230 results on '"G. Chéron"'
Search Results
52. [Boxing-related cranial injury in children: a case report]
- Author
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S, Timsit, T, Rougeau, D, Grevent, and G, Chéron
- Subjects
Male ,Hematoma, Subdural ,Imaging, Three-Dimensional ,Adolescent ,Head Injuries, Closed ,Athletic Injuries ,Image Interpretation, Computer-Assisted ,Humans ,France ,Boxing ,Tomography, X-Ray Computed ,Magnetic Resonance Imaging ,Thrombocytopenia - Abstract
No pediatric recommendations exist in France on the exercise of boxing by children and adolescents despite the risk of traumatic injury, sometimes serious. We report the case of a 15-year-old boy who participated in amateur boxing and had a subdural hematoma. Brain injuries and concussions are frequent and multiple. Severity is not always correlated with the intensity of the blows. There are age-related features. Several international medical organizations oppose boxing for children and adolescents.
- Published
- 2012
53. Pump requirements for betatron-generated femtosecond X-ray laser at saturation from inner-shell transitions
- Author
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K. Ta Phuoc, Antoine Rousse, P. Ribeiro, Julien Gautier, Ph. Zeitoun, B. G. Chéron, S. Jacquemot, J. Grunenwald, M. Ribière, Stéphane Sebban, Michaela Kozlova, GRAMAT (DAM/GRAMAT), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'optique appliquée (LOA), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), DAM Île-de-France (DAM/DIF), Laboratoire pour l'utilisation des lasers intenses (LULI), Université Pierre et Marie Curie - Paris 6 (UPMC)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Complexe de recherche interprofessionnel en aérothermochimie (CORIA), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Amplified spontaneous emission ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,Materials science ,Active laser medium ,Physics and Astronomy (miscellaneous) ,General Engineering ,General Physics and Astronomy ,Physics::Optics ,Betatron ,Laser ,7. Clean energy ,01 natural sciences ,law.invention ,010309 optics ,X-ray laser ,law ,0103 physical sciences ,Femtosecond ,Laser power scaling ,Atomic physics ,010306 general physics ,Saturation (chemistry) - Abstract
International audience; We study pump requirements to produce femtosecond X-ray laser pulses at saturation from inner-shell transitions in the amplified spontaneous emission regime. Since laser-based betatron radiation is considered as the pumping source, we first study the impact of the driving laser power on its intensity. Then we investigate the amplification behavior of the K-a transition of nitrogen at 3.2 nm (395 eV) from radiative transfer calculations coupled with kinetics modeling of the ion population densities. We show that the saturation regime may be experimentally achieved by using PW-class laser-accelerated electron bunches. Finally, we show that this X-ray laser scheme can be extended to heavier atoms and we calculate pump requirements to reach saturation at 1.5 nm (849 eV) from the K-a transition of neon. © Springer-Verlag 2012.
- Published
- 2012
54. [Clinical features and outcome of 2009 H1N1 influenza in the pediatric setting. Multicenter prospective study in the ED]
- Author
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C, Desmoulins, A-P, Michard-Lenoir, J, Naud, I, Claudet, V, Nouyrigat, and G, Chéron
- Subjects
Male ,Adolescent ,Infant, Newborn ,Infant ,Antiviral Agents ,Hospitalization ,Influenza A Virus, H1N1 Subtype ,Oseltamivir ,Treatment Outcome ,Child, Preschool ,Influenza, Human ,Humans ,Female ,Prospective Studies ,Child ,Emergency Service, Hospital - Abstract
The clinical manifestations and outcome of infants and children with confirmed 2009 H1N1 influenza in emergency departments is described.We conducted a prospective multicenter case series involving children with symptoms of influenza-like illness in whom 2009 H1N1 influenza was diagnosed on reverse-transcriptase polymerase chain reaction assay on a nasopharyngeal swab or nasal aspirates and who were admitted to the ED of four university pediatric hospitals. The following data were collected: age, gender, preexisting chronic conditions (PECs) associated with a high risk for influenza-related complications, clinical symptoms, outcome, antiviral treatment, and complications. We recorded length of cough and fever during a phone-call on day 8.Between 1st October and 31st December 2009, 466 children were included. Their median age was 4 years (range, 1 day to 17 years). The median time to consultation was 24h. Of these 466 infants and children, 55 were aged less than three months and 153 had one or more PECs. Asthma was the most frequent condition. Children at risk and children without risk did not differ for complications (28% vs 31%, P0.05). Respiratory complications (17%) and decompensations of preexisting disease were the most frequent. Infants aged less than three months did not have more complications than infants without PECs. At-risk infants and children were more frequently hospitalized (P0.02) and the duration of the pediatric ward stay was longer (P0.02). This was true only for children aged less than three months. Of the hospitalized children, 17 (9%) were admitted to an ICU. Duration of fever (3.8 days) and duration of cough (6.3 days) did not differ according to whether or not children received oseltamivir.Infants younger than three months of age are not a group at risk for influenza-related complications. Oseltamivir did not reduce duration of symptoms in this population.
- Published
- 2010
55. [Minoxidil intoxication, the pharmacological agent of a hair lotion]
- Author
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A, Aprahamian, S, Escoda, G, Patteau, A, Merckx, and G, Chéron
- Subjects
Treatment Outcome ,Child, Preschool ,Tachycardia ,Vasodilator Agents ,Hair Preparations ,Minoxidil ,Humans ,Female ,Hypotension ,Monitoring, Physiologic - Abstract
Accidental intoxications in children are frequent but most of them are without serious consequences. We describe herein the case of a young girl who drank 100 mg of a topical hair lotion with minoxidil. On arrival, she had no symptoms except flush on the face and ears. Four and half hours after ingestion, tachycardia appeared with a pulse above 170 beats per min with hypotension at 76/24 mmHg. The heart rate remained between 170 and 190 beats per min for 12 h and then lowered to between 140 and 160 beats per min. Thirty-six hours after ingestion, the heart beat was at 140 beats per min. Minoxidil is a strong vasodilator used first in the 1970s for severe hypertension. It produces hypotension by direct arteriolar vasodilatation. Only a few cases of minoxidil intoxication have been described in the literature, including only one pediatric case. This young boy had only tachycardia of 160 beats per min for 40 h. Most serious cases have been described in adults. They suffered long-lasting tachycardia, hypotension, and ECG changes. Most patients need a bolus of normal saline fluid and some with hemodynamic problems need vasoactive drugs such as dopamine and/or phenylephrine. All patients need to be under medical supervision for a long time because of the product's very long action.
- Published
- 2010
56. [Neurological complications revealing infectious endocarditis: 2 case reports]
- Author
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V, Nouyrigat, G, Patteau, F, Bajolle, M-C, Anthoine-Milhommes, H, Chappuy, and G, Chéron
- Subjects
Male ,Adolescent ,Humans ,Female ,Endocarditis, Bacterial ,Nervous System Diseases ,Child - Abstract
Neurological signs are reported in less than 20% of infectious endocarditis (IE) cases. The most frequent complications include cerebral infarction, intracerebral hemorrhage, meningitis, and mycotic aneurysm. We describe two patients, one with congenital heart disease and the other with normal heart, who presented neurological manifestations and fever leading to an IE diagnosis. Neurological complications may be the first symptom of infectious endocarditis and are a major factor associated with increased morbidity and mortality. Early diagnosis and early treatment will minimize cardiac and neurological morbidities.
- Published
- 2010
57. [Medications dosage and adherence]
- Author
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H, Chappuy, G, Patteau, J-M, Tréluyer, and G, Chéron
- Subjects
Humans ,Patient Compliance ,Drug Dosage Calculations ,Child - Published
- 2009
58. [Intensive care course for pediatricians in the emergency department]
- Author
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G, Chéron, S, Escoda, G, Patteau, and B, Cojocaru
- Subjects
Critical Care ,Emergency Service, Hospital ,Pediatrics - Published
- 2009
59. Mort subite, malaise vagal et prantal
- Author
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G. Chéron
- Subjects
Pediatrics, Perinatology and Child Health - Abstract
La mort subite d'un nourrisson apparemment sain est devenue la circonstance la plus frequente de deces entre 1 mois et 1 an dans tous les pays industrialises.
- Published
- 1991
60. [Sedation in the emergency department: how far can and should we go?]
- Author
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G, Chéron, O, Brissaud, C, Wille, and H, Chappuy
- Subjects
Analgesics ,Dose-Response Relationship, Drug ,Conscious Sedation ,Humans ,Hypnotics and Sedatives ,Child ,Emergency Service, Hospital - Published
- 2007
61. [Management of intussusception in France in 2004: investigation of the Paediatric Infectious Diseases Group, the French Group of Paediatric Emergency and Reanimation, and the French Society of Paediatric Surgery]
- Author
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E, Grimprel, F, de La Rocque, O, Romain, P, Minodier, M-A, Dommergues, E, Laporte-Turpin, M, Lorrot, N, Parez, E, Caulin, M, Robert, H, Lehors, G, Chéron, C, Levy, and H, Haas
- Subjects
Patient Transfer ,Adolescent ,Enema ,Hospitals, General ,Pediatrics ,Hospitals, University ,Child, Preschool ,Surveys and Questionnaires ,Acute Disease ,Humans ,France ,Emergencies ,Child ,Emergency Service, Hospital ,Intussusception ,Ultrasonography - Abstract
To describe the different pathways of management of intussusception (IS) in infants and children in metropolitan France and to identify paediatric emergency centres that might constitute a surveillance network for IS.A questionnaire was sent to 273 paediatric emergency centres distributed across France in 2005. Modalities of diagnosis and treatment of IS had to be precised.One hundred and sixty-seven centres (61.2%) responded. The response was given by 131 paediatricians (78.4%) and 36 surgeons (21.6%) working in 38 universitary hospitals (22.7%) and 129 general hospitals (77.2%). The mean number of IS treated in each centre in 2004 was 11+/-13.5 (extr. 0 to 70; median 6). Diagnosis of IS required a collaboration between medical and surgical teams in 51.5% of the centres, but in 40.1% the sole medical team was in charge of the diagnosis. Ultrasonography is used for diagnosis by 98.8% of the centres. Reduction with hydrostatic enema and eventually surgery was performed in the same hospital in 44.3%. Other centres systematically or frequently transferred the patients for reduction, mostly towards universitary hospitals (90%).The procedures of IS diagnosis are the same everywhere in France but the pathways of therapeutic management do vary, depending on the availability of surgeons and anaesthetists trained in paediatrics on each site. These disparities will probably change with the implementation of the new plan for sanitary organization in children and adolescents in France. Labellized paediatric emergency centres will gather more surgical patients and could eventually constitute an effective surveillance network for IS.
- Published
- 2006
62. [Impact of CRP rapid test in management of febrile children in paediatric emergency units of Ile-de-France]
- Author
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R, Cohen, O, Romain, C, Levy, F, Perreaux, M, Decobert, I, Hau, A, Lécuyer, E, Lesprit, L, Maman, S, Roullaud, G, Chéron, A, Bekri, P, d'Athis, V, Henriquet, and F, de La Rocque
- Subjects
Chi-Square Distribution ,Time Factors ,Adolescent ,Fever ,Age Factors ,Infant, Newborn ,Infant ,Immunologic Tests ,Length of Stay ,Intensive Care Units, Pediatric ,C-Reactive Protein ,Child, Preschool ,Surveys and Questionnaires ,Humans ,Emergencies ,Child - Abstract
Fever is a common cause of children visits to emergency units. Clinical evaluation does not always eliminate a bacterial infection. Among blood markers, several publications showed the interest of CRP. This study was undertaken to evaluate correlation between two techniques of CRP, one by usual technique at the laboratory and the other by a rapid test, and to evaluate the impact of this rapid test for febrile children at the emergency room, when a hospitalization was not immediately decided.The study was undertaken in 2004-2005 in eight emergency paediatric units in Ile-de-France concerning febrile children during two periods. In period A, children had at the same time a CRP dosage through two methods, whereas in period B, only a rapid CRP test was first managed. The test used was NycoCard CRP Single test (Progen Biotechnique).Between September 2004 and June 2005, 572 children were included, 268 in period A and 304 in period B. Comparison of CRP results by the two methods showed for 247 children (93%) a fairly good linear correlation (r: 0.929). Blood cell count was the most often prescribed test (99.4 vs 10.5%). Conversely to chest radiography, blood culture, fibrinogen and urinary test were significantly most frequent in period A. The average cost of the additional examinations was 2.6 times more important during the first period. Duration of children management in the units was approximately two times shorter when rapid CRP test was used (199.7+/-92.8 vs 103.5+/-98.6 min).This study shows the interest of rapid CRP test for febrile children in the emergency units, and has to be confirmed in ambulatory paediatric practice.
- Published
- 2006
63. [Abdominal pain in children. Traps and diagnosis]
- Author
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G, Chéron, S, Faesch, and C, Chalouhi
- Subjects
Abdomen, Acute ,Patient Care Team ,Appendix ,Appendicitis ,Sensitivity and Specificity ,Abdominal Pain ,Diagnosis, Differential ,Humans ,France ,Child ,Tomography, X-Ray Computed ,Physical Examination ,Referral and Consultation ,Ultrasonography - Published
- 2006
64. [Medication errors in pediatric inpatients: a multicentric prospective study]
- Author
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C, Stheneur, J-B, Armengaud, C, Castro, G, Chéron, and B, Chevallier
- Subjects
Hospitalization ,Drug-Related Side Effects and Adverse Reactions ,Pharmaceutical Preparations ,Communication ,Surveys and Questionnaires ,Humans ,Medication Errors ,Clinical Competence ,France ,Prospective Studies ,Child - Abstract
To improve the knowledge of medication errors in paediatrics: rate of occurrence, error characteristics, risk factors.Our prospective study included nine uninformed teaching paediatric wards (general paediatrics, emergency departments, intensive care units) using a describing questionnaire built from medical reports analysis (event description, medical issues, contributing personal and structural factors) during a two-months period.Seventy-five questionnaires were collected and analysed. Medical errors reported concerned prescription: 21 cases and administration: 45 cases. Ten errors led to adverse effects. An attributable factor was noted in 39 cases. Concerning prescription errors, no respect to protocol: 11 cases, lack of knowledge: 3 cases, personal communication failure: 3 cases were noted. Concerning administration errors, human mistakes (lack of experience, miscommunication, calculation error): 8 cases, unclear prescription: 6 cases and system flaws: 6 cases were noted. Several attribuable causes were reported in 8 cases.Medication errors in paediatrics inpatients are common and contributing factors intricated. Paediatricians should help hospitals develop effective programs for safety providing medications, reporting medication errors, errors analysis strategy and creating a safe environment of medication for all hospitalised paediatric patients.
- Published
- 2005
65. [Prospective comparison of child asthma education in the emergency department and at scheduled follow-up consultation]
- Author
-
B, Cojocaru, J, de Blic, P, Scheinmann, and G, Chéron
- Subjects
Interviews as Topic ,Parents ,Paris ,Adolescent ,Patient Education as Topic ,Surveys and Questionnaires ,Quality of Life ,Humans ,Family ,Child ,Emergency Service, Hospital ,Asthma ,Follow-Up Studies - Abstract
To assess asthma control in asthmatic children attending the emergency department and to compare it with that for children with scheduled specialist follow-up.Between September 2002 and September 2003, we included asthmatic children aged 6 to 16 years, attending the emergency department (group U) or pulmonology follow-up appointments (group C) at Necker Hospital, Paris, France. We used the Asthma Therapy Assessment Questionnaire (ATAQ), completed by the parents and children aged 10 years and over.We interviewed 156 families and included 144 (92%) in the final analysis (77 in group U). The 2 groups did not differ in age, sex ratio, age at onset and asthma diagnosis and the frequency of asthma attacks. Children in group U received less daily maintenance treatment (P0.01) but reported more severe asthma (P0.05). They had also experienced fewer investigations for their asthma (fewer lung function tests P=0.01 and allergy tests P=0.001). The children in group C had better controlled asthma, as assessed by both the children themselves and their parents. They also had fewer problems relating to the behavior, communication and treatment control domains. The assessment of children and parents were similar in all areas except communication. The children considered their communication problems to be more serious than their parents did. Age-related differences were observed, with older children's parents having more difficulties in all domains investigated.Clinicians should consider assessing asthma control in children attending the emergency department. There is clearly an opportunity to improve the quality of asthma education for these children. Clinicians could provide children with a written plan of action for asthma attacks and information about daily self-management. Improving communication between children, their parents and doctors should be considered a key educational project.
- Published
- 2005
66. [Metered-dose inhaler with spacer vs nebulization for severe and potentially severe acute asthma treatment in the pediatric emergency department]
- Author
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N, Sannier, S, Timsit, B, Cojocaru, A, Leis, C, Wille, D, Garel, N, Bocquet, and G, Chéron
- Subjects
Male ,Chi-Square Distribution ,Time Factors ,Adolescent ,Nebulizers and Vaporizers ,Length of Stay ,Asthma ,Bronchodilator Agents ,Hospitalization ,Treatment Outcome ,Adrenal Cortex Hormones ,Child, Preschool ,Acute Disease ,Terbutaline ,Humans ,Albuterol ,Female ,Anti-Asthmatic Agents ,Prospective Studies ,Child ,Emergency Service, Hospital ,Inhalation Spacers - Abstract
To compare treatment with beta 2 agonist delivered either by a spacer device or a nebulizer in children with severe or potentially severe acute asthma.In this randomized trial, children 4 to 15 years, cared for in the emergency department for severe or potentially severe acute asthma, received 6 times either nebulizations of salbutamol (0.15mg/kg) or puffs of a beta 2 agonist (salbutamol 50 microg/kg or terbutaline 125 microg/kg). The primary outcome was the hospitalization rate. Secondary outcomes included percentage improvement in Bishop score, in PEF, SaO(2), respiratory and heart rates, side effects, length of stay and relapses 10 and 30 days later.Groups did not differ for baseline data. There were no significant differences between the 2 groups (nebulizer N=40, spacer N=39) for baseline characteristics before emergency department consultation except for length of acute asthma in the spacer group. Clinical evolution after treatment, hospitalization rate, relapse were similar including the more severe subgroup. In the spacer group, tachycardia was less frequent (P0.02). The overall length of stay in the emergency department was significantly shorter (148+/-20 vs 108+/-13 min, P10(-9)).The administration of beta 2 agonist using a metered-dose inhaler with spacer is an effective alternative to nebulizers for the treatment of children with severe or potentially severe acute asthma in the emergency department. Time gained can be used for asthma education.
- Published
- 2005
67. [Compliance with medication in children]
- Author
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H, Chappuy, J-M, Tréluyer, A, Gary, G, Pons, and G, Chéron
- Subjects
Humans ,Patient Compliance ,Child - Published
- 2005
68. [Informed consent in pediatric clinical trials]
- Author
-
H, Chappuy, A, Gary, G, Chéron, and J M, Tréluyer
- Subjects
Clinical Trials as Topic ,Informed Consent ,Humans ,Child - Published
- 2005
69. [Treatment of exacerbation of asthma: what are today's issues?]
- Author
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D, Ploin, A, Rousson, C, Vitoux-Brot, V, Nouyrigat, P, Foucaud, J-P, Lemaire, B, Chevallier, S, Bergeron, A, Martinot, G, Chéron, and D, Floret
- Subjects
Aerosols ,Evidence-Based Medicine ,Time Factors ,Primary Health Care ,Nebulizers and Vaporizers ,Adrenergic beta-Agonists ,Asthma ,Bronchodilator Agents ,Meta-Analysis as Topic ,Patient Education as Topic ,Adrenal Cortex Hormones ,Risk Factors ,Acute Disease ,Administration, Inhalation ,Practice Guidelines as Topic ,Humans ,Albuterol ,Family ,Anti-Asthmatic Agents ,Emergencies ,Child - Abstract
During past decades, major progress has been accomplished in the management of acute asthma. Most recent recommendations include evidence-based rationale. The improved quality of clinical guidelines makes them efficient models for medical education. The pediatric pharmacopoeia provides a great variety of choices of drugs as well as for asthma medical devices. These innovations dramatically facilitated the medical management of asthmatic children, but they did not solve all problems. Physicians now use higher doses of salbutamol, but the early prescription of systemic glucocorticoids for moderate exacerbation of asthma is still underused, given the most recent clinical guidelines and meta-analysis. Furthermore, repeated emergency department visits to the wards and lack of primary care physician should systematically be appraised when evaluating severity, as they are both major risk factors for severe exacerbations, even though they are not considered in acute asthma severity scores. Finally, initiating (or reinforcing) patient education at the time of exacerbation also presents important challenges, as emergency visits are a favorable moment to commence the therapeutic education of the child and his family. Indeed, framing the controller medications and educating families about how to manage the disease and to improve their domestic environment are the genuine tools available for the prevention of asthma exacerbations, and particularly those most severe.
- Published
- 2005
70. [Apparent life threatening event in infants]
- Author
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G, Chéron, B, Cojocaru, and S, Timsit
- Subjects
Death, Sudden ,Critical Illness ,Humans ,Infant ,Severity of Illness Index - Published
- 2004
71. [Acute osteomyelitis and septic arthritis in children: one year experience]
- Author
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S, Timsit, S, Pannier, C, Glorion, and G, Chéron
- Subjects
Male ,Arthritis, Infectious ,Adolescent ,Child, Preschool ,Acute Disease ,Humans ,Infant ,Female ,Osteomyelitis ,Child ,Retrospective Studies - Abstract
To describe bacteriologic epidemiology of bone and joint infections, a total of 52 osteomyelitis, 52 arthritis and 20 osteoarthritis of children aged one month to 15 years during a one-year period (2001) were included in a retrospective unicentric review. The mean age was 3,9 +/-3,6 years. Fever and pain were the most common clinical symptoms. The site of infection was single in 95%, involving lower extremities in 80%. Bone scintigraphy was abnormal in 71% of osteomyelitis. Positive cultures was obtained in 29% of all cases (blood cultures: 20%, aspiration cultures: 29%), but in 42% of cases which have both blood and aspiration cultures. Thirty-six bacteria were identified: 19 Staphylococcus (14 aureus), ten Streptococcus (four pneumoniae), three Salmonella, three Kingella kingae, one Moraxella. All the isolates were susceptible to the empiric antibiotic therapy. Outcome was good in 100% of osteomyelitis and in 96% of arthritis.
- Published
- 2004
72. [Oral morphine administration for children's traumatic pain]
- Author
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C, Wille, N, Bocquet, B, Cojocaru, A, Leis, and G, Chéron
- Subjects
Arm Injuries ,Time Factors ,Adolescent ,Morphine ,Age Factors ,Administration, Oral ,Infant ,Pain ,Analgesics, Opioid ,Fractures, Bone ,Child, Preschool ,Data Interpretation, Statistical ,Humans ,Wounds and Injuries ,Prospective Studies ,Emergencies ,Child ,Leg Injuries ,Pain Measurement - Abstract
To study the compliance of prescription, the efficacity and the adverse events of oral morphine used in the pediatric emergency department (ED) in traumatic pains.This prospective study was conducted in the ED from october 2002 to september 2003. Children aged six months to 16 years with a visual analogic scale (VAS) score higher than 70 or with a traumatic member deformation received oral morphine (0,5 mg/kg). Pain was assessed every 30 minutes using two scales: behavioral observation by the faces scale and objective pain scale (OPS) for children less than five years, behavioral observation by the faces scale and self-report by VAS for children older than five years. The compliance of prescription, the pain scores and the adverse events were studied.Ninety-one children received oral morphine and seventy-four children were studied. Seventy per cent of prescriptions were in accordance with the recommendations. For patients younger than five years a rapid decrease of pain was observed in thirty minutes. The pain's reduction was respectively 79 and 84% with faces scale and OPS when they left ED. For children older than five years, pain's reduction was more important and more rapid when pain assessment was made by nurses than when it was self-reported in the first hour (pain reduction 58,2 and 36,1%). When leaving, pain reduction was the same with the two different assessments. No major adverse event was noted.Use of oral morphine in ED is simple, with a few numbers of adverse events. None was severe. Efficiency is correct after 30 to 60 minutes.
- Published
- 2004
73. [Post-traumatic lower limb pain in children]
- Author
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B, Cojocaru, G, Chéron, and C, Glorion
- Subjects
Humans ,Pain ,Child ,Leg Injuries - Abstract
Injuries to the lower extremity are frequent. They present as pain, reduction of joint function, alteration in gait. Most of the orthopaedic emergencies for teenagers are related to trauma. For younger children, a history of recent fall is prevalent but the non traumatic orthopaedic conditions are especially important to investigate when the reported injury is minor or when onset of symptoms is delayed.
- Published
- 2004
74. [Pediatric emergency department policy. Implementation and management of the resuscitation room]
- Author
-
G, Chéron, J L, Chabernaud, S, Dalmas, D, Floret, P, Leveau, P, Mardegan, A, Martinot, V, Massol, J M, Minguet, G, Orliaguet, L, Pédespan, and E, Wodey
- Subjects
Humans ,France ,Child ,Emergency Service, Hospital ,Intensive Care Units, Pediatric ,Organizational Policy ,Societies, Medical - Abstract
The pediatric resuscitation room is the place where children suffering from vital distress are cared for in the emergency unit. Recommendations for its organization, functioning and evaluation have been ruled on by experts from six medical societies involved in these emergencies. They concern all the hospital's physicians, nurses and administrative directors.
- Published
- 2004
75. [Analgesia in the pediatric emergency department]
- Author
-
G, Chéron, B, Cojocaru, and N, Bocquet
- Subjects
Analgesics ,Conscious Sedation ,Humans ,Pain ,Child ,Emergency Service, Hospital ,Pediatrics ,Half-Life - Abstract
Pain concerns more than 50% of the children cared in the emergency unit. After evaluation, it has to be cured with drugs adapted to its level and its origin. Residual pain needs therapeutic adjustment. The goal is to allow the child to restart his activities. A preventive sedation analgesia is necessary when a painful exam is to be performed, either for diagnosis or therapeutic purpose. For this goal ideal analgesics, either for monotherapy or associated, are easily and painlessly administered. They have rapid onset of action, brief half-life, predictable, effective analgesic properties without side effects and they are quickly reversible. These drugs do not exist and every sedation procedure has a risk of hypoxemia. With the human and equipment's investment an emergency department should be able to ensure that procedures are performed in children under sedation with a standard of safety that is similar to general anaesthesia. The main drawback in a well-organised system should be a significant children's rate for which general anaesthesia is preferred.
- Published
- 2004
76. Cerebrospinal fluid penetration of amikacin in children with community-acquired bacterial meningitis
- Author
-
C. Silly, Philippe Hubert, B Mahut, F Lacaille, V Matha, Véronique Abadie, C Coustere, Jean-Louis Gaillard, A Le Masne, and G. Chéron
- Subjects
Male ,medicine.medical_specialty ,CSF glucose ,Gastroenterology ,Meningitis, Bacterial ,Cerebrospinal fluid ,Pharmacokinetics ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Child ,Amikacin ,Antibacterial agent ,Pharmacology ,business.industry ,Infant ,Liter ,medicine.disease ,Surgery ,Community-Acquired Infections ,Glucose ,Infectious Diseases ,Child, Preschool ,Cerebrospinal fluid penetration ,Female ,business ,Meningitis ,Research Article ,medicine.drug - Abstract
The penetration of amikacin into the cerebrospinal fluid (CSF) was studied with 16 children (mean age, 1 year and 9 months; range, 4 months to 8 years) with community-acquired bacterial meningitis. Amikacin was given intravenously at a dose of 7.5 mg/kg of body weight twice daily. CSF was collected on day 1, at the expected peak concentration of amikacin in CSF. The mean (standard deviation) concentration of amikacin in CSF was 1.65 (1.6) mg/liter. Concentrations of amikacin in CSF correlated significantly with CSF glucose levels on admission. The mean concentrations of amikacin in CSF were 2.9, 1.1, and 0.20 mg/liter in patients with CSF glucose levels of < 1, 1 to 2, and > 2 mmol/liter, respectively. Thus, amikacin penetrates the blood-brain barrier substantially in children with bacterial meningitis and achieves particularly high concentrations when CSF glucose level is < 1 mmol/liter on admission.
- Published
- 1995
77. [Hematemesis in an 11-month-old child: an unusual symptom revealing a foreign body in the stomach]
- Author
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N, Bocquet, L, Guillot, J F, Mougenot, F M, Ruemmele, and G, Chéron
- Subjects
Stomach ,Humans ,Infant ,Female ,Hematemesis ,Foreign Bodies - Abstract
Ingestion of foreign body has often no consequence. We report on a case in an 11-month-old girl who was referred for mild hematemesis and anorexia. Upper digestive tract endoscopy found a small metallic foreign body in the gastric antrum. After its removal, all symptoms disappeared. It is usually recommended to remove foreign bodies by endoscopy when they are in esophageal position, or are more than 3 to 5 cm long, or have a shape that may hurt the gut mucosa. Although rare, a gastric foreign body should be searched for in face of an upper gastrointestinal bleeding in an infant.
- Published
- 2003
78. [Central nervous system tumor: an unusual etiology for limb pain]
- Author
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W, Gueddari, D, Garel, C, Barnerias, B, Cojocaru, C, Sainte Rose, and G, Chéron
- Subjects
Central Nervous System Neoplasms ,Male ,Brain Neoplasms ,Child, Preschool ,Humans ,Infant ,Pain ,Female ,Magnetic Resonance Imaging - Abstract
Limb pain in children is one of the most frequent reasons to refer to the emergency unit. Most often it suggests an orthopaedic, a muscular, a peripheral neurologic or a spinal affection. We report two cases of recurrent limb pains revealing a central nervous system tumor.
- Published
- 2003
79. [Angelman syndrome: clinical and genetic model]
- Author
-
B, Dan and G, Chéron
- Subjects
Chromosomes, Human, Pair 15 ,Epilepsy ,Cerebral Palsy ,Mental Disorders ,Ubiquitin-Protein Ligases ,Electroencephalography ,Speech Disorders ,Diagnosis, Differential ,Ligases ,Phenotype ,Intellectual Disability ,Humans ,Point Mutation ,Angelman Syndrome ,Psychomotor Disorders - Abstract
Angelman syndrome is a neurogenetic disorder characterized by developmental delay, absence of speech, motor impairment, epilepsy and a peculiar behavioural phenotype associated with abnormalities of chromosome 15q11-13. Precise diagnosis carries clinical and genetic counseling implications. However, many clinicians still seem unfamiliar with it despite the severity and typical aspects of presentation. Beyond individual situations, Angelman syndrome can serve as a model opening broad questioning of genetic and epigenetic influences in neurology, as well as of several concepts such as psychomotor development, cerebral palsy, behavioural phenotypes and epileptic syndromes. Recent advances in molecular biology and animal models of the syndrome provide new data which must be included in our interpretation of Angelman syndrome.
- Published
- 2003
80. [Smoking and sudden infant death syndrome]
- Author
-
G, Chéron and S, Timsit
- Subjects
Nicotine ,Bias ,Pregnancy ,Risk Factors ,Prenatal Exposure Delayed Effects ,Smoking ,Humans ,Infant ,Female ,Receptors, Nicotinic ,Pulmonary Ventilation ,Sudden Infant Death - Abstract
Assessment of the causation relationship between two phenomena requires the demonstration of an epidemiological association, a temporal and asymmetric sequence, and a biological gradient and identification of the biological mechanism(s). All epidemiological studies on sudden infant death syndrome (SIDS) and smoking have encountered major bias and difficult data interpretation but they all have estimated that maternal smoking caused a 2 to 3-fold increased risk of SIDS. Nicotine may interact with non-neuronal nicotinic receptors in the lung, peripheral nicotinic cholinergic and adrenergic chemoreceptors, and brainstem nuclei and has been largely studied. More accurate knowledge concerning the biochemistry and specific features of nicotinic receptors will be useful to explain the way nicotine alters breathing at rest and during hypoxia. Uncertainty about the casual relationship in no way means the fight against smoking is not warranted.
- Published
- 2003
81. [Mucolytic agents for acute respiratory tract infections in infants: a pharmacoepidemiologic problem?]
- Author
-
M, Chalumeau, G, Chéron, R, Assathiany, F, Moulin, F, Bavoux, G, Bréart, and G, Pons
- Subjects
Male ,Carbocysteine ,Health Care Surveys ,Infant, Newborn ,Humans ,Infant ,Female ,France ,Prospective Studies ,Practice Patterns, Physicians' ,Acetylcysteine ,Expectorants - Abstract
To study the use of mucolytics agents, i.e. acetylcystein and carbocystein, in infants. To evaluate their efficacy and safety for their main indications.A prospective one-day survey of prescriptions among 95 office-based pediatricians. A systematic review of the literature.Among 1327 prescriptions regarding infants, 4.3% were mucolytics agents. Main indications were rhinopharyngitis, isolated cough, and acute bronchitis. Our review did not identify any study of rigorous methodological quality that supported the efficacy or safety of mucolytics agents in infants for their in-label (isolated cough, acute bronchitis) and off-label (rhinopharyngitis) indications. Six cases of infants, aged less than eight months, presenting paradoxical bronchial congestion during a treatment with mucolytics agents, have been reported to the French pharmacovigilance system. No causal relationship was established from these cases because of a possible protopathic bias.Our results concerning mucolytics agents use are similar to those reported by the French Health Care Funds. In addition to the lack of studies on efficacy, no studies on the dose-response relationship were available, leading to suggested dose regimens in the French license of acetylcystein ranging from 44.4 to 16.4 mg kg-1 j-1 between one to 24 months. These dose regimens could predispose to overdosing in the youngest infants as it seems observed in the six reported cases.In infants, mucolytics agents efficacy has never been demonstrated and some elements suggest poor safety (paradoxical bronchial congestion).
- Published
- 2002
82. [Effect of racecadotril in the management of acute diarrhea in infants and children]
- Author
-
B, Cojocaru, N, Bocquet, S, Timsit, C, Wille, C, Boursiquot, F, Marcombes, D, Garel, N, Sannier, and G, Chéron
- Subjects
Diarrhea ,Male ,Emergency Medical Services ,Thiorphan ,Dehydration ,Infant ,Water-Electrolyte Balance ,Treatment Outcome ,Child, Preschool ,Acute Disease ,Fluid Therapy ,Humans ,Female ,Antidiarrheals - Abstract
The treatment of diarrhoea relies on the maintenance or restoration of hydration with maintenance of an adequate nutritional intake. Racecadotril has been shown to reduce the stools output during acute diarrhoea. The present work was aimed at measuring the number of emergency department visits for acute diarrhoea either the children received racecadotril or not.Racecadotril and rehydration were compared with rehydration alone in children aged three months to three years who had acute diarrhoea and were evaluated in the emergency department (ED). The primary end point was the number of medical exams during the week after starting treatment. Secondary end points were the number of stools during the first 48 hours, the duration of the diarrhoea and the weight on day 7.One hundred and sixty-six children were alternatively randomized to the treated and the control groups. There was no difference for age, degree of dehydration and length of illness before the first visit between the groups. Whatever type of rehydration (oral or i.v.), the treated group had a significant lower number of stools (p0.001) and a faster recovery (p10(-9)). The children receiving racecadotril needed less additional ED visits for the same episode (p0.05). There was no difference for the weight-gain on day 7.This study demonstrates the efficacy of racecadotril as adjuvant therapy to oral and i.v. rehydration in the treatment of acute diarrhoea and a fewer emergency department second visit before recovery.
- Published
- 2002
83. [Benefits of ipratropium bromide in the management of asthmatic crises in the emergency department]
- Author
-
S, Timsit, N, Sannier, N, Bocquet, B, Cojocaru, C, Wille, C, Boursiquot, D, Garel, F, Marcombes, and G, Chéron
- Subjects
Male ,Chi-Square Distribution ,Adolescent ,Ipratropium ,Nebulizers and Vaporizers ,Status Asthmaticus ,Adrenergic beta-Agonists ,Cholinergic Antagonists ,Bronchodilator Agents ,Hospitalization ,Random Allocation ,Child, Preschool ,Odds Ratio ,Humans ,Albuterol ,Female ,Prospective Studies ,Child ,Emergency Service, Hospital - Abstract
To determine if the addition of ipratropium bromide in the emergency department (ED) for the treatment of childhood asthma reduces rates of hospitalization and relapses for moderate and severe exacerbations.Patients were given an oral corticosteroid treatment (2 mg/kg) and received every 20 minutes either three nebulizations with albuterol (0.15 mg/kg) and ipratropium bromide (250 micrograms) or six nebulizations with albuterol alone (control group). The primary end point was the need for hospitalization, additional nebulizations or a relapse during the following week. Secondary end point included the effect of age.One hundred and forty three children, two to 15 years old, were randomized to ipratropium or control groups and 121 were evaluated on day seven. As a whole, the control group was less often hospitalized or in relapse than those treated with three nebulizations of albuterol and ipratropium (17.5% vs 37.9%, p0.02). The ipratropium group reached the same result after three additional albuterol nebulizations. The benefit of anticholinergic therapy was observed for children less than six years of age who had a similar rate of success (73.5 vs 75.7%).The association of ipratropium bromide to the first three doses of the albuterol protocol for acute asthma did not act as well as six nebulizations of albuterol alone. The effect was age dependent and two to six years old children needed more attention. Nevertheless the hospitalization rate did not support the use of ipratropium compared with repeated albuterol nebulizations.
- Published
- 2002
84. [Drugs for pediatric emergencies]
- Author
-
G, Chéron, N, Bocquet, S, Timsit, and B, Cojocaru
- Subjects
Drug Therapy ,Cardiovascular Diseases ,Respiratory Tract Diseases ,Emergency Medicine ,Humans ,Pain ,Nervous System Diseases ,Child ,Pediatrics - Abstract
Drugs for pediatric emergencies are useful for respiratory (croup, asthma), cardiologic (hypertensive crisis, acute congestive heart failure, arrhythmias, hypoxic spells), neurologic (seizures), metabolic (dehydration, hypoglycaemia), infectious (meningococcemia) or allergic (anaphylaxis) distresses. Pain management is always important whether to relieve or to prevent the discomfort which would happen during diagnosis or therapeutic procedures.
- Published
- 2002
85. Les Annales françaises de médecine d’urgence, la médecine d’urgence pédiatrique et Toulouse récompensés !
- Author
-
G. Chéron and B. Riou
- Subjects
business.industry ,Emergency Medicine ,Medicine ,business ,Humanities - Published
- 2011
86. Pneumothorax chez un nourrisson avec bronchiolite aiguë
- Author
-
J. Chavagnat, S. Miramont, and G. Chéron
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Anesthesiology ,Emergency Medicine ,Medicine ,business - Published
- 2011
87. Des recommandations et de la pratique de l’anesthésie de l’enfant en situation d’urgence : réponse
- Author
-
Benoît Vivien, G. Chéron, J.-E. de La Coussaye, Gilles Orliaguet, and J.-F. Diependaele
- Subjects
Anesthesiology and Pain Medicine ,General Medicine - Published
- 2011
88. [Assessing the cost of the first episode of bronchiolitis]
- Author
-
N, Sannier, N, Bocquet, S, Timsit, B, Cojocaru, C, Wille, D, Garel, C, Boursiquot, and G, Chéron
- Subjects
Male ,Cost of Illness ,Child, Preschool ,Costs and Cost Analysis ,Infant, Newborn ,Bronchiolitis ,Humans ,Infant ,Female - Abstract
Each year, a quarter of the children younger than 24 months has respiratory syncytial virus bronchiolitis. The morbidity among high-risk infants and the possible association with the development of asthma lead to propose preventive measures whose cost-effectiveness relationship is unknown. The present work was aimed at measuring costs of a first attack of bronchiolitis.For children less than two years visited in the emergency department, direct and indirect costs were measured according to the 'Sécurité Sociale' prices. Associated morbidity, the management of care (inpatient versus outpatient), outpatients' outcome two weeks after the visit, socioeconomic data were recorded.One hundred eighty three children have been studied. The length of stay for 40 hospitalizations was 7.6 +/- 4.3 days. Direct costs were 37,200 +/- 22,000 FF for inpatients, and 1286 +/- 633 F for outpatients. For 113 outpatients' families, indirect costs were 49 working days lost. The way the child was looked after and the unemployment rate in the study were similar to data provided by the National Institute of Statistics and Economic Studies.Because of the variability of the hospitalization rate from one setting to another, overall costs of the epidemic cannot be evaluated. For the policymaker, the greatest costs come from the outpatient care. Others studies will be necessary to evaluate the price of future preventive measures.
- Published
- 2001
89. [Hospitalization criteria in emergency asthmatic+ crises]
- Author
-
N, Sannier, S, Timsit, C, Boursiquot, D, Garel, N, Bocquet, and G, Chéron
- Subjects
Hospitalization ,Risk Factors ,Humans ,Emergencies ,Child ,Severity of Illness Index ,Asthma - Published
- 2001
90. [Vitamin D status of pregnant Palestinian women]
- Author
-
J C, Souberbielle, M, al Masri, and G, Chéron
- Subjects
Adult ,Pregnancy Complications ,Cultural Characteristics ,Social Class ,Pregnancy ,Incidence ,Age Factors ,Humans ,Female ,Israel ,Vitamin D Deficiency - Published
- 2001
91. [Infant diseases]
- Author
-
G, Chéron
- Subjects
Male ,Emergency Medical Services ,Recurrence ,Bradycardia ,Gastroesophageal Reflux ,Infant, Newborn ,Humans ,Infant ,Female ,Prognosis ,Severity of Illness Index ,Infant, Newborn, Diseases - Abstract
Apparent life-threatening events in an infant require: 1/ to determine the seriousness of the event; 2/ to identify its etiology; 3/ to evaluate the risk of recurrence and the need for appropriate preventive measures. Management mainly depends upon the determination of the etiology and the understanding of the pathogenetic mechanism. Gastroesophageal reflux is the main etiology. Therefore whenever symptoms of gastroesophageal reflux are present, this has to be considered as the first etiological hypothesis. Other etiologies will be searched for if orientating symptoms or anamnesis information is present, leading to specific investigations.
- Published
- 2001
92. Ambulatory management of acute pyelonephritis in children
- Author
-
N, Sannier, A, Le Masne, N, Sayegh, J L, Gaillard, and G, Chéron
- Subjects
Male ,Pyelonephritis ,Child, Preschool ,Acute Disease ,Ambulatory Care ,Humans ,Female ,Child - Published
- 2000
93. ['Life threatening events in infancy': plea for a semiologic approach and rationalization of examinations]
- Author
-
G, Chéron and N, Sannier
- Subjects
Quality Assurance, Health Care ,Critical Illness ,Gastroesophageal Reflux ,Infant, Newborn ,Humans ,Infant ,Prognosis ,Pediatrics ,Sudden Infant Death - Published
- 1999
94. Bronchiolite del lattante
- Author
-
G. Chéron
- Published
- 2007
95. [Epidemiologic survey of infants hospitalized for bronchiolitis. Survey conducted by the ERBUS medical network]
- Author
-
B, Thélot, J J, Bénichou, G, Chéron, B, Chevallier, P, Bégué, and A, Bourrillon
- Subjects
Male ,Epidemiologic Studies ,Paris ,Bronchiolitis ,Humans ,Infant ,Female ,Seasons ,Sex Ratio ,Hospitals, Pediatric ,Child, Hospitalized ,Severity of Illness Index - Abstract
Acute infant bronchiolitis is a frequent seasonal disease which peaks in December. It often requires hospital care in Paris and in its surroundings. The exceptional bronchiolitis epidemic of December 1991 brought about a temporary saturation of hospital bed space at the Assistance Publique-Hôpitaux de Paris (AP-HP). Hereafter, in order to organize care more efficiently, an epidemiological observation network called ERBUS was set up.Thanks to daily reports of emergency pediatric admissions through the Minitel network, it has been possible to get real time information on the course of the past five epidemics in each of the 11 AP-HP hospitals with pediatric emergency units.Globally the results point to a similar situation every year: approximately 60% boys, 35% babies under 6 months; the ratio of very young patients who are admitted to hospital is multiplied by 1.5 at the mid-point of and at the end of the epidemic compared with the beginning; 70% of the babies under 3 months are admitted to hospital. The ratio of patients who come and are admitted to hospital has been on the decrease every year since 1991: globally from 36.8% down to 28.6% in five years (from 75.1% down to 65.3% among babies under 3 months). The rhythm and intensity of the epidemic have risen sharply: in five years, the number of patients has increased by 119% and that of patients admitted to hospital by 69%, while the epidemic peaks are earlier and higher.These statistics have actually been used to allocate additional resources in AP-HP hospitals during the epidemics. To avoid the saturation of bed space in the future, ambulatory care of patients not admitted to hospital should be favored.
- Published
- 1998
96. [Anti-infective treatment of acute pneumopathies in children]
- Author
-
A, Le Masne, M, Chalumeau, and G, Chéron
- Subjects
Lung Diseases ,Cross Infection ,Child, Preschool ,Acute Disease ,Humans ,Infant ,Child ,Respiratory Tract Infections ,Anti-Bacterial Agents - Published
- 1997
97. [Radiological case of the month. Neonatal proximal tibial epiphyseal detachment]
- Author
-
A, Le Masne, J F, Quignodon, P, Mary, and G, Chéron
- Subjects
Male ,Radiography ,Tibia ,Birth Injuries ,Infant, Newborn ,Humans ,Knee Injuries ,Epiphyses - Published
- 1997
98. Signe (ou syndrome) de Chilaiditi
- Author
-
G. Chéron, S. Sidorkiewicz, and V. Nouyrigat
- Subjects
business.industry ,Emergency Medicine ,Medicine ,business - Published
- 2013
99. Urgences chirurgicales de l’enfant
- Author
-
G. Chéron
- Subjects
medicine.medical_specialty ,business.industry ,Anesthesiology ,Emergency Medicine ,Medicine ,Medical emergency ,business ,medicine.disease - Published
- 2013
100. [Treatment of acute heart failure in infants]
- Author
-
G, Chéron and A, Le Masne
- Subjects
Heart Failure ,Cardiotonic Agents ,Vasodilator Agents ,Acute Disease ,Age Factors ,Humans ,Infant ,Diuretics - Abstract
The treatment of congestive heart failure in infants must be etiological and symptomatic. Vasodilators, inotropic agents and diuretics are the main therapeutics used in the symptomatic treatment. Guidelines for the emergency treatment according to the main etiologies are presented.
- Published
- 1996
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