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963 results on '"GILLET, M."'

78. Morale

Author

Gillet, M. S.

Published
1912

79. MORALE

Author

Gillet, M. S.

Published
1913

82. MORALE

Author

Gillet, M.-S.

Published
1914

84. MORALE

Author

Gillet, M. S.

Published
1911

87. MORALE

Author

Gillet, M. S.

Published
1909

90. MORALE

Author

Gillet, M.

Published
1907

91. MORALE

Author

Gillet, M. S.

Published
1908

93. MORALE

Author

Gillet, M. S.

Published
1920

95. Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients

Author

Peters, S., Voelter, V., Zografos, L., Pampallona, S., Popescu, R., Gillet, M., Bosshard, W., Fiorentini, G., Lotem, M., Weitzen, R., Keilholz, U., Humblet, Y., Piperno-Neumann, S., Stupp, R., Leyvraz, S., Peters, S., Voelter, V., Zografos, L., Pampallona, S., Popescu, R., Gillet, M., Bosshard, W., Fiorentini, G., Lotem, M., Weitzen, R., Keilholz, U., Humblet, Y., Piperno-Neumann, S., Stupp, R., and Leyvraz, S.

Abstract

Background: Exclusive liver metastases occur in up to 40% of patients with uveal melanoma associated with a median survival of 2-7 months. Single agent response rates with commonly available chemotherapy are below 10%. We have investigated the use of fotemustine via direct intra-arterial hepatic (i.a.h.) administration in patients with uveal melanoma metastases. Patients and methods: A total of 101 patients from seven centers were treated with i.a.h. fotemustine, administered intra-arterially weekly for a 4-week induction period, and then as a maintenance treatment every 3 weeks until disease progression, unacceptable toxicity or patient refusal. Results: A median of eight fotemustine infusions per patient were delivered (range 1-26). Catheter related complications occurred in 23% of patients; however, this required treatment discontinuation in only 10% of the patients. The overall response rate was 36% with a median overall survival of 15 months and a 2-year survival rate of 29%. LDH, time between diagnosis and treatment start and gender were significant predictors of survival. Conclusions: Locoregional treatment with fotemustine is well tolerated and seems to improve outcome of this poor prognosis patient population. Median survival rates are among the longest reported and one-third of the patients are still alive at 2 years

Published
2017

98. Innovation sociale et multiplicité des frontières : les apports du programme de recherche-action Proximam-Lotharingie 2

Author

Balzani, Bernard, Deshayes, Jean-Luc, Gillet, M, Lhuillier, Vincent, Rihoux, J, Laboratoire Lorrain de Sciences Sociales (2L2S), Université de Lorraine (UL), Jean-Pascal Higelé, Vincent Lhuillier, and UL, 2L2S

Subjects
[SHS] Humanities and Social Sciences, [SHS]Humanities and Social Sciences
Abstract

Colloque international pluridisciplinaire et plurisectoriel «Les recherches-actions collaboratives : une révolution silencieuse de la connaissance» , Dijon, 27 & 28 mai 2013; International audience

Published
2014

100. Relationships between in vitro lymphoproliferative responses and levels of contaminants in blood of free-ranging adult harbour seals (Phoca vitulina) from the North Sea

Author

Dupont, A., Siebert, U., Covaci, A., Weijs, L., Eppe, G., Debier, C., De Pauw-Gillet, M.-C., and Das, K.

Subjects
Blood, In vitro, Contaminants, Phoca vitulina
Abstract

In vitro culture of peripheral blood leucocytes (PBLs) is currently used in toxicological studies of marine mammals. However, blood cells of wild individuals are exposed in vivo to environmental contaminants before being isolated and exposed to contaminants in vitro. The aim of this study was to highlight potential relationships between blood contaminant levels and in vitro peripheral blood lymphocyte proliferation in free-ranging adult harbour seals (Phoca vitulina) from the North Sea. Blood samples of 18 individuals were analyzed for trace elements (Fe, Zn, Se, Cu, Hg, Pb, Cd) and persistent organic contaminants and metabolites (SPCBs, SHO-PCBs, SPBDEs, 2-MeO-BDE68 and 6-MeO-BDE47, SDDXs, hexachlorobenzene, oxychlordane, trans-nonachlor, pentachlorophenol and tribromoanisole). The same samples were used to determine the haematology profiles, cell numbers and viability, as well as the in vitro ConA-induced lymphocyte proliferation expressed as a stimulation index (SI). Correlation tests (Bravais-Pearson) and Principal Component Analysis with multiple regression revealed no statistically significant relationship between the lymphocyte SI and the contaminants studied. However, the number of lymphocytes per millilitre of whole blood appeared to be negatively correlated to pentachlorophenol (r = -0.63, p = 0.005). In adult harbour seals, the interindividual variations of in vitro lymphocyte proliferation did not appear to be directly linked to pollutant levels present in the blood, and it is likely that other factors such as age, life history, or physiological parameters have an influence. In a general manner, experiments with in vitro immune cell cultures of wild marine mammals should be designed so as to minimize confounding factors in which case they remain a valuable tool to study pollutant effects in vitro.

Published
2013

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