51. Nephroangiosclerosis not related to hypertension: a matter to resolve in the era of precision medicine
- Author
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Antonietta Gigante, Silvia Lai, Chiara Pellicano, Oriana De Marco, Edoardo Rosato, Konstantinos Giannakakis, Giulia D’Amati, Maurizio Muscaritoli, Claudio Ferri, and Rosario Cianci
- Subjects
hypertension ,nephroangiosclerosis (NAS) ,renal diseases ,Internal Medicine ,chronic kidney disease (CKD) ,glomerulonephritis (GN) - Abstract
Nephroangiosclerosis (NAS) associated with hypertension continues to be one of the most causes of end stage renal diseases in Europe, but it is still poorly studied. The prevalence of NAS shows a large variability due to the difference among different countries regarding clinical presentations and the indication to perform renal biopsy. The study aimed to investigate the prevalence in biopsy-proven NAS patients and the association with hypertension and/or glomerulonephritis (GN). We included all patients referred for native kidney biopsy between 2003–2021 at Policlinic Umberto I of Rome. From 837 patients who underwent renal biopsy NAS was diagnosed in 80 (10.5%) patients. Serum creatinine was significantly higher in NAS [2.07 mg/dl (IQR 1.13–5.2) vs 1.1 mg/dl (IQR 0.8–2.1), p 0.05). IgA nephropathy, focal segmental glomerulosclerosis and membranous nephropathy were the most frequent GN associated. In conclusion no specific feautures are reported in NAS with and without hypertension. More informations on the phenotype, clinical presentation and markers are needed to improve histological and clinical diagnostics.
- Published
- 2022