approach on randomized clinical trials published from January 1, 2001, through September 25, 2016, correlations between PFS and OS at the individual level were estimated using the Kendall τ model; between-treatment effects on PFS and OS at the trial level were estimated using the Plackett copula bivariate (R2) model. Criteria for PFS surrogacy required R2 ≥ 0.80 at the trial level. Analysis was performed from January 7 through March 20, 2019.\ud \ud Main Outcomes and Measures: Overall survival and PFS based on measurement of cancer antigen 125 levels confirmed by radiological examination results or by combined GCIG criteria.\ud \ud Results: In this meta-analysis of 17 unique randomized trials of standard (n = 7), intensification (n = 5), and maintenance (n = 5) chemotherapies or targeted treatments with data from 11 029 unique patients (median age, 58 years [range, 18-88 years]), a high correlation was found between PFS and OS at the individual level (τ = 0.724; 95% CI, 0.717-0.732), but a low correlation was found at the trial level (R2 = 0.24; 95% CI, 0-0.59). Subgroup analyses led to similar results. In the external validation, 14 of the 16 hazard ratios for OS in the published reports fell within the 95% prediction interval from PFS.\ud \ud Conclusions and Relevance: This large meta-analysis of individual patient data did not establish PFS as a surrogate end point for OS in first-line treatment of advanced ovarian cancer, but the analysis was limited by the narrow range of treatment effects observed or by poststudy treatment. These results suggest that if PFS is chosen as a primary end point, OS must be measured as a secondary end point.

Published
2020

79. COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA

Author

Macintyre, Geoff, Goranova, Teodora E., De Silva, Dilrini, Ennis, Darren, Piskorz, Anna M., Eldridge, Matthew, Sie, Daoud, Lewsley, Liz-Anne, Hanif, Aishah, Wilson, Cheryl, Dowson, Suzanne, Glasspool, Rosalind M., Lockley, Michelle, Brockbank, Elly, Montes, Ana, Walther, Axel, Sundar, Sudha, Edmondson, Richard, Hall, Geoff D., Clamp, Andrew, Gourley, Charlie, Hall, Marcia, Fotopoulou, Christina, Gabra, Hani, Paul, James, Supernat, Anna, Millan, David, Hoyle, Aoisha, Bryson, Gareth, Nourse, Craig, Mincarelli, Laura, Sanchez, Luis Navarro, Ylstra, Bauke, Jimenez-Linan, Mercedes, Moore, Luiza, Hofmann, Oliver, Markowetz, Florian, McNeish, Iain A., Brenton, James D., Human genetics, CCA - Cancer biology and immunology, and Pathology

Published
2019

80. 596 A randomised phase II study of nintedanib (BIBF1120) compared to chemotherapy in patients with recurrent clear cell carcinoma of the ovary or endometrium. (NICCC/ENGOT-OV36)

Author

Glasspool, Rosalind, primary, Mcneish, Iain, additional, Westermann, Anneke, additional, Hinsley, Samantha, additional, Ledermann, Jonathan, additional, Ray-Coquard, Isabelle, additional, Lawless, Claire, additional, Ottevanger, Nelleke, additional, Mirza, Mansoor Raza, additional, and Alexandre, Jerome, additional

Published
2020
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82. ENGOT-OV44/FIRST study: a randomized, double-blind, adaptive, phase III study of standard of care (SOC) platinum-based therapy ± dostarlimab followed by niraparib ± dostarlimab maintenance as first-line (1L) treatment of stage 3 or 4 ovarian cancer (OC).

Author

Hardy-Bessard, Anne-Claire, primary, Moore, Kathleen N., additional, Mirza, Mansoor Raza, additional, Asselain, Bernard, additional, Redondo, Andres, additional, Pfisterer, Jacobus, additional, Pignata, Sandro, additional, Provencher, Diane M., additional, Cibula, David, additional, Reyners, Anna K.L., additional, Bodnar, Lubomir, additional, Glasspool, Rosalind, additional, Papadimitriou, Christos, additional, Eitan, Rami, additional, Han, Sileny N., additional, Duska, Linda R., additional, Rimel, BJ, additional, Divya, Gupta, additional, Chen, Jian, additional, and Pujade-Lauraine, Eric, additional

Published
2020
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83. Corrigendum to “Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data” [Gynecol. Oncol. 154 (2019) 441–448]

Author

Cohen, Paul A., primary, Powell, Aime, additional, Böhm, Steffen, additional, Gilks, C. Blake, additional, Stewart, Colin J.R., additional, Meniawy, Tarek M., additional, Bulsara, Max, additional, Avril, Stefanie, additional, Brockbank, Eleanor C., additional, Bosse, Tjalling, additional, de Azevedo Focchi, Gustavo Rubino, additional, Ganesan, Raji, additional, Glasspool, Rosalind M., additional, Howitt, Brooke E., additional, Kim, Hyun-Soo, additional, Lee, Jung-Yun, additional, Le, Nhu D., additional, Lockley, Michelle, additional, Manchanda, Ranjit, additional, Mandalia, Trupti, additional, McCluggage, W. Glenn, additional, McNeish, Iain, additional, Midha, Divya, additional, Srinivasan, Radhika, additional, Tan, Yun Yi, additional, van der Griend, Rachael, additional, Yunokawa, Mayu, additional, Zannoni, Gian F., additional, and Singh, Naveena, additional

Published
2020
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84. Bevacizumab and platinum-based combinations for recurrent ovarian cancer: a randomised, open-label, phase 3 trial

Author

Pfisterer, Jacobus, primary, Shannon, Catherine M, additional, Baumann, Klaus, additional, Rau, Joern, additional, Harter, Philipp, additional, Joly, Florence, additional, Sehouli, Jalid, additional, Canzler, Ulrich, additional, Schmalfeldt, Barbara, additional, Dean, Andrew P, additional, Hein, Alexander, additional, Zeimet, Alain G, additional, Hanker, Lars C, additional, Petit, Thierry, additional, Marmé, Frederik, additional, El-Balat, Ahmed, additional, Glasspool, Rosalind, additional, de Gregorio, Nikolaus, additional, Mahner, Sven, additional, Meniawy, Tarek M, additional, Park-Simon, Tjoung-Won, additional, Mouret-Reynier, Marie-Ange, additional, Costan, Cristina, additional, Meier, Werner, additional, Reinthaller, Alexander, additional, Goh, Jeffrey C, additional, L'Haridon, Tifenn, additional, Baron Hay, Sally, additional, Kommoss, Stefan, additional, du Bois, Andreas, additional, Kurtz, Jean-Emmanuel, additional, Ackermann, Sven, additional, Anthuber, Christoph, additional, Aydogdu, Mustafa, additional, Baldauf, Angelika, additional, Bauer, Wolfgang, additional, Behringer, Dirk, additional, Belau, Antje, additional, Bender, Alexandra, additional, Brucker, Cosima, additional, Burges, Alexander, additional, Daabach, Trygve, additional, Denschlag, Dominik, additional, Deryal, Mustafa, additional, Dörfel, Steffen, additional, Ebert, Juliane, additional, Fehm, Tanja, additional, Feidicker, Susanne Maria, additional, Feisel-Schwickardi, Gabriele, additional, Felberbaum, Ricardo, additional, Frank, Matthias, additional, Gebauer, Gerhard, additional, Gerber, Bernd, additional, Gerhardt, Axel, additional, Grafe, Andrea, additional, Griesshammer, Martin, additional, Grischke, Eva-Maria, additional, Gröll, Isolde, additional, Gropp-Meier, Martina, additional, Hager, Dietrich, additional, Hanf, Volker, additional, Hannig, Carla Verena, additional, Hantschmann, Peer, additional, Hauzenberger, Tanja, additional, Herwig, Uwe, additional, Heubner, Martin, additional, Hielscher, Carsten, additional, Hilpert, Felix, additional, Hitschold, Thomas, additional, Hofmann, Manfred, additional, Jackisch, Christian, additional, Janni, Wolfgang, additional, Kiesel, Ludwig, additional, Ko, Yon-Dschun, additional, Koch, Hans-Joachim, additional, Krabisch, Petra, additional, Krieger, Peter, additional, Kubin, Thomas, additional, Kühn, Thorsten, additional, Lampe, Björn, additional, Ledwon, Peter, additional, Lemster, Sabine, additional, Lex, Benno, additional, Liebrich, Clemens, additional, Lorenz, Ralf, additional, Lück, Hans-Joachim, additional, Mallmann, Peter, additional, Meinerz, Wolfgang, additional, Menke, Götz, additional, Möbus, Volker, additional, Müller, Thomas, additional, Müller, Volker, additional, Neunhöffer, Tanja, additional, Ober, Angelika, additional, Oskay-Özcelik, Gülten, additional, Ostertag, Horst, additional, Pölcher, Martin, additional, Rautenberg, Beate, additional, Rein, Daniel, additional, Reiter, Wilhelm, additional, Rempen, Andreas, additional, Runnebaum, Ingo, additional, Schmidt, Marcus, additional, Schnohr, Sabine, additional, Scholz, Heinz, additional, Schröder, Willibald, additional, Simon, Eike, additional, Sperfeld, Antje, additional, Steckkönig, Annette, additional, Strauß, Hans-Georg, additional, Stuth, Ronaldo, additional, Terhaag, Jürgen, additional, Thiel, Falk, additional, Thill, Marc, additional, Tomé, Oliver, additional, Uleer, Christoph, additional, Vogel, Susanne, additional, Voß, Hermann, additional, Weigel, Michael, additional, Winkler, Ulrich, additional, Wischnik, Arthur, additional, Zeiser, Tobias, additional, Zorr, Andreas, additional, Glasspool, Ros, additional, Hudson, Emma, additional, Jones, Rachel, additional, Lafleur, Judith, additional, Marth, Christian, additional, Petru, Edgar, additional, Antill, Yoland, additional, Azer, Mary, additional, Baron-Hay, Sally, additional, Beale, Philip, additional, Begbie, Stephen, additional, Black, Allison, additional, Briscoe, Karen, additional, Dean, Andrew, additional, Goh, Jeffrey, additional, Harvey, Sandra, additional, Lee, Chee, additional, Matos, Marco, additional, Meniawy, Tarek, additional, Olesen, Inger, additional, Shannon, Catherine, additional, Vasey, Paul, additional, Abadie-Lacourtoisie, Sophie, additional, Arsene, Olivier, additional, Barthier, Sophie, additional, Becuwe-Roemer, Célia, additional, Berton-Rigaud, Dominique, additional, Cappiello-Bataller, Maria, additional, Catala, Stéphanie, additional, Del Piano, Francesco, additional, Deplanque, Gaël, additional, Despax, Raymond, additional, Dohollou, Nadine, additional, Garnier-Tixidré, Claire, additional, Grenier, Julien, additional, Guardiola, Emmanuel, additional, Hardy-Bessard, Anne-Claire, additional, Lefeuvre-Plesse, Claudia, additional, Leheurteur, Marianne, additional, Lesoin, Anne, additional, Levache, Charles-Briac, additional, Longo, Raffaele, additional, Lortholary, Alain, additional, Meunier, Jérôme, additional, Raban, Nadia, additional, Romano, Olivier, additional, Vannetzel, Jean-Michel, additional, and Zannetti, Alain, additional

Published
2020
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86. Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial

Author

Clamp, Andrew R, primary, James, Elizabeth C, additional, McNeish, Iain A, additional, Dean, Andrew, additional, Kim, Jae-Weon, additional, O'Donnell, Dearbhaile M, additional, Hook, Jane, additional, Coyle, Christopher, additional, Blagden, Sarah, additional, Brenton, James D, additional, Naik, Raj, additional, Perren, Tim, additional, Sundar, Sudha, additional, Cook, Adrian D, additional, Gopalakrishnan, Gosala S, additional, Gabra, Hani, additional, Lord, Rosemary, additional, Dark, Graham, additional, Earl, Helena M, additional, Hall, Marcia, additional, Banerjee, Susana, additional, Glasspool, Rosalind M, additional, Jones, Rachel, additional, Williams, Sarah, additional, Swart, Ann Marie, additional, Stenning, Sally, additional, Parmar, Mahesh, additional, Kaplan, Richard, additional, and Ledermann, Jonathan A, additional

Published
2019
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87. Abstract AP09: COPY-NUMBER SIGNATURES AND MUTATIONAL PROCESSES IN HIGH GRADE SEROUS OVARIAN CARCINOMA

Author

Macintyre, Geoff, primary, Goranova, Teodora E., additional, Silva, Dilrini De, additional, Ennis, Darren, additional, Piskorz, Anna M., additional, Eldridge, Matthew, additional, Sie, Daoud, additional, Lewsley, Liz-Anne, additional, Hanif, Aishah, additional, Wilson, Cheryl, additional, Dowson, Suzanne, additional, Glasspool, Rosalind M., additional, Lockley, Michelle, additional, Brockbank, Elly, additional, Montes, Ana, additional, Walther, Axel, additional, Sundar, Sudha, additional, Edmondson, Richard, additional, Hall, Geoff D., additional, Clamp, Andrew, additional, Gourley, Charlie, additional, Hall, Marcia, additional, Fotopoulou, Christina, additional, Gabra, Hani, additional, Paul, James, additional, Supernat, Anna, additional, Millan, David, additional, Hoyle, Aoisha, additional, Bryson, Gareth, additional, Nourse, Craig, additional, Mincarelli, Laura, additional, Sanchez, Luis Navarro, additional, Ylstra, Bauke, additional, Jimenez-Linan, Mercedes, additional, Moore, Luiza, additional, Hofmann, Oliver, additional, Markowetz, Florian, additional, McNeish, Iain A., additional, and Brenton, James D., additional

Published
2019
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88. Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: A systematic review and meta-analysis of individual patient data

Author

Cohen, Paul A., Powell, Aime, Böhm, Steffen, Gilks, C. Blake, Stewart, Colin J.R., Meniawy, Tarek M., Bulsara, Max, Avril, Stefanie, Brockbank, Eleanor C., Bosse, Tjalling, de Azevedo Focchi, Gustavo Rubino, Ganesan, Raji, Glasspool, Rosalind M., Howitt, Brooke E., Kim, Hyun-Soo, Lee, Jung-Yun, Le, Nhu D., Lockley, Michelle, Manchanda, Ranjit, Mandalia, Trupti, McCluggage, W. Glenn, McNeish, Iain, Midha, Divya, Srinivasan, Radhika, Tan, Yun Yi, van der Griend, Rachael, Yunokawa, Mayu, Zannoni, Gian F., Singh, Naveena, Aggarwal, Simi, Bronger, Holger, Brown, Elizabeth B., Buck, Martin, Bukhari, Syed A., Coghlan, Edwina, Cope, Nichola, de Almeida, Michelle Samora, De Kroon, Cornelius D., Dean, Andrew, Devlin, Michael-John, Ditzel, Helena M., Drecoll, Enken, Ebata, Takahiro, Fagotti, Anna, Faruqi, Asma, Feeney, Laura, Gupta, Kavita, Harley, Ian, Inzani, Frediano, Jeyarajah, Arjun R., Koay, M.H. Eleanor, Kroep, Judith R., Leung, Yee, Loft, Alice R., MaGee, Daniel, McKenna, Sarah, Millan, David, Millar, Joanne, Miller, Rowan, Mohan, Ganendra R., Mughal, Sohail, Nicolau, Sergio Mancini, Nevin, James, Oakley, Abigail S., Quigley, Mary, Rai, Bhavana, Rajwanshi, Arvind, Salfinger, Stuart G., Scambia, Giovanni, Scatchard, Kate, Schmalfeldt, Barbara, Simcock, Bryony, Singh, Priya, Strickland, Kyle C., Suri, Vainta, Syed, Sheeba, Sykes, Peter, Tamura, Kenji, Tan, Adeline, Tan, Jason, Thompson, Emily, Tinker, Anna V., Trevisan, Georgia, Uyeda, Maria Gabriela Baumgarten Kuster, Vaughan, Michelle M., Weichert, Wilko, Williams, Anthony, Williams, Sarah, Yoshida, Hiroshi, and Zorzato, Pier Carlo

Abstract

Objective:\ud There is a need to develop and validate biomarkers for treatment response and survival in tubo-ovarian high-grade serous carcinoma (HGSC). The chemotherapy response score (CRS) stratifies patients into complete/near-complete (CRS3), partial (CRS2), and no/minimal (CRS1) response after neoadjuvant chemotherapy (NACT). Our aim was to review current evidence to determine whether the CRS is prognostic in women with tubo-ovarian HGSC treated with NACT.\ud \ud Methods:\ud We established an international collaboration to conduct a systematic review and meta-analysis, pooling individual patient data from 16 sites in 11 countries. Patients had stage IIIC/IV HGSC, 3–4 NACT cycles and >6-months follow-up. Random effects models were used to derive combined odds ratios in the pooled population to investigate associations between CRS and progression free and overall survival (PFS and OS).\ud \ud Results:\ud 877 patients were included from published and unpublished studies. Median PFS and OS were 15 months (IQR 5–65) and 28 months (IQR 7–92) respectively. CRS3 was seen in 249 patients (28%). The pooled hazard ratios (HR) for PFS and OS for CRS3 versus CRS1/CRS2 were 0·55 (95% CI, 0·45–0·66; P

Published
2019

89. Progression free survival as a surrogate endpoint for overall survival in first-line therapy of advanced ovarian cancer: A Gynecologic Cancer InterGroup (GCIG) individual patient-level meta-analysis

Author

Glasspool, Rosalind, Lewsley, Liz-Anne, Daniele, Gennaro, Cook, Adrian David, Yanaihara, Nozomu, Tinker, Anna, Kristensen, Gunnar, Ottevanger, Petronella, Aravantinos, Gerasimos, Boere, Ingrid A., Fruscio, Robert, Reyners, Anna K. L., Pujade-Lauraine, Eric, Harkin, Andrea, Pignata, Sandro, Kagimura, Tatsuo, Welch, Stephen, Eleni, Karamouza, Kaye, Stan, Perren, Timothy, Banerjee, Susana N., Paoletti, Xavier, Targeted Gynaecologic Oncology (TARGON), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Published
2018

90. ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease

Author

Selçukbiricik, Fatih, Colombo, Nicoletta; Sessa, Christiana; du Bois, Andreas; Ledermann, Jonathan; McCluggage, W. Glenn; McNeish, Iain; Morice, Phillippe; Pignata, Sando; Ray-Coquard, Isabelle; Vergote, Ignace; Baert, Thais; Belaroussi, I.; Dashora, Abhissek; Olbrecht, Siel; Planchamp, Francois; Querleu, Denis; Banerjee, S.; Blecharz, Pawel; Bruchim, Ilan; Cibula, Donald; Concin, Nicole; Davidson, Ben; Devouassoux-Shisheboran, Mojgan; Ferrero, Annamaria; Glasspool, Rosalind; Gonzalez-Martin, Antonio; Heinzelmann-Schwarz, Viola; Joly, Florence; Kim, J. W.; Kridelka, Frederic; Lorusso, Domenika; Mahner, Sven; Mikami, Mikio; Mirza, Mansoor Raza; Nicum, Shibani; O'Donnell, Dearbhaile M.; Pautier, Patricia; Rodolakis, Alexander; Sehouli, Jalid; Singh, N.; Tan, David Shao Peng; Timmerman, D.; Tognon, Germana; van der Velden, Jacobus; Witteveen, Petronella O.; Zeimet, Alain G., Koç University Hospital, Selçukbiricik, Fatih, Colombo, Nicoletta; Sessa, Christiana; du Bois, Andreas; Ledermann, Jonathan; McCluggage, W. Glenn; McNeish, Iain; Morice, Phillippe; Pignata, Sando; Ray-Coquard, Isabelle; Vergote, Ignace; Baert, Thais; Belaroussi, I.; Dashora, Abhissek; Olbrecht, Siel; Planchamp, Francois; Querleu, Denis; Banerjee, S.; Blecharz, Pawel; Bruchim, Ilan; Cibula, Donald; Concin, Nicole; Davidson, Ben; Devouassoux-Shisheboran, Mojgan; Ferrero, Annamaria; Glasspool, Rosalind; Gonzalez-Martin, Antonio; Heinzelmann-Schwarz, Viola; Joly, Florence; Kim, J. W.; Kridelka, Frederic; Lorusso, Domenika; Mahner, Sven; Mikami, Mikio; Mirza, Mansoor Raza; Nicum, Shibani; O'Donnell, Dearbhaile M.; Pautier, Patricia; Rodolakis, Alexander; Sehouli, Jalid; Singh, N.; Tan, David Shao Peng; Timmerman, D.; Tognon, Germana; van der Velden, Jacobus; Witteveen, Petronella O.; Zeimet, Alain G., and Koç University Hospital

Abstract

The development of guidelines recommendations is one of the core activities of the European Society for Medical Oncology (ESMO) and European Society of Gynaecologial Oncology (ESGO), as part of the mission of both societies to improve the quality of care for patients with cancer across Europe. ESMO and ESGO jointly developed clinically relevant and evidence-based recommendations in several selected areas in order to improve the quality of care for women with ovarian cancer. The ESMO-ESGO consensus conference on ovarian cancer was held on April 12-14, 2018 in Milan, Italy, and comprised a multidisciplinary panel of 40 leading experts in the management of ovarian cancer. Before the conference, the expert panel worked on five clinically relevant questions regarding ovarian cancer relating to each of the following four areas: pathology and molecular biology, early-stage and borderline tumours, advanced stage disease and recurrent disease. Relevant scientific literature, as identified using a systematic search, was reviewed in advance. During the consensus conference, the panel developed recommendations for each specific question and a consensus was reached. The recommendations presented here are thus based on the best available evidence and expert agreement. This article presents the recommendations of this ESMO-ESGO consensus conference, together with a summary of evidence supporting each recommendation., ESMO and ESGO funds

Published
2019

92. Molecular and clinical predictors of improvement in progression‐free survival with maintenance PARP inhibitor therapy in women with platinum‐sensitive, recurrent ovarian cancer: A meta‐analysis.

Author

Lee, Chee Khoon, Friedlander, Michael L., Tjokrowidjaja, Angelina, Ledermann, Jonathan A., Coleman, Robert L., Mirza, Mansoor R., Matulonis, Ursula A., Pujade‐Lauraine, Eric, Bloomfield, Ralph, Goble, Sandra, Wang, Ping, Glasspool, Rosalind M., and Scott, Clare L.

Subjects
OVARIAN cancer, PROGRESSION-free survival, GENETIC mutation, FORECASTING, POLY(ADP-ribose) polymerase, BRCA genes, POLYMERASES
Abstract

BACKGROUND: The authors performed a meta‐analysis to better quantify the benefit of maintenance poly(ADP‐ribose) polymerase inhibitor (PARPi) therapy to inform practice in platinum‐sensitive, recurrent, high‐grade ovarian cancer for patient subsets with the following characteristics: germline BRCA mutation (gBRCAm), somatic BRCA mutation (sBRCAm), wild‐type BRCA but homologous recombinant‐deficient (HRD), homologous recombinant‐proficient (HRP), and baseline clinical prognostic characteristics. METHODS: Randomized trials comparing a PARPi versus placebo as maintenance treatment were identified from electronic databases. Treatment estimates of progression‐free survival were pooled across trials using the inverse variance weighted method. RESULTS: Four trials included 972 patients who received a PARPi (olaparib, 31%; niraparib, 35%; or rucaparib, 34%) and 530 patients who received placebo. For patients who had germline BRCA1 mutation (gBRCAm1) (N = 471), the hazard ratio (HR) was 0.29 (95% CI, 0.23‐0.37); for those who had germline BRCA2 mutation (gBRCAm2) (N = 236), the HR was 0.26 (95% CI, 0.17‐0.39); and, for those who had sBRCAm (N = 123), the HR was 0.22 (95% CI, 0.12‐0.41). The treatment effect was similar between the gBRCAm and sBRCAm subsets (P =.48). In patients who had wild‐type BRCA HRD tumors (excluding sBRCAm; N = 309), the HR was 0.41 (95% CI, 0.31‐0.56); and, in those who had wild‐type BRCA HRP tumors (N = 346), the HR was 0.64 (95% CI, 0.49‐0.83). The relative treatment effect was greater for the BRCAm versus HRD (P =.03), BRCAm versus HRP (P <.00001), and HRD versus HRP (P <.00001) subsets. There was no difference in benefit based on age, response after recent chemotherapy, and prior bevacizumab. CONCLUSIONS: In platinum‐sensitive, recurrent, high‐grade ovarian cancer, maintenance PARPi improves progression‐free survival for all patient subsets. PARPi therapy has a similar magnitude of benefit for sBRCAm and gBRCAm. Although patients with BRCAm derive the greatest benefit, the absence of a BRCAm or HRD could not be used to exclude patients from maintenance PARPi therapy. BRCA mutation status is able to predict for the magnitude of PARP inhibitor benefit in platinum‐sensitive recurrent high‐grade ovarian tumor. However, the absence of a BRCA mutation or homologous recombinant deficiency in high‐grade ovarian tumor cannot be used to exclude patients from such therapy. [ABSTRACT FROM AUTHOR]

Published
2021
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93. ENGOT-OV44/FIRST study: A randomized, double-blind, adaptive, phase III study of platinum-based therapy with dostarlimab (TSR-042) + niraparib versus standard-of-care (SOC) platinum-based therapy as first-line treatment of stage 3/4 non-mucinous epithelial ovarian cancer (OC).

Author

Hardy-Bessard, Anne-Claire, primary, Moore, Kathleen N., additional, Mirza, Mansoor Raza, additional, Asselain, Bernard, additional, Redondo, Andres, additional, Pfisterer, Jacobus, additional, Pignata, Sandro, additional, Provencher, Diane M., additional, Cibula, David, additional, Reyners, Anna K.L., additional, Bodnar, Lubomir, additional, Glasspool, Rosalind Margaret, additional, Papadimitriou, Christos A., additional, Eitan, Rami, additional, Han, Sileny, additional, Duska, Linda R., additional, Rimel, Bj, additional, Hazard, Sebastien, additional, Chen, Jian, additional, and Pujade-Lauraine, Eric, additional

Published
2019
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94. Safety and utility of image-guided research\ud biopsies in relapsed high-grade serous\ud ovarian carcinoma—experience of the\ud BriTROC consortium

Author

Goranova, Teodora, Ennis, Darren, Piskorz, Anna M., Macintyre, Geoff, Lewsley, Liz-Anne, Stobo, Jon, Wilson, Cheryl, Kay, David, Glasspool, Rosalind M., Lockley, Michelle, Brockbank, Eleanor, Montes, Ana, Walther, Axel, Sundar, Sudha, Edmondson, Richard, Hall, Geoff D., Clamp, Andrew, Gourley, Charles, Hall, Marcia, Fotopoulou, Christina, Gabra, Hani, Freeman, Susan, Moore, Luisa, Jimenez-Linan, Mercedes, Paul, Jim, Brenton, James D., and McNeish, Iain A.

Abstract

Background: Investigating tumour evolution and acquired chemotherapy resistance requires analysis of sequential tumour\ud material. We describe the feasibility of obtaining research biopsies in women with relapsed ovarian high-grade serous carcinoma\ud (HGSC).\ud Methods: Women with relapsed ovarian HGSC underwent either image-guided biopsy or intra-operative biopsy during\ud secondary debulking, and samples were fixed in methanol-based fixative. Tagged-amplicon sequencing was performed on biopsy\ud DNA.\ud Results: We screened 519 patients in order to enrol 220. Two hundred and two patients underwent successful biopsy, 118 of which\ud were image-guided. There were 22 study-related adverse events (AE) in the image-guided biopsies, all grades 1 and 2; pain was\ud the commonest AE. There were pre-specified significant AE in 3/118 biopsies (2.5%). 87% biopsies were fit-for-purpose for\ud genomic analyses. Median DNA yield was 2.87 mg, and was higher in biopsies utilising 14 G or 16 G needles compared to 18 G.\ud TP53 mutations were identified in 94.4% patients.\ud Conclusions: Obtaining tumour biopsies for research in relapsed HGSC is safe and feasible. Adverse events are rare. The large\ud majority of biopsies yield sufficient DNA for genomic analyses—we recommend use of larger gauge needles and methanol\ud fixation for such biopsies, as DNA yields are higher but with no increase in AEs.

Published
2017

95. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Author

Phelan, Catherine M. Kuchenbaecker, Karoline B. Tyrer, Jonathan P. Kar, Siddhartha P. Lawrenson, Kate Winham, Stacey J. and Dennis, Joe Pirie, Ailith Riggan, Marjorie J. Chornokur, Ganna Earp, Madalene A. Lyra, Jr., Paulo C. Lee, Janet M. and Coetzee, Simon Beesley, Jonathan McGuffog, Lesley Soucy, Penny Dicks, Ed Lee, Andrew Barrowdale, Daniel and Lecarpentier, Julie Leslie, Goska Aalfs, Cora M. Aben, Katja K. H. Adams, Marcia Adlard, Julian Andrulis, Irene L. and Anton-Culver, Hoda Antonenkova, Natalia Aravantinos, Gerasimos and Arnold, Norbert Arun, Banu K. Arver, Brita Azzollini, Jacopo Balmana, Judith Banerjee, Susana N. Barjhoux, Laure and Barkardottir, Rosa B. Bean, Yukie Beckmann, Matthias W. and Beeghly-Fadiel, Alicia Benitez, Javier Bermisheva, Marina and Bernardini, Marcus Q. Birrer, Michael J. Bjorge, Line Black, Amanda Blankstein, Kenneth Blok, Marinus J. Bodelon, Clara and Bogdanova, Natalia Bojesen, Anders Bonanni, Bernardo and Borg, Ake Bradbury, Angela R. Brenton, James D. Brewer, Carole Brinton, Louise Broberg, Per Brooks-Wilson, Angela and Bruinsma, Fiona Brunet, Joan Buecher, Bruno Butzow, Ralf and Buys, Saundra S. Caldes, Trinidad Caligo, Maria A. and Campbell, Ian Cannioto, Rikki Carney, Michael E. Cescon, Terence Chan, Salina B. Chang-Claude, Jenny Chanock, Stephen and Chen, Xiao Qing Chiew, Yoke-Eng Chiquette, Jocelyne and Chung, Wendy K. Claes, Kathleen B. M. Conner, Thomas Cook, Linda S. Cook, Jackie Cramer, Daniel W. Cunningham, Julie M. and D'Aloisio, Aimee A. Daly, Mary B. Damiola, Francesca and Damirovna, Sakaeva Dina Dansonka-Mieszkowska, Agnieszka Dao, Fanny Davidson, Rosemarie DeFazio, Anna Delnatte, Capucine and Doheny, Kimberly F. Diez, Orland Ding, Yuan Chun and Doherty, Jennifer Anne Domchek, Susan M. Dorfling, Cecilia M. and Dork, Thilo Dossus, Laure Duran, Mercedes Durst, Matthias Dworniczak, Bernd Eccles, Diana Edwards, Todd and Eeles, Ros Eilber, Ursula Ejlertsen, Bent Ekici, Arif B. and Ellis, Steve Elvira, Mingajeva Eng, Kevin H. Engel, Christoph Evans, D. Gareth Fasching, Peter A. Ferguson, Sarah Ferrer, Sandra Fert Flanagan, James M. Fogarty, Zachary C. Fortner, Renee T. Fostira, Florentia Foulkes, William D. Fountzilas, George Fridley, Brooke L. Friebel, Tara M. Friedman, Eitan Frost, Debra Ganz, Patricia A. and Garber, Judy Garcia, Maria J. Garcia-Barberan, Vanesa and Gehrig, Andrea Gentry-Maharaj, Aleksandra Gerdes, Anne-Marie and Giles, Graham G. Glasspool, Rosalind Glendon, Gord Godwin, Andrew K. Goldgar, David E. Goranova, Teodora Gore, Martin and Greene, Mark H. Gronwald, Jacek Gruber, Stephen Hahnen, Eric Haiman, Christopher A. Hakansson, Niclas Hamann, Ute and Hansen, Thomas V. O. Harrington, Patricia A. Harris, Holly R. Hauke, Jan Hein, Alexander Henderson, Alex and Hildebrandt, Michelle A. T. Hillemanns, Peter Hodgson, Shirley and Hogdall, Claus K. Hogdall, Estrid Hogervorst, Frans B. L. and Holland, Helene Hooning, Maartje J. Hosking, Karen and Huang, Ruea-Yea Hulick, Peter J. Hung, Jillian Hunter, David J. Huntsman, David G. Huzarski, Tomasz Imyanitov, Evgeny N. and Isaacs, Claudine Iversen, Edwin S. Izatt, Louise and Izquierdo, Angel Jakubowska, Anna James, Paul Janavicius, Ramunas Jernetz, Mats Jensen, Allan Jensen, Uffe Birk and John, Esther M. Johnatty, Sharon Jones, Michael E. Kannisto, Paivi Karlan, Beth Y. Karnezis, Anthony Kast, Karin and Kennedy, Catherine J. Khusnutdinova, Elza Kiemeney, Lambertus A. and Kiiski, Johanna I. Kim, Sung-Won Kjaer, Susanne K. and Kobel, Martin Kopperud, Reidun K. Kruse, Torben A. and Kupryjanczyk, Jolanta Kwong, Ava Laitman, Yael Lambrechts, Diether Larranaga, Nerea Larson, Melissa C. Lazaro, Conxi and Le, Nhu D. Le Marchand, Loic Lee, Jong Won Lele, Shashikant B. Leminen, Arto Leroux, Dominique Lester, Jenny and Lesueur, Fabienne Levine, Douglas A. Liang, Dong and Liebrich, Clemens Lilyquist, Jenna Lipworth, Loren and Lissowska, Jolanta Lu, Karen H. Lubinski, Jan Luccarini, Craig Lundvall, Lene Mai, Phuong L. Mendoza-Fandino, Gustavo and Manoukian, Siranoush Massuger, Leon F. A. G. May, Taymaa and Mazoyer, Sylvie McAlpine, Jessica N. McGuire, Valerie and McLaughlin, John R. McNeish, Iain Meijers-Heijboer, Hanne and Meindl, Alfons Menon, Usha Mensenkamp, Arjen R. Merritt, Melissa A. Milne, Roger L. Mitchell, Gillian Modugno, Francesmary Moes-Sosnowska, Joanna Moffitt, Melissa and Montagna, Marco Moysich, Kirsten B. Mulligan, Anna Marie and Musinsky, Jacob Nathanson, Katherine L. Nedergaard, Lotte and Ness, Roberta B. Neuhausen, Susan L. Nevanlinna, Heli and Niederacher, Dieter Nussbaum, Robert L. Odunsi, Kunle Olah, Edith Olopade, Olufunmilayo I. Olsson, Hakan Olswold, Curtis and O'Malley, David M. Ong, Kai-ren Onland-Moret, N. Charlotte and Orr, Nicholas Orsulic, Sandra Osorio, Ana Palli, Domenico Papi, Laura Park-Simon, Tjoung-Won Paul, James and Pearce, Celeste L. Pedersen, Inge Sokilde Peeters, Petra H. M. and Peissel, Bernard Peixoto, Ana Pejovic, Tanja Pelttari, Liisa M. Permuth, Jennifer B. Peterlongo, Paolo Pezzani, Lidia Pfeiler, Georg Phillips, Kelly-Anne Piedmonte, Marion and Pike, Malcolm C. Piskorz, Anna M. Poblete, Samantha R. and Pocza, Timea Poole, Elizabeth M. Poppe, Bruce Porteous, Mary E. Prieur, Fabienne Prokofyeva, Darya Pugh, Elizabeth and Pujana, Miquel Angel Pujol, Pascal Radice, Paolo Rantala, Johanna Rappaport-Fuerhauser, Christine Rennert, Gad Rhiem, Kerstin Rice, Patricia Richardson, Andrea Robson, Mark and Rodriguez, Gustavo C. Rodriguez-Antona, Cristina Romm, Jane and Rookus, Matti A. Rossing, Mary Anne Rothstein, Joseph H. and Rudolph, Anja Runnebaum, Ingo B. Salvesen, Helga B. Sandler, Dale P. Schoemaker, Minouk J. Senter, Leigha Setiawan, V. Wendy Severi, Gianluca Sharma, Priyanka Shelford, Tameka and Siddiqui, Nadeem Side, Lucy E. Sieh, Weiva Singer, Christian F. Sobol, Hagay Song, Honglin Southey, Melissa C. and Spurdle, Amanda B. Stadler, Zsofia Steinemann, Doris and Stoppa-Lyonnet, Dominique Sucheston-Campbell, Lara E. and Sukiennicki, Grzegorz Sutphen, Rebecca Sutter, Christian and Swerdlow, Anthony J. Szabo, Csilla I. Szafron, Lukasz Tan, Yen Y. Taylor, Jack A. Tea, Muy-Kheng Teixeira, Manuel R. and Teo, Soo-Hwang Terry, Kathryn L. Thompson, Pamela J. and Thomsen, Liv Cecilie Vestrheim Thull, Darcy L. Tihomirova, Laima and Tinker, Anna V. Tischkowitz, Marc Tognazzo, Silvia and Toland, Amanda Ewart Tone, Alicia Trabert, Britton Travis, Ruth C. Trichopoulou, Antonia Tung, Nadine Tworoger, Shelley S. Van Altena, Anne M. Van den Berg, David van der Hout, Annemarie H. van der Luijt, Rob B. Van Heetvelde, Mattias and Van Nieuwenhuysen, Els Van Rensburg, Elizabeth J. and Vanderstichele, Adriaan Varon-Mateeva, Raymonda Vega, Ana and Edwards, Digna Velez Vergote, Ignace Vierkant, Robert A. and Vijai, Joseph Vratimos, Athanassios Walker, Lisa Walsh, Christine Wand, Dorothea Wang-Gohrke, Shan Wappenschmidt, Barbara Webb, Penelope M. Weinberg, Clarice R. Weitzel, Jeffrey N. Wentzensen, Nicolas Whittemore, Alice S. Wijnen, Juul T. Wilkens, Lynne R. Wolk, Alicja Woo, Michelle Wu, Xifeng Wu, Anna H. Yang, Hannah Yannoukakos, Drakoulis and Ziogas, Argyrios Zorn, Kristin K. Narod, Steven A. Easton, Douglas F. Amos, Christopher I. Schildkraut, Joellen M. and Ramus, Susan J. Ottini, Laura Goodman, Marc T. Park-, Sue K. and Kelemen, Linda E. Risch, Harvey A. Thomassen, Mads and Offit, Kenneth Simard, Jacques Schmutzler, Rita Katharina and Hazelett, Dennis Monteiro, Alvaro N. Couch, Fergus J. and Berchuck, Andrew Chenevix-Trench, Georgia Goode, Ellen L. and Sellers, Thomas A. Gayther, Simon A. Antoniou, Antonis C. and Pharoah, Paul D. P. AOCS Study Grp EMEMBRACE Study GEMO Study Collaborators HEBON Study KConFab Investigators OPAL Study Grp

Subjects
endocrine system diseases, female genital diseases and pregnancy complications
Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

Published
2017

96. METRO-BIBF: Phase II, randomised, placebo controlled, multicentre, trial of low dose (metronomic) cyclophosphamide (MCy) with or without nintedanib in relapsed ovarian cancer (ROC).

Author

Hall, Marcia, primary, Debhi, Hakim-Moulay, additional, Nicum, Shibani, additional, Lord, Rosemary, additional, Banerjee, Susana N., additional, Clamp, Andrew R., additional, Lilleywhite, Rachel, additional, Glasspool, Rosalind Margaret, additional, Feeney, Amanda, additional, Hackshaw, Allan, additional, and Ledermann, Jonathan A., additional

Published
2018
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97. Pathological Chemotherapy Response Score Predicts Survival in Patients with Advanced Ovarian Cancer Receiving Neoadjuvant Chemotherapy: Systematic Review and Meta-Analysis of Individual Patient Data

Author

Cohen, Paul, primary, Powell, Aime, additional, Böhm, Steffen, additional, Gilks, C. Blake, additional, Stewart, Colin J.R., additional, Meniawy, Tarek M., additional, Bulsara, Max, additional, Avril, Stefanie, additional, Brockbank, Elly C., additional, Bosse, Tjalling, additional, Focchi, Gustavo Rubino de Azevedo, additional, Ganesan, Raji, additional, Glasspool, Rosalind M., additional, Howitt, Brooke E., additional, Kim, Hyun-Soo, additional, Lee, Jung-Yun, additional, Lee, Nhu D., additional, Lockley, Michelle, additional, Manchanda, Ranchit, additional, Mandalia, Trupti, additional, McCluggage, W. Glenn, additional, McNeish, Iain, additional, Midha, Divya, additional, Srinivasan, Radhika, additional, Tan, Yun Yi, additional, van der Griend, Rachael, additional, Yunokawa, Mayu, additional, Zannoni, Gian F., additional, Network, HGSC CRS Collaborative, additional, and Singh, Naveena, additional

Published
2018
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98. The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma

Author

Cooke, Susanna L., primary, Ennis, Darren, additional, Evers, Lisa, additional, Dowson, Suzanne, additional, Chan, Mei Yen, additional, Paul, James, additional, Hirschowitz, Lynn, additional, Glasspool, Rosalind M., additional, Singh, Naveena, additional, Bell, Sarah, additional, Day, Elizabeth, additional, Kochman, Agata, additional, Wilkinson, Nafisa, additional, Beer, Philip, additional, Martin, Sancha, additional, Millan, David, additional, Biankin, Andrew V., additional, and McNeish, Iain A., additional

Published
2017
Full Text
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99. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Author

Phelan, Catherine M., Kuchenbaecker, Karoline B., Tyrer, Jonathan P., Kar, Siddhartha P., Lawrenson, Kate, Winham, Stacey J., Dennis, Joe, Pirie, Ailith, Riggan, Marjorie J., Chornokur, Ganna, Earp, Madalene A., Lyra, Paulo C., Jr., Lee, Janet M., Coetzee, Simon, Beesley, Jonathan, McGuffog, Lesley, Soucy, Penny, Dicks, Ed, Lee, Andrew, Barrowdale, Daniel, Lecarpentier, Julie, Leslie, Goska, Aalfs, Cora M., Aben, Katja K. H., Adams, Marcia, Adlard, Julian, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia, Aravantinos, Gerasimos, Arnold, Norbert, Arun, Banu K., Arver, Brita, Azzollini, Jacopo, Balmana, Judith, Banerjee, Susana N., Barjhoux, Laure, Barkardottir, Rosa B., Bean, Yukie, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Birrer, Michael J., Bjorge, Line, Black, Amanda, Blankstein, Kenneth, Blok, Marinus J., Bodelon, Clara, Bogdanova, Natalia, Bojesen, Anders, Bonanni, Bernardo, Borg, Ake, Bradbury, Angela R., Brenton, James D., Brewer, Carole, Brinton, Louise, Broberg, Per, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Buecher, Bruno, Butzow, Ralf, Buys, Saundra S., Caldes, Trinidad, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Carney, Michael E., Cescon, Terence, Chan, Salina B., Chang-Claude, Jenny, Chanock, Stephen, Chen, Xiao Qing, Chiew, Yoke-Eng, Chiquette, Jocelyne, Chung, Wendy K., Claes, Kathleen B. M., Conner, Thomas, Cook, Linda S., Cook, Jackie, Cramer, Daniel W., Cunningham, Julie M., D'Aloisio, Aimee A., Daly, Mary B., Damiola, Francesca, Damirovna, Sakaeva Dina, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Davidson, Rosemarie, DeFazio, Anna, Delnatte, Capucine, Doheny, Kimberly F., Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer Anne, Domchek, Susan M., Dorfling, Cecilia M., Dork, Thilo, Dossus, Laure, Duran, Mercedes, Durst, Matthias, Dworniczak, Bernd, Eccles, Diana, Edwards, Todd, Eeles, Ros, Eilber, Ursula, Ejlertsen, Bent, Ekici, Arif B., Ellis, Steve, Elvira, Mingajeva, Eng, Kevin H., Engel, Christoph, Evans, D. Gareth, Fasching, Peter A., Ferguson, Sarah, Ferrer, Sandra Fert, Flanagan, James M., Fogarty, Zachary C., Fortner, Renee T., Fostira, Florentia, Foulkes, William D., Fountzilas, George, Fridley, Brooke L., Friebel, Tara M., Friedman, Eitan, Frost, Debra, Ganz, Patricia A., Garber, Judy, Garcia, Maria J., Garcia-Barberan, Vanesa, Gehrig, Andrea, Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Goranova, Teodora, Gore, Martin, Greene, Mark H., Gronwald, Jacek, Gruber, Stephen, Hahnen, Eric, Haiman, Christopher A., Hakansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harrington, Patricia A., Harris, Holly R., Hauke, Jan, Hein, Alexander, Henderson, Alex, Hildebrandt, Michelle A. T., Hillemanns, Peter, Hodgson, Shirley, Hogdall, Claus K., Hogdall, Estrid, Hogervorst, Frans B. L., Holland, Helene, Hooning, Maartje J., Hosking, Karen, Huang, Ruea-Yea, Hulick, Peter J., Hung, Jillian, Hunter, David J., Huntsman, David G., Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Iversen, Edwin S., Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jernetz, Mats, Jensen, Allan, Jensen, Uffe Birk, John, Esther M., Johnatty, Sharon, Jones, Michael E., Kannisto, Paivi, Karlan, Beth Y., Karnezis, Anthony, Kast, Karin, Kennedy, Catherine J., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kiiski, Johanna I., Kim, Sung-Won, Kjaer, Susanne K., Kobel, Martin, Kopperud, Reidun K., Kruse, Torben A., Kupryjanczyk, Jolanta, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Larranaga, Nerea, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Le Marchand, Loic, Lee, Jong Won, Lele, Shashikant B., Leminen, Arto, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Liang, Dong, Liebrich, Clemens, Lilyquist, Jenna, Lipworth, Loren, Lissowska, Jolanta, Lu, Karen H., Lubinski, Jan, Luccarini, Craig, Lundvall, Lene, Mai, Phuong L., Mendoza-Fandino, Gustavo, Manoukian, Siranoush, Massuger, Leon F. A. G., May, Taymaa, Mazoyer, Sylvie, McAlpine, Jessica N., McGuire, Valerie, McLaughlin, John R., McNeish, Iain, Meijers-Heijboer, Hanne, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R., Merritt, Melissa A., Milne, Roger L., Mitchell, Gillian, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moffitt, Melissa, Montagna, Marco, Moysich, Kirsten B., Mulligan, Anna Marie, Musinsky, Jacob, Nathanson, Katherine L., Nedergaard, Lotte, Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L., Odunsi, Kunle, Olah, Edith, Olopade, Olufunmilayo I., Olsson, Hakan, Olswold, Curtis, O'Malley, David M., Ong, Kai-ren, Onland-Moret, N. Charlotte, Orr, Nicholas, Orsulic, Sandra, Osorio, Ana, Palli, Domenico, Papi, Laura, Park-Simon, Tjoung-Won, Paul, James, Pearce, Celeste L., Pedersen, Inge Sokilde, Peeters, Petra H. M., Peissel, Bernard, Peixoto, Ana, Pejovic, Tanja, Pelttari, Liisa M., Permuth, Jennifer B., Peterlongo, Paolo, Pezzani, Lidia, Pfeiler, Georg, Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C., Piskorz, Anna M., Poblete, Samantha R., Pocza, Timea, Poole, Elizabeth M., Poppe, Bruce, Porteous, Mary E., Prieur, Fabienne, Prokofyeva, Darya, Pugh, Elizabeth, Pujana, Miquel Angel, Pujol, Pascal, Radice, Paolo, Rantala, Johanna, Rappaport-Fuerhauser, Christine, Rennert, Gad, Rhiem, Kerstin, Rice, Patricia, Richardson, Andrea, Robson, Mark, Rodriguez, Gustavo C., Rodriguez-Antona, Cristina, Romm, Jane, Rookus, Matti A., Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Salvesen, Helga B., Sandler, Dale P., Schoemaker, Minouk J., Senter, Leigha, Setiawan, V. Wendy, Severi, Gianluca, Sharma, Priyanka, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E., Sieh, Weiva, Singer, Christian F., Sobol, Hagay, Song, Honglin, Southey, Melissa C., Spurdle, Amanda B., Stadler, Zsofia, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sucheston-Campbell, Lara E., Sukiennicki, Grzegorz, Sutphen, Rebecca, Sutter, Christian, Swerdlow, Anthony J., Szabo, Csilla I., Szafron, Lukasz, Tan, Yen Y., Taylor, Jack A., Tea, Muy-Kheng, Teixeira, Manuel R., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tihomirova, Laima, Tinker, Anna V., Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda Ewart, Tone, Alicia, Trabert, Britton, Travis, Ruth C., Trichopoulou, Antonia, Tung, Nadine, Tworoger, Shelley S., Van Altena, Anne M., Van den Berg, David, van der Hout, Annemarie H., van der Luijt, Rob B., Van Heetvelde, Mattias, Van Nieuwenhuysen, Els, Van Rensburg, Elizabeth J., Vanderstichele, Adriaan, Varon-Mateeva, Raymonda, Vega, Ana, Edwards, Digna Velez, Vergote, Ignace, Vierkant, Robert A., Vijai, Joseph, Vratimos, Athanassios, Walker, Lisa, Walsh, Christine, Wand, Dorothea, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittemore, Alice S., Wijnen, Juul T., Wilkens, Lynne R., Wolk, Alicja, Woo, Michelle, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Yannoukakos, Drakoulis, Ziogas, Argyrios, Zorn, Kristin K., Narod, Steven A., Easton, Douglas F., Amos, Christopher I., Schildkraut, Joellen M., Ramus, Susan J., Ottini, Laura, Goodman, Marc T., Park-, Sue K., Kelemen, Linda E., Risch, Harvey A., Thomassen, Mads, Offit, Kenneth, Simard, Jacques, Schmutzler, Rita Katharina, Hazelett, Dennis, Monteiro, Alvaro N., Couch, Fergus J., Berchuck, Andrew, Chenevix-Trench, Georgia, Goode, Ellen L., Sellers, Thomas A., Gayther, Simon A., Antoniou, Antonis C., Pharoah, Paul D. P., Phelan, Catherine M., Kuchenbaecker, Karoline B., Tyrer, Jonathan P., Kar, Siddhartha P., Lawrenson, Kate, Winham, Stacey J., Dennis, Joe, Pirie, Ailith, Riggan, Marjorie J., Chornokur, Ganna, Earp, Madalene A., Lyra, Paulo C., Jr., Lee, Janet M., Coetzee, Simon, Beesley, Jonathan, McGuffog, Lesley, Soucy, Penny, Dicks, Ed, Lee, Andrew, Barrowdale, Daniel, Lecarpentier, Julie, Leslie, Goska, Aalfs, Cora M., Aben, Katja K. H., Adams, Marcia, Adlard, Julian, Andrulis, Irene L., Anton-Culver, Hoda, Antonenkova, Natalia, Aravantinos, Gerasimos, Arnold, Norbert, Arun, Banu K., Arver, Brita, Azzollini, Jacopo, Balmana, Judith, Banerjee, Susana N., Barjhoux, Laure, Barkardottir, Rosa B., Bean, Yukie, Beckmann, Matthias W., Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Bernardini, Marcus Q., Birrer, Michael J., Bjorge, Line, Black, Amanda, Blankstein, Kenneth, Blok, Marinus J., Bodelon, Clara, Bogdanova, Natalia, Bojesen, Anders, Bonanni, Bernardo, Borg, Ake, Bradbury, Angela R., Brenton, James D., Brewer, Carole, Brinton, Louise, Broberg, Per, Brooks-Wilson, Angela, Bruinsma, Fiona, Brunet, Joan, Buecher, Bruno, Butzow, Ralf, Buys, Saundra S., Caldes, Trinidad, Caligo, Maria A., Campbell, Ian, Cannioto, Rikki, Carney, Michael E., Cescon, Terence, Chan, Salina B., Chang-Claude, Jenny, Chanock, Stephen, Chen, Xiao Qing, Chiew, Yoke-Eng, Chiquette, Jocelyne, Chung, Wendy K., Claes, Kathleen B. M., Conner, Thomas, Cook, Linda S., Cook, Jackie, Cramer, Daniel W., Cunningham, Julie M., D'Aloisio, Aimee A., Daly, Mary B., Damiola, Francesca, Damirovna, Sakaeva Dina, Dansonka-Mieszkowska, Agnieszka, Dao, Fanny, Davidson, Rosemarie, DeFazio, Anna, Delnatte, Capucine, Doheny, Kimberly F., Diez, Orland, Ding, Yuan Chun, Doherty, Jennifer Anne, Domchek, Susan M., Dorfling, Cecilia M., Dork, Thilo, Dossus, Laure, Duran, Mercedes, Durst, Matthias, Dworniczak, Bernd, Eccles, Diana, Edwards, Todd, Eeles, Ros, Eilber, Ursula, Ejlertsen, Bent, Ekici, Arif B., Ellis, Steve, Elvira, Mingajeva, Eng, Kevin H., Engel, Christoph, Evans, D. Gareth, Fasching, Peter A., Ferguson, Sarah, Ferrer, Sandra Fert, Flanagan, James M., Fogarty, Zachary C., Fortner, Renee T., Fostira, Florentia, Foulkes, William D., Fountzilas, George, Fridley, Brooke L., Friebel, Tara M., Friedman, Eitan, Frost, Debra, Ganz, Patricia A., Garber, Judy, Garcia, Maria J., Garcia-Barberan, Vanesa, Gehrig, Andrea, Gentry-Maharaj, Aleksandra, Gerdes, Anne-Marie, Giles, Graham G., Glasspool, Rosalind, Glendon, Gord, Godwin, Andrew K., Goldgar, David E., Goranova, Teodora, Gore, Martin, Greene, Mark H., Gronwald, Jacek, Gruber, Stephen, Hahnen, Eric, Haiman, Christopher A., Hakansson, Niclas, Hamann, Ute, Hansen, Thomas V. O., Harrington, Patricia A., Harris, Holly R., Hauke, Jan, Hein, Alexander, Henderson, Alex, Hildebrandt, Michelle A. T., Hillemanns, Peter, Hodgson, Shirley, Hogdall, Claus K., Hogdall, Estrid, Hogervorst, Frans B. L., Holland, Helene, Hooning, Maartje J., Hosking, Karen, Huang, Ruea-Yea, Hulick, Peter J., Hung, Jillian, Hunter, David J., Huntsman, David G., Huzarski, Tomasz, Imyanitov, Evgeny N., Isaacs, Claudine, Iversen, Edwin S., Izatt, Louise, Izquierdo, Angel, Jakubowska, Anna, James, Paul, Janavicius, Ramunas, Jernetz, Mats, Jensen, Allan, Jensen, Uffe Birk, John, Esther M., Johnatty, Sharon, Jones, Michael E., Kannisto, Paivi, Karlan, Beth Y., Karnezis, Anthony, Kast, Karin, Kennedy, Catherine J., Khusnutdinova, Elza, Kiemeney, Lambertus A., Kiiski, Johanna I., Kim, Sung-Won, Kjaer, Susanne K., Kobel, Martin, Kopperud, Reidun K., Kruse, Torben A., Kupryjanczyk, Jolanta, Kwong, Ava, Laitman, Yael, Lambrechts, Diether, Larranaga, Nerea, Larson, Melissa C., Lazaro, Conxi, Le, Nhu D., Le Marchand, Loic, Lee, Jong Won, Lele, Shashikant B., Leminen, Arto, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Levine, Douglas A., Liang, Dong, Liebrich, Clemens, Lilyquist, Jenna, Lipworth, Loren, Lissowska, Jolanta, Lu, Karen H., Lubinski, Jan, Luccarini, Craig, Lundvall, Lene, Mai, Phuong L., Mendoza-Fandino, Gustavo, Manoukian, Siranoush, Massuger, Leon F. A. G., May, Taymaa, Mazoyer, Sylvie, McAlpine, Jessica N., McGuire, Valerie, McLaughlin, John R., McNeish, Iain, Meijers-Heijboer, Hanne, Meindl, Alfons, Menon, Usha, Mensenkamp, Arjen R., Merritt, Melissa A., Milne, Roger L., Mitchell, Gillian, Modugno, Francesmary, Moes-Sosnowska, Joanna, Moffitt, Melissa, Montagna, Marco, Moysich, Kirsten B., Mulligan, Anna Marie, Musinsky, Jacob, Nathanson, Katherine L., Nedergaard, Lotte, Ness, Roberta B., Neuhausen, Susan L., Nevanlinna, Heli, Niederacher, Dieter, Nussbaum, Robert L., Odunsi, Kunle, Olah, Edith, Olopade, Olufunmilayo I., Olsson, Hakan, Olswold, Curtis, O'Malley, David M., Ong, Kai-ren, Onland-Moret, N. Charlotte, Orr, Nicholas, Orsulic, Sandra, Osorio, Ana, Palli, Domenico, Papi, Laura, Park-Simon, Tjoung-Won, Paul, James, Pearce, Celeste L., Pedersen, Inge Sokilde, Peeters, Petra H. M., Peissel, Bernard, Peixoto, Ana, Pejovic, Tanja, Pelttari, Liisa M., Permuth, Jennifer B., Peterlongo, Paolo, Pezzani, Lidia, Pfeiler, Georg, Phillips, Kelly-Anne, Piedmonte, Marion, Pike, Malcolm C., Piskorz, Anna M., Poblete, Samantha R., Pocza, Timea, Poole, Elizabeth M., Poppe, Bruce, Porteous, Mary E., Prieur, Fabienne, Prokofyeva, Darya, Pugh, Elizabeth, Pujana, Miquel Angel, Pujol, Pascal, Radice, Paolo, Rantala, Johanna, Rappaport-Fuerhauser, Christine, Rennert, Gad, Rhiem, Kerstin, Rice, Patricia, Richardson, Andrea, Robson, Mark, Rodriguez, Gustavo C., Rodriguez-Antona, Cristina, Romm, Jane, Rookus, Matti A., Rossing, Mary Anne, Rothstein, Joseph H., Rudolph, Anja, Runnebaum, Ingo B., Salvesen, Helga B., Sandler, Dale P., Schoemaker, Minouk J., Senter, Leigha, Setiawan, V. Wendy, Severi, Gianluca, Sharma, Priyanka, Shelford, Tameka, Siddiqui, Nadeem, Side, Lucy E., Sieh, Weiva, Singer, Christian F., Sobol, Hagay, Song, Honglin, Southey, Melissa C., Spurdle, Amanda B., Stadler, Zsofia, Steinemann, Doris, Stoppa-Lyonnet, Dominique, Sucheston-Campbell, Lara E., Sukiennicki, Grzegorz, Sutphen, Rebecca, Sutter, Christian, Swerdlow, Anthony J., Szabo, Csilla I., Szafron, Lukasz, Tan, Yen Y., Taylor, Jack A., Tea, Muy-Kheng, Teixeira, Manuel R., Teo, Soo-Hwang, Terry, Kathryn L., Thompson, Pamela J., Thomsen, Liv Cecilie Vestrheim, Thull, Darcy L., Tihomirova, Laima, Tinker, Anna V., Tischkowitz, Marc, Tognazzo, Silvia, Toland, Amanda Ewart, Tone, Alicia, Trabert, Britton, Travis, Ruth C., Trichopoulou, Antonia, Tung, Nadine, Tworoger, Shelley S., Van Altena, Anne M., Van den Berg, David, van der Hout, Annemarie H., van der Luijt, Rob B., Van Heetvelde, Mattias, Van Nieuwenhuysen, Els, Van Rensburg, Elizabeth J., Vanderstichele, Adriaan, Varon-Mateeva, Raymonda, Vega, Ana, Edwards, Digna Velez, Vergote, Ignace, Vierkant, Robert A., Vijai, Joseph, Vratimos, Athanassios, Walker, Lisa, Walsh, Christine, Wand, Dorothea, Wang-Gohrke, Shan, Wappenschmidt, Barbara, Webb, Penelope M., Weinberg, Clarice R., Weitzel, Jeffrey N., Wentzensen, Nicolas, Whittemore, Alice S., Wijnen, Juul T., Wilkens, Lynne R., Wolk, Alicja, Woo, Michelle, Wu, Xifeng, Wu, Anna H., Yang, Hannah, Yannoukakos, Drakoulis, Ziogas, Argyrios, Zorn, Kristin K., Narod, Steven A., Easton, Douglas F., Amos, Christopher I., Schildkraut, Joellen M., Ramus, Susan J., Ottini, Laura, Goodman, Marc T., Park-, Sue K., Kelemen, Linda E., Risch, Harvey A., Thomassen, Mads, Offit, Kenneth, Simard, Jacques, Schmutzler, Rita Katharina, Hazelett, Dennis, Monteiro, Alvaro N., Couch, Fergus J., Berchuck, Andrew, Chenevix-Trench, Georgia, Goode, Ellen L., Sellers, Thomas A., Gayther, Simon A., Antoniou, Antonis C., and Pharoah, Paul D. P.

Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

Published
2017

100. Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Author

Kar, Siddhartha P, Adler, Emily, Tyrer, Jonathan, Hazelett, Dennis, Anton-Culver, Hoda, Bandera, Elisa V, Beckmann, Matthias W, Berchuck, Andrew, Bogdanova, Natalia, Brinton, Louise, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Dansonka-Mieszkowska, Agnieszka, Doherty, Jennifer Anne, Dörk, Thilo, Dürst, Matthias, Eccles, Diana, Fasching, Peter A, Flanagan, James, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Heitz, Florian, Hildebrandt, Michelle A T, Høgdall, Estrid, Høgdall, Claus K, Huntsman, David G, Jensen, Allan, Karlan, Beth Y, Kelemen, Linda E, Kiemeney, Lambertus A, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Levine, Douglas A, Li, Qiyuan, Lissowska, Jolanta, Lu, Karen H, Lubiński, Jan, Massuger, Leon F A G, McGuire, Valerie, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Monteiro, Alvaro N, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Paul, James, Pearce, Celeste L, Pejovic, Tanja, Permuth, Jennifer B, Phelan, Catherine, Pike, Malcolm C, Poole, Elizabeth M, Ramus, Susan J, Risch, Harvey A, Rossing, Mary Anne, Salvesen, Helga B, Schildkraut, Joellen M, Sellers, Thomas A, Sherman, Mark, Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa, Terry, Kathryn L, Tworoger, Shelley S, Walsh, Christine, Wentzensen, Nicolas, Whittemore, Alice S, Wu, Anna H, Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Freedman, Matthew L, Gayther, Simon A, Pharoah, Paul D P, Lawrenson, Kate, Kar, Siddhartha P, Adler, Emily, Tyrer, Jonathan, Hazelett, Dennis, Anton-Culver, Hoda, Bandera, Elisa V, Beckmann, Matthias W, Berchuck, Andrew, Bogdanova, Natalia, Brinton, Louise, Butzow, Ralf, Campbell, Ian, Carty, Karen, Chang-Claude, Jenny, Cook, Linda S, Cramer, Daniel W, Cunningham, Julie M, Dansonka-Mieszkowska, Agnieszka, Doherty, Jennifer Anne, Dörk, Thilo, Dürst, Matthias, Eccles, Diana, Fasching, Peter A, Flanagan, James, Gentry-Maharaj, Aleksandra, Glasspool, Rosalind, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Heitz, Florian, Hildebrandt, Michelle A T, Høgdall, Estrid, Høgdall, Claus K, Huntsman, David G, Jensen, Allan, Karlan, Beth Y, Kelemen, Linda E, Kiemeney, Lambertus A, Kjaer, Susanne K, Kupryjanczyk, Jolanta, Lambrechts, Diether, Levine, Douglas A, Li, Qiyuan, Lissowska, Jolanta, Lu, Karen H, Lubiński, Jan, Massuger, Leon F A G, McGuire, Valerie, McNeish, Iain, Menon, Usha, Modugno, Francesmary, Monteiro, Alvaro N, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Paul, James, Pearce, Celeste L, Pejovic, Tanja, Permuth, Jennifer B, Phelan, Catherine, Pike, Malcolm C, Poole, Elizabeth M, Ramus, Susan J, Risch, Harvey A, Rossing, Mary Anne, Salvesen, Helga B, Schildkraut, Joellen M, Sellers, Thomas A, Sherman, Mark, Siddiqui, Nadeem, Sieh, Weiva, Song, Honglin, Southey, Melissa, Terry, Kathryn L, Tworoger, Shelley S, Walsh, Christine, Wentzensen, Nicolas, Whittemore, Alice S, Wu, Anna H, Yang, Hannah, Zheng, Wei, Ziogas, Argyrios, Freedman, Matthew L, Gayther, Simon A, Pharoah, Paul D P, and Lawrenson, Kate

Abstract

BACKGROUND: Genome-wide association studies (GWAS) have identified 18 loci associated with serous ovarian cancer (SOC) susceptibility but the biological mechanisms driving these findings remain poorly characterised. Germline cancer risk loci may be enriched for target genes of transcription factors (TFs) critical to somatic tumorigenesis.METHODS: All 615 TF-target sets from the Molecular Signatures Database were evaluated using gene set enrichment analysis (GSEA) and three GWAS for SOC risk: discovery (2196 cases/4396 controls), replication (7035 cases/21 693 controls; independent from discovery), and combined (9627 cases/30 845 controls; including additional individuals).RESULTS: The PAX8-target gene set was ranked 1/615 in the discovery (PGSEA<0.001; FDR=0.21), 7/615 in the replication (PGSEA=0.004; FDR=0.37), and 1/615 in the combined (PGSEA<0.001; FDR=0.21) studies. Adding other genes reported to interact with PAX8 in the literature to the PAX8-target set and applying an alternative to GSEA, interval enrichment, further confirmed this association (P=0.006). Fifteen of the 157 genes from this expanded PAX8 pathway were near eight loci associated with SOC risk at P<10(-5) (including six with P<5 × 10(-8)). The pathway was also associated with differential gene expression after shRNA-mediated silencing of PAX8 in HeyA8 (PGSEA=0.025) and IGROV1 (PGSEA=0.004) SOC cells and several PAX8 targets near SOC risk loci demonstrated in vitro transcriptomic perturbation.CONCLUSIONS: Putative PAX8 target genes are enriched for common SOC risk variants. This finding from our agnostic evaluation is of particular interest given that PAX8 is well-established as a specific marker for the cell of origin of SOC.

Published
2017

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