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A case of malignant mixed müllerian tumor of the uterus with neuroectodermal differentiation is reported. The most notable feature of the tumor was its large component of central nervous system tissue containing both glial and neuronal elements. The islands of neural tissue were admixed with more conventional carcinomatous and sarcomatous elements typically found in tumors of this type. The neuroectodermal component was conspicuous in the residual uterine tumor removed after radiotherapy, but not in the initial biopsy specimens. The patient died after developing local recurrence and distant metastases, which were treated with chemotherapy.

Five cases of glassy cell carcinoma of the uterine cervix were examined by light and electron microscopy. Light microscopic features included areas of large cells with ground glass and granular cytoplasm, distinct borders, prominent stromal inflammation, and lack of apparent squamous or glandular differentiation. Two neoplasms were associated with separate foci of squamous cell carcinoma in situ and one with endocervical adenocarcinoma. Electron microscopy showed a predominant cell type with cytoplasmic filaments, dilated rough endoplasmic reticulum, Golgi complexes, and large nuclei with complex nucleoli. In some cells there were tonofibrils and well developed desmosomes. The neoplasm of one patient showed poorly developed intracellular lumina. These observations were interpreted to indicate that glassy cell carcinoma is associated with and demonstrates both glandular and squamous differentiation. It is, therefore, properly classified as a type of poorly differentiated adenosquamous carcinoma, which likely develops from the subcylindric reserve cell. The results of this experience reaffirms its poor prognosis.