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51. Puerperium-related Stroke Due to Nonbacterial Thrombotic Endocarditis

Author

Chacón-Díaz, Manuel, Ruiz-Cordero, Roberto, Miranda-Aguilar, Helard, Rios-Ortega, Josias, Córdova-Gómez, Fernando, and Morón-Castro, Julio

Subjects
Adult, Brain Ischemia, Cardiac Surgical Procedures, Cesarean Section, Echocardiography, Transesophageal, Emergency Service, Hospital, Endocarditis, Non-Infective, Female, Humans, Postpartum Period, Pre-Eclampsia, Pregnancy, Prognosis, Stroke, Thrombosis, Treatment Outcome
Published
2019

56. Reinstatement of the genus <italic>Coenobiodiscus</italic> for the distinctive colonial diatom <italic>Planktoniella muriformis</italic> (Bacillariophyta)

Author

Gómez, Fernando, Zhang, Huan, Navarrete-Carlos, Tania Corina, Raymond, Eugenio, Tekle, Yonas I., López-Osorio, Yahir Enrique, Salas, Rafael, Alonso-Rodríguez, Rosalba, and Lin, Senjie

Subjects
*GENETIC distance, *PHYLOGENY, *THALASSIOSIRA, *MORPHOLOGY, *SPECIES
Abstract

Planktonic diatoms of the genus Planktoniella are characterized by organic extensions from the girdle. Planktoniella species are solitary, except for a colonial form that was first described as Coenobiodiscus muriformis from San Diego Bay, California. We established a culture of Planktoniella muriformis from Mazatlán, Gulf of California, in order to solve its phylogenetic affinities using molecular markers. Beyond the distinct colony morphology, P. muriformis has one marginal rimoportula and absence of mantle ribs, while two rimoportulae and numerous mantle ribs are the signature characteristics in the solitary species of the genus Planktoniella. In the SSU-, LSU rRNA and RuBisCO large subunit (rbcL) gene phylogenies, P. muriformis is nested within sequences from the paraphyletic genus Thalassiosira. The sequences are distantly related to the clade of the type species of Planktoniella, P. sol, and four other congeneric species, and the type species of Thalassiosira or any other thalassiosiroid genera, supporting consideration as an independent genus. In the rbcL gene phylogeny, the sequence of P. muriformis allies with distinct thalassiosiroid genera without bootstrap support, while in the SSU and LSU rRNA gene phylogenies it is nested with support as a sister group of two strains of T. hispida or the strain BEN02-35 identified as Thalassiosira angulata, respectively. The considerable genetic distance between these taxa and P. muriformis, and the lack of distinctive common morphological features do not support their placement in the same genus. Based on analyses of nuclear and chloroplast molecular markers, and the distinctive morphology of P. muriformis, with a unique type of colony formation unknown in any other diatom, we reinstate the genus Coenobiodiscus for P. muriformis. [ABSTRACT FROM AUTHOR]

Published
2025
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57. Controlled Flavour Changing Neutral Couplings in Two Higgs Doublet Models

Author

Alves, Joao M., Botella, Francisco J., Branco, Gustavo C., Cornet-Gomez, Fernando, and Nebot, Miguel

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

We propose a class of Two Higgs Doublet Models where there are Flavour Changing Neutral Currents (FCNC) at tree level, but under control due to the introduction of a discrete symmetry in the full Lagrangian. It is shown that in this class of models, one can have simultaneously FCNC in the up and down sectors, in contrast to the situation encountered in BGL models. The intensity of FCNC is analysed and it is shown that in this class of models one can respect all the strong constraints from experiment without unnatural fine-tuning. It is pointed out that the additional sources of flavour and CP violation are such that they can enhance significantly the generation of the Baryon Asymmetry of the Universe, with respect to the Standard Model., Comment: 29 pages, 3 figures

Published
2017
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67. Ex-Post Fairness Controls and Contract Design: The Spanish Experience

Author

Gómez, Fernando, Artigot, Mireia, Mathis, Klaus, Series Editor, Chiassoni, Pierluigi, Editorial Board Member, Cserne, Péter, Editorial Board Member, Deffains, Bruno, Editorial Board Member, Eger, Thomas, Editorial Board Member, Golecki, Mariusz J., Editorial Board Member, Heinemann, Andreas, Editorial Board Member, Lanneau, Régis, Editorial Board Member, Portuese, Aurélien, Editorial Board Member, Purnhagen, Kai, Editorial Board Member, Reisch, Lucia A., Editorial Board Member, Sibony, Anne-Lise, Editorial Board Member, Stavang, Endre, Editorial Board Member, and Tor, Avishalom, editor

Published
2021
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68. Rue

Author

Gómez, Fernando Herrera and Dupuis, Chanelle

Published
2023

71. Compliance with the clinical guidelines for managing asthma by primary care physicians: An ambispective observational study

Author

Abedianzadeh Timar, Mohsen, Acha Domínguez, Jesús, Aguaviva Bascuñana, Jesus, Aguilar Martín, Ignacio, Ales Conejo, Francisco Ignacio, Alfaro González, Juan Vicente, Alfonso Landa, Patricia, Altés Boronat, Andrés, Álvarez Arriero, Jesús Joaquín, Álvarez Rojo, Juan Ángel, Vidal German, Allut, Amaro Cendón, Jesús, Amiano Arregui, María Teresa, Angulo Vallejo, Esther, Anton Álvarez, Juan José, Anton Ortega, Javier, Arconada Perez, Ana, Ardiaca Burgués, Lidia, Armario Vázquez, Juan Manuel, Arroyo Cubeiro, Amador, Aso Mendialdea, Koldo, Attardo, Francesca, Ávila de Tomás, José Francisco, Avinent Arnal, M. Jesús, Aznar Aguilar, Francisco, Aznar Tejero, Pilar, Baena Montilla, Emilio, Baeza López, José María, Barón Carrillo, Juan José, Bartolomé Resano, Rafael, Becoña de la Torre, Francisco, Benavent Martín, Isabel, Benedí Sánchez, María Teresa, Berrocal del Brío, José, Blanco Delgado, Antonio, Bleda Cano, Jesús, Boladeras Sabater, Josep, Bolívar Mantilla, Zenaida, Brito Brito, Elisenda, Burgos Parra, M. Rosario, Buxadé Martí, Isaac, Caballero Garcia, Juan Carlos, Cabañas Enríquez, Luis Fernando, Calviño Cerqueiro, Marcelino, Calvo Fernández, Juan, Calle Velles, Felipe, Camaro Zafra, Beatriz, Campomar Quetlas, Jaume, Capitán Jurado, Mónica, Cárdenas Joyanes, Dolores, Carles Bueso, Gonzalo, Carvajal Puente, Cristina, Casado Rodriguez, Cristina, Casanova García, Carlos, Castellà Cahiz, Santiago, Castellà Cuesta, Cristina, Castellano Martínez, Manuel Antonio, Catalán Félez, Rafael, Cavada García, Miguel Ángel, Cavada Velasco, Antonio, Cidra Gordillo, Jose Luis, Clemente Garcia, Julia, Collada Jiménez, José Luis, Cornejo Figueroa, Andrés, Cornejo Rodríguez, Roberto, Cuevas Morales, Julio, Curado-Moliní Álvarez, María Jesús, Daviña Romero, Susana, de Arriba Muñoz, Leonor, de la Flor Benítez, Manuel, de la Poza Abad, Mariam, de los Bueis Martinez, Gustavo, de Miguel Márquez, María Pía, de Pablo Martín, Jesús, Delgado Mora, Manuel, Díaz Mateo, Joaquín, Díaz Saborido, Almudena, Díez-Caballero Murua, María, Doganis Peppas, Constantino, Domínguez Alonso, Gonzalo, Domínguez Ávila, Julián, Domínguez González, María Nieves, Domínguez Hernández, María Isabel, Dosantos Hernández, Javier Oscar, Dueñas Buey, Aurelio, Eiris Cambre, M. Jesús, El Wafa Vaca, Yussef Abu, Enseñat Sanchez, Antonio Alberto, Esquerra Tuñí, Eulalia, Esteve Ribelles, José María, Estevez Barrondo, José Antonio, Estraviz Vidal, M. Dolores, Fajardo Salguero, Rosa María, Felipe Olivero, José Francisco, Fernández Bujía, María Luisa, Fernández Cano, Patricia, Fernández Cañaveras, M. Isabel, Fernández Fernández, Carmen, Fernández García, José Manuel, Fernández Gómez, Patricia, Fernández González, José María, Fernández Gutiérrez Denia, Irene, Fernández Huelga, M. Esther, Fernández Martin, Yolanda, Fernández Navarro, Francisco, Fernández Revuelta, Araceli, Fernández Toro, José María, Fernández-Pacheco Corchado, Luis María, Ferrándiz Miquel, Joaquín, Ferrari Piquero, Carmen, Ferrer García-Borrás, José María, Gago Fernandez, Carlos, Gago Gómez, Fernando, Galera de Ulierte, Luz Inmaculada, Gallegos Juárez, Ingrid, Garceran Azorín-Gómez, José Enrique, Garcés Romero, Carmen, García Alonso, Francisco Javier, García Cabana, Andres A., García Cano, Josefa, García Ceballos, Victoria Gema, García de Francisco, Sara, García Fuentes, Francisco, García Vázquez, Yolanda, García Collado, Sergio, García-Giralda Ruiz, Luis, García-Serrano Jiménez, Beatriz, Garrido Pérez, Montse, Garro Mendiolagaray, Jon Kepa, Gea Villar, Jorge, Genover Llimona, Teresa, Gil Moreno, Felipe, Gil Pastor, Javier Julián, Gispert Servitje, Adrià, Godoy García, Isidro Domingo, Gómez Martínez, Gabriel, Gómez Sanmiguel, Francisco Javier, Gómez Yelo, Jose, Gonzales Flores, Pedro Alejandro, González Hernández, Luis, Gonzálvez Rey, Jaime, Gorgues Comas, Roberto, Guillen Anton, María Victoria, Gutiérrez Almarza, Miguel Ángel, Gutiérrez Esteban, Jose Luis, Guzón Centeno, Marta, Hermoso Sabio, Antonio, Hernández Castellanos, Manuel, Hernández Pérez, Ana, Herranz Alfaro, Alfredo, Hinojosa Díaz, José Francisco, Iglesias Fernández, José, Intxausti Erdoiza, Iñaki, Izarra Páramo, Miriam, Jiménez Marcen, Ana Isabel, Jimeno Bernad, Rosa María, Jover Andreu, María José, Juan Alcaraz, Francisco Emilio, Labrador Arranz, Esther, Laencina López, Salvador, Lapuente Troncoso, Elena, Latorre Cásedas, Montserrat, Leal Hernández, Mariano, Ledesma Santiago, Lourdes, Lillo Bravo, Francisco Javier, Lizarribar Sans, Marta, Lobato Martínez, Rocío, López Alonso, Emilia Begoña, López Cruz, Urbano, López Chamon, Silvia, López de Viñaspre Muguerza, Ana Isabel, López Herranz, Ana Belén, López Marina, Víctor, López Ortiz, Francisco, López Silva, Mª Carmen, Lucas Boronat, José María, Lugo Ramos, Héctor Leonardo, Lutz Garcia, Erika, Llosa Ventura, Juan Luis, Macías Corbacho, Antonio, Magem Niubo, Juan, Mancilla las Heras, Diego, Maneu Juan, Alfonso, Manzano Jiménez, José, Mañes Vicente, Pascual, Maranges Comella, María Isabel, Marco Segarra, Emilio, María Tablado, Miguel Ángel, Marlasca Garcia, Juan Carlos, Martí Canales, Juan Carlos, Martín Clos, José, Martín de la Vega, Saúl, Martín Ruiz Lavela, Francisco, Martinez Aparicio, M. Desamparada, Martínez de Carnero Calzada, Rafael, Martinez González, Agustín, Martínez Jiménez, Juan Manuel, Martínez Laguna, Daniel, Martínez Mayora, María Teresa, Martinez Merodio, Pilar, Martínez Novoa, Luis, Martínez Ortega, Mireia, Martínez Rojas, Francisco, Martínez Rossello, Antonio, Meijome Sánchez, María del Carmen, Méndez-Cabeza Velázquez, Jesús, Méndez Maiques, Jose María, Misericordia Garcia, Santiago, Molina Cabildo, José, Molina Martínez, Luis Javier, Monge García, José Manuel, Montes Belloso, María Ester, Moreno Molina, Susana, Motos Díaz, Patrocinio, Mourelo Cereijo, Marta, Moyá Amengual, Ana, Muñoz Ruiz, Pedro José, Narváez Martín, José María, Navarro Luna, Juan Luis, Navarro Tarin, Fernando, Nicolau Grego, Jorge, Niño Azcarate, Cristina, Nova Alvarez, José, Núñez Cordón, Juan Carlos, Olagorta de Prado, Asunción, Oros Espinosa, Vicente, Ortega Pinilla, M. Concepción, Ortega Ruiz, María Paz, Osca Pellicer, David, Otamendi Murillo, Ana, Otero Mata, Manuel, Ouzzine Marín, Myriam, Paja Fano, Eduardo, Palacio Gonzalez, Domingo, Palau Oñate, Rosario, Pazos Garrido, Néstor, Pecharroman Fuente, Virginia, Peña Rosa, Jose Manuel, Peral Cabot, Francisco Javier, Pérez Barreto, Iván Yamir, Pérez Caballero, Isabel, Pérez Fernández, Maria del Carmen, Pérez Fernández, Antonio Luis, Pérez Gutiérrez, Esteban, Pérez Rios, Manuel, Petit Sánchez, José Manuel, Piñero Acin, Maria José, Pozuelos Estrada, Jerónimo, Prieto Cid, Manuel, Prieto Gutiérrez, Joaquín, Raga Casasus, José Vicente, Ramírez Espinosa, Manuel Francisco, Rebollo Hernamperez, Eduardo, Rey Rañal, Alejandra, Ribelles Villalba, Ricardo Sagunto, Rodas Peral, José Antonio, Rodil Martinez, Aurora, Rodríguez, Manuel, José, Rodríguez Calcaño, Enrique Emperador, Rodríguez Fernandez, Concepción, Rodríguez Galipienzo, José Miguel, Rodriguez Lois, Miguel Ángel, Rodríguez Partida, José Antonio, Roel Conde, Jaime, Roman Rodriguez, Miguel, Romero Caballero, Gregorio, Romero Hernández, Pedro, Rosales García, Luis Miguel, Royo del Río, Manuel, Ruiz Gomes, María, Ruiz Moruno, Francisco Javier, Ruiz Perez, Jaime, Salinero Acevedo, José Ramón, Sánchez Apresa, Manuel, Sanchez Calavera, María Antonia, Sánchez Garcia, Fernando, Sánchez Gutiérrez, Miguel Ángel, Sánchez Ibáñez, Antonio, Sánchez López, Eugenio, Sánchez Loureiro, Manuel, Sanchez Lozano, Ana, Sánchez Romero, Gregorio, Sánchez Ruano, Fernando, Sánchez Ruiz, Gabriela, Sánchez Sanchez, Froilán, Santiago Ayarza, Asier, Santos Bermejo, Juan Antonio, Sanz de Miguel, Elena, Sanz Sanz, Marta, Sanz Velasco, Carmelina, Sauco Colón, Inmaculada, Sedano García, José Ignacio, Segovia Castro, Luis, Senan Sanz, María Rosa, Serra Cabot, Pere, Serra Gallego, Marta, Serrano Tomás, Daniel, Sesma Aisa, Francisco Tomás, Seuba Garcés, Jordi, Soler David, Vicente, Soria Mesa, Jose Antonio, Sosa Álvarez, César, Suárez Pérez, María, Tafalla Martín, Antonio, Tamayo Ferriol, Thaimi, Tamayo Marín, José Luis, Thalamas Atienza, Juan Aitor, Toledo Muñoz, Ana María, Tomás-Rodo Massaneda, Lluis Miquel, Torres de Castro, Milko, Torres Martínez, Francisco Javier, Tovar Álvarez, Enrique, Ugarte Goñi, Ainhoa, Valle González, Irene, Vasco Mahillo, Sonia, Enrique José, Vázquez Seijas, Vericat Roure, Antonio, Villalba Parrado, Arelis, Villanueva Rebollo, Jose María, Villar Valgañon, Ricardo, Villena Masegosa, Vicente, Viñals Gigena, Montserrat, Viñas Cabrera, Lydia, Zarco Pinteño, David, Roman-Rodriguez, M., Molina-Paris, J., and Fernandez Sanchez, A.

Published
2021
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74. Seguimiento de las guías españolas para el manejo del asma por el médico de atención primaria: un estudio observacional ambispectivo

Author

Abedianzadeh Timar, Mohsen, Acha Domínguez, Jesús, Aguaviva Bascuñana, Jesus, Aguilar Martín, Ignacio, Ales Conejo, Francisco Ignacio, Alfaro González, Juan Vicente, Alfonso Landa, Patricia, Altés Boronat, Andrés, Álvarez Arriero, Jesús Joaquín, Álvarez Rojo, Juan Ángel, Vidal German, Allut, Amaro Cendón, Jesús, Amiano Arregui, María Teresa, Angulo Vallejo, Esther, Anton Álvarez, Juan José, Anton Ortega, Javier, Arconada Perez, Ana, Ardiaca Burgués, Lidia, Armario Vázquez, Juan Manuel, Arroyo Cubeiro, Amador, Aso Mendialdea, Koldo, Attardo, Francesca, Ávila de Tomás, José Francisco, Avinent Arnal, M. Jesús, Aznar Aguilar, Francisco, Aznar Tejero, Pilar, Baena Montilla, Emilio, Baeza López, José María, Barón Carrillo, Juan José, Bartolomé Resano, Rafael, Becoña de la Torre, Francisco, Benavent Martín, Isabel, Benedí Sánchez, María Teresa, Berrocal del Brío, José, Blanco Delgado, Antonio, Bleda Cano, Jesús, Boladeras Sabater, Josep, Bolívar Mantilla, Zenaida, Brito Brito, Elisenda, Burgos Parra, M. Rosario, Buxadé Martí, Isaac, Caballero Garcia, Juan Carlos, Cabañas Enríquez, Luis Fernando, Calviño Cerqueiro, Marcelino, Calvo Fernández, Juan, Calle Velles, Felipe, Camaro Zafra, Beatriz, Campomar Quetlas, Jaume, Capitán Jurado, Mónica, Cárdenas Joyanes, Dolores, Carles Bueso, Gonzalo, Carvajal Puente, Cristina, Casado Rodriguez, Cristina, Casanova García, Carlos, Castellà Cahiz, Santiago, Castellà Cuesta, Cristina, Castellano Martínez, Manuel Antonio, Catalán Félez, Rafael, Cavada García, Miguel Ángel, Cavada Velasco, Antonio, Cidra Gordillo, Jose Luis, Clemente Garcia, Julia, Collada Jiménez, José Luis, Cornejo Figueroa, Andrés, Cornejo Rodríguez, Roberto, Cuevas Morales, Julio, Curado-Moliní Álvarez, María Jesús, Daviña Romero, Susana, de Arriba Muñoz, Leonor, de la Flor Benítez, Manuel, de la Poza Abad, Mariam, de los Bueis Martinez, Gustavo, de Miguel Márquez, María Pía, de Pablo Martín, Jesús, Delgado Mora, Manuel, Díaz Mateo, Joaquín, Díaz Saborido, Almudena, Díez-Caballero Murua, María, Doganis Peppas, Constantino, Domínguez Alonso, Gonzalo, Domínguez Ávila, Julián, Domínguez González, María Nieves, Domínguez Hernández, María Isabel, Dosantos Hernández, Javier Oscar, Dueñas Buey, Aurelio, Eiris Cambre, M. Jesús, El Wafa Vaca, Yussef Abu, Enseñat Sanchez, Antonio Alberto, Esquerra Tuñí, Eulalia, Esteve Ribelles, José María, Estevez Barrondo, José Antonio, Estraviz Vidal, M. Dolores, Fajardo Salguero, Rosa María, Felipe Olivero, José Francisco, Fernández Bujía, María Luisa, Fernández Cano, Patricia, Fernández Cañaveras, M. Isabel, Fernández Fernández, Carmen, Fernández García, José Manuel, Fernández Gómez, Patricia, Fernández González, José María, Fernández Gutiérrez Denia, Irene, Fernández Huelga, M. Esther, Fernández Martin, Yolanda, Fernández Navarro, Francisco, Fernández Revuelta, Araceli, Fernández Toro, José María, Fernández-Pacheco Corchado, Luis María, Ferrándiz Miquel, Joaquín, Ferrari Piquero, Carmen, Ferrer García-Borrás, José María, Gago Fernandez, Carlos, Gago Gómez, Fernando, Galera de Ulierte, Luz Inmaculada, Gallegos Juárez, Ingrid, Garceran Azorín-Gómez, José Enrique, Garcés Romero, Carmen, García Alonso, Francisco Javier, García Cabana, Andres A., García Cano, Josefa, García Ceballos, Victoria Gema, García de Francisco, Sara, García Fuentes, Francisco, García Vázquez, Yolanda, García Collado, Sergio, García-Giralda Ruiz, Luis, García-Serrano Jiménez, Beatriz, Garrido Pérez, Montse, Garro Mendiolagaray, Jon Kepa, Gea Villar, Jorge, Genover Llimona, Teresa, Gil Moreno, Felipe, Gil Pastor, Javier Julián, Gispert Servitje, Adrià, Godoy García, Isidro Domingo, Gómez Martínez, Gabriel, Gómez Sanmiguel, Francisco Javier, Gómez Yelo, Jose, Gonzales Flores, Pedro Alejandro, González Hernández, Luis, Gonzálvez Rey, Jaime, Gorgues Comas, Roberto, Guillen Anton, María Victoria, Gutiérrez Almarza, Miguel Ángel, Gutiérrez Esteban, Jose Luis, Guzón Centeno, Marta, Hermoso Sabio, Antonio, Hernández Castellanos, Manuel, Hernández Pérez, Ana, Herranz Alfaro, Alfredo, Hinojosa Díaz, José Francisco, Iglesias Fernández, José, Intxausti Erdoiza, Iñaki, Izarra Páramo, Miriam, Jiménez Marcen, Ana Isabel, Jimeno Bernad, Rosa María, Jover Andreu, María José, Juan Alcaraz, Francisco Emilio, Labrador Arranz, Esther, Laencina López, Salvador, Lapuente Troncoso, Elena, Latorre Cásedas, Montserrat, Leal Hernández, Mariano, Ledesma Santiago, Lourdes, Lillo Bravo, Francisco Javier, Lizarribar Sans, Marta, Lobato Martínez, Rocío, López Alonso, Emilia Begoña, López Cruz, Urbano, López Chamon, Silvia, López de Viñaspre Muguerza, Ana Isabel, López Herranz, Ana Belén, López Marina, Víctor, López Ortiz, Francisco, López Silva, M.a Carmen, Lucas Boronat, José María, Lugo Ramos, Héctor Leonardo, Lutz Garcia, Erika, Llosa Ventura, Juan Luis, Macías Corbacho, Antonio, Magem Niubo, Juan, Mancilla las Heras, Diego, Maneu Juan, Alfonso, Manzano Jiménez, José, Mañes Vicente, Pascual, Maranges Comella, María Isabel, Marco Segarra, Emilio, María Tablado, Miguel Ángel, Marlasca Garcia, Juan Carlos, Martí Canales, Juan Carlos, Martín Clos, José, Martín de la Vega, Saúl, Martín Ruiz Lavela, Francisco, Martinez Aparicio, M. Desamparada, Martínez de Carnero Calzada, Rafael, Martinez González, Agustín, Martínez Jiménez, Juan Manuel, Martínez Laguna, Daniel, Martínez Mayora, María Teresa, Martinez Merodio, Pilar, Martínez Novoa, Luis, Martínez Ortega, Mireia, Martínez Rojas, Francisco, Martínez Rossello, Antonio, Meijome Sánchez, María del Carmen, Méndez-Cabeza Velázquez, Jesús, Méndez Maiques, Jose María, Misericordia Garcia, Santiago, Molina Cabildo, José, Molina Martínez, Luis Javier, Monge García, José Manuel, Montes Belloso, María Ester, Moreno Molina, Susana, Motos Díaz, Patrocinio, Mourelo Cereijo, Marta, Moyá Amengual, Ana, Muñoz Ruiz, Pedro José, Narváez Martín, José María, Navarro Luna, Juan Luis, Navarro Tarin, Fernando, Nicolau Grego, Jorge, Niño Azcarate, Cristina, Nova Alvarez, José, Núñez Cordón, Juan Carlos, Olagorta de Prado, Asunción, Oros Espinosa, Vicente, Ortega Pinilla, M. Concepción, Ortega Ruiz, María Paz, Osca Pellicer, David, Otamendi Murillo, Ana, Otero Mata, Manuel, Ouzzine Marín, Myriam, Paja Fano, Eduardo, Palacio Gonzalez, Domingo, Palau Oñate, Rosario, Pazos Garrido, Néstor, Pecharroman Fuente, Virginia, Peña Rosa, Jose Manuel, Peral Cabot, Francisco Javier, Pérez Barreto, Iván Yamir, Pérez Caballero, Isabel, Pérez Fernández, Maria del Carmen, Pérez Fernández, Antonio Luis, Pérez Gutiérrez, Esteban, Pérez Rios, Manuel, Petit Sánchez, José Manuel, Piñero Acin, Maria José, Pozuelos Estrada, Jerónimo, Prieto Cid, Manuel, Prieto Gutiérrez, Joaquín, Raga Casasus, José Vicente, Ramírez Espinosa, Manuel Francisco, Rebollo Hernamperez, Eduardo, Rey Rañal, Alejandra, Ribelles Villalba, Ricardo Sagunto, Rodas Peral, José Antonio, Rodil Martinez, Aurora, Rodríguez, Manuel, José, Rodríguez Calcaño, Enrique Emperador, Rodríguez Fernandez, Concepción, Rodríguez Galipienzo, José Miguel, Rodriguez Lois, Miguel Ángel, Rodríguez Partida, José Antonio, Roel Conde, Jaime, Roman Rodriguez, Miguel, Romero Caballero, Gregorio, Romero Hernández, Pedro, Rosales García, Luis Miguel, Royo del Río, Manuel, Ruiz Gomes, María, Ruiz Moruno, Francisco Javier, Ruiz Perez, Jaime, Salinero Acevedo, José Ramón, Sánchez Apresa, Manuel, Sanchez Calavera, María Antonia, Sánchez Garcia, Fernando, Sánchez Gutiérrez, Miguel Ángel, Sánchez Ibáñez, Antonio, Sánchez López, Eugenio, Sánchez Loureiro, Manuel, Sanchez Lozano, Ana, Sánchez Romero, Gregorio, Sánchez Ruano, Fernando, Sánchez Ruiz, Gabriela, Sánchez Sanchez, Froilán, Santiago Ayarza, Asier, Santos Bermejo, Juan Antonio, Sanz de Miguel, Elena, Sanz Sanz, Marta, Sanz Velasco, Carmelina, Sauco Colón, Inmaculada, Sedano García, José Ignacio, Segovia Castro, Luis, Senan Sanz, María Rosa, Serra Cabot, Pere, Serra Gallego, Marta, Serrano Tomás, Daniel, Sesma Aisa, Francisco Tomás, Seuba Garcés, Jordi, Soler David, Vicente, Soria Mesa, Jose Antonio, Sosa Álvarez, César, Suárez Pérez, María, Tafalla Martín, Antonio, Tamayo Ferriol, Thaimi, Tamayo Marín, José Luis, Thalamas Atienza, Juan Aitor, Toledo Muñoz, Ana María, Tomás-Rodo Massaneda, Lluis Miquel, Torres de Castro, Milko, Torres Martínez, Francisco Javier, Tovar Álvarez, Enrique, Ugarte Goñi, Ainhoa, Valle González, Irene, Vasco Mahillo, Sonia, Enrique José, Vázquez Seijas, Vericat Roure, Antonio, Villalba Parrado, Arelis, Villanueva Rebollo, Jose María, Villar Valgañon, Ricardo, Villena Masegosa, Vicente, Viñals Gigena, Montserrat, Viñas Cabrera, Lydia, Zarco Pinteño, David, Roman-Rodriguez, M., Molina-Paris, J., and Fernandez-Sanchez, A.

Published
2021
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75. Static solutions in Einstein-Chern-Simons gravity

Author

Crisóstomo, Juan, Gomez, Fernando, Mella, Patricio, Quinzacara, Cristian, and Salgado, Patricio

Subjects
General Relativity and Quantum Cosmology, High Energy Physics - Theory
Abstract

In this paper we study static solutions with more general symmetries than the spherical symmetry of the five-dimensional Einstein-Chern-Simons gravity. In this context, we study the coupling of the extra bosonic field $% h^{a}$ with ordinary matter which is quantified by the introduction of an energy-momentum tensor field associated with $h^{a}$. It is found that exist (i) a negative tangential pressure zone around low-mass distributions ($\mu <\mu_{1}$) when the coupling constant $\alpha $ is greater than zero; (ii) a maximum in the tangential pressure, which can be observed in the outer region of a field distribution that satisfies $\mu <\mu_{2}$; (iii) solutions that behave like those obtained from models with negative cosmological constant. In such a situation, the field $h^{a}$ plays the role of a cosmological constant., Comment: 23 pages, 6 figures

Published
2016
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80. The identity of Centrodinium elongatum, type species of the dinoflagellate genus Centrodinium (Dinophyceae), and a review on the synonymy of allied species.

Author

Gómez, Fernando, Navarrete‐Carlos, Tania Corina, López‐Osorio, Yahir Enrique, Zhang, Huan, Raymond, Eugenio, Salas, Rafael, Alonso‐Rodríguez, Rosalba, and Lin, Senjie

Subjects
*ECDYSIS, *ALEXANDRIUM, *DINOFLAGELLATES, *PHYLOGENY, *RECOMBINANT DNA
Abstract

The planktonic dinoflagellate genus Centrodinium has been understudied, with the type species C. elongatum remaining undocumented since the original description. Here, we report C. elongatum isolated from Mazatlán, Mexican Pacific. In the chains, the posterior daughter cell with an incomplete apical horn shows the morphology of C. elongatum, while the anterior daughter cell with complete epitheca corresponds to C. pulchrum. For the first time, a species of Centrodinium sensu stricto (highly laterally flattened species with horns) was cultured. An unarmored life stage, known as Murrayella ovalis, derived from the spheroplast after ecdysis. In the rDNA molecular phylogenies, C. elongatum (=C. pulchrum) nested as basal to morphologically similar species (C. eminens and C. intermedium) and as a sister group of a former Murrayella species, C. punctatum. C. elongatum differs from C. eminens and C. intermedium in the chain formation, second apical (2′) plate not being divided, horns with coarse poroid ornamentation, and missing prominent distal spinules. The taxonomy of Centrodinium sensu stricto is revised, with a discussion in the identities of C. complanatum, C. eminens, and C. maximum. The name C. deflexum is restored as a senior synonym of C. intermedium and C. ovale. [ABSTRACT FROM AUTHOR]

Published
2024
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81. Maternal dietary antioxidant supplementation regulates weaned piglets' adipose tissue transcriptome and morphology.

Author

Laviano, Hernán D., Gómez, Gerardo, Núñez, Yolanda, García-Casco, Juan M., Benítez, Rita M., de las Heras-Molina, Ana, Gómez, Fernando, Sánchez-Esquiliche, Fernando, Martínez-Fernández, Beatriz, González-Bulnes, Antonio, Rey, Ana I., López-Bote, Clemente J., Muñoz, María, and Óvilo, Cristina

Subjects
FAT cells, ADIPOSE tissues, CELL physiology, HOMEOSTASIS, DIETARY supplements, VITAMIN E, ANIMAL weaning, PIGLETS
Abstract

Antioxidant supplementation in critical periods may be useful for improvement of piglet early viability and development. We have evaluated the effects of maternal perinatal diet inclusion of a high vitamin E level (VE, 100 mg all-rac-α-tocopheryl acetate /kg), hydroxytyrosol (HT, 1.5 mg/kg), or their combination (VEHT), in comparison to a control diet (C, 30 mg all-rac-α-tocopheryl acetate /kg), on the offspring homeostasis and metabolism, analysing the weaned piglets' adipose tissue transcriptome and adipocyte morphology. Diets were provided to pregnant Iberian sows (n = 48, 12 per treatment) from gestation day 85 to weaning (28 days postpartum) and 48 piglets (n = 12 per treatment) were sampled 5 days postweaning for dorsal subcutaneous adipose tissue analyses. RNA obtained from 6 animals for each diet was used for paired-end RNA sequencing. Results show that supplementation of sows' diet with either vitamin E or hydroxytyrosol had substantial effects on weaned piglet adipose transcriptome, with 664 and 587 genes being differentially expressed, in comparison to C, respectively (q-value<0.10, Fold Change>1.5). Genes upregulated in C were mainly involved in inflammatory and immune response, as well as oxidative stress, and relevant canonical pathways and upstream regulators involved in these processes were predicted as activated, such as TNF, IFNB or NFKB. Vitamin E, when supplemented alone at high dose, activated lipid biosynthesis functions, pathways and regulators, this finding being accompanied by increased adipocyte size. Results suggest an improved metabolic and antioxidant status of adipose tissue in animals born from sows supplemented with individual antioxidants, while the combined supplementation barely affected gene expression, with VEHT showing a prooxidant/proinflamatory functional profile similar to C animals. Different hypothesis are proposed to explain this unexpected result. Findings allow a deeper understanding of the processes taking place in adipose tissue of genetically fat animals and the role of antioxidants in the regulation of fat cells function. [ABSTRACT FROM AUTHOR]

Published
2024
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84. Long-Term Effect of Maternal Antioxidant Supplementation on the Lipid Profile of the Progeny According to the Sow’s Parity Number

Author

Gómez, Gerardo, primary, Laviano, Hernan D., additional, García-Casco, Juan, additional, Muñoz, Maria, additional, Gómez, Fernando, additional, Sánchez-Esquiliche, Fernando, additional, González-Bulnes, Antonio, additional, López-Bote, Clemente, additional, Óvilo, Cristina, additional, and Rey, Ana I., additional

Published
2024
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88. Sobreviviendo a la SEPSIS

Author

Humanante Avilés, Carlos Humberto, primary, Suarez Loor, Wilfrido Alejandro, additional, Choez Quimis, Ariana Tatiana, additional, León Vergara, Danixa Lourdes, additional, Lange González, Iván Fabricio, additional, Carranza Gómez, Fernando Jacinto, additional, Guerrero Farias, Diego Gustavo, additional, Guerra Rosado, Martha Llamileh, additional, Hidalgo Bermúdez, Carlos Andrés, additional, Cali Muñoz, onathan Michael, additional, and Arcos González, Manuel Ildauro, additional

Published
2021
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89. Scale Modular Test Platform for the Characterization of PD Measuring Systems Using HFCT Sensors

Author

Arcones del Álamo, Eduardo, Álvarez Gómez, Fernando, Khamlichi El Khamlichi, Abderrahim, Garnacho Vecino, Fernando, Arcones del Álamo, Eduardo, Álvarez Gómez, Fernando, Khamlichi El Khamlichi, Abderrahim, and Garnacho Vecino, Fernando

Abstract

Today, online partial discharge (PD) measurements are common practice to assess the condition status of dielectrics in high-voltage (HV) electrical grids. However, when online PD measurements are carried out in electrical facilities, several disadvantages must be considered. Among the most important are high levels of changing electrical noise and interferences, signal phase couplings (cross-talk phenomena), and the simultaneous presence of various defects and difficulties in localizing and identifying them. In the last few decades, various PD-measuring systems have been developed to deal with these inconveniences and try to achieve the adequate supervision of electrical installations. In the state of the art, one of the main problems that electrical companies and technology developers face is the difficulty in characterizing the measuring system’s functionalities in laboratory setups or in real-world facilities, where simulated or real defects must be detected. This is mainly due to the complexity and costs that the laboratory setups entail and the fact that the facilities are permanently in service. Furthermore, in the latter scenario, owners cannot assign facilities to carry out the tests, which could cause irreversible damage. Additionally, with the aforementioned installations, a comparison of results over time in various locations is not possible, and noise conditions cannot be controlled to perform the characterizations in a correct way. To deal with the problems indicated, in this article, an affordable scale modular test platform that simulates an HV installation is presented, where real on-site PD measuring conditions are simulated and controlled. In this first development, the HV installation comprises a cable system connected at both ends to a gas-insulated substation (GIS). As the most common acquisition technique in online applications is based on the placement of high-frequency current transformer (HFCT) sensors in the grounding cables of facilities

Published
2024

90. Gods and men: omens, legitimacy, and power in Imperial Rome

Author

Lozano Gómez, Fernando, Santa Bárbara, María Leonor, Universidad de Sevilla. Departamento de Historia Antigua, Castro Campos, Rubén Henrique de, Lozano Gómez, Fernando, Santa Bárbara, María Leonor, Universidad de Sevilla. Departamento de Historia Antigua, and Castro Campos, Rubén Henrique de

Abstract

Dozens of Roman authors included omens in their narratives, telling of a world of gods and men, of signs of the future and prodigious events. The mythical narrative that rises from those portents is tell-tale of the belief that gods sent signs of what the future held for Rome and its leaders. That collectively imagined world is the focus of this thesis, which attempts to study it through the analysis of imperial omens from the rise of Nerva to the death of Severus Alexander (framing them in a wider reality of Roman divination and its religious construction of power and its narratives). This thesis focuses on imperial omens as a phenomenon by itself and as a tool for studying the cosmovision and mythology of power in Ancient Rome. The priority is understanding which conception of imperial power (its explaining myths and imagined origins and limits) and which relationship between gods and community (and gods and emperors, the heads of the human community) is expressed in Roman imperial omens form Nerva to Severus Alexander (98-235 A.D.). From the detailed analysis of imperial omens and of the society and mental cosmos in which they made sense, this thesis reconstructed imperial power as it is expressed in imperial portents. In a world where political power was constructed and imagined in religious terms, that analysis revealed itself to be quite fruitful. Several elements were analysed throughout the thesis: the fundamental function of imperial omens; the ideological consuetudinary continuum in which they partook; their likely origin; their social and geographical audience; what gods are imagined participating in the narrative of power offered by the prodigies; how is the emperor conveyed; and which problems are posed by the Historia Augusta’s omens. By understanding religion as a mechanism linking the world as lived and the world as imagined, omens are concluded to be a sense-ascribing coping mechanism, a bridging tool of sorts explaining the chaos of human existence

Published
2024

91. Estudio de diferentes alternativas para satisfacer las necesidades térmicas del antiguo Hotel Peninsular de Cartagena para su uso como edificio administrativo

Author

Illán Gómez, Fernando, Ingeniería Térmica y de Fluidos, Cánovas Cabrera, Ana, Illán Gómez, Fernando, Ingeniería Térmica y de Fluidos, and Cánovas Cabrera, Ana

Abstract

Actualmente, los edificios y el sector de construcción de edificios combinados son responsables de aproximadamente un tercio del consumo total de energía final mundial, siendo uno de los mayores consumidores en la Unión Europea (UE). Asimismo, se encuentran entre los principales emisores de dióxido de carbono (CO2). Concretamente, los edificios son responsables del 40 % del consumo energético de la UE y del 36 % de las emisiones de gases de efecto invernadero, generalmente producidas durante los procesos de construcción, utilización, renovación y demolición [1]. Por estos motivos, el progreso en el ámbito de la eficiencia energética en los edificios es decisivo para lograr el objetivo fijado en el Pacto Verde Europeo de alcanzar la neutralidad en emisiones de carbono para 2050. Además, de ser un aspecto a tener en cuenta para poder afrontar el continuo aumento de la demanda de energía de este sector. Dicho aumento se debe a la existencia de un mejor acceso a la energía en los países en desarrollo, la demanda progresiva de aire acondicionado en los países tropicales, una mayor propiedad y empleo de electrodomésticos que consumen energía y un incremento de la superficie total de los edificios [2]. Por ello, en la actualidad, se están introduciendo nuevas medidas con el fin de impulsar una mayor eficiencia energética de los edificios y de esta manera, contribuir a la consecución de los diferentes objetivos energéticos y climáticos determinados. Desde la UE se está invirtiendo en subvenciones o préstamos para ayudar a fomentar la tecnología y las mejores prácticas en dicho sector. Por ejemplo, el uso de contadores inteligentes, materiales que presentan un mayor rendimiento y diferentes herramientas digitales facilitan que haya un control más preciso del consumo de energía por parte de los consumidores, y, por consiguiente, un ahorro de energía [1]. Este trabajo fin de máster se enmarca dentro de la línea de investigación “Energías Renovables y Eficiencia Energética asoc

Published
2024

92. TripMerge: Aplicación web para planificar viajes entre distintas personas

Author

Velasco Plaza, Rubén, Díaz Gómez, Fernando, Universidad de Valladolid. Escuela de Ingeniería Informática de Segovia, Velasco Plaza, Rubén, Díaz Gómez, Fernando, and Universidad de Valladolid. Escuela de Ingeniería Informática de Segovia

Abstract

El objetivo principal de este Trabajo Final de Grado es el ofrecer la facilidad para gestionar un viaje individual o con varias personas. De esta forma, se crea TripMerge, una aplicación web que contiene varios apartados para almacenar equipaje, gastos y actividades que conlleva un viaje. Todo ello es compartido entre distintos usuarios para unificar el viaje y sea más accesible para las personas. La aplicación web se ha desarrollado con Node.JS, el framework Vue y gestor de base de datos MySQL. La implementación de pila completa (tanto la parte del front-end como del back-end) es una muy buena puesta en práctica de los conocimientos adquiridos en el grado., Grado en Ingeniería Informática de Servicios y Aplicaciones

Published
2024

93. DocCraft: Crea Documentos PDF con Simplicidad

Author

Gómez Gómez, Fernando, Grande González, Pilar, Universidad de Valladolid. Escuela de Ingeniería Informática de Segovia, Gómez Gómez, Fernando, Grande González, Pilar, and Universidad de Valladolid. Escuela de Ingeniería Informática de Segovia

Abstract

DocCraft es una aplicación web que permite crear currículum vitae profesional en formato pdf de manera fácil, sencilla y cómoda. La aplicación mostrará al usuario las distintas secciones de información a considerar, permitiéndole introducir/actualizar/borrar los datos correspondientes a cada una de ellas. Finalmente, el usuario podrá seleccionar una plantilla y generar el documento., Departamento de Informática, Grado en Ingeniería Informática de Servicios y Aplicaciones

Published
2024

94. Aplicación web de puntos de interés geolocalizados

Author

González Herrero, Eva María, Díaz Gómez, Fernando, Universidad de Valladolid. Escuela de Ingeniería Informática de Segovia, González Herrero, Eva María, Díaz Gómez, Fernando, and Universidad de Valladolid. Escuela de Ingeniería Informática de Segovia

Abstract

Dado que en la vida moderna la mayoría de los trabajos requieren de estar sentado en una oficina, hacen muy difícil disfrutar del aire libre y de lugares de ocio fuera de nuestro ambiente doméstico. Con esta aplicación, se busca fomentar que las personas incorporen a su vida nuevas formas de disfrutar de diversas experiencias recreativas, ya sea jugar en un billar, tomar una cerveza en un bar, visitar un museo o explorar nuevos paisajes. El objetivo es crear una aplicación web que permita gestionar puntos de interés, tanto urbanos como rurales, y que ofrezca a los usuarios la posibilidad de marcar sus lugares favoritos. Los usuarios podrán subir fotos de los lugares visitados y añadir una descripción, creando así una comunidad de recomendaciones y experiencias compartidas., Grado en Ingeniería Informática de Servicios y Aplicaciones

Published
2024

95. Desarrollo de un modelo de IA para la detección y el reconocimiento de señales de tráfico en imágenes

Author

Bobillo Rincón, Gonzalo, Díaz Gómez, Fernando, Pagano, Vincenzo, Bobillo Rincón, Gonzalo, Díaz Gómez, Fernando, and Pagano, Vincenzo

Abstract

Recientemente, los avances en inteligencia artificial y visión por computador han impulsado el desarrollo de tecnologías innovadoras en varios sectores, entre ellos, la industria automotriz. Los vehículos autónomos y ADAS han aprovechado estas técnicas para interpretar el entorno con mayor precisión y rapidez. Una de las áreas clave para la seguridad en carretera y la efectividad de estos sistemas es la identificación de señales de tráfico, esenciales en la toma de decisiones en la conducción. Este trabajo se enfoca en la creación de un modelo de deep learning, específicamente YOLOv7, para la detección y clasificación de señales de tráfico en imágenes. El desarrollo del proyecto incluye la recopilación y el preprocesamiento de conjuntos de datos públicos, la implementación, entrenamiento y evaluación del modelo y el análisis de varios hiperparámetros críticos. Los resultados sugieren un gran potencial para mejorar la seguridad y fiabilidad de los sistemas autónomos, proponiendo futuras investigaciones para aumentar la precisión y adaptabilidad del modelo a entornos más complejos, impulsando aún más la integración de la IA en la industria automotriz., Departamento de Informática, Grado en Ingeniería Informática de Servicios y Aplicaciones

Published
2024

96. Long-Term Effect of Maternal Antioxidant Supplementation on the Lipid Profile of the Progeny According to the Sow’s Parity Number

Author

Gómez, Gerardo, Laviano, Hernan D., García-Casco, Juan, Muñoz, Maria, Gómez, Fernando, Sánchez-Esquiliche, Fernando, González-Bulnes, Antonio, López-Bote, Clemente, Óvilo, Cristina, Rey, Ana I., Gómez, Gerardo, Laviano, Hernan D., García-Casco, Juan, Muñoz, Maria, Gómez, Fernando, Sánchez-Esquiliche, Fernando, González-Bulnes, Antonio, López-Bote, Clemente, Óvilo, Cristina, and Rey, Ana I.

Abstract

Pig feeding prior to the extensive fattening phase might affect the final lipid profile and product quality. This study evaluates how maternal supplementation with vitamin E (VITE) (100 mg/kg), hydroxytyrosol (HXT) (1.5 mg/kg), or combined administration (VE + HXT) affects the piglet’s plasma and tissues’ fatty acid profiles and lipid stability according to the sow’s parity number (PN), as well as the possible changes to the lipid profile after extensive feeding. The sows’ PN affected the total fatty acid profile of plasma, muscle, and liver of piglets, with lower Δ-9 and Δ-6 desaturase indices but higher Δ-5 in those from primiparous (P) than multiparous (M) sows. Dietary VITE was more effective at decreasing C16:0 and saturated fatty acids in the muscle of piglets born from M than P sows, and modified the liver phospholipids in a different way. Sows’ supplementation with HXT increased C18:2n-6 in triglycerides and polyunsaturated fatty acids (PUFA) in muscle phospholipids. In the liver, HXT supplementation also increased free-PUFA and free-n-3 fatty acids. However, lipid oxidation of piglets’ tissues was not affected by the antioxidant supplementation, and it was higher in the livers of piglets born from M sows. The fatty acid profile in the muscle of pigs after extensive feeding was not affected by the PN, but it was by the sows’ antioxidant supplementation, with positive effects on quality by both compounds.

Published
2024

97. Ciencia vs Opinión 1. Ganadería y cambio climático

Author

Giráldez, Francisco Javier [0000-0002-0680-1541], Bodas Rodríguez, Raúl [0000-0001-9736-7041], Andrés, Sonia [0000-0001-5255-1582], Martín González, Alba [0000-0002-2531-5047], Giráldez, Francisco Javier, Andrés, Sonia, Rozada Gómez, Fernando, Martín, Alba, Giráldez, Francisco Javier [0000-0002-0680-1541], Bodas Rodríguez, Raúl [0000-0001-9736-7041], Andrés, Sonia [0000-0001-5255-1582], Martín González, Alba [0000-0002-2531-5047], Giráldez, Francisco Javier, Andrés, Sonia, Rozada Gómez, Fernando, and Martín, Alba

Published
2024

98. Cochlear microphonic audiometry: a new hearing test for objective diagnosis of deafness

Author

Poch Broto, Joaquín, Carricondo Orejana, Francisco Javier, Bhathal, Beatriz, Iglesias Moreno, María Cruz, López-Moya, Julio, Rodríguez Gómez, Fernando Luis, Sanjuán, Julio, Gil Loyzaga, Pablo, Poch Broto, Joaquín, Carricondo Orejana, Francisco Javier, Bhathal, Beatriz, Iglesias Moreno, María Cruz, López-Moya, Julio, Rodríguez Gómez, Fernando Luis, Sanjuán, Julio, and Gil Loyzaga, Pablo

Abstract

Conclusions: Objective audiometric tests could constitute a valuable tool for detection of deafness. This could be especially useful in children (universal newborn hearing screening) and non-collaborative patients, who are especially difficult candidates for classic audiometry. The cochlear microphonic audiometry (CMA) technique offers the possibility of obtaining objective audiometric profiles, highly correlated with those obtained by pure tone audiometry (PTA). Therefore, CMA could be used as an alternative test to obtain the audiometric profile of these patients. Objective: The main purpose of the present study was to demonstrate that CMA provides objective audiometric profiles by avoiding active participation by the patient. Subjects and methods. CMA specific equipment, improved for non-invasive recording of cochlear microphonic potentials, was used. This tool plots the recordings obtained as the classic audiogram. Verification of the method was carried out in adult patients by comparing the PTA with the CMA audiometric profiles obtained for each patient. Results: Our findings showed that audiometric profiles obtained from CMA are highly correlated, without statistical differences, to those obtained with PTA. More than 81% of patients explored (91.67% at 250 Hz) exhibited differences below 10 dB(HL) between tests at all exploration frequencies, while a low number of cases showed differences over 20 dB(HL)., Depto. de Inmunología, Oftalmología y ORL, Fac. de Medicina, TRUE, pub

Published
2024

99. Cellular and molecular bases of neuroplasticity: brainstem effects after cochlear damage

Author

Gil Loyzaga, Pablo, Carricondo Orejana, Francisco Javier, Bartolomé Pascual, María Visitación, Iglesias Moreno, María Cruz, Rodríguez Gómez, Fernando Luis, Poch Broto, Joaquín, Gil Loyzaga, Pablo, Carricondo Orejana, Francisco Javier, Bartolomé Pascual, María Visitación, Iglesias Moreno, María Cruz, Rodríguez Gómez, Fernando Luis, and Poch Broto, Joaquín

Abstract

After a cochlear lesion or auditory nerve damage, afferent connections from auditory ganglia can be highly altered. This results in a clear reduction of auditory input and an alteration of connectivity of terminals on cochlear nuclei neurons. Such a process could stimulate the reorganization of the neural circuits and neuroplasticity. Cochlea removal has been demonstrated to be a good model in which to analyse brainstem neuroplasticity, particularly with regard to the cochlear nuclei. After cochlea removal three main periods of degeneration and regeneration were observed. Early effects, during the first week post lesion, involved acute degeneration with nerve ending oedema and degeneration. During the second and, probably, the third post lesion weeks, degeneration was still present, even though a limited and diffuse expression of GAP-43 started. Around 1 month post lesion, degeneration at the cochlear nuclei progressively disappeared and a relevant GAP-43 expression was found. We conclude that neuroplasticity leads neurons to modify their activity and/or their synaptic tree as a consequence of animal adaptation to learning and memory. For the human being neuroplasticity is involved in language learning and comprehension, particularly the acquisition of a second language. Neuroplasticity is important for therapeutic strategies, such as hearing aids and cochlear implants., Universidad Complutense de Madrid, Depto. de Inmunología, Oftalmología y ORL, Fac. de Medicina, TRUE, pub

Published
2024

100. In vitro long-term development of cultured inner ear stem cells of newborn rat

Author

Carricondo Orejana, Francisco Javier, Iglesias Moreno, María Cruz, Rodríguez Gómez, Fernando Luis, Poch Broto, Joaquín, Gil Loyzaga, Pablo, Carricondo Orejana, Francisco Javier, Iglesias Moreno, María Cruz, Rodríguez Gómez, Fernando Luis, Poch Broto, Joaquín, and Gil Loyzaga, Pablo

Abstract

The adult mammalian auditory receptor lacks any ability to repair and/or regenerate after injury. However, the late developing cochlea still contains some stem-cell-like elements that might be used to regenerate damaged neurons and/or cells of the organ of Corti. Before their use in any application, stem cell numbers need to be amplified because they are usually rare in late developing and adult tissues. The numerous re-explant cultures required for the progressive amplification process can result in a spontaneous differentiation process. This aspect has been implicated in the tumorigenicity of stem cells when transplanted into a tissue. The aim of this study has been to determine whether cochlear stem cells can proliferate and differentiate spontaneously in long-term cultures without the addition of any factor that might influence these processes. Cochlear stem cells, which express nestin protein, were cultured in monolayers and fed with DMEM containing 5% FBS. They quickly organized themselves into typical spheres exhibiting a high proliferation rate, self-renewal property, and differentiation ability. Secondary cultures of these stem cell spheres spontaneously differentiated into neuroectodermal-like cells. The expression of nestin, glial-fibrillary-acidic protein, vimentin, and neurofilaments was evaluated to identify early differentiation. Nestin expression appeared in primary and secondary cultures. Other markers were also identified in differentiating cells. Further research might demonstrate the spontaneous differentiation of cochlear stem cells and their teratogenic probability when they are used for transplantation., Depto. de Inmunología, Oftalmología y ORL, Fac. de Medicina, TRUE, pub

Published
2024

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