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52. Adaptation of Brucella melitensis Antimicrobial Susceptibility Testing to the ISO 20776 Standard and Validation of the Method

Author

Tscherne, Alina, primary, Mantel, Enrico, additional, Boskani, Talar, additional, Budniak, Sylwia, additional, Elschner, Mandy, additional, Fasanella, Antonio, additional, Feruglio, Siri L., additional, Galante, Domenico, additional, Giske, Christian G., additional, Grunow, Roland, additional, Henczko, Judit, additional, Hinz, Christin, additional, Iwaniak, Wojciech, additional, Jacob, Daniela, additional, Kedrak-Jablonska, Agnieszka, additional, Jensen, Veronica K., additional, Johansen, Tone B., additional, Kahlmeter, Gunnar, additional, Manzulli, Viviana, additional, Matuschek, Erika, additional, Melzer, Falk, additional, Nuncio, Maria S., additional, Papaparaskevas, Joseph, additional, Pelerito, Ana, additional, Solheim, Margrete, additional, Thomann, Susanne, additional, Tsakris, Athanasios, additional, Wahab, Tara, additional, Weiner, Marcin, additional, Zoeller, Lothar, additional, and Zange, Sabine, additional

Published
2022
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55. Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

Author

Mikaeloff, Flora, primary, Gelpi, Marco, additional, Benfeitas, Rui, additional, Knudsen, Andreas D., additional, Vestad, Beate, additional, Høgh, Julie, additional, Hov, Johannes R., additional, Benfield, Thomas, additional, Murray, Daniel, additional, Giske, Christian G, additional, Mardinoglu, Adil, additional, Trøseid, Marius, additional, Nielsen, Susanne D., additional, and Neogi, Ujjwal, additional

Published
2022
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65. High diversity of blaNDM-1-encoding plasmids in Klebsiella pneumoniae isolated from neonates in a Vietnamese hospital

Author

KK, Sriram, primary, Ekedahl, Elina, additional, Hoang, Ngoc Thi Bich, additional, Sewunet, Tsegaye, additional, Berglund, Björn, additional, Lundberg, Ludwig, additional, Nematzadeh, Shoeib, additional, Nilsson, Maud, additional, Nilsson, Lennart E, additional, Le, Ngai Kien, additional, Tran, Dien Minh, additional, Hanberger, Håkan, additional, Olson, Linus, additional, Larsson, Mattias, additional, Giske, Christian G., additional, and Westerlund, Fredrik, additional

Published
2022
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67. Staphylococcus aureus bloodstream infections: diverging trends of meticillin-resistant and meticillin-susceptible isolates, EU/EEA, 2005 to 2018

Author

Gagliotti, Carlo, Högberg, Liselotte Diaz, Billström, Hanna, Eckmanns, Tim, Giske, Christian G, Heuer, Ole E, Jarlier, Vincent, Kahlmeter, Gunnar, Lo Fo Wong, Danilo, Monen, Jos, Murchan, Stephen, Simonsen, Gunnar Skov, Šubelj, Maja, Andrašević, Arjana Tambić, Żabicka, Dorota, Žemličková, Helena, and Monnet, Dominique L

Subjects
Europe, Staphylococcus aureus, bacterial infections, bloodstream infection, MRSA, antimicrobial resistance, bacterial infections and mycoses, human activities
Abstract

BackgroundInvasive infections caused by Staphylococcus aureus have high clinical and epidemiological relevance. It is therefore important to monitor the S. aureus trends using suitable methods.AimThe study aimed to describe the trends of bloodstream infections (BSI) caused by meticillin-resistant S. aureus (MRSA) and meticillin-susceptible S. aureus (MSSA) in the European Union (EU) and the European Economic Area (EEA).MethodsAnnual data on S. aureus BSI from 2005 to 2018 were obtained from the European Antimicrobial Resistance Surveillance Network (EARS-Net). Trends of BSI were assessed at the EU/EEA level by adjusting for blood culture set rate (number of blood culture sets per 1,000 days of hospitalisation) and stratification by patient characteristics.ResultsConsidering a fixed cohort of laboratories consistently reporting data over the entire study period, MRSA percentages among S. aureus BSI decreased from 30.2% in 2005 to 16.3% in 2018. Concurrently, the total number of BSI caused by S. aureus increased by 57%, MSSA BSI increased by 84% and MRSA BSI decreased by 31%. All these trends were statistically significant (p

Published
2021

68. In Vitro Activity of Omadacycline and Five Comparators against Contemporary Ribotypes of Clostridioides difficile in Stockholm, Sweden

Author

Camporeale, Angela, Tellapragada, Chaitanya, Kornijenko, Jelena, Nord, Carl Erik, and Giske, Christian G.

Subjects
Clostridioides difficile, Observation, omadacycline, agar dilution method, Microbiology, QR1-502
Abstract

Clostridioides difficile infection represents a growing clinical challenge. The new compound omadacycline is a potential treatment alternative, as many antibiotics have limited activity or are rarely used due to costs and side effects. The activity of omadacycline and five comparators was assessed with agar dilution on a 2015-to-2018 collection of 65 C. difficile isolates from Sweden. Omadacycline demonstrated in vitro activity against the contemporary ribotypes of C. difficile, and further clinical investigation is needed. IMPORTANCE Evaluating the activity of novel antimicrobials like omadacycline is of great interest, as a reliable and efficient antimicrobial treatment for Clostridioides difficile infections is in demand.

Published
2021

75. Fecal carriage and clonal dissemination of blaNDM-1 carrying Klebsiella pneumoniae sequence type 147 at an intensive care unit in Lao PDR.

Author

Sewunet, Tsegaye, K. K., Sriram, Nguyen, Ha Hoang, Sithivong, Noikaseumsy, Hoang, Ngoc Thi Bich, Sychareun, Vanphanom, Nengmongvang, Kokasia, Larsson, Mattias, Olson, Linus, Westerlund, Fredrik, and Giske, Christian G.

Subjects
INTENSIVE care units, BETA lactamases, KLEBSIELLA pneumoniae, ESCHERICHIA coli, BACTERIAL genomes, INFECTION prevention
Abstract

Objectives: Carbapenemase-producing Enterobacterales (CPE) are high priority targets of global antimicrobial surveillance. Herein, we determined the colonization rate of CPE on admission to intensive care units in Vientiane, Lao PDR in August-September 2019. Methods: Data regarding clinical conditions, infection control, and antibiotic usage were collected during admission. Rectal swab samples (n = 137) collected during admission were inoculated to selective chromogenic agars, followed by confirmatory tests for extended-spectrum beta-lactamases and carbapenemases. All CPE isolates were sequenced on Illumina (HiSeq2500), reads assembled using SPAdes 3.13, and the draft genomes used to query a database (https://www.genomicepidemiology.org) for resistome, plasmid replicons, and sequence types (ST). Optical DNA mapping (ODM) was used to characterize plasmids and to determine location of resistance genes. Minimum spanning tree was generated using the Bacterial Isolate Genome Sequence database (BIGSdb) and annotated using iTOL. Result: From 47 Enterobacterales isolated on selective agars, K. pneumoniae (25/47) and E. coli (12/47) were the most prevalent species, followed by K aerogenes (2/47), K. variicola (1/47), and K. oxytoca (1/47). The overall prevalence of ESBLs was 51.0%; E. coli 83.3% (10/12) and Klebsiella spp. 41.3% (12/29). Twenty percent of the K. pneumoniae (5/25) isolates were carbapenem-resistant, and 4/5 contained the blaNDM-1 gene. All blaNDM-1 isolates belonged to ST147 and were indistinguishable with cgMLST. ODM showed that the blaNDM-1 gene was located on identical plasmids in all isolates. Conclusion: The prevalence of ESBL-producing Enterobacterales was high, while carbapenemases were less common. However, the detection of clonal dissemination of blaNDM-1-producing K. pneumoniae isolates in one of the intensive care units calls for vigilance. Stringent infection prevention and antimicrobial stewardship strategies are highly important measures. [ABSTRACT FROM AUTHOR]

Published
2022
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77. Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study

Author

Kumarasamy, Karthikeyan K, Toleman, Mark A, Walsh, Timothy R, Bagaria, Jay, Butt, Fafhana, Balakrishnan, Ravikumar, Chaudhary, Uma, Doumith, Michel, Giske, Christian G, Irfan, Seema, Krishnan, Padma, Kumar, Anil V, Maharjan, Sunil, Mushtaq, Shazad, Noorie, Tabassum, Paterson, David L, Pearson, Andrew, Perry, Claire, Pike, Rachel, Rao, Bhargavi, Ray, Ujjwayini, Sarma, Jayanta B, Sharma, Madhu, Sheridan, Elizabeth, Thirunarayan, Mandayam A, Turton, Jane, Upadhyay, Supriya, Warner, Marina, Welfare, William, Livermore, David M, and Woodford, Neil

Published
2010
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85. Reviving old antibiotics

Author

Theuretzbacher, Ursula, Van Bambeke, Françoise, Cantón, Rafael, Giske, Christian G., Mouton, Johan W., Nation, Roger L., Paul, Mical, Turnidge, John D., and Kahlmeter, Gunnar

Published
2015
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87. Additional file 3 of Comparative genome analysis of colistin-resistant OXA-48-producing Klebsiella pneumoniae clinical strains isolated from two Iranian hospitals

Author

Bolourchi, Negin, Shahcheraghi, Fereshteh, Giske, Christian G., Nematzadeh, Shoeib, Noori Goodarzi, Narjes, Solgi, Hamid, and Badmasti, Farzad

Abstract

Additional file 3: Figure S1. A) The genetic environment of blaOXA-48 and blaNDM-1 in 14 colistin-resistant OXA-48-producing K. pneumoniae strains. blaOXA-48 was identified in all strains except for P26. The lysR and blaOXA-48 complex was found in all strains. No transposase element was detected surrounding the lysR and blaOXA-48 complex in P6, P7, P40, P42 and P43. Two blaOXA-48 with different genetic arrangement were found on P32 plasmid. In P36, P37, P38 and P44; the lysR and blaOXA-48 complex was flanked upstream by IS91, IS4 and IS110 family transposase genes, respectively. B) blaNDM-1 was detected only in P6 and P26. blaNDM-1 was flanked upsteram by bleomycin binding protein and trpF genes and downstream by the IS91 family transposase.

Published
2021
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88. Additional file 2 of Comparative genome analysis of colistin-resistant OXA-48-producing Klebsiella pneumoniae clinical strains isolated from two Iranian hospitals

Author

Bolourchi, Negin, Shahcheraghi, Fereshteh, Giske, Christian G., Nematzadeh, Shoeib, Noori Goodarzi, Narjes, Solgi, Hamid, and Badmasti, Farzad

Abstract

Additional file 2: Table S2. Extrachromosomal Genetic and resistome information of 14 colistin-resistant OXA-48-producing K. pneumoniae strains.

Published
2021
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89. Additional file 1 of Comparative genome analysis of colistin-resistant OXA-48-producing Klebsiella pneumoniae clinical strains isolated from two Iranian hospitals

Author

Bolourchi, Negin, Shahcheraghi, Fereshteh, Giske, Christian G., Nematzadeh, Shoeib, Noori Goodarzi, Narjes, Solgi, Hamid, and Badmasti, Farzad

Subjects
polycyclic compounds, bacteria, biochemical phenomena, metabolism, and nutrition
Abstract

Additional file 1: Table S1. Genotypic, resistome profile and capsular and O-typing of 14 colistin-resistant OXA-48-producing K. pneumoniae strains.

Published
2021
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90. Systematic Comparison of Epidemic and Non-Epidemic Carbapenem Resistant Klebsiella pneumoniae Strains

Author

Koskinen, Katariina, Penttinen, Reetta, Örmälä-Odegrip, Anni-Maria, Giske, Christian G., Ketola, Tarmo, and Jalasvuori, Matti

Subjects
Microbiology (medical), antibiotic resistance, Immunology, extended-spectrum beta-lactamase, virulenssi, epidemiat, Microbiology, epidemic, bakteerit, virulence, Infectious Diseases, Klebsiella-bakteerit, XDR Klebsiella pneumoniae, antibioottiresistenssi
Abstract

Over the past few decades, extensively drug resistant (XDR) resistant Klebsiella pneumoniae has become a notable burden to healthcare all over the world. Especially carbapenemase-producing strains are problematic due to their capability to withstand even last resort antibiotics. Some sequence types (STs) of K. pneumoniae are significantly more prevalent in hospital settings in comparison to other equally resistant strains. This provokes the question whether or not there are phenotypic characteristics that may render certain K. pneumoniae more suitable for epidemic dispersal between patients, hospitals, and different environments. In this study, we selected seven epidemic and non-epidemic carbapenem resistant K. pneumoniae isolates for extensive systematic characterization for phenotypic and genotypic qualities in order to identify potential factors that precede or emerge from epidemic successfulness. Studied characteristics include growth rates and densities in different conditions (media, temperature, pH, resource levels), tolerance to alcohol and drought, inhibition between strains, ability to compensate pH, as well as various genomic features. Overall, there are clear differences between isolates, yet, only drought tolerance was found to notably associate with non-epidemic K. pneumoniae strains. We further report a preliminary study on the potential to control K. pneumoniae ST11 with an antimicrobial component produced by a non-epidemic K. pneumoniae. This component initially restricts bacterial growth, but stable resistance develops rapidly in vitro. peerReviewed

Published
2021

91. Combination versus monotherapy as definitive treatment for Pseudomonas aeruginosa bacteraemia: a multicentre retrospective observational cohort study

Author

Babich, Tanya, primary, Naucler, Pontus, additional, Valik, John Karlsson, additional, Giske, Christian G, additional, Benito, Natividad, additional, Cardona, Ruben, additional, Rivera, Alba, additional, Pulcini, Celine, additional, Abdel Fattah, Manal, additional, Haquin, Justine, additional, MacGowan, Alasdair, additional, Grier, Sally, additional, Gibbs, Julie, additional, Chazan, Bibiana, additional, Yanovskay, Anna, additional, Ami, Ronen Ben, additional, Landes, Michal, additional, Nesher, Lior, additional, Zaidman-Shimshovitz, Adi, additional, McCarthy, Kate, additional, Paterson, David L, additional, Tacconelli, Evelina, additional, Buhl, Michael, additional, Mauer, Susanna, additional, Rodriguez-Bano, Jesus, additional, Morales, Isabel, additional, Oliver, Antonio, additional, Ruiz de Gopegui, Enrique, additional, Cano, Angela, additional, Machuca, Isabel, additional, Gozalo-Marguello, Monica, additional, Martinez, Luis Martinez, additional, Gonzalez-Barbera, Eva M, additional, Alfaro, Iris Gomez, additional, Salavert, Miguel, additional, Beovic, Bojana, additional, Saje, Andreja, additional, Mueller-Premru, Manica, additional, Pagani, Leonardo, additional, Vitrat, Virginie, additional, Kofteridis, Diamantis, additional, Zacharioudaki, Maria, additional, Maraki, Sofia, additional, Weissman, Yulia, additional, Paul, Mical, additional, Dickstein, Yaakov, additional, Leibovici, Leonard, additional, and Yahav, Dafna, additional

Published
2021
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92. Systematic review and meta-analysis of in vitro efficacy of antibiotic combination therapy against carbapenem-resistant Gram-negative bacilli

Author

Scudeller, Luigia, primary, Righi, Elda, additional, Chiamenti, Margherita, additional, Bragantini, Damiano, additional, Menchinelli, Giulia, additional, Cattaneo, Paolo, additional, Giske, Christian G., additional, Lodise, Thomas, additional, Sanguinetti, Maurizio, additional, Piddock, Laura J.V., additional, Franceschi, François, additional, Ellis, Sally, additional, Carrara, Elena, additional, Savoldi, Alessia, additional, and Tacconelli, Evelina, additional

Published
2021
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100. Effective antimicrobial combination in vivo treatment predicted with microcalorimetry screening

Author

Kragh, Kasper Nørskov, primary, Gijón, Desiree, additional, Maruri, Ainhize, additional, Antonelli, Alberto, additional, Coppi, Marco, additional, Kolpen, Mette, additional, Crone, Stephanie, additional, Tellapragada, Chaitanya, additional, Hasan, Badrul, additional, Radmer, Stine, additional, de Vogel, Corné, additional, van Wamel, Willem, additional, Verbon, Annelies, additional, Giske, Christian G, additional, Rossolini, Gian Maria, additional, Cantón, Rafael, additional, and Frimodt-Møller, Niels, additional

Published
2021
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