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52. Analysis of genetic polymorphism of the HLA-B and HLA-DR loci in patients with dermatophytic onychomycosis and in their first-degree relatives.

Author

García-Romero MT, Granados J, Vega-Memije ME, and Arenas R

Subjects
Alleles, Ethnicity genetics, Family Health, Foot Dermatoses epidemiology, Foot Dermatoses ethnology, Gene Frequency, Genetic Predisposition to Disease, HLA-DR Serological Subtypes genetics, Hand Dermatoses epidemiology, Hand Dermatoses ethnology, Haplotypes, Humans, Mexico epidemiology, Onychomycosis epidemiology, Onychomycosis ethnology, Tinea Capitis epidemiology, Foot Dermatoses genetics, Genes, MHC Class I, Genes, MHC Class II, HLA-B Antigens genetics, HLA-DR Antigens genetics, Hand Dermatoses genetics, Onychomycosis genetics, Polymorphism, Genetic, Tinea Capitis genetics
Abstract

Onychomycosis is known to have predisposing factors and a high prevalence within families that cannot be explained by within-family transmission. We determined the frequency of HLA-B and HLA-DR haplotypes in 25 families of Mexican patients with onychomycosis in order to define the role of the class II major histocompatibility complex (MHC) in genetic susceptibility to this infection. Seventy-eight subjects participated in the study, 47 with onychomycosis and 31 healthy individuals. The frequencies of the HLA-B and HLA-DR haplotypes were compared with those found in first-degree relatives without onychomycosis and in a historic control group of healthy individuals. The frequencies in the controls were similar to those of the healthy relatives of the patients. However, on comparison of the patients with historic controls, we detected a higher frequency of the HLA-DR8 haplotype (P=.03; odds ratio, 1.89; 95% confidence interval, 0.98-36). These findings suggest that there are polymorphisms in genes of the MHC that increase susceptibility to onychomycosis, particularly haplotype HLA-DR8., (Copyright © 2010 Elsevier España, S.L. and AEDV. All rights reserved.)

Published
2012
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53. [Analysis of genetic polymorphism of the HLA-B and HLA-DR loci in patients with dermatophytic onychomycosis and in their first-degree relatives].

Author

García-Romero MT, Granados J, Vega-Memije ME, and Arenas R

Subjects
Case-Control Studies, Humans, HLA-B Antigens genetics, HLA-DR Serological Subtypes genetics, Onychomycosis genetics, Polymorphism, Genetic
Abstract

Onychomycosis is known to have predisposing factors and a high prevalence within families that cannot be explained by within-family transmission. We determined the frequency of HLA-B and HLA-DR haplotypes in 25 families of Mexican patients with onychomycosis in order to define the role of the class II major histocompatibility complex (MHC) in genetic susceptibility to this infection. Seventy-eight subjects participated in the study, 47 with onychomycosis and 31 healthy individuals. The frequencies of the HLA-B and HLA-DR haplotypes were compared with those found in first-degree relatives without onychomycosis and in a historic control group of healthy individuals. The frequencies in the controls were similar to those of the healthy relatives of the patients. However, on comparison of the patients with historic controls, we detected a higher frequency of the HLA-DR8 haplotype (P=.03; odds ratio, 1.89; 95% confidence interval, 0.98-36). These findings suggest that there are polymorphisms in genes of the MHC that increase susceptibility to onychomycosis, particularly haplotype HLA-DR8., (Copyright © 2010 Elsevier España, S.L. and AEDV. All rights reserved.)

Published
2012
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54. Zygomycosis in two hematologic cases.

Author

García-Romero MT, García-Méndez J, Arenas R, Ferrari-Carballo T, Chanona-Vilchis J, and Cervera-Ceballos E

Abstract

Zygomycosis are invasive mould infections, rarely diagnosed in hematologic patients. Most of the cases published are in patients with prolonged neutropenia, along with other risk factors such as the use of prior broad-spectrum antibiotics (including new antifungal agents, such as voriconazole), diabetes mellitus (with or without ketoacidosis), malnutrition, iron overload (with or without the use of deferoxamine). These infections have poor prognosis due to the involvement of vital anatomic structures and late diagnosis. Until recent years, the treatment was based on high doses of amphotericin B plus surgical debridement. Here we present two patients with hematologic diseases (one with leukemia, the second with aplastic anemia) with an impaired immune system and the diagnosis of zygomycosis. The survival of one of them was mainly due to early diagnosis and surgical debridement; unfortunately the second was misdiagnosed as an extensive ecchymosis due to thrombocytopenia and died with CNS involvement.

Published
2011
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55. [Past and future of the Revista de Investigación Clínica].

Author

Gamba G, García-Romero MT, and Venado A

Subjects
Authorship, Editorial Policies, Europe, Forecasting, Hospitals statistics & numerical data, Internationality, Internet, Journal Impact Factor, Language, Latin America, Mexico, Publishing standards, Publishing statistics & numerical data, Research Personnel statistics & numerical data, Research Support as Topic, Universities statistics & numerical data, Academies and Institutes statistics & numerical data, Bibliometrics, Biomedical Research statistics & numerical data, Periodicals as Topic statistics & numerical data, Periodicals as Topic trends
Published
2008

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