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52. Immunological configuration of ovarian carcinoma: features and impact on disease outcome

Author

Fucikova, Jitka, Coosemans, An, Orsulic, Sandra, Cibula, David, Vergote, Ignace, Galluzzi, Lorenzo, and Spisek, Radek

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Rare Diseases, Cancer, Orphan Drug, Ovarian Cancer, Clinical Trials and Supportive Activities, Carcinoma, Ovarian Epithelial, Female, Humans, Immunosuppression Therapy, Immunotherapy, Treatment Outcome, Tumor Microenvironment, immunologic surveillance, immunotherapy, tumor biomarkers, tumor microenvironment, genital neoplasms, female, Oncology and carcinogenesis
Abstract

Epithelial ovarian carcinoma (EOC) is a relatively rare malignancy but is the fifth-leading cause of cancer-related death in women, largely reflecting early, prediagnosis dissemination of malignant disease to the peritoneum. At odds with other neoplasms, EOC is virtually insensitive to immune checkpoint inhibitors, correlating with a tumor microenvironment that exhibits poor infiltration by immune cells and active immunosuppression. Here, we comparatively summarize the humoral and cellular features of primary and metastatic EOC, comparatively analyze their impact on disease outcome, and propose measures to alter them in support of treatment sensitivity and superior patient survival.

Published
2021

53. Computer extracted gland features from H&E predicts prostate cancer recurrence comparably to a genomic companion diagnostic test: a large multi-site study.

Author

Leo, Patrick, Janowczyk, Andrew, Elliott, Robin, Janaki, Nafiseh, Bera, Kaustav, Shiradkar, Rakesh, Farré, Xavier, Fu, Pingfu, El-Fahmawi, Ayah, Shahait, Mohammed, Kim, Jessica, Lee, David, Yamoah, Kosj, Rebbeck, Timothy R, Khani, Francesca, Robinson, Brian D, Eklund, Lauri, Jambor, Ivan, Merisaari, Harri, Ettala, Otto, Taimen, Pekka, Aronen, Hannu J, Boström, Peter J, Tewari, Ashutosh, Magi-Galluzzi, Cristina, Klein, Eric, Purysko, Andrei, Nc Shih, Natalie, Feldman, Michael, Gupta, Sanjay, Lal, Priti, and Madabhushi, Anant

Abstract

Existing tools for post-radical prostatectomy (RP) prostate cancer biochemical recurrence (BCR) prognosis rely on human pathologist-derived parameters such as tumor grade, with the resulting inter-reviewer variability. Genomic companion diagnostic tests such as Decipher tend to be tissue destructive, expensive, and not routinely available in most centers. We present a tissue non-destructive method for automated BCR prognosis, termed "Histotyping", that employs computational image analysis of morphologic patterns of prostate tissue from a single, routinely acquired hematoxylin and eosin slide. Patients from two institutions (n = 214) were used to train Histotyping for identifying high-risk patients based on six features of glandular morphology extracted from RP specimens. Histotyping was validated for post-RP BCR prognosis on a separate set of n = 675 patients from five institutions and compared against Decipher on n = 167 patients. Histotyping was prognostic of BCR in the validation set (p

Published
2021

54. Immune checkpoint inhibitor-associated myocarditis: manifestations and mechanisms.

Author

Moslehi, Javid, Lichtman, Andrew, Sharpe, Arlene, Galluzzi, Lorenzo, and Kitsis, Richard

Subjects
Biomarkers, Humans, Immune Checkpoint Inhibitors, Myocarditis
Abstract

Immune checkpoint inhibitors (ICIs) have transformed the treatment of various cancers, including malignancies once considered untreatable. These agents, however, are associated with inflammation and tissue damage in multiple organs. Myocarditis has emerged as a serious ICI-associated toxicity, because, while seemingly infrequent, it is often fulminant and lethal. The underlying basis of ICI-associated myocarditis is not completely understood. While the importance of T cells is clear, the inciting antigens, why they are recognized, and the mechanisms leading to cardiac cell injury remain poorly characterized. These issues underscore the need for basic and clinical studies to define pathogenesis, identify predictive biomarkers, improve diagnostic strategies, and develop effective treatments. An improved understanding of ICI-associated myocarditis will provide insights into the equilibrium between the immune and cardiovascular systems.

Published
2021

56. Apoptotic cell death in disease—Current understanding of the NCCD 2023

Author

Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A., Abrams, John M., Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S., Altucci, Lucia, Amelio, Ivano, Andrews, David W., Aqeilan, Rami I., Arama, Eli, Baehrecke, Eric H., Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A., Bartek, Jiri, Bazan, Nicolas G., Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J. M., Bianchi, Marco E., Blagosklonny, Mikhail V., Blander, J. Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D., Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A., Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K. -M., Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H., Cheng, Emily H., Chipuk, Jerry E., Cidlowski, John A., Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R., Czabotar, Peter E., D’Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M., Dawson, Valina L., De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J., Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J., Dynlacht, Brian D., El-Deiry, Wafik S., Elrod, John W., Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J., Garg, Abhishek D., Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R., Greene, Lloyd A., Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J. Marie, Haupt, Ygal, He, Sudan, Heery, David M., Hengartner, Michael O., Hetz, Claudio, Hildeman, David A., Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J., Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L., Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N., Klionsky, Daniel J., Kluck, Ruth, Krysko, Dmitri V., Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N., Lemasters, John J., Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A., Lockshin, Richard A., López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J., Martinou, Jean-Claude, Mastroberardino, Pier G., Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A., Moll, Ute M., Muñoz-Pinedo, Cristina, Murphy, Daniel J., Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T., Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M., Pentimalli, Francesca, Pereira, David M., Pervaiz, Shazib, Peter, Marcus E., Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H. M., Puthalakath, Hamsa, Rabinovich, Gabriel A., Rajalingam, Krishnaraj, Ravichandran, Kodi S., Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M. P., Rotblat, Barak, Rothlin, Carla V., Rubinsztein, David C., Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M., Sarosiek, Kristopher A., Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S., Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R., Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W. G., Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M., Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G., Vanderluit, Jacqueline L., Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K., Vousden, Karen H., Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F., Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E., Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, and Galluzzi, Lorenzo

Published
2023
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60. Intrinsic Anisotropy and Pinning Anisotropy in Nanostructured YBa$_2$Cu$_3$O$_{7-\delta}$ from Microwave Measurements

Author

Pompeo, N., Alimenti, A, Torokhtii, K, Bartolomé, E, Palau, A, Puig, T, Augieri, A, Galluzzi, V, Mancini, A, Celentano, G, Obradors, X, and Silva, E

Subjects
Condensed Matter - Superconductivity
Abstract

Anisotropy is an intrinsic factor that dictates the magnetic properties of YBCO, thus with great impact for many applications. Artificial pinning centres are often introduced in an attempt to mitigate its effect, resulting in less anisotropic electrical and magnetic properties. However, the nanoengineering of the superconductor makes the quantification of the anisotropy itself uncertain: the intrinsic anisotropy due to the layered structure, quantified by the anisotropy factor $\gamma$, mixes up with the additional anisotropy due to pinning. As a consequence, there is no consensus on the experimental anisotropy factor $\gamma$ that can result in YBCO when directional (twin planes, nanorods) or isotropic defects are present. We present here measurements of the magnetic field and angular dependent surface impedance in very different nanostructured YBCO films, grown by chemical route and by pulsed laser deposition, with different kind of defects (nanorods, twin planes, nanoparticles). We show that the surface impedance measurements are able to disentangle the intrinsic anisotropy from the directional pinning anisotropy, thanks to the possibility to extract the true anisotropic flux--flow resistivity and by correctly exploiting the angular scaling. We find in all films that the intrinsic anisotropy $\gamma = 5.3\pm0.7$. By contrast, the pinning anisotropy determines a much complex, feature--rich and nonuniversal, sample--dependent angular landscape., Comment: 24 pages, 11 figures, submitted to IOP

Published
2020
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61. A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI

Author

Li, Lin, Shiradkar, Rakesh, Leo, Patrick, Algohary, Ahmad, Fu, Pingfu, Tirumani, Sree Harsha, Mahran, Amr, Buzzy, Christina, Obmann, Verena C, Mansoori, Bahar, El-Fahmawi, Ayah, Shahait, Mohammed, Tewari, Ashutosh, Magi-Galluzzi, Cristina, Lee, David, Lal, Priti, Ponsky, Lee, Klein, Eric, Purysko, Andrei S, and Madabhushi, Anant

Subjects
Aging, Prostate Cancer, Cancer, Biomedical Imaging, Patient Safety, Urologic Diseases, Good Health and Well Being, Aged, Aged, 80 and over, Biomarkers, Tumor, Clinical Decision-Making, Diagnostic Imaging, Disease Management, Humans, Kaplan-Meier Estimate, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Nomograms, Patient Selection, Perioperative Care, Prognosis, Prostatectomy, Prostatic Neoplasms, Retrospective Studies, Workflow, Prostate cancer, Biochemical recurrence, Adverse pathology, Radiomic, MRI, Clinical Sciences, Public Health and Health Services
Abstract

BackgroundWe developed and validated an integrated radiomic-clinicopathologic nomogram (RadClip) for post-surgical biochemical recurrence free survival (bRFS) and adverse pathology (AP) prediction in men with prostate cancer (PCa). RadClip was further compared against extant prognostics tools like CAPRA and Decipher.MethodsA retrospective study of 198 patients with PCa from four institutions who underwent pre-operative 3 Tesla MRI followed by radical prostatectomy, between 2009 and 2017 with a median 35-month follow-up was performed. Radiomic features were extracted from prostate cancer regions on bi-parametric magnetic resonance imaging (bpMRI). Cox Proportional-Hazards (CPH) model warped with minimum redundancy maximum relevance (MRMR) feature selection was employed to select bpMRI radiomic features for bRFS prediction in the training set (D1, N = 71). In addition, a bpMRI radiomic risk score (RadS) and associated nomogram, RadClip, were constructed in D1 and then compared against the Decipher, pre-operative (CAPRA), and post-operative (CAPRA-S) nomograms for bRFS and AP prediction in the testing set (D2, N = 127).Findings"RadClip yielded a higher C-index (0.77, 95% CI 0.65-0.88) compared to CAPRA (0.68, 95% CI 0.57-0.8) and Decipher (0.51, 95% CI 0.33-0.69) and was found to be comparable to CAPRA-S (0.75, 95% CI 0.65-0.85). RadClip resulted in a higher AUC (0.71, 95% CI 0.62-0.81) for predicting AP compared to Decipher (0.66, 95% CI 0.56-0.77) and CAPRA (0.69, 95% CI 0.59-0.79)."InterpretationRadClip was more prognostic of bRFS and AP compared to Decipher and CAPRA. It could help pre-operatively identify PCa patients at low risk of biochemical recurrence and AP and who therefore might defer additional therapy.FundingThe National Institutes of Health, the U.S. Department of Veterans Affairs, and the Department of Defense.

Published
2021

62. ALMA Band 3 polarimetric follow-up of a complete sample of faint PACO sources

Author

Galluzzi, Vincenzo, Puglisi, Giuseppe, Burkutean, Sandra, Liuzzo, Elisabetta, Bonato, Matteo, Massardi, Marcella, Paladino, Rosita, Gregorini, Loretta, Ricci, Roberto, Trombetti, Tiziana, Toffolatti, Luigi, Burigana, Carlo, Bonaldi, Anna, Bonavera, Laura, Casasola, Viviana, De Zotti, Gianfranco, Ekers, Ronald David, Alighieri, Sperello di Serego, López-Caniego, Marcos, and Tucci, Marco

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present Atacama Large Millimeter/submillimiter Array (ALMA) high sensitivity ($\sigma_P \simeq 0.4\,$mJy) polarimetric observations at $97.5\,$GHz (Band 3) of a complete sample of $32$ extragalactic radio sources drawn from the faint Planck-ATCA Co-eval Observations (PACO) sample ($b<-75^\circ$, compact sources brighter than $200\,$mJy at $20\,$GHz). We achieved a detection rate of $~97\%$ at $3\,\sigma$ (only $1$ non-detection). We complement these observations with new Australia Telescope Compact Array (ATCA) data between $2.1$ and $35\,$GHz obtained within a few months and with data published in earlier papers from our collaboration. Adding the co-eval GaLactic and Extragalactic All-sky Murchison widefield array (GLEAM) survey detections between $70\,$ and $230\,$MHz for our sources, we present spectra over more than $3$ decades in frequency in total intensity and over about $1.7$ decades in polarization. The spectra of our sources are smooth over the whole frequency range, with no sign of dust emission from the host galaxy at mm wavelengths nor of a sharp high frequency decline due, for example, to electron ageing. We do however find indications of multiple emitting components and present a classification based on the number of detected components. We analyze the polarization fraction behaviour and distributions up to $97\,$GHz for different source classes. Source counts in polarization are presented at $95\,$GHz., Comment: 18 pages, 11 figures, accepted for publication in MNRAS

Published
2019
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63. Occupancy Estimation Using Low-Cost Wi-Fi Sniffers

Author

Galluzzi, Paolo, Longo, Edoardo, Redondi, Alessandro E. C., and Cesana, Matteo

Subjects
Computer Science - Networking and Internet Architecture, Electrical Engineering and Systems Science - Signal Processing
Abstract

Real-time measurements on the occupancy status of indoor and outdoor spaces can be exploited in many scenarios (HVAC and lighting system control, building energy optimization, allocation and reservation of spaces, etc.). Traditional systems for occupancy estimation rely on environmental sensors (CO2, temperature, humidity) or video cameras. In this paper, we depart from such traditional approaches and propose a novel occupancy estimation system which is based on the capture of Wi-Fi management packets from users' devices. The system, implemented on a low-cost ESP8266 microcontroller, leverages a supervised learning model to adapt to different spaces and transmits occupancy information through the MQTT protocol to a web-based dashboard. Experimental results demonstrate the validity of the proposed solution in four different indoor university spaces., Comment: Submitted to Balkancom 2018

Published
2019

64. Radio sources in next-generation CMB surveys

Author

De Zotti, Gianfranco, Bonato, Matteo, Negrello, Mattia, Herranz, Diego, Lopez-Caniego, Marcos, Trombetti, Tiziana, Burigana, Carlo, Massardi, Marcella, Bonavera, Laura, Gonzalez-Nuevo, Joaquin, Galluzzi, Vincenzo, and Hanany, Shaul

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

CMB surveys provide, for free, blindly selected samples of extragalactic radio sources at much higher frequencies than traditional radio surveys. Next-generation, ground-based CMB experiments with arcmin resolution at mm wavelengths will provide samples of thousands radio sources allowing the investigation of the evolutionary properties of blazar populations, the study of the earliest and latest stages of radio activity, the discovery of rare phenomena and of new transient sources and events. Space-borne experiments will extend to sub-mm wavelengths the determinations of the SEDs of many hundreds of blazars, in temperature and in polarization, allowing us to investigate the flow and the structure of relativistic jets close to their base, and the electron acceleration mechanisms. A real breakthrough will be achieved in the caracterization of the polarization properties. The first direct counts in polarization will be obtained, enabling a solid assessment of the extra-galactic source contamination of CMB maps and allowing us to understand structure and intensity of magnetic fields, particle densities and structures of emitting regions close to the base of the jet., Comment: Science white paper submitted to the Astro2020 US Decadal Survey

Published
2019

65. Beth Levine in memoriam

Author

An, Zhenyi, Ballabio, Andrea, Bennett, Lynda, Boya, Patricia, Cecconi, Francesco, Chiang, Wei-Chung, Codogno, Patrice, Colombo, Maria Isabel, Cuervo, Ana Maria, Debnath, Jayanta, Deretic, Vojo, Dikic, Ivan, Dionne, Keith, Dong, Xiaonan, Elazar, Zvulun, Galluzzi, Lorenzo, Gentile, Frank, Griffin, Diane E, Hansen, Malene, Hardwick, J Marie, He, Congcong, Huang, Shu-Yi, Hurley, James, Jackson, William T, Jozefiak, Cindy, Kitsis, Richard N, Klionsky, Daniel J, Kroemer, Guido, Meijer, Alfred J, Melendez, Alicia, Melino, Gerry, Mizushima, Noboru, Murphy, Leon O, Nixon, Ralph, Orvedahl, Anthony, Pattingre, Sophie, Piacentini, Mauro, Reggiori, Fulvio, Ross, Theodora, Rubinsztein, David C, Ryan, Kevin, Sadoshima, Junichi, Schreiber, Stuart L, Scott, Frederick, Sebti, Salwa, Shiloh, Michael, Shoji, Sanae, Simonsen, Anne, Smith, Haley, Sumpter, Kathryn M, Thompson, Craig B, Thorburn, Andrew, Thumm, Michael, Tooze, Sharon, Vaccaro, Maria I, Virgin, Herbert W, Wang, Fei, White, Eileen, Xavier, Ramnik J, Yoshimori, Tamotsu, Yuan, Junying, Yue, Zhenyu, and Zhong, Qing

Subjects
Biochemistry and Cell Biology, Biological Sciences, Biochemistry & Molecular Biology, Biochemistry and cell biology
Published
2020

66. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Author

Galluzzi, Lorenzo, Vitale, Ilio, Warren, Sarah, Adjemian, Sandy, Agostinis, Patrizia, Martinez, Aitziber Buqué, Chan, Timothy A, Coukos, George, Demaria, Sandra, Deutsch, Eric, Draganov, Dobrin, Edelson, Richard L, Formenti, Silvia C, Fucikova, Jitka, Gabriele, Lucia, Gaipl, Udo S, Gameiro, Sofia R, Garg, Abhishek D, Golden, Encouse, Han, Jian, Harrington, Kevin J, Hemminki, Akseli, Hodge, James W, Hossain, Dewan Md Sakib, Illidge, Tim, Karin, Michael, Kaufman, Howard L, Kepp, Oliver, Kroemer, Guido, Lasarte, Juan Jose, Loi, Sherene, Lotze, Michael T, Manic, Gwenola, Merghoub, Taha, Melcher, Alan A, Mossman, Karen L, Prosper, Felipe, Rekdal, Øystein, Rescigno, Maria, Riganti, Chiara, Sistigu, Antonella, Smyth, Mark J, Spisek, Radek, Stagg, John, Strauss, Bryan E, Tang, Daolin, Tatsuno, Kazuki, van Gool, Stefaan W, Vandenabeele, Peter, Yamazaki, Takahiro, Zamarin, Dmitriy, Zitvogel, Laurence, Cesano, Alessandra, and Marincola, Francesco M

Subjects
Inflammatory and immune system, Consensus, Guidelines as Topic, Humans, Immunogenic Cell Death, Molecular Biology, oncology, immunology, molecular biology
Abstract

Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

Published
2020

67. Clinicopathologic and molecular spectrum of testicular sex cord-stromal tumors not amenable to specific histopathologic subclassification

Author

Siegmund, Stephanie E., Sholl, Lynette M., Tsai, Harrison K., Yang, Yiying, Vasudevaraja, Varshini, Tran, Ivy, Snuderl, Matija, Fletcher, Christopher D. M., Cornejo, Kristine M., Idrees, Muhammad T., Al-Obaidy, Khaleel I., Collins, Katrina, Gordetsky, Jennifer B., Wobker, Sara E., Hirsch, Michelle S., Trpkov, Kiril, Yilmaz, Asli, Anderson, William J., Quiroga-Garza, Gabriela, Magi-Galluzzi, Cristina, Canete-Portillo, Sofia, and Acosta, Andres M.

Published
2022
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69. A note on divisorial correspondences of extensions of abelian schemes by tori

Author

Bertolin, Cristiana and Galluzzi, Federica

Subjects
Mathematics - Algebraic Geometry, Mathematics - Number Theory
Abstract

Let S be a locally noetherian scheme and consider two extensions G_1 and G_2 of abelian S-schemes by S-tori. In this note we prove that the fppf-sheaf Corr _S(G_1,G_2) of divisorial correspondences between G_1 and G_2 is representable. Moreover, using divisorial correspondences, we show that line bundles on an extension G of an abelian scheme by a torus define group homomorphisms between G and Pic_{ G/S}., Comment: new version

Published
2019

71. Abundance and size-frequency distributions of boulders in Linne crater's ejecta (Moon)

Author

Pajola, Maurizio, Pozzobon, Riccardo, Lucchetti, Alice, Rossato, Sandro, Baratti, Emanuele, Galluzzi, Valentina, and Cremonese, Gabriele

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

This paper presents the abundances and the size-frequency distributions (SFD) of the ejected boulders surrounding the Linne crater, located on the Moon's Mare Serenitatis basin. By means of Lunar Reconnaissance Orbiter Camera high-resolution images we prepare a context geological map of the Linne crater as well as we identify 12000 boulders > 4.4 m, with a maximum measured size of 30.8 m. The cumulative number of boulders per km2 is fitted with a power-law curve with index -4.03 +0.09/-0.10. By studying the radial ejecta abundances, we find that the largest ones are located within the first 2 km from the crater's centre, while few tens of boulders with sizes < 8 m are detectable above 5 km from the crater's rim. We find that the Linne proximal ejecta blanket is slightly asymmetrical, as indicated in the geological map too, showing a density increase in the NE-SW direction. This may be the result of an oblique impact emplacement of the original impactor, or it may be explained with a perpendicular impact in the Mare Serenitatis location, but on a surface with lunar basalts with different local mechanical properties. By exploiting our boulders size density as a function of the distance from the crater's centre, we derive a possible regolith thickness at the Linne impact of 4.75 m, supporting similar values based on Earth-based radar and optical data in the Mare Serenitatis basin., Comment: Paper accepted by Planetary and Space Science Journal on 27 Nov 2018

Published
2018

72. The Tiered Radio Extragalactic Continuum Simulation (T-RECS)

Author

Bonaldi, Anna, Bonato, Matteo, Galluzzi, Vincenzo, Harrison, Ian, Massardi, Marcella, Kay, Scott, De Zotti, Gianfranco, and Brown, Michael L.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present the Tiered Radio Extragalactic Continuum Simulation (T-RECS): a new simulation of the radio sky in continuum, over the 150 MHz-20 GHz range. T-RECS models two main populations of radio galaxies: Active Galactic Nuclei (AGNs) and Star-Forming Galaxies (SFGs), and corresponding sub-populations. Our model also includes polarized emission over the full frequency range, which has been characterised statistically for each population using the available information. We model the clustering properties in terms of probability distributions of hosting halo masses, and use lightcones extracted from a high-resolution cosmological simulation to determine the positions of haloes. This limits the sky area for the simulations including clustering to a 25deg2 field of view. We compare luminosity functions, number counts in total intensity and polarization, and clustering properties of our outputs to up-to-date compilations of data and find a very good agreement. We deliver a set of simulated catalogues, as well as the code to produce them, which can be used for simulating observations and predicting results from deep radio surveys with existing and forthcoming radio facilities, such as the Square Kilometre Array (SKA)., Comment: 20 pages, 11 figures, accepted by MNRAS

Published
2018
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73. ALMACAL IV: A catalogue of ALMA calibrator continuum observations

Author

Bonato, M., Liuzzo, E., Giannetti, A., Massardi, M., De Zotti, G., Burkutean, S., Galluzzi, V., Negrello, M., Baronchelli, I., Brand, J., Zwaan, M. A., Rygl, K. L. J., Marchili, N., Klitsch, A., and Oteo, I.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present a catalogue of ALMA flux density measurements of 754 calibrators observed between August 2012 and September 2017, for a total of 16,263 observations in different bands and epochs. The flux densities were measured reprocessing the ALMA images generated in the framework of the ALMACAL project, with a new code developed by the Italian node of the European ALMA Regional Centre. A search in the online databases yielded redshift measurements for 589 sources ($\sim$78 per cent of the total). Almost all sources are flat-spectrum, based on their low-frequency spectral index, and have properties consistent with being blazars of different types. To illustrate the properties of the sample we show the redshift and flux density distributions as well as the distributions of the number of observations of individual sources and of time spans in the source frame for sources observed in bands 3 (84$-$116 GHz) and 6 (211$-$275 GHz). As examples of the scientific investigations allowed by the catalogue we briefly discuss the variability properties of our sources in ALMA bands 3 and 6 and the frequency spectra between the effective frequencies of these bands. We find that the median variability index steadily increases with the source-frame time lag increasing from 100 to 800 days, and that the frequency spectra of BL Lacs are significantly flatter than those of flat-spectrum radio quasars. We also show the global spectral energy distributions of our sources over 17 orders of magnitude in frequency., Comment: 8 pages, 9 figures, 2 tables, MNRAS accepted

Published
2018
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74. Proliferative potential and resistance to immune checkpoint blockade in lung cancer patients

Author

Pabla, Sarabjot, Conroy, Jeffrey M, Nesline, Mary K, Glenn, Sean T, Papanicolau-Sengos, Antonios, Burgher, Blake, Hagen, Jacob, Giamo, Vincent, Andreas, Jonathan, Lenzo, Felicia L, Yirong, Wang, Dy, Grace K, Yau, Edwin, Early, Amy, Chen, Hongbin, Bshara, Wiam, Madden, Katherine G, Shirai, Keisuke, Dragnev, Konstantin, Tafe, Laura J, Marin, Daniele, Zhu, Jason, Clarke, Jeff, Labriola, Matthew, McCall, Shannon, Zhang, Tian, Zibelman, Matthew, Ghatalia, Pooja, Araujo-Fernandez, Isabel, Singavi, Arun, George, Ben, MacKinnon, Andrew Craig, Thompson, Jonathan, Singh, Rajbir, Jacob, Robin, Dressler, Lynn, Steciuk, Mark, Binns, Oliver, Kasuganti, Deepa, Shah, Neel, Ernstoff, Marc, Odunsi, Kunle, Kurzrock, Razelle, Gardner, Mark, Galluzzi, Lorenzo, and Morrison, Carl

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Lung, Genetics, Cancer, Lung Cancer, Clinical Research, Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Immunological, B7-H1 Antigen, Base Sequence, Biomarkers, Carcinoma, Non-Small-Cell Lung, Cell Proliferation, Drug Resistance, Neoplasm, Female, Humans, Lung Neoplasms, Male, Middle Aged, Survival Analysis, Atezolizumab, Nivolumab, Pembrolizumab, Ipilimumab, PD-1, Oncology and carcinogenesis
Abstract

BackgroundResistance to immune checkpoint inhibitors (ICIs) has been linked to local immunosuppression independent of major ICI targets (e.g., PD-1). Clinical experience with response prediction based on PD-L1 expression suggests that other factors influence sensitivity to ICIs in non-small cell lung cancer (NSCLC) patients.MethodsTumor specimens from 120 NSCLC patients from 10 institutions were evaluated for PD-L1 expression by immunohistochemistry, and global proliferative profile by targeted RNA-seq.ResultsCell proliferation, derived from the mean expression of 10 proliferation-associated genes (namely BUB1, CCNB2, CDK1, CDKN3, FOXM1, KIAA0101, MAD2L1, MELK, MKI67, and TOP2A), was identified as a marker of response to ICIs in NSCLC. Poorly, moderately, and highly proliferative tumors were somewhat equally represented in NSCLC, with tumors with the highest PD-L1 expression being more frequently moderately proliferative as compared to lesser levels of PD-L1 expression. Proliferation status had an impact on survival in patients with both PD-L1 positive and negative tumors. There was a significant survival advantage for moderately proliferative tumors compared to their combined highly/poorly counterparts (p = 0.021). Moderately proliferative PD-L1 positive tumors had a median survival of 14.6 months that was almost twice that of PD-L1 negative highly/poorly proliferative at 7.6 months (p = 0.028). Median survival in moderately proliferative PD-L1 negative tumors at 12.6 months was comparable to that of highly/poorly proliferative PD-L1 positive tumors at 11.5 months, but in both instances less than that of moderately proliferative PD-L1 positive tumors. Similar to survival, proliferation status has impact on disease control (DC) in patients with both PD-L1 positive and negative tumors. Patients with moderately versus those with poorly or highly proliferative tumors have a superior DC rate when combined with any classification schema used to score PD-L1 as a positive result (i.e., TPS ≥ 50% or ≥ 1%), and best displayed by a DC rate for moderately proliferative tumors of no less than 40% for any classification of PD-L1 as a negative result. While there is an over representation of moderately proliferative tumors as PD-L1 expression increases this does not account for the improved survival or higher disease control rates seen in PD-L1 negative tumors.ConclusionsCell proliferation is potentially a new biomarker of response to ICIs in NSCLC and is applicable to PD-L1 negative tumors.

Published
2019

75. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

Author

Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M, De Carvalho, Daniel D, DeNardo, David G, Galon, Jérôme, Kaufman, Howard L, Kirchhoff, Tomas, Lotze, Michael T, Luke, Jason J, Minn, Andy J, Politi, Katerina, Shultz, Leonard D, Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B, Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M, Barsan, Valentin, Bommareddy, Praveen K, Bot, Adrian, Church, Sarah E, Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S, McGee, Heather M, Monette, Anne, Murphy, Joseph F, Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F, Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H, Disis, Mary L, Fox, Bernard A, Cesano, Alessandra, and Marincola, Francesco M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Cancer, Women's Health, Human Genome, Genetics, 2.1 Biological and endogenous factors, 1.1 Normal biological development and functioning, Generic health relevance, Good Health and Well Being, Advisory Committees, Animals, Biomarkers, Tumor, Congresses as Topic, Disease Models, Animal, Humans, Immunotherapy, Medical Oncology, Neoplasms, Societies, Medical, Treatment Outcome, Tumor Microenvironment, Cancer immune responsiveness, Immune checkpoint inhibitor, Immune oncology, Tumor microenvironment, Tumor mutational burden, Immunogenic cell death, Biomarker, Germline molecular alterations, Somatic molecular alterations, Cancer immune phenotype, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups, Oncology and carcinogenesis
Abstract

Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes arising within a cell biologic process, whose deviations from normality determine the rules of engagement with the host's response, the Society for Immunotherapy of Cancer (SITC) convened a task force of experts from various disciplines including, immunology, oncology, biophysics, structural biology, molecular and cellular biology, genetics, and bioinformatics to address the complexity of CIR from a holistic view. The task force was launched by a workshop held in San Francisco on May 14-15, 2018 aimed at two preeminent goals: 1) to identify the fundamental questions related to CIR and 2) to create an interactive community of experts that could guide scientific and research priorities by forming a logical progression supported by multiple perspectives to uncover mechanisms of CIR. This workshop was a first step toward a second meeting where the focus would be to address the actionability of some of the questions identified by working groups. In this event, five working groups aimed at defining a path to test hypotheses according to their relevance to human cancer and identifying experimental models closest to human biology, which include: 1) Germline-Genetic, 2) Somatic-Genetic and 3) Genomic-Transcriptional contributions to CIR, 4) Determinant(s) of Immunogenic Cell Death that modulate CIR, and 5) Experimental Models that best represent CIR and its conversion to an immune responsive state. This manuscript summarizes the contributions from each group and should be considered as a first milestone in the path toward a more contemporary understanding of CIR. We appreciate that this effort is far from comprehensive and that other relevant aspects related to CIR such as the microbiome, the individual's recombined T cell and B cell receptors, and the metabolic status of cancer and immune cells were not fully included. These and other important factors will be included in future activities of the taskforce. The taskforce will focus on prioritization and specific actionable approach to answer the identified questions and implementing the collaborations in the follow-up workshop, which will be held in Houston on September 4-5, 2019.

Published
2019

76. Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

Author

Bedognetti, Davide, Ceccarelli, Michele, Galluzzi, Lorenzo, Lu, Rongze, Palucka, Karolina, Samayoa, Josue, Spranger, Stefani, Warren, Sarah, Wong, Kwok-Kin, Ziv, Elad, Chowell, Diego, Coussens, Lisa M, De Carvalho, Daniel D, DeNardo, David G, Galon, Jérôme, Kaufman, Howard L, Kirchhoff, Tomas, Lotze, Michael T, Luke, Jason J, Minn, Andy J, Politi, Katerina, Shultz, Leonard D, Simon, Richard, Thórsson, Vésteinn, Weidhaas, Joanne B, Ascierto, Maria Libera, Ascierto, Paolo Antonio, Barnes, James M, Barsan, Valentin, Bommareddy, Praveen K, Bot, Adrian, Church, Sarah E, Ciliberto, Gennaro, De Maria, Andrea, Draganov, Dobrin, Ho, Winson S, McGee, Heather M, Monette, Anne, Murphy, Joseph F, Nisticò, Paola, Park, Wungki, Patel, Maulik, Quigley, Michael, Radvanyi, Laszlo, Raftopoulos, Harry, Rudqvist, Nils-Petter, Snyder, Alexandra, Sweis, Randy F, Valpione, Sara, Zappasodi, Roberta, Butterfield, Lisa H, Disis, Mary L, Fox, Bernard A, Cesano, Alessandra, and Marincola, Francesco M

Subjects
Biomedical and Clinical Sciences, Immunology, Cancer, Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups, Oncology and carcinogenesis
Abstract

Following publication of the original article [1], the author reported that an author name, Roberta Zappasodi, was missed in the authorship list.

Published
2019

77. Ensuring remote diagnostics for pathologists: an open letter to the US Congress

Author

Lennerz, Jochen K., Pantanowitz, Liron, Amin, Mitual B., Eltoum, Isam-Eldin, Hameed, Meera R., Kalof, Alexana N., Khanafshar, Elham, Kunju, Lakshmi P., Lazenby, Audrey J., Montone, Kathleen T., Otis, Christopher N., Reid, Michelle D., Staats, Paul N., Whitney-Miller, Christa L., Abendroth, Catherine S., Aron, Manju, Birdsong, George G., Bleiweiss, Ira J., Bronner, Mary P., Chapman, Jennifer, Cipriani, Nicole A., de la Roza, Gustavo, Esposito, Michael J., Fadare, Oluwole, Ferrer, Karen, Fletcher, Christopher D., Frishberg, David P., Garcia, Fernando U., Geldenhuys, Laurette, Gill, Ryan M., Gui, Dorina, Halat, Shams, Hameed, Omar, Hornick, Jason L., Huber, Aaron R., Jain, Dhanpat, Jhala, Nirag, Jorda, Merce, Jorns, Julie M., Kaplan, Jeffrey, Khalifa, Mahmoud A., Khan, Ashraf, Kim, Grace E., Lee, Eun Y., LiVolsi, Virginia A., Longacre, Teri, Magi-Galluzzi, Cristina, McCall, Shannon J., McPhaul, Laron, Mehta, Vikas, Merzianu, Mihai, Miller, Stacey B., Molberg, Kyle H., Moreira, Andre L., Naini, Bita V., Nosé, Vania, O’Toole, Kathleen, Picken, Maria, Prieto, Victor G., Pullman, James M., Quick, Charles M., Reynolds, Jordan P., Rosenberg, Andrew E., Schnitt, Stuart J., Schwartz, Mary R., Sekosan, Marin, Smith, Michael T., Sohani, Aliyah, Stowman, Anne, Vanguri, Vijay K., Wang, Beverly, Watts, John C., Wei, Shi, Whitney, Kathleen, Younes, Mamoun, Zee, Sui, and Bracamonte, Erika R.

Published
2022
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78. Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series

Author

Straub Hogan, Melissa M., Spieker, Andrew J., Orejudos, Michael, Gheit, Tarik, Herfs, Michael, Tommasino, Massimo, Sanchez, Diego F., Fernandez-Nestosa, Maria Jose, Pena, Maria Del Carmen Rodriguez, Gordetsky, Jennifer B., Epstein, Jonathan I., Canete-Portillo, Sofia, Gellert, Lan L., Prieto Granada, Carlos Nicolas, Magi-Galluzzi, Cristina, Cubilla, Antonio L., and Giannico, Giovanna A.

Published
2022
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85. Forecasting Polarized Radio Sources for CMB observations

Author

Puglisi, G., Galluzzi, V., Bonavera, L., Gonzalez-Nuevo, J., Lapi, A., Massardi, M., Perrotta, F., Baccigalupi, C., Celotti, A., and Danese, L.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We combine the latest datasets obtained with different surveys to study the frequency dependence of polarized emission coming from Extragalactic Radio Sources (ERS). We consider data over a very wide frequency range starting from $1.4$ GHz up to $217$ GHz. This range is particularly interesting since it overlaps the frequencies of the current and forthcoming Cosmic Microwave Background (\cmb) experiments. Current data suggest that at high radio frequencies, ($ \nu \geq 20$ GHz) the fractional polarization of ERS does not depend on the total flux density. Conversely, recent datasets indicate a moderate increase of polarization fraction as a function of frequency, physically motivated by the fact that Faraday depolarization is expected to be less relevant at high radio-frequencies. We compute ERS number counts using updated models based on recent data, and we forecast the contribution of unresolved ERS in CMB polarization spectra. Given the expected sensitivities and the observational patch sizes of forthcoming \cmb\ experiments about $\sim 200 $ ( up to $\sim 2000 $ ) polarized ERS are expected to be detected. Finally, we assess that polarized ERS can contaminate the cosmological B-mode polarization if the tensor-to-scalar ratio is $r< 0.05$ and they have to be robustly controlled to de-lens \cmb\ B-modes at the arcminute angular scales., Comment: 14 pages, 14 figures, 6 tables; AAS received 26th December,2017

Published
2017
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86. Average fractional polarization of extragalactic sources at Planck frequencies

Author

Trombetti, T., Burigana, C., De Zotti, G., Galluzzi, V., and Massardi, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Recent detailed simulations have shown that an insufficiently accurate characterization of the contamination of unresolved polarized extragalactic sources can seriously bias measurements of the primordial cosmic microwave background (CMB) power spectrum if the tensor-to-scalar ratio $r\sim 0.001,$ as predicted by models currently of special interest (e.g., Starobinsky's $R^2$ and Higgs inflation). This has motivated a reanalysis of the median polarization fraction of extragalactic sources (radio-loud AGNs and dusty galaxies) using data from the \textit{Planck} polarization maps. Our approach, exploiting the intensity distribution analysis, mitigates or overcomes the most delicate aspects of earlier analyses based on stacking techniques. By means of simulations, we have shown that the residual noise bias on the median polarization fraction, $\Pi_{\rm median}$, of extragalactic sources is generally $\simlt 0.1\%$. For radio sources, we have found $\Pi_{\rm median} \simeq 2.83\%$, with no significant dependence on either frequency or flux density, in good agreement with the earlier estimate and with high-sensitivity measurements in the frequency range 5--40\,GHz. No polarization signal is detected in the case of dusty galaxies, implying 90\% confidence upper limits of $\Pi_{\rm dusty}\simlt 2.2\%$ at 353\,GHz and of $\simlt 3.9\%$ at 217\,GHz. The contamination of CMB polarization maps by unresolved point sources is discussed., Comment: 10 pages, 3 figures, 7 tables; revised version. In press on Astronomy and Astrophysics

Published
2017
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87. Characterization of polarimetric and total intensity behaviour of a complete sample of PACO radio sources in the radio bands

Author

Galluzzi, Vincenzo, Massardi, Marcella, Bonaldi, Anna, Casasola, Viviana, Gregorini, Loretta, Trombetti, Tiziana, Burigana, Carlo, Bonato, Matteo, De Zotti, Gianfranco, Ricci, Roberto, Stevens, Jamie, Ekers, Ronald David, Bonavera, Laura, Alighieri, Sperello di Serego, Liuzzo, Elisabetta, Lopez-Caniego, Marcos, Paladino, Rosita, Toffolatti, Luigi, Tucci, Marco, and Callingham, Joseph Russell

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present high sensitivity ($\sigma_P \simeq 0.6\,$mJy) polarimetric observations in seven bands, from $2.1$ to $38\,$GHz, of a complete sample of $104$ compact extragalactic radio sources brighter than $200\,$mJy at $20\,$GHz. Polarization measurements in six bands, in the range $5.5-38\,$GHz, for $53$ of these objects were reported by \citet{Galluzzi2017}. We have added new measurements in the same six bands for another 51 sources and measurements at $2.1\,$GHz for the full sample of $104$ sources. Also, the previous measurements at $18$, $24$, $33$ and $38\,$GHz were re-calibrated using the updated model for the flux density absolute calibrator, PKS1934-638, not available for the earlier analysis. The observations, carried out with the Australia Telescope Compact Array (ATCA), achieved a $90\%$ detection rate (at $5\sigma$) in polarization. $89$ of our sources have a counterpart in the $72$ to $231\,$MHz GLEAM survey \citep{HurleyWalker2017}, providing an unparalleled spectral coverage of $2.7$ decades of frequency for these sources. While the total intensity data from $5.5$ to $38\,$GHz could be interpreted in terms of single component emission, a joint analysis of more extended total intensity spectra presented here, and of the polarization spectra, reveals that over $90\%$ of our sources show clear indications of at least two emission components. We interpret this as an evidence of recurrent activity. Our high sensitivity polarimetry has allowed a $5\,\sigma$ detection of the weak circular polarization for $\sim 38\%$ of the dataset, and a deeper estimate of $20\,$GHz polarization source counts than has been possible so far., Comment: 18 pages, 7 figures, accepted in MNRAS

Published
2017
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88. Brauer groups of 1-motives

Author

Bertolin, Cristiana and Galluzzi, Federica

Subjects
Mathematics - Algebraic Geometry, Mathematics - Number Theory, 14F22, 16H05
Abstract

Over a normal base scheme, we prove the generalized Theorem of the Cube for 1-motives and that a torsion class of the group H^2_\'et(M,G_m)$ of a 1-motive M, whose pull-back via the unit section is zero, comes from an Azumaya algebra. In particular, we deduce that over an algebraically closed field of characteristic zero, all classes of H^2_\'et(M,G_m) come from Azumaya algebras., Comment: final version

Published
2017

92. Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases

Author

Farcaş, Mihaela, Gatalica, Zoran, Trpkov, Kiril, Swensen, Jeffrey, Zhou, Ming, Alaghehbandan, Reza, Williamson, Sean R., Magi-Galluzzi, Cristina, Gill, Anthony J., Tretiakova, Maria, Lopez, Jose I., Montiel, Delia Perez, Sperga, Maris, Comperat, Eva, Brimo, Fadi, Yilmaz, Asli, Siadat, Farshid, Sangoi, Ankur, Gao, Yuan, Ptákova, Nikola, Kuthi, Levente, Pivovarcikova, Kristyna, Rogala, Joanna, Agaimy, Abbas, Hartmann, Arndt, Fraune, Cristoph, Rychly, Boris, Hurnik, Pavel, Durcansky, Dušan, Bonert, Michael, Gakis, Georgios, Michal, Michal, Hora, Milan, and Hes, Ondrej

Published
2022
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93. Utility of Pathology Imagebase for standardisation of prostate cancer grading.

Author

Egevad, Lars, Delahunt, Brett, Berney, Daniel, Bostwick, David, Cheville, John, Comperat, Eva, Evans, Andrew, Fine, Samson, Grignon, David, Humphrey, Peter, Hörnblad, Jonas, Iczkowski, Kenneth, Kench, James, Kristiansen, Glen, Leite, Katia, Magi-Galluzzi, Cristina, McKenney, Jesse, Oxley, Jon, Pan, Chin-Chen, Samaratunga, Hemamali, Srigley, John, Takahashi, Hiroyuki, True, Lawrence, Tsuzuki, Toyonori, van der Kwast, Theo, Varma, Murali, Zhou, Ming, and Clements, Mark

Subjects
International Society of Urological Pathology, database, grading, prostate, standardisation, Databases, Factual, Humans, Male, Neoplasm Grading, Pathology, Clinical, Prostatic Neoplasms
Abstract

AIMS: Despite efforts to standardise grading of prostate cancer, even among experts there is still a considerable variation in grading practices. In this study we describe the use of Pathology Imagebase, a novel reference image library, for setting an international standard in prostate cancer grading. METHODS AND RESULTS: The International Society of Urological Pathology (ISUP) recently launched a reference image database supervised by experts. A panel of 24 international experts in prostate pathology reviewed independently microphotographs of 90 cases of prostate needle biopsies with cancer. A linear weighted kappa of 0.67 (95% confidence interval = 0.62-0.72) and consensus was reached in 50 cases. The interobserver weighted kappa varied from 0.48 to 0.89. The highest level of agreement was seen for Gleason score (GS) 3 + 3 = 6 (ISUP grade 1), while higher grades and particularly GS 4 + 3 = 7 (ISUP grade 3) showed considerable disagreement. Once a two-thirds majority was reached, images were moved automatically into a public database available for all ISUP members at www.isupweb.org. Non-members are able to access a limited number of cases. CONCLUSIONS: It is anticipated that the database will assist pathologists to calibrate their grading and, hence, decrease interobserver variability. It will also help to identify instances where definitions of grades need to be clarified.

Published
2018

94. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Author

Galluzzi, Lorenzo, Vitale, Ilio, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Annicchiarico-Petruzzelli, Margherita, Antonov, Alexey V, Arama, Eli, Baehrecke, Eric H, Barlev, Nickolai A, Bazan, Nicolas G, Bernassola, Francesca, Bertrand, Mathieu JM, Bianchi, Katiuscia, Blagosklonny, Mikhail V, Blomgren, Klas, Borner, Christoph, Boya, Patricia, Brenner, Catherine, Campanella, Michelangelo, Candi, Eleonora, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chandel, Navdeep S, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Cohen, Gerald M, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D’Angiolella, Vincenzo, Dawson, Ted M, Dawson, Valina L, De Laurenzi, Vincenzo, De Maria, Ruggero, Debatin, Klaus-Michael, DeBerardinis, Ralph J, Deshmukh, Mohanish, Di Daniele, Nicola, Di Virgilio, Francesco, Dixit, Vishva M, Dixon, Scott J, Duckett, Colin S, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Fimia, Gian Maria, Fulda, Simone, García-Sáez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Golstein, Pierre, Gottlieb, Eyal, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Gross, Atan, Hajnoczky, Gyorgy, Hardwick, J Marie, Harris, Isaac S, Hengartner, Michael O, Hetz, Claudio, Ichijo, Hidenori, Jäättelä, Marja, Joseph, Bertrand, Jost, Philipp J, Juin, Philippe P, Kaiser, William J, Karin, Michael, Kaufmann, Thomas, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Knight, Richard A, Kumar, Sharad, Lee, Sam W, Lemasters, John J, Levine, Beth, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Lowe, Scott W, Luedde, Tom, Lugli, Enrico, MacFarlane, Marion, Madeo, Frank, Malewicz, Michal, Malorni, Walter, and Manic, Gwenola

Subjects
Biochemistry and Cell Biology, Biological Sciences, Animals, Cell Death, Humans, Lysosomes, Mitochondrial Membrane Transport Proteins, Mitochondrial Permeability Transition Pore, Necrosis, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Published
2018

95. Surface Exospheric Interactions

Author

Teolis, Ben, Sarantos, Menelaos, Schorghofer, Norbert, Jones, Brant, Grava, Cesare, Mura, Alessandro, Prem, Parvathy, Greenhagen, Ben, Capria, Maria Teresa, Cremonese, Gabriele, Lucchetti, Alice, and Galluzzi, Valentina

Published
2023
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