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1,363 results on '"Gao, Wenyuan"'

54. Grouting Pressure Distribution Model for the Simultaneous Grouting of Shield Tunneling While Considering the Diffusion of Slurry

Author

Zhou, Zhong, Liu, Zhuangzhuang, Zhang, Binran, Gao, Wenyuan, Zhang, Chengcheng, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Tutumluer, Erol, editor, Chen, Xiaobin, editor, and Xiao, Yuanjie, editor

Published
2020
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94. Exploring Spatiotemporal Characteristics and Driving Forces of Straw Burning in Hunan Province, China, from 2010 to 2020.

Author

Zeng, Yu, Liu, Shuguang, Huang, Sheng, Patil, Sopan D., Gao, Wenyuan, and Li, Hao

Subjects
MODIS (Spectroradiometer), STRAW, TRACE gases, BORDERLANDS, PARTICULATE matter, WHEAT straw
Abstract

Straw burning is a significant source of atmospheric pollutants, releasing particulate matter and trace gases. Capturing the characteristics of straw burning and understanding its influencing factors are important prerequisites for regulating straw burning. Based on the fire points detected by the Moderate-resolution Imaging Spectroradiometer (MODIS) in Hunan province, China, from 2010 to 2020, this study analyzed the spatiotemporal variations of straw burning and employed Geographically Weighted Regression (GWR) models to investigate the underlying forces driving straw burning. The results show that the spatiotemporal characteristics of straw burning in Hunan Province can be categorized into two distinct periods: 2010 to 2014 and 2015 to 2020. The period from 2010 to 2014 witnessed a rapid increase, while the period from 2015 to 2020 experienced fluctuating decreases. The shift is closely linked to the implementation of the straw burning ban policy in 2015. Spatially, the areas with a high number of fire points are primarily located in the southern regions, especially in the border regions between Chenzhou, Yongzhou, Hengyang, and Shaoyang cities. A significant change was found in the impact of economic development and human activity factors on straw burning before and after 2015. These factors include crop yield, Gross Domestic Product (GDP), and road network development. From the implementation of the straw burning ban policy, increases in GDP and settlement density will have a dampening effect on straw burning in a region. Straw burning locations may shift towards regions with relatively slow economic development. The results could serve as a foundation for decision-making to address the issue of straw burning. [ABSTRACT FROM AUTHOR]

Published
2024
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95. The lipid droplet in cancer: From being a tumor‐supporting hallmark to clinical therapy.

Author

Cui, Yingfang, Man, Shuli, Tao, Jiejing, Liu, Yu, Ma, Long, Guo, Lanping, Huang, Luqi, Liu, Changxiao, and Gao, Wenyuan

Subjects
CLINICAL drug trials, FREE fatty acids, LIPID metabolism, LIFE cycles (Biology), LIPIDS
Abstract

Introduction: Abnormal lipid metabolism, one of the hallmarks in cancer, has gradually emerged as a novel target for cancer treatment. As organelles that store and release excess lipids, lipid droplets (LDs) resemble "gears" and facilitate cancer development in the body. Aim: This review discusses the life cycle of LDs, the relationship between abnormal LDs and cancer hallmarks, and the application of LDs in theragnostic and clinical contexts to provide a contemporary understanding of the role of LDs in cancer. Methods: A systematic literature search was conducted in PubMed and SPORTDiscus. Retrieve and summarize clinical trials of drugs that target proteins associated with LD formation using the Clinical Trials website. Create a schematic diagram of lipid droplets in the tumor microenvironment using Adobe Illustrator. Conclusion: As one of the top ten hallmarks of cancer, abnormal lipid metabolism caused by excessive generation of LDs interrelates with other hallmarks. The crosstalk between excessive LDs and intracellular free fatty acids (FFAs) promotes an inflammatory environment that supports tumor growth. Moreover, LDs contribute to cancer metastasis and cell death resistance in vivo. Statins, as HMGCR inhibitors, are promising to be the pioneering commercially available anti‐cancer drugs that target LD formation. [ABSTRACT FROM AUTHOR]

Published
2024
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