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51. Reduced Cardiac Index Reserve and Hypovolemia in Severe Falciparum Malaria

Author

Kingston, Hugh W F, primary, Ghose, Aniruddha, primary, Rungpradubvong, Voravut, primary, Satitthummanid, Sudarat, primary, Herdman, M Trent, primary, Plewes, Katherine, primary, Leopold, Stije J, primary, Ishioka, Haruhiko, primary, Mohanty, Sanjib, primary, Maude, Richard J, primary, Schultz, Marcus J, primary, Lagrand, Wim K, primary, Hossain, Md Amir, primary, Day, Nicholas P J, primary, White, Nicholas J, primary, Anstey, Nicholas M, primary, and Dondorp, Arjen M, primary

Published
2019
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52. Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria

Author

Kingston, Hugh W F, primary, Ghose, Aniruddha, additional, Rungpradubvong, Voravut, additional, Satitthummanid, Sudarat, additional, Herdman, M Trent, additional, Plewes, Katherine, additional, Ishioka, Haruhiko, additional, Leopold, Stije J, additional, Sinha, Ipsita, additional, Intharabut, Benjamas, additional, Piera, Kim, additional, McNeil, Yvette, additional, Mohanty, Sanjib, additional, Maude, Richard J, additional, White, Nicholas J, additional, Day, Nicholas P J, additional, Yeo, Tsin W, additional, Hossain, Md Amir, additional, Anstey, Nicholas M, additional, and Dondorp, Arjen M, additional

Published
2019
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53. Temporal trends in severe malaria in Chittagong, Bangladesh

Author

Maude Richard, Hasan Mahtab, Hossain Md, Sayeed Abdullah, Kanti Paul Sanjib, Rahman Waliur, Maude Rapeephan, Vaid Nidhi, Ghose Aniruddha, Amin Robed, Samad Rasheda, Yunus Emran, Rahman M, Bangali Abdul M, Hoque M, Day Nicholas PJ, J White Nicholas, White Lisa J, Dondorp Arjen M, and Faiz M

Subjects
Malaria, Bangladesh, Epidemiology, Incidence, Severe, Falciparum, Vivax, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Epidemiological data on malaria in Bangladesh are sparse, particularly on severe and fatal malaria. This hampers the allocation of healthcare provision in this resource-poor setting. Over 85% of the estimated 150,000-250,000 annual malaria cases in Bangladesh occur in Chittagong Division with 80% in the Chittagong Hill Tracts (CHT). Chittagong Medical College Hospital (CMCH) is the major tertiary referral hospital for severe malaria in Chittagong Division. Methods Malaria screening data from 22,785 inpatients in CMCH from 1999–2011 were analysed to investigate the patterns of referral, temporal trends and geographical distribution of severe malaria in Chittagong Division, Bangladesh. Results From 1999 till 2011, 2,394 malaria cases were admitted, of which 96% harboured Plasmodium falciparum and 4% Plasmodium vivax. Infection was commonest in males (67%) between 15 and 34 years of age. Seasonality of malaria incidence was marked with a single peak in P. falciparum transmission from June to August coinciding with peak rainfall, whereas P. vivax showed an additional peak in February-March possibly representing relapse infections. Since 2007 there has been a substantial decrease in the absolute number of admitted malaria cases. Case fatality in severe malaria was 18% from 2008–2011, remaining steady during this period. A travel history obtained in 226 malaria patients revealed only 33% had been to the CHT in the preceding three weeks. Of all admitted malaria patients, only 9% lived in the CHT, and none in the more remote malaria endemic regions near the Indian border. Conclusions The overall decline in admitted malaria cases to CMCH suggests recent control measures are successful. However, there are no reliable data on the incidence of severe malaria in the CHT, the most endemic area of Bangladesh, and most of these patients do not reach tertiary health facilities. Improvement of early treatment and simple supportive care for severe malaria in remote areas and implementation of a referral system for cases requiring additional supportive care could be important contributors to further reducing malaria-attributable disease and death in Bangladesh.

Published
2012
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54. Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study

Author

Ishioka, Haruhiko, primary, Plewes, Katherine, additional, Pattnaik, Rajyabardhan, additional, Kingston, Hugh W F, additional, Leopold, Stije J, additional, Herdman, M Trent, additional, Mahanta, Kishore, additional, Mohanty, Anita, additional, Dey, Chandan, additional, Alam, Shamsul, additional, Srinamon, Ketsanee, additional, Mohanty, Akshaya, additional, Maude, Richard J, additional, White, Nicholas J, additional, Day, Nicholas P J, additional, Hossain, Md Amir, additional, Faiz, Md Abul, additional, Charunwatthana, Prakaykaew, additional, Mohanty, Sanjib, additional, Ghose, Aniruddha, additional, and Dondorp, Arjen M, additional

Published
2019
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55. Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

Author

Chang, Hsiao-Han, primary, Wesolowski, Amy, additional, Sinha, Ipsita, additional, Jacob, Christopher G, additional, Mahmud, Ayesha, additional, Uddin, Didar, additional, Zaman, Sazid Ibna, additional, Hossain, Md Amir, additional, Faiz, M Abul, additional, Ghose, Aniruddha, additional, Sayeed, Abdullah Abu, additional, Rahman, M Ridwanur, additional, Islam, Akramul, additional, Karim, Mohammad Jahirul, additional, Rezwan, M Kamar, additional, Shamsuzzaman, Abul Khair Mohammad, additional, Jhora, Sanya Tahmina, additional, Aktaruzzaman, M M, additional, Drury, Eleanor, additional, Gonçalves, Sonia, additional, Kekre, Mihir, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Miotto, Olivo, additional, Engø-Monsen, Kenth, additional, Kwiatkowski, Dominic, additional, Maude, Richard J, additional, and Buckee, Caroline, additional

Published
2019
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56. Author response: Mapping imported malaria in Bangladesh using parasite genetic and human mobility data

Author

Chang, Hsiao-Han, primary, Wesolowski, Amy, additional, Sinha, Ipsita, additional, Jacob, Christopher G, additional, Mahmud, Ayesha, additional, Uddin, Didar, additional, Zaman, Sazid Ibna, additional, Hossain, Md Amir, additional, Faiz, M Abul, additional, Ghose, Aniruddha, additional, Sayeed, Abdullah Abu, additional, Rahman, M Ridwanur, additional, Islam, Akramul, additional, Karim, Mohammad Jahirul, additional, Rezwan, M Kamar, additional, Shamsuzzaman, Abul Khair Mohammad, additional, Jhora, Sanya Tahmina, additional, Aktaruzzaman, M M, additional, Drury, Eleanor, additional, Gonçalves, Sonia, additional, Kekre, Mihir, additional, Dhorda, Mehul, additional, Vongpromek, Ranitha, additional, Miotto, Olivo, additional, Engø-Monsen, Kenth, additional, Kwiatkowski, Dominic, additional, Maude, Richard J, additional, and Buckee, Caroline, additional

Published
2019
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57. Gut Microbiota Composition Is Associated with Severity of Disease in Patients with P. Falciparum Malaria

Author

Leopold, Stije, primary, Ghose, Aniruddha, additional, Hugenholtz, Floor, additional, Kingston, Hugh W. F., additional, Plewes, Katherine, additional, Hossain, Amir, additional, Dutta, Asok Kumar, additional, Tarning, Joel, additional, Day, Nicholas P.J., additional, Winterberg, Markus, additional, White, Nicholas J., additional, Vos, Willem M. de, additional, Dondorp, Arjen M., additional, and Wiersinga, W. Joost, additional

Published
2019
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58. Cost to patients and government in the treatment of self-poisoning at a tertiary level hospital in Bangladesh

Author

Verma, Vasundhara R, Paul, Sujat, Ghose, Aniruddha, Eddleston, Michael, and Konradsen, Flemming

Subjects
health care economics and organizations
Abstract

Objectives: Approximately 10,000 people die from suicide annually in Bangladesh, many from pesticide poisoning. We aimed to estimate financial costs to patients and health services of treating patients with self-poisoning.Methods: Data on direct costs to families, sources of funds for treatment and family wealth were collected prospectively over a one-month period in 2016 at the tertiary Chittagong Medical College Hospital, Bangladesh. Aggregate operational costs to the government were calculated using annual budget, bed occupancy and length-of-stay data. Results: Agrochemicals were the most common substances ingested (58.8%). Median durations of stay and of illness were 2 and 5 days, respectively. Median total cost to patients was conservatively estimated at US$98.40, highest in agrochemical poisoning (US$179.50), with the greatest cost due to medicines and equipment. Misdiagnosis as organophosphorus poisoning in 17.0% of agrochemical cases resulted in increased cost to patients. Only 51.9% of patients had indicators of wealth; 78.1% borrowed money to cover costs. Conservatively estimated median healthcare costs (US$21.30 per patient) were markedly lower than costs to patients. Conclusions: Cost to patients of treating a case of agrochemical poisoning was approximately three times the cost of one month’s essential items basket. Incorrect diagnosis at admission cost families substantial sums of money and increased length-of-stay as well as an estimated US$80,428.80 annually to the national government. Widespread access to a list of pesticides used in self-poisoning plus greater focus on training doctors to better manage different forms of agrochemical poisoning should reduce the financial burden to patients and healthcare systems.

Published
2017

59. Identifying the Components of Acidosis in Patients With Severe Plasmodium falciparum Malaria Using Metabolomics

Author

Leopold, Stije J, primary, Ghose, Aniruddha, additional, Allman, Erik L, additional, Kingston, Hugh W F, additional, Hossain, Amir, additional, Dutta, Asok Kumar, additional, Plewes, Katherine, additional, Chotivanich, Kesinee, additional, Day, Nicholas P J, additional, Tarning, Joel, additional, Winterberg, Markus, additional, White, Nicholas J, additional, Llinás, Manuel, additional, and Dondorp, Arjen M, additional

Published
2018
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60. Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study

Author

Leopold, Stije J., primary, Ghose, Aniruddha, additional, Plewes, Katherine A., additional, Mazumder, Subash, additional, Pisani, Luigi, additional, Kingston, Hugh W. F., additional, Paul, Sujat, additional, Barua, Anupam, additional, Sattar, M. Abdus, additional, Huson, Michaëla A. M., additional, Walden, Andrew P., additional, Henwood, Patricia C., additional, Riviello, Elisabeth D., additional, Schultz, Marcus J., additional, Day, Nicholas P. J., additional, Kumar Dutta, Asok, additional, White, Nicholas J., additional, and Dondorp, Arjen M., additional

Published
2018
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62. Short-term glucose dysregulation following acute poisoning with organophosphorus insecticides but not herbicides, carbamate or pyrethroid insecticides in South Asia

Author

Gifford, Robert M., primary, Chathuranga, Umesh, additional, Lamb, Thomas, additional, Verma, Vasundhara, additional, Sattar, Md Abdus, additional, Thompson, Adrian, additional, Siribaddana, Sisira, additional, Ghose, Aniruddha, additional, Forbes, Shareen, additional, Reynolds, Rebecca M., additional, and Eddleston, Michael, additional

Published
2018
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63. Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway

Author

Ye, Weijian, primary, Chew, Marvin, additional, Hou, Jue, additional, Lai, Fritz, additional, Leopold, Stije J., additional, Loo, Hooi Linn, additional, Ghose, Aniruddha, additional, Dutta, Ashok K., additional, Chen, Qingfeng, additional, Ooi, Eng Eong, additional, White, Nicholas J., additional, Dondorp, Arjen M., additional, Preiser, Peter, additional, and Chen, Jianzhu, additional

Published
2018
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64. Reduced Cardiac Index Reserve and Hypovolemia in Severe Falciparum Malaria.

Author

Kingston, Hugh W. F., Ghose, Aniruddha, Rungpradubvong, Voravut, Satitthummanid, Sudarat, Herdman, M. Trent, Plewes, Katherine, Leopold, Stije J., Ishioka, Haruhiko, Mohanty, Sanjib, Maude, Richard J., Schultz, Marcus J., Lagrand, Wim K., Hossain, Md Amir, Day, Nicholas P. J., White, Nicholas J., Anstey, Nicholas M., and Dondorp, Arjen M.

Abstract

Background. Impaired microvascular perfusion is central to the development of coma and lactic acidosis in severe falciparum malaria. Refractory hypotension is rare on admission but develops frequently in fatal cases. We assessed cardiac function and volume status in severe falciparum malaria and its prognostic significance. Methods. Patients with severe (N = 101) or acute uncomplicated falciparum malaria (N = 83) were recruited from 2 hospitals in India and Bangladesh, and healthy participants (N = 44) underwent echocardiography. Results. Patients with severe malaria had 38% shorter left ventricular (LV) filling times and 25% shorter LV ejection times than healthy participants because of tachycardia; however, stroke volume, LV internal diameter in diastole (LVIDd), and LV internal diameter in systole (LVIDs) indices were similar. A low endocardial fraction shortening (eFS) was present in 17% (9 of 52) of severe malaria patients. Adjusting for preload and afterload, eFS was similar in health and severe malaria. Fatal cases had smaller baseline LVIDd and LVIDs indices, more collapsible inferior vena cavae (IVC), and higher heart rates than survivors. The LVIDs and IVC collapsibility were independent predictors for mortality, together with base excess and Glasgow Coma Scale. Conclusions. Patients with severe malaria have rapid ejection of a normal stroke volume. Fatal cases had features of relative hypovolemia and reduced cardiac index reserve. [ABSTRACT FROM AUTHOR]

Published
2020
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65. Associations Between Restrictive Fluid Management and Renal Function and Tissue Perfusion in Adults With Severe Falciparum Malaria: A Prospective Observational Study.

Author

Ishioka, Haruhiko, Plewes, Katherine, Pattnaik, Rajyabardhan, Kingston, Hugh W F, Leopold, Stije J, Herdman, M Trent, Mahanta, Kishore, Mohanty, Anita, Dey, Chandan, Alam, Shamsul, Srinamon, Ketsanee, Mohanty, Akshaya, Maude, Richard J, White, Nicholas J, Day, Nicholas P J, Hossain, Md Amir, Faiz, Md Abul, Charunwatthana, Prakaykaew, Mohanty, Sanjib, and Ghose, Aniruddha

Subjects
MALARIA, LONGITUDINAL method, PERFUSION, HEMORRHAGIC shock, SCIENTIFIC observation, PULMONARY edema, DRUG therapy for malaria, RESEARCH, FLUID therapy, KIDNEY function tests, RESEARCH methodology, EVALUATION research, MEDICAL cooperation, COMPARATIVE studies, RESEARCH funding, LACTIC acid, ACUTE kidney failure
Abstract

Background: Liberal fluid resuscitation has proved harmful in adults with severe malaria, but the level of restriction has not been defined.Methods: In a prospective observational study in adults with severe falciparum malaria, restrictive fluid management was provided at the discretion of the treating physician. The relationships between the volume of fluid and changes in renal function or tissue perfusion were evaluated.Results: A total of 154 patients were studied, 41 (26.6%) of whom died. Median total fluid intake during the first 6 and 24 hours from enrollment was 3.3 (interquartile range [IQR], 1.8-5.1) mL/kg per hour and 2.2 (IQR, 1.6-3.2) mL/kg per hour, respectively. Total fluid intake at 6 hours was not correlated with changes in plasma creatinine at 24 hours (n = 116; rs = 0.16; P = .089) or lactate at 6 hours (n = 94; rs = -0.05; P = .660). Development of hypotensive shock or pulmonary edema within 24 hours after enrollment were not related to the volume of fluid administration.Conclusions: Restrictive fluid management did not worsen kidney function and tissue perfusion in adult patients with severe falciparum malaria. We suggest crystalloid administration of 2-3 mL/kg per hour during the first 24 hours without bolus therapy, unless the patient is hypotensive. [ABSTRACT FROM AUTHOR]

Published
2020
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66. Cell-Free Hemoglobin Is Associated With Increased Vascular Resistance and Reduced Peripheral Perfusion in Severe Malaria.

Author

Kingston, Hugh W F, Ghose, Aniruddha, Rungpradubvong, Voravut, Satitthummanid, Sudarat, Herdman, M Trent, Plewes, Katherine, Ishioka, Haruhiko, Leopold, Stije J, Sinha, Ipsita, Intharabut, Benjamas, Piera, Kim, McNeil, Yvette, Mohanty, Sanjib, Maude, Richard J, White, Nicholas J, Day, Nicholas P J, Yeo, Tsin W, Hossain, Md Amir, Anstey, Nicholas M, and Dondorp, Arjen M

Subjects
*VASCULAR resistance, *MALARIA, *ASYMMETRIC dimethylarginine, *PERFUSION, *HEMOGLOBINS
Abstract

Background: In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon. We hypothesized that low nitric oxide bioavailability due to the presence of cell-free hemoglobin (CFH) increases vascular tone in severe malaria.Methods: Patients with severe malaria (n = 119), uncomplicated malaria (n = 91), or suspected bacterial sepsis (n = 56), as well as healthy participants (n = 50), were recruited. The systemic vascular resistance index (SVRI) was estimated from the echocardiographic cardiac index and the mean arterial pressure.Results: SVRI and hematocrit levels were lower and plasma CFH and asymmetric dimethylarginine levels were higher in patients with malaria, compared with healthy participants. In multivariate linear regression models for mean arterial pressure or SVRI in patients with severe malaria, hematocrit and CFH but not asymmetric dimethylarginine were significant predictors. The SVRI was lower in patients with suspected bacterial sepsis than in those with severe malaria, after adjustment for hematocrit and age. Plasma CFH levels correlated positively with the core-peripheral temperature gradient and plasma lactate levels and inversely with the perfusion index. Impaired peripheral perfusion, as reflected by a low perfusion index or a high core-peripheral temperature gradient, predicted mortality in patients with severe malaria.Conclusions: CFH is associated with mean arterial pressure, SVRI, and peripheral perfusion in patients with severe malaria. This may be mediated through the nitric oxide scavenging potency of CFH, increasing basal vascular tone and impairing tissue perfusion. [ABSTRACT FROM AUTHOR]

Published
2020
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67. The geography of malaria elimination in Bangladesh: combining data layers to estimate the spatial spread of parasites

Author

Chang, Hsiao-Han, primary, Wesolowski, Amy, additional, Sinha, Ipsita, additional, Jacob, Christopher G, additional, Mahmud, Ayesha, additional, Uddin, Didar, additional, Zaman, Sazid Ibna, additional, Hossain, Md Amir, additional, Faiz, M Abul, additional, Ghose, Aniruddha, additional, Sayeed, Abdullah Abu, additional, Rahman, M Ridwanur, additional, Islam, Akramul, additional, Karim, Mohammad Jahirul, additional, Rezwan, M Kamar, additional, Shamsuzzaman, Abul Khair Mohammad, additional, Jhora, Sanya Tahmina, additional, Aktaruzzaman, M M, additional, Miotto, Olivo, additional, Engø-Monsen, Kenth, additional, Kwiatkowski, Dominic, additional, Maude, Richard J, additional, and Buckee, Caroline O, additional

Published
2018
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69. Activation of coagulation and endothelium with concurrent impairment of anticoagulant mechanisms in patients with typhoid fever

Author

de Jong, Hanna K., primary, Parry, Chris M., additional, van der Vaart, Thomas W., additional, Kager, Liesbeth M., additional, van den Ende, Stannie J., additional, Maude, Rapeephan R., additional, Wijedoru, Lalith, additional, Ghose, Aniruddha, additional, Hassan, Mohammed U., additional, Hossain, Mohammed A., additional, Dondorp, Arjan M., additional, Baker, Steve, additional, Faiz, M. Abul, additional, Meijers, Joost C.M., additional, and Wiersinga, W. Joost, additional

Published
2018
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70. Rickettsial Illnesses as Important Causes of Febrile Illness in Chittagong, Bangladesh

Author

Kingston, Hugh W., primary, Hossain, Mosharraf, additional, Leopold, Stije, additional, Anantatat, Tippawan, additional, Tanganuchitcharnchai, Ampai, additional, Sinha, Ipsita, additional, Plewes, Katherine, additional, Maude, Richard J., additional, Chowdhury, M.A. Hassan, additional, Paul, Sujat, additional, Uddin, Rabiul Alam Mohammed Erfan, additional, Siddiqui, Mohammed Abu Naser, additional, Zahed, Abu Shahed, additional, Abu Sayeed, Abdullah, additional, Rahman, Mohammed Habibur, additional, Barua, Anupam, additional, Uddin, Mohammed Jasim, additional, Sattar, Mohammed Abdus, additional, Dondorp, Arjen M., additional, Blacksell, Stuart D., additional, Day, Nicholas P.J., additional, Ghose, Aniruddha, additional, Hossain, Amir, additional, and Paris, Daniel H., additional

Published
2018
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71. Neutrophil extracellular traps in patients with pulmonary tuberculosis

Author

van der Meer, Anne Jan, primary, Zeerleder, Sacha, additional, Blok, Dana C., additional, Kager, Liesbeth M., additional, Lede, Ivar O., additional, Rahman, Wahid, additional, Afroz, Rumana, additional, Ghose, Aniruddha, additional, Visser, Caroline E., additional, Zahed, Abu Shahed Md, additional, Husain, Md Anwar, additional, Alam, Khan Mashrequl, additional, Barua, Pravat Chandra, additional, Hassan, Mahtabuddin, additional, Tayab, Md Abu, additional, Dondorp, Arjen M., additional, and van der Poll, Tom, additional

Published
2017
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72. Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

Author

Näsström, Elin, Parry, Christopher M., Thieu, Nga Tran Vu, Maude, Rapeephan R., de Jong, Hanna K., Fukushima, Masako, Rzhepishevska, Olena, Marks, Florian, Panzner, Ursula, Im, Justin, Jeon, Hyonjin, Park, Seeun, Chaudhury, Zabeen, Ghose, Aniruddha, Samad, Rasheda, Van, Tan Trinh, Johansson, Anders, Dondorp, Arjen M., Thwaites, Guy E., Faiz, Abul, Antti, Henrik, Baker, Stephen, Näsström, Elin, Parry, Christopher M., Thieu, Nga Tran Vu, Maude, Rapeephan R., de Jong, Hanna K., Fukushima, Masako, Rzhepishevska, Olena, Marks, Florian, Panzner, Ursula, Im, Justin, Jeon, Hyonjin, Park, Seeun, Chaudhury, Zabeen, Ghose, Aniruddha, Samad, Rasheda, Van, Tan Trinh, Johansson, Anders, Dondorp, Arjen M., Thwaites, Guy E., Faiz, Abul, Antti, Henrik, and Baker, Stephen

Abstract

Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Nasstrom et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients. After comparing the direction of change and degree of multivariate significance, we identified 24 metabolites that were consistently up- or down regulated in a further Bangladeshi/Senegalese validation cohort, and the Nepali cohort from our previous work. We have identified and validated a metabolite panel that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.

Published
2017
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73. Bites by the Monocled Cobra, Naja kaouthia, in Chittagong Division, Bangladesh : epidemiology, clinical features of envenoming and management of 70 identified cases

Author

Faiz, Mohammad Abul, Ahsan, M. Farid, Ghose, Aniruddha, Rahman, M. Ridwanur, Amin, Robed, Hossain, Moazzem, Tareq, Masud N. U., Jalil, Mohammad Abdul, Kuch, Ulrich, Theakston, R. David G., Warrell, David A., Harris, John B., Faiz, Mohammad Abul, Ahsan, M. Farid, Ghose, Aniruddha, Rahman, M. Ridwanur, Amin, Robed, Hossain, Moazzem, Tareq, Masud N. U., Jalil, Mohammad Abdul, Kuch, Ulrich, Theakston, R. David G., Warrell, David A., and Harris, John B.

Abstract

We describe 70 cases of monocled cobra (Naja kaouthia) bite admitted to Chittagong Medical College Hospital, Bangladesh. The biting snakes were identified by examining the dead snake and/or detecting N. kaouthia venom antigens in patients' serum. Bites were most common in the early morning and evening during the monsoon (May-July). Ligatures were routinely applied to the bitten limb before admission. Thirty-seven patients consulted traditional healers, most of whom made incisions around the bite site. Fifty-eight patients experienced severe neurotoxicity and most suffered swelling and pain of the bitten limb. The use of an Indian polyvalent antivenom in patients exhibiting severe neurotoxicity resulted in clinical improvement but most patients experienced moderate-to-severe adverse reactions. Antivenom did not influence local blistering and necrosis appearing in 19 patients; 12 required debridement. Edrophonium significantly improved the ability of patients to open the eyes, endurance of upward gaze, and peak expiratory flow rate suggesting that a longer-acting anticholinesterase drug (neostigmine) could be recommended for first aid. The study suggested that regionally appropriate antivenom should be raised against the venoms of the major envenoming species of Bangladesh and highlighted the need to improve the training of staff of local medical centers and to invest in the basic health infrastructure in rural communities.

Published
2017

74. Treatment of self-poisoning at a tertiary level hospital in Bangladesh:Cost to patients and government

Author

Verma, Vasundhara, Paul, Sujat, Ghose, Aniruddha, Eddleston, Michael, Konradsen, Flemming, Verma, Vasundhara, Paul, Sujat, Ghose, Aniruddha, Eddleston, Michael, and Konradsen, Flemming

Abstract

OBJECTIVES: Approximately 10,000 people die from suicide annually in Bangladesh, many from pesticide poisoning. We aimed to estimate financial costs to patients and health services of treating patients with self-poisoning.METHODS: Data on direct costs to families, sources of funds for treatment and family wealth were collected prospectively over a one-month period in 2016 at the tertiary Chittagong Medical College Hospital, Bangladesh. Aggregate operational costs to the government were calculated using annual budget, bed occupancy and length-of-stay data.RESULTS: Agrochemicals were the most common substances ingested (58(.) 8%). Median durations of stay and of illness were 2 and 5 days, respectively. Median total cost to patients was conservatively estimated at US$ 98(.) 40, highest in agrochemical poisoning (US$ 179(.) 50), with the greatest cost due to medicines and equipment. Misdiagnosis as organophosphorus poisoning in 17(.) 0% of agrochemical cases resulted in increased cost to patients. Only 51(.) 9% of patients had indicators of wealth; 78(.) 1% borrowed money to cover costs. Conservatively estimated median healthcare costs (US$ 21(.) 30 per patient) were markedly lower than costs to patients.CONCLUSIONS: Cost to patients of treating a case of agrochemical poisoning was approximately three times the cost of one month's essential items basket. Incorrect diagnosis at admission cost families substantial sums of money and increased length-of-stay; it cost the national government an estimated US$ 80,428(.) 80 annually. Widespread access to a list of pesticides used in self-poisoning plus greater focus on training doctors to better manage different forms of agrochemical poisoning should reduce the financial burden to patients and healthcare systems. This article is protected by copyright. All rights reserved.

Published
2017

75. International Advisory Board

Author

Akroush, Maisam Waid, Ala’ Al-Heresh, Radwan Al-Majali, Mohammad, Amin, Robed, Andrews, M.A., Bhat, Raghavendra, Bhosle, Deepak, Chauhan, Vivek, Chowdhury, Abdul Jalil, Dalus, D., Ghose, Aniruddha, Gnanathasan, Christeine Ariaranee, Gowda, Ambanna, Kakrani, A.L., Mohan, Alladi, Mukhopadhyay, Jotideb, Prabhu, E., Ravindran, T., Selvam, M.D., and Uthman, I.

Published
2023
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76. Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

Author

Näsström, Elin, primary, Parry, Christopher M, additional, Vu Thieu, Nga Tran, additional, Maude, Rapeephan R, additional, de Jong, Hanna K, additional, Fukushima, Masako, additional, Rzhepishevska, Olena, additional, Marks, Florian, additional, Panzner, Ursula, additional, Im, Justin, additional, Jeon, Hyonjin, additional, Park, Seeun, additional, Chaudhury, Zabeen, additional, Ghose, Aniruddha, additional, Samad, Rasheda, additional, Van, Tan Trinh, additional, Johansson, Anders, additional, Dondorp, Arjen M, additional, Thwaites, Guy E, additional, Faiz, Abul, additional, Antti, Henrik, additional, and Baker, Stephen, additional

Published
2017
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77. Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study

Author

Plewes, Katherine, primary, Kingston, Hugh W.F., additional, Ghose, Aniruddha, additional, Maude, Richard J., additional, Herdman, M. Trent, additional, Leopold, Stije J., additional, Ishioka, Haruhiko, additional, Hasan, Md. Mahtab Uddin, additional, Haider, Md. Shafiul, additional, Alam, Shamsul, additional, Piera, Kim A., additional, Charunwatthana, Prakaykaew, additional, Silamut, Kamolrat, additional, Yeo, Tsin W., additional, Faiz, Md. Abul, additional, Lee, Sue J, additional, Mukaka, Mavuto, additional, Turner, Gareth D.H., additional, Anstey, Nicholas M., additional, Jackson Roberts, L., additional, White, Nicholas J., additional, Day, Nicholas P.J., additional, Hossain, Md. Amir, additional, and Dondorp, Arjen M., additional

Published
2017
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78. Author response: Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa

Author

Näsström, Elin, primary, Parry, Christopher M, additional, Vu Thieu, Nga Tran, additional, Maude, Rapeephan R, additional, de Jong, Hanna K, additional, Fukushima, Masako, additional, Rzhepishevska, Olena, additional, Marks, Florian, additional, Panzner, Ursula, additional, Im, Justin, additional, Jeon, Hyonjin, additional, Park, Seeun, additional, Chaudhury, Zabeen, additional, Ghose, Aniruddha, additional, Samad, Rasheda, additional, Van, Tan Trinh, additional, Johansson, Anders, additional, Dondorp, Arjen M, additional, Thwaites, Guy E, additional, Faiz, Abul, additional, Antti, Henrik, additional, and Baker, Stephen, additional

Published
2017
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79. Genotypic and phenotypic characterization of G6PD deficiency in Bengali adults with severe and uncomplicated malaria

Author

Plewes, Katherine, primary, Soontarawirat, Ingfar, additional, Ghose, Aniruddha, additional, Bancone, Germana, additional, Kingston, Hugh W. F., additional, Herdman, M. Trent, additional, Leopold, Stije J., additional, Ishioka, Haruhiko, additional, Faiz, Md. Abul, additional, Anstey, Nicholas M., additional, Day, Nicholas P. J., additional, Hossain, Md. Amir, additional, Imwong, Mallika, additional, Dondorp, Arjen M., additional, and Woodrow, Charles J., additional

Published
2017
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80. Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria

Author

Jeeyapant, Atthanee, primary, Kingston, Hugh W., additional, Plewes, Katherine, additional, Maude, Richard J., additional, Hanson, Josh, additional, Herdman, M. Trent, additional, Leopold, Stije J., additional, Ngernseng, Thatsanun, additional, Charunwatthana, Prakaykaew, additional, Phu, Nguyen Hoan, additional, Ghose, Aniruddha, additional, Hasan, M. Mahtab Uddin, additional, Fanello, Caterina I., additional, Faiz, Md Abul, additional, Hien, Tran Tinh, additional, Day, Nicholas P. J., additional, White, Nicholas J., additional, and Dondorp, Arjen M., additional

Published
2017
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81. A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh

Author

Maude, Rapeephan R., primary, Ghose, Aniruddha, additional, Samad, Rasheda, additional, de Jong, Hanna K., additional, Fukushima, Masako, additional, Wijedoru, Lalith, additional, Hassan, Mahtab Uddin, additional, Hossain, Md Amir, additional, Karim, Md Rezaul, additional, Sayeed, Abdullah Abu, additional, van den Ende, Stannie, additional, Pal, Sujat, additional, Zahed, A. S. M., additional, Rahman, Wahid, additional, Karnain, Rifat, additional, Islam, Rezina, additional, Tran, Dung Thi Ngoc, additional, Ha, Tuyen Thanh, additional, Pham, Anh Hong, additional, Campbell, James I., additional, van Doorn, H. Rogier, additional, Maude, Richard J., additional, van der Poll, Tom, additional, Wiersinga, W. Joost, additional, Day, Nicholas P. J., additional, Baker, Stephen, additional, Dondorp, Arjen M., additional, Parry, Christopher M., additional, and Faiz, Md Abul, additional

Published
2016
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82. Identifying the Components of Acidosis in Patients With Severe Plasmodium falciparum Malaria Using Metabolomics.

Author

Leopold, Stije J, Ghose, Aniruddha, Allman, Erik L, Kingston, Hugh W F, Hossain, Amir, Dutta, Asok Kumar, Plewes, Katherine, Chotivanich, Kesinee, Day, Nicholas P J, Tarning, Joel, Winterberg, Markus, White, Nicholas J, Llinás, Manuel, and Dondorp, Arjen M

Subjects
*PLASMODIUM falciparum, *MALARIA, *LIQUID chromatography-mass spectrometry, *CLINICAL trial registries, *PARASITE life cycles
Abstract

Background: Acidosis in severe Plasmodium falciparum malaria is associated with high mortality, yet the pathogenesis remains incompletely understood. The aim of this study was to determine the nature and source of metabolic acids contributing to acidosis in patients with severe falciparum malaria.Methods: A prospective observational study was conducted to characterize circulating acids in adults with P. falciparum malaria (n = 107) and healthy controls (n = 45) from Bangladesh using high-resolution liquid chromatography-mass spectrometry metabolomics. Additional in vitro P. falciparum culture studies were performed to determine if parasites release the acids detected in plasma from patients with severe malaria acidosis.Results: We identified previously unmeasured plasma acids strongly associated with acidosis in severe malaria. Metabolomic analysis of P. falciparum parasites in vitro showed no evidence that these acids are released by the parasite during its life cycle. Instead, 10 of the plasma acids could be mapped to a gut microbial origin. Patients with malaria had low L-citrulline levels, a plasma marker indicating reduced gut barrier integrity. Longitudinal data showed the clearance of these newly identified acids was delayed in fatal cases.Conclusions: These data suggest that a compromise in intestinal barrier function may contribute significantly to the pathogenesis of life-threatening acidosis in severe falciparum malaria.Clinical Trials Registration: NCT02451904. [ABSTRACT FROM AUTHOR]

Published
2019
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83. Short-term glucose dysregulation following acute poisoning with organophosphorus insecticides but not herbicides, carbamate or pyrethroid insecticides in South Asia.

Author

Gifford, Robert M., Chathuranga, Umesh, Lamb, Thomas, Verma, Vasundhara, Sattar, Md Abdus, Thompson, Adrian, Siribaddana, Sisira, Ghose, Aniruddha, Forbes, Shareen, Reynolds, Rebecca M., and Eddleston, Michael

Subjects
GLUCOSE, TYPE 2 diabetes, INSULIN resistance, BLOOD sugar, DIABETES
Abstract

Background: Ingestion of organophosphorus (OP) insecticides is associated with acute hyperglycaemia. We conducted a prospective study to determine whether glucose dysregulation on admission associated with ingestion of OP insecticides or other pesticides is sustained to hospital discharge or to 3–12 months later. Methods: We recruited participants to two similar studies performed in parallel in Anuradhapura, Sri Lanka, and Chittagong, Bangladesh, following hospitalisation for OP insecticide, herbicide or other pesticide self-poisoning. Two-hour 75 g oral glucose tolerance testing (OGTT) was performed after recovery from the acute poisoning, at around the time of discharge. In Sri Lanka, a four time-point OGTT for area-under-the-curve (AUC), C-peptide and homeostatic modelling of insulin resistance (HOMA-IR) was undertaken, repeated after 1 year. In Bangladesh, a 2-h OGTT for glucose was undertaken and repeated after 3 months in participants with initial elevated 2-h glucose. We compared glucose homeostasis by poison group and adjusted findings for age, BMI and sex. Findings: Seventy-three Sri Lankan and 151 Bangladeshi participants were recruited. We observed higher mean [SD] fasting (4.91 [0.74] vs. 4.66 [0.46] mmol/L, p =.003) and 2-h glucose (7.94 [2.54] vs. 6.71 [1.90] mmol/L, p <.0001) in OP-poisoned groups than pyrethroid, carbamate, herbicide or 'other poison' groups at discharge from hospital. In Sri Lanka, HOMA-IR, glucose and C-peptide AUC were higher in OP than carbamate or herbicide groups. Adjusted analyses remained significant except for fasting glucose. Follow-up analysis included 92 participants. There was no significant difference in OGTT results between OP-poisoned and other participants at follow-up (mean [SD] 2-h fasting glucose 4.67 [0.92] vs. 4.82 [0.62], p =.352; 2-h glucose 6.96 [2.31] mmol/L vs. 6.27 [1.86] mmol/L, p =.225). Conclusion: We found in this small prospective study that acute OP insecticide poisoning caused acute glucose dysregulation that was sustained to hospital discharge but had recovered by 3–12 months. Acute glucose dysregulation was related to defects in insulin action and secretion. This study did not address long-term risk of diabetes following acute OP insecticide poisoning, but could provide the data for a power calculation for such a study [ABSTRACT FROM AUTHOR]

Published
2019
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85. Severe falciparum malaria treated with artesunate complicated by delayed onset haemolysis and acute kidney injury

Author

Plewes, Katherine, Haider, Md Shafiul, Kingston, Hugh W. F., Yeo, Tsin W., Ghose, Aniruddha, Hossain, Md Amir, Dondorp, Arjen M., Turner, Gareth D.H., Anstey, Nicholas M., Plewes, Katherine, Haider, Md Shafiul, Kingston, Hugh W. F., Yeo, Tsin W., Ghose, Aniruddha, Hossain, Md Amir, Dondorp, Arjen M., Turner, Gareth D.H., and Anstey, Nicholas M.

Abstract

BackgroundSevere falciparum malaria may be complicated by haemolysis after parasite clearance, however the mechanisms remain unclear. Recent reports describe a pattern of delayed onset haemolysis among non-immune travellers with hyperparasitaemia treated with intravenous artesunate, termed post-artesunate delayed haemolysis (PADH). The occurrence and clinical impact of PADH following severe malaria infections in areas of unstable transmission are unknown.CaseA 45-year-old Bangladeshi male was initially admitted to a local hospital with severe falciparum malaria complicated by hyperparasitaemia and treated with intravenous artesunate. Twenty days from his first presentation he was readmitted with delayed onset haemolytic anaemia and acute kidney injury. Multiple blood transfusions and haemodialysis were required. Renal biopsy revealed acute tubular injury and haem pigment nephropathy. His haemoglobin and renal function recovered to baseline after 62 days from his second admission.DiscussionThis case highlights the differential diagnosis of post-malaria delayed onset haemolysis, including the recently described syndrome of post-artemisinin delayed haemolysis. The pathophysiology contributing to acute kidney injury in this patient and the limited treatment options are discussed.ConclusionsThis report describes PADH complicated by acute kidney injury in an adult patient living in a malaria hypoendemic region who subsequently required blood transfusions and haemodialysis. This case emphasizes the importance of routine follow up of haemoglobin and renal function in artesunate-treated patients who have recovered from severe malaria.

Published
2015

86. Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study

Author

Hanson, Josh, Lee, Sue J., Hossain, Amir, Anstey, Nicholas M., Charunwatthana, Prakaykaew, Maude, Richard J., Kingston, Hugh W. F., Mishra, Saroj K., Mohanty, Sanjib, Plewes, Katherine, Piera, Kim A., Hassan, Mahtab U., Ghose, Aniruddha, Faiz, M. Abdul, White, Nicholas J., Day, Nicholas P. J., Dondorp, Arjen M., Hanson, Josh, Lee, Sue J., Hossain, Amir, Anstey, Nicholas M., Charunwatthana, Prakaykaew, Maude, Richard J., Kingston, Hugh W. F., Mishra, Saroj K., Mohanty, Sanjib, Plewes, Katherine, Piera, Kim A., Hassan, Mahtab U., Ghose, Aniruddha, Faiz, M. Abdul, White, Nicholas J., Day, Nicholas P. J., and Dondorp, Arjen M.

Abstract

BackgroundMicrovascular obstruction and endothelial dysfunction have both been linked to tissue hypoperfusion in falciparum malaria, but their relative contributions to the disease’s pathogenesis and outcome are unknown.MethodsMicrovascular blood flow was quantified in adults with severe falciparum malaria on their admission to hospital; plasma biomarkers of endothelial function were measured simultaneously. The relationship between these indices and the patients’ clinical findings and in-hospital course was examined.ResultsMicrovascular obstruction was observed in 119/142 (84 %) patients; a median (interquartile range (IQR)) of 14.9 % (6.6–34.9 %) of capillaries were obstructed in patients that died versus 8.3 % (1.7–26.6 %) in survivors (P = 0.039). The proportion of obstructed capillaries correlated with the estimated parasite biomass (rs = 0.25, P = 0.004) and with plasma lactate (rs = 0.38, P <0.0001), the strongest predictor of death in the series. Plasma angiopoietin-2 (Ang-2) concentrations were markedly elevated suggesting widespread endothelial activation; the median (IQR) Ang-2 concentration was 21.9 ng/mL (13.4–29.4 ng/mL) in patients that died versus 14.9 ng/mL (9.8–29.3 ng/mL) in survivors (P = 0.035). Ang-2 concentrations correlated with estimated parasite biomass (rs = 0.35, P <0.001) and plasma lactate (rs = 0.37, P <0.0001). Microvascular obstruction and Ang-2 concentrations were not significantly correlated with each other (rs = 0.17, P = 0.06), but were independently associated with plasma lactate (P <0.001 and P = 0.002, respectively).ConclusionsMicrovascular obstruction and systemic endothelial activation are independently associated with plasma lactate, the strongest predictor of death in adults with falciparum malaria. This supports the hypothesis that the two processes make an independent contribution to the pathogenesis and clinical manifestations of the disease.

Published
2015

88. Soluble and cell-associated triggering receptor expressed on myeloid cells-1 and -2 in patients with pulmonary tuberculosis

Author

Hoogendijk, Arie J., primary, Blok, Dana C., additional, Garcia Laorden, M. Isabel, additional, Kager, Liesbeth M., additional, Lede, Ivar O., additional, Rahman, Wahid, additional, Afroz, Rumana, additional, Bresser, Paul, additional, van der Zee, Jaring S., additional, Ghose, Aniruddha, additional, Visser, Caroline E., additional, de Jong, Menno D., additional, Zahed, Abu Shahed Md, additional, Husain, Md Anwar, additional, Alam, Khan Mashrequl, additional, Barua, Pravat Chandra, additional, Hassan, Mahtabuddin, additional, Hossain, Ahmed, additional, Tayab, Md Abu, additional, Lutter, Rene, additional, Day, Nick, additional, Dondorp, Arjen M., additional, van't Veer, Cornelis, additional, de Vos, Alex F., additional, and van der Poll, Tom, additional

Published
2015
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89. Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria

Author

Ishioka, Haruhiko, primary, Ghose, Aniruddha, additional, Charunwatthana, Prakaykaew, additional, Maude, Richard, additional, Plewes, Katherine, additional, Kingston, Hugh, additional, Intharabut, Benjamas, additional, Woodrow, Charlie, additional, Chotivanich, Kesinee, additional, Sayeed, Abdullah Abu, additional, Hasan, Mahtab Uddin, additional, Day, Nicholas P., additional, Faiz, Abul, additional, White, Nicholas J., additional, Hossain, Amir, additional, and Dondorp, Arjen M., additional

Published
2015
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90. A Clinico-Epidemiological Study of Poisoning among Commuters: Is There any Substance Abuse?

Author

ERFAN UDDIN, RABIUL ALAM MD., GHOSE, ANIRUDDHA, MAHTAB UDDIN HASSAN, MD., KUCH, ULRICH, DUTTA, ASHOK KUMAR, ZAHED, ABU SAHED MD., TABASSUM, SADIA, and JABED, SYED MOHAMMAD

Subjects
*SUBSTANCE abuse, *MIDDLE class families, *POISONING, *COMMUTERS, *CRANIAL nerves
Abstract

Background: Poisoning among commuters is becoming a major health hazard day by day in Bangladesh. Few studies were done in Bangladesh regarding this problem. The study aims at describing the clinico-epidemiological features of patients with suspected intentional poisoning during travel for robbery. Method: This was a prospective observational study, conducted in medicine department of Chittagong Medical College Hospital, Bangladesh during March 2010 to September 2010. 40 patients were selected. Out of whom, 15 who had GCS < 8 at presentation were selected for urine analysis by detection kits for a few substances in the urine. Detailed demographic data were collected from the informant in a structured case report form. Clinical examination of the patient was done at presentation and urine was collected in selected patients. Routine patient follow-ups were carried out and the outcome was recorded. Results: Victims were males of 31.23±7.6 years age, most of whom were married (80%), and businessmen (40%). Most of them were brought to hospital by their relatives (80%). Their financial loss by the incidence did not exceed 50,000 tk (i.e., 18937 Tk). They were mainly from middle class family, usually poisoned by beverage (55%), food (30%), and inhalation (5%). Most of them presented with unconsciousness (75%), having GCS 10 on average. Their pupils usually remained constricted bilaterally (75%) with intact light reflex in 35% of the cases. There was no papilledema, and cranial nerves were usually intact in those who could be examined (25%). Patients were usually depressed with absent planter reflex (70%) or flexor (30%). Within 2.5 days, most of them could walk without support and could be discharged. There was neither any case fatality reported or any long term disability recorded. Only 7.5% of the patients had substance examined by kit in their urine. Conclusion: We can come to the conclusion that people who carried money on themselves were victimized by the miscreant and they usually used a substance which had a short onset of action and which could sedate people for a short time with depressive neurological findings. [ABSTRACT FROM AUTHOR]

Published
2018

92. Erratum for Parry et al., Clinically and Microbiologically Derived Azithromycin Susceptibility Breakpoints for Salmonella enterica Serovars Typhi and Paratyphi A

Author

Parry, Christopher M., primary, Thieu, Nga Tran Vu, additional, Dolecek, Christiane, additional, Karkey, Abhilasha, additional, Gupta, Ruchi, additional, Turner, Paul, additional, Dance, David, additional, Maude, Rapeephan R., additional, Ha, Vinh, additional, Tran, Chinh Nguyen, additional, Thi, Phuong Le, additional, Be, Bay Pham Van, additional, Phi, La Tran Thi, additional, Ngoc, Rang Nguyen, additional, Ghose, Aniruddha, additional, Dongol, Sabina, additional, Campbell, James I., additional, Thanh, Duy Pham, additional, Thanh, Tuyen Ha, additional, Moore, Catrin E., additional, Sona, Soeng, additional, Gaind, Rajni, additional, Deb, Monorama, additional, Anh, Ho Van, additional, Van, Sach Nguyen, additional, Tinh, Hien Tran, additional, Day, Nicholas P. J., additional, Dondorp, Arjen, additional, Thwaites, Guy, additional, Faiz, Mohamed Abul, additional, Phetsouvanh, Rattanaphone, additional, Newton, Paul, additional, Basnyat, Buddha, additional, Farrar, Jeremy J., additional, and Baker, Stephen, additional

Published
2015
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93. Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study

Author

Hanson, Josh, primary, Lee, Sue J., additional, Hossain, Md Amir, additional, Anstey, Nicholas M., additional, Charunwatthana, Prakaykaew, additional, Maude, Richard J., additional, Kingston, Hugh W. F., additional, Mishra, Saroj K., additional, Mohanty, Sanjib, additional, Plewes, Katherine, additional, Piera, Kim, additional, Hassan, Mahtab U., additional, Ghose, Aniruddha, additional, Faiz, M. Abul, additional, White, Nicholas J., additional, Day, Nicholas P. J., additional, and Dondorp, Arjen M., additional

Published
2015
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94. Clinically and Microbiologically Derived Azithromycin Susceptibility Breakpoints for Salmonella enterica Serovars Typhi and Paratyphi A

Author

Parry, Christopher M., primary, Thieu, Nga Tran Vu, additional, Dolecek, Christiane, additional, Karkey, Abhilasha, additional, Gupta, Ruchi, additional, Turner, Paul, additional, Dance, David, additional, Maude, Rapeephan R., additional, Ha, Vinh, additional, Tran, Chinh Nguyen, additional, Thi, Phuong Le, additional, Be, Bay Pham Van, additional, Phi, La Tran Thi, additional, Ngoc, Rang Nguyen, additional, Ghose, Aniruddha, additional, Dongol, Sabina, additional, Campbell, James I., additional, Thanh, Duy Pham, additional, Thanh, Tuyen Ha, additional, Moore, Catrin E., additional, Sona, Soeng, additional, Gaind, Rajni, additional, Deb, Monorama, additional, Anh, Ho Van, additional, Van, Sach Nguyen, additional, Tinh, Hien Tran, additional, Day, Nicholas P. J., additional, Dondorp, Arjen, additional, Thwaites, Guy, additional, Faiz, Mohamed Abul, additional, Phetsouvanh, Rattanaphone, additional, Newton, Paul, additional, Basnyat, Buddha, additional, Farrar, Jeremy J., additional, and Baker, Stephen, additional

Published
2015
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95. Pulmonary tuberculosis induces a systemic hypercoagulable state

Author

Kager, Liesbeth M., primary, Blok, Dana C., additional, Lede, Ivar O., additional, Rahman, Wahid, additional, Afroz, Rumana, additional, Bresser, Paul, additional, van der Zee, Jaring S., additional, Ghose, Aniruddha, additional, Visser, Caroline E., additional, de Jong, Menno D., additional, Tanck, Michael W., additional, Zahed, Abu Shahed M., additional, Alam, Khan Mashrequl, additional, Hassan, Mahtabuddin, additional, Hossain, Ahmed, additional, Lutter, Rene, additional, Veer, Cornelis van't, additional, Dondorp, Arjen M., additional, Meijers, Joost C.M., additional, and van der Poll, Tom, additional

Published
2015
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96. Expression of inhibitory regulators of innate immunity in patients with active tuberculosis

Author

Blok, Dana C, primary, Kager, Liesbeth M, additional, Hoogendijk, Arie J, additional, Lede, Ivar O, additional, Rahman, Wahid, additional, Afroz, Rumana, additional, Bresser, Paul, additional, van der Zee, Jaring S, additional, Ghose, Aniruddha, additional, Visser, Caroline E, additional, de Jong, Menno D, additional, Zahed, Abu Shahed Md, additional, Husain, Md Anwar, additional, Alam, Khan Mashrequl, additional, Barua, Pravat Chandra, additional, Hassan, Mahtabuddin, additional, Hossain, Ahmed, additional, Tayab, Md Abu, additional, Lutter, Rene, additional, Day, Nick, additional, Dondorp, Arjen M, additional, de Vos, Alex F, additional, van ’t Veer, Cornelis, additional, and van der Poll, Tom, additional

Published
2015
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97. Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria

Author

Plewes, Katherine, Royakkers, Annick, Hanson, Josh, Hasan, Md, Alam, Shamsul, Ghose, Aniruddha, Maude, Richard, Stassen, Pauline, Charunwatthana, Prakaykaew, Lee, Sue, Turner, Gareth, Dondorp, Arjen M., Schultz, Marcus, Plewes, Katherine, Royakkers, Annick, Hanson, Josh, Hasan, Md, Alam, Shamsul, Ghose, Aniruddha, Maude, Richard, Stassen, Pauline, Charunwatthana, Prakaykaew, Lee, Sue, Turner, Gareth, Dondorp, Arjen M., and Schultz, Marcus

Abstract

Background: Acute kidney injury (AKI) complicating severe Plasmodium falciparum malaria occurs in up to 40% of adult patients. The case fatality rate reaches 75% in the absence of renal replacement therapy (RRT). The precise pathophysiology of AKI in falciparum malaria remains unclear. Histopathology shows acute tubular necrosis with localization of host monocytes and parasitized red blood cells in the microvasculature. This study explored the relationship of plasma soluble urokinase-type plasminogen activator receptor (suPAR), as a proxy-measure of mononuclear cell activation, and plasma P. falciparum histidine rich protein 2 (PfHRP2), as a measure of sequestered parasite burden, with AKI in severe malaria.Methods: Admission plasma suPAR and PfHRP2 concentrations were assessed in Bangladeshi adults with severe falciparum malaria (n = 137). Patients were stratified according to AKI severity based on admission creatinine clearance.Results: A total of 106 (77%) patients had AKI; 32 (23%), 42 (31%) and 32 (23%) were classified into ‘mild, ‘moderate’ and ‘severe’ AKI groups, respectively. Plasma suPAR and PfHRP2 concentrations increased with AKI severity (test-fortrend P <0.0001) and correlated with other markers of renal dysfunction. Admission plasma suPAR and PfHRP2 concentrations were higher in patients who later required RRT (P <0.0001 and P = 0.0004, respectively). In a multivariate analysis, both increasing suPAR and PfHRP2 were independently associated with increasing urine neutrophil gelatinase-associated lipocalin concentration, a marker of acute tubular necrosis (β = 16.54 (95% CI 6.36- 26.71) and β = 0.07 (0.02-0.11), respectively).Conclusions: Both sequestered parasite burden and immune activation contribute to the pathogenesis of AKI in severe falciparum malaria.

Published
2014

98. Magnetic resonance imaging of the brain in adults with severe falciparum malaria

Author

Maude, Richard J., Barkhof, Frederik, Hassan, Mahtab, Ghose, Aniruddha, Hossain, Amir, Faiz, M. Abul, Choudhury, Ehsan, Rashid, Rehnuma, Sayeed, Abdullah, Charunwatthana, Prakaykaew, Plewes, Katherine, Kingston, Hugh W. F., Maude, Rapeephan, Silamut, Kamolrat, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., Maude, Richard J., Barkhof, Frederik, Hassan, Mahtab, Ghose, Aniruddha, Hossain, Amir, Faiz, M. Abul, Choudhury, Ehsan, Rashid, Rehnuma, Sayeed, Abdullah, Charunwatthana, Prakaykaew, Plewes, Katherine, Kingston, Hugh W. F., Maude, Rapeephan, Silamut, Kamolrat, Day, Nicholas P. J., White, Nicholas J., and Dondorp, Arjen M.

Abstract

Background: Magnetic resonance imaging (MRI) allows detailed study of structural and functional changes in thebrain in patients with cerebral malaria.Methods: In a prospective observational study in adult Bangladeshi patients with severe falciparum malaria, MRIfindings in the brain were correlated with clinical and laboratory parameters, retinal photography and optic nervesheath diameter (ONSD) ultrasound (a marker of intracranial pressure).Results: Of 43 enrolled patients, 31 (72%) had coma and 12 (28%) died. MRI abnormalities were present in 79%overall with mostly mild changes in a wide range of anatomical sites. There were no differences in MRI findingsbetween patients with cerebral and non-cerebral or fatal and non-fatal disease. Subtle diffuse cerebral swellingwas common (n = 22/43), but mostly without vasogenic oedema or raised intracranial pressure (ONSD). Also seenwere focal extracellular oedema (n = 11/43), cytotoxic oedema (n = 8/23) and mildly raised brain lactate on magneticresonance spectroscopy (n = 5/14). Abnormalities were much less prominent than previously described in Malawianchildren. Retinal whitening was present in 36/43 (84%) patients and was more common and severe in patientswith coma.Conclusion: Cerebral swelling is mild and not specific to coma or death in adult severe falciparum malaria. Thisdiffers markedly from African children. Retinal whitening, reflecting heterogeneous obstruction of the centralnervous system microcirculation by sequestered parasites resulting in small patches of ischemia, is associatedwith coma and this process is likely important in the pathogenesis.

Published
2014

99. Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis.

Author

Ndour, Papa Alioune, Larréché, Sébastien, Mouri, Oussama, Argy, Nicolas, Gay, Frédérick, Roussel, Camille, Jauréguiberry, Stéphane, Perillaud, Claire, Langui, Dominique, Biligui, Sylvestre, Chartrel, Nathalie, Mérens, Audrey, Kendjo, Eric, Ghose, Aniruddha, Hassan, Md. Mahtab Uddin, Hossain, Md. Amir, Kingston, Hugh W. F., Plewes, Katherine, Dondorp, Arjen M., and Danis, Martin

Subjects
DRUG side effects, HEMOLYSIS & hemolysins, MALARIA treatment, ARTEMISININ, ANTIMALARIALS
Abstract

The article discusses the risk of developing post-artesunate delayed hemolysis (PADH) among patients who received artesunate drug, as treatment for malaria. It mentions the use of an optimizedmembrane permeabilization method for determining the risk of PADH among artesunate-treated malaria patients. It also notes on the development of a semiquantitative titration method for early diagnosis.

Published
2017
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100. Serosurveillance of Orientia tsutsugamushi and Rickettsia typhi in Bangladesh

Author

Maude, Rapeephan R., primary, Maude, Richard J., additional, Ghose, Aniruddha, additional, Amin, M. Robed, additional, Islam, M. Belalul, additional, Ali, Mohammad, additional, Bari, M. Shafiqul, additional, Majumder, M. Ishaque, additional, Tanganuchitcharnchai, Ampai, additional, Dondorp, Arjen M., additional, Paris, Daniel H., additional, Bailey, Robin L., additional, Faiz, M. Abul, additional, Blacksell, Stuart D., additional, and Day, Nicholas P. J., additional

Published
2014
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