279 results on '"G. Lavigne"'
Search Results
52. Chapter 4 Reactivities of Metal Clusters
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G. Lavigne and H.D. Kaesz
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chemistry.chemical_compound ,chemistry ,Ligand ,High selectivity ,Cluster (physics) ,Organic chemistry ,Organic synthesis ,Reactivity (chemistry) ,Combinatorial chemistry ,Metal clusters ,Catalysis - Abstract
Publisher Summary This chapter emphasizes the aspects of cluster reactivity that have relevance to catalysis. The pathways available to cluster complexes for coordination of substrates (reactants) are discussed. Cluster complexes possessing low-energy activation pathways leading to reactions with high selectivity in the products are found. Except for the few cases of cluster complexes that are electronically unsaturated, reactivity of a cluster requires activation by some means. This is usually achieved by loss of ligand or by opening of a metal-metal bond. Catalytic activation of saturated cluster complexes that are otherwise either unreactive or poorly reactive under mild conditions has recently been discovered. The chapter presents the recently discovered means to enhance the reactivity of cluster complexes. To illustrate possibilities and limits to the use of cluster complexes as synthetic tools for organic synthesis and catalysis, the cluster-assisted transformations of organic substrates are analyzed.
- Published
- 1986
53. [Treatment of severe chronic cardiac insufficiency with dihydralazine. Short-and median-term results]
- Author
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P, Morand, G, Lavigne, D, Masson, F, Latour, and D, Alison
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Adult ,Heart Failure ,Male ,Chronic Disease ,Administration, Oral ,Drug Evaluation ,Humans ,Female ,Middle Aged ,Hydralazine ,Dihydralazine ,Aged - Abstract
17 patients with severe chronic heart failure (class III and IV) were prescribed hydralazine, an arterial vasodilatator, orally at doses of 150 mg to 400 mg/day. Considerable clinical improvement was observed in most patients. After 24 to 48 hours the cardiac index rose 79 p. 100, the systolic index by 67 p. 100 and left ventricular work by 73 p. 100, whilst systemic and pulmonary resistances fell by 51 p. 100 and 34 p. 100 respectively. There was no significant change in systemic blood pressure or in heart rate. These results were confirmed at 4 months. Mean pulmonary capillary pressure varied little at the start of treatment but decreased by 52 p. 100 at medium term (4 and 12 months) in this series. No cases of systemic lupus erythematosis were observed. The main, but not the only, indication of therapy with dihydralazine is low output heart failure with little elevation in the pulmonary capillary pressure, especially in primary cardiomyopathy and valvular regurgitation. At present, treatment should be based on the results of cardiac catheterisation and the dosage adjusted according to the rate of hepatic acetylation.
- Published
- 1979
54. The use of electronic devices in the diagnosis and treatment of temporomandibular disorders
- Author
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J P, Lund, G, Lavigne, J S, Feine, J P, Goulet, D V, Chaytor, B J, Sessle, G, Zarb, L F, Greenwood, A G, Hannam, and W W, Wood
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Humans ,Temporomandibular Joint Disorders ,Temporomandibular Joint Dysfunction Syndrome ,Electronics, Medical - Published
- 1989
55. [Tolerance and complications of the treatment of severe heart failure by dihydralazine]
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P, Morand and G, Lavigne
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Heart Failure ,Male ,Humans ,Middle Aged ,Hydralazine ,Dihydralazine - Published
- 1980
56. [The effect of cancer on drug metabolism and drug action]
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J G, Lavigne
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Mice ,Intestinal Absorption ,Liver ,Pharmaceutical Preparations ,Depression, Chemical ,Neoplasms ,Liver Neoplasms ,Animals ,Humans ,In Vitro Techniques ,Biotransformation ,Neoplasm Staging ,Rats - Abstract
Over the last few years, numerous studies performed mainly in animals with a tumour but also in man with malignant disease have shown that the presence of cancer modifies gastro-intestinal absorption, tissue distribution and transformation of drugs in the liver. Consequently, malignant disease also influences the therapeutic effects and toxic effects of drugs. This effect may occur with several drugs, with or without antineoplastic properties, and appears mainly at an advanced stage of the disease.
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- 1977
57. [The treatment of severe chronic cardiac failure by dihydralazine]
- Author
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P, Morand, G, Lavigne, D, Masson, and F, Latour
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Adult ,Male ,Heart Diseases ,Chronic Disease ,Humans ,Middle Aged ,Hydralazine ,Dihydralazine ,Aged - Published
- 1978
58. ChemInform Abstract: EFFECTS OF HIGHLY DISSOCIATED SALTS IN STOICHIOMETIC AND CATALYTIC REACTIONS ON RUTHENIUM CLUSTER COMPLEXES
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G. LAVIGNE and H. D. KAESZ
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General Medicine - Published
- 1984
59. [Results of the treatment of heart failure with captopril]
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P, Morand and G, Lavigne
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Heart Failure ,Male ,Captopril ,Proline ,Hemodynamics ,Humans ,Female ,Middle Aged - Published
- 1981
60. ChemInform Abstract: UNUSUAL SULFUR INSERTION IN A COPPER(I)-MERCAPTOBENZOTHIAZOLE COMPLEX: SYNTHESIS AND STRUCTURAL STUDY OF (CUI(C7H5NS2)(C14H8N2S5))(CLO4).2CHCL3
- Author
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Yves Jeannin, S. Jeannin, and G. Lavigne
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chemistry ,Polymer chemistry ,chemistry.chemical_element ,Mercaptobenzothiazole ,General Medicine ,Copper ,Sulfur - Published
- 1980
61. [Antineoplastic drugs: resistance and metabolism]
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J G, Lavigne
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Neoplasms ,Drug Resistance ,Humans ,Antineoplastic Agents ,Biotransformation - Published
- 1976
62. [Iatrogenic arteriovenous fistula from the internal mammary artery. Spontaneous closure]
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P, Morand, D, Masson, B, Charbonnier, G, Lavigne, and J, Brehier
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Adult ,Sternum ,Thoracic Arteries ,Vena Cava, Superior ,Arteriovenous Fistula ,Iatrogenic Disease ,Humans ,Female ,Breast ,Mammary Arteries ,Catheterization - Abstract
Two cases of arteriovenous fistula arising from the internal mammary artery are described. The detection of the continuous subclavian murmur was preceded by therapeutic procedures in both cases; difficult subclavian vein catheterisation in the first; reoperation of sternotomy for postoperative haemorrhage after open heart mitral commissurotomy in the second. Oxymetry after sampling at, above and below the subclavian vein confirmed the presence of a shunt and allowed estimation of shunt flow, which was minimal in both cases, 11 and 32% of cardiac output respectively. The origin of the fistula at the internal mammary artery and the communicating vein were identified by semi-selective angiography. The latter was superior vena cava in the first case and the internal mammary vein in the second. The low shunt flow probably explains the outcome: spontaneous closure in both cases. This is exceptional in any form of arteriovenous fistula.
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- 1981
63. [Influence of disease on the metabolism and effects of drugs in man]
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J G, Lavigne
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Heart Diseases ,Intestinal Absorption ,Pharmaceutical Preparations ,Liver Diseases ,Neoplasms ,Humans ,Kidney Diseases ,Biotransformation ,Protein Binding - Published
- 1980
64. Characterization of thin film PLZT for spatial light modulator applications
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R. Carter, M. Ivey, S. Mancha, and G. Lavigne
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3D optical data storage ,Materials science ,Spatial light modulator ,genetic structures ,business.industry ,Photoconductivity ,Optical storage ,Ferroelectricity ,eye diseases ,Hysteresis ,Optics ,Sputtering ,Optoelectronics ,sense organs ,Thin film ,business - Abstract
PLZT thin films were characterized for possible use in spatial light modulator applications. Photocurrents, photosensitivity, and hysteresis characteristics were measured. Optical data were stored in the films and read out using scanning techniques. On the basis of the results and previous work, these thin films show promise for applications to spatial light modulators. >
65. Potentiation of morphine analgesia by proglumide for acute clinical pain
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Kenneth M. Hargreaves, G. Lavigne, E. S. Schmidt, Gregory P. Mueller, and Raymond A. Dionne
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Anesthesiology and Pain Medicine ,Proglumide ,Neurology ,business.industry ,Anesthesia ,Clinical pain ,medicine ,Long-term potentiation ,Neurology (clinical) ,business ,Morphine analgesia ,medicine.drug - Published
- 1987
66. THE ROLE OF METABOLISM IN CHLOROFORM HEPATGTOXICITY
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C Marchand and J. G. Lavigne
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chemistry.chemical_compound ,Chloroform ,Biochemistry ,chemistry ,business.industry ,Medicine ,Metabolism ,business - Published
- 1975
67. Hypertrophic obstructive cardiomyopathy (H.O.C.): Comparaison of hemodynamics effects of verapamil (V.) 480 mg/24 h versus propranolol (P.) 320 mg/24 h
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G. Lavigne, Pierre Cosnay, Jean Paul Fauchier, Ph. Raynaud, and Quilliet L
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Cardiology ,Verapamil ,Hemodynamics ,Propranolol ,Cardiology and Cardiovascular Medicine ,business ,Molecular Biology ,Obstructive cardiomyopathy ,medicine.drug - Published
- 1984
68. Moving beyond bruxism episode index: Discarding misuse of the number of sleep bruxism episodes as masticatory muscle pain biomarker.
- Author
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Wieckiewicz M, Martynowicz H, Lavigne G, Kato T, Lobbezoo F, Smardz J, Ahlberg J, Winocur E, Emodi-Perlman A, Restrepo C, Wojakowska A, Gac P, Mazur G, Waliszewska-Prosol M, Swienc W, and Manfredini D
- Abstract
The objective of the current study was to evaluate the clinical utility of bruxism episode index in predicting the level of masticatory muscle pain intensity. The study involved adults (n = 220) recruited from the Outpatient Clinic of Temporomandibular Disorders at the Department of Experimental Dentistry, Wroclaw Medical University, during the period 2017-2022. Participants underwent medical interview and dental examination, focusing on signs and symptoms of sleep bruxism. The intensity of masticatory muscle pain was gauged using the Numeric Rating Scale. Patients identified with probable sleep bruxism underwent further evaluation through video-polysomnography. Statistical analyses included the Shapiro-Wilk test, Spearman's rank correlation test, association rules, receiver operating characteristic curves, linear regression, multivariate regression and prediction accuracy analyses. The analysis of correlation and one-factor linear regression revealed no statistically significant relationships between bruxism episode index and Numeric Rating Scale (p > 0.05 for all analyses). Examination of receiver operating characteristic curves and prediction accuracy indicated a lack of predictive utility for bruxism episode index in relation to masticatory muscle pain intensity. Multivariate regression analysis demonstrated no discernible relationship between bruxism episode index and Numeric Rating Scale across all examined masticatory muscles. In conclusion, bruxism episode index and masticatory muscle pain intensity exhibit no correlation, and bruxism episode index lacks predictive value for masticatory muscle pain. Clinicians are advised to refrain from employing the frequency of masticatory muscle activity as a method for assessing the association between masticatory muscle pain and sleep bruxism., (© 2024 The Author(s). Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)
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- 2024
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69. Motivation to regulate eating behaviors, intuitive eating, and well-being: A dyadic study with mothers and adult daughters.
- Author
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Holding A, Lavigne G, Vermette L, and Carbonneau N
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- Humans, Female, Adult, Adult Children psychology, Middle Aged, Young Adult, Nuclear Family psychology, Eating psychology, Motivation, Feeding Behavior psychology, Mothers psychology, Intuition, Mother-Child Relations psychology
- Abstract
Intuitive eating, defined as relying on physiological cues to determine when, what, and how much to eat while maintaining a positive relationship with food (Tribole & Resch, 1995), has gained a lot of research attention in the last two decades. The present study sought to determine how motivation for regulating eating behaviors is related to intuitive eating and well-being outcomes in dyads of mothers and their adult daughters (n = 214). Structural equation modelling revealed that controlling for dieting and desire to lose weight, both mothers' and daughters' autonomous motivation was positively associated with their own intuitive eating while their controlled motivation was negatively associated with intuitive eating. In turn, intuitive eating was positively associated with well-being in both mothers and daughters. Interestingly, mothers' intuitive eating was also positively related to their daughters' well-being. The analysis of indirect effects suggests that mothers' motivation to regulate eating behaviors has an indirect (mediating) relationship with daughters' well-being through mothers' intuitive eating. The implications for women's health and well-being are discussed., Competing Interests: Declaration of competing interest All authors have no interest to declare., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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70. A case-control study on the effect of rhythmic masticatory muscle activity (RMMA) clusters on sleep fragmentation and severity of orofacial muscle pain in sleep bruxism.
- Author
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Martynowicz H, Lavigne G, Kato T, Poreba R, Michalek-Zrabkowska M, Macek P, Gac P, Wojakowska A, Surowiak P, Mazur G, and Wieckiewicz M
- Subjects
- Humans, Male, Female, Adult, Case-Control Studies, Middle Aged, Severity of Illness Index, Electromyography, Sleep Bruxism physiopathology, Sleep Bruxism complications, Masticatory Muscles physiopathology, Polysomnography, Facial Pain physiopathology, Facial Pain etiology, Sleep Deprivation physiopathology
- Abstract
Rhythmic masticatory muscle activity (RMMA) is a periodic muscle activity that characterises sleep bruxism (SB) events. These can occur as a single event, in pairs, or in clusters. Since RMMA episodes often occur in clusters and the relevance of this occurrence is unknown, we conducted a study to investigate the effect of RMMA clusters on sleep fragmentation and the severity of orofacial muscle pain. This study involved a secondary analysis using data from 184 adult subjects with orofacial muscle pain who underwent definitive polysomnography (PSG) for sleep bruxism diagnosis. Self-reported orofacial muscle pain (OFMP) was assessed using the numeric rating scale, and additional evaluation of side-to-side equivalence (symmetry) was described using a binary system. Among the 184 participants, 60.8% (n = 112) did not exhibit clusters and among the 72 participants with clusters, 36.1% (n = 26) and 63.9% (n = 46) were in the high and low RMMA frequency groups, respectively. The high SB group had significantly three times more phasic RMMA events than the noncluster group. A total of 89.67% (n = 165) of subjects reported orofacial muscle pain. While there was no difference in the severity of OFMP among groups, a significant decrease in symmetry between the severity of temporal muscle pain on the left and right sides was noted in the cluster group compared with the noncluster group. Clustering of RMMA events is associated with sleep fragmentation. The asymmetry of temporal muscle pain is related to the presence of RMMA clusters in sleep bruxism., (© 2023 European Sleep Research Society.)
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- 2024
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71. Opioid prescribing requirements to minimize unused medications after an emergency department visit for acute pain: a prospective cohort study.
- Author
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Daoust R, Paquet J, Émond M, Iseppon M, Williamson D, Yan JW, Perry JJ, Huard V, Lavigne G, Lee J, Lessard J, Lang E, and Cournoyer A
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- Humans, Female, Male, Middle Aged, Prospective Studies, Adult, Aged, Drug Prescriptions statistics & numerical data, Abdominal Pain drug therapy, Renal Colic drug therapy, Practice Patterns, Physicians' statistics & numerical data, Fractures, Bone, Back Pain drug therapy, Emergency Room Visits, Analgesics, Opioid therapeutic use, Analgesics, Opioid administration & dosage, Emergency Service, Hospital, Acute Pain drug therapy
- Abstract
Background: Unused opioid prescriptions can be a driver of opioid misuse. Our objective was to determine the optimal quantity of opioids to prescribe to patients with acute pain at emergency department discharge, in order to meet their analgesic needs while limiting the amount of unused opioids., Methods: In a prospective, multicentre cohort study, we included consecutive patients aged 18 years and older with an acute pain condition present for less than 2 weeks who were discharged from emergency department with an opioid prescription. Participants completed a pain medication diary for real-time recording of quantity, doses, and names of all analgesics consumed during a 14-day follow-up period., Results: We included 2240 participants, who had a mean age of 51 years; 48% were female. Over 14 days, participants consumed a median of 5 (quartiles, 1-14) morphine 5 mg tablet equivalents, with significant variation across pain conditions ( p < 0.001). Most opioid tablets prescribed (63%) were unused. To meet the opioid need of 80% of patients for 2 weeks, we found that those experiencing renal colic or abdominal pain required fewer opioid tablets (8 morphine 5 mg tablet equivalents) than patients who had fractures (24 tablets), back pain (21 tablets), neck pain (17 tablets), or other musculoskeletal pain (16 tablets)., Interpretation: Two-thirds of opioid tablets prescribed at emergency department discharge for acute pain were unused, whereas opioid requirements varied significantly based on the cause of acute pain. Smaller, cause-specific opioid prescriptions could provide adequate pain management while reducing the risk of opioid misuse., Trial Registration: ClinicalTrials.gov, no. NCT03953534., Competing Interests: Competing interests:: Justin Yan reports receiving funding from the Spring 2021 Innovation Fund from the Academic Medical Organization of Southwestern Ontario, and the 2021 Internal Research Fund for Pilot Studies from the Lawson Health Research Institute. Dr. Yan has also served as the chair of the data safety monitoring boards of the RAFF4 Study and the REMOSYNCED Study, and vice-chair of the Canadian Association of the Emergency Physicians Research Committee. Jeffrey Perry reports receiving a peer review salary support grant from the Heart and Stroke Foundation of Ontario. Gilles Lavigne reports receiving consulting fees from Straumann Suisse related to a sleep bruxism device, and an oral appliance for sleep apnea from Panthera Dental. Dr. Lavigne is also a board member of the Canadian Academy of Health Sciences. No other competing interests were declared., (© 2024 CMA Impact Inc. or its licensors.)
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- 2024
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72. Validation of the French-Canadian Translation of the ecSatter Inventory 2.0 in an Adult Sample.
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Carbonneau É, Dumas AA, Drouin Rousseau S, Lavigne G, and Carbonneau N
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- Humans, Female, Male, Adult, Cross-Sectional Studies, Reproducibility of Results, Surveys and Questionnaires standards, Canada, Feeding Behavior, Middle Aged, Young Adult, Translations, Body Image psychology, Psychometrics
- Abstract
Objective: Evaluate the psychometric proprieties of the French-Canadian translation of the Satter Eating Competence Inventory (FrCanada ecSI 2.0)., Design: Cross-sectional validation study., Participants and Setting: 424 French-Canadian adult Facebook users (61.8% women, 96.0% White)., Variables Measured: Eating competence and variables related to eating or body image., Analysis: Factor analyses to assess the structural validity. Cronbach α and intraclass correlation coefficient to estimate reliability. Chi-square test of independence, Student t test, and Pearson's correlations to assess construct validity., Results: The mean eating competence score was 33.0 ± 7.8; 62.0% of participants were considered competent eaters (total score ≥ 32/48). The original 4-factor structure was not reproduced (unsatisfactory fit indices and/or factor loadings). Therefore, it is recommended to use the global score-but not the subscale scores-of the FrCanada ecSI 2.0. The questionnaire showed good internal consistency (Cronbach α = 0.86) and test-retest reliability (intraclass correlation = 0.81). Competent and noncompetent eaters differed according to gender (39.5% vs 27.3% male; P = 0.03), age (49.3 ± 13.6 vs 42.7 ± 14.2 years; P < 0.01), education (62.3% vs 50.6% with a university degree; P = 0.03), intuitive eating (3.6 ± 0.5 vs 3.1 ± 0.6; P < 0.001), cognitive restraint (12.3 ± 3.3 vs 13.8 ± 3.7; P < 0.001), and body esteem (3.3 ± 0.8 vs 2.5 ± 0.8; P < 0.001)., Conclusion and Implications: Results suggest that the FrCanada ecSI 2.0 is a valid and reliable tool to measure eating competence in French-Canadian adults., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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73. Erectile dysfunction and sleep related bruxism: An exploratory review of an improbable association.
- Author
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Andersen ML, Lavigne G, Dal Fabbro C, and Tufik S
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- Humans, Male, Prevalence, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive epidemiology, Sleep Apnea, Obstructive physiopathology, Sleep Bruxism complications, Erectile Dysfunction epidemiology, Erectile Dysfunction etiology
- Abstract
The World Health Organization recognizes sexual health as not merely the absence of disease, but a state of physical, mental, and social well-being in relation to one's sexuality. Achieving sexual satisfaction is pivotal for many individuals, as it significantly contributes to their quality of life. Among various sexual disorders, erectile dysfunction (ED) is notably prevalent, affecting an estimated 10-20 million men in the United States alone. This condition impacts not just the person experiencing it but also significantly influences their intimate connections with partners. Although the causes of ED are multifactorial, recent research highlights a compelling association between sleep disorders, such as sleep deprivation, obstructive sleep apnea (OSA), and insomnia, and the incidence of ED. Furthermore, engaging in night work has been observed to exacerbate the risk of developing ED. One common sleep disorder, sleep related bruxism (SRB), despite its prevalence, has not generally been associated with ED. However, there is some interesting evidence hinting at a potential relationship, including a few studies reporting a high prevalence of ED in individuals with SRB. This review delves into the epidemiological, etiological, and mechanistic links between ED and SRB, aiming to uncover potential intersections between these two conditions. These insights could pave the way for innovative research avenues, possibly exploring treatments like vasodilation medication, that might concurrently address both ED and SRB., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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74. Efficacy and Safety Analyses of Recombinant Factor VIIa in Severe Post-Partum Hemorrhage.
- Author
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Caram-Deelder C, McKinnon Edwards H, Zdanowicz JA, van den Akker T, Birkegård C, Blatný J, van der Bom JG, Colucci G, van Duuren D, van Geloven N, Henriquez DDCA, Knight M, Korsholm L, Landorph A, Lavigne Lissalde G, McQuilten ZK, Surbek D, Wellard C, Wood EM, and Mercier FJ
- Abstract
Background : Despite a range of available treatments, it is still sometimes challenging to treat patients with severe post-partum hemorrhage (sPPH). Objective: This study evaluated the efficacy and safety of recombinant activated factor VIIa (rFVIIa) in sPPH management. Methods : An open-label, multi-center, randomized controlled trial (RCT; NCT00370877) and four observational studies (OS; OS-1 (NCT04723979), OS-2, OS-3, and OS-4) were analyzed regarding efficacy (need for subsequent invasive procedures, including uterine compression sutures, uterine or iliac artery ligations, arterial embolization, or hysterectomy) and safety (incidence of thromboembolic events (TE) and maternal mortality) of rFVIIa for sPPH. The RCT, and OS-1 and OS-2, included a control group of women who did not receive rFVIIa (with propensity score-matching used in OS-1 and OS-2), whereas OS-3 and OS-4 provided descriptive data for rFVIIa-exposed women only. Results : A total of 446 women exposed to rFVIIa and 1717 non-exposed controls were included. In the RCT, fewer rFVIIa-exposed women (50% [21/42]) had an invasive procedure versus non-exposed women (91% [38/42]; odds ratio: 0.11; 95% confidence interval: 0.03-0.35). In OS-1, more rFVIIa-exposed women (58% [22/38]) had an invasive procedure versus non-exposed women (35% [13.3/38]; odds ratio: 2.46; 95% confidence interval: 1.06-5.99). In OS-2, 17% (3/18) of rFVIIa-exposed women and 32% (5.6/17.8) of non-exposed women had an invasive procedure (odds ratio: 0.33; 95% confidence interval: 0.03-1.75). Across all included women, TEs occurred in 1.5% (0.2% arterial and 1.2% venous) of rFVIIa-exposed women and 1.6% (0.2% arterial and 1.4% venous) of non-exposed women with available data. Conclusions : The positive treatment effect of rFVIIa on the RCT was not confirmed in the OS. However, the safety analysis did not show any increased incidence of TEs with rFVIIa treatment.
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- 2024
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75. Mandibular Jaw Movement Automated Analysis for Oral Appliance Monitoring in Obstructive Sleep Apnea: A Prospective Cohort Study.
- Author
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Pépin JL, Cistulli PA, Crespeigne E, Tamisier R, Bailly S, Bruwier A, Le-Dong NN, Lavigne G, Malhotra A, and Martinot JB
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- Humans, Prospective Studies, Male, Female, Middle Aged, Adult, Mandible, Aged, Continuous Positive Airway Pressure instrumentation, Continuous Positive Airway Pressure methods, Movement, Monitoring, Physiologic methods, Monitoring, Physiologic instrumentation, Sleep Apnea, Obstructive therapy, Sleep Apnea, Obstructive diagnosis, Polysomnography
- Abstract
Rationale: Oral appliances are second-line treatments after continuous positive airway pressure for obstructive sleep apnea (OSA) management. However, the need for oral appliance titration limits their use as a result of monitoring challenges to assess the treatment effect on OSA. Objectives: To assess the validity of mandibular jaw movement (MJM) automated analysis compared with polysomnography (PSG) and polygraphy (PG) in evaluating the effect of oral appliance treatment and the effectiveness of MJM monitoring for oral appliance titration at home in patients with OSA. Methods: This observational, prospective study included 135 patients with OSA eligible for oral appliance therapy. The primary outcome was the apnea-hypopnea index (AHI), measured through in-laboratory PSG/PG and MJM-based technology. Additionally, MJM monitoring at home was conducted at regular intervals during the titration process. The agreement between PSG/PG and MJM automated analysis was revaluated using Bland-Altman analysis. Changes in AHI during the home-based oral appliance titration process were evaluated using a generalized linear mixed model and a generalized estimating equation model. Results: The automated MJM analysis demonstrated strong agreement with PG in assessing AHI at the end of titration, with a median bias of 0.24/h (limits of agreement, -11.2 to 12.8/h). The improvement of AHI from baseline in response to oral appliance treatment was consistent across three evaluation conditions: in-laboratory PG (-59.6%; 95% confidence interval, -59.8% to -59.5%), in-laboratory automated MJM analysis (-59.2%; -65.2% to -52.2%), and at-home automated MJM analysis (-59.7%; -67.4% to -50.2%). Conclusions: Incorporating MJM automated analysis into the oral appliance titration process has the potential to optimize oral appliance therapy outcomes for OSA.
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- 2024
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76. The efficacy of occlusal "dental" equilibration in the management of sleep bruxism: Still an unsolved mystery.
- Author
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Kato T, Lobbezoo F, and Lavigne G
- Subjects
- Humans, Occlusal Splints, Sleep Bruxism diagnosis, Sleep Bruxism therapy, Bruxism
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- 2024
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77. Network analysis of sleep bruxism in the EPISONO adult general population.
- Author
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Chattrattrai T, Aarab G, Blanken TF, Pires GN, Herrero Babiloni A, Dal Fabbro C, van Someren E, Lavigne G, Maluly M, Andersen ML, Tufik S, and Lobbezoo F
- Subjects
- Adult, Humans, Brazil epidemiology, Polysomnography, Self Report, Sleep, Sleep Initiation and Maintenance Disorders epidemiology, Sleep Initiation and Maintenance Disorders complications, Sleep Bruxism epidemiology
- Abstract
Sleep bruxism (SB) has been associated with biological and psychosocial factors. The assessment of SB includes self-report, clinical evaluation, and polysomnography. This study aimed to investigate the associations of self-reported SB with other sleep disorders and demographic, psychological, and lifestyle factors in the adult general population, and to investigate whether self-reported SB and polysomnographically (PSG) confirmed SB provide similar outcomes in terms of their associated factors. We recruited 915 adults from the general population in Sao Paulo, Brazil. All participants underwent a one-night PSG recording and answered questions about sex, age, BMI, insomnia, OSA risk, anxiety, depression, average caffeine consumption, smoking frequency, and alcohol consumption frequency. We investigated the link between SB and the other variables in univariate, multivariate, and network models, and we repeated each model once with self-reported SB and once with PSG-confirmed SB. Self-reported SB was only significantly associated with sex (p = 0.042), anxiety (p = 0.002), and depression (p = 0.03) in the univariate analysis, and was associated with insomnia in the univariate (p < 0.001) and multivariate (β = 1.054, 95%CI 1.018-1.092, p = 0.003) analyses. Network analysis showed that self-reported SB had a direct positive edge to insomnia, while PSG-confirmed SB was not significantly associated with any of the other variables. Thus, sleep bruxism was positively associated with insomnia only when self-reported, while PSG-confirmed SB was not associated with any of the included factors., (© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)
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- 2024
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78. Nursing leaders' perceptions of the impact of the Strengths-Based Nursing and Healthcare Leadership program three months post training.
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Lavoie-Tremblay M, Boies K, Clausen C, Frechette J, Manning K, Gelsomini C, Cyr G, Lavigne G, Gottlieb B, and Gottlieb LN
- Abstract
Background: Development of nursing leadership is necessary to ensure that nurse leaders of the future are well-equipped to tackle the challenges of a burdened healthcare system. In this context, the Strengths-Based Nursing and Healthcare Leadership program was delivered to 121 participants from 5 organizations in Canada in 2021 and 2022. To date, no study used a qualitative approach to explore nursing leaders' perceptions of a leadership Strengths-Based Nursing and Healthcare Leadership program three months post training., Objective: To describe nursing leaders' perceptions of the impact of the Strengths-Based Nursing and Healthcare Leadership program three months post training., Methods: Qualitative descriptive design was used with individual semi-structured interviews. A convenient sample of nurse leaders ( n = 20) who had participated in the leadership program were recruited for an individual interview three months post training. The data generated by interviews were analyzed using a method of thematic content analysis., Results: Three themes emerged from the qualitative data analysis related to the leadership program that stayed with participants three months post training: 1) mentorship: a lasting relationship , 2) human connections through Story-sharing , and 3) focus on strengths . Two other themes emerged related to the changes that they have made since attending the program: 1) seeking out different perspectives to work better as a team and 2) create a positive work environment and to show appreciation for their staff., Conclusion: The present study offers evidence of the impact of the Strengths-Based Nursing and Healthcare Leadership program three months post training., Implication: This study reinforces the importance of training using a Strengths-Based Nursing and Healthcare Leadership lens when tackling leadership., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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79. Decrypting the putative interrelation between sleep bruxism, masticatory muscle pain and sleep breathing disorders: Nosology and the role of hypoxia.
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Więckiewicz M, Lavigne G, and Martynowicz H
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- Humans, Masticatory Muscles physiology, Sleep physiology, Pain, Hypoxia complications, Sleep Bruxism complications
- Abstract
This commentary on sleep medicine explores whether the potential relationship between sleep bruxism (SB), masticatory muscle pain (MMP) and sleep breathing disorders (SBDs)contributes to improving the management of co-occurring conditions.The paper is divided into 2 sections: (1) reviewing the debate on SB nosology; and (2) based on the publications from the Martynowicz & Wieckiewicz research group, exploringthe role of intermittent hypoxia as a putative mechanism endotype that may link such co-occurrence among individuals for whom characteristics are not yet clear.
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- 2024
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80. Clinical Phenotypes Supporting the Relationship Between Sleep Disturbance and Impairment of Placebo Effects.
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Wang Y, Varghese J, Muhammed S, Lavigne G, Finan P, and Colloca L
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- Humans, Cross-Sectional Studies, Placebo Effect, Sleep, Sleep Initiation and Maintenance Disorders, Chronic Pain
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Lack of good sleep or insomnia can lead to many health issues, including an elevated risk of cardiovascular disease, obesity, fatigue, low mood, and pain. While chronic pain negatively impacts sleep quality, the relationship between descending pain modulatory systems like placebo effects and sleep quality is not thoroughly known. We addressed this aspect in a cross-sectional study in participants with chronic pain. Placebo effects were elicited in a laboratory setting using thermal heat stimulations delivered with visual cues using classical conditioning and verbal suggestions. We estimated the levels of insomnia severity with the Insomnia Severity Index and the sleep quality with the Pittsburg Sleep Quality Index. The previous night's sleep continuity was assessed as total sleep time, sleep efficiency, and sleep midpoint the night before the experiment. 277 people with chronic pain and 189 pain-free control individuals participated. Participants with chronic pain and insomnia showed smaller placebo effects than those with chronic pain without insomnia. Similarly, poor sleep quality was associated with reduced placebo effects among participants with chronic pain. Clinical anxiety measured by Depression Anxiety Stress Scales partially mediated these effects. In contrast, placebo effects were not influenced by the presence of insomnia or poor sleep quality in pain-free participants. Sleep continuity the night before the experiment did not influence the placebo effects. Our results indicate that participants who experience insomnia and/or poor sleep quality and chronic pain have smaller placebo effects, and that the previous night sleep continuity does not influence the magnitude of placebo effects. PERSPECTIVE: This study examined the relationship between sleep disturbances and experimentally induced placebo effects. We found that individuals with chronic pain who experience insomnia and poor sleep quality demonstrated reduced placebo effects compared to their counterparts with good sleep quality and no insomnia., (Copyright © 2024 United States Association for the Study of Pain, Inc. Published by Elsevier Inc. All rights reserved.)
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- 2024
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81. Evaluation of the effectiveness of a Strengths-Based Nursing and Healthcare Leadership program aimed at building leadership capacity: A concurrent mixed-methods study.
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Lavoie-Tremblay M, Boies K, Clausen C, Frechette J, Manning K, Gelsomini C, Cyr G, Lavigne G, Gottlieb B, and Gottlieb LN
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Background: Targeted interventions have been found effective for developing leadership practices in nurses. However, to date, no leadership training program based on the Strengths-Based Nursing and Healthcare Leadership approach exists., Objectives: Demonstrate the effectiveness of a Strengths-Based Nursing and Healthcare Leadership 6-month program designed for nurse and healthcare leaders on leadership capacity and psychological outcomes., Design: Concurrent mixed-methods with nurse and healthcare leaders from five healthcare organisations in Quebec and Ontario (Canada)., Settings: Participants were recruited from five Canadian health care organizations: two in Toronto (Ontario) and three in Montreal (Quebec)., Participants: A total of 50 nurse leaders and healthcare leaders were included in the quantitative component, and 22 (20 nurse leaders and two healthcare leaders) participated in the qualitative individual interviews., Methods: Quantitative and qualitative (interviews) methods were used. Quantitative data (pre-post surveys) were collected from the participants before their participation in the program (Time 0), as well as after the completion of the program (Time 1). Qualitative data (individual interviews) were collected from participants at the end of the program (Time 1). Analysis was conducted using descriptive statistics, paired-sample t -tests, and thematic analysis., Results: Quantitative results suggest a significant improvement in terms of leadership capabilities, work satisfaction, and reduction in perceived stress among participants. Three themes emerged from the qualitative data analysis: 1) focus on people's strengths, 2) structure and language based on Strengths-Based Nursing and Healthcare values, and 3) building support networks., Conclusions: The Strengths-Based Nursing and Healthcare Leadership program developed to build the leadership capabilities of nurse and healthcare leaders was found to be effective. The positive impact of the 6-month program was demonstrated. It was also shown that the leadership program can help improve the leadership competencies, well-being, and work satisfaction of participating nurses and healthcare leaders., Implication: This study reinforces the importance of working with educational, research, and healthcare organizations to establish leadership development programs and mentorship opportunities. Future leadership training should use a Strengths-Based Nursing and Healthcare Leadership lens when tackling leadership and stress in the workplace., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier Ltd.)
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- 2024
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82. Sleep architecture as a candidate for phenotyping sleep bruxism: A narrative physiological review.
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Zhu Y, Toyota R, Shiraishi Y, Katagiri A, Yamada M, Higashiyama M, Toyoda H, Lavigne G, and Kato T
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- Humans, Polysomnography, Arousal physiology, Sleep, Sleep Stages physiology, Sleep Bruxism diagnosis
- Abstract
Background: Sleep bruxism (SB), an oral behaviour in otherwise healthy individuals, is characterised by frequent rhythmic masticatory muscle activity (RMMA) during sleep. RMMA/SB episodes occur over various sleep stages (N1-N3 and rapid eye movement (REM)), sleep cycles (non-REM to REM), and frequently with microarousals. It currently remains unclear whether these characteristics of sleep architecture are phenotype candidates for the genesis of RMMA/SB., Objectives: This narrative review investigated the relationship between sleep architecture and the occurrence of RMMA as a SB phenotype candidate., Methods: PubMed research was performed using keywords related to RMMA/SB and sleep architecture., Results: In non-SB and SB healthy individuals, RMMA episodes were most frequent in the light non-REM sleep stages N1 and N2, particularly during the ascending phase of sleep cycles. The onset of RMMA/SB episodes in healthy individuals was preceded by a physiological arousal sequence of autonomic cardiovascular to cortical activation. It was not possible to extract a consistent sleep architecture pattern in the presence of sleep comorbidities. The lack of standardisation and variability between subject complexified the search for specific sleep architecture phenotype(s)., Conclusion: In otherwise healthy individuals, the genesis of RMMA/SB episodes is largely affected by oscillations in the sleep stage and cycle as well as the occurrence of microarousal. Furthermore, a specific sleep architecture pattern cannot be confirmed in the presence of sleep comorbidity. Further studies are needed to delineate sleep architecture phenotype candidate(s) that contribute to the more accurate diagnosis of SB and treatment approaches using standardised and innovative methodologies., (© 2023 John Wiley & Sons Ltd.)
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- 2024
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83. Validation of the Nursing Student Peripheral Intravenous Catheter Insertion Self-Confidence Scale.
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Marchionni C, Lavigne G, and Connolly M
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Background and Purpose: It has been shown that nurse confidence predicts peripheral intravenous catheter (PIVC) insertion success. However, intravenous cannulation is a challenging skill for entry to practice students. To date, there is no well-validated measure of nursing student self-confidence in learning and performing PIVC insertion. To address this measurement gap, we created and validated the Nursing Student PIVC Insertion Self-Confidence Scale. Methods: This study employed a descriptive, cross-sectional design. Three cohorts of undergraduate entry-to-practice students at a Canadian university were recruited and assessed during their studies. Two hundred and eighty-one students completed the scale at the first data collection point and 146 at the second point. The structure of the tool was analyzed by exploratory factor analysis to extract factors and confirmatory factor analysis (CFA) was employed for validation. Results: CFA revealed a three-factor scale (PIVC Cannulation Confidence, PIVC Preparation and Securement Confidence, and PIVC Learning Confidence). It has 15 items with satisfactory goodness of fit indices. Conclusions: The Nursing Student PIVC Insertion Self-Confidence Scale is a valid and reliable scale to measure nursing students' confidence in learning about and performing PIVC insertions., (© 2023 Springer Publishing Company, LLC.)
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- 2023
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84. An exploratory study on the association between serotonin and sleep breathing disorders.
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Wieckiewicz M, Martynowicz H, Lavigne G, Lobbezoo F, Kato T, Winocur E, Wezgowiec J, Danel D, Wojakowska A, Mazur G, and Smardz J
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- Humans, Serotonin, Respiration, Sleep, Sleep Apnea Syndromes, Sleep Apnea, Obstructive, Airway Obstruction, Sleep Wake Disorders
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This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio-video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea-hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels.Clinical Trial Registration : www.ClinicalTrials.gov , identifier NCT04214561., (© 2023. The Author(s).)
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- 2023
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85. The effects of mandibular advancement appliance therapy on jaw-closing muscle activity time-related to oxygen desaturations: A randomised controlled trial.
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Kuang B, Aarab G, Lobbezoo F, Tran BT, Arcache P, Lavigne G, and Huynh N
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- Humans, Adult, Middle Aged, Polysomnography, Hypoxia, Muscles, Oxygen, Mandibular Advancement, Sleep Apnea, Obstructive therapy
- Abstract
Background: Previous study showed that in individuals with obstructive sleep apnea (OSA), the contractions of masseter muscles after respiratory events can be nonspecific motor phenomena, dependent on the duration of respiratory arousals rather than the occurrence of the respiratory events. However, the role of intermittent hypoxia in the occurrence of jaw-closing muscle activities (JCMAs) was not taken into consideration. An exposure to intermittent hypoxia has been shown to initiate a series of activities, including muscular sympathetic activity in patients with OSA., Objective: To determine the effects of mandibular advancement appliance (MAA) therapy on JCMA time-related to oxygen desaturation with and without arousal in individuals with OSA., Methods: Eighteen individuals with OSA (age: 49.4 ± 9.8 years, apnea-hypopnea index (AHI): 10.0|18.4|30.3, JCMA index: 1.7|4.3|5.6), participated in a randomised controlled crossover clinical trial, in which two ambulatory polysomnographic recordings were performed: one with MAA in situ and the other without MAA in situ. JCMAs were recorded bilaterally from both masseter and temporalis muscles., Results: There was no significant effect of the MAA on the overall JCMA index (Z = -1.372, p = .170). With the MAA in situ, JCMA index time-related to oxygen desaturation with arousal significantly decreased (Z = -2.657, p = .008), while there was no significant effect of the MAA on the JCMA index time-related to oxygen desaturation without arousal (Z = -0.680, p = .496)., Conclusion: Effective mandibular advancement appliance therapy significantly reduces jaw-closing muscle activities time-related to oxygen desaturation with arousal in individuals with OSA., (© 2023 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.)
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- 2023
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86. Examining the associations between mothers' motivation to regulate their own eating behaviors, food parenting practices and perceptions of their child's food responsiveness.
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Carbonneau N, Carbonneau É, Dumas AA, Lavigne G, and Guimond FA
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- Female, Child, Humans, Child, Preschool, Body Weight, Body Mass Index, Motivation, Mother-Child Relations, Canada, Feeding Behavior psychology, Child Behavior psychology, Surveys and Questionnaires, Mothers psychology, Parenting psychology
- Abstract
Based on the Self-Determination Theory, this study examined: 1) how mothers' autonomous and controlled motivation to regulate their own eating behaviors relate to their food parenting practices, and 2) whether and how child food responsiveness (i.e., reactivity and attraction to food) interact with mothers' motivation to predict maternal food parenting practices. Participants were 296 French Canadian mothers of at least one child aged between 2 and 8 years old. Results of partial correlation analyses (controlling for demographics and controlled motivation) showed that maternal autonomous motivation to regulate their own eating behaviors was positively related to autonomy-promoting (i.e., child involvement) and structure-based (i.e., modeling, creating a healthy environment, monitoring) food parenting practices. In contrast, controlling for demographics and autonomous motivation, maternal controlled motivation was positively associated with food-related practices based on coercive control (i.e., the use of food to regulate the child's emotions, the use of food as a reward, pressure to eat, restriction for weight reasons, and restriction for health reasons). Furthermore, the child's food responsiveness was found to interact with mothers' motivation to regulate their own eating behaviors in the prediction of maternal food parenting practices such that mothers with high autonomous motivation or low controlled motivation were found to react with more structure-based (i.e., creating a healthy environment) and autonomy-based (i.e., child involvement) practices, as well as less controlling practices (i.e., the use of food to regulate the child's emotions), to a child who is highly responsive to food. In conclusion, findings suggest that guiding mothers toward developing a more autonomous and less controlled motivation to regulate their own eating behaviors might help them adopt more autonomy-promoting and structure-based and less controlling feeding practices, especially with children who are highly responsive to food., Competing Interests: Declaration of competing interest All authors have no interest to declare., (Copyright © 2023 Elsevier Ltd. All rights reserved.)
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- 2023
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87. Airway Phenotypes and Nocturnal Wearing of Dentures in Elders with Sleep Apnea.
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Chen H, Emami E, Kauffmann C, Rompré P, Almeida F, Schmittbuhl M, van der Stelt P, Ge S, Lavigne G, and Huynh N
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- Male, Female, Humans, Respiratory System, Sleep, Oxygen, Dentures, Sleep Apnea, Obstructive, Mouth, Edentulous complications
- Abstract
The objective of this study was to examine to what extent the anatomic characteristics of the upper airway can influence the effect of nocturnal wearing of dentures on the sleep of edentulous elders with untreated sleep apnea. This study used the data from a randomized crossover clinical trial and an exploratory approach to address its objectives. Cone beam computed tomography scans of 65 edentulous individuals (female, n = 37; male, n = 28; mean ± SD age, 74.54 ± 6.42 y) with untreated obstructive sleep apnea (OSA) were used to identify anatomic variables. Polysomnography data were collected by means of one portable overnight recording. The respiratory variable values, including apnea-hypopnea index (AHI), with and without denture worn during sleep were used to calculate the change. Statistical analyses included multiple linear regressions, cluster analysis, and binary logistic regressions. A receiver operator characteristic curve was used to illustrate the accuracy of the statistical model. The regression model explained 15.8% ( R
2 ) of AHI change. An increase in the lateral dimension of the minimum cross-sectional area was associated with a decrease in AHI, oxygen desaturation index, and respiratory arousal index changes ( P ≤ 0.041). Furthermore, an increase in the length of the hypopharynx was associated with an increase in AHI and oxygen desaturation index changes ( P ≤ 0.027). An increase in the lateral dimension of the minimum cross-sectional area of the upper airway was associated with a decreased likelihood of being in the group having a worsened AHI (odds ratio = 0.85; 95% CI, 0.76 to 0.95; P = 0.006). An increase in the length of the oropharynx was associated with an increased likelihood of having increased AHI (odds ratio = 1.10; 95% CI, 1.01 to 1.20; P = 0.026). The nocturnal aggravation of respiratory variables in edentulous individuals with OSA who wear dentures at night can be linked to certain anatomic characteristics of the upper airway. Replication of these findings may open novel avenues for personalized advice regarding nocturnal wearing of dentures in edentulous individuals with OSA (ClinicalTrials.gov: NCT01868295).- Published
- 2023
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88. Association between night pain and quality of life in women: A general population sleep study.
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Lucena L, Lavigne G, Fabbro CD, Andersen ML, Tufik S, and Hachul H
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- Humans, Female, Polysomnography adverse effects, Depression psychology, Pain epidemiology, Pain complications, Fatigue etiology, Sleep, Quality of Life, Sleep Wake Disorders epidemiology
- Abstract
Background: Women with pain present decreased sleep duration and quality of life, but little is known about the consequences of nighttime pain on overall health. Our goal was to compare levels of anxiety, depression and fatigue in women with pain during the night with those without pain. We hypothesized that pain perception is associated with the worsening of fatigue and mood., Methods: In total, 244 women aged 20-80 years who took part in the Epidemiologic Sleep Study (EPISONO) met the inclusion criteria, 85 in the self-reported pain group and 171 in the control group. Participants were assigned to the pain group if they both responded (i) they generally had pain, according to Pre-Sleep Questionnaire (PSQ) and (ii) their pain generally interfered with their sleep 3 or more times a week, according to Pittsburg Sleep Quality Index (PSQI). Those who answered negatively to both questions were allocated to the control group. All participants underwent a full night laboratory polysomnography, and completed questionnaires related to fatigue, depression, anxiety and quality of life., Results: Pain group participants had a significantly lower perception of quality of life, and significantly higher levels of fatigue (5.4 times), anxiety and depression. Pain perception was also correlated to levels of anxiety and depression in the psychological (r
s = -0.463, -0.607, respectively) and social (rs = -0.423, -0.438, respectively) quality of life domains., Conclusions: Nighttime pain in women was associated with decreased quality of life, worsening mood and fatigue. Our data shows the importance of investigating pain and its deleterious effects on women's health., Significance: Our study highlights that women experiencing nighttime pain also reported worse mood outcomes and decreased quality of life, regardless of the level and type of pain. Our data, based on association analysis and not investigating causality, suggest it is important to consider nighttime pain in clinical care to improve quality of life and general health., (© 2022 European Pain Federation - EFIC ®.)- Published
- 2023
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89. Sleep bruxism and obstructive sleep apnea: association, causality or spurious finding? A scoping review.
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Pauletto P, Polmann H, Conti Réus J, Massignan C, de Souza BDM, Gozal D, Lavigne G, Flores-Mir C, and De Luca Canto G
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- Comorbidity, Humans, Prevalence, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive diagnosis, Sleep Apnea, Obstructive epidemiology, Sleep Bruxism complications, Sleep Bruxism diagnosis, Sleep Bruxism epidemiology
- Abstract
Study Objectives: To evaluate the available evidence on the putative relationships between sleep bruxism (SB) and, obstructive sleep apnea (OSA) to assess the extent of research on this topic, and to formulate suggestions for future research., Methods: A scoping review including studies examining temporal and overall association and prevalence of SB and OSA was performed. Six main databases and gray literature were searched. The studies selection was conducted by three independent reviewers. A narrative synthesis of the results was carried out., Results: Thirteen studies in adults and eight studies in children were finally included. The median of concomitant conditions prevalence was 39.3% in adults and 26.1% in children. Marked methodological variability was identified among studies in adults and even more when we compared detection methods in children. No significant association between OSA and SB emerged in most studies in adults, while an association may be possible in children., Conclusions: Based on the current literature, it is not possible to confirm that there is a relationship between SB and OSA in adults. In patients under pediatric care, although this association seems plausible, there is currently insufficient supportive evidence. Standardized validated methodologies for identifying SB should be consistently used in both populations before reaching any conclusion regarding such association. Furthermore, assessment of shared phenotypes between patients with SB and patients with OSA may reveal new insights that will contribute to personalized approaches aiming to optimize the management of such comorbidities., (© The Author(s) 2022. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2022
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90. Nurses' perception of integrating an innovative clinical hypnosis-derived intervention into outpatient chemotherapy treatments.
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Hjeij D, Bilodeau K, Ogez D, Tremblay M, Lavigne G, Rainville P, and Arbour C
- Abstract
Introduction: Conversational hypnosis (CH) is known to optimize the management of symptoms resulting from antineoplastic treatment. However, the perception of nurses who have been called upon to integrate this practice into their care has yet to be documented., Goal: Describe how nurses perceive the integration of CH into chemotherapy-related care., Methods: Individual interviews and an iterative analysis were conducted with six nurses who had previous experience in CH in an outpatient oncology clinic., Findings: Six themes emerged: 1) the outpatient oncology clinic, a saturated care setting; 2) the key elements supporting the integration of CH into care; 3) an added value for patients; 4) a positive and rewarding experience for nurses; 5) collateral benefits; and 6) CH, an approach that warrants consideration amid the pandemic., Conclusion: These findings shed light on nurses' unique point of view regarding the challenges and benefits of integrating CH into oncology care., Competing Interests: CONFLICTS OF INTEREST The authors declare no conflict of interest., (© 2022 Canadian Association of Nurses in Oncology (CANO).)
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- 2022
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91. La perception des infirmières quant à l’intégration d’une intervention novatrice inspirée de l’hypnose clinique aux traitements de chimiothérapie à la clinique externe d’oncologie.
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Hjeij D, Bilodeau K, Ogez D, Tremblay M, Lavigne G, Rainville P, and Arbour C
- Abstract
Competing Interests: DÉCLARATION DE CONFLIT D’INTÉRÊTS Les auteurs déclarent n’avoir aucun conflit d’intérêts.
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- 2022
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92. Lessons from Long-Term Care Facilities without COVID-19 Outbreaks.
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Lavoie-Tremblay M, Cyr G, Aubé T, and Lavigne G
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- Disease Outbreaks prevention & control, Humans, Long-Term Care, Nursing Homes, Pandemics, COVID-19 epidemiology
- Abstract
Background: The COVID-19 crisis in long-term care (LTC) homes was devastating for residents and front-line workers. Recent reports have detailed what went wrong in LTC facilities, including equipment shortages, lack of preparedness, underestimation of COVID-19's virulence and bans on caregiver visits. Less is known about what went well in some facilities., Purpose: To describe nurses' and other staff members' experiences and lessons learned in two LTC facilities in Quebec that reported no COVID-19 outbreaks during the first wave of the pandemic., Methods: Methods: A case study design guided by appreciative inquiry was conducted, in which a case was defined as a LTC facility without COVID-19 outbreaks; two cases were included. Twenty-three healthcare team members from the two sites were recruited and interviewed between October and November, 2020., Results: Several common themes were identified: being informed and respecting outbreak protocols; the presence of key outbreak protocols, which allowed for stable teams; a clear action plan; and access to materials and resources. Key management themes included team support and reward, ongoing communication and providing compassionate care to residents., Conclusion: This study highlights several lessons learned that have the potential to strengthen the LTC health system., (Copyright © 2022 Longwoods Publishing.)
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- 2022
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93. Metasurface magnetless specular isolator.
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Lavigne G, Kodera T, and Caloz C
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We present a (nongyrotropic) metasurface magnetless specular isolator. This device reflects as a mirror a wave incident under a specified angle in one direction and absorbs it in the opposite direction. The metasurface is synthesized in terms of bianisotropic susceptibility tensors, whose nonreciprocity resides in normal components and exhibits a hybrid electric, magneto-electric nature. The metaparticle is implemented in the form of a U-shaped conducting structure loaded by a transistor. The operation principle of the specular isolator is demonstrated by both full-wave simulation and experiment, with isolation levels reaching 41 and 38 dB respectively. This system represents the first realization of a metasurface involving nonreciprocal normal susceptibilities and features a previously unreported type of nonreciprocity., (© 2022. The Author(s).)
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- 2022
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94. Orofacial Pain and Snoring/Obstructive Sleep Apnea in Individuals with Head and Neck Cancer: A Critical Review.
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Dal Fabbro C, Harris P, Dufresne E, Herrero Babiloni A, Mayer P, Bahig H, Filion E, Nguyen F, Ghannoum J, Schmittbuhl M, and Lavigne G
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- Facial Pain epidemiology, Facial Pain etiology, Humans, Prevalence, Snoring epidemiology, Snoring therapy, Head and Neck Neoplasms complications, Sleep Apnea, Obstructive epidemiology, Sleep Apnea, Obstructive therapy
- Abstract
Aims: (1) To summarize current knowledge on the prevalence, intensity, and descriptors of orofacial pain and snoring/obstructive sleep apnea (OSA) before and after head and neck cancer (HNC) treatment; and (2) to propose future directions for research., Methods: The median prevalence for each condition was estimated from the most recent systematic reviews (SRs) and updated with new findings retrieved from the PubMed, Web of Science, Embase, and Cochrane databases up to December 2021., Results: The prevalence of HNC pain seems relatively stable over time, with a median of 31% before treatment in three studies to a median of 39% at 1 month to 16 years after treatment in six studies. HNC pain intensity remains mild to moderate. There was a threefold increase in temporomandibular pain prevalence after surgery (median 7.25% before to 21.3% after). The data for snoring prevalence are unreliable. The OSA/HNC prevalence seems relatively stable over time, with a median of 72% before treatment in three studies to 77% after treatment in 14 studies., Conclusion: With the exception of temporomandibular pain, the prevalence of HNC pain and OSA seems to be stable over time. Future studies should: (1) compare the trajectory of change over time according to each treatment; (2) compare individuals with HNC to healthy subjects; (3) use a standardized and comparable method of data collection; and (4) assess tolerance to oral or breathing devices, since HNC individuals may have mucosal sensitivity or pain.
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- 2022
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95. Comparison of anatomic and aerodynamic characteristics of the upper airway among edentulous mild, moderate, and severe obstructive sleep apnea in older adults.
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Chen H, Elham E, Li Y, Ge S, Schmittbuhl M, Lavigne G, van der Stelt PF, and Huynh N
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- Aged, Cone-Beam Computed Tomography methods, Humans, Polysomnography, Quality of Life, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive diagnostic imaging
- Abstract
Study Objectives: First, to compare the upper airway's anatomic and aerodynamic characteristics of the edentulous older adults who experience mild, moderate, and severe obstructive sleep apnea (OSA). Second, to examine the correlation between the severity of OSA and the anatomic and aerodynamic characteristic(s) of the upper airway in these edentulous individuals., Methods: NewTom5G cone beam computed tomography scans of 58 edentulous individuals with mild, moderate, and severe OSA were included in this analysis. 1) Computational models of the upper airway were reconstructed based on cone beam computed tomography images and the anatomical and aerodynamic characteristics of the upper airway were examined by an observer blind to OSA severity. 2) Pearson correlation analysis was used to determine the correlation between apnea-hypopnea index and the anatomic and aerodynamic characteristics of the upper airway., Results: Compared with edentulous patients with mild and moderate OSA, those with severe OSA have a more hourglass-shaped upper airway. The severity of OSA, namely, apnea-hypopnea index, was significantly correlated with the length, shape, and minimum cross-sectional area of the upper airway. During inspiration, the mean velocity of the airflow within the upper airway of the edentulous patients with severe OSA was higher than that of patients with mild and moderate OSA. During both inspiration and expiration, apnea-hypopnea index was found to be significantly correlated with maximum velocity ( P = .05) and airway resistance ( P = .024, 0.038)., Conclusions: The edentulous patients with severe OSA have a more hourglass-shaped upper airway. The findings also suggest that, during inspiration, the airflow travels faster in edentulous patients with severe OSA than in those with mild or moderate OSA., Clinical Trial Registration: Registry: ClinicalTrials.gov; Name: The Effect of Nocturnal Wear of Dentures on Sleep and Oral Health Related Quality of Life; URL: https://clinicaltrials.gov/ct2/show/NCT01868295; Identifier: NCT01868295., Citation: Chen H, Elham E, Li Y, et al. Comparison of anatomic and aerodynamic characteristics of the upper airway among edentulous mild, moderate, and severe obstructive sleep apnea in older adults. J Clin Sleep Med . 2022;18(3):759-768., (© 2022 American Academy of Sleep Medicine.)
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- 2022
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96. Association between fentanyl treatment for acute pain in the emergency department and opioid use two weeks after discharge.
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Daoust R, Paquet J, Huard V, Chauny JM, Lavigne G, Williamson D, Choinière M, Lang E, Yan JW, Perry JJ, Emond M, Gosselin S, and Cournoyer A
- Subjects
- Adult, Aged, Case-Control Studies, Emergency Service, Hospital statistics & numerical data, Female, Humans, Male, Middle Aged, Opioid-Related Disorders epidemiology, Practice Patterns, Physicians' statistics & numerical data, Prospective Studies, Acute Pain drug therapy, Analgesics, Opioid administration & dosage, Fentanyl administration & dosage
- Abstract
Background: Analgesia with fentanyl can be associated with hyperalgesia (higher sensitivity to pain) and can contribute to escalating opioid use. Our objective was to assess the relationship between emergency department (ED) acute pain management with fentanyl compared to other opioids, and the quantity of opioids consumed two-week after discharge. We hypothesized that the quantity of opioids consumed would be higher for patients treated with fentanyl compared to those treated with other opioids., Methods: Patients were selected from two prospective cohorts assessing opioids consumed after ED discharge. Patients ≥18 years treated with an opioid in the ED for an acute pain condition (≤2 weeks) and discharged with an opioid prescription were included. Patients completed a 14-day paper or electronic diary of pain medication use. Quantity of 5 mg morphine equivalent tablets consumed during a 14-day follow-up by patients treated with fentanyl compared to those treated with other opioids during their ED stay were analyzed using a multiple linear regression and propensity scores., Results: We included 707 patients (mean age ± SD: 50 ± 15 years, 47% women) in this study. During follow-up, patients treated with fentanyl (N = 91) during their ED stay consumed a median (IQR) of 5.8 (14) 5 mg morphine equivalent pills compared to 7.0 (14) for those treated with other opioids (p = 0.05). Results were similar using propensity score sensitivity analysis. However, after adjusting for confounding variables, ED fentanyl treatment showed a trend, but not a statistically significant association with a decreased opioid consumption during the 14-day follow-up (B = -2.4; 95%CI = -5.3 to 0.4; p = 0.09)., Conclusions: Patients treated with fentanyl during ED stay did not consume more opioids after ED discharge, compared to those treated with other opioids. If fentanyl does cause more hyperalgesia compared to other opioids, it does not seem to have a significant impact on opioid consumption after ED discharge., Competing Interests: Declaration of Competing Interest There is no financial benefit or conflict of interest to report from all co-authors., (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2022
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97. Associations between sleep bruxism and other sleep-related disorders in adults: a systematic review.
- Author
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Kuang B, Li D, Lobbezoo F, de Vries R, Hilgevoord A, de Vries N, Huynh N, Lavigne G, and Aarab G
- Subjects
- Adult, Humans, Sleep, Restless Legs Syndrome complications, Restless Legs Syndrome epidemiology, Sleep Apnea, Obstructive complications, Sleep Bruxism complications, Sleep Wake Disorders complications, Sleep Wake Disorders epidemiology
- Abstract
Objective: Systematic reviews on sleep bruxism (SB) as a comorbid condition of other sleep-related disorders are lacking. Such reviews would contribute to the insight of sleep clinicians into the occurrence of SB in patients with other sleep-related disorders, and into the underlying mechanisms of such comorbid associations. This systematic review aimed: 1. to determine the prevalence of SB in adults with other sleep-related disorders; and 2. to determine the associations between SB and other sleep-related disorders, and to explain the underlying mechanisms of these associations., Methods: A systematic search on SB and sleep-related disorders was performed in PubMed, Embase, Cochrane Library, and Web of Science to identify eligible studies published until May 15, 2020. Quality assessment was performed using the Risk of Bias Assessment tool for Non-randomized Studies., Results: Of the 1539 unique retrieved studies, 37 articles were included in this systematic review. The prevalence of SB in adult patients with obstructive sleep apnea, restless leg syndrome, periodic limb movement during sleep, sleep-related gastroesophageal reflux disease, REM behavior disorder (RBD), and sleep-related epilepsy was higher than that in the general population. The specific mechanisms behind these positive associations could not be identified., Conclusions: SB is more prevalent in patients with the previously mentioned disorders than in the general population. Sleep arousal may be a common factor with which all the identified disorders are associated, except RBD and Parkinson's disease. The associations between SB and these identified sleep-related disorders call for more SB screening in patients with the abovementioned sleep-related disorders., (Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.)
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- 2022
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98. Feasibility and acceptability of hypnosis-derived communication administered by trained nurses to improve patient well-being during outpatient chemotherapy: a pilot-controlled trial.
- Author
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Arbour C, Tremblay M, Ogez D, Martineau-Lessard C, Lavigne G, and Rainville P
- Subjects
- Communication, Feasibility Studies, Humans, Palliative Care, Hypnosis, Outpatients
- Abstract
Purpose: This pilot-controlled trial aimed to examine the feasibility and acceptability of hypnosis-derived communication (HC) administered by trained nurses during outpatient chemotherapy to optimize symptom management and emotional support - two important aspects of patient well-being in oncology., Methods: The trial was conducted in two outpatient oncology units: (1) intervention site (usual care with HC), and (2) control site (usual care). Nurses at the intervention site were invited to take part in an 8-h training in HC. Participants' self-ratings of symptoms and emotional support were gathered at predetermined time points during three consecutive outpatient visits using the Edmonton Symptom Assessment Scale and the Emotional Support Scale., Results: Forty-nine patients (24 in the intervention group, 25 in the control group) with different cancer types/stages were recruited over a period of 3 weeks and completed the study. All nurses (N = 10) at the intervention site volunteered to complete the training and were able to include HC into their chemotherapy protocols (about ± 5 min/intervention). Compared to usual care, patients exposed to HC showed a significant reduction in physical symptoms during chemotherapy. In contrast, perception of emotional support did not show any significant effect of the intervention. Participants exposed to HC report that the intervention helped them relax and connect on a more personal level with the nurse during chemotherapy infusion., Conclusions: Our results suggest that HC is feasible, acceptable, and beneficial for symptom management during outpatient chemotherapy. While future studies are needed, hypnosis techniques could facilitate meaningful contacts between cancer patients and clinicians in oncology., Trial Registration: Clinical Trial Identifier: NCT04173195, first posted on November 19, 2019., (© 2021. Crown.)
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- 2022
- Full Text
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99. Optimizing nurses' enacted scope of practice to its full potential as an integrated strategy for the continuous improvement of clinical performance: A multicentre descriptive analysis.
- Author
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Déry J, Paquet M, Boyer L, Dubois S, Lavigne G, and Lavoie-Tremblay M
- Subjects
- Canada, Humans, Job Satisfaction, Scope of Practice, Surveys and Questionnaires, Nurses, Nursing Staff, Hospital
- Abstract
Aim: This study aims at better understanding the relationships between nurses' enacted scope of practice, work environment and work satisfaction, missed care, and organizational indicators of performance., Background: The enacted scope of practice model describes the determinants and consequences of the actual enactment of the nursing scope of practice., Method: A correlational design was used to investigate nurses' enacted scope of practice in five Canadian healthcare centres., Results: Suboptimal enacted scope of practice were found in the current sample. Significant positive correlations were found between the total enacted scope of practice score, use of qualification, control over tasks, decisional latitude and psychological demand as well as role ambiguity. Moreover, a higher enacted scope of practice was correlated with lower organizational indicators of short-term absenteeism., Conclusion: Results suggest an insufficient deployment of nurses' enacted scope of practice, likely caused by some job characteristics, leading to lower work satisfaction and negative patients and organizational outcomes., Implications for Nursing Management: Optimizing nurses' enacted scope of practice would be a significant integrated strategy for improving organizational performance, patient care and nurses' satisfaction and well-being. Nurses and frontline managers must be involved in the decision-making process necessary to improve nurses' enacted scope of practice., (© 2021 John Wiley & Sons Ltd.)
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- 2022
- Full Text
- View/download PDF
100. Feel Good, Eat Better: The Role of Self-Compassion and Body Esteem in Mothers' Healthy Eating Behaviours.
- Author
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Carbonneau N, Holding A, Lavigne G, and Robitaille J
- Subjects
- Adult, Emotions, Feeding Behavior, Female, Humans, Body Image, Diet, Healthy, Mothers, Self Concept, Self-Compassion
- Abstract
Mothers' eating behaviours are important to ensure the health and well-being of themselves and their families. Recent research has pointed to self-compassion, defined as extending kindness to oneself in times of perceived inadequacy or general suffering, as a trait associated with healthy forms of eating, such as intuitive eating, and reduced maladaptive forms of eating, such as emotional eating. However, little is known about the psychological mechanism through which self-compassion relates to healthy eating behaviours. This study examined 100 mothers' levels of self-compassion, body esteem and eating behaviours. Structural equation modelling revealed that self-compassion was positively associated with diet quality and intuitive eating, while being negatively associated with emotional eating. Moreover, these links occurred, in part, due to higher body esteem. This points to a mechanism through which self-compassion may positively contribute to mothers' healthy eating behaviours. The implications for eating outcomes and women's health are discussed.
- Published
- 2021
- Full Text
- View/download PDF
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