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51. Admixture mapping of peripheral artery disease in a Dominican population reveals a putative risk locus on 2q35

Author

Cullina, Sinead, primary, Wojcik, Genevieve L., additional, Shemirani, Ruhollah, additional, Klarin, Derek, additional, Gorman, Bryan R., additional, Sorokin, Elena P., additional, Gignoux, Christopher R., additional, Belbin, Gillian M., additional, Pyarajan, Saiju, additional, Asgari, Samira, additional, Tsao, Philip S., additional, Damrauer, Scott M., additional, Abul-Husn, Noura S., additional, and Kenny, Eimear E., additional

Published
2023
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52. Ancestral diversity in lipoprotein(a) studies helps address evidence gaps

Author

Lee, Moa P, primary, Dimos, Sofia F, additional, Raffield, Laura M, additional, Wang, Zhe, additional, Ballou, Anna F, additional, Downie, Carolina G, additional, Arehart, Christopher H, additional, Correa, Adolfo, additional, de Vries, Paul S, additional, Du, Zhaohui, additional, Gignoux, Christopher R, additional, Gordon-Larsen, Penny, additional, Guo, Xiuqing, additional, Haessler, Jeffrey, additional, Howard, Annie Green, additional, Hu, Yao, additional, Kassahun, Helina, additional, Kent, Shia T, additional, Lopez, J Antonio G, additional, Monda, Keri L, additional, North, Kari E, additional, Peters, Ulrike, additional, Preuss, Michael H, additional, Rich, Stephen S, additional, Rhodes, Shannon L, additional, Yao, Jie, additional, Yarosh, Rina, additional, Tsai, Michael Y, additional, Rotter, Jerome I, additional, Kooperberg, Charles L, additional, Loos, Ruth J F, additional, Ballantyne, Christie, additional, Avery, Christy L, additional, and Graff, Mariaelisa, additional

Published
2023
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53. Socioeconomic Status and Childhood Asthma in Urban Minority Youths. The GALA II and SAGE II Studies

Author

Thakur, Neeta, Oh, Sam S, Nguyen, Elizabeth A, Martin, Melissa, Roth, Lindsey A, Galanter, Joshua, Gignoux, Christopher R, Eng, Celeste, Davis, Adam, Meade, Kelley, LeNoir, Michael A, Avila, Pedro C, Farber, Harold J, Serebrisky, Denise, Brigino-Buenaventura, Emerita, Rodriguez-Cintron, William, Kumar, Rajesh, Williams, L Keoki, Bibbins-Domingo, Kirsten, Thyne, Shannon, Sen, Saunak, Rodriguez-Santana, Jose R, Borrell, Luisa N, and Burchard, Esteban G

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Asthma, Behavioral and Social Science, Lung, Pediatric, Clinical Research, Basic Behavioral and Social Science, Aetiology, 2.3 Psychological, social and economic factors, Respiratory, Adolescent, Black or African American, Case-Control Studies, Child, Educational Status, Female, Hispanic or Latino, Humans, Income, Insurance, Health, Logistic Models, Male, Mexican Americans, Minority Health, Odds Ratio, Risk Factors, San Francisco, Social Class, Surveys and Questionnaires, Urban Health, Young Adult, asthma, health status disparities, minority health, educational status, poverty, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

RationaleThe burden of asthma is highest among socioeconomically disadvantaged populations; however, its impact is differentially distributed among racial and ethnic groups.ObjectivesTo assess the collective effect of maternal educational attainment, annual household income, and insurance type on childhood asthma among minority, urban youth.MethodsWe included Mexican American (n = 485), other Latino (n = 217), and African American (n = 1,141) children (aged 8-21 yr) with and without asthma from the San Francisco Bay Area. An index was derived from maternal educational attainment, annual household income, and insurance type to assess the collective effect of socioeconomic status on predicting asthma. Logistic regression stratified by racial and ethnic group was used to estimate adjusted odds ratios (aOR) and their 95% confidence intervals (CI). We further examined whether acculturation explained the socioeconomic-asthma association in our Latino population.Measurements and main resultsIn the adjusted analyses, African American children had 23% greater odds of asthma with each decrease in the socioeconomic index (aOR, 1.23; 95% CI, 1.09-1.38). Conversely, Mexican American children have 17% reduced odds of asthma with each decrease in the socioeconomic index (aOR, 0.83; 95% CI, 0.72-0.96) and this relationship was not fully explained by acculturation. This association was not observed in the other Latino group.ConclusionsSocioeconomic status plays an important role in predicting asthma, but has different effects depending on race and ethnicity. Further steps are necessary to better understand the risk factors through which socioeconomic status could operate in these populations to prevent asthma.

Published
2013

54. Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: The Genes-environments and Admixture in Latino Asthmatics (GALA II) study

Author

Kumar, Rajesh, Nguyen, Elizabeth A, Roth, Lindsey A, Oh, Sam S, Gignoux, Christopher R, Huntsman, Scott, Eng, Celeste, Moreno-Estrada, Andres, Sandoval, Karla, Peñaloza-Espinosa, Rosenda I, López-López, Marisol, Avila, Pedro C, Farber, Harold J, Tcheurekdjian, Haig, Rodriguez-Cintron, William, Rodriguez-Santana, Jose R, Serebrisky, Denise, Thyne, Shannon M, Williams, L Keoki, Winkler, Cheryl, Bustamante, Carlos D, Pérez-Stable, Eliseo J, Borrell, Luisa N, and Burchard, Esteban G

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Lung, Asthma, Pediatric, Clinical Research, Adolescent, Allergens, Black People, Case-Control Studies, Child, Child, Preschool, Emigration and Immigration, Female, Gene-Environment Interaction, Hispanic or Latino, Humans, Hypersensitivity, Immediate, Male, Prevalence, Puerto Rico, Risk Factors, Skin Tests, United States, Latino, atopy, region of origin, genetic ancestry, immigration, kin test, aeroallergen, GALA II, Genes-environments and Admixture in Latino Asthmatics, OR, Odds ratio, SES, SNP, Single nucleotide polymorphism, Socioeconomic status, ZINB, Zero-inflated negative binomial, skin test, Immunology, Allergy
Abstract

BackgroundAtopy varies by ethnicity, even within Latino groups. This variation might be due to environmental, sociocultural, or genetic factors.ObjectiveWe sought to examine risk factors for atopy within a nationwide study of US Latino children with and without asthma.MethodsAeroallergen skin test responses were analyzed in 1830 US Latino subjects. Key determinants of atopy included country/region of origin, generation in the United States, acculturation, genetic ancestry, and site to which subjects migrated. Serial multivariate zero-inflated negative binomial regressions stratified by asthma status examined the association of each key determinant variable with the number of positive skin test responses. In addition, the independent effect of each key variable was determined by including all key variables in the final models.ResultsIn baseline analyses African ancestry was associated with 3 times (95% CI, 1.62-5.57) as many positive skin test responses in asthmatic participants and 3.26 times (95% CI, 1.02-10.39) as many positive skin test responses in control participants. Generation and recruitment site were also associated with atopy in crude models. In final models adjusted for key variables, asthmatic patients of Puerto Rican (exp[β] [95% CI], 1.31 [1.02-1.69]) and mixed (exp[β] [95% CI], 1.27 [1.03-1.56]) ethnicity had a greater probability of positive skin test responses compared with Mexican asthmatic patients. Ancestry associations were abrogated by recruitment site but not region of origin.ConclusionsPuerto Rican ethnicity and mixed origin were associated with degree of atopy within US Latino children with asthma. African ancestry was not associated with degree of atopy after adjusting for recruitment site. Local environment variation, represented by site, was associated with degree of sensitization.

Published
2013

55. A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations

Author

Levin, Albert M, Mathias, Rasika A, Huang, Lili, Roth, Lindsey A, Daley, Denise, Myers, Rachel A, Himes, Blanca E, Romieu, Isabelle, Yang, Mao, Eng, Celeste, Park, Julie E, Zoratti, Karla, Gignoux, Christopher R, Torgerson, Dara G, Galanter, Joshua M, Huntsman, Scott, Nguyen, Elizabeth A, Becker, Allan B, Chan-Yeung, Moira, Kozyrskyj, Anita L, Kwok, Pui-Yan, Gilliland, Frank D, Gauderman, W James, Bleecker, Eugene R, Raby, Benjamin A, Meyers, Deborah A, London, Stephanie J, Martinez, Fernando D, Weiss, Scott T, Burchard, Esteban G, Nicolae, Dan L, Ober, Carole, Barnes, Kathleen C, and Williams, L Keoki

Subjects
Biomedical and Clinical Sciences, Immunology, Lung, Human Genome, Clinical Research, Genetics, Asthma, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Adolescent, Adult, Black or African American, Aged, Aged, 80 and over, Canada, Case-Control Studies, Child, Child, Preschool, Female, Genome-Wide Association Study, HLA-DQ beta-Chains, Hispanic or Latino, Humans, Immunoglobulin E, Male, Middle Aged, Polymorphism, Single Nucleotide, United States, White People, Meta-analysis, genome-wide association study, total IgE, race-ethnicity, continental population groups, Allergy
Abstract

BackgroundIgE is both a marker and mediator of allergic inflammation. Despite reported differences in serum total IgE levels by race-ethnicity, African American and Latino subjects have not been well represented in genetic studies of total IgE.ObjectiveWe sought to identify the genetic predictors of serum total IgE levels.MethodsWe used genome-wide association data from 4292 subjects (2469 African Americans, 1564 European Americans, and 259 Latinos) in the EVE Asthma Genetics Consortium. Tests for association were performed within each cohort by race-ethnic group (ie, African American, Latino, and European American) and asthma status. The resulting P values were meta-analyzed, accounting for sample size and direction of effect. Top single nucleotide polymorphism associations from the meta-analysis were reassessed in 6 additional cohorts comprising 5767 subjects.ResultsWe identified 10 unique regions in which the combined association statistic was associated with total serum IgE levels (P

Published
2013

56. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans

Author

Myers, Rachel A, Himes, Blanca E, Gignoux, Christopher R, Yang, James J, Gauderman, W James, Rebordosa, Cristina, Xie, Jianming, Torgerson, Dara G, Levin, Albert M, Baurley, James, Graves, Penelope E, Mathias, Rasika A, Romieu, Isabelle, Roth, Lindsey A, Conti, David, Avila, Lydiana, Eng, Celeste, Vora, Hita, LeNoir, Michael A, Soto-Quiros, Manuel, Liu, Jinghua, Celedón, Juan C, Galanter, Joshua M, Farber, Harold J, Kumar, Rajesh, Avila, Pedro C, Meade, Kelley, Serebrisky, Denise, Thyne, Shannon, Rodriguez-Cintron, William, Rodriguez-Santana, Jose R, Borrell, Luisa N, Lemanske, Robert F, Bleecker, Eugene R, Meyers, Deborah A, London, Stephanie J, Barnes, Kathleen C, Raby, Benjamin A, Martinez, Fernando D, Gilliland, Frank D, Williams, L Keoki, Burchard, Esteban G, Weiss, Scott T, Nicolae, Dan L, and Ober, Carole

Subjects
Genetics, Asthma, Lung, Human Genome, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Black or African American, Chromosomes, Human, Pair 19, DNA Mutational Analysis, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino, Humans, Kallikreins, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Prostate-Specific Antigen, Risk Factors, United States, White People, genetic risk factors, meta-analysis, KLK3, Immunology, Allergy
Abstract

BackgroundGenome-wide association studies of asthma have implicated many genetic risk factors, with well-replicated associations at approximately 10 loci that account for only a small proportion of the genetic risk.ObjectivesWe aimed to identify additional asthma risk loci by performing an extensive replication study of the results from the EVE Consortium meta-analysis.MethodsWe selected 3186 single nucleotide polymorphisms for replication based on the P values from the EVE Consortium meta-analysis. These single nucleotide polymorphisms were genotyped in ethnically diverse replication samples from 9 different studies, totaling 7202 cases, 6426 controls, and 507 case-parent trios. Association analyses were conducted within each participating study, and the resulting test statistics were combined in a meta-analysis.ResultsTwo novel associations were replicated in European Americans: rs1061477 in the KLK3 gene on chromosome 19 (combined odds ratio = 1.18; 95% CI, 1.10-1.25) and rs9570077 (combined odds ratio =1.20; 95% CI, 1.12-1.29) on chromosome 13q21. We could not replicate any additional associations in the African Americans or Latinos.ConclusionsThis extended replication study identified 2 additional asthma risk loci in populations of European descent. The absence of additional loci for African Americans and Latinos highlights the difficulty in replicating associations in admixed populations.

Published
2012

57. Whole-genome sequencing of 175 Mongolians uncovers population-specific genetic architecture and gene flow throughout North and East Asia

Author

Bai, Haihua, Guo, Xiaosen, Narisu, Narisu, Lan, Tianming, Wu, Qizhu, Xing, Yanping, Zhang, Yong, Bond, Stephen R., Pei, Zhili, Zhang, Yanru, Zhang, Dandan, Jirimutu, Jirimutu, Zhang, Dong, Yang, Xukui, Morigenbatu, Morigenbatu, Zhang, Li, Ding, Bingyi, Guan, Baozhu, Cao, Junwei, Lu, Haorong, Liu, Yiyi, Li, Wangsheng, Dang, Ningxin, Jiang, Mingyang, Wang, Shenyuan, Xu, Huixin, Wang, Dingzhu, Liu, Chunxia, Luo, Xin, Gao, Ying, Li, Xueqiong, Wu, Zongze, Yang, Liqing, Meng, Fanhua, Ning, Xiaolian, Hashenqimuge, Hashenqimuge, Wu, Kaifeng, Wang, Bo, Suyalatu, Suyalatu, Liu, Yingchun, Ye, Chen, Wu, Huiguang, Leppälä, Kalle, Li, Lu, Fang, Lin, Chen, Yujie, Xu, Wenhao, Li, Tao, Liu, Xin, Xu, Xun, Gignoux, Christopher R., Yang, Huanming, Brody, Lawrence C., Wang, Jun, Kristiansen, Karsten, Burenbatu, Burenbatu, Zhou, Huanmin, and Yin, Ye

Published
2018
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58. Genetic Ancestry-Smoking Interactions and Lung Function in African Americans: A Cohort Study

Author

Aldrich, Melinda C, Kumar, Rajesh, Colangelo, Laura A, Williams, L Keoki, Sen, Saunak, Kritchevsky, Stephen B, Meibohm, Bernd, Galanter, Joshua, Hu, Donglei, Gignoux, Christopher R, Liu, Yongmei, Harris, Tamara B, Ziv, Elad, Zmuda, Joseph, Garcia, Melissa, Leak, Tennille S, Foreman, Marilyn G, Smith, Lewis J, Fornage, Myriam, Liu, Kiang, and Burchard, Esteban G

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Tobacco, Minority Health, Lung, Clinical Research, Tobacco Smoke and Health, Respiratory, Cardiovascular, Good Health and Well Being, Adolescent, Adult, Black or African American, Aged, Cohort Studies, Coronary Artery Disease, Female, Humans, Longitudinal Studies, Lung Diseases, Male, Middle Aged, Models, Genetic, Prospective Studies, Respiratory Function Tests, Risk, Smoking, Health ABC and CARDIA Studies Groups, General Science & Technology
Abstract

BackgroundSmoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans.Methodology/principal findingsWe evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV₁) per pack-year of smoking (-5.7 ml FEV₁/ smoking pack-year) compared with smokers with lower African ancestry (-4.6 ml in FEV₁/ smoking pack-year) (interaction P value  = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV(1) decline in Health ABC and independently replicated in CARDIA.Conclusions/significanceAfrican American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking.

Published
2012

59. Development of a panel of genome-wide ancestry informative markers to study admixture throughout the Americas.

Author

Galanter, Joshua Mark, Fernandez-Lopez, Juan Carlos, Gignoux, Christopher R, Barnholtz-Sloan, Jill, Fernandez-Rozadilla, Ceres, Via, Marc, Hidalgo-Miranda, Alfredo, Contreras, Alejandra V, Figueroa, Laura Uribe, Raska, Paola, Jimenez-Sanchez, Gerardo, Zolezzi, Irma Silva, Torres, Maria, Ponte, Clara Ruiz, Ruiz, Yarimar, Salas, Antonio, Nguyen, Elizabeth, Eng, Celeste, Borjas, Lisbeth, Zabala, William, Barreto, Guillermo, González, Fernando Rondón, Ibarra, Adriana, Taboada, Patricia, Porras, Liliana, Moreno, Fabián, Bigham, Abigail, Gutierrez, Gerardo, Brutsaert, Tom, León-Velarde, Fabiola, Moore, Lorna G, Vargas, Enrique, Cruz, Miguel, Escobedo, Jorge, Rodriguez-Santana, José, Rodriguez-Cintrón, William, Chapela, Rocio, Ford, Jean G, Bustamante, Carlos, Seminara, Daniela, Shriver, Mark, Ziv, Elad, Burchard, Esteban Gonzalez, Haile, Robert, Parra, Esteban, Carracedo, Angel, and LACE Consortium

Subjects
LACE Consortium, Humans, Genetic Markers, Population Dynamics, Genome, Human, African Continental Ancestry Group, American Native Continental Ancestry Group, European Continental Ancestry Group, Latin America, Genome, Human, Genetics, Developmental Biology
Abstract

Most individuals throughout the Americas are admixed descendants of Native American, European, and African ancestors. Complex historical factors have resulted in varying proportions of ancestral contributions between individuals within and among ethnic groups. We developed a panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America. We used genome-wide data from 953 individuals from diverse African, European, and Native American populations to select AIMs optimized for each of the three main continental populations that form the basis of modern Latin American populations. We selected markers on the basis of locus-specific branch length to be informative, well distributed throughout the genome, capable of being genotyped on widely available commercial platforms, and applicable throughout the Americas by minimizing within-continent heterogeneity. We then validated the panel in samples from four admixed populations by comparing ancestry estimates based on the AIMs panel to estimates based on genome-wide association study (GWAS) data. The panel provided balanced discriminatory power among the three ancestral populations and accurate estimates of individual ancestry proportions (R² > 0.9 for ancestral components with significant between-subject variance). Finally, we genotyped samples from 18 populations from Latin America using the AIMs panel and estimated variability in ancestry within and between these populations. This panel and its reference genotype information will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.

Published
2012

60. Heterogeneity in Genetic Admixture across Different Regions of Argentina

Author

Avena, Sergio, Via, Marc, Ziv, Elad, Pérez-Stable, Eliseo J, Gignoux, Christopher R, Dejean, Cristina, Huntsman, Scott, Torres-Mejía, Gabriela, Dutil, Julie, Matta, Jaime L, Beckman, Kenneth, Burchard, Esteban González, Parolin, María Laura, Goicoechea, Alicia, Acreche, Noemí, Boquet, Mariel, Del Carmen Ríos Part, María, Fernández, Vanesa, Rey, Jorge, Stern, Mariana C, Carnese, Raúl F, and Fejerman, Laura

Subjects
Biological Sciences, Genetics, Human Society, Argentina, Chromosome Mapping, Ethnicity, Female, Genetic Variation, Genetics, Population, Genotype, Humans, Male, Racial Groups, General Science & Technology
Abstract

The population of Argentina is the result of the intermixing between several groups, including Indigenous American, European and African populations. Despite the commonly held idea that the population of Argentina is of mostly European origin, multiple studies have shown that this process of admixture had an impact in the entire Argentine population. In the present study we characterized the distribution of Indigenous American, European and African ancestry among individuals from different regions of Argentina and evaluated the level of discrepancy between self-reported grandparental origin and genetic ancestry estimates. A set of 99 autosomal ancestry informative markers (AIMs) was genotyped in a sample of 441 Argentine individuals to estimate genetic ancestry. We used non-parametric tests to evaluate statistical significance. The average ancestry for the Argentine sample overall was 65% European (95%CI: 63-68%), 31% Indigenous American (28-33%) and 4% African (3-4%). We observed statistically significant differences in European ancestry across Argentine regions [Buenos Aires province (BA) 76%, 95%CI: 73-79%; Northeast (NEA) 54%, 95%CI: 49-58%; Northwest (NWA) 33%, 95%CI: 21-41%; South 54%, 95%CI: 49-59%; p

Published
2012

61. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Author

Torgerson, Dara G, Ampleford, Elizabeth J, Chiu, Grace Y, Gauderman, W James, Gignoux, Christopher R, Graves, Penelope E, Himes, Blanca E, Levin, Albert M, Mathias, Rasika A, Hancock, Dana B, Baurley, James W, Eng, Celeste, Stern, Debra A, Celedón, Juan C, Rafaels, Nicholas, Capurso, Daniel, Conti, David V, Roth, Lindsey A, Soto-Quiros, Manuel, Togias, Alkis, Li, Xingnan, Myers, Rachel A, Romieu, Isabelle, Van Den Berg, David J, Hu, Donglei, Hansel, Nadia N, Hernandez, Ryan D, Israel, Elliott, Salam, Muhammad T, Galanter, Joshua, Avila, Pedro C, Avila, Lydiana, Rodriquez-Santana, Jose R, Chapela, Rocio, Rodriguez-Cintron, William, Diette, Gregory B, Adkinson, N Franklin, Abel, Rebekah A, Ross, Kevin D, Shi, Min, Faruque, Mezbah U, Dunston, Georgia M, Watson, Harold R, Mantese, Vito J, Ezurum, Serpil C, Liang, Liming, Ruczinski, Ingo, Ford, Jean G, Huntsman, Scott, Chung, Kian Fan, Vora, Hita, Li, Xia, Calhoun, William J, Castro, Mario, Sienra-Monge, Juan J, del Rio-Navarro, Blanca, Deichmann, Klaus A, Heinzmann, Andrea, Wenzel, Sally E, Busse, William W, Gern, James E, Lemanske, Robert F, Beaty, Terri H, Bleecker, Eugene R, Raby, Benjamin A, Meyers, Deborah A, London, Stephanie J, Mexico City Childhood Asthma Study (MCAAS), Gilliland, Frank D, Children's Health Study (CHS) and HARBORS study, Burchard, Esteban G, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Martinez, Fernando D, Childhood Asthma Research and Education (CARE) Network, Weiss, Scott T, Childhood Asthma Management Program (CAMP), Williams, L Keoki, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Barnes, Kathleen C, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Ober, Carole, and Nicolae, Dan L

Subjects
Mexico City Childhood Asthma Study, Children's Health Study (CHS) and HARBORS study, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments, Childhood Asthma Research and Education (CARE) Network, Childhood Asthma Management Program, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Humans, Asthma, Genetic Predisposition to Disease, Risk, African Americans, European Continental Ancestry Group, Hispanic Americans, Caribbean Region, North America, Genome-Wide Association Study, Genetic Loci, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Genes & Environments, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including individuals of European American, African American or African Caribbean, and Latino ancestry, with replication in an additional 12,649 individuals from the same ethnic groups. We identified five susceptibility loci. Four were at previously reported loci on 17q21, near IL1RL1, TSLP and IL33, but we report for the first time, to our knowledge, that these loci are associated with asthma risk in three ethnic groups. In addition, we identified a new asthma susceptibility locus at PYHIN1, with the association being specific to individuals of African descent (P = 3.9 × 10(-9)). These results suggest that some asthma susceptibility loci are robust to differences in ancestry when sufficiently large samples sizes are investigated, and that ancestry-specific associations also contribute to the complex genetic architecture of asthma.

Published
2011

62. Admixture Mapping of Peripheral Artery Disease in a Dominican Population Reveals a Novel Risk Locus on 2q35

Author

Cullina, Sinead, primary, Wojcik, Genevieve L., additional, Shemirani, Ruhollah, additional, Klarin, Derek, additional, Gorman, Bryan R., additional, Sorokin, Elena P., additional, Gignoux, Christopher R., additional, Belbin, Gillian M., additional, Pyarajan, Saiju, additional, Asgari, Samira, additional, Tsao, Phil S., additional, Damrauer, Scott M., additional, Abul-Husn, Noura S., additional, and Kenny, Eimear E., additional

Published
2023
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63. Assessing efficiency of fine-mapping obesity associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB Cohorts

Author

Anwar, Mohammad Yaser, primary, Graff, Mariaelisa, additional, Highland, Heather M., additional, Smit, Roelof, additional, Wang, Zhe, additional, Buchanan, Victoria L., additional, Young, Kristina L., additional, Kenny, Eimear E., additional, Fernandez-Rhodes, Lindsay, additional, Liu, Simin, additional, Assimes, Themistocles, additional, Garcia, David O., additional, Daeeun, Kim, additional, Gignoux, Christopher R., additional, Justice, Anne E., additional, Haiman, Christopher A., additional, Buyske, Steve, additional, Peters, Ulrike, additional, Loos, Ruth, additional, Kooperberg, Charles, additional, and North, Kari E., additional

Published
2023
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65. COVID-19 Mortality in the Colorado Center for Personalized Medicine Biobank

Author

Brice, Amanda N., primary, Vanderlinden, Lauren A., additional, Marker, Katie M., additional, Mayer, David, additional, Lin, Meng, additional, Rafaels, Nicholas, additional, Shortt, Jonathan A., additional, Romero, Alex, additional, Lowery, Jan T., additional, Gignoux, Christopher R., additional, and Johnson, Randi K., additional

Published
2023
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66. Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Author

Wang, Ying, primary, Namba, Shinichi, additional, Lopera, Esteban, additional, Kerminen, Sini, additional, Tsuo, Kristin, additional, Läll, Kristi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Wu, Kuan-Han, additional, Favé, Marie-Julie, additional, Bhatta, Laxmi, additional, Awadalla, Philip, additional, Brumpton, Ben, additional, Deelen, Patrick, additional, Hveem, Kristian, additional, Lo Faro, Valeria, additional, Mägi, Reedik, additional, Murakami, Yoshinori, additional, Sanna, Serena, additional, Smoller, Jordan W., additional, Uzunovic, Jasmina, additional, Wolford, Brooke N., additional, Willer, Cristen, additional, Gamazon, Eric R., additional, Cox, Nancy J., additional, Surakka, Ida, additional, Okada, Yukinori, additional, Martin, Alicia R., additional, Hirbo, Jibril, additional, Wu, Kuan-Han H., additional, Rasheed, Humaira, additional, Hirbo, Jibril B., additional, Wang, Ying, additional, Bhattacharya, Arjun, additional, Zhao, Huiling, additional, Lopera-Maya, Esteban A., additional, Chapman, Sinéad B., additional, Karjalainen, Juha, additional, Kurki, Mitja, additional, Mutaamba, Maasha, additional, Partanen, Juulia J., additional, Brumpton, Ben M., additional, Chavan, Sameer, additional, Chen, Tzu-Ting, additional, Daya, Michelle, additional, Ding, Yi, additional, Feng, Yen-Chen A., additional, Gignoux, Christopher R., additional, Graham, Sarah E., additional, Hornsby, Whitney E., additional, Ingold, Nathan, additional, Johnson, Ruth, additional, Laisk, Triin, additional, Lin, Kuang, additional, Lv, Jun, additional, Millwood, Iona Y., additional, Palta, Priit, additional, Pandit, Anita, additional, Preuss, Michael H., additional, Thorsteinsdottir, Unnur, additional, Zawistowski, Matthew, additional, Zhong, Xue, additional, Campbell, Archie, additional, Crooks, Kristy, additional, de Bock, Geertruida H., additional, Douville, Nicholas J., additional, Finer, Sarah, additional, Fritsche, Lars G., additional, Griffiths, Christopher J., additional, Guo, Yu, additional, Hunt, Karen A., additional, Konuma, Takahiro, additional, Marioni, Riccardo E., additional, Nomdo, Jansonius, additional, Patil, Snehal, additional, Rafaels, Nicholas, additional, Richmond, Anne, additional, Shortt, Jonathan A., additional, Straub, Peter, additional, Tao, Ran, additional, Vanderwerff, Brett, additional, Barnes, Kathleen C., additional, Boezen, Marike, additional, Chen, Zhengming, additional, Chen, Chia-Yen, additional, Cho, Judy, additional, Smith, George Davey, additional, Finucane, Hilary K., additional, Franke, Lude, additional, Ganna, Andrea, additional, Gaunt, Tom R., additional, Ge, Tian, additional, Huang, Hailiang, additional, Huffman, Jennifer, additional, Koskela, Jukka T., additional, Lajonchere, Clara, additional, Law, Matthew H., additional, Li, Liming, additional, Lindgren, Cecilia M., additional, Loos, Ruth J.F., additional, MacGregor, Stuart, additional, Matsuda, Koichi, additional, Olsen, Catherine M., additional, Porteous, David J., additional, Shavit, Jordan A., additional, Snieder, Harold, additional, Trembath, Richard C., additional, Vonk, Judith M., additional, Whiteman, David, additional, Wicks, Stephen J., additional, Wijmenga, Cisca, additional, Wright, John, additional, Zheng, Jie, additional, Zhou, Xiang, additional, Boehnke, Michael, additional, Geschwind, Daniel H., additional, Hayward, Caroline, additional, Kenny, Eimear E., additional, Lin, Yen-Feng, additional, Martin, Hilary C., additional, Medland, Sarah E., additional, Palotie, Aarno V., additional, Pasaniuc, Bogdan, additional, Stefansson, Kari, additional, van Heel, David A., additional, Walters, Robin G., additional, Zöllner, Sebastian, additional, Willer, Cristen J., additional, Daly, Mark J., additional, and Neale, Benjamin M., additional

Published
2023
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67. Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

Author

Zhou, Wei, Kanai, Masahiro, Wu, Kuan-Han H, Rasheed, Humaira, Tsuo, Kristin, Hirbo, Jibril B, Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Namba, Shinichi, Surakka, Ida, Wolford, Brooke N, Lo Faro, Valeria, Lopera-Maya, Esteban A, Läll, Kristi, Favé, Marie-Julie, Partanen, Juulia J, Chapman, Sinéad B, Karjalainen, Juha, Kurki, Mitja, Maasha, Mutaamba, Brumpton, Ben M, Chavan, Sameer, Chen, Tzu-Ting, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A, Guare, Lindsay A, Gignoux, Christopher R, Graham, Sarah E, Hornsby, Whitney E, Ingold, Nathan, Ismail, Said I, Johnson, Ruth, Laisk, Triin, Lin, Kuang, Lv, Jun, Millwood, Iona Y, Moreno-Grau, Sonia, Nam, Kisung, Palta, Priit, Pandit, Anita, Preuss, Michael H, Saad, Chadi, Setia-Verma, Shefali, Thorsteinsdottir, Unnur, Uzunovic, Jasmina, Verma, Anurag, Zawistowski, Matthew, Zhong, Xue, Afifi, Nahla, Al-Dabhani, Kawthar M, Al Thani, Asma, Bradford, Yuki, Campbell, Archie, Crooks, Kristy, De Bock, Geertruida H, Damrauer, Scott M, Douville, Nicholas J, Finer, Sarah, Fritsche, Lars G, Fthenou, Eleni, Gonzalez-Arroyo, Gilberto, Griffiths, Christopher J, Guo, Yu, Hunt, Karen A, Ioannidis, Alexander, Jansonius, Nomdo M, Konuma, Takahiro, Lee, Ming Ta Michael, Lopez-Pineda, Arturo, Matsuda, Yuta, Marioni, Riccardo E, Moatamed, Babak, Nava-Aguilar, Marco A, Numakura, Kensuke, Patil, Snehal, Rafaels, Nicholas, Richmond, Anne, Rojas-Muñoz, Agustin, Shortt, Jonathan A, Straub, Peter, Tao, Ran, Vanderwerff, Brett, Vernekar, Manvi, Veturi, Yogasudha, Barnes, Kathleen C, Boezen, Marike, Chen, Zhengming, Chen, Chia-Yen, Cho, Judy, Smith, George Davey, Finucane, Hilary K, Franke, Lude, Gamazon, Eric R, Ganna, Andrea, Gaunt, Tom R, Ge, Tian, Huang, Hailiang, Huffman, Jennifer, Katsanis, Nicholas, Koskela, Jukka T, Lajonchere, Clara, Law, Matthew H, Li, Liming, Lindgren, Cecilia M, Loos, Ruth JF, MacGregor, Stuart, Matsuda, Koichi, Olsen, Catherine M, Porteous, David J, Shavit, Jordan A, Snieder, Harold, Takano, Tomohiro, Trembath, Richard C, Vonk, Judith M, Whiteman, David C, Wicks, Stephen J, Wijmenga, Cisca, Wright, John, Zheng, Jie, Zhou, Xiang, Awadalla, Philip, Boehnke, Michael, Bustamante, Carlos D, Cox, Nancy J, Fatumo, Segun, Geschwind, Daniel H, Hayward, Caroline, Hveem, Kristian, Kenny, Eimear E, Lee, Seunggeun, Lin, Yen-Feng, Mbarek, Hamdi, Mägi, Reedik, Martin, Hilary C, Medland, Sarah E, Okada, Yukinori, Palotie, Aarno V, Pasaniuc, Bogdan, Rader, Daniel J, Ritchie, Marylyn D, Sanna, Serena, Smoller, Jordan W, Stefansson, Kari, Van Heel, David A, Walters, Robin G, Zöllner, Sebastian, Biobank Of The Americas, Biobank Japan Project, BioMe, BioVU, CanPath-Ontario Health Study, China Kadoorie Biobank Collaborative Group, Colorado Center For Personalized Medicine, DeCODE Genetics, Estonian Biobank, FinnGen, Generation Scotland, Genes & Health Research Team, LifeLines, Mass General Brigham Biobank, Michigan Genomics Initiative, National Biobank Of Korea, Penn Medicine BioBank, Qatar Biobank, QSkin Sun And Health Study, Taiwan Biobank, HUNT Study, UCLA ATLAS Community Health Initiative, Uganda Genome Resource, UK Biobank, Martin, Alicia R, Willer, Cristen J, Daly, Mark J, Neale, Benjamin M, Namba, Shinichi [0000-0002-7486-3146], Guare, Lindsay A [0000-0001-6988-5319], Palta, Priit [0000-0001-9320-7008], de Bock, Geertruida H [0000-0003-3104-4471], Finer, Sarah [0000-0002-2684-4653], Jansonius, Nomdo M [0000-0002-6495-6568], Rojas-Muñoz, Agustin [0000-0001-7594-0599], Gamazon, Eric R [0000-0003-4204-8734], Ganna, Andrea [0000-0002-8147-240X], Koskela, Jukka T [0000-0002-0154-7222], MacGregor, Stuart [0000-0001-6731-8142], Palotie, Aarno V [0000-0002-2527-5874], and Apollo - University of Cambridge Repository

Subjects
biobank, meta-analysis, genetic association studies, GWAS, ancestry diversity, phenotype harmonization
Abstract

Funder: Biogen, Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.

Published
2023
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69. Phylodynamics of a regional SARS-CoV-2 rapid spreading event in Colorado in late 2020

Author

Wade, Kristen J., primary, Tisa, Samantha, additional, Barrington, Chloe, additional, Henriksen, Jesslyn C., additional, Crooks, Kristy R., additional, Gignoux, Christopher R., additional, Almand, Austin T., additional, Steel, J. Jordan, additional, Sitko, John C., additional, Rohrer, Joseph W., additional, Wickert, Douglas P., additional, Almand, Erin A., additional, Pollock, David D., additional, and Rissland, Olivia S., additional

Published
2022
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71. A community driven GWAS summary statistics standard

Author

Hayhurst, James, primary, Buniello, Annalisa, additional, Harris, Laura, additional, Mosaku, Abayomi, additional, Chang, Christopher, additional, Gignoux, Christopher R., additional, Hatzikotoulas, Konstantinos, additional, Karim, Mohd Anisul, additional, Lambert, Samuel A., additional, Lyon, Matt, additional, McMahon, Aoife, additional, Okada, Yukinori, additional, Pirastu, Nicola, additional, Rayner, N. William, additional, Schwartzentruber, Jeremy, additional, Vaughan, Robert, additional, Verma, Shefali, additional, Wilder, Steven P., additional, Cunningham, Fiona, additional, Hindorff, Lucia, additional, Wiley, Ken, additional, Parkinson, Helen, additional, and Barroso, Inês, additional

Published
2022
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72. Nationwide genomic biobank in Mexico unravels demographic history and complex trait architecture from 6,057 individuals

Author

Sohail, Mashaal, primary, Chong, Amanda Y, additional, Quinto-Cortes, Consuelo D, additional, Palma-Martinez, Maria J, additional, Ragsdale, Aaron, additional, Medina-Munoz, Santiago G, additional, Barberena-Jonas, Carmina, additional, Delgado-Sanchez, Guadalupe, additional, Cruz-Hervert, Luis Pablo, additional, Ferreyra-Reyes, Leticia, additional, Ferreira-Guerrero, Elizabeth, additional, Mongua-Rodriguez, Norma, additional, Jimenez-Kaufmann, Andres, additional, Moreno-Macias, Hortensia, additional, Aguilar-Salinas, Carlos A, additional, Auckland, Kathryn, additional, Cortes, Adrian, additional, Acuna-Alonzo, Victor, additional, Ioannidis, Alexander G, additional, Gignoux, Christopher R, additional, Wojcik, Genevieve L, additional, Fernandez-Valverde, Selene L, additional, Hill, Adrian V.S., additional, Tusie-Luna, Maria Teresa, additional, Mentzer, Alexander J, additional, Novembre, John, additional, Garcia-Garcia, Lourdes, additional, and Moreno-Estrada, Andres, additional

Published
2022
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73. Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

Author

Fairhurst-Hunter, Zammy, primary, Lin, Kuang, additional, Millwood, Iona Y, additional, Pozarickij, Alfred, additional, Chen, Tzu-Ting, additional, Torres, Jason M, additional, Luan, Jian-an, additional, Kartsonaki, Christiana, additional, Gan, Wei, additional, Mahajan, Anubha, additional, Du, Huaidong, additional, Sohoni, Rajani, additional, Guo, Yu, additional, Sansome, Sam, additional, Yang, Ling, additional, Yu, Canqing, additional, Chen, Yiping, additional, Lv, Jun, additional, Hemani, Gibran, additional, Koido, Masaru, additional, Kamatani, Yoichiro, additional, Spracklen, Cassandra N, additional, Gordon-Larsen, Penny, additional, Koprulu, Mine, additional, Meng, Xiangrui, additional, Kuchenbaecker, Karoline, additional, Fatumo, Segun, additional, Bhatta, Laxmi, additional, Brumpton, Ben, additional, Alegre-Diaz, Jesus, additional, Kuri-Morales, Pablo, additional, Tapia-Conyer, Roberto, additional, Graham, Sarah E, additional, Willer, Cristen J, additional, Neville, Matt J, additional, Karpe, Fredrik, additional, Graff, Mariaelisa, additional, North, Kari E., additional, Loos, Ruth J.F., additional, Haiman, Christopher A., additional, Peters, Ulrike, additional, Buskye, Steve, additional, Gignoux, Christopher R., additional, Wojcik, Genevieve, additional, Lin, Yen-Feng, additional, Li, Liming, additional, McCarthy, Mark I, additional, Chen, Zhengming, additional, Holmes, Michael V, additional, and Walters, Robin G, additional

Published
2022
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74. Building a Vertically-Integrated Genomic Learning Health System: The Colorado Center for Personalized Medicine Biobank

Author

Wiley, Laura K, primary, Shortt, Jonathan A, additional, Roberts, Emily R, additional, Lowery, Jan, additional, Kudron, Elizabeth, additional, Lin, Meng, additional, Mayer, David A, additional, Wilson, Melissa P, additional, Brunetti, Tonya M, additional, Chavan, Sameer, additional, Phang, Tzu L, additional, Pozdeyev, Nikita, additional, Lesny, Joseph, additional, Wicks, Stephen J, additional, Moore, Ethan, additional, Morgenstern, Joshua L, additional, Roff, Alanna N, additional, Shalowitz, Elise L, additional, Stewart, Adrian, additional, Williams, Cole, additional, Edelmann, Michelle N, additional, Hull, Madelyne, additional, Patton, J. Tacker, additional, Axell, Lisen, additional, Ku, Lisa, additional, Lee, Yee Ming, additional, Jirikowic, Jean, additional, Tanaka, Anna, additional, Todd, Emily, additional, White, Sarah, additional, Peterson, Brett, additional, Hearst, Emily, additional, Zane, Richard, additional, Greene, Casey S, additional, Mathias, Rasika, additional, Coors, Marilyn, additional, Taylor, Matthew RG, additional, Ghosh, Debashis, additional, Kahn, Michael G, additional, Brooks, Ian M, additional, Aquilante, Christina L, additional, Kao, David, additional, Rafaels, Nicholas, additional, Crooks, Kristy, additional, Hess, Steve, additional, Barnes, Kathleen C, additional, and Gignoux, Christopher R, additional

Published
2022
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76. Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits

Author

Highland, Heather M., primary, Wojcik, Genevieve L., additional, Graff, Mariaelisa, additional, Nishimura, Katherine K., additional, Hodonsky, Chani J., additional, Baldassari, Antoine R., additional, Cote, Alanna C., additional, Cheng, Iona, additional, Gignoux, Christopher R., additional, Tao, Ran, additional, Li, Yuqing, additional, Boerwinkle, Eric, additional, Fornage, Myriam, additional, Haessler, Jeffrey, additional, Hindorff, Lucia A., additional, Hu, Yao, additional, Justice, Anne E., additional, Lin, Bridget M., additional, Lin, Danyu, additional, Stram, Daniel O., additional, Haiman, Christopher A., additional, Kooperberg, Charles, additional, Le Marchand, Loic, additional, Matise, Tara C., additional, Kenny, Eimear E., additional, Carlson, Christopher S., additional, Stahl, Eli A., additional, Avery, Christy L., additional, North, Kari E., additional, Ambite, Jose Luis, additional, Buyske, Steven, additional, Loos, Ruth J., additional, Peters, Ulrike, additional, Young, Kristin L., additional, Bien, Stephanie A., additional, and Huckins, Laura M., additional

Published
2022
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78. Disentangling Signatures of Selection Before and After European Colonization in Latin Americans

Author

Mendoza-Revilla, Javier, primary, Chacón-Duque, J. Camilo, additional, Fuentes-Guajardo, Macarena, additional, Ormond, Louise, additional, Wang, Ke, additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Barquera, Rodrigo, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Silva de Cerqueira, Caio C., additional, Badillo Rivera, Keyla M., additional, Nieves-Colón, Maria A., additional, Gignoux, Christopher R., additional, Wojcik, Genevieve L., additional, Moreno-Estrada, Andrés, additional, Hünemeier, Tábita, additional, Ramallo, Virginia, additional, Schuler-Faccini, Lavinia, additional, Gonzalez-José, Rolando, additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Balding, David, additional, Fumagalli, Matteo, additional, Adhikari, Kaustubh, additional, Ruiz-Linares, Andrés, additional, and Hellenthal, Garrett, additional

Published
2022
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80. Allele imputation for the killer cell immunoglobulin-like receptor KIR3DL1/S1

Author

Harrison, Genelle F., primary, Leaton, Laura Ann, additional, Harrison, Erica A., additional, Kichula, Katherine M., additional, Viken, Marte K., additional, Shortt, Jonathan, additional, Gignoux, Christopher R., additional, Lie, Benedicte A., additional, Vukcevic, Damjan, additional, Leslie, Stephen, additional, and Norman, Paul J., additional

Published
2022
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84. Hunter-gatherer genomic diversity suggests a southern African origin for modern humans

Author

Henn, Brenna M., Gignoux, Christopher R., Jobin, Matthew, Granka, Julie M., Macpherson, J. M., Kidd, Jeffrey M., Rodríguez-Botigué, Laura, Ramachandran, Sohini, Hon, Lawrence, Brisbin, Abra, Lin, Alice A., Underhill, Peter A., Comas, David, Kidd, Kenneth K., Norman, Paul J., Parham, Peter, Bustamante, Carlos D., Mountain, Joanna L., Feldman, Marcus W., and King, Mary-Claire

Published
2011

85. Disentangling signatures of selection before and after European colonization in Latin Americans

Author

Mendoza-Revilla, Javier, primary, Chacón-Duque, Juan Camilo, additional, Fuentes-Guajardo, Macarena, additional, Ormond, Louise, additional, Wang, Ke, additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Lozano, Rodrigo Barquera, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Silva de Cerqueira, Caio C., additional, Badillo Rivera, Keyla M., additional, Nieves-Colón, Maria A., additional, Gignoux, Christopher R., additional, Wojcik, Genevieve L., additional, Moreno-Estrada, Andrés, additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Schuler-Faccini, Lavinia, additional, Gonzalez-José, Rolando, additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Balding, David, additional, Fumagalli, Matteo, additional, Adhikari, Kaustubh, additional, Ruiz-Linares, Andrés, additional, and Hellenthal, Garrett, additional

Published
2021
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86. Leveraging health systems data to characterize a large effect variant conferring risk for liver disease in Puerto Ricans

Author

Belbin, Gillian M., primary, Rutledge, Stephanie, additional, Dodatko, Tetyana, additional, Cullina, Sinead, additional, Turchin, Michael C., additional, Kohli, Sumita, additional, Torre, Denis, additional, Yee, Muh-Ching, additional, Gignoux, Christopher R., additional, Abul-Husn, Noura S., additional, Houten, Sander M., additional, and Kenny, Eimear E., additional

Published
2021
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88. A global reference for human genetic variation

Author

Altshuler, David M., (Co-Chair), Durbin, Richard M., (Co-Chair, Principal Investigator), Donnelly, Peter, Green, Eric D., Nickerson, Deborah A., Boerwinkle, Eric, Doddapaneni, Harsha, Han, Yi, Korchina, Viktoriya, Kovar, Christie, Lee, Sandra, Muzny, Donna, Reid, Jeffrey G., Zhu, Yiming, Wang, Jun, (Principal Investigator), Chang, Yuqi, Feng, Qiang, Fang, Xiaodong, Guo, Xiaosen, Jian, Min, Jiang, Hui, Jin, Xin, Lan, Tianming, Li, Guoqing, Li, Jingxiang, Li, Yingrui, Liu, Shengmao, Liu, Xiao, Lu, Yao, Ma, Xuedi, Tang, Meifang, Wang, Bo, Wang, Guangbiao, Wu, Honglong, Wu, Renhua, Xu, Xun, Yin, Ye, Zhang, Dandan, Zhang, Wenwei, Zhao, Jiao, Zhao, Meiru, Zheng, Xiaole, Lander, Eric S., (Principal Investigator), Gabriel, Stacey B., (Co-Chair), Gupta, Namrata, Gharani, Neda, Toji, Lorraine H., Gerry, Norman P., Resch, Alissa M., Barker, Jonathan, Gil, Laurent, Hunt, Sarah E., Kelman, Gavin, Kulesha, Eugene, Leinonen, Rasko, McLaren, William M., Radhakrishnan, Rajesh, Roa, Asier, Smirnov, Dmitriy, Smith, Richard E., Streeter, Ian, Thormann, Anja, Toneva, Iliana, Vaughan, Brendan, Zheng-Bradley, Xiangqun, Bentley, David R., (Principal Investigator), Grocock, Russell, Humphray, Sean, James, Terena, Kingsbury, Zoya, Lehrach, Hans, (Principal Investigator), Sudbrak, Ralf, (Project Leader), Albrecht, Marcus W., Amstislavskiy, Vyacheslav S., Borodina, Tatiana A., Lienhard, Matthias, Mertes, Florian, Sultan, Marc, Timmermann, Bernd, Yaspo, Marie-Laure, Mardis, Elaine R., (Co-Principal Investigator) (Co-Chair), Wilson, Richard K., (Co-Principal Investigator), Fulton, Lucinda, Fulton, Robert, Ananiev, Victor, Belaia, Zinaida, Beloslyudtsev, Dimitriy, Bouk, Nathan, Chen, Chao, Church, Deanna, Cohen, Robert, Cook, Charles, Garner, John, Hefferon, Timothy, Kimelman, Mikhail, Liu, Chunlei, Lopez, John, Meric, Peter, O’Sullivan, Chris, Ostapchuk, Yuri, Phan, Lon, Ponomarov, Sergiy, Schneider, Valerie, Shekhtman, Eugene, Sirotkin, Karl, Slotta, Douglas, Zhang, Hua, Balasubramaniam, Senduran, Burton, John, Danecek, Petr, Keane, Thomas M., Kolb-Kokocinski, Anja, McCarthy, Shane, Stalker, James, Quail, Michael, Schmidt, Jeanette P., (Principal Investigator), Davies, Christopher J., Gollub, Jeremy, Webster, Teresa, Wong, Brant, Zhan, Yiping, Auton, Adam, (Principal Investigator), Campbell, Christopher L., Kong, Yu, Marcketta, Anthony, Yu, Fuli, (Project Leader), Antunes, Lilian, Bainbridge, Matthew, Sabo, Aniko, Huang, Zhuoyi, Coin, Lachlan J. M., Fang, Lin, Li, Qibin, Li, Zhenyu, Lin, Haoxiang, Liu, Binghang, Luo, Ruibang, Shao, Haojing, Xie, Yinlong, Ye, Chen, Yu, Chang, Zhang, Fan, Zheng, Hancheng, Zhu, Hongmei, Alkan, Can, Dal, Elif, Kahveci, Fatma, Garrison, Erik P., (Project Lead), Kural, Deniz, Lee, Wan-Ping, Leong, Wen Fung, Stromberg, Michael, Ward, Alistair N., Wu, Jiantao, Zhang, Mengyao, Daly, Mark J., (Principal Investigator), DePristo, Mark A., (Project Leader), Handsaker, Robert E., (Project Leader), Banks, Eric, Bhatia, Gaurav, del Angel, Guillermo, Genovese, Giulio, Li, Heng, Kashin, Seva, Nemesh, James C., Poplin, Ryan E., Yoon, Seungtai C., (Principal Investigator), Lihm, Jayon, Makarov, Vladimir, Clark, Andrew G., (Principal Investigator), Gottipati, Srikanth, Keinan, Alon, Rodriguez-Flores, Juan L., Rausch, Tobias, (Project Leader), Fritz, Markus H., Stütz, Adrian M., Beal, Kathryn, Datta, Avik, Herrero, Javier, Ritchie, Graham R. S., Zerbino, Daniel, Sabeti, Pardis C., (Principal Investigator), Shlyakhter, Ilya, Schaffner, Stephen F., Vitti, Joseph, Cooper, David N., (Principal Investigator), Ball, Edward V., Stenson, Peter D., Barnes, Bret, Bauer, Markus, Cheetham, Keira R., Cox, Anthony, Eberle, Michael, Kahn, Scott, Murray, Lisa, Peden, John, Shaw, Richard, Kenny, Eimear E., (Principal Investigator), Batzer, Mark A., (Principal Investigator), Konkel, Miriam K., Walker, Jerilyn A., MacArthur, Daniel G., (Principal Investigator), Lek, Monkol, Herwig, Ralf, Koboldt, Daniel C., Larson, David, Ye, Kai, Gravel, Simon, Swaroop, Anand, Chew, Emily, Lappalainen, Tuuli, (Principal Investigator), Erlich, Yaniv, (Principal Investigator), Gymrek, Melissa, Willems, Thomas Frederick, Simpson, Jared T., Shriver, Mark D., (Principal Investigator), Rosenfeld, Jeffrey A., (Principal Investigator), Montgomery, Stephen B., (Principal Investigator), De La Vega, Francisco M., (Principal Investigator), Byrnes, Jake K., Carroll, Andrew W., DeGorter, Marianne K., Lacroute, Phil, Maples, Brian K., Martin, Alicia R., Moreno-Estrada, Andres, Shringarpure, Suyash S., Zakharia, Fouad, Halperin, Eran, (Principal Investigator), Baran, Yael, Cerveira, Eliza, Hwang, Jaeho, Malhotra, Ankit, (Co-Project Lead), Plewczynski, Dariusz, Radew, Kamen, Romanovitch, Mallory, Zhang, Chengsheng, (Co-Project Lead), Hyland, Fiona C. L., Craig, David W., (Principal Investigator), Christoforides, Alexis, Homer, Nils, Izatt, Tyler, Kurdoglu, Ahmet A., Sinari, Shripad A., Squire, Kevin, Xiao, Chunlin, Sebat, Jonathan, (Principal Investigator), Antaki, Danny, Gujral, Madhusudan, Noor, Amina, Ye, Kenny, Burchard, Esteban G., (Principal Investigator), Hernandez, Ryan D., (Principal Investigator), Gignoux, Christopher R., Haussler, David, (Principal Investigator), Katzman, Sol J., Kent, James W., Howie, Bryan, Ruiz-Linares, Andres, (Principal Investigator), Dermitzakis, Emmanouil T., (Principal Investigator), Devine, Scott E., (Principal Investigator), Abecasis, Gonçalo R., (Principal Investigator) (Co-Chair), Kang, Hyun Min, (Project Leader), Kidd, Jeffrey M., (Principal Investigator), Blackwell, Tom, Caron, Sean, Chen, Wei, Emery, Sarah, Fritsche, Lars, Fuchsberger, Christian, Jun, Goo, Li, Bingshan, Lyons, Robert, Scheller, Chris, Sidore, Carlo, Song, Shiya, Sliwerska, Elzbieta, Taliun, Daniel, Tan, Adrian, Welch, Ryan, Wing, Mary Kate, Zhan, Xiaowei, Awadalla, Philip, (Principal Investigator), Hodgkinson, Alan, Li, Yun, Shi, Xinghua, (Principal Investigator), Quitadamo, Andrew, Lunter, Gerton, (Principal Investigator), McVean, Gil A., (Principal Investigator) (Co-Chair), Marchini, Jonathan L., (Principal Investigator), Myers, Simon, (Principal Investigator), Churchhouse, Claire, Delaneau, Olivier, Gupta-Hinch, Anjali, Kretzschmar, Warren, Iqbal, Zamin, Mathieson, Iain, Menelaou, Androniki, Rimmer, Andy, Xifara, Dionysia K., Oleksyk, Taras K., (Principal Investigator), Fu, Yunxin, (Principal Investigator), Liu, Xiaoming, Xiong, Momiao, Jorde, Lynn, (Principal Investigator), Witherspoon, David, Xing, Jinchuan, Browning, Brian L., (Principal Investigator), Browning, Sharon R., (Principal Investigator), Hormozdiari, Fereydoun, Sudmant, Peter H., Khurana, Ekta, (Principal Investigator), Hurles, Matthew E., (Principal Investigator), Albers, Cornelis A., Ayub, Qasim, Chen, Yuan, Colonna, Vincenza, Jostins, Luke, Walter, Klaudia, Xue, Yali, Abyzov, Alexej, Balasubramanian, Suganthi, Chen, Jieming, Clarke, Declan, Fu, Yao, Harmanci, Arif O., Jin, Mike, Lee, Donghoon, Liu, Jeremy, Mu, Xinmeng Jasmine, Zhang, Jing, Zhang, Yan, McCarroll, Steven A., (Principal Investigator), Hartl, Chris, Shakir, Khalid, Degenhardt, Jeremiah, Korbel, Jan O., (Principal Investigator) (Co-Chair), Meiers, Sascha, Raeder, Benjamin, Casale, Francesco Paolo, Stegle, Oliver, Lameijer, Eric-Wubbo, Ding, Li, (Principal Investigator), Hall, Ira, Lee, Charles, (Principal Investigator) (Co-Chair), Bafna, Vineet, Michaelson, Jacob, Gardner, Eugene J., (Project Leader), Mills, Ryan E., (Principal Investigator), Dayama, Gargi, Chen, Ken, (Principle Investigator), Fan, Xian, Chong, Zechen, Chen, Tenghui, Eichler, Evan E., (Principal Investigator) (Co-Chair), Chaisson, Mark J., Huddleston, John, Malig, Maika, Nelson, Bradley J., Parrish, Nicholas F., Blackburne, Ben, Lindsay, Sarah J., Ning, Zemin, Zhang, Yujun, Lam, Hugo, Sisu, Cristina, Gibbs, Richard A., (Principal Investigator) (Co-Chair), Challis, Danny, Evani, Uday S., Lu, James, Nagaswamy, Uma, Yu, Jin, Li, Wangshen, Marth, Gabor T., (Principal Investigator) (Co-Chair), Habegger, Lukas, Yu, Haiyuan, (Principal Investigator), Cunningham, Fiona, Dunham, Ian, Lage, Kasper, (Principal Investigator), Jespersen, Jakob Berg, Horn, Heiko, Tyler-Smith, Chris, (Principal Investigator) (Co-Chair), Gerstein, Mark B., (Principal Investigator) (Co-Chair), Kim, Donghoon, Desalle, Rob, Narechania, Apurva, Wilson Sayres, Melissa A., Bustamante, Carlos D., (Principal Investigator) (Co-Chair), Mendez, Fernando L., Poznik, David G., Underhill, Peter A., Coin, Lachlan, (Principal Investigator), Mittelman, David, Banerjee, Ruby, Cerezo, Maria, Fitzgerald, Thomas W., Louzada, Sandra, Massaia, Andrea, Ritchie, Graham R., Yang, Fengtang, Kalra, Divya, Hale, Walker, Dan, Xu, Flicek, Paul, (Principal Investigator) (Co-Chair), Clarke, Laura, (Project Lead), Sherry, Stephen T., (Principal Investigator) (Co-Chair), Chakravarti, Aravinda, (Co-Chair), Knoppers, Bartha M., (Co-Chair), Barnes, Kathleen C., Beiswanger, Christine, Cai, Hongyu, Cao, Hongzhi, Henn, Brenna, Jones, Danielle, Kaye, Jane S., Kent, Alastair, Kerasidou, Angeliki, Mathias, Rasika, Ossorio, Pilar N., Parker, Michael, Rotimi, Charles N., Royal, Charmaine D., Sandoval, Karla, Su, Yeyang, Tian, Zhongming, Tishkoff, Sarah, Via, Marc, Wang, Yuhong, Yang, Ling, Zhu, Jiayong, Bodmer, Walter, Bedoya, Gabriel, Cai, Zhiming, Gao, Yang, Chu, Jiayou, Peltonen, Leena, Garcia-Montero, Andres, Orfao, Alberto, Dutil, Julie, Martinez-Cruzado, Juan C., Mathias, Rasika A., Hennis, Anselm, Watson, Harold, McKenzie, Colin, Qadri, Firdausi, LaRocque, Regina, Deng, Xiaoyan, Asogun, Danny, Folarin, Onikepe, Happi, Christian, Omoniwa, Omonwunmi, Stremlau, Matt, Tariyal, Ridhi, Jallow, Muminatou, Joof, Fatoumatta Sisay, Corrah, Tumani, Rockett, Kirk, Kwiatkowski, Dominic, Kooner, Jaspal, Hiê`n, Trâ`n Tinh, Dunstan, Sarah J., Hang, Nguyen Thuy, Fonnie, Richard, Garry, Robert, Kanneh, Lansana, Moses, Lina, Schieffelin, John, Grant, Donald S., Gallo, Carla, Poletti, Giovanni, Saleheen, Danish, Rasheed, Asif, Brooks, Lisa D., Felsenfeld, Adam L., McEwen, Jean E., Vaydylevich, Yekaterina, Duncanson, Audrey, Dunn, Michael, Schloss, Jeffery A., and Yang, Huanming

Published
2015
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90. Gene expression in African Americans and Latinos reveals ancestry-specific patterns of genetic architecture

Author

Kachuri, Linda, primary, Mak, Angel C.Y., additional, Hu, Donglei, additional, Eng, Celeste, additional, Huntsman, Scott, additional, Elhawary, Jennifer R., additional, Gupta, Namrata, additional, Gabriel, Stacey, additional, Xiao, Shujie, additional, Keys, Kevin L., additional, Oni-Orisan, Akinyemi, additional, Rodríguez-Santana, José R., additional, LeNoir, Michael, additional, Borrell, Luisa N., additional, Zaitlen, Noah A., additional, Williams, L. Keoki, additional, Gignoux, Christopher R., additional, Burchard, Esteban González, additional, and Ziv, Elad, additional

Published
2021
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91. Selecting Clustering Algorithms for IBD Mapping

Author

Shemirani, Ruhollah, primary, Belbin, Gillian M, additional, Burghardt, Keith, additional, Lerman, Kristina, additional, Avery, Christy L, additional, Kenny, Eimear E, additional, Gignoux, Christopher R, additional, and Ambite, José Luis, additional

Published
2021
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92. Summix: A method for detecting and adjusting for population structure in genetic summary data

Author

Arriaga-MacKenzie, Ian S., primary, Matesi, Gregory, additional, Chen, Samuel, additional, Ronco, Alexandria, additional, Marker, Katie M., additional, Hall, Jordan R., additional, Scherenberg, Ryan, additional, Khajeh-Sharafabadi, Mobin, additional, Wu, Yinfei, additional, Gignoux, Christopher R., additional, Null, Megan, additional, and Hendricks, Audrey E., additional

Published
2021
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94. Clotting factor genes are associated with preeclampsia in high altitude pregnant women in the Peruvian Andes

Author

Badillo Rivera, Keyla M., primary, Nieves-Colón, Maria A., additional, Mendoza, Karla Sandoval, additional, Dávalos, Vanessa Villanueva, additional, Enriquez Lencinas, Luis E., additional, Chen, Jessica W., additional, Zhang, Elisa T., additional, Sockell, Alexandra, additional, Tello, Patricia Ortiz, additional, Hurtado, Gloria Malena, additional, Salas, Ramiro Condori, additional, Cebrecos, Ricardo, additional, Manzaneda Choque, José C., additional, Manzaneda Choque, Franz P., additional, Yábar Pilco, Germán P., additional, Rawls, Erin, additional, Eng, Celeste, additional, Huntsman, Scott, additional, Burchard, Esteban González, additional, Poletti, Giovanni, additional, Gallo, Carla, additional, Bustamante, Carlos D., additional, Baker, Julie C., additional, Gignoux, Christopher R., additional, Wojcik, Genevieve L., additional, and Moreno-Estrada, Andrés, additional

Published
2021
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98. Toward a fine-scale population health monitoring system

Author

Belbin, Gillian M., primary, Cullina, Sinead, additional, Wenric, Stephane, additional, Soper, Emily R., additional, Glicksberg, Benjamin S., additional, Torre, Denis, additional, Moscati, Arden, additional, Wojcik, Genevieve L., additional, Shemirani, Ruhollah, additional, Beckmann, Noam D., additional, Cohain, Ariella, additional, Sorokin, Elena P., additional, Park, Danny S., additional, Ambite, Jose-Luis, additional, Ellis, Steve, additional, Auton, Adam, additional, Bottinger, Erwin P., additional, Cho, Judy H., additional, Loos, Ruth J.F., additional, Abul-Husn, Noura S., additional, Zaitlen, Noah A., additional, Gignoux, Christopher R., additional, and Kenny, Eimear E., additional

Published
2021
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99. HUMAN GENETICS: The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

Author

Moreno-Estrada, Andrés, Gignoux, Christopher R., Fernández-López, Juan Carlos, Zakharia, Fouad, Sikora, Martin, Contreras, Alejandra V., Acuña-Alonzo, Victor, Sandoval, Karla, Eng, Celeste, Romero-Hidalgo, Sandra, Ortiz-Tello, Patricia, Robles, Victoria, Kenny, Eimear E., Nuño-Arana, Ismael, Barquera-Lozano, Rodrigo, Macín-Pérez, Gastón, Granados-Arriola, Julio, Huntsman, Scott, Galanter, Joshua M., Via, Marc, Ford, Jean G., Chapela, Rocío, Rodriguez-Cintron, William, Rodríguez-Santana, Jose R., Romieu, Isabelle, Sienra-Monge, Juan José, del Rio Navarro, Blanca, London, Stephanie J., Ruiz-Linares, Andrés, Garcia-Herrera, Rodrigo, Estrada, Karol, Hidalgo-Miranda, Alfredo, Jimenez-Sanchez, Gerardo, Carnevale, Alessandra, Soberón, Xavier, Canizales-Quinteros, Samuel, Rangel-Villalobos, Hector, Silva-Zolezzi, Irma, Burchard, Esteban Gonzalez, and Bustamante, Carlos D.

Published
2014
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100. Host methylation predicts SARS-CoV-2 infection and clinical outcome

Author

Konigsberg, Iain R., primary, Barnes, Bret, additional, Campbell, Monica, additional, Davidson, Elizabeth, additional, Zhen, Yingfei, additional, Pallisard, Olivia, additional, Boorgula, Meher, additional, Cox, Corey, additional, Nandy, Debmalya, additional, Seal, Souvik, additional, Crooks, Kristy, additional, Sticca, Evan, additional, Harrison, Genelle F., additional, Hopkinson, Andrew, additional, Vest, Alexis, additional, Arnold, Cosby G., additional, Kahn, Michael G., additional, Kao, David P., additional, Peterson, Brett R., additional, Wicks, Stephen J., additional, Ghosh, Debashis, additional, Horvath, Steve, additional, Zhou, Wanding, additional, Mathias, Rasika A., additional, Norman, Paul J., additional, Porecha, Rishi, additional, Yang, Ivana V., additional, Gignoux, Christopher R., additional, Monte, Andrew, additional, Taye, Alem, additional, and Barnes, Kathleen C., additional

Published
2021
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