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886 results on '"Geda, Yonas E."'

52. Association of Performance on the Financial Capacity Instrument–Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults

Author

Vassilaki, Maria, primary, Aakre, Jeremiah A., additional, Kremers, Walter K., additional, Mielke, Michelle M., additional, Geda, Yonas E., additional, Machulda, Mary M., additional, Knopman, David S., additional, Vemuri, Prashanthi, additional, Lowe, Val J., additional, Jack, Clifford R., additional, Roberson, Erik D., additional, Gerstenecker, Adam, additional, Martin, Roy C., additional, Kennedy, Richard E., additional, Marson, Daniel C., additional, and Petersen, Ronald C., additional

Published
2022
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53. Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging

Author

Krell‐Roesch, Janina, primary, Rakusa, Martin, additional, Syrjanen, Jeremy A., additional, Harten, Argonde C., additional, Lowe, Val J., additional, Jack, Clifford R., additional, Kremers, Walter K., additional, Knopman, David S., additional, Stokin, Gorazd B., additional, Petersen, Ronald C., additional, Vassilaki, Maria, additional, and Geda, Yonas E., additional

Published
2022
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54. Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials

Author

Mortby, Moyra E., primary, Adler, Lawrence, additional, Agüera-Ortiz, Luis, additional, Bateman, Daniel R., additional, Brodaty, Henry, additional, Cantillon, Marc, additional, Geda, Yonas E., additional, Ismail, Zahinoor, additional, Lanctôt, Krista L., additional, Marshall, Gad A., additional, Padala, Prasad R., additional, Politis, Antonios, additional, Rosenberg, Paul B., additional, Siarkos, Kostas, additional, Sultzer, David L., additional, and Theleritis, Christos, additional

Published
2022
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55. Apathy as a Treatment Target in Alzheimer's Disease: Implications for Clinical Trials

Author

Mortby, Moyra E. Adler, Lawrence Aguera-Ortiz, Luis Bateman, Daniel R. Brodaty, Henry Cantillon, Marc Geda, Yonas E. and Ismail, Zahinoor Lanctot, Krista L. Marshall, Gad A. Padala, Prasad R. Politis, Antonios Rosenberg, Paul B. Siarkos, Kostas Sultzer, David L. Theleritis, Christos Pia, Istaart Nps

Abstract

Apathy is one of the most prevalent, stable and persistent neuropsychiatric symptom across the neurocognitive disorders spectrum. Recent advances in understanding of phenomenology, neurobiology and intervention trials highlight apathy as an important target for clinical intervention. We conducted a comprehensive review and critical evaluation of recent advances to determine the evidence-based suggestions for future trial designs. This review focused on 4 key areas: 1) pre-dementia states; 2) assessment; 3) mechanisms/biomarkers and 4) treatment/intervention efficacy. Considerable progress has been made in understanding apathy as a treatment target and appreciating pharmacological and non-pharmacological apathy treatment interventions. Areas requiring greater investigation include: diagnostic procedures, symptom measurement, understanding the biological mechanisms/biomarkers of apathy, and a well formed approach to the development of treatment strategies. A better under- standing of the subdomains and biological mechanisms of apathy will advance apathy as a treatment target for clinical trials. (Am J Geriatr Psychiatry 2022; 30:119-147)

Published
2022

59. A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment

Author

Pink, Anna, primary, Krell‐Roesch, Janina, additional, Syrjanen, Jeremy A., additional, Vassilaki, Maria, additional, Lowe, Val J., additional, Vemuri, Prashanthi, additional, Stokin, Gorazd B., additional, Christianson, Teresa J., additional, Kremers, Walter K., additional, Jack, Clifford R., additional, Knopman, David S., additional, Petersen, Ronald C., additional, and Geda, Yonas E., additional

Published
2021
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60. Apathy as a treatment target in neurocognitive disorders: Clinical trial implications

Author

Mortby, Moyra E, primary, Adler, Lawrence, additional, Agüera‐Ortiz, Luis, additional, Bateman, Dan R, additional, Brodaty, Henry, additional, Cantillon, Marc, additional, Geda, Yonas E., additional, Ismail, Zahinoor, additional, Lanctôt, Krista L., additional, Marshall, Gad A, additional, Padala, Prasad R, additional, Politis, Antonis, additional, Rosenberg, Paul B., additional, Siarkos, Kostas, additional, Sultzer, David L, additional, and Theleritis, Christos, additional

Published
2021
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61. Abstract 10133: Cerebrovascular Imaging Biomarkers, Neuropsychiatric Symptoms, and Mild Cognitive Impairment

Author

Vassilaki, Maria, primary, Syrjanen, Jeremy, additional, Scharf, Eugene, additional, Krell-Roesch, Janina, additional, Vemuri, Prashanthi, additional, Graff-radford, Jonathan, additional, Mielke, Michelle, additional, Machulda, Mary M., additional, Kremers, Walter, additional, Lowe, Val, additional, Jack, Clifford, additional, Knopman, David, additional, Petersen, Ronald, additional, and Geda, Yonas E., additional

Published
2021
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68. Physiological pattern of cognitive aging

Author

Novotný, Jan S., primary, Gonzalez-Rivas, Juan P., additional, Vassilaki, Maria, additional, Krell-Roesch, Janina, additional, Geda, Yonas E., additional, and Stokin, Gorazd B., additional

Published
2021
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71. A longitudinal investigation of Aβ, anxiety, depression, and mild cognitive impairment.

Author

Pink, Anna, Krell‐Roesch, Janina, Syrjanen, Jeremy A., Vassilaki, Maria, Lowe, Val J., Vemuri, Prashanthi, Stokin, Gorazd B., Christianson, Teresa J., Kremers, Walter K., Jack, Clifford R., Knopman, David S., Petersen, Ronald C., and Geda, Yonas E.

Abstract

Introduction: We investigated the longitudinal relationship between cortical amyloid deposition, anxiety, and depression and the risk of incident mild cognitive impairment (MCI). Methods: We followed 1440 community‐dwelling, cognitively unimpaired individuals aged ≥ 50 years for a median of 5.5 years. Clinical anxiety and depression were assessed using Beck Anxiety and Depression Inventories (BAI, BDI‐II). Cortical amyloid beta (Aβ) was measured by Pittsburgh compound B positron emission tomography (PiB‐PET) and elevated deposition (PiB+) was defined as standardized uptake value ratio ≥ 1.48. We calculated Cox proportional hazards models with age as the time scale, adjusted for sex, education, and medical comorbidity. Results: Cortical Aβ deposition (PiB+) independent of anxiety (BAI ≥ 10) or depression (BDI‐II ≥ 13) increased the risk of MCI. There was a significant additive interaction between PiB+ and anxiety (joint effect hazard ratio 6.77; 95% confidence interval 3.58–12.79; P =.031) that is, being PiB+ and having anxiety further amplified the risk of MCI. Discussion: Anxiety modified the association between PiB+ and incident MCI. [ABSTRACT FROM AUTHOR]

Published
2022
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72. Additional file 1 of Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project

Author

Alosco, Michael L., Mariani, Megan L., Adler, Charles H., Balcer, Laura J., Bernick, Charles, Au, Rhoda, Banks, Sarah J., Barr, William B., Bouix, Sylvain, Cantu, Robert C., Coleman, Michael J., Dodick, David W., Farrer, Lindsay A., Geda, Yonas E., Katz, Douglas I., Koerte, Inga K., Kowall, Neil W., Lin, Alexander P., Marcus, Daniel S., Marek, Kenneth L., McClean, Michael D., McKee, Ann C., Mez, Jesse, Palmisano, Joseph N., Peskind, Elaine R., Tripodis, Yorghos, Turner, Robert W., Wethe, Jennifer V., Cummings, Jeffrey L., Reiman, Eric M., Shenton, Martha E., and Stern, Robert A.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2021
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79. NIA‐AA Alzheimer's Disease Framework: Clinical Characterization of Stages

Author

Petersen, Ronald C., primary, Wiste, Heather J., additional, Weigand, Stephen D., additional, Fields, Julie A., additional, Geda, Yonas E., additional, Graff‐Radford, Jonathan, additional, Knopman, David S., additional, Kremers, Walter K., additional, Lowe, Val, additional, Machulda, Mary M., additional, Mielke, Michelle M., additional, Stricker, Nikki H., additional, Therneau, Terry M., additional, Vemuri, Prashanthi, additional, and Jack, Clifford R., additional

Published
2021
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80. Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging

Author

Krell‐Roesch, Janina, primary, Syrjanen, Jeremy A., additional, Machulda, Mary M., additional, Christianson, Teresa J., additional, Kremers, Walter K., additional, Mielke, Michelle M., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Vassilaki, Maria, additional, and Geda, Yonas E., additional

Published
2021
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81. National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome

Author

Katz, Douglas I., primary, Bernick, Charles, additional, Dodick, David W., additional, Mez, Jesse, additional, Mariani, Megan L., additional, Adler, Charles H., additional, Alosco, Michael L., additional, Balcer, Laura J., additional, Banks, Sarah J., additional, Barr, William B., additional, Brody, David L., additional, Cantu, Robert C., additional, Dams-O'Connor, Kristen, additional, Geda, Yonas E., additional, Jordan, Barry D., additional, McAllister, Thomas W., additional, Peskind, Elaine R., additional, Petersen, Ronald C., additional, Wethe, Jennifer V., additional, Zafonte, Ross D., additional, Foley, Éimear M., additional, Babcock, Debra J., additional, Koroshetz, Walter J., additional, Tripodis, Yorghos, additional, McKee, Ann C., additional, Shenton, Martha E., additional, Cummings, Jeffrey L., additional, Reiman, Eric M., additional, and Stern, Robert A., additional

Published
2021
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83. Prevalence of neuropsychiatric symptoms in mild cognitive impairment and normal cognitive aging: population-based study

Author

Geda, Yonas E., Roberts, Rosebud O., Knopman, David S., Petersen, Ronald C., Christianson, Teresa J.H., Pankratz, Vernon S., Smith, Glenn E., Boeve, Bradley F., IVnik, Robert J., Tangalos, Eric G., and Rocca, Walter A.

Subjects
Neurologic manifestations of general diseases -- Research, Psychological manifestations of general diseases -- Research, Cognition disorders -- Research, Cognition in old age -- Physiological aspects, Cognition in old age -- Research, Health, Psychology and mental health
Published
2008

84. Increased risk of depressive and anxiety disorders in relatives of patients with parkinson disease

Author

Arabia, Gennarina, Grossardt, Brandon R., Geda, Yonas E., Carlin, Justin M., Bower, James H., Ahlskog, J. Eric, Maraganore, Demetrius M., and Rocca, Walter A.

Subjects
Parkinson's disease -- Physiological aspects, Parkinson's disease -- Research, Depression, Mental -- Risk factors, Anxiety -- Risk factors, Disease susceptibility -- Research, Health, Psychology and mental health
Published
2007

86. Perspectives on depression, mild cognitive impairment, and cognitive decline

Author

Steffens, David C., Otey, Emeline, Alexopoulos, George S., Butters, Meryl A., Cuthbert, Bruce, Ganguli, Mary, Geda, Yonas E., Hendrie, Hugh C., Krishnan, Ranga R., Kumar, Anand, Lopez, Oscar L., Lyketsos, Constantine G., Mast, Benjamin T., Morris, John C., Norton, Maria C., Peavy, Guerry M., Petersen, Ronald C., Reynolds, Charles F., Salloway, Stephen, Welsh-Bohmer, Kathleen A., and Yesavage, Jerome

Subjects
Depression in old age -- Research, Cognition disorders in old age -- Research, Health, Psychology and mental health
Published
2006

87. Physical Activity and Trajectory of Cognitive Change in Older Persons: Mayo Clinic Study of Aging

Author

Krell-Roesch, Janina, primary, Syrjanen, Jeremy A., additional, Bezold, Jelena, additional, Trautwein, Sandra, additional, Barisch-Fritz, Bettina, additional, Boes, Klaus, additional, Woll, Alexander, additional, Forzani, Erica, additional, Kremers, Walter K., additional, Machulda, Mary M., additional, Mielke, Michelle M., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Vassilaki, Maria, additional, and Geda, Yonas E., additional

Published
2021
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88. Association of Cortical and Subcortical β-Amyloid With Standardized Measures of Depressive and Anxiety Symptoms in Adults Without Dementia

Author

Krell-Roesch, Janina, primary, Syrjanen, Jeremy A., additional, Rakusa, Martin, additional, Vemuri, Prashanthi, additional, Machulda, Mary M., additional, Kremers, Walter K., additional, Mielke, Michelle M., additional, Lowe, Val J., additional, Jack, Clifford R., additional, Knopman, David S., additional, Stokin, Gorazd B., additional, Petersen, Ronald C., additional, Vassilaki, Maria, additional, and Geda, Yonas E., additional

Published
2021
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89. Investigating cognition in midlife

Author

Novotný, Jan S., primary, Gonzalez‐Rivas, Juan P., additional, Medina‐Inojosa, Jose R., additional, Lopez‐Jimenez, Francisco, additional, Geda, Yonas E., additional, and Stokin, Gorazd B., additional

Published
2021
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91. Association Between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Author

Krell-Roesch, Janina, primary, Syrjanen, Jeremy A., additional, Mielke, Michelle M., additional, Christianson, Teresa J., additional, Kremers, Walter K., additional, Machulda, Mary M., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Vassilaki, Maria, additional, and Geda, Yonas E., additional

Published
2020
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100. Associations between high triglycerides and arterial stiffness in a population-based sample: Results from the Kardiovize 2030 study

Author

Pavlovska, Iuliia, primary, Kunzova, Sarka, additional, Jakubik, Juraj, additional, Hruskova, Jana, additional, Skladana, Maria, additional, Rivas-Serna, Irma Magaly, additional, Medina-Inojosa, Jose R., additional, Lopez-Jimenez, Francisco, additional, Vysoky, Robert, additional, Geda, Yonas E., additional, Stokin, Gorazd B., additional, and González-Rivas, Juan P., additional

Published
2020
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