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Abstract Juvenile papillomatosis (JP) of the breast is a rare benign mass‐forming lesion occurring in young women, which is histologically characterized by a constellation of proliferative changes and large cysts, giving it the gross appearance of Swiss cheese. A subset of patients with JP report a family history of breast carcinoma and/or coexisting or subsequent breast carcinoma. We performed whole‐exome sequencing of the hyperplastic epithelial component of three JPs, including one with coexisting ductal carcinoma in situ (DCIS) and invasive ductal carcinoma of no special type (IDC‐NST). JPs harbored clonal somatic PIK3CA hotspot mutations in two cases. In the JP with coexisting DCIS and IDC‐NST, these lesions were clonally related to the associated JP, sharing a clonal PIK3CA E542K somatic hotspot mutation. JP showed a paucity of copy number alterations, whereas the associated DCIS and IDC‐NST showed concurrent 1q gains/16q losses, hallmarks of estrogen receptor (ER)‐positive breast cancers. We observed JP to harbor a dominant aging‐related mutational signature, whereas coexisting DCIS and IDC‐NST showed greater exposure to an APOBEC signature. Taken together, our findings suggest that, at least in a subset of cases, JP might constitute the substrate from which DCIS and invasive breast carcinomas develop.

Desde el año 2019 se desarrolla en el ámbito de la Facultad de Ciencias Jurídicas y Sociales de la Universidad Nacional del Litoral el Proyecto de Extensión de Interés Social “Acampe por una justicia ecológica”. El mismo considera especialmente la dimensión territorial con miras a identificar desigualdades en el acceso a la justicia en materia ambiental. Para ello y mediante la realización de campamentos jurídicos, se toma contacto con personas que residen en pequeños pueblos y ciudades agrícolas de la provincia de Santa Fe y se analiza el estado de situación de la problemática ambiental y los mecanismos existentes para peticionar en defensa de derechos vulnerados. En esta oportunidad, se aborda la experiencia transcurrida en la localidad de Santo Domingo, ubicada en el departamento Las Colonias. Se relatan las tareas llevadas a cabo y se destacan los resultados obtenidos en las encuestas, entrevistas y actividades realizadas.

Human conditional reasoning is defeasible: people withdrawlogically valid conclusions if they are aware of situations (i.e.,exceptions) that prevent the consequent of the rule to happenalthough the antecedent is given. In this paper we investigatedefeasible reasoning with quantified rules. In two experimentswe rephrased conditionals from the literature (Experiment 1)and rules from penal code (Experiment 2) as either universalor existential rules and embedded them into Modus Ponensand Modus Tollens inference problems. We show that defeasiblereasoning also exists for quantified rules. However, thekind of quantifier (universal vs. existential) did not affect inferences.This last finding conflicts with theories highlightingthe importance of logic in human reasoning.

The aim was to analyze the reliability and validity of a low-cost instrument, based on a radar system, to quantify the kicking ball speed in soccer. A group of 153 male soccer players (under-13, n = 53; under-15, n = 54; under-18, n = 46) participated in this study. Each player performed three kicks on the goal in a standardized condition while the ball speed was measured with three different devices: one Radar Stalker ATS II® (reference criterion) and two Supido Radar® (Supido-front of the goal and Supido-back of the goal). The standard error of measurement (SEM) expressed as a coefficient of variation (CV) and the intraclass correlation coefficient (ICC) were employed for assessing the reliability of each instrument. Stalker and Supido-back showed very high absolute (CV = 4.0–5.4%) and relative (ICC = 0.945–0.958) reliability, whereas Supido-front resulted in moderate to low reliability scores (CV = 7.4–15%, ICC = 0.134–0.693). In addition, Lin’s concordance correlation coefficient (CCC) values revealed an ‘almost perfect’ agreement between Stalker and Supido-back for the average (r = 0.99) and maximal (r = 0.98) ball speed, regardless of the ball speed range analyzed. However, Supido-front resulted in a poor degree of concordance (CCC = 0.688) and a high magnitude of error (17.0–37.5 km·h−1) with the reference Stalker radar gun. The Supido Radar® placed behind the goal could be considered a reliable and valid device for measuring ball speed in soccer.

More than 450 million people worldwide suffer from diabetes, or 1 in 11 people. Chronic hyperglycemia degrades patients’ quality of life and the development of neuropathic pain contributes to the burden of this disease. In this study, we used the mouse model of streptozocin-induced diabetic type 1 neuropathy to assess the analgesic potential of etifoxine. Etifoxine is a prescribed anxiolytic that increases GABAAA receptor function through a direct positive allosteric modulation effect and, indirectly, by stimulating the production of endogenous GABAA receptor positive modulators such as allopregnanolone-type neurosteroids. We show that a post-symptomatic or preventive treatment strongly and durably reduces mechanical hyperalgesia and anxiety in diabetic neuropathic mice. This analgesic and neuroprotective effect on painful symptoms and emotional comorbidities is promising and should now be clinically evaluated.

Abstract Objective To outline the demographic and clinical characteristics of patients with deep intestinal endometriosis submitted to surgical treatment at a tertiary referral center with a multidisciplinary team, and correlate those characteristics with the surgical procedures performed and operative complications. Methods A prospective cohort from February 2012 to November 2016 of 32 women with deep intestinal endometriosis operations. The variables analyzed were: age; obesity; preoperative symptoms (dysmenorrhea, dyspareunia, acyclic pain, dyschezia, infertility, urinary symptoms, constipation and intestinal bleeding); previous surgery for endometriosis; Enzian classification; size of the intestinal lesion; and surgical complications. Results Themean age was 37.75 (±5.72) years. A total of 7 patients (22%) had a prior history of endometriosis. The mean of the largest diameter of the intestinal lesions identified intraoperatively was of 28.12 mm (±14.29 mm). In the Enzian classification, there was a predominance of lesions of the rectum and sigmoid, comprising 30 cases (94%). There were no statistically significant associations between the predictor variables and the outcome complications, even after the multiple logistic regression analysis. Regarding the size of the lesion, there was also no significant correlation with the outcome complications (p = 0.18; 95% confidence interval [95%CI]:0.94-1.44); however, there was a positive association between grade 3 of the Enzia classification and the more extensive surgical techniques: segmental intestinal resection and rectosigmoidectomy, with a prevalence risk of 4.4 (p < 0.001; 95%CI:1.60-12.09). Conclusion The studied sample consisted of highly symptomatic women. A high prevalence of deep infiltrative endometriosis lesions was found located in the rectum and sigmoid region, and their size correlated directly with the extent of the surgical resection performed.

Abstract Objective To evaluate the quality of the sexual function of women with suspected deep infiltrating endometriosis. Methods A cross-sectional, observational and prospective study was conducted between May 2015 and August 2016, in which 67 patients with deep infiltrating endometriosis, suspected or diagnosed, were assessed for epidemiological and clinical characteristics, such as pain level through a visual analog scale (VAS), features of deep infiltrating endometriosis lesions and score on the Female Sexual Function Index (FSFI) before the onset of treatment. The statistical analysis was performed using the software STATA version 12.0 (StataCorp LLC, College Station, TX, USA) to compare the variables through multiple regression analysis. Results The average age of the patients was 39.2 years old; most patients were symptomatic (92.5%); and the predominant location of the deep infiltrating lesions was on the rectosigmoid colon (50%), closely followed by the retrocervical region (48.3%). The medianoverallscoreontheFSFIwas23.4;in67.2%of thecasesthescorewas26.5(cutoff point for sexualdysfunction). Deepdyspareunia(p = 0.000,confidenceinterval [CI]:0.64- 0.83) and rectosigmoid endometriosis lesions (p = 0.008, CI: 0.72-0.95) showed significant correlation with lower FSFI scores, adjusted by bladder lesion, patients’ ageand size of lesions. Deep dyspareunia (p = 0.003, CI: 0.49-0.86) also exhibited significant correlation with FSFI pain domain, adjusted by cyclic bowel pain, vaginal lesion and use of gonadotropin-releasing hormone (GnRH) analog. These results reflect the influence of deep dyspareunia on the sexual dysfunction of the analyzed population. Conclusion Most patients exhibited sexual dysfunction, and deep dyspareunia was the pelvic painful symptom that showed correlation with sexual dysfunction.

The genetic repertoire of primary thyroid cancers (TCs) is well documented, but there is a considerable lack of molecular profiling in metastatic TCs. Here, we retrieved and analyzed the molecular and clinical features of 475 primary and metastatic TCs subjected to targeted DNA sequencing, from the cBioPortal database. The cohort included primary and metastatic samples from 276 papillary thyroid carcinomas (PTCs), 5 follicular thyroid carcinomas, 22 Hürthle cell carcinomas (HCCs), 127 poorly differentiated thyroid carcinomas (PDTCs), 30 anaplastic thyroid carcinomas (ATCs) and 15 medullary thyroid carcinomas. The ATCs had the highest tumor mutational burden and the HCCs the highest fraction of the genome altered. Compared to primary PTCs, the metastases had a significantly higher frequency of genetic alterations affecting TERT (51% vs 77%, P < 0.001), CDKN2A (2% vs 10%, P < 0.01), RET (2% vs 7%, P < 0.05), CDKN2B (1% vs 6%, P < 0.05) and BCOR (0% vs 4%, P < 0.05). The distant metastases had a significantly lower frequency of BRAF (64% vs 85%, P < 0.01) and a significantly higher frequency of NRAS (13% vs 3%, P < 0.05) hotspot mutations than the lymph node metastases. Metastases from HCCs and PDTCs were found to be enriched for NF1 (29%) and TP53 (18%) biallelic alterations, respectively. The frequency of subclonal mutations in ATCs was significantly higher than in PTCs (43% vs 25%, P < 0.01) and PDTCs (43% vs 22%, P < 0.01). Metastatic TCs are enriched in clinically informative genetic alterations such as RET translocations, BRAF hotspot mutations and NF1 biallelic losses that may be explored therapeutically. [ABSTRACT FROM AUTHOR]

Introduction: Warm-up is a primordial element to optimise sport performance in both training and competitions. The main objective of this study was to compare the acute effect of two warm-up protocols for physical and technical-decisional performance in U16 football players. Material and Methods: We applied an integrated warm-up protocol (IWP) of 5 vs 5 in a small space of 20x28 m and an analytical warm-up protocol (AWP) of 12 dynamic exercises that are commonly used in football. Each warm-up was carried out 7 days apart and alternated. After each warm-up, the intensity of the load was recorded through the rate of perceived exertion (RPE), physical performance was recorded using the T30 speed test (time to sprint 30 m) and the kicking speed test, and the Loughborough Soccer Passing Test (LSPT) was applied, which evaluates the football skills of passing and decision making. Results: The results show greater technical-decisional performance in LSPT (p = 0.020, ES = 0.55 small) after executing the IWP. However, in T30 (p = 0.129, ES = 0.417 small) and kicking (p = 0.374, ES = -0.29 small), no significant differences were observed. Conclusion: IWP presents greater performance in the technical-decisional test of LSPT, and both warm-up protocols have a similar component of intensity and performance in T30 and kicking. [ABSTRACT FROM AUTHOR]

(1) Background: An improved understanding of soccer players’ match-related physical performance and recovery may help conditioning programs and re-warm up strategies to increase team performance during official competitions. Therefore, the aim of this study was to analyze the acute effects of 45 min of official competition (first half in matches) on physical performance variables in U-16 youth soccer players. (2) Methods: 20 male soccer players (age: 14.4 ± 0.5 years; height: 1.70 ± 0.05 cm; body mass: 65.1 ± 11.6 kg) were recruited to participate in this study. Data was collected from five official matches. Participants performed the assessments in two stages of each match: after the pre-match warm-up and after the first half. Tests included rate of perceived exertion (RPE), 30-m sprint and countermovement (CMJ). (3) Results: Statistically significant differences were found (p < 0.001) when the measurements prior to the game were compared with those recorded after half time across all variables. Effect sizes (ES) were very large for RPE (ES = 1.82), moderate for 30-m sprint times (ES = 0.64) and small for CMJ (ES = −0.25). (4) Conclusions: After 45 min of official competition, our results suggest that U-16 soccer players demonstrated a reduction in sprint and jump performance, in addition to a higher RPE. Hence, this information could be useful when designing re-warming strategies that can be performed before the second half.