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56. Cerebrospinal fluid analysis and the determination of oligoclonal bands

Author

Gastaldi, M, Zardini, E, Leante, R, Ruggieri, M, Costa, G, Cocco, E, De Luca, G, Cataldo, I, Biagioli, T, Ballerini, C, Castellazzi, M, Fainardi, E, Pettini, P, Zaffaroni, M, Giunti, D, Capello, E, Bernardi, G, Ciusani, E, Giannotta, C, Nobile-Orazio, E, Bazzigaluppi, E, Passerini, G, Bedin, R, Sola, P, Brivio, R, Cavaletti, G, Sala, A, Bertolotto, A, Desina, G, Leone, M, Mariotto, S, Ferrari, S, Paternoster, A, Giavarina, D, Lolli, F, Franciotta, D, Gastaldi M., Zardini E., Leante R., Ruggieri M., Costa G., Cocco E., De Luca G., Cataldo I., Biagioli T., Ballerini C., Castellazzi M., Fainardi E., Pettini P., Zaffaroni M., Giunti D., Capello E., Bernardi G., Ciusani E., Giannotta C., Nobile-Orazio E., Bazzigaluppi E., Passerini G., Bedin R., Sola P., Brivio R., Cavaletti G., Sala A., Bertolotto A., Desina G., Leone M. A., Mariotto S., Ferrari S., Paternoster A., Giavarina D., Lolli F., Franciotta D., Gastaldi, M, Zardini, E, Leante, R, Ruggieri, M, Costa, G, Cocco, E, De Luca, G, Cataldo, I, Biagioli, T, Ballerini, C, Castellazzi, M, Fainardi, E, Pettini, P, Zaffaroni, M, Giunti, D, Capello, E, Bernardi, G, Ciusani, E, Giannotta, C, Nobile-Orazio, E, Bazzigaluppi, E, Passerini, G, Bedin, R, Sola, P, Brivio, R, Cavaletti, G, Sala, A, Bertolotto, A, Desina, G, Leone, M, Mariotto, S, Ferrari, S, Paternoster, A, Giavarina, D, Lolli, F, Franciotta, D, Gastaldi M., Zardini E., Leante R., Ruggieri M., Costa G., Cocco E., De Luca G., Cataldo I., Biagioli T., Ballerini C., Castellazzi M., Fainardi E., Pettini P., Zaffaroni M., Giunti D., Capello E., Bernardi G., Ciusani E., Giannotta C., Nobile-Orazio E., Bazzigaluppi E., Passerini G., Bedin R., Sola P., Brivio R., Cavaletti G., Sala A., Bertolotto A., Desina G., Leone M. A., Mariotto S., Ferrari S., Paternoster A., Giavarina D., Lolli F., and Franciotta D.

Abstract

This document presents the guidelines for the cerebrospinal fluid (CSF) analysis and the determination of oligoclonal bands (OCBs) as pivotal tests in neuroin flammatory pathologies of the central nervous system. The guidelines have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on the pathologies in which the CSF analysis is indicated, and, particularly, on those characterized by the presence of OCBs in the intrathecal compartment, indications and limits of CSF analysis and OCB determination, instructions for result interpretation, and agreed laboratory protocols (Appendix) are reported for the communicative community of neurologists and clinical pathologists.

Published
2017

62. Subgroup comparison according to clinical phenotype and serostatus in autoimmune encephalitis: a multicenter retrospective study

Author

Gastaldi, M, Mariotto, S, Giannoccaro, M P, Iorio, R, Zoccarato, M, Nosadini, M, Benedetti, L, Casagrande, S, Di Filippo, M, Valeriani, M, Ricci, S, Bova, S, Arbasino, C, Mauri, M, Versino, M, Vigevano, F, Papetti, L, Romoli, M, Lapucci, C, Massa, F, Sartori, S, Zuliani, Danilo, Barilaro, Cynthia, De Gaspari, P, Spagni, Gregorio, Evoli Stampanoni-B, Amelia, Liguori, R, Ferrari, S, Marchioni, E, Giometto, B, Massacesi, L, Franciotta, D, Zuliani, L, Barilaro, A (ORCID:0000-0002-6576-8921), Spagni, G, Evoli, A (ORCID:0000-0003-0282-8787), Gastaldi, M, Mariotto, S, Giannoccaro, M P, Iorio, R, Zoccarato, M, Nosadini, M, Benedetti, L, Casagrande, S, Di Filippo, M, Valeriani, M, Ricci, S, Bova, S, Arbasino, C, Mauri, M, Versino, M, Vigevano, F, Papetti, L, Romoli, M, Lapucci, C, Massa, F, Sartori, S, Zuliani, Danilo, Barilaro, Cynthia, De Gaspari, P, Spagni, Gregorio, Evoli Stampanoni-B, Amelia, Liguori, R, Ferrari, S, Marchioni, E, Giometto, B, Massacesi, L, Franciotta, D, Zuliani, L, Barilaro, A (ORCID:0000-0002-6576-8921), Spagni, G, and Evoli, A (ORCID:0000-0003-0282-8787)

Abstract

BACKGROUND AND PURPOSE: Autoimmune encephalitides (AE) include a spectrum of neurological disorders whose diagnosis revolves around the detection of neuronal antibodies (Abs). Consensus-based diagnostic criteria (AE-DC) allow clinic-serological subgrouping of AE, with unclear prognostic implications. The impact of AE-DC on patients' management was studied, focusing on the subgroup of Ab-negative-AE. METHODS: This was a retrospective multicenter study on patients fulfilling AE-DC. All patients underwent Ab testing with commercial cell-based assays (CBAs) and, when available, in-house assays (immunohistochemistry, live/fixed CBAs, neuronal cultures) that contributed to defining final categories. Patients were classified as Ab-positive-AE [N-methyl-d-aspartate-receptor encephalitis (NMDAR-E), Ab-positive limbic encephalitis (LE), definite-AE] or Ab-negative-AE (Ab-negative-LE, probable-AE, possible-AE). RESULTS: Commercial CBAs detected neuronal Abs in 70/118 (59.3%) patients. Testing 37/48 Ab-negative cases, in-house assays identified Abs in 11 patients (29.7%). A hundred and eighteen patients fulfilled the AE-DC, 81 (68.6%) with Ab-positive-AE (Ab-positive-LE, 40; NMDAR-E, 32; definite-AE, nine) and 37 (31.4%) with Ab-negative-AE (Ab-negative-LE, 17; probable/possible-AE, 20). Clinical phenotypes were similar in Ab-positive-LE versus Ab-negative-LE. Twenty-four/118 (20.3%) patients had tumors, and 19/118 (16.1%) relapsed, regardless of being Ab-positive or Ab-negative. Ab-positive-AE patients were treated earlier than Ab-negative-AE patients (P = 0.045), responded more frequently to treatments (92.3% vs. 65.6%, P < 0.001) and received second-line therapies more often (33.3% vs. 10.8%, P = 0.01). Delays in first-line therapy initiation were associated with poor response (P = 0.022; odds ratio 1.02; confidence interval 1.00-1.04). CONCLUSIONS: In-house diagnostics improved Ab detection allowing better patient management but was available in a patient subgro

Published
2019

64. Acquired neuromyotonia in thymoma-associated myasthenia gravis: a clinical and serological study

Author

Gastaldi, M, De Rosa, A, Maestri, M, Zardini, E, Scaranzin, S, Guida, M, Borrelli, P, Ferraro, OE, Lampasona, V, Furlan, R, Irani, SR, Waters, P, Lang, B, Vincent, A, Marchioni, E, Ricciardi, R, and Franciotta, D

Subjects
Adult, Male, neuromyotonia, UNC5A antibodies, myasthenia gravis, Thymoma, Electromyography, autoantibodies, Membrane Proteins, Thymus Neoplasms, Original Articles, Middle Aged, Netrin-1, DCC antibodies, Humans, Female, Original Article, Isaacs Syndrome, paraneoplastic neurological syndrome, Neoplasm Recurrence, Local, Retrospective Studies
Abstract

Background and purpose: Acquired neuromyotonia can occur in patients with thymoma, alone or in association with myasthenia gravis (MG), but the clinical prognostic significance of such comorbidity is largely unknown. The clinico‐pathological features were investigated along with the occurrence of neuromyotonia as predictors of tumour recurrence in patients with thymoma‐associated myasthenia.Methods: A total number of 268 patients with thymomatous MG were studied retrospectively. Patients with symptoms of spontaneous muscle overactivity were selected for autoantibody testing using immunohistology for neuronal cell‐surface proteins and cell‐based assays for contactin‐associated protein 2 (CASPR2), leucine‐rich glioma inactivated 1 (LGI1), glycine receptor and Netrin‐1 receptor antibodies. Neuromyotonia was diagnosed according to the presence of typical electromyography abnormalities and/or autoantibodies against LGI1/CASPR2.Results: Overall, 33/268 (12%) MG patients had a thymoma recurrence. Five/268 (2%) had neuromyotonia, four with typical autoantibodies, including LGI1 (n = 1), CASPR2 (n = 1) or both (n = 2). Three patients had Netrin‐1 receptor antibodies, two with neuromyotonia and concomitant CASPR2+LGI1 antibodies and one with spontaneous muscle overactivity without electromyography evidence of neuromyotonia. Thymoma recurrence was more frequent in those with (4/5, 80%) than in those without (28/263, 10%, P < 0.001) neuromyotonia. Neuromyotonia preceded the recurrence in 4/5 patients. In univariate analysis, predictors of thymoma recurrence were age at thymectomy [odds ratio (OR) 0.95, 95% confidence interval (CI) 0.93–0.97], Masaoka stage ≥IIb (OR 10.73, 95% CI 2.38–48.36) and neuromyotonia (OR 41.78, 95% CI 4.71–370.58).Conclusions: De novo occurrence of neuromyotonia in MG patients with previous thymomas is a rare event and may herald tumour recurrence. Neuronal autoantibodies can be helpful to assess the diagnosis. These observations provide pragmatic risk stratification for tumour vigilance in patients with thymomatous MG.

Published
2018

65. Hadronic Energy Resolution of a Combined High Granularity Scintillator Calorimeter System

Author

Repond, J., Xia, L., Apostolakis, J., Folger, G., Ivantchenko, V., Ribon, A., Uzhinskiy, V., Boumediene, D., Francais, V., Blazey, G. C., Dyshkant, A., Francis, K., Zutshi, V., Bach, O., Brianne, E., Ebrahimi, A., Gadow, K., Göttlicher, Peter, Krivan, Frantisek, Krüger, Katja, Kvasnicka, Jiri, Lu, S., Neubüser, C., Provenza, A., Reinecke, M., Sefkow, F., Schuwalow, S., Sudo, Y., Tran, H. L., Buhmann, P., Garutti, E., Laurien, S., Lomidze, David, Matysek, M., Kaplan, A., Schultz-Coulon, H. -Ch., Wilson, G. W., Jeans, Daniel, Kawagoe, K., Sekiya, Izumi, Suehara, T., Yamashiro, H., Yoshioka, T., Wing, Matthew, Kotera, K., Nishiyama, M., Sakuma, T., Takeshita, T., Tozuka, S., Tubokawa, T., Uozumi, S., Alamillo, E. Calvo, Fouz, M. C., Marin, J., Navarrete, J., Pelayo, J. Puerta, Verdugo, A., Chadeeva, Marina, Danilov, Michael, Drutskoy, A., Popova, Elena, Rusinov, V., Tarkovsky, E., Emberger, Lorenz, Gabriel, Miroslav, Graf, Christian, Israeli, Y., Van Der Kolk, N., Simon, Frank, Szalay, M., Windel, H., Bonis, J., Poeschl, Roman, Irles, Adrián, Thiebault, A., Richard, F., Zerwas, D., Anduze, M., Balagura, V., Becheva, E., Boudry, V., Brient, J-C., Cornat, R., Edy, E., Gastaldi, M. Frotin F., Li, B., Magniette, F., Nanni, J., Rubio-Roy, M., Shpak, K., Tran, Trong Hieu, Videau, H., Cvach, J., Janata, Milan, Kovalcuk, M., Polak, I., Smolik, J., Vrba, V., Zalesak, Jaroslav, Zuklin, J., Chang, S., Khan, A., Kim, D. H., Kong, D. J., Oh, Y. D., Elkhalii, A., Götze, M., Zeitnitz, Christian, Hartbrich, Oskar, and Bilokin, Sviatoslav

Abstract

Journal of Instrumentation 13(12), P12022 (2018). doi:10.1088/1748-0221/13/12/P12022, This paper presents results obtained with the combined CALICE Scintillator Electromagnetic Calorimeter, Analogue Hadronic Calorimeter and Tail Catcher & Muon Tracker, three high granularity scintillator-SiPM calorimeter prototypes. The response of the system to pions with momenta between 4 GeV/c and 32 GeV/c is analysed, including the energy response, resolution, and longitudinal shower profiles. The results of a software compensation technique based on weighting according to hit energy are compared to those of a standard linear energy reconstruction. The results are compared to predictions of the GEANT4 physics lists QGSP_BERT_HP and FTFP_BERT_HP., Published by Inst. of Physics, London

Published
2018
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68. Cerebrospinal fluid kappa and lambda free light chains in oligoclonal band‐negative patients with suspected multiple sclerosis

Author

Ferraro, D., primary, Trovati, A., additional, Bedin, R., additional, Natali, P., additional, Franciotta, D., additional, Santangelo, M., additional, Camera, V., additional, Vitetta, F., additional, Varani, M., additional, Trenti, T., additional, Gastaldi, M., additional, De Biasi, S., additional, Nasi, M., additional, Pinti, M., additional, Meletti, S., additional, and Sola, P., additional

Published
2019
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71. Acquired neuromyotonia in thymoma‐associated myasthenia gravis: a clinical and serological study

Author

Gastaldi, M., primary, De Rosa, A., additional, Maestri, M., additional, Zardini, E., additional, Scaranzin, S., additional, Guida, M., additional, Borrelli, P., additional, Ferraro, O. E., additional, Lampasona, V., additional, Furlan, R., additional, Irani, S. R., additional, Waters, P., additional, Lang, B., additional, Vincent, A., additional, Marchioni, E., additional, Ricciardi, R., additional, and Franciotta, D, additional

Published
2019
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74. Examining the effect of managing GHG emissions on business performance

Author

Capece, G, Di Pillo, F, Gastaldi, M, Levialdi, N, and Miliacca, M

Subjects
Planning and Development, sustainable development, Geography, Monitoring, Policy and Law, greenhouse gas emissions, Strategy and Management1409 Tourism, Leisure and Hospitality Management, ROI, business performance, environmental management system, environmental policy, Business and International Management, Geography, Planning and Development, Strategy and Management1409 Tourism, Leisure and Hospitality Management, Management, Monitoring, Policy and Law, Settore ING-IND/35 - Ingegneria Economico-Gestionale, Management, greenhouse gasemissions
Published
2017

75. Comportamento alla corrosione di armature in calcestruzzo con materie prime contaminate da cloruri-Parte I: prove di laboratorio

Author

Lollini, F., Carsana, M., Gastaldi, M., Redaelli, E., Torabian Isfahani, F., and Bertolini, L.

Subjects
Chlorides, Concrete, Durability, Seawater, Stainless steel bars, Sustainability, sostenibilità, acqua di mare, armature inossidabili, durabilità, cloruri, calcestruzzo, sostenibilità, cloruri, armature inossidabili, durabilità, acqua di mare, calcestruzzo
Published
2017

76. Estimation of corrosion propagation in carbonated reinforced concrete structures by monitoring of the electrical resistivity of concrete [Stima della propagazione della corrosione in strutture in calcestruzzo armato carbonatate attraverso il monitoraggio della resistività del calcestruzzo]

Author

Messina, M., Gastaldi, M., and Bertolini, L.

Subjects
Carbonation-induced corrosion, Corrosion rate, Electrical resistivity of concrete, Monitoring, Condensed Matter Physics, Mechanics of Materials, 2506
Published
2017

79. PREVALENCE OF ANTI-NEUROFASCIN-155, ANTI-CONTACTIN-1 AND CONTACTIN-ASSOCIATED PROTEIN 1 ANTIBODIES IN CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY: A SEROLOGICAL MULTICENTER STUDY IN ITALY

Author

Callegari, I., Cortese, A., Lauria, G., Briani, C., Luigetti, M., Fazio, R., Benedetti, L., Marfia, G., Clerici, M., Carpo, M., Corbo, M., Mazzeo, A., Ferrari, S., Giannini, F., Man-Ganelli, F., Manso, C., Claudia Giannotta, Berardinelli, A., Zardini, E., Romagnolo, S., Curro, R., Gastaldi, M., Spina, E., Topa, A., Dacci, P., Lombardi, R., Campagnolo, M., Bisogni, G., Cerri, F., De, Michelis C., Mataluni, G., Stancanelli, C., Mariotto, S., Piccolo, L., Schenone, A., Moglia, A., Marchioni, E., Nobile-Orazio, E., Devaux, J., and Franciotta, D.

Subjects
Settore MED/26 - Neurologia
Published
2017

80. Clinical, demographic and laboratory data associated with PML risk in patients treated with natalizumab

Author

Toboso, I., Alvarez-Lafuente, R., Arroyo, R., Hegen, H., Deisenhammer, F., Sainz La Maza, S., Izquierdo, G., Paramo, D., Oliva, P., Casanova, B., Aguera-Morales, E., Franciotta, D., Gastaldi, M., Fernandez, O., Urbaneja, P., Garcia-Dominguez, J., Laroni, A., Antonio UCCELLI, Perez-Sempere, A., Saiz, A., Galimberti, D., Scarpini, E., Espejo, C., Montalban, X., Rasche, L., Paul, F., Gonzalez, I., Alvarez, E., Ramo, C., Caminero, A. B., Aladro, Y., Calles, C., Eguia, P., Belenguer-Benavides, A., Ramio, L., Martinez-Rodriguez, J. E., Oterino, A., Lopez Silanes, C., Casanova, L. I., Landete, L., Frederiksen, J., Hernandez, M. A., Prieto, J. M., Perez, D., Otano, M., Padilla, F., Garcia-Merino, A., Navarro, L., Alvarez-Cermeno, J. C., and Villar, L. M.

Published
2017

81. Cerebrospinal fluid kappa and lambda free light chains in oligoclonal band‐negative patients with suspected multiple sclerosis.

Author

Ferraro, D., Trovati, A., Bedin, R., Natali, P., Franciotta, D., Santangelo, M., Camera, V., Vitetta, F., Varani, M., Trenti, T., Gastaldi, M., De Biasi, S., Nasi, M., Pinti, M., Meletti, S., and Sola, P.

Subjects
CEREBROSPINAL fluid, MULTIPLE sclerosis, SERUM albumin, DETECTION limit, BINDING sites
Abstract

Background and purpose: Cerebrospinal fluid (CSF) kappa free light chains (FLCs) may be a more sensitive marker of intrathecal immunoglobulin (Ig)G synthesis compared with oligoclonal bands (OCBs). Our aim was to retrospectively determine the additional value of the kappa and lambda index (CSF FLC/serum FLC)/(CSF albumin/serum albumin) in predicting a multiple sclerosis (MS) diagnosis in a group of OCB‐negative patients with suspected MS. Methods: The CSF and serum kappa and lambda FLCs were tested using the Freelite kit (serum) and Freelite Mx (CSF) assay (The Binding Site Group, Bimingham, UK) in 391 OCB‐negative patients with suspected/possible MS and in 54 OCB‐positive patients with MS. Results: The CSF kappa FLC levels were below the detection limit (0.27 mg/L) in 61% of patients. Using quantitative data, we found the best kappa index cut‐off value for the prediction of MS to be 5.8. A kappa index ≥5.8 was present in 25% of OCB‐negative MS (23/92) and in 98% of OCB‐positive patients with MS. Using a qualitative approach and a kappa index cut‐off of 5.9, based on literature data, we likewise found that 24% of OCB‐negative patients with MS had a kappa index ≥5.9, compared with 5.4% of OCB‐negative patients without MS (P < 0.001). No reliable data could be obtained for the lambda index; lambda FLCs were below the detection limit (0.68 mg/L) in 90% of CSF samples. Conclusions: The kappa index could contribute to the identification of OCB‐negative patients with a high probability of an MS diagnosis. Using more sensitive techniques might even improve the diagnostic performance of the kappa index and better define the role of the lambda index. [ABSTRACT FROM AUTHOR]

Published
2020
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82. P1884Adenosine plasma level in patients with atrial fibrillation and normal heart

Author

Maille, B, primary, Marlingue, M, additional, Mottola, G, additional, Vairo, D, additional, Koutbi, L, additional, Gastaldi, M, additional, Mace, P, additional, Chefrour, M, additional, Michelet, P, additional, Gueant, J L, additional, Boussuges, A, additional, Fenouillet, E, additional, Deharo, J C, additional, Guieu, R, additional, and Franceschi, F, additional

Published
2018
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84. Diagnostics of autoimmune encephalitis associated with antibodies against neuronal surface antigens

Author

Zuliani, L., Zoccarato, M., Gastaldi, M., Iorio, R., Evoli, A., Biagioli, T., Casagrande, S., Bazzigaluppi, E., Fazio, R., Giannotta, C., Nobile-Orazio, E., Andreetta, F., Simoncini, O., Costa, G., Mariotto, S., Ferrari, S., Galloni, E., Marcon, M., Franciotta, D., Giometto, B., Iorio R. (ORCID:0000-0002-6270-0956), Evoli A. (ORCID:0000-0003-0282-8787), Zuliani, L., Zoccarato, M., Gastaldi, M., Iorio, R., Evoli, A., Biagioli, T., Casagrande, S., Bazzigaluppi, E., Fazio, R., Giannotta, C., Nobile-Orazio, E., Andreetta, F., Simoncini, O., Costa, G., Mariotto, S., Ferrari, S., Galloni, E., Marcon, M., Franciotta, D., Giometto, B., Iorio R. (ORCID:0000-0002-6270-0956), and Evoli A. (ORCID:0000-0003-0282-8787)

Abstract

This document presents the guidelines for testing antibodies against neuronal surface antigens that have been developed following a consensus process built on questionnaire-based surveys, internet contacts, and discussions at workshops of the sponsoring Italian Association of Neuroimmunology (AINI) congresses. Essential clinical information on autoimmune encephalitis associated with antibodies against neuronal surface antigens, indications and limits of testing for such antibodies, instructions for result interpretation, and an agreed laboratory protocol (Appendix A) are reported for the communicative community of neurologists and clinical pathologists.

Published
2017

89. A probabilistic approach in estimating optimal evacuation scenarios for seismic emergency management

Author

MARIANO ANGELO ZANINI, Pellegrino, C., Rossi, R., Gastaldi, M., and Modena, C.

Subjects
Statistics and Probability, Civil and Structural Engineering
Abstract

In recent earthquake experiences proper evacuation planning and potential emergency actions to be conducted to help the citizens of the quake municipalities were significant issues. In this work the effects of earthquake scenarios were shown in terms of seismic damages to residential and industrial buildings and also to infrastructural networks through the use of probabilistic approaches. The analyses were conducted on the building and infrastructural assets of the municipality of Conegliano, a town of 40000 inhabitants located in the northern part of the province of Treviso, North-Eastern Italy. A preliminary study on historical seismicity and geological substructures of the surrounding areas was performed, followed by the evaluation of the potential seismic damages to the built heritage. On the basis of these results, the issues of the post-quake accessibility and the management of the inhabitants optimal evacuation using the procedure described in Hadas et al. 2013 were performed. Information about building and infrastructural damages, spatial distribution and capacity of harvesting areas, boundary conditions in terms of predetermined maximum timing for carrying out the evacuation and needed costs for the seismic retrofit of bridges belonging to network links involved in the evacuation were the main input data for the simulations.

Published
2015

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