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455 results on '"Gündel H"'

52. Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019

Author

Hedvig Glans, Leif Dotevall, Gert Van der Auwera, Aldert Bart, Johannes Blum, Pierre Buffet, Romain Guery, Jean-Pierre Gangneux, Saskia van Henten, Gundel Harms, Stefania Varani, Florence Robert-Gangneux, Robert Rongisch, Björn Andersson, and Maria Bradley

Subjects
Cutaneous leishmaniasis, Leishmania major, Leishmania tropica, Treatment, Outcome, Infectious and parasitic diseases, RC109-216
Abstract

ABSTRACT: Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe. Methods: We conducted a retrospective study of parasitological confirmed CL cases caused by L. major and L. tropica during 2013-2019 in Europe. Data were collected from medical records and databases within the LeishMan network. Results: Of 206 included cases of CL, 75 were identified as L. major and 131 as L. tropica. Of patients with L. tropica infection, 80% were migrants, whereas 53% of patients with L. major infection had been visiting friends and relatives. Among patients with L. tropica, 48% were younger than 15 years. Pentavalent antimony cured 73% (L. major) and 78% (L. tropica) of patients. The cure rate for intralesional administration was 86% and 67% for systemic, on L. tropica. Liposomal amphotericin B had a cure rate of 44-63%. Conclusion: L. major infections were mostly found in individuals visiting friends and relatives, whereas L. tropica were mainly identified in migrants. No patients with L. major relapsed. Pentavalent antimony, liposomal amphotericin B, and cryotherapy had cure rates in accordance with previous studies.

Published
2022
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57. Psychische und psychosomatische Erkrankungen von Beschäftigten – zur Qualität der Zusammenarbeit an den Schnittstellen der Versorgung

Author

Michaelis, M, Junne, F, Rothermund, E, Gündel, H, Zipfel, S, Shahriari, R, and Rieger, MA

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Hintergrund: Die Prävention psychischer und psychosomatischer Erkrankungen (PPE) in der Arbeitswelt wird zunehmend bedeutsamer. Arbeitsplatzbezogene Präventions-, Rehabilitations- und Wiedereingliederungsmaßnahmen sind Beispiele für überlappende Arbeitsgebiete von Betriebsärzten[zum vollständigen Text gelangen Sie über die oben angegebene URL], 14. Deutscher Kongress für Versorgungsforschung

Published
2015
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74. Brief psychodynamic interpersonal psychotherapy for patients with multisomatoform disorder: randomised controlled trial.

Author

Sattel, H., Lahmann, C., Gündel, H., Guthrie, E., Kruse, J., Noll-Hussong, M., Ohmann, C., Ronel, J., Sack, M., Sauer, N., Schneider, G., Henningsen, P., and Gündel, H

Subjects
PSYCHODYNAMIC psychotherapy, INTERPERSONAL relations, SOMATIZATION disorder, QUALITY of life, PSYCHIATRIC research
Abstract

Background: Multisomatoform disorder is characterised by severe and disabling bodily symptoms, and pain is one of the most common and impairing of these. Furthermore, these bodily symptoms cannot be explained by an underlying organic disorder. Patients with multisomatoform disorder are commonly found at all levels of healthcare and are typically difficult to treat for physicians as well as for mental health specialists.Aims: To test whether brief psychodynamic interpersonal therapy (PIT) effectively improves the physical quality of life in patients who have had multisomatoform disorder for at least 2 years.Method: We recruited 211 patients (from six German academic outpatient centres) who met the criteria for multisomatoform disorder for a randomised, controlled, 12-week, parallelgroup trial from 1 July 2006 to 1 January 2009 (International Standard Randomised Controlled Trial Number ISRCTN23215121). We randomly assigned the patients to receive either 12 weekly sessions of PIT (n = 107) or three sessions of enhanced medical care (EMC, n = 104). The physical component summary of the Short Form Health Survey (SF-36) was the pre-specified primary outcome at a 9-month follow-up.Results: Psychodynamic interpersonal therapy improved patients' physical quality of life at follow-up better than EMC (mean improvement in SF-36 score: PIT 5.3, EMC 2.2), with a small to medium between-group effect size (d = 0.42, 95% CI 0.15-0.69, P = 0.001). We also observed a significant improvement in somatisation but not in depression, health anxiety or healthcare utilisation.Conclusions: This trial documents the long-term efficacy of brief PIT for improving the physical quality of life in patients with multiple, difficult-to-treat, medically unexplained symptoms. [ABSTRACT FROM AUTHOR]

Published
2012
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75. Clinical diversity and treatment results in Tegumentary Leishmaniasis: A European clinical report in 459 patients.

Author

Romain Guery, Stephen L Walker, Gundel Harms, Andreas Neumayr, Pieter Van Thiel, Jean-Pierre Gangneux, Jan Clerinx, Sara Karlsson Söbirk, Leo Visser, Laurence Lachaud, Mark Bailey, Aldert Bart, Christophe Ravel, Gert Van der Auwera, Johannes Blum, Diana N Lockwood, Pierre Buffet, and LeishMan Network and the French Cutaneous Leishmaniasis Study group

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

BackgroundCutaneous leishmaniasis (CL) is frequent in travellers and can involve oro-nasal mucosae. Clinical presentation impacts therapeutic management.MethodologyDemographic and clinical data from 459 travellers infected in 47 different countries were collected by members of the European LeishMan consortium. The infecting Leishmania species was identified in 198 patients.Principal findingsCompared to Old World CL, New World CL was more frequently ulcerative (75% vs 47%), larger (3 vs 2cm), less frequently facial (17% vs 38%) and less frequently associated with mucosal involvement (2.7% vs 5.3%). Patients with mucosal lesions were older (58 vs 30 years) and more frequently immunocompromised (37% vs 3.5%) compared to patients with only skin lesions. Young adults infected in Latin America with L. braziliensis or L. guyanensis complex typically had an ulcer of the lower limbs with mucosal involvement in 5.8% of cases. Typically, infections with L. major and L. tropica acquired in Africa or the Middle East were not associated with mucosal lesions, while infections with L. infantum, acquired in Southern Europe resulted in slowly evolving facial lesions with mucosal involvement in 22% of cases. Local or systemic treatments were used in patients with different clinical presentations but resulted in similarly high cure rates (89% vs 86%).Conclusion/significanceCL acquired in L. infantum-endemic European and Mediterranean areas displays unexpected high rates of mucosal involvement comparable to those of CL acquired in Latin America, especially in immunocompromised patients. When used as per recommendations, local therapy is associated with high cure rates.

Published
2021
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