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The respiratory epithelium is frequently infected by the respiratory syncytial virus, resulting in inflammation, a reduction in cilia activity and an increase in the production of mucus.

[EN] Simulation models for the transport of water and nitrogen in the soil are useful tools for evaluating the consequen-ces of di erent crop management practices without waiting until the end of the crop cycle. Particularly, simplecompartmental models for the transport of water and nitrogen are based on the solution of mass balance equationsfor the water and a system of ordinary di erential equations for the nitrogen cycle. In this work, these modelsare used to evaluate di erent possible scenarios of irrigation and nitrogen fertilization in a cauli ower crop, as apractical work for the students of Horticulture course. The results show that di erent irrigation and fertilizationstrategies lead to di erent results for the nitrate leaching, water drainage and nitrogen uptake [ES] Los modelos de simulación del transporte de agua y nitrógeno en el suelo son herramientas útiles para evaluar distintas prácticas de cultivo sin necesidad de tener que esperar a que se complete el ciclo de crecimiento. En concreto, los modelos compartimentales sencillos para el agua y el nitrógeno en el suelo se basan en ecuaciones de balance de masa y en la resolución de un sistema de ecuaciones diferenciales ordinarias. Se plantea la posibilidad de utilizar este tipo de modelos en las prácticas de la asignatura Horticultura, evaluando distintos escenarios posibles de riego y abonado en un cultivo de coliflor. Los resultados muestran que distintas prácticas de cultivo producen diferencias en la lixiviación de nitrato y en la extracción de nitrógeno por el cultivo.

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized clinically by progressive motor impairment, cognitive decline, and emotional deterioration. The disease is caused by the abnormal expansion of a CAG trinucleotide repeat in the first exon of the huntingtin gene in chromosome 4p16.3. HD is spread worldwide and it is generally accepted that few mutational events account for the origin of the pathogenic CAG expansion in most populations. We have investigated the genetic history of HD mutation in 83 family probands from the Land of Valencia, in Eastern Spain. An analysis of the HD/CCG repeat in informative families suggested that at least two main chromosomes were associated in the Valencian population, one associated with allele 7 (77 mutant chromosomes) and one associated with allele 10 (two mutant chromosomes). Haplotype A-7-A (H1) was observed in 47 out of 48 phase-known mutant chromosomes, obtained by segregation analysis, through the haplotype analysis of rs1313770-HD/CCG-rs82334, as it also was in 120 out of 166 chromosomes constructed by means of the PHASE program. The genetic history and geographical distribution of the main haplotype H1 were both studied by constructing extended haplotypes with flanking short tandem repeats (STRs) D4S106 and D4S3034. We found that we were able to determine the age of the CAG expansion associated with the haplotype H1 as being between 4,700 and 10,000 years ago. Furthermore, we observed a nonhomogenous distribution in the different regions associated with the different extended haplotypes of the ancestral haplotype H1, suggesting that local founder effects have occurred.